CN111714421A

CN111714421A - Fullerene maintenance antibacterial gel and preparation method thereof

Info

Publication number: CN111714421A
Application number: CN202010690567.1A
Authority: CN
Inventors: 王竹; 韩莎; 房心民
Original assignee: Xi'an Beidisike Biotechnology Co ltd
Current assignee: Xi'an Beidisike Biotechnology Co ltd
Priority date: 2020-07-17
Filing date: 2020-07-17
Publication date: 2020-09-29
Anticipated expiration: 2040-07-17
Also published as: CN111714421B

Abstract

The invention discloses a fullerene maintenance antibacterial gel and a preparation method thereof, wherein the fullerene maintenance antibacterial gel is prepared from the following raw materials in parts by mass: 0.2-1.0 part of fullerene C60, 0.1-1.0 part of gene recombinant human collagen, 0.1-12 parts of humectant, 1-6 parts of plant extract, 0.2-3 parts of thickener, 0.1-0.8 part of PH regulator, 0.1-3 parts of anti-inflammatory agent, 0.01-0.8 part of bacteriostatic agent and 72.4-98.19 parts of purified water.

Description

Fullerene maintenance antibacterial gel and preparation method thereof

Technical Field

The invention belongs to the technical field of gynecological product nursing, and particularly relates to a fullerene maintenance antibacterial gel and a preparation method thereof.

Background

Along with the improvement of living standard of people, the health protection consciousness of people is gradually strengthened, and more people begin to pay attention to personal health and protection, especially the private maintenance of women. Women begin to age more than 20 years, and with the age, the body of the women ages, the fat in private parts begins to decrease, and gradually becomes loose and aged with the age. When women approach the menopause, their intravaginal membranes begin to thin, blood flow decreases, and pelvic floor muscles weaken. The loose pudendum can affect the female sexual confidence, and the skin of the pudendum can be excessively stretched by unreasonable movement, which causes injury.

With age, parts of the body are constantly exposed to oxygen, particularly organs affected by oxygen including reactive oxygen species, lipid peroxides, and the like. The theory of free radicals considers that free radicals are an important factor affecting human aging. Endogenous oxygen free radicals are produced during the metabolism of the body, and the free radicals produced by the metabolism are the main sources of free radicals in the human body. The excessive free radical aggregation of human body can cause body damage, the damage accumulation exceeds the repair capability of the body, various macromolecular damages of skin can be caused, the cell differentiation state is changed and even lost, therefore, the aging of the body part is accelerated, and the free radical is an important factor for causing skin damage and aging in the aging process of the body part.

The existing private products generally have the bacteriostatic function, do not have the function of scavenging free radicals, and have single efficacy and poor bacteriostatic effect.

Disclosure of Invention

The invention aims to overcome the defects of the prior art, provides the fullerene maintenance antibacterial gel and the preparation method thereof, and effectively overcomes the defects that the existing private products generally have an antibacterial function and no function of scavenging free radicals, and the products have single efficacy and poor antibacterial effect.

In order to solve the technical problem, the technical scheme of the invention is as follows: a fullerene maintenance antibacterial gel is composed of the following raw materials in parts by mass: 0.2-1.0 part of fullerene C60, 0.1-1.0 part of gene recombinant human collagen, 0.1-12 parts of humectant, 1-6 parts of plant extract, 0.2-3 parts of thickener, 0.1-0.8 part of PH regulator, 0.1-3 parts of anti-inflammatory agent, 0.01-0.8 part of bacteriostatic agent and 72.4-98.19 parts of purified water.

Preferably, the raw materials in parts by weight are as follows: 0.2-0.8 part of fullerene C60, 0.1-0.8 part of gene recombinant human collagen, 0.1-10 parts of humectant, 2-5 parts of plant extract, 0.5-2 parts of thickener, 0.1-0.5 part of PH regulator, 0.1-2 parts of anti-inflammatory agent, 0.01-0.5 part of bacteriostatic agent and 78.4-96.89 parts of purified water.

