CN104095999A - Ozonized borneol tea oil - Google Patents
Ozonized borneol tea oil Download PDFInfo
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- CN104095999A CN104095999A CN201410376761.7A CN201410376761A CN104095999A CN 104095999 A CN104095999 A CN 104095999A CN 201410376761 A CN201410376761 A CN 201410376761A CN 104095999 A CN104095999 A CN 104095999A
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- Prior art keywords
- oleum camelliae
- ozone
- tea oil
- borneolum syntheticum
- borneol
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses ozonized borneol tea oil. The ozonized borneol tea oil comprises ozone, borneol and tea oil; the tea oil per 1L includes 30 to 50g of borneol; the total input of ozone in tea oil per 1L is controlled to be 13.5 to 20.0g under temperature of 25 to 30 DEG C and pressure of 0.5 to 1.5bar. According to the ozonized borneol tea oil, the raw materials are cheap and easy to be obtained, the antibacterial effect can be obviously improved, the effects of diminishing inflammation, relieving pain and sterilizing are great, the wound healing is effectively promoted, the recovery of patients is sped up, a patient can easily accept, the ozone can be stably and slowly released, escherichia coli, staphylococcus aureus, candida albicans and the like can be eliminated within a short time, and good effect is particularly shown on treating chronic wounds like diabetic foot and acute wounds.
Description
Technical field
The present invention relates to a kind of ozonisation Oleum Camelliae antibacterial, antiinflammation that has.
Background technology
Ozone (chemical molecular formula O
3) be a kind of light blue gas that has careless fishy smell being formed by three oxygen atoms, the chemical property of ozone is very active, and its energy when free produces powerful Oxidation in moment, is usually used in sterilization, sterilization, removing toxic substances.Ozone is very easily dissolved in water, is dissolved in water and has stronger sterilizing ability, is 600-3000 times of chlorine, can rapidly antibacterial and virus be killed.And ozone decomposes rapidly, form oxygen, therefore there is not secondary pollution problem.
But ozone is extremely unstable in water, our detection data show, under room temperature, the half-life of ozone in water is about 5 minutes, and after 30 minutes, in water, concentration is extremely low.In in the past more than 20 year, people constantly increase the use research of ozone, find ozone quite stable in monounsaturated fatty acid, making ozone oil can preserve more than 2 years, what use was maximum at present is ozonisation olive oil, but the olive oil of China is mainly by import, olive oil quality on market is very different, price is the more than 10 times of edible oil, and it is antibacterial, antiinflammatory effect is not good enough, drug release is too fast, duration of efficacy is short, need to add a large amount of ozone amounts could obtain good effect, in addition, existing ozonisation Fructus Canarii albi wet goods is because its penetrating odor is difficult to be accepted by patient, and it is to escherichia coli, gold Portugal bacterium, the extinction effects of Candida albicans is not good, through actual use, find that the curative effect of its wound that degree of depth is festered is also undesirable.
Summary of the invention
The object of the present invention is to provide a kind of raw material cheap and easy to get, antibacterial effect can be improved significantly, there is good anti-inflammatory analgetic antisepsis, effectively promote the healing of wound, more be conducive to patient's rehabilitation, the stably slow release of more easily being accepted by patient goes out ozone, can eliminate at short notice escherichia coli, golden Portugal bacterium, Candida albicans etc., especially the degree of depth be festered and acute wounds has the ozonisation Borneolum Syntheticum Oleum Camelliae of good curative effect.
Technical scheme of the present invention is:
An ozonisation Borneolum Syntheticum Oleum Camelliae, is comprised of ozone, Borneolum Syntheticum and Oleum Camelliae, and wherein, in every 1L Oleum Camelliae, the content of Borneolum Syntheticum is 30～50g, and at temperature 25-30 ℃, pressure is under 0.5-1.5bar, and in every 1L Oleum Camelliae, controlling ozone, to pass into total amount be 13.5g～20.0g.
It is 15～18g that the present invention most preferably controls the total amount that ozone passes in every 1L Oleum Camelliae.
