CN110624062A - Efficient stable antibacterial powder and preparation method thereof - Google Patents

Efficient stable antibacterial powder and preparation method thereof Download PDF

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Publication number
CN110624062A
CN110624062A CN201911062388.7A CN201911062388A CN110624062A CN 110624062 A CN110624062 A CN 110624062A CN 201911062388 A CN201911062388 A CN 201911062388A CN 110624062 A CN110624062 A CN 110624062A
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parts
bacteriostatic
weight
stable
powder
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曾严红
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Benguan Biotechnology (shanghai) Co Ltd
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Benguan Biotechnology (shanghai) Co Ltd
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract

The invention discloses efficient and stable antibacterial powder and a preparation method thereof, relates to the technical field of sanitary products, and solves the problem of poor integral application effect of antibacterial products due to poor antibacterial stability of the antibacterial products. An efficient stable antibacterial powder comprises the following components in parts by weight: 14-30 parts of a bacteriostatic composition; 0.8-1.6 parts of carbomer; 1-4 parts of carboxymethyl chitosan; 0.2-0.6 part of pH regulator; 0.1-0.5 part of lubricant; 7-13 parts of ethanol; 3-10 parts of pure water; tween 800.3-1.5 parts; 0.5-0.9 part of propolis; 1.1-1.5 parts of bamboo vinegar; 0.2-0.8 part of chlorhexidine acetate. The efficient and stable antibacterial powder has good antibacterial stability in the actual use process, can exert good antibacterial effect, and has good applicability as a whole.

Description

Efficient stable antibacterial powder and preparation method thereof
Technical Field
The invention relates to the technical field of hygienic products, in particular to efficient and stable antibacterial powder and a preparation method thereof.
Background
The gynecological inflammation is mainly caused by physiological pollution, physical injury, chemical stimulation and biological infection. The biogenic infection refers to infection of female genital tract with various pathogenic bacteria, such as Candida albicans, Staphylococcus aureus or Escherichia coli, and breaks the balance system of flora, so that its cleaning function is damaged, and inflammation is caused.
In the Chinese invention patent application with the publication number of CN108014287A, an effervescent bacteriostatic tablet is disclosed, which comprises the following components; chlorhexidine acetate, citric acid, sodium bicarbonate, lactobacillus powder, radix Sophorae Flavescentis powder, radix Stemonae powder, fructus Cnidii powder, Carthami flos powder, cortex Phellodendri powder, Aloe powder, TM600 (lubricant), Chinese medicinal odor type and water. The preparation method comprises the following steps; step one; adding chlorhexidine acetate, citric acid, sodium bicarbonate, lactobacillus powder, radix Sophorae Flavescentis powder, radix Stemonae powder, fructus Cnidii powder, Carthami flos powder, cortex Phellodendri powder, Aloe powder, TM600 (lubricant) and Chinese medicinal incense into the water, and stirring to make the content distribution uniform; step two; and (2) performing solid forming on the mixture of chlorhexidine acetate, citric acid, sodium bicarbonate, lactobacillus powder, radix sophorae flavescentis powder, radix stemonae powder, fructus cnidii powder, safflower powder, cortex phellodendri powder, aloe powder, TM600 (lubricant), traditional Chinese medicine odor type and water.
In the above application, the solid bacteriostatic tablets formed by mixing the component raw materials can kill germs and obviously improve the bactericidal and bacteriostatic effects, so that the solid bacteriostatic tablets can effectively inhibit the growth of germs, reduce the invasion of germs, protect the vagina of women and achieve the purpose of bacteriostasis and antibiosis.
Disclosure of Invention
Aiming at the problem that the whole application effect of a bacteriostatic product is poor due to poor bacteriostatic stability of the bacteriostatic product in the prior art, the invention aims to provide the high-efficiency stable bacteriostatic powder to solve the technical problem, and the bacteriostatic powder has good bacteriostatic stability, can exert good bacteriostatic effect and has good application property.
