CN112076111B - Dandruff-removing shampoo composition - Google Patents

Abstract

The invention belongs to the field of daily chemicals, and relates to an anti-dandruff shampoo composition, a preparation method and application thereof. The invention provides an anti-dandruff shampoo composition, which comprises the following components: sodium PCA, niacinamide, potassium undecylenoyl hydrolyzed wheat protein. The invention also provides a preparation method of the scalp care composition and application of the scalp care composition in cosmetics. The composition provided by the invention selects a milder anti-dandruff agent of undecene to hydrolyze wheat protein potassium to inhibit malassezia, is matched with a powerful humectant of PCA sodium to prevent the scalp from drying, and is compounded with nicotinamide to repair the scalp barrier to restore the scalp to a healthy state, so that a better anti-dandruff effect is achieved.

Description

Dandruff-removing shampoo composition

Technical Field

The invention belongs to the field of daily chemicals, and particularly relates to an anti-dandruff shampoo composition

Background

With the deterioration of the environment and the increase of the working pressure of life, more and more people generate the dandruff problem, and the shampoo product with the dandruff removing function has great market value all the time. At present, a plurality of shampoos capable of cleaning hair and removing dandruff are available on the market, most of the shampoos contain various dandruff removing agents such as ZPT, OCT, chlorphenesin, climbazole, ketoconazole and the like, the performance of the dandruff removing shampoos depends on the action of the dandruff removing agents on malassezia, namely, so-called bactericides remained on the scalp in the hair washing process to ensure the dandruff removing effect, but the dandruff removing agents have certain irritation on the scalp, so that the malassezia easily generates drug resistance and also easily itch the head after long-term use, on the other hand, the barrier function of the scalp is damaged, dried, irritated, and the like, so that the scalp is easily abnormally dropped to generate dandruff, the microenvironment is also removed, the health condition of the scalp is ensured, and the problem of the dandruff of the scalp can be thoroughly changed.

Disclosure of Invention

In one aspect, the present invention provides a composition comprising the following ingredients: sodium PCA, niacinamide, undecylenoyl hydrolyzes potassium wheat protein.

In some embodiments, the composition comprises the following components in weight percent: 0.5-10% of PCA sodium, 0.5-5% of nicotinamide and 0.5-5% of potassium undecylenoyl hydrolyzed wheat protein.

In some embodiments, the composition comprises the following components in weight percent: 1-5% of PCA sodium, 1-3% of nicotinamide and 1-3% of potassium undecylenoyl hydrolyzed wheat protein.

In some embodiments, the composition further comprises a surfactant.

In some embodiments, the weight percent of the surfactant is 5-30%; preferably, the weight percentage of the surfactant is 10-25%.

In some embodiments, the surfactant is selected from one or more of ammonium lauryl sulfate, sodium lauryl sulfate, potassium lauryl sulfate, TEA lauryl sulfate, ammonium lauryl polyether sulfate, sodium lauryl polyether sulfate, TEA lauryl polyether sulfate, sodium lauroyl glutamate, disodium lauroyl glutamate, TEA lauroyl glutamate, sodium cocoamide glutamate, disodium cocoyl glutamate, TEA cocoyl glutamate, sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium myristoyl sarcosinate, sodium methylcocoyl taurate, sodium cocoyl methyl taurate, sodium lauroyl oat amino acid, sodium lauroyl wheat amino acid, sodium lauryl betaine, cocoyl betaine, myristyl betaine, lauryl hydroxysultaine, cocoyl hydroxysultaine, cocoamidopropyl betaine, myristamidopropyl betaine, sodium lauroyl amphoacetate, sodium cocoyl amphoacetate, sodium oleoyl amphoacetate, disodium lauroamphodiacetate, disodium cocoamphoglucoside, disodium lauryl glucoside, sodium myristyl lauryl glucoside, sodium cocoamphoacetate, sodium cocoyl acetate, and sodium cocoyl acetate.

In some embodiments, the surfactant is selected from sodium laureth sulfate and/or cocamidopropyl betaine.

In some embodiments, further comprising at least one of the following components: hair conditioner, pH regulator, thickener, antiseptic and essence.

