CN109620798A - It is a kind of to resist antibacterial secret nursing gel for anti-gynecological disease - Google Patents
It is a kind of to resist antibacterial secret nursing gel for anti-gynecological disease Download PDFInfo
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Abstract
The present invention relates to bacteriostatic gel technical fields, and in particular to a kind of for preventing and treating the antibacterial secret nursing gel of gynecological disease；Described resists antibacterial secret nursing gel to include following weight percent raw material: water 86.0 ~ 90.0%, Acritamer 940 0.3 ~ 0.5%, glycerol 3.0 ~ 5.0%, butanediol 3.0 ~ 5.0%, allantoin 0.1 ~ 0.2%, methyl hydroxybenzoate 0.1 ~ 0.2%, collargol 0.5 ~ 1.5%, chlorhexidine gluconate 0.05 ~ 0.15%, chlorhexidine acetate 0.05 ~ 0.15%, borneol 0.02 ~ 0.15%, shrubby sophora extract 0.2 ~ 3.0%, common cnidium fruit P.E 0.2 ~ 3.0%, chitosan 0.05 ~ 3.0%, triethanolamine 0.3 ~ 0.5%, fuller olefinic carbon 60 .02 ~ 0.2%, polyquaternium -37 1.5 ~ 2.5%, 1, 2- hexylene glycol 0.1 ~ 0 .2%, Phenoxyethanol 0.09 ~ 0.2%, Sensiva SC50 0.03 ~ 0.1%, PEG-40 rilanit special 0.1 ~ 0.3%, menthol 0.01 ~ 0.05%.The nursing gel is by being added to the plurality of active ingredients such as shrubby sophora extract, common cnidium fruit P.E, collargol, chlorhexidine gluconate, chlorhexidine acetate and fullerene, obtained nursing gel has very strong bacteriostasis to staphylococcus aureus, Escherichia coli, Candida albicans, it is non-stimulated to vagina mucosa, and to skin also vacuum response.
Description
Technical field
The present invention relates to bacteriostatic gel technical fields, and in particular to a kind of antibacterial secret nursing for preventing and treating gynecological disease
Gel and preparation method thereof.
Background technique
The disease of female reproductive system is gynecological disease, including vulva disease, vaginal disease, uterine disease, fallopian tubal
Disease, disease of ovary etc..Gynecological disease is women common disease, frequently-occurring disease.But since many people are due to gynecological disease shortage
Understanding lacks the health care to body, and various bad life habits etc., make physiological health go from bad to worse in addition, lead to some women
It is eaten up with illness, and obstinate, it is greatly inconvenient to come to normal life, work belt.
According to World Health Organization's incomplete statistics the results show that various gynecological disease disease incidence are 65% or more in women.
Development, people's lives mode and behavior with society are constantly changing, reproductive tract infection, menstrual disorder and mammary gland disease etc.
Illness rate gradually increasing.Gynecological infectious diseases are a kind of common disease and frequently-occurring disease, especially colpomycosis, uterine neck
Rotten to the corn and senile vahinitis disease incidence is very high.
Improve vaginal microenvironment, repair vagina micro-damage, maintains microecology in vaginas balance, improve vagina cleanness degree, improve
Vagina mucosa immunity is of great significance for treatment vagina common disease, while to consider to avoid using antibiotic
The drug resistance that is caused, suprainfection, allergic reaction and to drawbacks such as the toxic side effects of body.The woman occurred currently on the market
Section's gel mainly achievees the purpose that treat gynaecological disease by inhibiting disinfect pathogen, also kill while killing pathogenic bacteria
Many probiotics lead to intravaginal flora imbalance, vagina hypoimmunity, to cause vaginitis recurrent exerbation, can not eradicate,
It can only simply nurse, fungistatic effect is undesirable, cannot inhibit microbial reproduction for a long time, cannot accomplish effectively to kill harmful micro- life
Object, and the raw material irritation used is big, and residual is strong, cannot dissolve in intravaginal.
Therefore, how to provide it is a kind of resist antibacterial secret nursing gel for effective anti-gynecological disease, can be simultaneously
Lasting health care and the microecological balance for maintaining vagina prevent and treat the unbalance mesh of microecology in vaginas of women to reach
, it is the important problem put in face of vast scientific research and medical personnel.
