CN104958227A - Essence skin protection preparation with acne removing effect and preparation method thereof - Google Patents
Essence skin protection preparation with acne removing effect and preparation method thereof Download PDFInfo
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Abstract
The invention discloses essence skin protection preparation with an acne removing effect. The invention also discloses a preparation method of the essence skin protection preparation with the acne removing effect. Based on acne pathogenesis and clinical manifestation as research foundation and aiming at scientific acne treatment, the essence skin protection preparation with the acne removing effect is prepared by blending scientifically complex active matter serving as a main functional additive with refreshing and highly absorbable cosmetic ingredients. The essence skin protection preparation with the acne removing effect has antibacterial function and also has the effects of resisting to allergy, diminishing inflammation, controlling grease, removing cutin, fading acne marks and repairing acne-prone skin, effective treatment on acnes and acne marks is realized by virtue of multiple approaches, no toxic or side effect or skin stimulation is produced, an acne removing composition in a formula is specially designed for a complex acne pathogenic mechanism, is safe, effective and easy to absorb and can be easily added into an acne-removing cosmetic.
Description
Technical field
The present invention relates to a kind of essence skin care formulation with acne-removing and preparation method thereof, be applicable to medicine and personal care field.
Background technology
Acne is a kind of chronic inflammatory skin disease occurring in pilosebaceous unit position, is one of modal skin problem, acne another name comedo, acne.Acne is easily sent out in being in hebetic teenager, but due to reasons such as environmental pollution, the increases of urban life operating pressure, now increasing adult has the puzzlement of acne, and on their life, work, psychology, self-confident and social communication etc. create impact in various degree.
As everyone knows, the generation of acne is main and hypersteatosis, pilosebaceous duct block, bacteriological infection is bred and the factor such as inflammatory reaction is closely related.Acne clinical manifestation mainly be apt to occur in face, back the multi-form skin lesion such as acne, pimple, pustule, tuberosity for feature.Since entering 21 century, along with the increase of environmental pollution, study, operating pressure, increasing people has the puzzlement of acne in various degree, although there is increasing anti-acne series products to occur, but due to the cause of acne and trigger mechanism very complicated, this makes acne be difficult to treatment., but along with the progress of science and technology and the perfect of acne theoretical knowledge, following factor can produce important impact to acne:
Skin oil and fat is too much: the most possible long acne of adolescence, and the now growth of sebaceous gland, because the cause sebaceous gland of androgen becomes overacfivity, secretes a large amount of oils and fatss.Climacteric and the hormonal change of phenolics can cause endocrine regulation, also can trigger acne.
Clogging of pores: when skin oil and fat supersecretion, metabolism accelerate, the dyskeratosis of pilosebaceous duct causes that catheter blockage, keratodermatitis are blocked up, sweat flows out skin surface, be also easy to dirt and other impurity to be attached together blocking pore.
Bacteriological infection and inflammation: skin sebum is too much, after clogging of pores, for microorganism provides adapt circumstance, particularly propionibacterium acnes, decomposes satisfied fatty acid, produce a large amount of free fatties, these fatty acids infiltrate skin by pore, cause skin stress, the pigmentation etc. that generation acne, redness, inflammation are brought, simultaneously the antibacterial such as staphylococcus is bonded on skin by the pus of outflow, causes skin histology impaired.
Environmental stimuli: the factors such as diet is irregular, smoking excessive drinking, pressure are excessive, Exposure to Sunlight all may affect the hormone of people, metabolism thus trigger acne, abuse cosmetics and external preparation for skin medicine, may cause increasing the weight of of the acne clinical manifestations such as scytitis, cutaneous pigmentation and cicatrix (pox print) by factors such as hands extruding acne.
How in conjunction with cause and the trigger mechanism of acne complexity, design and develop more effectively and anti-acne can be reached for a long time, skin-protection product that desalination pox prints effect, be the technical barrier that current skin protection research field exists.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, providing a kind of essence skin care formulation with acne-removing, there is good elimination small pox, antiinflammatory releive and desalinate pox print effect.
Another object of the present invention is to provide a kind of above-mentioned preparation method with the essence skin care formulation of acne-removing.