Preferred version of the present invention also comprises, ozone passes into and controls flow in process is 3g/h; The time that control ozone passes through is 5-6 hour.
In the preferred every 1L Oleum Camelliae of the present invention, the content of Borneolum Syntheticum is 30～40g; More preferably in every 1L Oleum Camelliae, the content of Borneolum Syntheticum is 30～35g.
Inventor finds by research repeatedly, in compositions of the present invention when ozone intake is during lower than scope of the presently claimed invention, can not reach preferably therapeutic effect, but be increased to when a certain amount of when the content of ozone, its bactericidal anti-inflammatory effect can not significantly improve yet.
Preparation process of the present invention is specifically preferably:
30-50g Borneolum Syntheticum is added in 1L Oleum Camelliae, put into blender, by medical oxygen, do oxygen source and make ozone by ozonator, output is 3g/h, being passed into temperature is 25-30 ℃, in the blender that pressure is 0.5-1.5bar, utilizes circulating pump to make oily ozonisation 5-6 hour to become water white transparency to oil.
Oleum Camelliae in the present invention is the distinctive traditional edible vegetable oil of China, is a kind of oils that monounsaturated fatty acid is main component of take.
Ozonisation Borneolum Syntheticum Oleum Camelliae of the present invention can be used as a kind of external-use oil preparation or adds in bandage and use, and also can be used as peroral dosage form, the uses such as suppository (for vagina, anorectal) and external dressing.
Usage: directly oral or make capsule, drop pill, bandage external application, fills in vagina, anorectal, outer painting and dressing are changed dressings etc.
Beneficial effect of the present invention
Because ozonisation olive oil of the prior art exists expensive raw material price, is difficult to obtain, and it is antibacterial, antiinflammatory effect is not good enough, and drug release is too fast, and duration of efficacy is short.And existing technical staff does not understand content requirement how to control the ozone in oil, just favourable antibacterial lifting, the lifting of rehabilitation efficacy.In addition, in ozone oil, whether also can add what composition, concrete how much interpolation, can more be conducive to effective healing and the rehabilitation of patient's wound again.And these all need inventor's further research.This by the Oleum Camelliae that uses in the present invention is conventional edible vegetable oil in China, and output is abundant, cheap and easy to get, can greatly reduce cost.Content by the ozone that passes into, makes it in Oleum Camelliae, can stablize and deposit, and can slowly discharge in follow-up use procedure.Moreover, the present inventor finds by further add the Borneolum Syntheticum of certain content in the Oleum Camelliae of ozonisation, finds its not only fragrance slightly, can make patient more acceptant, is ready to use; Prior effect and crux of the present invention are, by ozonisation Borneolum Syntheticum Oleum Camelliae of the present invention is provided, to have good synergistic function between each composition; Strengthened antibacterial, antiinflammatory and pain relieving antiseptic effect, particularly some degree of depth have been festered, the wound and the acute wounds that are difficult to effectively cure have fabulous therapeutic effect, and clinical verification example of the present invention has just well proved this point; And inventor is unexpected in experimentation finds that the present invention has the particularly preferred extinction effects to escherichia coli, golden Portugal bacterium, Candida albicans etc., at short notice with regard to divisible above-mentioned mushroom.In addition, the present invention passes into the content of ozone and Borneolum Syntheticum in ozonisation Borneolum Syntheticum Oleum Camelliae by control, can within the shortest time, obtain best therapeutic effect.By controlling the certain proportioning between ozone, Borneolum Syntheticum and Oleum Camelliae, ozonisation Borneolum Syntheticum Oleum Camelliae of the present invention not only can be used for treating the infectious skin diseases such as the dermatitis and eczemas such as steroid-dependent dermatitis, atopic dermatitis, rosacea, psoriasis, cutaneous fungal infection, impetigo, herpes zoster, herpes simplex, condyloma acuminatum etc., can also be for acute and chronic wound, burn and scald, decubital ulcer etc., all can obtain satisfied curative effect, in addition, the clinical effectiveness that applies ozonisation Borneolum Syntheticum Oleum Camelliae of the present invention shows, patient's acceptability is good.