Product of the present invention using new raw material and technology change in the market product there are the problem of, for golden in vagina
The breeding of staphylococcus aureus, Escherichia coli, Candida albicans, gonococcus, fungi, saccharomycete etc. and effectively kill and develop,
Prevention and improvement gynecological disease, are effectively relieved the treatment of gynecology colpitis, cervicitis, comprising: bacterial vaginitis, trichomonas yin
Road inflammation, Combination vaginitis, gonococcal infection, chronic cervicitis, cervical erosion.With anti-inflammatory, sterilization, itching-relieving action.
Summary of the invention
Technical problem to be solved by the present invention lies in provide a kind of antibacterial secret nursing for preventing and treating gynecological disease
Gel, the nursing gel is by being added to shrubby sophora extract, common cnidium fruit P.E, collargol, chlorhexidine gluconate, vinegar
The plurality of active ingredients such as sour Chlorhexidine and fullerene, obtained nursing gel is to staphylococcus aureus, Escherichia coli, white
Candida albicans has very strong bacteriostasis, non-stimulated to vagina mucosa, and to skin also vacuum response.
Above-mentioned technical problem to be solved by this invention, is achieved by following technical solution:
It is a kind of for preventing and treating the antibacterial secret nursing gel of gynecological disease, described resists antibacterial secret nursing gel to include following weight
Measure percentage raw material: water 86.0 ~ 90.0%, Acritamer 940 0.3 ~ 0.5%, glycerol 3.0 ~ 5.0%, butanediol 3.0 ~ 5.0%, allantois
Element 0.1 ~ 0.2%, methyl hydroxybenzoate 0.1 ~ 0.2%, collargol 0.5 ~ 1.5%, chlorhexidine gluconate 0.05 ~ 0.15%, acetic acid chlorine oneself
Fixed 0.05 ~ 0.15%, borneol 0.02 ~ 0.15%, shrubby sophora extract 0.2 ~ 3.0%, common cnidium fruit P.E 0.2 ~ 3.0%, chitosan
0.05 ~ 3.0%, triethanolamine 0.3 ~ 0.5%, fuller olefinic carbon 60 .02 ~ 0.2%, polyquaternium -37 1.5 ~ 2.5%, 1,2- hexylene glycol 0.1
~ 0.2%, Phenoxyethanol 0.09 ~ 0.2%, Sensiva SC50 0.03 ~ 0.1%, PEG-40 rilanit special 0.1 ~ 0.3%, peppermint
Brain 0.01 ~ 0.05%.
As a preferred embodiment, described that antibacterial secret nursing gel is resisted to include following weight percent raw material: water
86.12%, Acritamer 940 0.4%, glycerol 3.3%, butanediol 3.4%, allantoin 0.15%, methyl hydroxybenzoate 0.15%, collargol 1%,
Chlorhexidine gluconate 0.1%, chlorhexidine acetate 0.1%, borneol 0.06%, shrubby sophora extract 1%, common cnidium fruit P.E 1%, shell are poly-
Sugar 0.2%, triethanolamine 0.4%, fuller olefinic carbon 60 .08%, polyquaternium -37 2%, 1,2- hexylene glycol 0.15%, Phenoxyethanol 0.12%,
Sensiva SC50 0.05%, PEG-40 rilanit special 0.2%, menthol 0.02%.
As a preferred embodiment, the shrubby sophora extract is prepared by the inclusion of the method for following steps:
A, kuh-seng is selected, shaking weeds out except impurity, be broken into kuh-seng powder；
B, after soaking broken kuh-seng with 2 ~ 3 times of amount water, 90 ~ 100 DEG C of hot water for being continuously added into 20 ~ 25 times of amounts are continuously inverse
Stream extract 1 ~ 2h, collect extracting solution, kuh-seng residue is then exhausted from after squeezing recovery section liquid, the partially liq of recycling with mention
Liquid is taken to merge；The input speed of the kuh-seng powder is 90 ~ 110kg/h, and the reverse flow velocity that hot water is added is 1800 ~ 2200L/h；
C, the extracting solution after merging filters after being cooled to 70 ~ 75 DEG C, and filtrate sterilizes 12 ~ 14 seconds at 155 ~ 160 DEG C, then 63 ~
It is concentrated under reduced pressure at 65 DEG C, it is dry at 75 DEG C ~ 83 DEG C, obtain shrubby sophora extract.
