CN113842350A - Composite anti-dandruff shampoo and preparation method thereof - Google Patents
Composite anti-dandruff shampoo and preparation method thereof Download PDFInfo
- Publication number
- CN113842350A CN113842350A CN202111373198.4A CN202111373198A CN113842350A CN 113842350 A CN113842350 A CN 113842350A CN 202111373198 A CN202111373198 A CN 202111373198A CN 113842350 A CN113842350 A CN 113842350A
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- China
- Prior art keywords
- mixture
- dandruff
- dandruff shampoo
- compound anti
- shampoo according
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Classifications
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Abstract
The invention relates to the technical field of daily chemical products, and aims to provide a compound anti-dandruff shampoo and a preparation method thereof. The method has simple and convenient process, the anti-dandruff composition can be simply compounded into a shampoo formula, and the anti-dandruff composition has no stimulation and mildness to human skin and has obvious anti-dandruff and itching-relieving effects.
Description
Technical Field
The invention relates to the technical field of daily chemicals, in particular to a compound anti-dandruff shampoo and a preparation method thereof.
Background
Most of the shampoo on the market contains more or less antidandruff agents such as zinc pyrithione, piroctone olamine, ketoconazole and the like.
Zinc pyrithione can cause toxicity to embryos, and should be used with caution for pregnant women. According to the regulations in the 'cosmetic hygienic standards' of China, the maximum allowable concentration of zinc pyrithione is 1.5%, and actually, the concentration of zinc pyrithione reaches 2% or more in order to achieve the ideal effect of removing dandruff in certain brands.
Compared with zinc pyrithione, piroctone olamine has low toxicity and good stability, but is a component which is not easily dissolved in water and easily remains on the scalp.
Unlike zinc pyrithione and piroctone olamine, ketoconazole is not a cosmetic raw material in fact, but an antifungal drug. Ketoconazole has been called out of the over-the-counter list because of its side effects such as hepatotoxicity.
After long-term use of the shampoo, not only irreversible damage to the scalp due to chemical residues is caused, but also the anti-dandruff components are absorbed into blood microcirculation through the scalp, and the body is adversely affected.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide the composite anti-dandruff shampoo which utilizes the antibacterial characteristics of plant extracts and the traditional anti-dandruff agent to carry out combined compounding, can improve the self-repairing capability of the scalp, normalizes the aging cutin shedding of the scalp, has good anti-dandruff effect, can effectively remove the grease secreted by the hair and the scalp, and reduces the head itching.
The invention also aims to provide a preparation method of the compound anti-dandruff shampoo.
In order to achieve the purpose, the invention adopts the following technical scheme:
the compound anti-dandruff shampoo comprises the following components in percentage by mass:
optionally, the humectant is one or more of allantoin, sodium PCA, panthenol and ethylhexyl glycerin.
Optionally, the foam booster is one or a mixture of more of acrylic acid/VA copolymer, cocamidopropyl hydroxysultaine, propylene glycol laurate and PEG-120 distearate.
Optionally, the surfactant is one or more of ammonium coco polyether sulfate, ammonium lauryl sulfate, sodium cocoamphoacetate and cocamide MEA.
Optionally, the anti-dandruff agent is one or more selected from cortex Magnolia officinalis extract, folium Nelumbinis extract, cortex Salicis Babylonicae extract, piroctone olamine, climbazole, hydroxyphenylpropionamidobenzoic acid, alanylglutamine, and hexamidine dihydrochloride.
Optionally, the cortex magnoliae officinalis bark extract is prepared from the following raw materials in percentage by mass: the lotus leaf extract comprises the following components: the white willow bark extract is 1:1: 1.
Optionally, the thickener is one or a mixture of more of PEG-150 distearate, xanthan gum, guar gum and seaweed gel; the emulsifier is one or more of cetearyl alcohol, PEG40 stearate and PEG60 hydrogenated castor oil.
Optionally, the hair care conditioner comprises: dodecyl benzene sulfonic acid TEA salt, polydimethylsiloxane, myristamidopropyl PG-dimethyl ammonium chloride phosphate, hydroxypropyl trimethyl ammonium chloride hydrolyzed wheat protein, and radix Gentianae extract.
Optionally, the preservative is one or a mixture of methyl hydroxybenzoate and phenoxyethanol; the pH regulator is one or a mixture of citric acid and sodium citrate.