Preferably, the raw materials in parts by weight are as follows: 0.5 part of fullerene C60, 0.5 part of gene recombinant human collagen, 2.5 parts of humectant, 4 parts of plant extract, 1 part of thickening agent, 0.3 part of PH regulator, 1 part of anti-inflammatory agent, 0.04 part of bacteriostatic agent and 90.16 parts of purified water.

Preferably, the humectant is selected from one or more of sodium hyaluronate, glycerin, butanediol, beta glucan and betaine; the plant extract is one or more selected from cacumen Platycladi extract, Hamamelis virginiana extract, cortex Phellodendri extract, and herba Portulacae extract; the thickening agent is one or more of sodium carboxymethylcellulose, hydroxyethyl cellulose, xanthan gum, pectin, guar gum, gellan gum, carrageenan and starch;

preferably, the pH regulator is selected from one or more of citric acid, lactic acid and malic acid; the anti-inflammatory agent is one or more selected from dipotassium glycyrrhizinate, allantoin and PCA-Zn; the bacteriostatic agent is selected from one or more of chlorhexidine gluconate, benzalkonium chloride, domiphen bromide and triclosan.

Preferably, the mass ratio of the fullerene C60 to the gene recombinant human collagen is 1: 1.

preferably, the preparation method of the fullerene maintaining and inhibiting gel comprises the following steps:

step 1) uniformly dispersing 0.2-3 parts of thickening agent in 0.1-12 parts of humectant;

step 2) adding the dispersed solution obtained in the step 1) into 72.4-98.19 parts of purified water at 60 ℃, and stirring in a constant-temperature water bath until the solution is completely dissolved;

step 3) cooling to below 40 ℃, adding 0.2-1.0 part of fullerene C60, 0.1-1.0 part of gene recombinant human collagen, 1-6 parts of plant extract, 0.1-3 parts of anti-inflammatory agent, 0.01-0.8 part of bacteriostatic agent and 0.1-0.8 part of pH regulator, homogenizing for half an hour, and vacuumizing to obtain fullerene maintenance bacteriostatic gel;

and 4) filling the fullerene curing antibacterial gel prepared in the step 3) by using a full-automatic gel filling machine.

Compared with the prior art, the invention has the advantages that:

(1) the antibacterial gel is prepared by compounding fullerene C60, gene recombinant human collagen, a humectant, a plant extract, a thickening agent, a pH regulator, an anti-inflammatory agent, a bacteriostatic agent and purified water according to the mass ratio of 1:1, wherein the fullerene C60 and the gene recombinant human collagen can resist free radicals of organisms, activate cells and play an external protection effect, and the gene recombinant human collagen has excellent biocompatibility, can adjust the synthesis of human collagen and plays an internal maintenance effect; the Hamamelis virginiana extract selected by the invention has the effects of anti-inflammation and convergence, the phellodendron extract and the cacumen biotae extract have excellent antibacterial and antiviral effects, and the purslane extract has the effects of anti-allergy and anti-inflammation, and meanwhile, the antibacterial preparation adopted by the invention is safe and non-irritant, and the antibacterial capacity and the free radical removing function of fullerene curing antibacterial gel are improved through the synergistic interaction among the components, so that the product has multiple effects;

(2) the fullerene C60 used in the invention is the minimum molecule reaching a stable structure in a fullerene spherical structure, so that the fullerene C60 has relatively small molecular weight and is easy to be absorbed by skin while having stable property, can be compatible with free radicals generated by organisms, has high-efficiency oxidation resistance, can play a role in activating cells and preventing skin from fading, and can remarkably enhance the skin elasticity and tighten the skin after being used for a long time by adding the fullerene C60 into a system;

(3) the gene recombinant human collagen selected by the invention is type III collagen, is collagen with very rich content in fibrous collagen, has complete affinity and excellent biocompatibility with human source fragments, is more beneficial to skin absorption, can increase fibroblasts after long-term use, regulates the collagen synthesis of a human body, and promotes the skin elasticity to increase.

Detailed Description

The following describes embodiments of the present invention with reference to examples:

it should be noted that the structures, proportions, sizes, and other elements shown in the specification are included for the purpose of understanding and reading only, and are not intended to limit the scope of the invention, which is defined by the claims, and any modifications of the structures, changes in the proportions and adjustments of the sizes, without affecting the efficacy and attainment of the same.