In order to achieve the first purpose, the invention provides the following technical scheme:
an efficient stable antibacterial powder comprises the following components in parts by weight:
14-30 parts of a bacteriostatic composition;
0.8-1.6 parts of carbomer;
1-4 parts of carboxymethyl chitosan;
0.2-0.6 part of pH regulator;
0.1-0.5 part of lubricant;
7-13 parts of ethanol;
3-10 parts of pure water;
tween 800.3-1.5 parts;
0.5-0.9 part of propolis;
1.1-1.5 parts of bamboo vinegar;
0.2-0.8 part of chlorhexidine acetate.
By adopting the technical scheme, the antibacterial composition is composed of natural antibacterial traditional Chinese medicines, can form a water-soluble complex with carbomer, and can exert a good antibacterial effect. The carboxymethyl chitosan is a water-soluble chitosan derivative, has good antibacterial property and good medical care effect, and particularly has remarkable anti-tumor effect. Tween 80 is a good surfactant, and is beneficial to ensuring that the raw materials of all components play a role fully, so that the high-efficiency stable antibacterial powder has good quality. Chlorhexidine acetate is a high-efficiency safe antibacterial disinfectant, can kill staphylococcus aureus, escherichia coli and candida albicans, and achieves the purposes of bacteriostasis and antibiosis.
The propolis extract has strong bacteriostatic activity, has good stability on heat treatment, pH value, ultraviolet rays and metal ions, and plays a good role in protecting the bacteriostatic composition, thereby ensuring that the high-efficiency stable bacteriostatic powder has good bacteriostatic stability in the using process. The bamboo vinegar has broad-spectrum antibacterial property, good antibacterial activity and antibacterial stability, and can play a good compounding synergistic effect with propolis, so that the activity of active ingredients in the high-efficiency stable antibacterial powder is easily influenced by external factors, a good antibacterial effect can be exerted in the using process, and the high-efficiency stable antibacterial powder has good applicability as a whole.
More preferably, the bacteriostatic composition is prepared by mixing the following components in parts by weight:
1-3 parts of sophora flavescens;
1.5-3 parts of giant knotweed;
3-6 parts of oldenlandia diffusa;
2-3 parts of phellodendron;
1.5-2.5 parts of fructus cnidii;
2-5 parts of sea clams;
1-4 parts of dragon's blood;
0.5-1.5 parts of borneol;
1.5-2 parts of fructus kochiae.
By adopting the technical scheme, the bacteriostatic composition consisting of the traditional Chinese medicine components has no side effect on a human body, can eliminate toxic substances damaging organism cells, enhances the disease resistance of the human body, has the efficacies of bacteriostasis, diminishing inflammation, scavenging free radicals, scavenging toxins and the like, especially has stronger inhibiting effect on escherichia coli, staphylococcus aureus and candida albicans, and can protect the vagina of a woman and achieve good bacteriostatic and antibacterial effects.
More preferably, 0.1 to 0.3 weight part of spice extracting solution is also added into the components of the high-efficiency stable antibacterial powder.
By adopting the technical scheme, the spice extracting solution has good antibacterial activity, the antibacterial component has strong stability and higher activity, is not easily influenced by external factors, can exert good and stable antibacterial effect in the using process, and further greatly improves the overall quality of the high-efficiency stable antibacterial powder. Meanwhile, the spice extract also has certain pharmacological health-care effect, is beneficial to maintaining the stability of the internal environment of a human body and improving the immunity of the human body.
More preferably, the spice extract is obtained by extracting 8-10 parts by weight of natural spices, and the natural spices are any one or more of mint, cinnamon, fennel and clove.