Optionally, the preparation method of the compound anti-dandruff shampoo comprises the following steps:
(1) weighing the raw materials in proportion;
(2) adding deionized water into a reaction kettle, starting stirring and heating, setting the temperature to be 80-85 ℃, sequentially adding guar hydroxypropyl trimethyl ammonium chloride, polyquaternium-10 and a humectant, keeping the temperature to be completely dissolved, and uniformly mixing to obtain a first mixture;
(3) adding cetearyl alcohol and an antidandruff agent into the first mixture, uniformly stirring, and keeping the temperature at 80 ℃ for 30 minutes to obtain a second mixture;
(3) adding ethylhexyl glycerol, a surfactant and a foam booster into the second mixture, cooling to 60-70 ℃ while stirring, and uniformly mixing after the added substances are completely dissolved to obtain a third mixture;
(4) adding a pH regulator into the third mixture, regulating the pH value to 6.0-6.5, and cooling to 40-50 ℃ to obtain a fourth mixture;
(5) adding panthenol, a hair care conditioner and a thickening agent into the fourth mixture, and uniformly stirring until the panthenol, the hair care conditioner and the thickening agent are completely dissolved to obtain a fifth mixture;
(6) and adding the preservative and the essence into the fifth mixture, and stirring until the preservative and the essence are completely mixed to obtain the compound anti-dandruff shampoo.
The mangnolia officinalis in the invention is a special precious tree species in China, can be planted manually, grows in mountain forests with elevation of 300 plus one year 1500 meters, and needs to be shaded during the juvenile period; pleased in cool, humid, cloudy and foggy climates with high relative humidity. The cortex Magnolia officinalis extract contains magnolol as main active ingredient, and has antibacterial effect on gram-positive bacteria such as Staphylococcus aureus, hemolytic streptococcus, pneumococcus, and Bordetella pertussis, and gram-negative bacteria such as Bacillus anthracis, Bacillus dysenteriae, Salmonella typhi, Bacillus paratyphi, Vibrio cholerae, Escherichia coli, Bacillus proteus, and Bacillus subtilis.
The white willow bark extract contains salicin as main component, and is salicylic acid under acidic condition, which can dissolve acne, control oil and remove acne.
The main functional components of flavone, alkaloid and volatile oil in the lotus leaf extract have high extraction yield and strong inhibition effect on all tested bacteria (including gram-positive bacteria and gram-negative bacteria, cocci and bacilli). The lotus leaf alkaloid has strong bacteriostatic activity, particularly has the most obvious effect of inhibiting bacteria and yeast, but has weak effect of inhibiting mould. This is mainly because the nelumbine has antimitotic effect, and the growth and reproduction of bacteria and yeast are inhibited by mitosis just by the nelumbine as long as the bacteria and yeast are asexually reproduced by fission.
The hexamidine dihydrochloride is beneficial to inhibiting sebum secretion, can promote the synthetic gene expression of skin lipid components and improve the barrier function of skin.
The radix Gentianae extract has effects in inhibiting irritation and resisting inflammation; can promote scalp cell secretion, and has scalp soothing effect.
Compared with the prior art, the invention has the following beneficial effects: the anti-dandruff composition disclosed by the invention uses the traditional anti-dandruff agent and the plant anti-dandruff agent as effective components, has a strong inhibition effect on various bacteria, and is stable in component system. The method has simple and convenient process, the anti-dandruff composition can be simply compounded into a shampoo formula, and the anti-dandruff composition has no stimulation and mildness to human skin and has obvious anti-dandruff and itching-relieving effects.
Detailed Description
The invention is further described below with reference to examples, but the scope of the invention as claimed is not limited to the examples.
