CN1562170A - 'Mikang' gels of Chinese traditional medicine for curing inflammation of cervical erosion etc. and preparation method - Google Patents
'Mikang' gels of Chinese traditional medicine for curing inflammation of cervical erosion etc. and preparation method Download PDFInfo
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- CN1562170A CN1562170A CN 200410021434 CN200410021434A CN1562170A CN 1562170 A CN1562170 A CN 1562170A CN 200410021434 CN200410021434 CN 200410021434 CN 200410021434 A CN200410021434 A CN 200410021434A CN 1562170 A CN1562170 A CN 1562170A
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Abstract
A Chinese medicine in the form of gel, ointment, or suppository for treating cervical erosion, cervicities, and vaginitis is prepared from flavescent sophora root, cnidium fruit and pharmacologically acceptable matrix through extracting, dissolving, mixing with carbomer solution or said matrix, dispersing, and regulating pH=2-12.
Description
Technical field:
The present invention relates to medical technical field, exactly it is a kind of rotten sport gel agent of Chinese medicine and compositions and preparation method for the treatment of cervicitises such as cervical erosion.
Background technology:
Cervicitis is present modal gynaecopathia, wherein is main performance with cervical erosion.Cervical erosion pathological changes position is at the columnar epithelium place of cervical canal inner membrance, and general pharmaceutical preparation is difficult to act on this.According to the Epidemiological study result of 15 provinces, autonomous regions and municipalities in the whole nation of sanitation Ministry tissue in 2000, be first that the cervicitis of main performance accounts for present China gynaecopathia with cervical erosion, sickness rate is married woman's 28.9%.To the medicine of cervicitises such as treatment cervical erosion etc. seldom, till 2000, the medicine that is used for the treatment of this disease of state approval has:
Western medicine: have only berberine tannate film (94) to defend the accurate word X-208 of medicine number
Chinese medicine: Fimbriate orostachys herb suppository (the accurate word Z19990053 of traditional Chinese medicines)
Anti-cervicitis capsule (the accurate word Z19990054 of traditional Chinese medicines)
The safe bolt (the accurate word 1999Z-114 of traditional Chinese medicines) of cervix uteri
Protect the FUKANG foam: (98) are defended the accurate word Z-66 of medicine number etc.
At present the medicine of cervicitises such as treatment cervical erosion is in the majority with suppository, but this dosage form performance drug effect is relatively slow and medicine will become liquid after dissolving and flow out vagina, and action time is short.And this dosage form of gel is used for the treatment of cervical lesions and does not still have this drug form, so the rotten sport gel agent of Chinese medicine has vast market prospect.The invention of this gruel sport gel agent provides a kind of new Chinese medicine again for the Chinese traditional treatment gynaecopathia.
Summary of the invention:
The purpose of this invention is to provide a kind of rotten sport gel agent of Chinese medicine and compositions and preparation method for the treatment of cervicitises such as cervical erosion, it isolates multiple chemical compound with effective Chinese herbal medicine of clinical practice, use physico-chemical method and determine structure, part of compounds and total extract thereof after antiinflammatory, antibiotic screening experiment are determined effective site, are made the new medicine gel of a kind of bioavailability height, drug treating time is long, toxic and side effects is little cervicitises such as treatment cervical erosion.This kind dosage form be with drug packages in the container that is similar to syringe, transvaginal is injected in the diseased region at endocorvix place.Drug gel is covered in lesion by itself viscosity and film forming characteristics, has prolonged medicine in the intravaginal holdup time, and has given full play to drug effect.It is to serve as rotten sport gel agent and the compositions thereof that the main extracts of totally two flavor Chinese medicines are made with Fructus Cnidii and Radix Sophorae Flavescentis, and component and content are by weight percentage in the composite formula: Fructus cnidii extract 1-70%, Radix Sophorae Flavescentis extract 2-80%.Also comprise pharmaceutically acceptable substrate, solubilizing agent, wetting agent and adjuvant in the prescription.Described adjuvant is carbomer, mannitol, glucose, lactose, dextrin, starch, Icing Sugar, tween, glycerol, F68, PEG, SDS, EDTA-2Na, propylene glycol, ethyl acetate, ethanol, triethylamine etc.The compositions of the rotten sport gel agent of Chinese medicine can be prepared into pharmaceutical dosage forms such as gel, ointment, suppository, powder needle injection, water needle injection, capsule, soft capsule, tablet, dispersible tablet, electuary, granule, oral liquid.Its preparation method is: Fructus cnidii extract and Radix Sophorae Flavescentis extract are dissolved earlier with solvent and solubilizing agent, adding the earlier scattered carbomer of an amount of water more maybe can be as in the adjuvant of gel-type vehicle, homodisperse, regulate pH value 2.0～12.0 with reagent such as triethylamines, make rotten sport gel agent with cervicitises such as treatment cervical erosion.
