CN111358712A - Application of chitosan-amino acid gel thickening emollient in face cream - Google Patents
Application of chitosan-amino acid gel thickening emollient in face cream Download PDFInfo
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- CN111358712A CN111358712A CN202010287640.0A CN202010287640A CN111358712A CN 111358712 A CN111358712 A CN 111358712A CN 202010287640 A CN202010287640 A CN 202010287640A CN 111358712 A CN111358712 A CN 111358712A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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Abstract
The invention relates to an application of a chitosan-amino acid gel thickening emollient in face cream, belonging to the field of cosmetics; the thickening emollient is synthesized by chitosan and amino fatty acid; after cleansing, the thickening emollient components in the cream of the invention are decomposed into chitosan and amino fatty acid in the weak acid environment of the skin surface; on one hand, the chitosan absorbs moisture in the microenvironment of the skin to form a thin water mist layer, so that the loss of the moisture of the skin is prevented, and the effects of moistening the skin and keeping the moisture are achieved; on the other hand, the amino fatty acid can remove grease secreted by the skin and prevent skin metabolites from blocking pores; the cream disclosed by the invention can balance water balance of skin microenvironment and remove grease secreted by skin, and has the functions of moisturizing and whitening.
Description
Technical Field
The invention relates to an application of a chitosan-amino acid gel thickening emollient in face cream, belonging to the field of cosmetics.
Technical Field
Skin care is a good practice because the skin of a human body is easily exposed to various problems such as chapped skin, dermatitis, itching and chloasma with the aging and the influence of the external environment, and the skin is easily loosened due to the aging and is easily damaged by ultraviolet rays.
The traditional facial skin care product contains more chemical components. Such as propylene glycol, which is obtained from petrochemical processes and which provides skin with a smooth finish, but also accelerates the rate of skin aging, leading to irritation and skin disorders known as contact dermatitis. For another example, sodium lauryl sulfate is used as an emulsifier, and has a tendency to be absorbed by the skin and accumulate in various body organs. In addition, it contains more mineral oil, which causes skin irritation and blocks sweat pores, and it also hinders the activity of nutrients. At present, a pure natural skin care technical scheme is lacked.
The cream has thicker texture than lotion, and higher nutrient content than lotion, and has the main functions of forming natural sebum membrane on the epidermis of skin, supplementing water and nutrient components to skin, and repairing damaged cells of the epidermis of skin.
Glutamine (Glutamine) regulates the acid-base balance of the body, and in acidosis or hunger, the net intake and release of Glutamine from the body is unbalanced, providing Glutamine to buffer the acid load. Can promote skin health. Chitosan, an important raw material for cosmetics, has functions of protecting, stabilizing the structure and absorbing shock in a weak acid environment of dermis and epidermis. Chitosan is an important component of the dermal matrix, which acts as a connective tissue support and water retention material. Chitosan in the skin and applied externally plays a key role in connective tissue, achieving a fuller, firmer and younger state of the skin.
Disclosure of Invention
In order to solve the defects, the invention discloses the application of the chitosan-amino acid gel thickening emollient in the face cream, the chitosan-amino acid gel thickening emollient can be decomposed into chitosan and amino acid under an acidic condition, the effects of the chitosan and the amino acid are exerted, the effect of protecting the skin is exerted, and the addition of an emulsifier is reduced.
The invention aims to provide a preparation method of a chitosan-amino acid gel thickening emollient.
Another object of the present invention is to provide a use of chitosan-amino acid gel thickening emollient in a cream.
The present invention is achieved in the following manner.
The face cream comprises the following components in percentage by weight:
50-60 parts of water, 100.3-1.2 parts of conditioner polyquaternium, 0.1-0.25 part of allantoin, 0.2-0.4 part of citric acid, 0.1-0.2 part of chelating agent, 0.1-0.5 part of emollient, 2-3 parts of skin conditioner, 4-6 parts of humectant, 0.1-0.5 part of emulsion stabilizer, 0.2-0.4 part of essence, 0.2-0.4 part of preservative, 3.5-6.9 parts of chitosan-amino acid gel thickening emollient, and acid-base regulator NaHCO3And K2CO33-5 parts of acetyl tetrapeptide-9: 1-3 parts of jojoba oil, 2-6 parts of jojoba oil and 1-5 parts of polydimethylsiloxane.