In some embodiments, the hair conditioning agent is selected from one or more of polyquaternium-4, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-16, polyquaternium-22, polyquaternium-39, polyquaternium-47, polyquaternium-53, polyquaternium-67, polyquaternium-73, polyquaternium-74, guar hydroxypropyltrimonium chloride, hydroxypropyl guar hydroxypropyltrimonium chloride, acrylamidopropyltrimonium chloride/acrylamide copolymers, hydroxypropyl methylcellulose, cassia hydroxypropyltrimonium chloride, murumonium hydroxypropyltrimonium chloride, polydimethylsiloxane, dimethiconol, amodimethicone, PPG-3 octyl ether, C12-13 alcohol lactate, PEG-7 glyceryl cocoate, glyceryl laurate, PPG-14 butyl ether, di (PPG-2 myristyl polyether-10) adipate, caprylic/capric triglyceride.

In some embodiments, the hair conditioning agent is selected from polyquaternium-22.

In some embodiments, the pH adjusting agent is selected from one or more of citric acid, sodium citrate, sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, arginine.

In some embodiments, the pH adjusting agent is selected from citric acid.

In some embodiments, the thickener is selected from one or more of PEG-150 distearate, PEG-120 methyl glucose dioleate, hydroxypropyl methylcellulose, acrylic acid/C10-30 alkanol acrylate crosspolymer, acrylic acid copolymers, carbomers, cocamide methyl MEA, cocamide DEA, sodium chloride, ammonium chloride, sodium sulfate, zinc sulfate.

In some embodiments, the thickener is selected from cocamide methyl MEA.

In some embodiments, the preservative is selected from at least one of methylchloroisothiazolinone, methylisothiazolinone, DMDM hydantoin, bis (hydroxymethyl) imidazolidinyl urea, hexamidine di (isethionic acid) salt, potassium sorbate, chlorphenesin, phenoxyethanol, sodium benzoate, ethylhexylglycerin, methylparaben, 1, 2-hexanediol;

in some embodiments, the preservative is selected from sodium benzoate.

In some embodiments, the composition comprises the following components in weight percent:

a.0.5-10% sodium PCA

B.0.5% -5% of nicotinamide

C.0.5-5% Potassium undecylenoyl hydrolyzed wheat protein

D.5-30% of surfactant

E.0.1-10% of conditioner for hair

F.0-10% of thickening agent

G.0.01-1% preservative

H.0-2% essence

I.0-2% of pH regulator

J. The balance of water.

In some embodiments, the composition comprises the following components in weight percent:

a.1-5% sodium PCA

B.1-3% of nicotinamide

C.1-3% Potassium undecylenoyl hydrolyzed wheat protein

D.10-25% of surfactant

E.0.3-8% hair conditioner

F.0.5-5% of thickening agent

G.0.01-0.8% preservative

H.0-1% essence

I.0-1% of pH-adjusting agent

J. The balance of water.

In one aspect, the invention also provides the use of the composition in cosmetics;

preferably, the cosmetic is a personal cleansing product;

preferably, the cosmetic is a shampoo.

In one aspect, the invention also provides a preparation method of the composition, which comprises the following steps:

1) Adding a surfactant and water into an emulsifying pot at room temperature, and stirring and dispersing uniformly;

2) Adding the hair conditioner and the thickening agent into an emulsifying pot and uniformly stirring;

3) Sequentially adding nicotinamide, PCA sodium and potassium undecylenoyl hydrolyzed wheat protein into an emulsifying pot, and uniformly stirring;

4) Adding antiseptic, essence and pH regulator, and stirring.

According to the composition, a milder dandruff removing agent of undecene hydrolyzed wheat protein potassium is selected to inhibit malassezia, a powerful humectant of PCA sodium is matched to prevent the scalp from drying, and then nicotinamide is compounded to repair the scalp barrier to enable the scalp to recover the healthy state, so that a better dandruff removing effect is achieved.

Drawings

FIG. 1 is the results of in vitro dandruff removal testing of different groups;

FIG. 2 shows the results of the moisture retention test for sodium PCA;

fig. 3 is a niacinamide scalp repair test result;

fig. 4 is the results of clinical tests of the overall anti-dandruff moisturizing scalp repair performance.