By adopting the technical scheme, the mint, the cinnamon, the fennel and the clove are light in nature and taste, and are not easy to have a large stimulation effect on the parts of a user, and the natural spice is wide in source and low in cost, so that the applicability of the high-efficiency stable antibacterial powder is ensured. Meanwhile, the mint, the cinnamon, the fennel and the clove also have certain natural fragrance, have a good covering effect on the medicinal taste of the antibacterial composition, and improve the overall quality of the efficient and stable antibacterial powder.
More preferably, the spice extracting solution is obtained by extracting through the following steps:
s1, adding ethanol with the volume fraction of 70% -85% which is 3-5 times that of the natural spice in parts by weight, refluxing and extracting twice, wherein the first refluxing time is 30-50min, the second refluxing time is 20-30min, and then mixing the two refluxing extract solutions to obtain a mixed solution;
s2, putting the mixed solution in a water bath at the temperature of 60-80 ℃, volatilizing until no alcohol smell exists, adding water to adjust the volume until the mass concentration reaches 0.8-1.2g/L, and adjusting the pH value to 7-8 to obtain the spice extracting solution.
By adopting the technical scheme, the extraction process for the natural spices has the advantages that the good extraction effect on active ingredients in the spices is achieved, the extracts are purified in the extraction process, the spicery extracting solution is clean and nontoxic, and the effect is high.
More preferably, 0.5 to 1.3 parts by weight of citral is also added into the components of the high-efficiency stable antibacterial powder.
Through adopting above-mentioned technical scheme, citral has good bacteriostatic action, and its enzymatic activity in the application can be reduced in the bacterial cell wall, and then plays good inhibitory action to the hyperplasia of bacterium, and citral still plays good guard action to the active ingredient in the high-efficient stable antibacterial powder, can maintain its bacteriostatic stable performance, and then makes the quality and the application of high-efficient stable antibacterial powder improve greatly.
More preferably, the pH adjuster is any one of sodium hydroxide, potassium hydroxide, and triethanolamine.
By adopting the technical scheme, the sodium hydroxide, the potassium hydroxide and the triethanolamine can effectively maintain the stability of the high-efficiency stable antibacterial powder system, so that the high-efficiency stable antibacterial powder has good and stable quality as a whole, and a good and stable antibacterial effect can be exerted in the using process.
More preferably, the lubricant is any one of glycerol, propylene glycol and polyethylene glycol.
By adopting the technical scheme, the glycerol, the propylene glycol and the polyethylene glycol are good lubricants, so that the surface of the high-efficiency stable antibacterial powder becomes smooth, the use is more convenient, and the antibacterial powder can quickly act on the use part.
The second purpose of the invention is to provide a preparation method of the high-efficiency stable antibacterial powder, and the high-efficiency stable antibacterial powder prepared by the method has good antibacterial stability, can exert good antibacterial effect and has good application property as a whole.
In order to achieve the second purpose, the invention provides the following technical scheme, which comprises the following steps:
step one, cleaning the bacteriostatic composition according to the corresponding weight part, drying, crushing, extracting by using a percolation method, and concentrating until the relative density is 0.8-1.5 at 50-60 ℃ to obtain a bacteriostatic extract;
step two, adding carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80, propolis, bamboo vinegar and chlorhexidine acetate in required weight parts into the extract, stirring and mixing, and then distilling in a distillation kettle under reduced pressure for 2-3h at the temperature of 80-90 ℃ to obtain slurry;
and step three, adding the pH regulator and the lubricant in corresponding parts by weight into the slurry, fully stirring until the mixture is completely mixed, wherein the stirring speed is 500-800rpm, the stirring time is 20-30min, carrying out low-temperature solidification, and crushing to obtain the high-efficiency stable antibacterial powder.
By adopting the technical scheme, the effective components in the antibacterial composition are extracted firstly, then the obtained antibacterial extract is mixed with other component raw materials, slurry with good antibacterial effect can be obtained, the pH regulator and the lubricant are added at the moment, so that the component raw materials are fully combined, the quality of the slurry is improved, and finally, the slurry is solidified at low temperature and is crushed to obtain the high-efficiency stable antibacterial powder. Meanwhile, the preparation method is simple to operate, high in production efficiency, free of great pollution to the environment and good in applicability in the actual use process.