A kind of technical scheme realizing above-mentioned purpose is: a kind of essence skin care formulation with acne-removing, A phase, B phase, C phase and D phase, and described A phase is made up of the raw material of following weight percentage ratio:
Described B phase is made up of the raw material of following weight percentage ratio:
Described C phase is made up of the raw material of following weight percentage ratio:
C phase plant sterol isostearate 0.1-1.0wt%
Polydimethylsiloxane 1.0-1.9wt%
Princepia utilis oil 0.02-0.08wt%;
Described D phase is made up of the raw material of following weight percentage ratio:
The percentage by weight sum of above-mentioned each raw material is 100%.
Above-mentioned a kind of essence skin care formulation with acne-removing, wherein, described acne-removing compositions is made up of the anti-acne raw material of following weight portion:
Above-mentioned a kind of essence skin care formulation with acne-removing, wherein, described acne-removing compositions is prepared by following method:
(1) silandiol salicylate and 1,2-pentanediol are added pre-dispersed pot successively, open and stir, mixing speed is 40 revs/min, and the temperature in pre-dispersed pot, to 40-45 DEG C, makes silandiol salicylate and 1,2-pentanediol mix homogeneously;
(2) added by Yunnan Rhizoma Paridis extract in described pre-dispersed pot, the temperature inside holding of 40-45 DEG C stirs 30 minutes, and Yunnan Rhizoma Paridis extract is dissolved completely;
(3) elm Ramulus et Folium Spiraeae Salicifolia extract, papain, beta glucan and nicotiamide are added successively in described pre-dispersed pot, stir after 30 minutes, filter discharging.
Of the present inventionly additionally provide a kind of preparation method with the essence skin care formulation of acne-removing, comprise the following steps:
(1) deionized water and EDETATE SODIUM are joined in emulsifying pot successively, subsequently card ripple acrylic acid (ester) class/C10-30 alcohol acrylate crosspolymers is sprinkled in the deionized water in described emulsifying pot, moistening 3-4 minute, open and stir and heater, mixing speed is 40 revs/min, when the temperature in emulsifying pot reaches 80-85 DEG C, allantoin is added in emulsifying pot, be stirred to allantoin and dissolve completely;
(2) will add in emulsifying pot after 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers butanediol wetting and dispersing in pre-configured container, then add in emulsifying pot after scrubbing pre-configured container with glycerol and glycerin polyether-26 successively, the temperature in emulsifying pot stirs at 80-85 DEG C of inside holding;
(3) prepare a stainless steel cask and prepare pot as oil phase, plant sterol isostearate, polydimethylsiloxane and Princepia utilis oil are put into successively oil phase preparation pot, stir and be heated to 70 ~ 75 DEG C, after the material in oil phase preparation pot dissolves completely, the material prepared by oil phase in pot drops in emulsifying pot;
(4) temperature in emulsifying pot is between 80-85 DEG C, and evacuation, opens homogenizing, and homogenizing speed is 3000 revs/min, and mixing speed is 40 revs/min, and homogenizing 8 minutes, opens cooling water temperature subsequently;
(5) by the hyaluronate sodium deionized water dissolving of 1.0%, make hyaluronate sodium premixed liquid, the deionized water of described 1.0% is loss water;
(6) when greenhouse cooling to 45 DEG C in emulsifying pot, by acne-removing compositions, described hyaluronate sodium premixed liquid, Herba portulacae extract and phenoxyethanol add in emulsifying pot successively, open homogenizing, homogenizing speed is 1500-2000 rev/min, homogenizing 5 minutes is to mix homogeneously, finally add aminomethyl propanol to neutralize, stir 30 minutes, mixing speed is 40 revs/min, after mix homogeneously, detect the pH value of the material in emulsifying pot, regulate the pH value of the material in emulsifying pot to 5.0.0-7.0 by aminomethyl propanol, material in emulsifying pot is crossed 200 eye mesh screen dischargings.
The essence skin care formulation with acne-removing of the present invention has bacteriostasis efficacy, also there is antiallergic antiinflammatory, control oily exfoliation, desalinate pox print and repair the effects such as small pox skin, the effective treatment to comedo, pox print is realized by number of ways, and have no side effect and skin irritation, acne-removing compositions in its formula, design for the complicated pathogeny of comedo specially, safe and effective and easily absorb, be easy to add application in acne-eliminating cosmetic.The preparation method with the essence skin care formulation of acne-removing of the present invention is easy, and safe and effective, has and well experiences sensation and result of use, have a lot of application prospects and market prospect.