In addition, the terms "upper", "lower", "left", "right", "middle" and "one" used in the present specification are for clarity of description, and are not intended to limit the scope of the present invention, and the relative relationship between the terms and the terms is not to be construed as a scope of the present invention.

The invention discloses a fullerene maintenance antibacterial gel which is prepared from the following raw materials in parts by weight: 0.2-1.0 part of fullerene C60, 0.1-1.0 part of gene recombinant human collagen, 0.1-12 parts of humectant, 1-6 parts of plant extract, 0.2-3 parts of thickener, 0.1-0.8 part of PH regulator, 0.1-3 parts of anti-inflammatory agent, 0.01-0.8 part of bacteriostatic agent and 72.4-98.19 parts of purified water.

Preferably, the raw materials in parts by weight are as follows: 0.5 part of fullerene C60, 0.5 part of gene recombinant human collagen, 2.5 parts of humectant, 4 parts of plant extract, 1 part of thickener, 0.3 part of PH regulator, 1 part of anti-inflammatory agent, 0.04 part of bacteriostatic agent and 90.16 parts of purified water.

The fullerene C60, the gene recombinant human collagen, the plant extract, the humectant, the thickener, the pH regulator, the anti-inflammatory agent and the bacteriostatic agent are all commercially available products.

Example 1

A fullerene maintenance antibacterial gel is composed of the following raw materials in parts by mass: the anti-inflammatory and antibacterial agent comprises, by weight, 600.4 parts of fullerene C, 0.5 part of gene recombinant human collagen, 1 part of a humectant, 3 parts of a plant extract, 1 part of a thickening agent, 0.3 part of a pH regulator, 0.5 part of an anti-inflammatory agent, 0.02 part of a bacteriostatic agent and 93.28 parts of purified water.

Preferably, the humectant is sodium hyaluronate, glycerin, butanediol and beta glucan in a mass ratio of 1:5:5: 4.

Preferably, the plant extract is a witch hazel extract and a purslane extract, and the mass ratio of the witch hazel extract to the purslane extract is 1: 1.

Preferably, the thickener used is hydroxyethyl cellulose; the pH regulator is citric acid and lactic acid, and the mass ratio of the citric acid to the lactic acid is 1: 2; the anti-inflammatory agent is dipotassium glycyrrhizinate and allantoin, and the mass ratio of the dipotassium glycyrrhizinate to the allantoin is 2: 1; the used bacteriostatic agent is chlorhexidine gluconate and domiphen bromide with the mass ratio of 4: 1.

Example 2

A fullerene maintenance antibacterial gel is composed of the following raw materials in parts by mass: the anti-inflammatory and antibacterial agent comprises, by weight, 600.4 parts of fullerene C, 0.3 part of gene recombinant human collagen, 0.8 part of a humectant, 3 parts of a plant extract, 0.8 part of a thickening agent, 0.3 part of a pH regulator, 0.5 part of an anti-inflammatory agent, 0.02 part of a bacteriostatic agent and 93.88 parts of purified water.

Preferably, the plant extract is an extract of cacumen biotae and an extract of phellodendron amurense, and the mass ratio of the extract to the extract is 1: 1.

Preferably, the used thickening agent is sodium carboxymethyl cellulose and xanthan gum, and the mass ratio of the sodium carboxymethyl cellulose to the xanthan gum is 1: 2; the pH regulator is lactic acid and malic acid in a mass ratio of 1: 2; the anti-inflammatory agent is allantoin and PCA-Zn, and the mass ratio of the allantoin to the PCA-Zn is 1: 1; the used bacteriostatic agent is benzalkonium chloride and domiphen bromide in the mass ratio of 3: 1.

Example 3

A fullerene maintenance antibacterial gel is composed of the following raw materials in parts by mass: 600.5 parts of fullerene C, 0.5 part of gene recombinant human collagen, 2.5 parts of humectant, 4 parts of plant extract, 1 part of thickening agent, 0.3 part of pH regulator, 1 part of anti-inflammatory agent, 0.04 part of bacteriostatic agent and 90.16 parts of purified water.