In summary, compared with the prior art, the invention has the following beneficial effects:
(1) the propolis and the bamboo vinegar can improve the bacteriostatic stability of the whole high-efficiency stable bacteriostatic powder, and when the propolis and the bamboo vinegar are mixed for use, the propolis and the bamboo vinegar can play a good role in compounding and synergism, so that the activity of active ingredients in the high-efficiency stable bacteriostatic powder is easily influenced by external factors, and a good bacteriostatic effect can be exerted in the using process, so that the whole high-efficiency stable bacteriostatic powder has good applicability;
(2) the spice extracting solution is added, so that the bacteriostatic performance of the high-efficiency stable bacteriostatic powder can be greatly improved, the high-efficiency stable bacteriostatic powder can also exert good and stable bacteriostatic effect in the using process, and the overall quality of the high-efficiency stable bacteriostatic powder is further greatly improved;
(3) the citral tool is added, so that the enzymatic activity in bacterial cell walls can be reduced in the application process, the proliferation of bacteria is well inhibited, the citral also has a good protection effect on active ingredients in the high-efficiency stable antibacterial powder, the stable performance of the antibacterial effect can be maintained, and the applicability of the high-efficiency stable antibacterial powder is greatly improved.
Drawings
FIG. 1 is a process flow diagram of the present invention.
Detailed Description
The invention is described in detail below with reference to the figures and examples.
Example 1: the efficient and stable antibacterial powder comprises the components and the corresponding parts by weight shown in Table 1, and is prepared by the following steps:
step one, cleaning the bacteriostatic composition in a corresponding weight part, drying, crushing, extracting by using a percolation method, and concentrating until the relative density is 1.15 at 55 ℃ to obtain a bacteriostatic extract;
step two, adding carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80, propolis, bamboo vinegar and chlorhexidine acetate in required weight parts into the extract, stirring and mixing, and then distilling in a distillation kettle under reduced pressure for 2.5h at the temperature of 85 ℃ to obtain slurry;
and step three, adding triethanolamine and glycerol in corresponding parts by weight into the slurry, fully stirring until the triethanolamine and the glycerol are completely mixed, wherein the stirring speed is 650rpm, the stirring time is 25min, carrying out low-temperature curing, and crushing to obtain the high-efficiency stable antibacterial powder.
Note: the bacteriostatic composition in the step one is prepared by mixing the following components in parts by weight: 2 parts of sophora flavescens; 2.25 parts of giant knotweed; 4.5 parts of oldenlandia; 2.5 parts of phellodendron; 2 parts of fructus cnidii; 3.5 parts of sea clams; 2.5 parts of dragon's blood; 1 part of borneol; 1.75 parts of broom cypress fruit.
Example 2: the high-efficiency stable antibacterial powder is different from the antibacterial powder in the embodiment 1 in that the high-efficiency stable antibacterial powder comprises the following steps:
step one, cleaning the bacteriostatic composition in a corresponding weight part, drying, crushing, extracting by using a percolation method, and concentrating until the relative density is 1.5 at 50 ℃ to obtain a bacteriostatic extract;
step two, adding carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80, propolis, bamboo vinegar and chlorhexidine acetate in required weight parts into the extract, stirring and mixing, and then distilling in a distillation kettle under reduced pressure for 2 hours at the temperature of 90 ℃ to obtain slurry;
and step three, adding triethanolamine and glycerol in corresponding weight parts into the slurry, fully stirring until the triethanolamine and the glycerol are completely mixed, wherein the stirring speed is 500rpm, the stirring time is 30min, carrying out low-temperature curing, and crushing to obtain the high-efficiency stable antibacterial powder.
