JP2694756B2 - Cosmetics containing divalent and trivalent iron salts - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention relates to cosmetics containing divalent and trivalent iron salts having biologically extremely interesting actions such as bioactive action, ionization inhibiting action and antiseptic action. Is.

[Conventional technology]

According to the Pharmaceutical Affairs Law, cosmetics means "to clean the human body,
It is intended to be applied to the body by rubbing, dusting or similar in order to beautify, increase the attractiveness, change the appearance, or keep the skin or hair healthy. The effect on the skin and hair is beautifully adjusted artificially or artificially. For that, lotion,
A great variety of products such as emulsions, creams, shampoos, rinses, hair tonics or lipsticks, foundations are on the market. Furthermore, in order to further clarify the effects of each cosmetic, various moisturizers, oils and fats components, surfactants, fragrances, pigments and other natural and synthetic raw materials are used.
A tentative effect is obtained by each compounding ingredient.

However, due to the recent environmental pollution or the accumulation of social stress, the original physiological function of the skin has deteriorated, and troubled skin such as rough skin, dry skin, and sensitive skin, and abnormal hair such as hair loss and whitening are very noticeable. Is coming. When conventional cosmetics are used in such a state, the physiological function of the skin is further deteriorated, and the troubles caused by the cosmetics for that purpose are extremely increased.

[Problems to be Solved by the Invention] From the viewpoint of the substance of such a cosmetic, it is desired to develop a cosmetic that restores the original physiological function of the skin and yet sufficiently satisfies the definition of the cosmetic under the Pharmaceutical Affairs Law. . To solve this problem, it has not been possible to achieve it by only the direct effects of the individual components of cosmetics that have been studied in the past. For example, moisturizer hyaluronic acid or water-soluble protein for the purpose of rehydrating dry skin, or stain removal, vitamin C derivative for whitening, etc. Various problems remain in terms of the sustainability of the effect or skin irritation due to the deterioration of the components after application, and the effect of restoring the original physiological function of the skin has not been improved.

[Means for solving the problem]

In view of the above-mentioned circumstances, the present inventor can safely use it for troubled skin such as rough skin and sensitive skin, and has normal physiological functions such as defense function, respiratory function, excretion and secretory function that the skin originally has. We have earnestly conducted research on cosmetics that can be recovered. As a result, only the cosmetics containing the specific divalent and trivalent iron salts have the effects of conventional cosmetics, and further enhance the skin function, enhance the regeneration ability, and strengthen the resistance to irritants caused by environmental pollution. , It has been found that it becomes possible to perform the normal metabolic functions of the skin, which were not desired in conventional cosmetics, such as prevention of microbial contamination and prevention of harmful ionic reactions.

That is, the present invention relates to a cosmetic product containing the divalent and trivalent iron salt having the above object.

 Hereinafter, the present invention will be described in detail.

The divalent and trivalent iron salts used in the cosmetics of the present invention are inorganic salts and formates of iron hydrochloride, sulfate, phosphate, nitrate, etc., which exhibit intermediate properties between divalent iron salts and trivalent iron salts. There are organic salts such as acetate and propionate. For example, known compounds include complex salts of divalent iron and trivalent iron such as Fe ₃ Cl ₇ · XH ₂ O · Fe ₃ Cl ₈ · XH ₂ O, but the most preferred divalent trivalent in the present invention. As the iron salt, Japanese Patent Laid-Open No. 59-19 of the present inventors
Fe ₂ C described in 0226 and JP-A-60-196581
l ₇ · XH ₂ O can be mentioned.

When these divalent and trivalent iron salts are dissolved in water or rubbed on a water-containing surface such as the skin surface, they inhibit various ionic reactions and induce a reaction significantly different from the ionic reaction in a normal water system. By applying the divalent and trivalent iron salt-containing cosmetics of the present invention, the normal nonionic reaction system in the living body can be recovered and the living body can be returned to the normal state.

When blending the above divalent and trivalent iron salts in cosmetics, depending on the properties of the cosmetic, the type of compounding agent and the intended effect, not only the divalent and trivalent iron salts are blended alone, but sodium chloride, for example, Inorganic substances such as sodium sulphate, ammonium chloride, ammonium sulphate, magnesium chloride, diatomaceous earth, bentonite, silica and alumina, and organic substances such as vegetable fiber, pulp, vitamins, hormones, proteins and lipids as carriers Most preferably, it is used by supporting it.