Preferably, the humectant used is glycerin and butylene glycol in a mass ratio of 2: 3.

Preferably, the plant extract is a witch hazel extract and a phellodendron extract, and the mass ratio of the witch hazel extract to the phellodendron extract is 1: 1.

Preferably, the used thickening agent is gellan gum and carrageenan, and the mass ratio of the gellan gum to the carrageenan is 1: 1; the pH regulator is lactic acid and malic acid, and the mass ratio of the lactic acid to the malic acid is 2: 1; the anti-inflammatory agent is dipotassium glycyrrhizinate; the used bacteriostatic agent is benzalkonium chloride and domiphen bromide in the mass ratio of 1: 1.

Example 4

A fullerene maintenance antibacterial gel is composed of the following raw materials in parts by mass: 600.2 parts of fullerene C, 0.1 part of gene recombinant human collagen, 0.1 part of humectant, 1 part of plant extract, 0.2 part of thickening agent, 0.1 part of pH regulator, 0.1 part of anti-inflammatory agent, 0.01 part of bacteriostatic agent and 90.16 parts of purified water.

Preferably, the humectant is beta glucan and betaine, and the mass ratio of the beta glucan to the betaine is 2: 3.

Preferably, the plant extract is a witch hazel extract and a purslane extract, and the mass ratio of the witch hazel extract to the purslane extract is 1: 3.

Preferably, the used thickening agent is carrageenan and starch, and the mass ratio of the carrageenan to the starch is 2: 1; the pH regulator is citric acid and lactic acid, and the mass ratio of the citric acid to the lactic acid is 1: 1; the anti-inflammatory agent used is allantoin; the used bacteriostatic agent is domiphen bromide and triclosan, and the mass ratio of the bacteriostatic agent to the domiphen bromide is 1: 2.

Example 5

A fullerene maintenance antibacterial gel is composed of the following raw materials in parts by mass: the antibacterial agent comprises, by weight, 601.0 parts of fullerene C, 1.0 part of gene recombinant human collagen, 12 parts of a humectant, 6 parts of a plant extract, 3 parts of a thickening agent, 0.8 part of a pH regulator, 3 parts of an anti-inflammatory agent, 0.8 part of a bacteriostatic agent and 72.4 parts of purified water.

Preferably, the humectant is beta glucan and betaine in a mass ratio of 1: 1.

Preferably, the plant extract is a witch hazel extract.

Preferably, the thickening agent used is xanthan gum and pectin in a mass ratio of 1: 2; the pH regulator is citric acid; the anti-inflammatory agent is dipotassium glycyrrhizinate; the used bacteriostatic agent is chlorhexidine gluconate and benzalkonium chloride, and the mass ratio of the bacteriostatic agent to the chlorhexidine gluconate to the benzalkonium chloride is 1: 3.

Example 6

A fullerene maintenance antibacterial gel is composed of the following raw materials in parts by mass: the anti-inflammatory and antibacterial agent comprises, by weight, 600.8 parts of fullerene C, 0.8 part of gene recombinant human collagen, 10 parts of a humectant, 5 parts of a plant extract, 2 parts of a thickening agent, 0.5 part of a pH regulator, 2 parts of an anti-inflammatory agent, 0.5 part of a bacteriostatic agent and 78.4 parts of purified water.

Preferably, the humectant used is beta glucan.

Preferably, the plant extract is a witch hazel extract.

Preferably, the thickener used is carrageenan; the pH regulator is citric acid and lactic acid, and the mass ratio of the citric acid to the lactic acid is 1: 1; the anti-inflammatory agent used is allantoin; the bacteriostatic agent used is domiphen bromide.

Comparative example 1

A nursing antibacterial gel is composed of the following raw materials in parts by weight: 0.3 part of gene recombinant human collagen, 1.5 parts of humectant, 3 parts of plant extract, 1 part of thickening agent, 0.3 part of PH regulator, 0.5 part of anti-inflammatory agent, 0.02 part of bacteriostatic agent and 93.38 parts of purified water.