The formulations of examples 1 to 3 and comparative examples 1 to 2 of the present invention are as follows:
TABLE 1 data sheet for formulation of different complex anti-dandruff shampoos
The preparation method of the compound anti-dandruff shampoo described in the embodiments 1-3 and the comparative examples 1-2 comprises the following steps:
(1) weighing the raw materials in proportion;
(2) adding deionized water into a reaction kettle, starting stirring and heating, setting the temperature to be 80-85 ℃, sequentially adding guar gum hydroxypropyl trimethyl ammonium chloride, polyquaternium-10, PCA sodium and allantoin, keeping the temperature to be completely dissolved, and uniformly mixing to obtain a first mixture;
(3) adding cetearyl alcohol, cortex Magnolia officinalis extract, folium Nelumbinis extract, cortex Salicis Babylonicae extract, piroctone olamine, climbazole, hydroxyphenylpropionamidobenzoic acid, alanylglutamine, hexamidine dihydrochloride into the first mixture, stirring, and maintaining at 80 deg.C for 30 min to obtain a second mixture;
(3) adding ethylhexyl glycerol, coco-fatty acid polyether ammonium sulfate, sodium cocoyl amphoacetate, ammonium lauryl sulfate, propylene glycol laurate, cocamidopropyl hydroxysultaine, an acrylic acid/VA copolymer and PEG-120 distearate into the second mixture, cooling to 60-70 ℃ while stirring, and completely dissolving and uniformly mixing the added substances to obtain a third mixture;
(4) adding a pH regulator into the third mixture, regulating the pH value to 6.0-6.5, and cooling to 40-50 ℃ to obtain a fourth mixture;
(5) adding panthenol, TEA salt of dodecylbenzene sulfonate, polydimethylsiloxane, myristamidopropyl PG-dimethyl ammonium chloride phosphate, hydrolyzed wheat protein of hydroxypropyl trimethyl ammonium chloride, radix Gentianae extract and PEG-150 distearate into the fourth mixture, and stirring uniformly until completely dissolved to obtain a fifth mixture;
(6) adding phenoxyethanol and essence into the fifth mixture, and stirring to completely mix to obtain the compound anti-dandruff shampoo.
1. Antidandruff test
Test samples: the complex anti-dandruff shampoos of examples 1-3 and comparative examples 1-2.
The evaluation method comprises the following steps: 100 volunteers with dandruff and head itching problem were selected and divided into 5 groups of 20 individuals for testing. During the test period, volunteers in different groups only washed hair with the same shampoo once a day for 28 days, and then counted the number of people with different dandruff grades. The dandruff grades are 5 grades, namely normal (without dandruff), 1 grade (with little dandruff), 2 grade (with light dandruff), 3 grade (with medium dandruff) and 4 grade (with large dandruff).
And (4) evaluation results: the number of people was counted after shampooing, and the results are shown in Table 2. From the evaluation results, the composite anti-dandruff shampoo of the embodiments 1 to 3 of the invention is superior to the comparative examples 1 to 2 in the anti-dandruff effect, wherein the embodiment 3 is the best.
TABLE 2 anti-dandruff data for different complex anti-dandruff shampoos
2. Antipruritic test
Test samples: the complex anti-dandruff shampoos of examples 1-3 and comparative examples 1-2.
The evaluation method comprises the following steps: 100 volunteers with dandruff and head itching problem were selected and divided into 5 groups of 20 individuals for testing. During the test period, volunteers in different groups only washed hair with the same shampoo once a day for 28 days, and then the number of itching people in different time periods is counted.
And (4) evaluation results: the number of people was counted after shampooing, and the results are shown in Table 3. From the evaluation results, the compound anti-dandruff shampoo in the embodiments 1 to 3 of the invention is superior to the comparative examples 1 to 2 in the aspect of itching relieving effect, wherein the embodiment 3 is the best.
TABLE 3 sensory test data for different complex anti-dandruff shampoos
| Time | Example 1 (human) | Example 2 (human) | Example 3 (human) | COMPARATIVE EXAMPLE 1 (human) | COMPARATIVE EXAMPLE 2 (human) |
| D7 | 16 | 14 | 10 | 16 | 18 |
| D14 | 12 | 8 | 2 | 14 | 16 |
| D21 | 6 | 2 | 0 | 12 | 14 |
| D28 | 0 | 0 | 0 | 9 | 10 |
3. Oil control test
Test samples: the complex anti-dandruff shampoos of examples 1-3 and comparative examples 1-2.
The evaluation method comprises the following steps: 100 volunteers with dandruff and head itching problem were selected and divided into 5 groups of 20 individuals for testing. And (3) washing the hair of volunteers in different groups by using the same shampoo in the test period, washing the hair once every day for 28 days continuously, grading the oil control effect of the sample according to the use experience by the volunteers, wherein the grading standard is 10 grades, the higher the grading is, the better the representative effect is, and the average value of the grading result is recorded.
And (4) evaluation results: the oil control effect was scored after shampooing, with the results shown in table 4. From the evaluation results, the compound anti-dandruff shampoo disclosed by the embodiments 1-3 is superior to the comparative examples 1-2 in the aspect of itching relieving effect, wherein the embodiment 3 is the best; comparative example 1 the oil control effect was significantly reduced in the absence of the white willow bark extract component.