The amount of divalent and trivalent iron salts, including the carrier, is a cosmetic base.
10 ^-5 to 10 ^-15 g per 100 g, preferably 10 ^-9 to 10 ^-12 g
Range. The effect of divalent and trivalent iron salts is diminished if the compounding amount is more or less than this range.

Examples of cosmetics in which the present invention can be carried out by blending divalent and trivalent iron salts are basic cosmetics such as lotion, emulsion, cream, pack, cosmetic oil, hair cosmetics such as shampoo, hair tonic, hair restorer, and the like. It can be applied to almost all cosmetics such as makeup cosmetics such as lipsticks, foundations and blushers. However, in consideration of the shape and uniform dispersibility of cosmetics, a water-soluble or water-dispersible carrier,
It is necessary to select and use oil dispersible carriers and powder carriers.

A wide range of pH from 3 to 11 is applicable to the cosmetics used, but pH 5 to 8 is the most preferable pH range.

The cosmetics of the present invention contain solvents, fats and oils, surfactants, preservatives, fragrances, pigments, etc., which are usually used for makeup, but the amount of divalent and trivalent iron salts is extremely high. Since the amount is very small, when the chelating agent, phenols, mercaptans, cation activator, etc. reactive with the iron salt are mixed as the raw material or as the impurities, the effect of the divalent and trivalent iron salt of the present invention can be obtained. Since it cannot be added to cosmetics, it is necessary to carefully check it beforehand.

Various methods such as the bioassay method can be considered as a method for checking the ability of the divalent and trivalent iron salts to inhibit the ionic reaction, but the following method is the simplest method.

As an ionic reaction inhibition test for cosmetics, the cosmetic base as it is or diluted with purified water, or an aqueous phase portion extracted with purified water is used as a sample, a suitable amount of reagent copper powder is added and dispersed, and then a nitric acid test solution is added. In the case of ordinary cosmetics, naturally copper powder reacts with nitric acid to generate H ₂ gas, and the liquid turns blue due to the production of copper nitrate, but the divalent and trivalent iron salt has the ability to inhibit ionic reactions. In the case of a cosmetic product having, the liquid is colorless and no generation of H ₂ gas is observed, but this is probably because the dissolution of copper powder and the ionic reaction force do not proceed.

Similarly, by adding an appropriate amount of divalent trivalent iron salt to the aqueous solution of the cosmetic raw material or the liquid extracted with purified water for the insoluble raw material to cause the color reaction of copper inon, the divalent trivalent trivalent of the cosmetic raw material is performed. It is possible to test iron salt compatibility.

By the above-mentioned method, the compatibility of the divalent and trivalent iron salts of the raw material is checked in advance, then the cosmetic is manufactured, and then the copper ion formation reaction of the manufactured cosmetic is checked again to obtain the divalent value of the cosmetic. It is possible to confirm the effect of the trivalent iron salt.

〔The invention's effect〕

As described above, the cosmetic containing the divalent and trivalent iron salt of the present invention is
When applied to the skin, the following effects are recognized by the action of normalizing the function of the living body.

(1) Enhancement of skin function Physiological functions originally possessed by skin tissues, that is, normal keratin metabolism of the epidermis, skin secretion, and control of skin surface condition by normalization of water transpiration, and further hair matrix and It is possible to directly promote the normalization of the skin originally possessed by the living body, such as normal growth of hair due to normal metabolism of pigment cells and proper distribution of pigment.

(2) Enhancement of regenerative ability Skin tissue has the ability to restore normal conditions of metabolic function disorder, damage of stratum corneum due to external environment, and deterioration of skin surface due to abnormality of excess and deficiency of skin and water. However, by applying the cosmetics of the present invention, this regeneration function can be strengthened and recovered more quickly. For example, the prognosis of hair loss reproduction, whitening of the hair, inflammation, etc., or normalization of abnormal hyperkeratosis of the keratin such as progressive palmar keratoses,
Removal of spots due to pigmentation and recovery of epidermal abnormalities caused by lack of sebum membranes such as cracks and red fins are quickly achieved.