Advantage of the present invention is: Fructus Cnidii and Radix Sophorae Flavescentis two flavor Chinese medicines share, common performance detoxifcation is dried, the effect of killing parasites for relieving itching, putrefaction-removing granulation-promoting, be used for the treatment of diseases such as cervicitis, trichomonal vaginitis, colpitis mycotica, nonspecific vaginitis, senile vaginitis, gonorrhea diplococcus infection such as cervical erosion and see above disease person, the invention of the rotten sport gel agent of this Chinese medicine provides a kind of new Chinese medicine again for the Chinese traditional treatment gynaecopathia.
The specific embodiment:
The preparation method of the rotten sport gel agent of Chinese medicine is as follows:
(1) with 1 gram: the ratio of 10～100ml with carbomer be scattered in the water place spend the night standby.
(2) get Radix Sophorae Flavescentis extract 2～10 grams and use water dissolution, add EDTA-2Na0.01～1 gram again, standby.
(3) get Fructus cnidii extract 1～10 gram, add tween 80 0.01～10 gram, grind well, add dehydrated alcohol again, disperse to grind well, add propylene glycol at last and grind well, standby.
(4) Fructus cnidii extract (3) for preparing is added in the scattered carbomers (1) of 10～100 grams and grind evenly, the Radix Sophorae Flavescentis extract (2) for preparing is added wherein continue to grind evenly again, add suitable quantity of water, promptly.
The preparation method of Fructus cnidii extract: the Fructus Cnidii medical material is put in the extraction vessel, for the first time with 1% (w/v) sodium hydrate aqueous solutions of 10 times of amounts, soaked into 10 minutes, and be heated to boiling then, cut boil 30 minutes after, filter with silk immediately, 1% (w/v) sodium hydrate aqueous solution of 8 times of amounts of filtering residue reuse carries out the second time and extracts, and decocts after 30 minutes, filters with silk immediately, merge twice filtrate and add 20% aqueous hydrochloric acid solution that has prepared at once, the limit edged constantly stirs, and transfers pH to 3～4, places 1 hour, separate out drabon color precipitate, centrifugal with 2500r/min then, the supernatant of inclining, precipitate is washed till neutrality with distilled water, centrifugal with 2500r/min again, the supernatant of inclining, the collecting precipitation thing is in forced air drying below 50 ℃ (or lyophilization), weigh, promptly.
The preparation method of Radix Sophorae Flavescentis extract: get the Radix Sophorae Flavescentis medical material, be ground into coarse powder, by " under appendix IO fluid extract of Chinese pharmacopoeia (version in 2000) and the extractum item, percolation is carried out in the requirement of the main points of percolation, and the percolation solvent is 0.1% hydrochloric acid.Percolate after exchange finishes, in resin impouring container, is washed with water to the clarification of water liquid by cation exchange resin column, drains, and resin is put in the dish air-dry again.It is an amount of that air-dry back resin adds strong aqua ammonia, mixes thoroughly, and vexed putting 30 minutes makes alkalization fully, waves unnecessary to the greatest extent ammonia, in the apparatus,Soxhlet's of packing into, uses chloroform reflux, extract, 3 hours.Chloroform extracted solution adds anhydrous sodium sulfate and dewaters, and stirs the back and places 30 minutes, and filtration is reclaimed chloroform and done near, and adding acetone-ether (1: 1) mixed solvent is a small amount of, places crystallize.Separate out coarse-grain and put in the sintered filter funnel (G3), with the washing of small amount of acetone-ether mixed solvent for several times, sucking filtration in 60 ℃ of vacuum dryings 2 hours, promptly gets Radix Sophorae Flavescentis extract then.