The skin conditioner is a compound of hydrolyzed sericin, olive oil PEG-7 esters, panthenol and plant extracts.
The chelating agent is one or a combination of sodium citrate and glucose delta lactone.
The emollient is one or a combination of myristyl myristate, octyl caprylate, oleyl oleate and coconut oil.
The hair conditioner of the invention comprises the following components: one or a combination of behenyl PEG isostearyl ammonium chloride, sodium cocoamidopropyl PG-dimethyl ammonium chloride phosphate and long alkyl cation quaternary ammonium salt.
The humectant of the invention is: glycerin, 1, 2-propylene glycol, 1, 3-butylene glycol, sorbitol, hyaluronic acid or their combination.
The emulsion stabilizer of the invention is: one or a combination of monostearyl fatty acid glyceride, polyglycerol ester, carrageenan, guar gum and sodium pyrophosphate.
The preservative of the invention is: one or a combination of methyl chloro isothiazolinone, methyl isothiazolinone, nipagin ester, phenoxyethanol and benzyl alcohol.
The chitosan-amino acid hydrogel is composed of chitosan and amino fatty acid, and the structural formula of the chitosan-amino acid hydrogel is shown as a formula (I).
Wherein m is 1-5. Wherein o is 3-10. Wherein n is 10-20.
The structural formula of the chitosan is shown as formula (II):
wherein n is 10-20.
The amino fatty acid of the invention is of formula (III):
wherein m is 1-5.
The preparation method of the chitosan-amino acid hydrogel comprises the following steps:
the preparation method of the compound with the structure of the formula (I) comprises the following steps: dissolving 2.0-8.0 g of (II) in 150-600 mL of deionized water, then placing the mixture into a water bath kettle at room temperature for magnetic stirring, dropwise adding 5-30 mL of 15% EDC and DNAP solution when the (II) is completely dispersed in water, activating amino to be active amino, then adding 4-24 g of (III), continuing stirring for 8-24 h in ice-water bath, dialyzing the obtained solution (I) for 24h after the reaction is finished, changing water every 2-8 h (the cut-off molecular weight of a dialysis bag is 2000-3000), and finally performing vacuum freeze drying on the solution (I) in the dialysis bag to obtain the amino acid hydrogel powder (I).
The preparation steps of the chitosan-amino acid hydrogel of the invention are preferably as follows:
dissolving 2g of (II) in 200mL of deionized water, then placing the deionized water in a water bath kettle at room temperature for magnetic stirring, dropwise adding 20mL of 15% EDC and DNAP solution when the (II) is completely dispersed in water, activating the activated amino into active amino, then adding 5g of (III), continuing stirring for 4-6 h in an ice water bath, dialyzing the obtained solution (I) for 24h after the reaction is finished, changing water every 4h (the cut-off molecular weight of a dialysis bag is 2000-3000), and finally, carrying out vacuum freeze drying on the solution (I) in the dialysis bag to obtain the amino acid hydrogel powder (I).
The preparation method of the chitosan-amino acid gel thickening emollient in the face cream comprises the following steps:
step 1, adding water according to the formula amount, stirring, slowly adding a conditioner according to the formula amount, dispersing until no particles exist, adding citric acid according to the formula amount, and stirring until the mixture is uniform.
And 2, mixing the chelating agent and the emollient with the formula amount, heating to 55-65 ℃, stirring for dissolving, adding the solution obtained by the treatment in the step 1, stirring uniformly, heating to 65-70 ℃, keeping the temperature and stirring for 0.5-1 hr.
And 3, adding the skin conditioner, the humectant, the emulsion stabilizer, the essence and the preservative in the formula amount into the solution treated in the step 2, stirring uniformly, adding the amino acid gel thickening emollient in the formula amount, and adding the acid-base regulator in the formula amount to obtain the skin care product.
The thickened emollients of the present invention are useful for reducing the loss of skin moisture.
The thickening emollient provided by the invention is used for whitening skin.
Has the advantages that:
the gel thickening emollient removes the traditional inorganic salt and chemically synthesized thickening emollient, and adopts natural biological agent to synthesize the thickening emollient, and the thickening emollient has the emulsification effect and reduces the addition of emulsifier which has larger harm to skin; the thickening emollient of the invention is rich in hydroxyl, carboxyl and amino, and can be rapidly combined with hydrogen bonds such as hydrogen of lubricant, humectant and the like in the cream to form a similar macromolecular compound after being added into the cream, thereby achieving the thickening effect.