Accompanying drawing explanation
Fig. 1 is the cross-reference figure for patient by ozonisation Borneolum Syntheticum Oleum Camelliae of the present invention.
The Oleum Camelliae that Fig. 2 is ozonisation Borneolum Syntheticum Oleum Camelliae that embodiment 1 is prepared and equivalent is for the cross-reference figure of mice wound.
Bromodeoxyribouridine (BrdU) the labelling coloration result of the Oleum Camelliae that Fig. 3 is ozonisation Borneolum Syntheticum Oleum Camelliae that embodiment 1 is prepared and equivalent after for mice wound.
The specific embodiment
Embodiment 1
30g Borneolum Syntheticum is added in 1L Oleum Camelliae, mix homogeneously, by medical oxygen, do oxygen source and make ozone by ozonator, output is 3g/h, at temperature 25-30 ℃, pressure is in the blender of 0.5-1.5bar, utilizes circulating pump to make Oleum Camelliae ozonisation 5 hours to oil become water white transparency, and what control ozone in Oleum Camelliae is 15g by total amount.
Embodiment 2
32g Borneolum Syntheticum is added in 1L Oleum Camelliae, mix homogeneously, according to the same method of embodiment 1, in control 1L Oleum Camelliae, ozone is 15g by total amount.
Embodiment 3
30g Borneolum Syntheticum is added in 1L Oleum Camelliae, and mix homogeneously, according to the same method of embodiment 1, makes Oleum Camelliae ozonisation 6 hours with circulating pump; The content that makes ozone in 1L Oleum Camelliae is 18g.
Embodiment 4
48g Borneolum Syntheticum is added in 1L Oleum Camelliae, mix homogeneously, according to the same method of embodiment 1, the content that makes ozone in 1L Oleum Camelliae is 18g.
Embodiment 5
35g Borneolum Syntheticum is added in 1L Oleum Camelliae, mix homogeneously, according to the same method of embodiment 1, the content that makes ozone in 1L Oleum Camelliae is 18g.
Comparative example 1
In control 1L olive oil, ozone is 15g by total amount, obtains ozonisation olive oil (ozone-depleting amount 15g/L).
Comparative example 2
Except not adding Borneolum Syntheticum, other obtains product ozone Oleum Camelliae (ozone-depleting amount 15g/L) according to the same method of embodiment 1.
Comparative example 3
Be only Oleum Camelliae, the Oleum Camelliae of its quality and embodiment 1 is identical in quality.
Comparative example 4
In 1L Oleum Camelliae, add 30 grams of Borneolum Syntheticums, the content that control passes into ozone is 12g, and other operation of method according to embodiment 1 obtains product Ozone Ice sheet Oleum Camelliae (ozone amount consumes 12g/L).
Comparative example 5
Be only normal saline, its volume is identical with embodiment 1 Oleum Camelliae volume.
The sterilization effect of product in table 1 test above-described embodiment and comparative example.
Note: 30min, 60min are the time of ozone oil effect pathogen
Embodiment 6
Clinical effectiveness test
For testing effect of the present invention, the patient that the ozonisation Borneolum Syntheticum Oleum Camelliae that embodiments of the invention 1 are prepared festers after for the left heel wound of 58 years old, before coating medicine, its pain has reached more than 50 days.
Wherein, occupation mode is external application, twice of every day.
Before external application, as shown in Fig. 1 (a), patient's wound is the ulcer of 6*3*1cm3 size and has purulent secretion, and stench, pain can not be walked.
After external application, first quarter moon left and right, as shown in Fig. 1 (b), wound clean, granulation well-grown, can walk, and pain obviously alleviates.
And after about one month, as shown in Fig. 1 (c), left heel ulcers incrustation healing, can normally walk.Further illustrate the present invention and can obtain good clinical effectiveness.
For testing effect of the present invention, by ozonisation Borneolum Syntheticum Oleum Camelliae of the present invention for many cases burn and scald and concurrent infection ulcer patient thereof, impetigo patient, eczematous dermatitis patient etc.