(3) Enhancement of adaptability to environmental changes It is possible to maintain the original protective function of the skin by enhancing the adaptability of the skin to external stimulants, cold, heat and UV rays. For example, sensitizing skin disorders can be prevented by suppressing the invasion of antigenic substances from the outside. In addition, it is possible to protect the skin in a beautiful state by promoting the formation of a sebum film in accordance with the external environment.

(4) Prevention of abnormal growth of microorganisms It is possible to eliminate or prevent skin troubles such as inflammation and purulence due to abnormal growth of adherent microorganisms and skin-resident bacteria from the outside. For example, it is possible to prevent skin abnormalities resulting from the growth of microorganisms such as acne, armpits, dander on the scalp of the hair, and Kayumi.

In addition, by incorporating the divalent and trivalent iron salt, the preservative that is usually blended in cosmetics becomes unnecessary, and the sensitizing skin disorder caused by the preservative can be prevented.

(5) Prevention of harmful ionic reactions Skin aging, hair loss, by controlling harmful ionic reactions and free radical reactions such as skin irritation by external chemical substances and formation of lipid peroxide of sebum components by UV irradiation. It is possible to prevent whitening.

Further, by mixing the divalent and trivalent iron salt, oxidative deterioration of the oil and fat-containing cosmetics can be prevented, so that an antioxidant for oils and fats, which easily causes a sensitizing skin disorder, becomes unnecessary.

The cosmetics according to the present invention have extremely excellent effects not seen in conventional cosmetics in that in addition to the effect as individual cosmetics due to various compounding ingredients, the above-mentioned 5 items are expected to have indispensable merits for the living body. Can be demonstrated.

〔Example〕

Next, the effects of the present invention will be specifically shown with reference to Examples and Comparative Examples, but the present invention is not limited to these Examples.

 In addition, the compounding amount in the following examples is% by weight.

Example 1. Toner lotion Ethyl alcohol 5.0% Glycerin 5.0% Sodium pyrrolidonecarboxylate 0.5% Nikkor bifamine (Nikko Chemical's amino acid mixture) 0.2% Perfume suitable amount Fe ₂ Cl ₅ · XH ₂ O (neutral lipid carrier) 10 ^-12 % (As Fe ₂ Cl ₅ ) Add purified water to make the total amount 100.0%.

To is added to the production method and dissolved by stirring, and this is filtered to obtain a lotion.

Comparative Example 1. The same formulation as in Example 1 is used to prepare a cosmetic product from which divalent and trivalent iron salts have been removed.

When lotion of Examples and Comparative Examples are subjected to an ionization reaction test by adding copper powder and nitric acid as samples, respectively, H ₂ gas is generated in the Comparative Example, and a blue color reaction of copper nitrate is observed. In the examples, the reaction did not proceed, and it was confirmed that the lotion had the effect of inhibiting the ionic reaction by the divalent and trivalent iron salts.

As a result of a panel test conducted by 50 monitors on this lotion, the moisturizing effect was higher than that of the comparative example, and a remarkable improvement of dry skin was observed.

Example 2. Milky lotion Liquid paraffin 2.0% Squalane 3.0% Glycerin 7.0% Polyoxyethylene monostearate 1.0% Sorbitan sesquioleate 0.3% Carboxyvinyl polymer 0.2% Potassium hydroxide 0.1% Perfume Suitable amount Fe ₂ Cl ₅ · XH ₂ O and 100.0% total volume added (neutral lipid carrier) 10 ^-12% (as Fe ₂ Cl ₅₎ purified water.

Disperse the manufacturing method into, neutralize by adding, and further dissolve and evenly heat the dispersed material to 70 ° C, add to this by heating and dissolving ~ to 70 ° C, and emulsify, After preparing the emulsified particles with a homogenizer, stir and cool to 40 ℃.
After adding, the mixture is stirred to room temperature to obtain a milky lotion.

Comparative Example 2. A milky lotion is prepared by removing the divalent and trivalent iron salts by the same formulation and manufacturing method as in Example 2.

Regarding the milky lotion of Examples and Comparative Examples, an ionization reaction test with copper powder and nitric acid was carried out on the aqueous phase part where the fat and oil components and the free resin component were separated by acidifying both of them, and the milky lotion of the example was attributed to copper ions. It was confirmed that the milky lotion has no coloration and has the effect of inhibiting the ionic reaction by the divalent and trivalent iron salts.