Detailed Description

The technical solutions of the present application are further illustrated by the following specific examples, which do not represent a limitation to the scope of the present application. Insubstantial modifications and adaptations of the disclosed concepts by others based on the teachings of the present disclosure are intended to be covered by the present disclosure.

Examples 1-9 an antidandruff shampoo composition (in weight percent)

TABLE 1

The preparation method comprises the following steps:

1. stirring and mixing sodium laureth sulfate, cocamidopropyl betaine and pure water in an emulsifying pot uniformly at room temperature;

2. adding polyquaternium-22 and cocoamide methyl MEA, and stirring and mixing uniformly;

3. adding PCA sodium, nicotinamide and undecenoyl hydrolyzed wheat protein potassium, stirring and mixing uniformly;

4. adding sodium benzoate, citric acid and essence, stirring, and mixing.

Comparative example

The preparation method of each example is the same as that of examples 1 to 9.

And (3) performance testing:

in summary, the combinations of examples 1-9, comparative example 1 and comparative example 2 were tested for performance, including in vitro anti-dandruff performance, moisturizing performance, and anti-dandruff performance on clinical trials.

In vitro dandruff removal performance test:

the inhibition effect of the shampoo on malassezia furfur is tested by adopting a bacteriostatic ring method, and the bacteriostatic ring test for evaluating the anti-dandruff effect of each group of anti-dandruff shampoos is carried out under the same test conditions:

experimental Material

1. The main apparatus is as follows: a constant temperature incubator, an ultra-clean workbench, a puncher, a liquid transferring gun, a small forceps and a sterilization flat plate.

2. Culture medium: leeming & Notman medium was modified.

3. Strain: malassezia furfur.

4. Test samples: the anti-dandruff shampoo compositions of example 7, example 2, example 8, example 9, and comparative example 3 and comparative example 6.

Contents of the experiment

1. Malassezia furfur is prepared into 10 ⁵ Bacterial suspension around cfu.

2. Evenly spread on a Leeming & Notman culture medium plate, and then placed in a sterile operating platform to blow dry the bacterial liquid on the plate.

3. Quantitatively adding each shampoo composition sample into the flat plate, culturing in a 30 ℃ constant temperature incubator for 5-7 days, observing the result, and recording and measuring the bacteriostatic ring condition.

Results of the experiment

The results are reported as the diameter of the zone of inhibition, in units: and (4) millimeter.

Wherein, fig. 1 is a graph of the inhibition effect of the shampoo on malassezia furfur, as can be seen from fig. 1, the inhibition effect is not ideal in comparative example 3 (containing no undecylenoyl hydrolyzed wheat protein potassium) and comparative example 6 (containing 0.3% of lower undecenoyl hydrolyzed wheat protein potassium), example 7 (0.5% of undecenoyl hydrolyzed wheat protein potassium) already has good inhibition effect on the dandruff microorganism malassezia furfur, the better inhibition effect is also obtained with the increase of the dosage, but the effect is slowly increased after the dosage exceeds 2%. Cost is too high to be economically effective beyond 5%.

And (4) moisture retention performance test:

sodium pca moisture retention test: the test subjects washed their hair with 40 ℃ water using the shampoo of examples and comparative examples, dried by blowing after washing, and measured the water content of the horny layer of the scalp for 0 hour, measured the water content of the horny layer of the scalp again for 4 hours in a constant temperature and humidity room, and measured the water content of the horny layer of the scalp again for 8 hours in a constant temperature and humidity room.

Skin moisture content test probes (instrument software CK-MPA-Multi-Probe-AdapterFB) were used: corneometer CM825 tests scalp stratum corneum moisture. Fig. 2 is a graph of the moisture content of the scalp stratum corneum (where n =12 indicates the number of persons tested and the sample amount, and the data is averaged), and it can be seen from fig. 2 that comparative example 1 with no sodium PCA added has the lowest moisture content of the scalp stratum corneum, and then comparative example 4 with 0.2% sodium PCA, whereas the moisturizing effect of the shampoo starts to be greatly improved after the amount of sodium PCA used is more than 0.5% (example 1), and the moisturizing effect is limited after the amount of sodium PCA used is more than 2% (examples 2, 3, and 4). In view of the moisturizing effect and the economical efficiency of cost, the addition amount of PCA is preferably 0.5 to 10%. In addition, the scalp stratum corneum moisture content of comparative example 1 to which no sodium PCA was added was not much different after 0h,4h, and 8h, whereas the scalp stratum corneum moisture content increased with time after the addition of sodium PCA, indicating that sodium PCA also had a long-lasting moisturizing effect.