Example 3: the high-efficiency stable antibacterial powder is different from the antibacterial powder in the embodiment 1 in that the high-efficiency stable antibacterial powder comprises the following steps:
step one, cleaning the bacteriostatic composition in a corresponding weight part, drying, crushing, extracting by using a percolation method, and concentrating until the relative density is 0.8 at 60 ℃ to obtain a bacteriostatic extract;
step two, adding carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80, propolis, bamboo vinegar and chlorhexidine acetate in required weight parts into the extract, stirring and mixing, and then distilling in a distillation kettle under reduced pressure for 3 hours at the temperature of 80 ℃ to obtain slurry;
and step three, adding triethanolamine and glycerol in corresponding parts by weight into the slurry, fully stirring until the triethanolamine and the glycerol are completely mixed, wherein the stirring speed is 800rpm, the stirring time is 20min, carrying out low-temperature curing, and crushing to obtain the high-efficiency stable antibacterial powder.
Examples 4 to 5: the difference between the efficient and stable antibacterial powder and the example 1 is that the components and the corresponding parts by weight are shown in the table 1.
TABLE 1 Components and parts by weight of examples 1-5
Example 6: the difference between the efficient and stable antibacterial powder and the embodiment 1 is that the antibacterial composition in the step one is prepared by mixing the following components in parts by weight: 1 part of sophora flavescens; 1.5 parts of giant knotweed; 3 parts of oldenlandia; 2 parts of phellodendron; 1.5 parts of fructus cnidii; 2 parts of sea clams; 1 part of dragon's blood; 0.5 part of borneol; 1.5 parts of fructus kochiae.
Example 7: the difference between the efficient and stable antibacterial powder and the embodiment 1 is that the antibacterial composition in the step one is prepared by mixing the following components in parts by weight: 3 parts of sophora flavescens; 3 parts of giant knotweed; 6 parts of oldenlandia; 3 parts of phellodendron; 2.5 parts of fructus cnidii; 5 parts of sea clams; 4 parts of dragon's blood; 1.5 parts of borneol; and 2 parts of fructus kochiae.
Example 8: the difference between the efficient and stable antibacterial powder and the embodiment 1 is that triethanolamine in the third step is replaced by sodium hydroxide with equal mass.
Example 9: the difference between the efficient and stable antibacterial powder and the embodiment 1 is that triethanolamine in the third step is replaced by potassium hydroxide with equal mass.
Example 10: the difference between the efficient and stable antibacterial powder and the embodiment 1 is that glycerol in the step three is replaced by propylene glycol with equal mass.
Example 11: the efficient and stable antibacterial powder is different from the antibacterial powder in the embodiment 1 in that glycerol in the step III is replaced by polyethylene glycol with equal mass.
Example 12: the difference between the efficient and stable antibacterial powder and the embodiment 1 is that the step two is specifically set as that carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80, propolis, bamboo vinegar, chlorhexidine acetate and 0.2 part of spice extract are added into the extract in the required weight parts to be stirred and mixed, and then the mixture is subjected to reduced pressure distillation in a distillation kettle for 2.5 hours at the temperature of 85 ℃ to obtain slurry.
Note: the spice extracting solution in the step two is obtained by extracting 9 parts by weight of natural spices, the natural spices are clove, and the natural spices are obtained by the following steps:
s1, adding ethanol with the volume fraction of 77.5 percent which is 4 times that of the natural spice in parts by weight, refluxing and extracting for two times, wherein the first refluxing time is 40min, the second refluxing time is 25min, and then mixing the two refluxing and extracting solutions to obtain a mixed solution;
s2, putting the mixed solution in a water bath at 70 ℃, volatilizing until no alcohol smell exists, adding water to adjust the volume until the mass concentration reaches 1g/L, and adjusting the pH value to 7.5 to obtain the spice extracting solution.