Preferably, the humectant is sodium hyaluronate, glycerin, butanediol and beta glucan in a mass ratio of 2:5:5: 2.

Preferably, the plant extracts are a witch hazel extract and a purslane extract, and the mass ratio of the witch hazel extract to the purslane extract is 1: 1.

Preferably, the thickener used is hydroxyethyl cellulose; the pH regulator is citric acid and lactic acid, and the mass ratio of the citric acid to the lactic acid is 1: 2; the anti-inflammatory agent is dipotassium glycyrrhizinate and allantoin, and the mass ratio of the dipotassium glycyrrhizinate to the allantoin is 1: 1; the used bacteriostatic agent is benzalkonium chloride and domiphen bromide in the mass ratio of 1: 1.

Comparative example 2

A nursing antibacterial gel is composed of the following raw materials in parts by weight: 0.4 part of gene recombinant human collagen, 1.5 parts of humectant, 3 parts of plant extract, 1 part of thickening agent, 0.3 part of pH regulator, 0.5 part of anti-inflammatory agent, 0.02 part of bacteriostatic agent and 93.28 parts of purified water.

Preferably, the humectant is sodium hyaluronate, glycerin, butanediol and beta glucan in a mass ratio of 2:5:5: 4.

Preferably, the thickener used is hydroxyethyl cellulose; the pH regulator is citric acid and lactic acid, and the mass ratio of the citric acid to the lactic acid is 1: 2; the anti-inflammatory agents of dipotassium glycyrrhizinate and allantoin are used, and the mass ratio of the dipotassium glycyrrhizinate to the allantoin is 1: 1; the used bacteriostatic agent is benzalkonium chloride and domiphen bromide in the mass ratio of 2: 1.

Comparative example 3

A nursing antibacterial gel is composed of the following raw materials in parts by weight: 0.5 part of gene recombinant human collagen, 1.5 parts of humectant, 3 parts of plant extract, 1 part of thickening agent, 0.3 part of PH regulator, 0.5 part of anti-inflammatory agent, 0.02 part of bacteriostatic agent and 93.18 parts of purified water.

Preferably, the thickener used is hydroxyethyl cellulose; the pH regulator is citric acid and lactic acid, and the mass ratio of the citric acid to the lactic acid is 1: 2; the anti-inflammatory agents of dipotassium glycyrrhizinate and allantoin are used, and the mass ratio of the dipotassium glycyrrhizinate to the allantoin is 1: 1; the used bacteriostatic agent is benzalkonium chloride and domiphen bromide in the weight ratio of 4 to 1.

The preparation of the bacteriostatic gel in the above example is carried out according to the following steps:

performance testing

1. And (3) testing the elasticity of the skin on the inner side of the arm:

10 volunteers were recruited, the specific procedure was as follows:

(1) after cleaning the inner side of the arm, the tester naturally dries the arm, sits for 15 minutes in a room with constant temperature and certain humidity, marks the arm of the tester, performs blank test, and records skin elasticity data.

(2) Continuously coating fullerene maintenance antibacterial gel and kernel and herb maintenance gel on the market every day, carrying out data tracking recording on 3, 6, 9, 12 and 15 days after use, and calculating the data of skin elasticity, wherein the specific elasticity data are shown in table 1:

TABLE 1 skin elasticity data for examples 1-6, comparative examples 1-3 and pome and herbal care gels

Elasticity increasing Rate (%)	Day 0	Day 3	Day 6	Day 9	Day 12	Day 15
							Example 1	0	3.15	3.34	5.46	7.76	8.25
Example 2	0	4.40	4.30	6.29	8.04	9.75
							Example 3	0	5.0	4.48	8.10	9.53	10.78
Example 4	0	4.2	4.01	6.69	8.73	11.72
							Example 5	0	4.66	4.67	7.89	11.35	13.42
Example 6	0	5.63	5.56	9.78	12.45	14.36
							Comparative example 1	0	3.02	2.76	3.45	4.58	6.67
Comparative example 2	0	4.56	4.21	4.76	5.01	6.98
							Comparative example 3	0	4.56	4.10	5.42	6.00	7.23
Kernel and herbal care gel	0	3.53	4.57	4.62	6.18	6.78