As a result of a panel test conducted by 50 monitors, the milky lotion of the example did not cause irritation to dry skin such as xerosis, had a high moisturizing effect, and reduced the skin dryness and itchiness.

Example 3. Cosmetic cream Polyoxyethylene monostearate 10.0% Glycerin monostearate 5.0% Beeswax 1.0% Liquid paraffin 4.0% Silicon oil 4.0% Glycerin 15.0% Aminomethylpropanol 0.2% Fragrance Suitable amount Fe ₂ Cl ₇ · XH ₂ O and 100.0% total volume added (neutral lipid carrier) 10 ^-12% (as Fe ₂ Cl ₅₎ purified water.

Manufacturing method is heated to 70 ℃, and are heated and dissolved at 70 ℃, stirred and added to emulsify, prepare emulsified particles with a homogenizer, cool with stirring, and add at 40 ℃, and then to room temperature Stir with cooling to obtain a cosmetic cream.

Comparative Example 3. A cosmetic cream excluding divalent and trivalent iron salts is prepared by the same formulation and manufacturing method as in Example.

With respect to the creams of Examples and Comparative Examples, when the ionization reaction test with copper powder and nitric acid was carried out on the aqueous phase obtained by acidifying and separating the oil and fat components, the creams of Examples showed no coloration due to copper ions and divalent trivalent iron. It was confirmed that the cream had an ionic reaction inhibiting effect by salt.

As a result of a panel test conducted by 50 monitors, the cosmetic cream of the Example did not cause irritation even when it was applied to sensitive skin having inflammation such as atopic dermatitis, and the healing of the inflammatory site was promoted.

Example 4. Cosmetic oil Natural vitamin E oil 5.0% α-bisabolol 0.1% Olive oil to a total amount of 100.0%.

Preparation method and were added and dissolved, and then ^10-9 g of divalent and trivalent iron salt (neutral lipid carrier) /10.0% aqueous solution was added and shaken well to remove the separated aqueous phase. To dehydrate to obtain cosmetic oil.

Comparative Example 4. The same treatment as in Example 4 is used to prepare a cosmetic oil which is not subjected to shaking treatment with a divalent and trivalent iron salt.

In both Examples and Comparative Examples, the same amount of purified water was added, and the mixture was shaken well, and the separated aqueous phase was subjected to an ionization reaction test with copper powder and nitric acid. It was observed that the reaction was suppressed.

As a result of a panel test by 30 monitors, it was confirmed that xerosis and pruritus were alleviated, and that there was an effect of removing offensive odors and camphores and irritation caused by microorganisms in the thin part of the stratum corneum and the mucous membrane part.

Example 5. Cosmetic pack polyvinyl alcohol 15.0% glycerin 5.0% water-soluble polysiloxane copolymer 3.0% ethylene glycol monostearate 1.0% Fe ₂ Cl ₈ · XH ₂ O (neutral lipid carrier) 10 ^-12 (Fe ₃ As Cl ₈ ) Fragrance Suitable amount Add purified water to make the total amount 100.0%.

Add and to the manufacturing method to heat and dissolve it.
What was heated and melted was added and mixed evenly and cooled to 40 ° C.
The following is added, stirred, and cooled to room temperature to obtain a pack.

Comparative Example 5. A pack having the same formulation as in Example 5 but containing no divalent and trivalent iron salt is prepared.

When the 10% aqueous solutions of the packs of Example 5 and Comparative Example were subjected to an ionization reaction test with copper powder and nitric acid, it was confirmed that the Example had no coloration of copper ions and suppressed the ionic reaction.

According to the result of the panel test by 50 monitors, dry skin,
Improvement of oily skin was observed, and there was no irritation in the inflamed area and eczema area, and a healing reduction effect was observed.

Example 6. Shampoo Alkyl sulfate triethanolamine solution 20.0% Polyoxyethylene alkyl ether sodium sulfate solution 25.0% Coconut oil Fatty acid diethanolamide 5.0% Glycerin 10.0% Perfume Suitable amount Fe ₂ Cl ₅ · XH ₂ O (sodium chloride carrier) 10 ^-12 % (Fe ₂ Cl
₍₅ ) Add purified water to make the total amount 100.0%.