Essence skin care formulation recommendation method of the present invention is: after clean of every day, essence skin care formulation is coated on small pox skin, and soft massage absorbs completely, and essence skin care formulation of the present invention clearly easily absorbs, and every day can repeatedly use.
Accompanying drawing explanation
Fig. 1 be use of the present invention there is the essence skin care formulation of acne-removing after long pox area skin oils and fats suppression ratio and melanin suppression ratio test result figure;
Fig. 2 uses of the present inventionly to have skin improvement effects figure after the essence skin care formulation of acne-removing.
Detailed description of the invention
The present inventor, in order to understand technical scheme of the present invention better, is described in detail by reference to the accompanying drawings below by embodiment particularly:
Table 1
The essence skin care formulation with acne-removing of embodiment 1-4 is prepared according to the proportioning raw materials of table 1.
In embodiment 1-4, the proportioning of the anti-acne raw material of acne-removing compositions is as shown in table 2:
Table 2
The acne-removing compositions in embodiment 1-4 is prepared according to the proportioning raw materials of table 2.
Acne-removing compositions provided by the invention is prepared by following method:
(1) silandiol salicylate and 1,2-pentanediol are added pre-dispersed pot successively, open and stir, mixing speed is 40 revs/min, and the temperature in pre-dispersed pot, to 40-45 DEG C, makes silandiol salicylate and 1,2-pentanediol mix homogeneously;
(2) added by Yunnan Rhizoma Paridis extract in described pre-dispersed pot, the temperature inside holding of 40-45 DEG C stirs 30 minutes, and Yunnan Rhizoma Paridis extract is dissolved completely;
(3) elm Ramulus et Folium Spiraeae Salicifolia extract, papain, beta glucan and nicotiamide are added successively in described pre-dispersed pot, stir after 30 minutes, filter discharging.
The source of above-mentioned raw materials is as shown in table 3:
Table 3
The Princepia utilis oil that Kunming Beitaini Biotechnology Co., Ltd. produces, its extraction process reference: the patent of invention of the applying date, to be the China Patent No. on November 22nd, 2011 be CN102406576A " a kind of both effectiveness skin care item containing Princepia utilis oil and preparation method ";
The Yunnan Rhizoma Paridis extract that Kunming Beitaini Biotechnology Co., Ltd. produces, its extraction process reference: the patent of invention " both effectiveness skin care item and preparation method containing the Acne treatment of Rhizoma Paridis extract " of the applying date, to be the China Patent No. on May 29th, 2012 be CN102670451A;
The Herba portulacae extract that Kunming Beitaini Biotechnology Co., Ltd. produces, its extraction process reference: the patent of invention of the applying date, to be the China Patent No. on July 29th, 2012 be CN102764217B " a kind of both effectiveness skin care item containing Herba portulacae extract and preparation method ".
The essence skin care formulation with acne-removing provided by the invention is prepared by following steps:
(1) deionized water and EDETATE SODIUM are joined in emulsifying pot successively, subsequently card ripple acrylic acid (ester) class/C10-30 alcohol acrylate crosspolymers is sprinkled in the deionized water in described emulsifying pot, moistening 3-4 minute, open and stir and heater, mixing speed is 40 revs/min, when the temperature in emulsifying pot reaches 80-85 DEG C, allantoin is added in emulsifying pot, be stirred to allantoin and dissolve completely;
(2) will add in emulsifying pot after 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers butanediol wetting and dispersing in pre-configured container, then add in emulsifying pot after scrubbing pre-configured container with glycerol and glycerin polyether-26 successively, the temperature in emulsifying pot stirs at 80-85 DEG C of inside holding;
(3) prepare a stainless steel cask and prepare pot as oil phase, plant sterol isostearate, polydimethylsiloxane and Princepia utilis oil are put into successively oil phase preparation pot, stir and be heated to 70 ~ 75 DEG C, after the material in oil phase preparation pot dissolves completely, the material prepared by oil phase in pot drops in emulsifying pot;
(4) temperature in emulsifying pot is between 80-85 DEG C, and evacuation, opens homogenizing, and homogenizing speed is 3000 revs/min, and mixing speed is 40 revs/min, and homogenizing 8 minutes, opens cooling water temperature subsequently;
(5) by the hyaluronate sodium deionized water dissolving of 1.0%, make hyaluronate sodium premixed liquid, the deionized water of described 1.0% is loss water;
(6) when greenhouse cooling to 45 DEG C in emulsifying pot, by acne-removing compositions, described hyaluronate sodium premixed liquid, Herba portulacae extract and phenoxyethanol add in emulsifying pot successively, open homogenizing, homogenizing speed is 1500-2000 rev/min, homogenizing 5 minutes is to mix homogeneously, finally add aminomethyl propanol to neutralize, stir 30 minutes, mixing speed is 40 revs/min, after mix homogeneously, detect the pH value of the material in emulsifying pot, regulate the pH value of the material in emulsifying pot to 5.0.0-7.0 by aminomethyl propanol, material in emulsifying pot is crossed 200 eye mesh screen dischargings.