Example 13: the difference between the efficient and stable antibacterial powder and the step two in the embodiment 12 is that carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80, propolis, bamboo vinegar, chlorhexidine acetate and 0.1 part of spice extract are added into the extract in required weight parts to be stirred and mixed, and then the mixture is subjected to reduced pressure distillation in a distillation kettle for 2.5 hours at the temperature of 85 ℃ to obtain slurry.
Example 14: the difference between the efficient and stable antibacterial powder and the step two in the embodiment 12 is that carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80, propolis, bamboo vinegar, chlorhexidine acetate and 0.3 part of spice extract are added into the extract in required weight parts to be stirred and mixed, and then the mixture is subjected to reduced pressure distillation in a distillation kettle for 2.5 hours at the temperature of 85 ℃ to obtain slurry.
Example 15: an efficient and stable antibacterial powder is different from that in example 12 in that a spice extracting solution is obtained by extracting 8 parts by weight of natural spices, namely clove.
Example 16: an efficient and stable antibacterial powder is different from that in example 12 in that a spice extracting solution is extracted from 10 parts by weight of natural spices, wherein the natural spices are clove.
Example 17: an efficient and stable antibacterial powder is different from that in example 12 in that a spice extracting solution is obtained by extracting 9 parts by weight of natural spices, wherein the natural spices are selected from 4 parts by weight of mint and 5 parts by weight of cinnamon.
Example 18: an efficient and stable antibacterial powder is different from the antibacterial powder in example 12 in that a spice extracting solution is obtained by extracting 9 parts by weight of natural spices, wherein the natural spices are 3 parts by weight of cinnamon, 2 parts by weight of fennel and 4 parts by weight of clove.
Example 19: the difference between the efficient and stable antibacterial powder and the antibacterial powder in the embodiment 12 is that the spice extracting solution is obtained by the following steps:
s1, adding 70% ethanol in an amount which is 3 times the volume fraction of the natural spice according to the corresponding weight part, refluxing and extracting for two times, wherein the first refluxing time is 30min, the second refluxing time is 20min, and then mixing the two refluxing extract solutions to obtain a mixed solution;
s2, putting the mixed solution in a water bath at 60 ℃, volatilizing until no alcohol smell exists, adding water to adjust the volume until the mass concentration reaches 0.8g/L, and adjusting the pH value to 7 to obtain the spice extracting solution.
Example 20: the difference between the efficient and stable antibacterial powder and the antibacterial powder in the embodiment 12 is that the spice extracting solution is obtained by the following steps:
s1, adding 85% ethanol in an amount which is 5 times the volume fraction of the natural spice according to the corresponding weight part, refluxing and extracting twice, wherein the first refluxing time is 50min, the second refluxing time is 30min, and then mixing the two refluxing extract solutions to obtain a mixed solution;
s2, putting the mixed solution in a water bath at 80 ℃, volatilizing until no alcohol smell exists, adding water to adjust the volume until the mass concentration reaches 1.2g/L, and adjusting the pH value to 8 to obtain the spice extracting solution.
Example 21: the difference between the efficient and stable antibacterial powder and the embodiment 1 is that the step two is specifically set as that carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80, propolis, bamboo vinegar, chlorhexidine acetate and 0.9 part of citral in the required weight parts are added into the extract to be stirred and mixed, and then the mixture is subjected to reduced pressure distillation in a distillation kettle for 2.5 hours at the temperature of 85 ℃ to obtain slurry.
Example 22: the difference between the efficient and stable antibacterial powder and the embodiment 1 is that the step two is specifically set as that carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80, propolis, bamboo vinegar, chlorhexidine acetate and 0.5 part of citral in the required weight parts are added into the extract to be stirred and mixed, and then the mixture is subjected to reduced pressure distillation in a distillation kettle for 2.5 hours at the temperature of 85 ℃ to obtain slurry.