As a preferred embodiment, the common cnidium fruit P.E is prepared by the inclusion of the method for following steps:
Dry frutus cnidii is taken, the mass fraction that 12 ~ 18 times of its weight amounts are added after crushing is 10 ~ 15% sodium chloride solutions, is impregnated
60 ~ 80min, 6 ~ 9min of microwave treatment under the power of 600 ~ 750W, then 4 ~ 5h of steam distillation is carried out, distillate is collected, i.e.,
Obtain common cnidium fruit P.E.
As a preferred embodiment, the preparation method for resisting antibacterial secret nursing gel for anti-gynecological disease,
It is prepared by the inclusion of the method for following steps:
(1) it weighs required water, Acritamer 940, glycerol, allantoin, methyl hydroxybenzoate, chitosan to be added in emulsifier unit, heating
To 83 ~ 85 DEG C, the stirring of 18 ~ 30r/min speed and homogeneous 2 ~ 5 minutes, then constant temperature 10 ~ 20 minutes；
(2) it weighs triethanolamine to be added in emulsifier unit, the stirring of 15 ~ 25 r/min speed is evacuated to -0.05 ~ -0.01Mpa；
(3) butanediol, chlorhexidine acetate, borneol, menthol are weighed in a reservoir and to be heated to 75 ~ 78 DEG C of dissolutions transparent, then plus
Enter PEG-40 rilanit special, is added in emulsifier unit by the raw material dissolved in container, the stirring of 17 ~ 23r/min speed,
It is evacuated to -0.06 ~ -0.02Mpa, begins to cool cooling；
(4) 25 ~ 45 DEG C are cooled to, chlorhexidine gluconate is weighed respectively, shrubby sophora extract, common cnidium fruit P.E, fullerene, gathers
Quaternary ammonium salt -37, collargol are added 15 ~ 25r/min speed in emulsifier unit and stir 12 ~ 18 minutes；
(5) 1,2- hexylene glycol, Phenoxyethanol, Sensiva SC50 are weighed to be uniformly mixed, is added in emulsifier unit, 17 ~ 27r/min
Speed stirs 18 ~ 24 minutes to clear gel, after conventional physical and chemical inspection to obtain the final product.
As a preferred embodiment, the preparation method of the antibacterial secret nursing gel for preventing and treating gynecological disease,
Temperature after heating described in step (1) is 83 ~ 85 DEG C；The speed of stirring is 18 ~ 30r/min；Homogenizing time is 2 ~ 5 minutes；
Constant temperature time is 10 ~ 20 minutes.
As a preferred embodiment, the preparation method of the antibacterial secret nursing gel for preventing and treating gynecological disease,
The speed of stirring described in step (2) is 15 ~ 25 r/min；Pressure after vacuumizing is -0.05 ~ -0.01Mpa.
As a preferred embodiment, the preparation method of the antibacterial secret nursing gel for preventing and treating gynecological disease,
Temperature after heating described in step (3) is 75 ~ 78 DEG C；The speed of stirring is 17 ~ 23r/min；Pressure after vacuumizing is-
0.06~-0.02Mpa。
As a preferred embodiment, the preparation method of the antibacterial secret nursing gel for preventing and treating gynecological disease,
Temperature after cooling down described in step (4) is 25 ~ 45 DEG C；The speed of stirring be 15 ~ 25r/min, mixing time 12 ~ 18 minutes.
As a preferred embodiment, the preparation method of the antibacterial secret nursing gel for preventing and treating gynecological disease,
The speed of stirring described in step (5) is 17 ~ 27r/min, and mixing time is 18 ~ 24 minutes.
The utility model has the advantages that it is of the present invention for preventing and treating the antibacterial secret nursing gel of gynecological disease, by adding colloidal state
The plurality of active ingredients such as silver-colored, fullerene and the shrubby sophora extract being prepared by the method for the invention, common cnidium fruit P.E, then
In addition the scientific and reasonable proportion of other raw materials, rationally controls preparation parameter and is made；The nursing gel is in vagina
Staphylococcus aureus, Escherichia coli, Candida albicans have very strong bacteriostasis, it is non-stimulated to vagina mucosa, and to skin
Skin also vacuum response；Long to the bacteriostasis efficacy duration in vagina, lasting effect is good；It effectively can prevent and improve woman
The treatment of gynecology colpitis, cervicitis is effectively relieved in section's disease, comprising: bacterial vaginitis, trichomonas vaginitis, Combination
Vaginitis, gonococcal infection, chronic cervicitis, cervical erosion；With anti-inflammatory, sterilization, itching-relieving action；Each group in composition of raw materials
Divide and complement each other, has the function of synergy to the prepared bacteriostasis for obtaining nursing gel, and humidification is significant.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described, it is clear that described embodiments are some of the embodiments of the present invention, rather than
Whole embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not making creative work premise
Under every other embodiment obtained, shall fall within the protection scope of the present invention.