The selected acne-removing compositions had in the essence skin care formulation of acne-removing of the present invention, wherein Yunnan Rhizoma Paridis extract has outstanding suppression propionibacterium acnes effect; Salicyclic acid derivatives and silandiol salicylate have outstanding antiphlogistic effects; Elm Ramulus et Folium Spiraeae Salicifolia extract is mainly used in controlling oily active matter, can effectively control and regulate fat secretion; Papain effectively can remove the cutin of the dyskeratosis of small pox skin and the cutin of blocking pore, also can accelerate small pox cut and absorb functional component; Nicotiamide antibacterially can have again the effect desalinating pigment, even skin tone significantly; Beta glucan can form layer protecting film on small pox skin, can repair small pox wound skin, small pox skin of releiving again; Pentanediol both can dissolve above-mentioned effect active matter to greatest extent, the infiltration of effect active matter can also be promoted, pentanediol perfection has played the usefulness of above-mentioned 6 effect active matters, additionally provide a salubrious use sensation easily absorbed, therefore the acne-removing compositions effect in the present invention complements each other, realize effectively treating comedo, pox print, and having no side effect and skin irritation by number of ways.And the anti-acne raw material of acne-removing compositions in the present invention is conveniently easy to get,
Study on the stability is tested:
Study on the stability test is carried out to the essence skin care formulation with acne-removing of the above-mentioned embodiment 1-4 prepared, successively at-15 DEG C, under 49 DEG C of conditions, test 30 days respectively, 60 days and 90 days, test the stability of essence skin care formulation of the present invention, study on the stability test result is as shown in table 4:
Table 4
The study on the stability test result display of table 4, the essence skin care formulation with acne-removing of embodiment 1-4 is 49 DEG C of heat-resisting investigations, after returning to room temperature, mastic is without oil-water separation phenomenon ,-15 DEG C of cold-resistant investigations, front without obvious Traits change with test after returning to room temperature.Anti-acne essence preparation of the present invention, when higher than having excellent stability when GB, can meet the demand of listing.
Antibacterial experiment in vitro
The experimental principle of antibacterial experiment in vitro is:
Inoculating in the culture medium for examination strain, imposing quantitative embodiment 1 and preparing sample, utilizing the scattering and permeating effect of sample in agar culture medium, arrive certain scope through sample permeates diffusion after a period of time.In the scope that Mlc reaches, the production of indicator bacteria will be suppressed, produces an aseptic transparent region, become inhibition zone.In certain condition and certain limit, the diameter of inhibition zone and the logarithm of sample concentration linearly functional relationship.Utilize this principle, can the size of bacteriostasis and sterilization ability of compare test product.The inhibition zone size of parallel 1, parallel 2, parallel 3 representative samples, one group of experimental data will do three parallel laboratory tests, last experimental result be get three parallel numerical value meansigma methods as last result.
Antibacterial experiment in vitro inhibition zone the results are shown in Table 5:
Group | Parallel 1 | Parallel 2 | Parallel 3 | Average result (mm) |
Propionibacterium acnes | 19.35 | 19.35 | 20.35 | 19.68 |
Staphylococcus aureus | 18.23 | 18.25 | 18.36 | 18.28 |
Staphylococcus epidermidis | 40.14 | 39.14 | 42.14 | 40.47 |
Table 5
The criterion of In Vitro Bacteriostasis qualitative results: it is insensitive (-) that antibacterial circle diameter size is less than 8mm, 8-13mm is less sensitive (+), 13-19mm is medium sensitivity (++), and more than 19mm is extremely sensitive (+++).Can be drawn by the above results, the essence preparation of the embodiment of the present invention 1 has good fungistatic effect to propionibacterium acnes and staphylococcus epidermidis, inventor utilizes other embodiment to prepare sample and repeats above-mentioned experiment, result is similar with embodiment 1, all has good fungistatic effect to propionibacterium acnes and staphylococcus epidermidis.