Example 23: the difference between the efficient and stable antibacterial powder and the embodiment 1 is that the step two is specifically set as that carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80, propolis, bamboo vinegar, chlorhexidine acetate and 1.3 parts of citral in the required weight parts are added into the extract to be stirred and mixed, and then the mixture is subjected to reduced pressure distillation in a distillation kettle for 2.5 hours at the temperature of 85 ℃ to obtain slurry.
Comparative example 1: the difference between the efficient and stable antibacterial powder and the embodiment 1 is that the step two is specifically set as that carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80, propolis and chlorhexidine acetate in the required weight parts are added into the extract to be stirred and mixed, and then the mixture is subjected to reduced pressure distillation in a distillation kettle for 2.5 hours at the temperature of 85 ℃ to obtain slurry.
Comparative example 2: the difference between the efficient and stable antibacterial powder and the embodiment 1 is that the step two is specifically set as that carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80, bamboo vinegar and chlorhexidine acetate in the required weight parts are added into the extract to be stirred and mixed, and then the mixture is distilled in a distillation kettle under reduced pressure for 2.5 hours at the temperature of 85 ℃ to obtain slurry.
Comparative example 3: the difference between the efficient and stable antibacterial powder and the embodiment 1 is that the step two is specifically set as that carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80 and chlorhexidine acetate in the required weight portions are added into the extract to be stirred and mixed, and then the mixture is subjected to reduced pressure distillation in a distillation kettle for 2.5 hours at the temperature of 85 ℃ to obtain slurry.
Test for bacteriostasis and bacteriostasis stability
Test samples: the high-efficiency stable bacteriostatic powder obtained in examples 1 to 23 was used as test samples 1 to 23, and the high-efficiency stable bacteriostatic powder obtained in comparative examples 1 to 3 was used as control samples 1 to 3.
The test method comprises the following steps: weighing 10g of sample, adding the sample into a 90mL sterile water dilution bottle, shaking up, taking out after 30min in a water bath at 45 ℃, taking a sample to dilute 5mL of mixed solution, and putting the sample into a sterile plate for direct test. Test strains: escherichia coli (8099), 3 generations of Candida albicans (ATCC10231), three generations of Staphylococcus aureus (ATCC6538), and 3 generations of Staphylococcus aureus, provided by China center for culture Collection. The average bacteriostasis rate of the test samples 1-23 and the control samples 1-3 in different time (min) is detected according to GB15979-2002 appendix C4 of hygienic Standard for Disposable sanitary articles and 2002 edition of Disinfection.
And (3) test results: the test results of the test samples 1 to 23 and the control samples 1 to 3 are shown in Table 2. As can be seen from Table 2, the comparison of the test results of the test samples 1-5 and the control samples 1-3 shows that both propolis and bamboo vinegar can improve the overall bacteriostatic effect and stability of the high-efficiency stable bacteriostatic powder, and when the propolis and bamboo vinegar are mixed for use, the propolis and bamboo vinegar can play a good role in compounding and synergism, so that the bacteriostatic effect and stability of the product are greatly improved. The test results of the test samples 6-11 and the test sample 1 are compared to obtain the bacteriostatic composition, the pH regulator and the lubricant disclosed by the invention are all suitable for preparing the high-efficiency stable bacteriostatic powder, and the obtained high-efficiency stable bacteriostatic powder has good and stable bacteriostatic effect and stability. The test results of the test samples 12-20 and the test sample 1 are compared to obtain the spice extracting solution, the bacteriostatic effect and the stability of the high-efficiency stable bacteriostatic powder can be greatly improved by adding the spice extracting solution, and the spice extracting solution with good quality can be obtained by the extracting method of the spice extracting solution and the selection of natural spices disclosed by the invention. The test results of the test samples 21-23 and the test sample 1 are compared to obtain the test result, and the citral tool is added, so that the enzymatic activity in bacterial cell walls can be reduced in the application process, and the bacteriostatic effect and the stability of the high-efficiency stable bacteriostatic powder can be greatly improved.