Embodiment 1 is a kind of for preventing and treating the antibacterial secret nursing gel of gynecological disease
Composition of raw materials: water 86.12%, Acritamer 940 0.4%, glycerol 3.3%, butanediol 3.4%, allantoin 0.15%, methyl hydroxybenzoate
0.15%, collargol 1%, chlorhexidine gluconate 0.1%, chlorhexidine acetate 0.1%, borneol 0.06%, shrubby sophora extract 1%, cnidium monnieri
Seed extract 1%, chitosan 0.2%, triethanolamine 0.4%, fuller olefinic carbon 60 .08%, polyquaternium -37 2%, 1,2- hexylene glycol
0.15%, Phenoxyethanol 0.12%, Sensiva SC50 0.05%, PEG-40 rilanit special 0.2%, menthol 0.02%.
The shrubby sophora extract is prepared by following steps:
A, kuh-seng is selected, shaking weeds out except impurity, be broken into kuh-seng powder；
B, after soaking broken kuh-seng with 2.5 times of amount water, 97 DEG C of hot water Continuous Countercurrent Extractions of 22 times of amounts are continuously added into
1.5h collects extracting solution, kuh-seng residue is then exhausted from after squeezing recovery section liquid, and the partially liq and extracting solution of recycling close
And；The input speed of the kuh-seng powder is 105kg/h, and the reverse flow velocity that hot water is added is 2000L/h；
C, the extracting solution after merging filters after being cooled to 73 DEG C, and filtrate sterilizes 13 seconds at 158 DEG C, then depressurizes at 64 DEG C dense
It contracts, it is dry at 78 DEG C, obtain shrubby sophora extract.
The common cnidium fruit P.E is prepared by following steps:
Dry frutus cnidii is taken, the mass fraction that 16 times of its weight amounts are added after crushing is 13% sodium chloride solution, is impregnated
75min, the microwave treatment 8min under the power of 700W, then steam distillation 4.5h is carried out, it collects distillate and is mentioned to get frutus cnidii
Take object.
The antibacterial secret nursing gel for preventing and treating gynecological disease is prepared by following steps:
(1) it weighs required water, Acritamer 940, glycerol, allantoin, methyl hydroxybenzoate, chitosan to be added in emulsifier unit, heating
To 84 DEG C, the stirring of 20r/min speed and homogeneous 3 minutes, then constant temperature 15 minutes；
(2) it weighs triethanolamine to be added in emulsifier unit, the stirring of 20 r/min speed is evacuated to -0.03Mpa；
(3) butanediol, chlorhexidine acetate, borneol, menthol are weighed in a reservoir and to be heated to 77 DEG C of dissolutions transparent, is added
PEG-40 rilanit special is added in emulsifier unit by the raw material dissolved in container, and the stirring of 20r/min speed vacuumizes
To -0.03Mpa, cooling is begun to cool；
(4) 30 DEG C are cooled to, weighs chlorhexidine gluconate, shrubby sophora extract, common cnidium fruit P.E, fullerene, poly- season respectively
Ammonium salt -37, collargol are added 20r/min speed in emulsifier unit and stir 15 minutes；
(5) 1,2- hexylene glycol, Phenoxyethanol, Sensiva SC50 are weighed to be uniformly mixed, is added in emulsifier unit, 20r/min speed
Degree stirring 20 minutes to clear gel, after conventional physical and chemical inspection to obtain the final product.