2. Niacinamide scalp repair test: the testers rated the chamber every monday, wednesday, friday, washed the hair with 40 ℃ water using the shampoos of example 2, example 5, example 6 and comparative example 2, comparative example 5, dried after washing, and measured the moisture content of the horny layer of the scalp on days 0, 7, 14, 21 and 28.

Skin moisture content test probes (instrument software CK-MPA-Multi-Probe-AdapterFB) were used: corneometer CM825 tests scalp stratum corneum moisture. As can be seen from fig. 3, niacinamide can increase the moisture content of the scalp stratum corneum in time by a small amount, and the moisturizing effect increases with the increase of the amount. The more significant the increase in stratum corneum moisture content with increasing trial time (e.g., day 28 data) indicates that the scalp stratum corneum moisturizes better, especially with increasing amounts of niacinamide from 0.5% to 2% (example 5 to example 2), with a slower increase of 2% above.

Clinical test of the overall dandruff removing and moisturizing scalp repairing performance:

the shampoo of example 2 and comparative example 1, comparative example 2 and comparative example 3 and the multi-effect maintenance type shampoo for clearing men scurf are distributed into 60 to 200mL test packaging bottles for comparison and sent to test groups (60 people). Each shampoo was used for 4 weeks continuously and the panelists scored the questionnaire test items according to the use feeling. The scoring criteria used were 7 points, 1 being the worst, 7 being the best, the higher the score the better. The final score is shown as the average score after statistics in fig. 4.

FIG. 4 shows that the compositions have synergistic effects, and that sodium PCA, in addition to increasing moisturization, indirectly increases the anti-dandruff and anti-itch and scalp health benefits (comparative example 1 and example 2); the addition of niacinamide is effective in repairing scalp (comparative example 2 and example 2), and the scurf and itching condition after scalp repair and healthier scalp is also improved; the addition of potassium undecylenoyl hydrolyzed wheat protein was significantly improved in anti-dandruff effect (comparative example 3 and example 2) and also had positive effect on scalp care since it was a protein itself. Finally, compared with the multi-effect maintenance type of the commercial anti-dandruff shampoo for cleaning men, the composition disclosed by the invention is higher in evaluation in each investigation dimension.

In view of the many possible embodiments to which the principles of the disclosed invention may be applied, it should be recognized that the illustrated embodiments are only preferred examples of the application and should not be taken as limiting the scope of the application. Rather, the scope of the application is defined by the appended claims. We therefore claim as our invention all those inventions that come within the scope and spirit of these claims.

Claims (16)