Product control oil, desalination pox print effect experimental
The experimental technique of product control oil, desalination pox print effect experimental is:
Embodiment 1-4 and commercially available product for resolving poxes are tried out for a long time.Test number is 60 people, skin characteristic is oily skin, slight and moderate comedo skin, test period is 28 days, tester is divided into 6 groups, often organize 10 people, use embodiment 1-4, commercially available product for resolving poxes and do not use any product for resolving poxes (blank group) respectively, use test products after clean of tester every day, every day uses twice.Tester is in the melanin content in the 0th day, the 7th day, the 14th day, the 28th day content with German CK company MC900 skin evaluation center Instrument measuring long pox area skin oils and fats, pox print region, and the oils and fats suppression ratio of long pox area skin and melanin suppression ratio test result are as shown in Figure 1.Tester needs the use sense such as self assessment anti-acne antiinflammatory situation, pore contractive effect, the glossy minimizing of skin to be subject to simultaneously.Test result is as shown in table 6 and Fig. 2:
Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Commercial samples | Blank | |
Small pox eradicating efficacy | 8 | 8.2 | 8.3 | 8.1 | 7.5 | 2.5 |
The glossy minimizing of skin | 8.1 | 8.1 | 8.2 | 8.5 | 7.1 | 2.3 |
Pox print fading effect | 8.2 | 8.4 | 8.3 | 8.2 | 2.5 | 2.0 |
Pore shrinks situation | 8.1 | 8.1 | 8.3 | 8.2 | 7.5 | 1.0 |
Antiinflammatory is releived effect | 8.5 | 8.6 | 8.3 | 8.2 | 3.6 | 3.5 |
Salubrious absorption sensation | 8.5 | 8.3 | 8.1 | 8 | 4.8 | 2.8 |
Table 6
The test result of table 6, Fig. 1 and Fig. 2 shows: the essence skin care formulation anti-acne that the present invention combines containing acne-removing, antiinflammatory, desalination pox print and sebum reduce effect and be better than commercially available product for resolving poxes, simultaneously long-term trial effect is also obviously better than commercially available product for resolving poxes, especially eliminate in small pox, antiinflammatory releived, desalinate pox print, the glossy minimizing of skin, in salubrious easily absorption etc.
Those of ordinary skill in the art will be appreciated that, above embodiment is only used to the present invention is described, and be not used as limitation of the invention, as long as in spirit of the present invention, all will drop in Claims scope of the present invention the change of the above embodiment, modification.
Claims (4)
1. have an essence skin care formulation for acne-removing, it is characterized in that, comprise A phase, B phase, C phase and D phase, described A phase is made up of the raw material of following weight percentage ratio:
Described B phase is made up of the raw material of following weight percentage ratio:
Described C phase is made up of the raw material of following weight percentage ratio:
C phase plant sterol isostearate 0.1-1.0wt%
Polydimethylsiloxane 1.0-1.9wt%
Princepia utilis oil 0.02-0.08wt%;
Described D phase is made up of the raw material of following weight percentage ratio:
The percentage by weight sum of above-mentioned each raw material is 100%.
2. a kind of essence skin care formulation with acne-removing according to claim 1, it is characterized in that, described acne-removing compositions is made up of the anti-acne raw material of following weight portion:
3. a kind of essence skin care formulation with acne-removing according to claim 2, it is characterized in that, described acne-removing compositions is prepared by following method:
(1) silandiol salicylate and 1,2-pentanediol are added pre-dispersed pot successively, open and stir, mixing speed is 40 revs/min, and the temperature in pre-dispersed pot, to 40-45 DEG C, makes silandiol salicylate and 1,2-pentanediol mix homogeneously;
(2) added by Yunnan Rhizoma Paridis extract in described pre-dispersed pot, the temperature inside holding of 40-45 DEG C stirs 30 minutes, and Yunnan Rhizoma Paridis extract is dissolved completely;
(3) elm Ramulus et Folium Spiraeae Salicifolia extract, papain, beta glucan and nicotiamide are added successively in described pre-dispersed pot, stir after 30 minutes, filter discharging.