Embodiment:
The rotten sport gel agent of 1 Chinese medicine
Prescription: Fructus cnidii extract 150g
Radix Sophorae Flavescentis extract 300g
Carbomer 125g
Make 1000 of gels
Method for making:, press the preparation method preparation of gel, promptly with recipe quantity extract and adjuvant.
The rotten recovering capsule agent of 2 Chinese medicines
Prescription: Fructus cnidii extract 200g
Radix Sophorae Flavescentis extract 300g
Mannitol 300g
Incapsulate 1000
Method for making: with recipe quantity extract and proppant mannitol, mixing incapsulates promptly.
The rotten health tablet of 3 Chinese medicines
Prescription: Fructus cnidii extract 200g
Radix Sophorae Flavescentis extract 100g
Mannitol 300g
Make 1000
Method for making: with recipe quantity extract and proppant mannitol, mixing, wet granulation, wet grain is in 60～80 ℃ of dryings.Dried granule is carried out adding the moderate lubrication agent and being pressed into 1000 after granulate handles, coating, promptly.
The rotten health electuary of 4 Chinese medicines
Prescription: Fructus cnidii extract 100g
Radix Sophorae Flavescentis extract 250g
Icing Sugar 500g
Make 1000 bags
Method for making: with recipe quantity extract and proppant Icing Sugar, mixing, wet granulation, wet grain is in 60～80 ℃ of dryings.Dried granule is carried out adorning 1000 bags, promptly after granulate handles.
The rotten recovery oral liquid of 5 Chinese medicines
Prescription: Fructus cnidii extract 200g
Radix Sophorae Flavescentis extract 350g
Mannitol 10.0g
Make 1000ml
Method for making: with recipe quantity extract and proppant mannitol, add suitable quantity of water, heating for dissolving filters, and adds simple syrup, and benzyl alcohol sodium adds an amount of water again to 1000ml, and cold preservation is filtered, and is packaged in the 10ml peace bottle, with 100 ℃ of sterilizations 30 minutes, promptly.
Claims (6)
1, treats the rotten sport gel agent of Chinese medicine of inflammation such as cervical erosion, it is characterized in that: contain Chinese medicine Fructus Cnidii and Radix Sophorae Flavescentis in the rotten sport gel agent of Chinese medicine, be used to prepare the medicine of gynaecopathias such as cervicitis, trichomonal vaginitis, colpitis mycotica, nonspecific vaginitis, senile vaginitis, gonorrhea diplococcus infection such as treatment cervical erosion.
2, the rotten sport gel agent of the Chinese medicine of inflammation such as treatment cervical erosion according to claim 1, it is characterized in that: described Fructus Cnidii and Radix Sophorae Flavescentis are Fructus cnidii extract and Radix Sophorae Flavescentis extract.
3, the compositions of the rotten sport gel agent of the Chinese medicine of inflammation such as a kind of treatment cervical erosion as claimed in claim 1, it is characterized in that: component and content are by weight percentage in the composite formula: Fructus cnidii extract 1-70%, Radix Sophorae Flavescentis extract 2-80%, surplus is pharmaceutically acceptable substrate, solubilizing agent, wetting agent and adjuvant.
4, the compositions of the rotten sport gel agent of the Chinese medicine of inflammation such as treatment cervical erosion according to claim 3, it is characterized in that: described adjuvant is carbomer, mannitol, glucose, lactose, dextrin, starch, Icing Sugar, tween, glycerol, F68, PEG, SDS, EDTA-2Na, propylene glycol, ethyl acetate, ethanol, triethylamine etc.
5, the compositions of the rotten sport gel agent of the Chinese medicine of inflammation such as treatment cervical erosion according to claim 3 is characterized in that: the compositions of the rotten sport gel agent of Chinese medicine can be prepared into pharmaceutical dosage forms such as gel, ointment, suppository, powder needle injection, water needle injection, capsule, soft capsule, tablet, dispersible tablet, electuary, granule, oral liquid.