Embodiment 2 is a kind of for preventing and treating the antibacterial secret nursing gel of gynecological disease
Nursing gel described in embodiment 2 difference from example 1 is that, prepare preparation parameter during nursing gel not
Together；
The antibacterial secret nursing gel for preventing and treating gynecological disease is prepared by following steps:
(1) it weighs required water, Acritamer 940, glycerol, allantoin, methyl hydroxybenzoate, chitosan to be added in emulsifier unit, heating
To 83 DEG C, the stirring of 18r/min speed and homogeneous 2 minutes, then constant temperature 10 minutes；
(2) it weighs triethanolamine to be added in emulsifier unit, the stirring of 15 r/min speed is evacuated to -0.05Mpa；
(3) butanediol, chlorhexidine acetate, borneol, menthol are weighed in a reservoir and to be heated to 75 DEG C of dissolutions transparent, is added
PEG-40 rilanit special is added in emulsifier unit by the raw material dissolved in container, and the stirring of 17r/min speed vacuumizes
To -0.06Mpa, cooling is begun to cool；
(4) 25 DEG C are cooled to, weighs chlorhexidine gluconate, shrubby sophora extract, common cnidium fruit P.E, fullerene, poly- season respectively
Ammonium salt -37, collargol are added 15r/min speed in emulsifier unit and stir 12 minutes；
(5) 1,2- hexylene glycol, Phenoxyethanol, Sensiva SC50 are weighed to be uniformly mixed, is added in emulsifier unit, 17r/min speed
Degree stirring 18 minutes to clear gel, after conventional physical and chemical inspection to obtain the final product.
Embodiment 3 is a kind of for preventing and treating the antibacterial secret nursing gel of gynecological disease
Nursing gel described in embodiment 3 difference from example 1 is that, prepare preparation parameter during nursing gel not
Together；
The antibacterial secret nursing gel for preventing and treating gynecological disease is prepared by following steps:
(1) it weighs required water, Acritamer 940, glycerol, allantoin, methyl hydroxybenzoate, chitosan to be added in emulsifier unit, heating
To 85 DEG C, the stirring of 30r/min speed and homogeneous 5 minutes, then constant temperature 20 minutes；
(2) it weighs triethanolamine to be added in emulsifier unit, the stirring of 25 r/min speed is evacuated to -0.01Mpa；
(3) butanediol, chlorhexidine acetate, borneol, menthol are weighed in a reservoir and to be heated to 78 DEG C of dissolutions transparent, is added
PEG-40 rilanit special is added in emulsifier unit by the raw material dissolved in container, and the stirring of 23r/min speed is taken out true
Empty extremely -0.02Mpa, begins to cool cooling；
(4) 45 DEG C are cooled to, weighs chlorhexidine gluconate, shrubby sophora extract, common cnidium fruit P.E, fullerene, poly- season respectively
Ammonium salt -37, collargol are added 25r/min speed in emulsifier unit and stir 18 minutes；
(5) 1,2- hexylene glycol, Phenoxyethanol, Sensiva SC50 are weighed to be uniformly mixed, is added in emulsifier unit, 27r/min speed
Degree stirring 24 minutes to clear gel, after conventional physical and chemical inspection to obtain the final product.
Comparative example 1
Comparative example 1 difference from example 1 is that, in composition of raw materials add 2.08% fullerene, do not add kuh-seng extraction
Object and common cnidium fruit P.E, remaining component and content are same as Example 1；The preparation method of gel is also same as Example 1.
Comparative example 2
Comparative example 2 difference from example 1 is that, in composition of raw materials add 2.08% shrubby sophora extract, do not add fowler
Alkene and common cnidium fruit P.E, remaining component and content are same as Example 1；The preparation method and embodiment of the shrubby sophora extract
1 is identical, and the preparation method of gel is also same as Example 1.
Comparative example 3
Comparative example 3 difference from example 1 is that, in composition of raw materials add 2.08% common cnidium fruit P.E, do not add richness
It strangles alkene and shrubby sophora extract, remaining component and content is same as Example 1；The preparation method and implementation of the common cnidium fruit P.E
Example 1 is identical, and the preparation method of gel is also same as Example 1.
Comparative example 4
Comparative example 4 difference from example 1 is that, 0.58% fullerene and 1.5% kuh-seng are added in composition of raw materials and is mentioned
Object is taken, common cnidium fruit P.E is not added, remaining component and content are same as Example 1；The preparation method of the shrubby sophora extract
Same as Example 1, the preparation method of gel is also same as Example 1.
Comparative example 5
Comparative example 5 difference from example 1 is that, 0.58% fullerene and 1.5% frutus cnidii are added in composition of raw materials
Extract does not add shrubby sophora extract, remaining component and content are same as Example 1；The preparation side of the common cnidium fruit P.E
Method is same as Example 1, and the preparation method of gel is also same as Example 1.