1. The composition is characterized by comprising the following components in percentage by weight:

A.0.5-10% PCA sodium

B.0.5% -5% of nicotinamide

C.0.5-5% of potassium undecylenoyl hydrolyzed wheat protein

D.5-30% of surfactant

E.0.1-10% of hair conditioner

F.0-10% of thickening agent

G.0.01-1% of preservative

H.0-2% of essence

I.0-2% of pH regulator

J. The balance being water.

2. The composition of claim 1, wherein the composition comprises the following components in weight percent:

A.1-5% PCA sodium

B.1-3% of nicotinamide

C.1-3% Potassium undecylenoyl hydrolyzed wheat protein

D.10-25% of surfactant

E.0.3-8% of hair conditioner

F.0.5-5% of thickening agent

G.0.01-0.8% of preservative

H.0-1% of essence

I.0-1% of pH adjusting agent

J. The balance being water.

3. A composition according to any one of claims 1 to 2, wherein the surfactant is selected from the group consisting of ammonium lauryl sulfate, sodium lauryl sulfate, potassium lauryl sulfate, TEA lauryl sulfate, ammonium lauryl polyether sulfate, sodium lauryl polyether sulfate, TEA lauryl polyether sulfate, sodium lauryl glutamate, disodium lauryl glutamate, TEA lauryl glutamate, sodium cocoamidoglutamate, disodium cocoyl glutamate, TEA cocoyl glutamate, sodium lauryl sarcosinate, sodium cocoyl sarcosinate, sodium myristyl sarcosinate, sodium cocoyl taurate, sodium lauroyl avenamido, sodium lauroyl wheatamino acid, sodium lauryl betaine, cocoyl betaine, myristyl betaine, lauryl hydroxysultaine, cocoamidopropyl betaine, myristyl propyl betaine, sodium lauroyl amphoacetate, sodium cocoyl ampho, glucoside, disodium lauroyl diacetic acid, disodium cocoyl amphoacetate, sodium cocoyl diacetic acid, sodium cocoyl diacetate, sodium cocoyl acetate, sodium lauryl acetate, sodium cocoyl decyl acetate, and sodium cocoyl acetate.

4. The composition of any one of claims 1-2, wherein the surfactant is selected from the group consisting of sodium laureth sulfate and cocamidopropyl betaine.

5. The composition according to any one of claims 1-2, wherein the hair conditioning agent is selected from one or more of polyquaternium-4, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-16, polyquaternium-22, polyquaternium-39, polyquaternium-47, polyquaternium-53, polyquaternium-67, polyquaternium-73, polyquaternium-74, guar hydroxypropyltrimonium chloride, hydroxypropylguar hydroxypropyltrimonium chloride, acrylamidopropyltrimonium chloride/acrylamide copolymers, hydroxypropyl methylcellulose, cassia hydroxypropyltrimonium chloride, buryam hydroxypropyltrimonium chloride, polydimethylsiloxane, dimethiconol, amodimethicone, PPG-3 octyl ether, C12-13 alcohol lactate, PEG-7 glyceryl cocoate, glyceryl laurate, PPG-14 butyl ether, bis (PPG-2 myristyl polyether-10) adipate, caprylic/capric triglyceride.

6. The composition of any of claims 1-2, wherein the hair conditioning agent is selected from polyquaternium-22.

7. The composition according to any one of claims 1-2, wherein the pH adjusting agent is selected from one or more of citric acid, sodium citrate, sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, arginine.

8. The composition of any one of claims 1-2, wherein the pH adjusting agent is selected from citric acid.

9. The composition according to any one of claims 1-2, wherein the thickener is selected from one or more of PEG-150 distearate, PEG-120 methyl glucose dioleate, hydroxypropyl methylcellulose, acrylates/C10-30 alkanol acrylate crosspolymer, acrylates copolymer, carbomer, cocamide methyl MEA, cocamide DEA, sodium chloride, ammonium chloride, sodium sulfate, zinc sulfate.

10. The composition according to any one of claims 1-2, wherein the thickener is selected from the group consisting of cocamide methyl MEA.

11. The composition of any of claims 1-2, wherein the preservative is selected from at least one of methylchloroisothiazolinone, methylisothiazolinone, DMDM hydantoin, bis (hydroxymethyl) imidazolidinyl urea, hexamidine bis (isethionic acid) salt, potassium sorbate, chlorphenesin, phenoxyethanol, sodium benzoate, ethylhexyl glycerol, methylparaben, 1, 2-hexanediol.

12. The composition of any one of claims 1-2, wherein the preservative is selected from sodium benzoate.

13. Use of a composition according to any of claims 1-2 in cosmetics.

14. The use of claim 13, wherein the cosmetic product is a personal cleansing product.

15. Use according to claim 13, wherein the cosmetic product is a shampoo.

16. A process for preparing a composition as claimed in any one of claims 1 to 2, comprising the steps of:

1) Adding a surfactant and water into an emulsifying pot at room temperature, and stirring and dispersing uniformly;

2) Adding the hair conditioner and the thickening agent into an emulsifying pot and uniformly stirring;

3) Sequentially adding nicotinamide, PCA sodium and potassium undecylenoyl hydrolyzed wheat protein into an emulsifying pot, and uniformly stirring;

4) Adding antiseptic, essence and pH regulator, and stirring.

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