The test result shows that the fullerene maintenance antibacterial gel can increase the elasticity of the skin after long-term use, the change trend of the fullerene maintenance antibacterial gel rises in a curve, the highest value is reached after the test is finished, the effect of the fullerene maintenance antibacterial gel is obviously superior to that of the test gel of the comparative example, the fullerene maintenance antibacterial gel can obviously increase the elasticity of the skin, meanwhile, the collagen content of the skin is increased, the moisture-holding capacity of the horny layer is enhanced, and the elasticity of the skin is increased, so that the fullerene maintenance antibacterial gel can tighten the skin and increase the elasticity; the gels and core and herbal care gels of comparative examples 1-3, without fullerene C60, were less elastic.

2. Bacteriostasis test

The bacteriostatic test mainly adopts a suspension method to test the bacteriostatic effect of the fullerene curing bacteriostatic gel on candida albicans, staphylococcus aureus and escherichia coli, and the specific operation method is as follows:

1. preparing a bacterial suspension: before experiment, the working strain is streaked and inoculated on an agar slant, the agar slant is cultured for 24h at 36.0 ℃, and the slant of the cultured test strain is washed by 0.03mol/LPBS to prepare bacterial suspension.

2. The detection method comprises the following steps: 5mL of the test sample solution and 4 tubes of the control sample solution were each sampled.

And (3) taking the bacterial suspension, respectively dripping 100 mu L of the bacterial suspension on each sample to be tested and each control sample, uniformly mixing, starting timing, acting for 2min, 5min, 10min and 20min, sucking 0.5mL of sample liquid, adding the sample liquid into a test tube containing 5.0mL of PBS, fully and uniformly mixing, diluting, then taking 2-3 dilutions, sucking 0.5mL of the dilutions respectively, placing the dilutions in 2 plates, rotating the plates by using a culture medium cooled to 45 ℃, fully and uniformly stirring, turning the plates after agar is solidified, culturing for 48 hours at 36.0 ℃, and counting viable bacteria colonies.

The bacteriostatic rate was calculated as follows:

X₄＝(A-B)/A×100％

in the formula: x₄Percent is the bacteriostatic rate;

a is the average colony number of the control sample;

b is the average colony number of the test sample.

The bacteriostatic rate is more than or equal to 50-90%, the product has bacteriostatic action, the bacteriostatic rate is more than or equal to 90%, the product has strong bacteriostatic action, examples 1-6 and comparative examples 1-3, and the bacteriostatic test results of the existing gels (DoctorYang bacteriostatic gel and Sunday whisper bacteriostatic gel) in the market are shown in Table 2:

TABLE 2 results of bacteriostasis tests on examples 1-6, comparative examples 1-3 and commercial gels

The test results in table 2 show that the fullerene maintenance antibacterial gel of the embodiments 1 to 6 of the invention can not only increase the skin elasticity, but also has excellent antibacterial effects on candida albicans, staphylococcus aureus and escherichia coli; the gels of comparative examples 1-3 have relatively poor effect on candida albicans, and the carrier Yang bacteriostatic gel and summer whisper bacteriostatic gel on the market have no bacteriostatic effect as the fullerene curing bacteriostatic gel.

The gel disclosed by the invention adopts antibacterial components in a reasonable proportion, the components are safe and non-irritant, and the gel disclosed by the invention has an obvious effect on resisting free radicals and preventing organism aging through synergistic interaction among the components, and has excellent antibacterial performance.

The antibacterial gel is prepared by compounding fullerene C60, gene recombinant human collagen, a humectant, a plant extract, a thickening agent, a pH regulator, an anti-inflammatory agent, a bacteriostatic agent and purified water according to the mass ratio of 1:1, wherein the fullerene C60 and the gene recombinant human collagen can resist free radicals of organisms, activate cells and play an external protection effect, and the gene recombinant human collagen has excellent biocompatibility, can adjust the synthesis of human collagen and plays an internal maintenance effect; the Hamamelis virginiana extract selected by the invention has the effects of anti-inflammation and convergence, the phellodendron extract and the cacumen biotae extract have excellent antibacterial and antiviral effects, and the purslane extract has the effects of anti-allergy and anti-inflammation.