4. there is a preparation method for the essence skin care formulation of acne-removing as claimed in claim 1, it is characterized in that, comprise the following steps:
(1) deionized water and EDETATE SODIUM are joined in emulsifying pot successively, subsequently card ripple acrylic acid (ester) class/C10-30 alcohol acrylate crosspolymers is sprinkled in the deionized water in described emulsifying pot, moistening 3-4 minute, open and stir and heater, mixing speed is 40 revs/min, when the temperature in emulsifying pot reaches 80-85 DEG C, allantoin is added in emulsifying pot, be stirred to allantoin and dissolve completely;
(2) will add in emulsifying pot after 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers butanediol wetting and dispersing in pre-configured container, then add in emulsifying pot after scrubbing pre-configured container with glycerol and glycerin polyether-26 successively, the temperature in emulsifying pot stirs at 80-85 DEG C of inside holding;
(3) prepare a stainless steel cask and prepare pot as oil phase, plant sterol isostearate, polydimethylsiloxane and Princepia utilis oil are put into successively oil phase preparation pot, stir and be heated to 70 ~ 75 DEG C, after the material in oil phase preparation pot dissolves completely, the material prepared by oil phase in pot drops in emulsifying pot;
(4) temperature in emulsifying pot is between 80-85 DEG C, and evacuation, opens homogenizing, and homogenizing speed is 3000 revs/min, and mixing speed is 40 revs/min, and homogenizing 8 minutes, opens cooling water temperature subsequently;
(5) by the hyaluronate sodium deionized water dissolving of 1.0%, make hyaluronate sodium premixed liquid, the deionized water of described 1.0% is loss water;
(6) when greenhouse cooling to 45 DEG C in emulsifying pot, by acne-removing compositions, described hyaluronate sodium premixed liquid, Herba portulacae extract and phenoxyethanol add in emulsifying pot successively, open homogenizing, homogenizing speed is 1500-2000 rev/min, homogenizing 5 minutes is to mix homogeneously, finally add aminomethyl propanol to neutralize, stir 30 minutes, mixing speed is 40 revs/min, after mix homogeneously, detect the pH value of the material in emulsifying pot, regulate the pH value of the material in emulsifying pot to 5.0.0-7.0 by aminomethyl propanol, material in emulsifying pot is crossed 200 eye mesh screen dischargings.
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CN105687109A (en) * | 2016-03-09 | 2016-06-22 | 广州千百度化妆品有限公司 | Acne-removing repair essence |
CN107440992A (en) * | 2017-08-22 | 2017-12-08 | 安徽省中日农业环保科技有限公司 | A kind of preparation method of the anti-acne essence containing Rhizoma Paridis extract |
CN107951823A (en) * | 2017-12-06 | 2018-04-24 | 懿奈(上海)生物科技有限公司 | It is a kind of that there is the composition of oil-control and its application |
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CN110169943A (en) * | 2019-07-09 | 2019-08-27 | 许富明 | Net white formula of a kind of anti-acne and preparation method thereof |
CN112294715A (en) * | 2019-07-31 | 2021-02-02 | 上海金皮宝制药有限公司 | Composition with acne removing and repairing effects, skin care preparation and preparation method of skin care preparation |
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CN105395438A (en) * | 2015-12-31 | 2016-03-16 | 青岛美博生物技术有限公司 | Acne-removal skin-care lotion and preparation method thereof |
CN105687109A (en) * | 2016-03-09 | 2016-06-22 | 广州千百度化妆品有限公司 | Acne-removing repair essence |
CN107440992A (en) * | 2017-08-22 | 2017-12-08 | 安徽省中日农业环保科技有限公司 | A kind of preparation method of the anti-acne essence containing Rhizoma Paridis extract |
CN107951823A (en) * | 2017-12-06 | 2018-04-24 | 懿奈(上海)生物科技有限公司 | It is a kind of that there is the composition of oil-control and its application |
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CN110051626B (en) * | 2018-01-18 | 2022-10-04 | 杜权 | Two-phase oil preparation and application thereof |
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