Comparative example 6
Comparative example 6 difference from example 1 is that, 1.04% shrubby sophora extract and 1.04% snake are added in composition of raw materials
Machine tool extract, does not add fullerene, remaining component and content are same as Example 1；The shrubby sophora extract and frutus cnidii mention
Take the preparation method of object same as Example 1, the preparation method of gel is also same as Example 1.
Comparative example 7
Comparative example 7 difference from example 1 is that, substituted with commercially available shrubby sophora extract by this hair in composition of raw materials
The shrubby sophora extract that bright the method is prepared, remaining component and content are same as Example 1.
Comparative example 8
Comparative example 8 difference from example 1 is that, in composition of raw materials with commercially available common cnidium fruit P.E come substitute by this
The common cnidium fruit P.E that invention the method is prepared, remaining component and content are same as Example 1.
Comparative example 9
Comparative example 9 difference from example 1 is that, with commercially available common cnidium fruit P.E and commercially available hardship in composition of raw materials
Conopsea extraction substitutes the common cnidium fruit P.E and shrubby sophora extract that are prepared by the method for the invention, remaining component and contains
It measures same as Example 1.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Effect test:
Test case 1: vaginal mucomembranous irritant test
Test method: tested group 12 groups, 1 group of blank control group are set up, every group of 10 adult healthy Female rabbits, tested group will move
Object is faced upward fixation, and perineum and introitus are exposed, by conduit with the nursing gel of embodiment 1 ~ 3 and comparative example 1 ~ 9 it is wet after it is light
Soft insertion vagina contacts 24 hours with animal vagina mucosa, and blank control group does not give any processing then, after 24 hours
Dead animal takes out entire vagina, observes hyperemia, the oedema reacting phenomenon of topical vaginal tissue, carries out stimulate the reaction evaluation.
Test result: tested group does not find the abnormal responses such as hyperemia, oedema with control group rabbit topical vaginal tissue,
Other symptoms are not found, according to grade scale as defined in GB 27954-2011 " mucosal disinfectant hygienic requirements ", embodiment 1 ~ 3
It is non-stimulated to rabbit vagina mucosal irritation intensity with 1 ~ 9 tested material of comparative example.
The measurement of 2 skin wound repair of test case
Defined evaluation criterion is provided according to GB 27954-2011 " mucosal disinfectant hygienic requirements ", by embodiment 1 ~ 3 and comparison
The gel tested material multiple-contact rabbit that example 1 ~ 9 obtains causes rabbit skin wound repair, to embodiment 1 ~ 3 and comparative example 1 ~ 9
It is 0 that tested material, which calculates resulting every animal average integral daily to the multiple intact skin stimulate the reaction of rabbit, is pierced according to skin
Swash strength grading standard, tested material multiple-contact rabbit causes a rabbit skin vacuum response；It is " viscous to meet GB 27954-2011
The hygienic requirements of film disinfectant " regulation.
Test case 3: the test of fungistatic effect
The gel obtained according to evaluation criterion as defined in GB 15979-2002 appendix C 4, detection embodiment 1 ~ 3 and comparative example 1 ~ 9
To staphylococcus aureus, Escherichia coli, Candida albicans fungistatic effect, evaluation criterion are as follows: when bacteriostasis rate > 90%, product has
There is bacteriostasis.Specific fungistatic effect is shown in Table 1.
The different fungistatic effects for organizing other gel of table 1
Test case 1 and test case 2 show embodiment 1 ~ 3 and the resulting nursing gel of comparative example 1 ~ 9 to rabbit vagina mucous membrane without
Stimulation, to family's rabbit skin also equal vacuum response.
About fungistatic effect, as seen from the data in Table 1, embodiment 1 is best-of-breed technology scheme, the antibacterial effect of gained nursing gel
Fruit is best；By embodiment 1 from embodiment 2 ~ 3 as it can be seen that gained nursing is solidifying if the preparation parameter during preparing nursing gel is different
The fungistatic effect of glue can be slightly poorer to embodiment 1；It can be seen that from embodiment 1 and comparative example 1 ~ 3, if only adding fowler in composition of raw materials
Any one in alkene, shrubby sophora extract and common cnidium fruit P.E, the fungistatic effect of gained nursing gel will be greatly reduced, wherein
When only adding fullerene, the fungistatic effect of resulting nursing gel is better than only addition shrubby sophora extract or only adds frutus cnidii
The case where extract；By the comparative example of embodiment 1 and comparative example 4 ~ 6 as it can be seen that if only adding fullerene in composition of raw materials, kuh-seng mentions
Any two kinds in object and common cnidium fruit P.E are taken, the fungistatic effect of gained nursing gel can also be declined, wherein work as raw material
Fungistatic effect when in formula containing fullerene can be more preferable；From the comparison of embodiment 1 and comparative example 7 ~ 9 as it can be seen that if matching in raw material
The snake being prepared by the method for the invention is substituted with commercially available common cnidium fruit P.E or commercially available shrubby sophora extract in side
Machine tool extract or shrubby sophora extract, the fungistatic effect of gained nursing gel can not reach the fungistatic effect of embodiment 1.