6, the preparation method of the rotten sport gel agent of the Chinese medicine of inflammation such as a kind of treatment cervical erosion as claimed in claim 1, it is characterized in that: Fructus cnidii extract and Radix Sophorae Flavescentis extract are dissolved earlier with solvent and solubilizing agent, adding the earlier scattered carbomer of an amount of water more maybe can be as in the adjuvant of gel-type vehicle, homodisperse, regulate pH value 2.0～12.0 with reagent such as triethylamines, make gelatinous rotten sport gel agent.
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| CN200410021434A CN100574774C (en) | 2004-03-22 | 2004-03-22 | The rotten sport gel agent of Chinese medicine and the preparation method of inflammation such as treatment cervical erosion |
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| CN200410021434A CN100574774C (en) | 2004-03-22 | 2004-03-22 | The rotten sport gel agent of Chinese medicine and the preparation method of inflammation such as treatment cervical erosion |
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| CN1562170A true CN1562170A (en) | 2005-01-12 |
| CN100574774C CN100574774C (en) | 2009-12-30 |
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Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103845615A (en) * | 2014-03-24 | 2014-06-11 | 李周全 | Pharmaceutical composition for treating vaginitis |
| CN104606598A (en) * | 2015-02-15 | 2015-05-13 | 沈阳盛达科医药科技有限公司 | Golden cypress anti-erosion lotion and preparation method thereof |
| CN104983983A (en) * | 2015-08-03 | 2015-10-21 | 买海涛 | Traditional Chinese medicine composition for treating gynecological disease and preparation thereof |
| CN106491912A (en) * | 2016-11-24 | 2017-03-15 | 东莞市乐堂医疗投资有限公司 | A kind of treat Chinese medicine external gel of colpitis and preparation method thereof |
| CN106581172A (en) * | 2017-02-13 | 2017-04-26 | 陈耕 | Medicine used for preventing and treating mycotic, trichomonas and senile vaginitis and preparation method thereof |
| CN107213177A (en) * | 2017-06-15 | 2017-09-29 | 陕西海天制药有限公司 | A kind of preparation method for the Chinese medicine composition and its gel for treating cervical erosion |
| CN107913301A (en) * | 2017-11-15 | 2018-04-17 | 中政道和（北京）生物科技有限公司 | A kind of Essence of the Chinese medicine composition conserved for women privates and its extract containing said composition |
| CN108159123A (en) * | 2018-01-25 | 2018-06-15 | 成都山信药业有限公司 | A kind of pharmaceutical composition for treating female genital tract infection and preparation method thereof |
| CN108524601A (en) * | 2018-05-22 | 2018-09-14 | 北京恒峰昊瑞生物科技有限公司 | A kind of vaginal jellies and preparation method thereof containing pleiotrophic factor |
| CN108938721A (en) * | 2018-09-18 | 2018-12-07 | 右江民族医学院 | It is a kind of to treat vaginitis, compound Chinese medicinal preparation of Dermatology and preparation method thereof |
| CN109620798A (en) * | 2019-01-18 | 2019-04-16 | 黄斌斌 | It is a kind of to resist antibacterial secret nursing gel for anti-gynecological disease |
| CN110664934A (en) * | 2019-09-12 | 2020-01-10 | 刘敏如女科医系研究院(深圳)有限公司 | Antibacterial and antipruritic traditional Chinese medicine composition and preparation method and application thereof |
| CN111000890A (en) * | 2019-12-30 | 2020-04-14 | 重庆宫妙生物科技有限公司 | Gel dressing for preventing and inhibiting HPV virus infection and preparation method thereof |
| CN111643545A (en) * | 2020-07-30 | 2020-09-11 | 欧迪玛(湖北)生物科技有限公司 | Gel composition for treating cervical erosion and preparation method thereof |
| CN111700958A (en) * | 2020-07-27 | 2020-09-25 | 孙芬 | Gel bacteriostatic preparation |