TABLE 4 oil control test Effect of different composite anti-dandruff shampoos
| Time | Example 1 | Example 2 | Example 3 | Comparative example 1 | Comparative example 2 |
| D7 | 9.02 | 9.22 | 9.21 | 8.14 | 9.06 |
| D14 | 9.06 | 9.26 | 9.26 | 8.18 | 9.10 |
| D21 | 9.12 | 9.3 | 9.28 | 8.24 | 9.12 |
| D28 | 9.16 | 9.32 | 9.36 | 8.20 | 9.12 |
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.
Claims (10)
1. The compound anti-dandruff shampoo is characterized by comprising the following components in percentage by mass:
2. the compound anti-dandruff shampoo according to claim 1, wherein the moisturizer is one or more of allantoin, sodium PCA, panthenol and ethylhexyl glycerin.
3. The compound anti-dandruff shampoo according to claim 1, wherein the foam booster is one or a mixture of acrylic acid/VA copolymer, cocamidopropyl hydroxysultaine, propylene glycol laurate and PEG-120 distearate.
4. The compound anti-dandruff shampoo according to claim 1, wherein the surfactant is one or more of coco polyether ammonium sulfate, lauryl ammonium sulfate, sodium cocoamphoacetate and cocamide MEA.
5. The compound anti-dandruff shampoo according to claim 1, wherein the anti-dandruff agent is one or more of cortex Magnoliae officinalis extract, folium Nelumbinis extract, white willow bark extract, piroctone olamine, climbazole, hydroxyphenylpropionamidobenzoic acid, alanylglutamine, hexamidine dihydrochloride.
6. The compound anti-dandruff shampoo according to claim 5, wherein the cortex magnoliae officinalis bark extract is: the lotus leaf extract comprises the following components: the white willow bark extract is 1:1: 1.
7. The compound anti-dandruff shampoo according to claim 1, wherein the thickener is one or a mixture of PEG-150 distearate, xanthan gum, guar gum and alginate jelly; the emulsifier is one or more of cetearyl alcohol, PEG40 stearate and PEG60 hydrogenated castor oil.
8. The compound anti-dandruff shampoo according to claim 1, wherein the hair conditioning agents comprise: dodecyl benzene sulfonic acid TEA salt, polydimethylsiloxane, myristamidopropyl PG-dimethyl ammonium chloride phosphate, hydroxypropyl trimethyl ammonium chloride hydrolyzed wheat protein, and radix Gentianae extract.
9. The compound anti-dandruff shampoo according to claim 1, wherein the preservative is one or a mixture of methylparaben and phenoxyethanol; the pH regulator is one or a mixture of citric acid and sodium citrate.
10. The method for preparing a compound anti-dandruff shampoo according to any of claims 1 to 9, characterized in that it comprises the following steps:
(1) weighing the raw materials in proportion;
(2) adding deionized water into a reaction kettle, starting stirring and heating, setting the temperature to be 80-85 ℃, sequentially adding guar hydroxypropyl trimethyl ammonium chloride, polyquaternium-10 and a humectant, keeping the temperature to be completely dissolved, and uniformly mixing to obtain a first mixture;
(3) adding cetearyl alcohol and an antidandruff agent into the first mixture, uniformly stirring, and keeping the temperature at 80 ℃ for 30 minutes to obtain a second mixture;
(3) adding ethylhexyl glycerol, a surfactant and a foam booster into the second mixture, cooling to 60-70 ℃ while stirring, and uniformly mixing after the added substances are completely dissolved to obtain a third mixture;
(4) adding a pH regulator into the third mixture, regulating the pH value to 6.0-6.5, and cooling to 40-50 ℃ to obtain a fourth mixture;
(5) adding panthenol, a hair care conditioner and a thickening agent into the fourth mixture, and uniformly stirring until the panthenol, the hair care conditioner and the thickening agent are completely dissolved to obtain a fifth mixture;
(6) and adding the preservative and the essence into the fifth mixture, and stirring until the preservative and the essence are completely mixed to obtain the compound anti-dandruff shampoo.
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| CN115813841B (en) * | 2023-01-10 | 2023-09-05 | 广东迪美新材料科技有限公司 | Anti-dandruff itching-relieving composition, preparation method and application thereof, shampoo and preparation method |
| CN116869871A (en) * | 2023-08-10 | 2023-10-13 | 广州顶冠生物有限公司 | Anti-dandruff shampoo and preparation method thereof |
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