The gel thickening emollient is stable under the condition of weak alkalinity, can stably exist in a weak alkaline environment (pH value of 7-7.5) after being added with an acid-base regulator, is coated on the surface of skin after being cleaned, is partially decomposed into chitosan and fatty acid under the weak acidic environment (pH value of 6.5-7.0) of the skin, plays a role in moisturizing and whitening, is partially retained on the surface of the skin to form a protective film so as to further protect the skin from external damage, and has strong repairing capability.
The following will clearly and completely describe the technical scheme of the embodiment of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1 preparation of chitosan-amino acid gel thickening emollient 1:
dissolving 2.0-8.0 g of (II) in 150-600 mL of deionized water, then placing the mixture into a water bath kettle at room temperature for magnetic stirring, dropwise adding 5-30 mL of 15% EDC and NHS solution when the (II) is completely dispersed in water, activating the activated amino into active amino, then adding 4-24 g of (III), continuing stirring for 8-24 h in an ice-water bath, dialyzing the obtained solution (I) for 24h after the reaction is finished, changing water every 2-8 h (the cut-off molecular weight of a dialysis bag is 2000), and finally performing vacuum freeze drying on the solution (I) in the dialysis bag to obtain the chitosan-amino acid hydrogel powder (I).
Example 2 preparation of chitosan-amino acid gel thickening emollient 2:
dissolving 2g of (II) in 200mL of deionized water, then placing the mixture into a water bath kettle at room temperature for magnetic stirring, dropwise adding 20mL of 15% EDC and NHS solution when the (II) is completely dispersed in water, activating the activated amino into active amino, then adding 5g of (III), continuing stirring for 12-15 h in an ice water bath, dialyzing the obtained solution (I) for 24h after the reaction is finished, changing water every 4h (the molecular weight cut-off of a dialysis bag is 2000), and finally, carrying out vacuum freeze drying on the solution (I) in the dialysis bag to obtain the chitosan-amino acid hydrogel powder (I).
Example 3 preparation of chitosan-amino acid gel cream 1:
50-60 parts of water, 100.3-1.2 parts of conditioner polyquaternium, 0.1-0.25 part of allantoin, 0.2-0.4 part of citric acid, 0.1-0.2 part of chelating agent, 0.1-0.5 part of emollient, 2-3 parts of skin conditioner, 4-6 parts of humectant, 0.1-0.5 part of emulsion stabilizer, 0.2-0.4 part of essence, 0.2-0.4 part of preservative, 3.5-6.9 parts of chitosan-amino acid gel thickening emollient, and acid-base regulator NaHCO3And K2CO33-5 parts of acetyl tetrapeptide-9: 1-3 parts of jojoba oil, 2-6 parts of jojoba oil and 1-5 parts of polydimethylsiloxane.
The skin conditioner is a compound of hydrolyzed sericin, olive oil PEG-7 esters, panthenol and plant extracts.
The chelating agent is one or a combination of sodium citrate and glucose delta lactone.
The emollient is one or a combination of myristyl myristate, octyl caprylate, oleyl oleate and coconut oil.
The hair conditioner of the invention comprises the following components: one or a combination of behenyl PEG isostearyl ammonium chloride, sodium cocoamidopropyl PG-dimethyl ammonium chloride phosphate and long alkyl cation quaternary ammonium salt.
The humectant of the invention is: glycerin, 1, 2-propylene glycol, 1, 3-butylene glycol, sorbitol, hyaluronic acid or their combination.
The emulsion stabilizer of the invention is: one or a combination of monostearyl fatty acid glyceride, polyglycerol ester, carrageenan, guar gum and sodium pyrophosphate.
The preservative of the invention is: one or a combination of methyl chloro isothiazolinone, methyl isothiazolinone, nipagin ester, phenoxyethanol and benzyl alcohol.
The structural formula of the chitosan-amino acid gel thickening emollient is shown as (I):
wherein m is 1-5. Wherein o is 3-10. Wherein n is 10-20.
The preparation was as described in example 7.