| CN113244357A (en) * | 2021-05-31 | 2021-08-13 | 中国药科大学 | Micro-emulsion gel of anti-HPV plant extract and preparation method and application thereof |
-
2004
- 2004-03-22 CN CN200410021434A patent/CN100574774C/en not_active Expired - Fee Related
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103845615B (en) * | 2014-03-24 | 2016-03-30 | 李周全 | One treats colpitic pharmaceutical composition |
| CN103845615A (en) * | 2014-03-24 | 2014-06-11 | 李周全 | Pharmaceutical composition for treating vaginitis |
| CN104606598B (en) * | 2015-02-15 | 2017-12-22 | 沈阳盛达科医药科技有限公司 | Cypress gruel elimination detergent and preparation method thereof |
| CN104606598A (en) * | 2015-02-15 | 2015-05-13 | 沈阳盛达科医药科技有限公司 | Golden cypress anti-erosion lotion and preparation method thereof |
| CN104983983A (en) * | 2015-08-03 | 2015-10-21 | 买海涛 | Traditional Chinese medicine composition for treating gynecological disease and preparation thereof |
| CN106491912A (en) * | 2016-11-24 | 2017-03-15 | 东莞市乐堂医疗投资有限公司 | A kind of treat Chinese medicine external gel of colpitis and preparation method thereof |
| CN106581172B (en) * | 2017-02-13 | 2020-09-04 | 湖北精耕生物工程有限公司 | Medicine for preventing and treating mycotic vaginitis, trichomonas vaginitis and senile vaginitis and preparation method thereof |
| CN106581172A (en) * | 2017-02-13 | 2017-04-26 | 陈耕 | Medicine used for preventing and treating mycotic, trichomonas and senile vaginitis and preparation method thereof |
| CN107213177A (en) * | 2017-06-15 | 2017-09-29 | 陕西海天制药有限公司 | A kind of preparation method for the Chinese medicine composition and its gel for treating cervical erosion |
| CN107913301A (en) * | 2017-11-15 | 2018-04-17 | 中政道和（北京）生物科技有限公司 | A kind of Essence of the Chinese medicine composition conserved for women privates and its extract containing said composition |
| CN108159123A (en) * | 2018-01-25 | 2018-06-15 | 成都山信药业有限公司 | A kind of pharmaceutical composition for treating female genital tract infection and preparation method thereof |
| CN108524601A (en) * | 2018-05-22 | 2018-09-14 | 北京恒峰昊瑞生物科技有限公司 | A kind of vaginal jellies and preparation method thereof containing pleiotrophic factor |
| CN108524601B (en) * | 2018-05-22 | 2021-05-04 | 北京恒峰铭成生物科技有限公司 | Vaginal gel containing pleiotropic factors and preparation method thereof |
| CN108938721A (en) * | 2018-09-18 | 2018-12-07 | 右江民族医学院 | It is a kind of to treat vaginitis, compound Chinese medicinal preparation of Dermatology and preparation method thereof |
| CN109620798A (en) * | 2019-01-18 | 2019-04-16 | 黄斌斌 | It is a kind of to resist antibacterial secret nursing gel for anti-gynecological disease |
| CN110664934A (en) * | 2019-09-12 | 2020-01-10 | 刘敏如女科医系研究院(深圳)有限公司 | Antibacterial and antipruritic traditional Chinese medicine composition and preparation method and application thereof |
| CN111000890A (en) * | 2019-12-30 | 2020-04-14 | 重庆宫妙生物科技有限公司 | Gel dressing for preventing and inhibiting HPV virus infection and preparation method thereof |
| CN111700958A (en) * | 2020-07-27 | 2020-09-25 | 孙芬 | Gel bacteriostatic preparation |
| CN111643545A (en) * | 2020-07-30 | 2020-09-11 | 欧迪玛(湖北)生物科技有限公司 | Gel composition for treating cervical erosion and preparation method thereof |
| CN113244357A (en) * | 2021-05-31 | 2021-08-13 | 中国药科大学 | Micro-emulsion gel of anti-HPV plant extract and preparation method and application thereof |
| CN113244357B (en) * | 2021-05-31 | 2022-07-29 | 中国药科大学 | Micro-emulsion gel of anti-HPV plant extract and preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN100574774C (en) | 2009-12-30 |
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