Wherein, occupation mode is external application, twice of every day.
Clinical experiment result shows, even the disease kind of festering for the above-mentioned degree of depth applies ozonisation Borneolum Syntheticum Oleum Camelliae of the present invention and can make its state of an illness alleviation at short notice, wound healing, has good effect.
Embodiment 7
The ozonisation Borneolum Syntheticum Oleum Camelliae preparing with embodiment 1 and Oleum Camelliae are treated respectively obesity (the diet-induced obesity of diet induced, DIO) model mice wound (simulation diabetic wounds), the 6mm size that this wound is mouse back suppresses wound A, the B of contracture.
Treatment group: external ozonisation every day Borneolum Syntheticum Oleum Camelliae 1 time, smear in wound B, treat 1 week.
Matched group: the Oleum Camelliae of external every day and treatment group equivalent 1 time, smear in wound A, treat 1 week.
As shown in Fig. 2 right side, wound B heals substantially, the healing that can promote DIO model mice wound with ozonisation Borneolum Syntheticum Oleum Camelliae treatment is described, and wound A is rotten to the corn, and treatment wound effective of ozonisation Borneolum Syntheticum Oleum Camelliae is described.In addition, as shown in Figure 3, bromodeoxyribouridine (BrdU) labelling coloration result shows that ozonisation Borneolum Syntheticum Oleum Camelliae can promote the propagation of keratinocyte and divide a word with a hyphen at the end of a line, the percentage rate for the treatment of group basal layer cell propagation is higher than matched group, have significant difference (p<0.05), the scope of its migration has significant difference (p<0.05) from edge of wound too to the length first proliferative cell.
Above-mentioned test shows, ozonisation Borneolum Syntheticum Oleum Camelliae of the present invention, for diabetes model wound, also has good therapeutic effect.
Claims (5)
1. an ozonisation Borneolum Syntheticum Oleum Camelliae, is characterized in that, ozone, Borneolum Syntheticum and Oleum Camelliae, consists of, wherein, in every 1L Oleum Camelliae, the content of Borneolum Syntheticum is 30～50g, at temperature 25-30 ℃, pressure is under 0.5-1.5bar, and in every 1L Oleum Camelliae, controlling ozone, to pass into total amount be 13.5g～20.0g.
2. ozonisation Borneolum Syntheticum Oleum Camelliae according to claim 1, is characterized in that, in every 1L Oleum Camelliae, controlling the total amount that ozone passes into is 15～18g.
3. ozonisation Borneolum Syntheticum Oleum Camelliae according to claim 2, is characterized in that, ozone passes into and controls flow in process is 3g/h; The time that control ozone passes through is 5-6 hour.
4. according to the ozonisation Borneolum Syntheticum Oleum Camelliae described in claim 1-3 any one, it is characterized in that, in every 1L Oleum Camelliae, the content of Borneolum Syntheticum is 30～40g.
5. ozonisation Borneolum Syntheticum Oleum Camelliae according to claim 4, is characterized in that, in every 1L Oleum Camelliae, the content of Borneolum Syntheticum is 30～35g.