Claims (10)
1. a kind of for preventing and treating the antibacterial secret nursing gel of gynecological disease, which is characterized in that described resists antibacterial secret to nurse
Gel includes following weight percent raw material: water 86.0 ~ 90.0%, Acritamer 940 0.3 ~ 0.5%, glycerol 3.0 ~ 5.0%, fourth two
Alcohol 3.0 ~ 5.0%, allantoin 0.1 ~ 0.2%, methyl hydroxybenzoate 0.1 ~ 0.2%, collargol 0.5 ~ 1.5%, chlorhexidine gluconate 0.05 ~
0.15%, chlorhexidine acetate 0.05 ~ 0.15%, borneol 0.02 ~ 0.15%, shrubby sophora extract 0.2 ~ 3.0%, common cnidium fruit P.E 0.2 ~
3.0%, chitosan 0.05 ~ 3.0%, triethanolamine 0.3 ~ 0.5%, fuller olefinic carbon 60 .02 ~ 0.2%, polyquaternium -37 1.5 ~ 2.5%, 1,
2- hexylene glycol 0.1 ~ 0.2%, Phenoxyethanol 0.09 ~ 0.2%, Sensiva SC50 0.03 ~ 0.1%, PEG-40 rilanit special 0.1
~ 0.3%, menthol 0.01 ~ 0.05%.
2. according to claim 1 for preventing and treating the antibacterial secret nursing gel of gynecological disease, which is characterized in that described
Resisting antibacterial secret nursing gel includes following weight percent raw material: water 86.12%, Acritamer 940 0.4%, glycerol 3.3%, fourth
Glycol 3.4%, allantoin 0.15%, methyl hydroxybenzoate 0.15%, collargol 1%, chlorhexidine gluconate 0.1%, chlorhexidine acetate
0.1%, borneol 0.06%, shrubby sophora extract 1%, common cnidium fruit P.E 1%, chitosan 0.2%, triethanolamine 0.4%, fullerene
0.08%, polyquaternium -37 2%, 1,2- hexylene glycol 0.15%, Phenoxyethanol 0.12%, Sensiva SC50 0.05%, PEG-40
Rilanit special 0.2%, menthol 0.02%.
3. according to claim 1 for preventing and treating the antibacterial secret nursing gel of gynecological disease, which is characterized in that the hardship
Conopsea extraction is prepared by the inclusion of the method for following steps:
A, kuh-seng is selected, shaking weeds out except impurity, be broken into kuh-seng powder；
B, after soaking broken kuh-seng with 2 ~ 3 times of amount water, 90 ~ 100 DEG C of hot water for being continuously added into 20 ~ 25 times of amounts are continuously inverse
Stream extract 1 ~ 2h, collect extracting solution, kuh-seng residue is then exhausted from after squeezing recovery section liquid, the partially liq of recycling with mention
Liquid is taken to merge；The input speed of the kuh-seng powder is 90 ~ 110kg/h, and the reverse flow velocity that hot water is added is 1800 ~ 2200L/h；
C, the extracting solution after merging filters after being cooled to 70 ~ 75 DEG C, and filtrate sterilizes 12 ~ 14 seconds at 155 ~ 160 DEG C, then 63 ~
It is concentrated under reduced pressure at 65 DEG C, it is dry at 75 DEG C ~ 83 DEG C, obtain shrubby sophora extract.
4. according to claim 1 for preventing and treating the antibacterial secret nursing gel of gynecological disease, which is characterized in that the snake
Machine tool extract is prepared by the inclusion of the method for following steps:
Dry frutus cnidii is taken, the mass fraction that 12 ~ 18 times of its weight amounts are added after crushing is 10 ~ 15% sodium chloride solutions, is impregnated
60 ~ 80min, 6 ~ 9min of microwave treatment under the power of 600 ~ 750W, then 4 ~ 5h of steam distillation is carried out, distillate is collected, i.e.,
Obtain common cnidium fruit P.E.