Because the plant extracts have anti-inflammatory or antibacterial and antiviral effects, when the fullerene curing and bacteriostasis gel is prepared, the antibacterial effect and the effect of removing free radicals can be achieved by selecting different plant extracts, and the anti-inflammatory or antibacterial and antiviral emphasis points are different.

The fullerene C60 used in the invention is the minimum molecule reaching a stable structure in a fullerene spherical structure, so that the fullerene C60 has relatively small molecular weight and is easy to be absorbed by skin while having stable property, can be compatible with free radicals generated by organisms, has high-efficiency oxidation resistance, can play a role in activating cells and preventing skin from fading, and can remarkably enhance the skin elasticity and tighten the skin after being used for a long time by adding the fullerene C60 into a system;

the gene recombinant human collagen selected by the invention is type III collagen, is collagen with very rich content in fibrous collagen, has complete affinity and excellent biocompatibility with human source fragments, is more beneficial to skin absorption, can increase fibroblasts after long-term use, regulates the collagen synthesis of a human body, and promotes the skin elasticity to increase.

While the preferred embodiments of the present invention have been described in detail, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.

Many other changes and modifications can be made without departing from the spirit and scope of the invention. It is to be understood that the invention is not to be limited to the specific embodiments, but only by the scope of the appended claims.

Claims

1. The fullerene curing antibacterial gel is characterized by comprising the following raw materials in parts by mass: 0.2-1.0 part of fullerene C60, 0.1-1.0 part of gene recombinant human collagen, 0.1-12 parts of humectant, 1-6 parts of plant extract, 0.2-3 parts of thickener, 0.1-0.8 part of PH regulator, 0.1-3 parts of anti-inflammatory agent, 0.01-0.8 part of bacteriostatic agent and 72.4-98.19 parts of purified water.

2. The fullerene curing bacteriostatic gel according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 0.2-0.8 part of fullerene C60, 0.1-0.8 part of gene recombinant human collagen, 0.1-10 parts of humectant, 2-5 parts of plant extract, 0.5-2 parts of thickener, 0.1-0.5 part of PH regulator, 0.1-2 parts of anti-inflammatory agent, 0.01-0.5 part of bacteriostatic agent and 78.4-96.89 parts of purified water.

3. The fullerene curing antibacterial gel according to claim 2, wherein the raw materials in parts by weight are: 0.5 part of fullerene C60, 0.5 part of gene recombinant human collagen, 2.5 parts of humectant, 4 parts of plant extract, 1 part of thickening agent, 0.3 part of PH regulator, 1 part of anti-inflammatory agent, 0.04 part of bacteriostatic agent and 90.16 parts of purified water.

4. A fullerene maintenance bacteriostatic gel according to claim 3, wherein: the humectant is selected from one or more of sodium hyaluronate, glycerin, butanediol, beta glucan and betaine; the plant extract is one or more selected from cacumen Platycladi extract, Hamamelis virginiana extract, cortex Phellodendri extract, and herba Portulacae extract; the thickening agent is one or more selected from sodium carboxymethylcellulose, hydroxyethyl cellulose, xanthan gum, pectin, guar gum, gellan gum, carrageenan and starch.

5. A fullerene maintenance bacteriostatic gel according to claim 3, wherein: the pH regulator is one or more selected from citric acid, lactic acid and malic acid; the anti-inflammatory agent is one or more selected from dipotassium glycyrrhizinate, allantoin and PCA-Zn; the bacteriostatic agent is selected from one or more of chlorhexidine gluconate, benzalkonium chloride, domiphen bromide and triclosan.

6. A fullerene maintenance bacteriostatic gel according to claim 3, wherein: the mass ratio of the fullerene C60 to the gene recombinant human collagen is 1: 1.

7. a preparation method of fullerene curing bacteriostatic gel as claimed in any one of claims 1 to 6, characterized by comprising the following steps: