KR100820343B1 - Compositions for treating inflammatory dermatological disease - Google Patents

Abstract

A composition comprising an extract of Petasites japonicus is provided to be effective for treating inflammatory skin diseases such as allergic dermatitis, bite wound and dermatophytosis. A composition for treating inflammatory skin diseases comprises a hot water extract, an ethanol extract, an osmotic pressure extract, or a compression juice of Petasites japonicus. The composition further comprises at least one ingredient selected from the group consisting of a nano-silver particles having a size of less than 500 nanometers, phenol. dl-camphor, and salicylic acid. A topically administering formulation comprises the composition and is ointment, cream, lotion, gel, liquid, soap or toothpaste.

Description

Compositions for treating inflammatory dermatological diseases

The present invention relates to a composition for treating inflammatory skin diseases, and more particularly, to a composition for treating inflammatory skin diseases comprising a herbal extract.

Inflammatory skin disease refers to a skin disease accompanied by an inflammatory response such as itching (pruritus), edema, erythema, peeling, etc. due to various stimulating factors causing a series of inflammatory reactions in the skin epithelium.

Such inflammatory skin diseases include allergic dermatitis caused by various causes, bites caused by animals or insects, skin fungus, acne and the like. Among them, allergic dermatitis collectively refers to dermatitis caused by various allergens, including atopic dermatitis, contact dermatitis, urticaria, food allergy, and drug allergy. Among allergic dermatitis, atopic dermatitis is a serious problem due to the recent increase in the westernization of the diet, housing environment, increased stress, and contaminants due to industrial development.

Atopic dermatitis is an itchy, eczema-like skin disease that occurs in people with atopic dermatitis. Atopic dermatitis, a type of allergic dermatitis, corresponds to 80-90% of pediatric eczema, and has recently occurred in adults.

Treatment of inflammatory skin diseases, including atopic dermatitis, includes antihistamines, corticosteroids for the skin, or optical therapy that orally irradiates with ultraviolet light after the administration of psoralen, but this is only effective for some patients. It does not work well for patients. In addition, corticosteroids, etc. are accompanied by various side effects when used for a long time, and optical therapy also has a side effect of increasing the risk of skin cancer.

Recently, Korean Patent Publication No. 2004-97026, raw pine needles, elm bark, raw cucumber, raw indongcho, fresh mulberry leaves, bamboo dew, fresh pine, fresh mugwort, fresh seaweed, raw chestnut, licorice, fresh garlic, green tea leaf, kelp A mixture of extracts (物 出 物) is a liquid or solid composition for preventing atopic dermatitis, characterized in that the composition for preventing and treating atopic dermatitis is disclosed, and the development of a therapeutic agent for atopic skin diseases. However, atopic dermatitis is still difficult to treat, and continuous research and development of the treatment is required.

Meanwhile, Butterbur ( Petasites) japonicus ) is a perennial shrub that grows not only in Europe, but also in Asia and North America. Extracts from roots, leaves, and stems have been used as therapeutic agents for over 2000 years. Butterbur extract has been reported to be used for muscle relaxation, abdominal pain treatment, smooth muscle spasm stabilizing effect, pain relief effect and also for headache (Eaton J. Townsend Lett, 2000, 202, 104-106). In addition, Korean Patent Laid-Open Publication No. 2003-0016137 discloses that the coltsfoot extract has sulfated activity and is effective as a preventive or therapeutic agent for brain diseases due to neuronal cell protective effects, and Korean Patent Laid-Open 2005-0001419 discloses It is disclosed that there is a protective function of the brain function and memory enhancement effect. However, it is not known whether butterbur extract is effective in treating inflammatory skin diseases such as atopic dermatitis.

Accordingly, the present inventors studied a method for effectively treating inflammatory skin diseases including atopic dermatitis, and found that butterbur extract has an excellent effect in treating various inflammatory skin diseases including atopic dermatitis. It became.

Accordingly, it is an object of the present invention to provide a composition for treating inflammatory skin diseases comprising coltsfoot extract.

In order to achieve the above object, the present invention provides a composition for the treatment of inflammatory skin disease, including Butterbur ( Petitesites japonicus ) extract.

The present invention also provides a formulation for topical administration in which a composition comprising the coltsfoot extract is formulated.

Hereinafter, the present invention will be described in more detail.

Inflammatory skin disease treatment composition according to the invention is characterized in that it comprises butterbur extract as an active ingredient.

Extract of coltsfoot extract contained in the composition for treating inflammatory skin diseases according to the present invention can be obtained by a conventional extraction method known in the art, typically as a hydrothermal extract, alcohol extract, osmotic extract, or compressed juice Can lose.

That is, the butterbur extract according to the present invention may be prepared by cutting or crushing the raw butterbur into a predetermined size, and then extracting, filtering, and concentrating with an extraction solvent. As the extraction solvent, various solvents including alcohols such as water, methanol and ethanol may be used, and an saccharide, sodium, or potassium may be added directly, or an aqueous solution containing saccharides, sodium, or potassium may be used. Preferably, water or ethanol may be used as an extraction solvent for preparing the mixed extract of the present invention. Butterbur extract according to the present invention can also be used as it is extracted raw juice by pressing the raw butterbur as it is.

When explaining the method of producing a hot water extract, alcohol extract, osmotic extract, and compressed juice of butterbur according to the present invention in more detail.

The hydrothermal extract of coltsfoot washes and shreds raw, undried colts; Placing the crushed coltsfoot with water into a pressure vessel and treating at high temperature and high pressure; And it can be obtained by a method comprising the step of concentrating the extracted liquid with a vacuum concentrator. In addition, the alcohol extract of butterbur is washed and shredded raw butterbur; Adding alcohol such as methanol or ethanol to the crushed butterbur, followed by primary extraction with stirring at a temperature of 50-90 ° C. for several hours, and then re-extracting by adding alcohol again; And it can be obtained by a method comprising the step of concentrating the extracted liquid with a vacuum concentrator. Pressed juice of butterbur is washed and crushed clean raw butterbur; And it can be obtained by a method comprising the step of obtaining a fresh juice by pressing in a pressure juicer.

Osmotic extraction of butterburs includes washing and crushing the raw uncooked butterburs; And using sugars, sodium, or potassium as a single substance to adjust the osmotic pressure concentration, or blending them in an appropriate blending ratio, or dissolving it in water, mixing it with crushed coltsfoot and raw coltsfoot or dry colts for a predetermined time. You can get it.

Such butterbur extract may be used as raw juice or concentrated hydrothermal extract, alcohol extract, or osmotic extract, but such extract may be lyophilized to prepare a powder form and then used.

The coltsfoot used to prepare the coltsfoot extract can be used both in nature or artificially cultivated, and all parts such as roots, stems, leaves, flowers of coltsfoot, preferably an outpost can be used.

The composition for treating inflammatory skin diseases according to the present invention may further include one or more of any known drug that can increase the therapeutic effect of inflammatory skin diseases in addition to coltsfoot extract. Drugs that may be added to the composition for treating inflammatory skin diseases according to the present invention include silver nanoparticles, phenol, DL-campa, or salicylic acid, which are typically antimicrobial agents. Silver nanoparticles should have a size of 500 nanometers or less with antibacterial properties. Drugs that may be additionally included in the composition for treating inflammatory skin diseases according to the present invention may be included in an appropriate content range depending on the drug used, for example, Diel-Kampa is 0.1 to 10 parts by weight based on 100 parts by weight of butterbur , Phenol may be included in the range of 0.1 to 10 parts by weight, salicylic acid is 0.5 to 30 parts by weight, silver nanoparticles may be contained in a concentration of 5 to 10000 ppm.

The composition comprising coltsfoot extract according to the present invention can be used for the treatment of various inflammatory skin diseases. Inflammatory skin diseases that the composition of the present invention can treat include, but are not limited to, allergic dermatitis, bite, acne, or skin fungus. A bite is a skin wound caused by insects such as mosquitoes, bees, ants, or beasts such as snakes. Cutaneous fungal disease refers to skin diseases caused by fungi (fungus), and includes all of the ringworm, which is formed by the fungus in the human body, athlete's foot, and the like.

Allergic dermatitis that the composition of the present invention can treat includes atopic dermatitis, contact dermatitis, urticaria, food allergy, or drug allergy. The composition of the present invention has an excellent effect on the relief of itching among the symptoms of inflammatory skin diseases, and can be effectively used to treat atopic dermatitis, especially among the inflammatory skin diseases.

The composition for treating inflammation comprising the extract of coltsfoot according to the present invention may be formulated as a formulation for topical administration. As an agent for topical administration, the composition for treating inflammation according to the present invention may be formulated in the form of an ointment, cream, lotion, gel, or liquid. Such topical formulations may be prepared by conventional methods known to those of skill in the art, and typically, methods for preparing such topical formulations are formulated in Remington's Pharmaceutical Science, 15 ^th , which is well known in the pharmaceutical arts. Edition, 1975, Mack Publishing Company, Easton, Pennsylvania 18042, Chapter 87: Blaug, Seymour. Such topical preparations may be prepared by further comprising one or more pharmaceutically acceptable excipients, excipients, diluents, and the like, in addition to the composition of coltsfoot extract, wherein 'acceptable' means allergic or toxic reactions when administered to humans. Say something that does not cause. Briefly, when formulated into an ointment, cream, lotion, or gel, it can be prepared by adding butterbur extract to an ointment base, cream base, lotion base, or gel base, respectively.

Butterbur extract included in the topical preparations according to the present invention may vary in content required to achieve the desired effect depending on the preparation and concentration of the extract. For example, when using the raw juice obtained by compressing the raw butterbur can be used in 0.05 to 70.0% by weight, preferably from 0.05 to 50% by weight based on the whole topical formulation. If the butterbur extract does not reach the above range, the desired effect is not sufficient, and if it exceeds the above range, there is no increase of the effect due to the increase in content is uneconomical.

In addition, the composition for treating inflammatory skin diseases according to the present invention may be formulated in the form of soap, face wash, or toothpaste. Formulations of soaps, face washes, and toothpastes can be prepared by the addition of butterbur extract to methods of preparation already well known in the art. The amount of coltsfoot extract contained in such soaps, face washes, or toothpastes varies depending on the preparation or concentration of the extract as described above, but when using raw juice obtained by compressing the raw coltsfoot, 0.05% of the whole soap, face wash, or toothpaste is used. To 30% by weight, preferably from 0.05 to 5% by weight.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, this is for illustrating the present invention, and the present invention is not limited by these examples.

<Example>

Example 1: Preparation of Butterbur Extract

1.5 kg of butterburs were placed in a pressurized juicer (based on product name and / or company name) and juiced to obtain 700 g of butterbur compressed juice.

Examples 2 to 6: Preparation of Mixture of Butterbur Extract and Other Inflammatory Skin Disease Therapeutics

As shown in Table 1, to 100 g of butterbur compressed juice obtained in Example 1 was prepared a mixture further comprising the following inflammatory skin disease therapeutics.

Example 7: Preparation of a formulation comprising coltsfoot extract according to the present invention

7-1. Manufacture of ointments

50 g of petrolatum was added to 50 g of the butterbur extract or mixture of Examples 1 to 6, followed by stirring with a stirrer to prepare the ointments of Examples 1 to 6, respectively.

7-2. Manufacture of cream

40 g of a cream base containing 1.5 g of stearic acid, 2.2 g of stearyl alcohol, 0.5 g of butyl stearate, 0.5 g of propylene glycol, 2.0 g of monostearate, glycerin 2.0 g, 0.3 g of potassium hydroxide, an aqueous component, an aqueous component, a surfactant, etc. 2 g of the compressed juice prepared in Example 1 were mixed to emulsify well in a mixer, degassed, filtered, and cooled to prepare a cream composition.

7-3. Preparation of face wash

6 g of glycerine, 2.0 g of monoalkyl phosphate, 0.5 g of sodium hydroxide solution, 1.5 g of myristic acid, and 12 g of a cleanser base containing a trace amount of a mixed solution of 1 g of the pressed juice prepared in Example 1 were mixed with a homo mixer. After stirring in a mixer) was heated for 3 minutes at 60 ℃ and then degassed and cooled to 37 ℃ to prepare a face wash composition.

7-4. Manufacture of soap

Soap was prepared by mixing 99.5% by weight of the soap base (including water) and 0.5% by weight of the compressed juice prepared in Example 1 with a mixer, followed by extrusion and cutting in a soap maker.

Experimental Example 1: Inflammatory skin disease treatment experiment (1)

It was tested whether the composition prepared in Example 1 is effective in treating inflammatory skin disease.

For the test, the composition prepared in Example 1 was administered to 100 patients (50 males, 50 females) in atopic dermatitis patients, contact dermatitis patients, mosquito bite patients, and athlete's foot athletes in 25 patients each. Was applied twice a day and the effect was observed. Treatment effects were classified as worsening, no effect, somewhat effective, effective, and very effective according to the symptom of improvement of the patient. The results are shown in Table 2 below.

Experimental Example 2: Inflammatory Skin Disease Treatment Experiment (2)

The compositions prepared in Examples 1 to 6 were tested for their effectiveness in treating inflammatory skin diseases.

The ointment of the composition prepared in Examples 1 to 6 or the composition of Examples 1 to 6 prepared in Examples 7-1 was applied to a person having atopic disease, ringworm, bite, or athlete's foot on various body parts. It was applied twice a day in the evening and the course of the skin disease was recorded. The results are shown in Table 3 below.

As described above, the composition comprising coltsfoot extract according to the present invention is effective in treating inflammatory skin diseases such as allergic dermatitis, bite or skin mycosis, and is particularly effective in treating atopic dermatitis, which has recently increased rapidly. It can be seen that.

Claims (7)

A composition for treating skin fungal disease comprising colostrum hydrothermal extract, ethanol extract, osmotic extract, or compressed juice. delete The composition of claim 1, further comprising at least one component selected from the group consisting of up to 500 nanometers of silver nanoparticles, phenol, DL-campa, and salicylic acid. delete delete A formulation for topical administration comprising a composition according to claim 1. 7. The formulation according to claim 6, wherein the formulation for topical administration is an ointment, cream, lotion, gel, liquid, soap, or toothpaste.