5. according to claim 1 for preventing and treating the preparation method of the antibacterial secret nursing gel of gynecological disease, feature
It is, is prepared by the inclusion of the method for following steps:
(1) it weighs required water, Acritamer 940, glycerol, allantoin, methyl hydroxybenzoate, chitosan to be added in emulsifier unit, heating
To 83 ~ 85 DEG C, the stirring of 18 ~ 30r/min speed and homogeneous 2 ~ 5 minutes, then constant temperature 10 ~ 20 minutes；
(2) it weighs triethanolamine to be added in emulsifier unit, the stirring of 15 ~ 25 r/min speed is evacuated to -0.05 ~ -0.01Mpa；
(3) butanediol, chlorhexidine acetate, borneol, menthol are weighed in a reservoir and to be heated to 75 ~ 78 DEG C of dissolutions transparent, then plus
Enter PEG-40 rilanit special, is added in emulsifier unit by the raw material dissolved in container, the stirring of 17 ~ 23r/min speed,
It is evacuated to -0.06 ~ -0.02Mpa, begins to cool cooling；
(4) 25 ~ 45 DEG C are cooled to, chlorhexidine gluconate is weighed respectively, shrubby sophora extract, common cnidium fruit P.E, fullerene, gathers
Quaternary ammonium salt -37, collargol are added 15 ~ 25r/min speed in emulsifier unit and stir 12 ~ 18 minutes；
(5) 1,2- hexylene glycol, Phenoxyethanol, Sensiva SC50 are weighed to be uniformly mixed, is added in emulsifier unit, 17 ~ 27r/min
Speed stirs 18 ~ 24 minutes to clear gel, after conventional physical and chemical inspection to obtain the final product.
6. according to claim 5 for preventing and treating the preparation method of the antibacterial secret nursing gel of gynecological disease, feature
It is, the temperature after step (1) described heating is 83 ~ 85 DEG C；The speed of stirring is 18 ~ 30r/min；Homogenizing time is 2 ~ 5 points
Clock；Constant temperature time is 10 ~ 20 minutes.
7. according to claim 5 for preventing and treating the preparation method of the antibacterial secret nursing gel of gynecological disease, feature
It is, the speed of step (2) described stirring is 15 ~ 25 r/min；Pressure after vacuumizing is -0.05 ~ -0.01Mpa.
8. according to claim 5 for preventing and treating the preparation method of the antibacterial secret nursing gel of gynecological disease, feature
It is, the temperature after step (3) described heating is 75 ~ 78 DEG C；The speed of stirring is 17 ~ 23r/min；Pressure after vacuumizing
For -0.06 ~ -0.02Mpa.
9. according to claim 5 for preventing and treating the preparation method of the antibacterial secret nursing gel of gynecological disease, feature
It is, the temperature after step (4) described cooling is 25 ~ 45 DEG C；The speed of stirring be 15 ~ 25r/min, 12 ~ 18 points of mixing time
Clock.
10. according to claim 5 for preventing and treating the preparation method of the antibacterial secret nursing gel of gynecological disease, feature
It is, the speed of step (5) described stirring is 17 ~ 27r/min, and mixing time is 18 ~ 24 minutes.
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| CN110974935A (en) * | 2019-11-26 | 2020-04-10 | 常州市汴禧商贸集团有限公司 | Antibacterial nursing gel containing fullerene C60 component and preparation method thereof |
| CN111700943A (en) * | 2020-05-27 | 2020-09-25 | 佰氏健康(广州)大健康科技有限公司 | Vagina contracting nursing gel and preparation method thereof |
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| CN113230205A (en) * | 2021-05-22 | 2021-08-10 | 绍兴鸿瑞生物科技有限公司 | Gynecological gel preparation and preparation method and application thereof |
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| CN111714421B (en) * | 2020-07-17 | 2023-06-23 | 西安贝迪斯可生物科技有限公司 | Fullerene maintenance antibacterial gel and preparation method thereof |
| CN112675022A (en) * | 2020-12-29 | 2021-04-20 | 陕西善美生物药业有限公司 | Female pudendum care solution and preparation and use method thereof |
| CN113230205A (en) * | 2021-05-22 | 2021-08-10 | 绍兴鸿瑞生物科技有限公司 | Gynecological gel preparation and preparation method and application thereof |
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