Example 4 preparation of chitosan-amino acid gel cream 2:
55-58 parts of water, 100.5-0.8 part of conditioner polyquaternium, 0.15-0.20 part of allantoin, 0.3-0.4 part of citric acid, 0.15-0.2 part of chelating agent, 0.2-0.4 part of emollient, 2-3 parts of skin conditioner, 4-6 parts of humectant, 0.2-0.4 part of emulsion stabilizer, 0.2-0.3 part of essence, 0.2-0.3 part of preservative, 4.5-6.0 parts of chitosan-amino acid gel, and acid-base regulator NaHCO3And K2CO34-5 parts of acetyl tetrapeptide-9: 1-2 parts of ageratum3-6 parts of base oil and 1-3 parts of polydimethylsiloxane.
The skin conditioner is a compound of hydrolyzed sericin, olive oil PEG-7 esters, panthenol and plant extracts.
The chelating agent is one or a combination of sodium citrate and glucose delta lactone.
The emollient is one or a combination of myristyl myristate, octyl caprylate, oleyl oleate and coconut oil.
The hair conditioner of the invention comprises the following components: one or a combination of behenyl PEG isostearyl ammonium chloride, sodium cocoamidopropyl PG-dimethyl ammonium chloride phosphate and long alkyl cation quaternary ammonium salt.
The humectant of the invention is: glycerin, 1, 2-propylene glycol, 1, 3-butylene glycol, sorbitol, hyaluronic acid or their combination.
The emulsion stabilizer of the invention is: one or a combination of monostearyl fatty acid glyceride, polyglycerol ester, carrageenan, guar gum and sodium pyrophosphate.
The preservative of the invention is: one or a combination of methyl chloro isothiazolinone, methyl isothiazolinone, nipagin ester, phenoxyethanol and benzyl alcohol.
The preparation was as described in example 7.
Example 5 preparation of chitosan-amino acid gel cream 3:
55 parts of water, 100.6 parts of conditioner polyquaternium, 0.15 part of allantoin, 0.3 part of citric acid, 0.15 part of chelating agent, 0.3 part of emollient, 2.5 parts of skin conditioner, 5 parts of humectant, 0.3 part of emulsion stabilizer, 0.3 part of essence, 0.3 part of preservative, 4.5 parts of chitosan-amino acid gel thickening emollient, and acid-base regulator NaHCO3And K2CO33 parts, acetyl tetrapeptide-9: 1 part, 2 parts of jojoba oil and 2 parts of polydimethylsiloxane.
The skin conditioner is a compound of hydrolyzed sericin, olive oil PEG-7 esters, panthenol and plant extracts.
The chelating agent is one or a combination of sodium citrate and glucose delta lactone.
The emollient is one or a combination of myristyl myristate, octyl caprylate, oleyl oleate and coconut oil.
The hair conditioner of the invention comprises the following components: one or a combination of behenyl PEG isostearyl ammonium chloride, sodium cocoamidopropyl PG-dimethyl ammonium chloride phosphate and long alkyl cation quaternary ammonium salt.
The humectant of the invention is: glycerin, 1, 2-propylene glycol, 1, 3-butylene glycol, sorbitol, hyaluronic acid or their combination.
The emulsion stabilizer of the invention is: one or a combination of monostearyl fatty acid glyceride, polyglycerol ester, carrageenan, guar gum and sodium pyrophosphate.
The preservative of the invention is: one or a combination of methyl chloro isothiazolinone, methyl isothiazolinone, nipagin ester, phenoxyethanol and benzyl alcohol.
The preparation was as described in example 7.
Example 6 preparation of a normal cream:
55 parts of water, 100.6 parts of conditioner polyquaternium, 0.15 part of allantoin, 0.3 part of citric acid, 0.15 part of chelating agent, 0.3 part of emollient, 2.5 parts of skin conditioner, 5 parts of humectant, 0.3 part of emulsion stabilizer, 0.3 part of essence, 0.3 part of preservative, and acid-base regulator NaHCO3And K2CO33 parts, acetyl tetrapeptide-9: 1 part, 2 parts of jojoba oil and 2 parts of polydimethylsiloxane.
The skin conditioner is a compound of hydrolyzed sericin, olive oil PEG-7 esters, panthenol and plant extracts.
The chelating agent is one or a combination of sodium citrate and glucose delta lactone.
The emollient is one or a combination of myristyl myristate, octyl caprylate, oleyl oleate and coconut oil.
The hair conditioner of the invention comprises the following components: one or a combination of behenyl PEG isostearyl ammonium chloride, sodium cocoamidopropyl PG-dimethyl ammonium chloride phosphate and long alkyl cation quaternary ammonium salt.
The humectant of the invention is: glycerin, 1, 2-propylene glycol, 1, 3-butylene glycol, sorbitol, hyaluronic acid or their combination.
The emulsion stabilizer of the invention is: one or a combination of monostearyl fatty acid glyceride, polyglycerol ester, carrageenan, guar gum and sodium pyrophosphate.
The preservative of the invention is: one or a combination of methyl chloro isothiazolinone, methyl isothiazolinone, nipagin ester, phenoxyethanol and benzyl alcohol.
EXAMPLE 7 preparation of Chitosan-amino acid gel thickening emollient in cream
Step 1, adding water according to the formula amount, stirring, slowly adding a conditioner according to the formula amount, dispersing until no particles exist, adding citric acid according to the formula amount, and stirring uniformly;
step 2, mixing the chelating agent and the emollient with the formula amount, heating to 55-65 ℃, stirring for dissolving, adding the solution obtained by the step 1, stirring uniformly, heating to 65-70 ℃, keeping the temperature and stirring for 0.5-1 hr;
and 3, adding the skin conditioner, the humectant, the emulsion stabilizer, the essence and the preservative in the formula amount into the solution treated in the step 2, stirring uniformly, adding the amino acid gel thickening emollient in the formula amount, and adding the acid-base regulator in the formula amount to obtain the skin care product.
EXAMPLE 8 Chitosan-amino acid gel thickening emollient for whitening cream
1. Test products: examples 3-5 prepared a cream containing a chitosan-amino acid gel thickening emollient lotion and a conventional cream prepared in example 6.
2. A population of test persons; sex number: 100 people with a male to female ratio of about 1: 1; age: between 12 and 30 years old; health condition: the skin of the subject is healthy, has no allergic history of the skin disease, and meets the voluntary selection standard of the subject.
Grouping: divided into 4 groups of 25 people each, with a mean age of 25 ± 2 years.
3. The test method comprises the following steps: the use effect was observed and felt using the chitosan-amino acid gel thickening emollient cream prepared in examples 3 to 5 and the general cream of example 6, respectively. The using method comprises the following steps: the subjects respectively apply an appropriate amount of the cream containing chitosan-amino acid gel thickening emollient prepared in examples 3 to 5, the common cream of example 6, on the face uniformly, and massage for 1 to 2 min. The medicine is taken once a day, morning and evening, and is used for one month, and is checked at least once a week to know whether systemic and local adverse reactions exist, and the result is recorded in detail.
The results of the test evaluation are shown in Table 1
Evaluation indexes are as follows: 1) whitening effect; 2) degree of wetness; 3) smoothness; 4) and (5) removing acne marks.
Evaluation coefficient: 1-10; the worst is 1, and the best is 10.
TABLE 1 comparative (one month) feedback summary of hyaluronic acid-amino acid gel-thickening emollient-containing creams prepared in examples 3-5 and conventional cream in example 6
| Evaluation item | Whitening effect | Degree of wetness | Smoothness of the surface | Acne mark fading device |
| Example 3 | 9 | 9 | 10 | 8 |
| Example 4 | 10 | 8 | 9 | 9 |
| Example 5 | 8 | 10 | 10 | 8 |
| Example 6 | 4 | 5 | 6 | 5 |
As can be seen from Table 1, the cream containing the chitosan-amino acid gel thickening emollient prepared in the examples 3 to 5 is widely accepted and favored by the subjects, and the subjects all show that the cream containing the chitosan-amino acid gel thickening emollient prepared in the examples 3 to 5 has mild texture, improves the skin moisture, reduces acne marks, deeply repairs and conditions the acne skin. Example 6 behaves ordinarily.
EXAMPLE 9 preparation of Chitosan-amino acid gel thickening emollient
Dissolving 2g of (II) in 200mL of deionized water, then placing the deionized water in a water bath kettle at room temperature for magnetic stirring, dropwise adding 20mL of 15% EDC and DNAP solution when the (II) is completely dispersed in water, activating the activated amino into active amino, then adding 5g of (III), continuing stirring for 4-6 h in an ice water bath, dialyzing the obtained solution (I) for 24h after the reaction is finished, changing water every 4h (the cut-off molecular weight of a dialysis bag is 2000-3000), and finally, carrying out vacuum freeze drying on the solution (I) in the dialysis bag to obtain the amino acid hydrogel powder (I).