To is added sequentially to the manufacturing method and dissolved by heating to obtain shampoo.

Comparative Example 6. A shampoo having the same formulation as in Example 6 except for divalent and trivalent iron salts is prepared.

When an ionization reaction test with copper powder and nitric acid was carried out on both 10% aqueous solutions, it was confirmed that the examples did not show copper ion coloration and the ionic reaction was suppressed.

As a result of a continuous use test conducted by 50 monitors for 3 months, it was confirmed that the occurrence of dandruff and itchiness was clearly reduced with regular washing times.

Example 7. Hair tonic ethanol 65.0% Resorcin 0.1% Tolgaraci tincture 5.0% l-Menthol 0.5% Glycerin 5.0% Polyoxyethylene monostearate 2.0% Perfume Suitable amount Fe ₂ Cl ₅ · XH ₂ O (neutral lipid carrier) 10 ⁻¹² % (As Fe ₂ Cl ₅ ) Add purified water to make the total amount 100.0%.

To is sequentially added to the production method to dissolve by heating, and after cooling, it is filtered to obtain a hair tonic.

Comparative Example 7. A hair tonic having the same formulation as in Example 7 but containing no divalent and trivalent iron salt is prepared.

When an ionization reaction test with copper powder and nitric acid was carried out on both of them, it was confirmed that the ionic reaction was suppressed without seeing the coloration of copper ions in the examples.

In a long-term continuous use test for 6 months by 50 monitors
A clear reduction in hair loss, hair growth effect, and reduction of dandruff and itchiness were observed in 30 individuals.

Example 8. Foundation Titanium oxide 5.0% Mica 50.0% Talc 20.0% Aluminum stearate 5.0% Silica anhydride 5.0% Phytosterol 2.0% Polyoxyethylene monostearate 0.5% Silicone oil 7.0% Vaseline 3.5% Inorganic pigment Adequate amount Perfume Adequate amount Fe ₂ Cl ₅ · XH ₂ O (neutral lipid carrier) 10 ^-12 % (as Fe ₂ Cl ₅ ) Manufacturing method ~ and were mixed by heating and melted ~ and were mixed well, and this was pressed on a gold plate. And get the foundation.

Comparative Example 8. A foundation having the same formulation as in Example 8 but excluding the divalent and trivalent iron salts is prepared.

When an ionization reaction test with copper powder and nitric acid was performed on the aqueous phase portion obtained by extracting both with purified water, it was confirmed that the coloration of copper ions was not observed in the examples and the ionic reaction was suppressed.

As a result of a panel test conducted by 30 monitors with sensitive skin, it was found that the foundation of the example did not cause any skin irritation to all the monitors and the makeup retention was improved.

Example 9. Lipstick Carnauba wax 10.0% Candelilla wax 5.0% Cetanol 5.0% Phytosterol 10.0% Squalane 10.0% Pigment proper amount Perfume proper amount Castor oil is added to make a total amount of 100.0%.

Production method Castor oil was added with 10 ^-9 g of Fe ₂ Cl ₅ · XH ₂ O (neutral fat carrier) / aqueous solution (as Fe ₂ Cl ₅ ) and shaken to remove the separated aqueous phase, and anhydrous Glauber's salt Castor oil dehydrated by
Is added, and the mixture is heated and dissolved, poured into a mold, and cooled and solidified to obtain lipstick.

Comparative Example 9. A lipstick is prepared with the same formulation as in Example 9 using castor oil that is not treated with divalent and trivalent iron salts.

An ionization reaction test with copper powder and nitric acid was carried out on the aqueous phase portion obtained by heating and cooling both with the same amount of purified water, and in the examples, there was no coloration of copper ions and suppression of the ionic reaction was observed.

The results of a panel test conducted by 50 female monitors showed that the condition of the lip surface, which was non-irritating and tended to dry, was significantly improved.

Continuation of the front page (51) Int.Cl. ⁶ Identification code Reference number in the agency FI Technical display area A61K 7/075 A61K 7/075 33/26 ADA 33/26 ADA ADS ADS

Claims (1)

(57) [Claims] 1. A cosmetic product comprising a divalent and trivalent iron salt.