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| CN201410376761.7A CN104095999B (en) | 2014-08-01 | 2014-08-01 | A kind of ozonisation Borneolum Syntheticum Oleum Camelliae |
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| CN201410376761.7A CN104095999B (en) | 2014-08-01 | 2014-08-01 | A kind of ozonisation Borneolum Syntheticum Oleum Camelliae |
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| CN104095999B CN104095999B (en) | 2016-02-24 |
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Cited By (11)
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| CN105597138A (en) * | 2016-02-25 | 2016-05-25 | 天津泰创生物科技有限公司 | Ozonide oil blasting bead and use method and dressing plaster |
| CN105769907A (en) * | 2016-03-08 | 2016-07-20 | 邓育德 | Effective antifungal complex and preparing method thereof |
| CN106615687A (en) * | 2016-11-21 | 2017-05-10 | 肖成运 | Novel compound feed additive |
| CN107088185A (en) * | 2017-06-09 | 2017-08-25 | 甘肃新天马制药股份有限公司 | A kind of ozone carburetion two-arch tunnel emulsion and preparation method and application |
| CN107349293A (en) * | 2017-08-05 | 2017-11-17 | 宁远县兴泰生物科技有限责任公司 | A kind of compound ozone oil and preparation method thereof |
| CN108057350A (en) * | 2017-12-14 | 2018-05-22 | 长沙思麦食品开发有限公司 | A kind of solubilization method of ozone in tea oil |
| CN108403713A (en) * | 2018-06-12 | 2018-08-17 | 南方医科大学南方医院 | A kind of ozone fluid composition, preparation method and gauze for promoting chronic wound care |
| CN109481457A (en) * | 2018-12-01 | 2019-03-19 | 济南秦鲁药业科技有限公司 | A kind of ozone oil sheet and preparation method |
| CN110368377A (en) * | 2019-08-14 | 2019-10-25 | 中南大学湘雅三医院 | A kind of nanometer of acidification aliphatic ester and its application |
| CN110585440A (en) * | 2019-10-29 | 2019-12-20 | 余浚龙 | Ozone base oil and ozone oil |
| CN110960616A (en) * | 2019-12-30 | 2020-04-07 | 湖北仟枝生物科技有限公司 | Antibacterial repairing ointment for treating bedsore gangrene and preparation method thereof |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105597138A (en) * | 2016-02-25 | 2016-05-25 | 天津泰创生物科技有限公司 | Ozonide oil blasting bead and use method and dressing plaster |
| CN105769907A (en) * | 2016-03-08 | 2016-07-20 | 邓育德 | Effective antifungal complex and preparing method thereof |
| CN106615687A (en) * | 2016-11-21 | 2017-05-10 | 肖成运 | Novel compound feed additive |
| CN107088185A (en) * | 2017-06-09 | 2017-08-25 | 甘肃新天马制药股份有限公司 | A kind of ozone carburetion two-arch tunnel emulsion and preparation method and application |
| CN107349293A (en) * | 2017-08-05 | 2017-11-17 | 宁远县兴泰生物科技有限责任公司 | A kind of compound ozone oil and preparation method thereof |
| CN108057350A (en) * | 2017-12-14 | 2018-05-22 | 长沙思麦食品开发有限公司 | A kind of solubilization method of ozone in tea oil |
| CN108403713A (en) * | 2018-06-12 | 2018-08-17 | 南方医科大学南方医院 | A kind of ozone fluid composition, preparation method and gauze for promoting chronic wound care |
| CN108403713B (en) * | 2018-06-12 | 2021-07-16 | 南方医科大学南方医院 | Ozone oil composition for promoting chronic wound healing, preparation method and gauze |
| CN109481457A (en) * | 2018-12-01 | 2019-03-19 | 济南秦鲁药业科技有限公司 | A kind of ozone oil sheet and preparation method |
| CN110368377A (en) * | 2019-08-14 | 2019-10-25 | 中南大学湘雅三医院 | A kind of nanometer of acidification aliphatic ester and its application |
| CN110585440A (en) * | 2019-10-29 | 2019-12-20 | 余浚龙 | Ozone base oil and ozone oil |
| CN110960616A (en) * | 2019-12-30 | 2020-04-07 | 湖北仟枝生物科技有限公司 | Antibacterial repairing ointment for treating bedsore gangrene and preparation method thereof |
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Effective date of registration: 20180918 Address after: 410205 9 yuan Hai Yuan Garden, 229 yuan yuan Road, Yuelu District hi tech Development Zone, Changsha, Hunan. Patentee after: HUNAN HAIZHI MEDICAL TECHNOLOGY CO., LTD. Address before: 410083 No. 138 Tongzi Po Road, Hexi Yuelu District, Changsha, Hunan Co-patentee before: HUNAN HAIZHI MEDICAL TECHNOLOGY CO., LTD. Patentee before: The Third Hospital of Central South University |