Claims (3)
1. The application of the chitosan-amino acid gel thickening emollient in the face cream is characterized in that the proportion of the face cream is as follows:
50-60 parts of water, 100.3-1.2 parts of conditioner polyquaternium, 0.1-0.25 part of allantoin, 0.2-0.4 part of citric acid, 0.1-0.2 part of chelating agent, 0.1-0.5 part of emollient, 2-3 parts of skin conditioner, 4-6 parts of humectant, 0.1-0.5 part of emulsion stabilizer, 0.2-0.4 part of essence, 0.2-0.4 part of preservative, 3.5-6.9 parts of chitosan-amino acid gel thickening emollient, and acid-base regulator NaHCO3And K2CO33-5 parts of acetyl tetrapeptide-9: 1-3 parts of jojoba oil, 2-6 parts of jojoba oil and 1-5 parts of polydimethylsiloxane;
the skin conditioner is a compound of hydrolyzed sericin, olive oil PEG-7 esters, panthenol and plant extracts;
the chelating agent is one or a combination of sodium citrate and glucose delta lactone;
the emollient is one or a combination of myristyl myristate, octyl caprylate, oleyl oleate and coconut oil;
the hair conditioner comprises the following components: one or a combination of behenyl PEG isostearyl ammonium chloride, sodium cocoamidopropyl PG-dimethyl ammonium chloride phosphate and long alkyl cation quaternary ammonium salt;
the humectant is as follows: one or a combination of glycerol, 1, 2-propylene glycol, 1, 3-butylene glycol, sorbitol and hyaluronic acid;
the emulsion stabilizer comprises: one or a combination of monostearyl fatty acid glyceride, polyglycerol ester, carrageenan, guar gum and sodium pyrophosphate;
the preservative is as follows: one or a combination of methyl chloro isothiazolinone, methyl isothiazolinone, nipagin ester, phenoxyethanol and benzyl alcohol;
the structural formula of the chitosan-amino acid gel thickening emollient is shown as (I);
wherein m is 1-5; wherein o is 3-10; wherein n is 10-20;
the preparation method of the chitosan-amino acid gel thickening emollient in the face cream comprises the following steps:
step 1, adding water according to the formula amount, stirring, slowly adding a conditioner according to the formula amount, dispersing until no particles exist, adding citric acid according to the formula amount, and stirring uniformly;
step 2, mixing the chelating agent and the emollient with the formula amount, heating to 55-65 ℃, stirring for dissolving, adding the solution obtained by the step 1, stirring uniformly, heating to 65-70 ℃, keeping the temperature and stirring for 0.5-1 hr;
and 3, adding the skin conditioner, the humectant, the emulsion stabilizer, the essence and the preservative in the formula amount into the solution treated in the step 2, stirring uniformly, adding the amino acid gel thickening emollient in the formula amount, and adding the acid-base regulator in the formula amount to obtain the skin care product.
2. A chitosan-amino acid gel thickening emollient for use in facial cream as claimed in claim 1 wherein: the thickened emollient is useful for reducing the loss of moisture from the skin.
3. A chitosan-amino acid gel thickening emollient for use in facial cream as claimed in claim 1 wherein: the thickening emollient is used for whitening skin.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112370392A (en) * | 2020-12-02 | 2021-02-19 | 上海珈凯生物科技有限公司 | Green tangerine peel-containing irritation relieving composition and preparation method thereof |
| CN112898450A (en) * | 2021-01-27 | 2021-06-04 | 张才来 | Preparation method and application of phloretin derivative sustained-release preparation |
| CN112891320A (en) * | 2021-01-27 | 2021-06-04 | 张才来 | Application of phloretin derivative sustained-release preparation in long-acting antibacterial drugs |
-
2020
- 2020-04-13 CN CN202010287640.0A patent/CN111358712A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112370392A (en) * | 2020-12-02 | 2021-02-19 | 上海珈凯生物科技有限公司 | Green tangerine peel-containing irritation relieving composition and preparation method thereof |
| CN112898450A (en) * | 2021-01-27 | 2021-06-04 | 张才来 | Preparation method and application of phloretin derivative sustained-release preparation |
| CN112891320A (en) * | 2021-01-27 | 2021-06-04 | 张才来 | Application of phloretin derivative sustained-release preparation in long-acting antibacterial drugs |
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