TABLE 2 test results of test samples 1 to 23 and control samples 1 to 3
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.

Claims (9)

1. The efficient stable antibacterial powder is characterized by comprising the following components in parts by weight:
14-30 parts of a bacteriostatic composition;
0.8-1.6 parts of carbomer;
1-4 parts of carboxymethyl chitosan;
0.2-0.6 part of pH regulator;
0.1-0.5 part of lubricant;
7-13 parts of ethanol;
3-10 parts of pure water;
tween 800.3-1.5 parts;
0.5-0.9 part of propolis;
1.1-1.5 parts of bamboo vinegar;
0.2-0.8 part of chlorhexidine acetate.
2. The efficient and stable antibacterial powder according to claim 1, wherein the antibacterial composition is prepared by mixing the following components in parts by weight:
1-3 parts of sophora flavescens;
1.5-3 parts of giant knotweed;
3-6 parts of oldenlandia diffusa;
2-3 parts of phellodendron;
1.5-2.5 parts of fructus cnidii;
2-5 parts of sea clams;
1-4 parts of dragon's blood;
0.5-1.5 parts of borneol;
1.5-2 parts of fructus kochiae.
3. The high-efficiency stable bacteriostatic powder according to claim 1, wherein 0.1-0.3 part by weight of spice extract is further added into the components of the high-efficiency stable bacteriostatic powder.
4. The efficient and stable antibacterial powder according to claim 3, wherein the spice extracting solution is obtained by extracting 8-10 parts by weight of natural spices, and the natural spices are any one or more of mint, cinnamon, fennel and clove.
5. The efficient and stable antibacterial powder as claimed in claim 4, wherein the spice extract is obtained by extracting specifically the following steps:
s1, adding ethanol with the volume fraction of 70% -85% which is 3-5 times that of the natural spice in parts by weight, refluxing and extracting twice, wherein the first refluxing time is 30-50min, the second refluxing time is 20-30min, and then mixing the two refluxing extract solutions to obtain a mixed solution;
s2, putting the mixed solution in a water bath at the temperature of 60-80 ℃, volatilizing until no alcohol smell exists, adding water to adjust the volume until the mass concentration reaches 0.8-1.2g/L, and adjusting the pH value to 7-8 to obtain the spice extracting solution.
6. The high-efficiency stable bacteriostatic powder according to claim 1, wherein 0.5 to 1.3 parts by weight of citral is further added into the components of the high-efficiency stable bacteriostatic powder.
7. The highly effective stabilized antibacterial powder according to claim 1, wherein said pH adjusting agent is any one of sodium hydroxide, potassium hydroxide and triethanolamine.
8. The highly potent and stable antibacterial powder according to claim 1, wherein said lubricant is any one of glycerin, propylene glycol and polyethylene glycol.
9. A method for preparing the highly effective stable antibacterial powder according to claim 1, comprising the steps of:
step one, cleaning the bacteriostatic composition according to the corresponding weight part, drying, crushing, extracting by using a percolation method, and concentrating until the relative density is 0.8-1.5 at 50-60 ℃ to obtain a bacteriostatic extract;
step two, adding carbomer, carboxymethyl chitosan, ethanol, pure water, tween 80, propolis, bamboo vinegar and chlorhexidine acetate in required weight parts into the extract, stirring and mixing, and then distilling in a distillation kettle under reduced pressure for 2-3h at the temperature of 80-90 ℃ to obtain slurry;
and step three, adding the pH regulator and the lubricant in corresponding parts by weight into the slurry, fully stirring until the mixture is completely mixed, wherein the stirring speed is 500-800rpm, the stirring time is 20-30min, carrying out low-temperature solidification, and crushing to obtain the high-efficiency stable antibacterial powder.
CN201911062388.7A 2019-11-02 2019-11-02 Efficient stable antibacterial powder and preparation method thereof Pending CN110624062A (en)

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Application publication date: 20191231