CN115844792A - Acne-removing microemulsion from natural sources and preparation method thereof - Google Patents
Acne-removing microemulsion from natural sources and preparation method thereof Download PDFInfo
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- CN115844792A CN115844792A CN202211490068.3A CN202211490068A CN115844792A CN 115844792 A CN115844792 A CN 115844792A CN 202211490068 A CN202211490068 A CN 202211490068A CN 115844792 A CN115844792 A CN 115844792A
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- acne
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- microemulsion
- essential oil
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Abstract
The invention discloses an acne-removing microemulsion with a natural source and a preparation method thereof. The microemulsion comprises the following raw materials in percentage by weight: 0.01-0.1% of alkannin, 0.01-0.2% of tanshinone II, 0.01-0.2% of licochalcone A, 0.01-0.5% of baicalin, 0.01-0.5% of paeonol, 0.01-0.5% of matrine, 0.01-0.5% of salicin, 0.01-0.5% of clove oil, 0.01-0.5% of thyme essential oil, 0.01-1% of rosemary essential oil, 0.01-1% of lavender essential oil, 0.01-1% of blackberry lily extract, 0.01-1% of dandelion extract, 0.1-2% of tocopherol acetate, 1-5% of sucrose ester, 1-15% of glycerol, 1-10% of butanediol, 0.01-0.2% of oat beta-glucan, 1-3% of betaine, 0.1-0.8% of p-hydroxyphenyl, 0.1, 2-hexanediol, and the balance of deionized water. The invention adopts sucrose ester as an emulsifier of microemulsion, compound essential oil and traditional Chinese medicine extract. The acne-removing microemulsion is beneficial to percutaneous absorption, and the essential oil is beneficial to the penetration of the traditional Chinese medicine extract, so that the acne-removing effect is obviously improved. The acne-removing microemulsion of the invention can balance grease secretion, inhibit bacteria and diminish inflammation, and does not leave acne marks.
Description
Technical Field
The invention relates to a facial skin care product, belongs to the technical field of cosmetics, and particularly relates to acne-removing microemulsion from natural sources and a preparation method thereof.
Background
Acne, known as acne, is a chronic inflammatory disease of the sebaceous glands of the hair follicle and has certain damage capacity. Under the vigorous stimulation of male hormone, acne is caused by factors such as excessive sebum secretion, blockage of pilosebaceous ducts, bacterial infection, inflammatory reaction and the like. The acne is divided into comedo, papule, pustule, nodule and cyst, most acnes, especially the papule, pustule, nodule and cyst can generate scars, the appearance of a patient is seriously influenced, the psychology of the patient is further adversely influenced, and serious troubles are caused to many pox patients. Acne marks are formed by infection and inflammation or external force extrusion, and are usually formed by the fact that the acne is not treated properly in time when the acne occurs, and the skin tissue is damaged due to the inflammatory reaction of skin cells, so that the acne marks are generated.
The epidermis of the skin has a dense stratum corneum which blocks the invasion of foreign substances and has a natural barrier function. Most of the existing acne removing products have poor acne removing effect, and the main reason is that the effective components for removing acnes are poor in transdermal absorption and cannot achieve the effects of sterilization, inflammation diminishing and repair.
Chinese patent application No. CN201610199885.1 discloses an acne-removing cosmetic composition, which contains emodin, azelaic acid and retinol palmitate, can thoroughly remove and cut off in vivo heat, blood stasis and dampness hosts, practically achieves the effects of removing acne and repairing skin, and has the characteristics of quick response, no toxic or side effect, strong affinity with skin, safety, comfort and no irritation. However, the acne-removing skin-care microemulsion has the problems and defects that the traditional PEG emulsifier is adopted in the acne-removing skin-care microemulsion, the use amount is large, the irritation to skin is large, and the acne-removing skin-care microemulsion is not suitable for long-term use. Chinese patent application No. CN201910490632.3 discloses an anti-inflammatory acne-removing skin-care emulsion, which relates to the field of cosmetics, and comprises the following components in parts by weight: 5.7-12.5 parts of humectant, 0.1-0.5 part of thickening agent, 6-10 parts of softening agent, 0.2-0.7 part of bacteriostatic agent, 4.1-9.4 parts of acne removing agent, 0.1-0.5 part of chelating agent, 1.5-3 parts of emulsifier, 0.1-0.3 part of pH regulator, 0.011-0.15 part of essential oil and the balance of water. The skin care lotion has the dual repairing effects of oil control and acne removal. But the acne-removing skin-care lotion has the problems and defects that the published acne-removing skin-care lotion is common lotion, the particle size of the lotion is large, the transdermal absorption of active ingredients is poor, and the acne-removing effect is poor.
Although a large amount of acne removing components are added in the traditional acne removing product, the traditional acne removing product has poor acne removing effect due to the fact that the traditional acne removing product is poor in absorption effect and wastes the acne removing components.
Disclosure of Invention
In order to solve the percutaneous absorption effect of an acne-removing product, the invention aims to provide an acne-removing microemulsion with a natural source, and the produced acne-removing microemulsion greatly improves the percutaneous absorption and achieves the effect of half the work of a medicine by adopting sucrose ester which is safe and mild and has a natural source as an emulsifier of the microemulsion and a special production process to compound essential oil and a traditional Chinese medicine extract.
The invention also aims to provide a preparation method of the acne-removing microemulsion from natural sources.
In order to achieve the purpose, the invention adopts a special production process, glycerin is put in an oil phase, and partial deionized water is added while stirring, while the traditional production process mostly puts the glycerin in a water phase, and the technical scheme is as follows:
the acne-removing microemulsion with natural sources comprises the following raw materials in percentage by weight:
0.01-0.1% of alkannin, 0.01-0.2% of tanshinone II, 0.01-0.2% of licochalcone A, 0.01-0.5% of baicalin, 0.01-0.5% of paeonol, 0.01-0.3% of matrine, 0.01-0.5% of salicin, 0.01-0.5% of clove oil, 0.01-0.5% of thyme essential oil, 0.01-1% of rosemary essential oil, 0.01-1% of lavender essential oil, 0.01-1% of blackberry lily extract, 0.01-1% of dandelion extract, 0.1-2% of tocopherol acetate, 1-5% of sucrose ester, 1-15% of glycerol, 1-10% of butanediol, 0.01-0.2% of oat beta-glucan, 1-3% of betaine, 0.1-0.8% of p-hydroxy-phenyl ethyl ketone, 0.1-0.8% of 1, 2-hexanediol and the balance of deionized water.
Further, the acne-removing microemulsion with natural sources comprises the following raw materials in percentage by weight:
0.01-0.04% of alkannin, 0.04-0.06% of tanshinone II, 0.01-0.05% of licochalcone A, 0.01-0.3% of baicalin, 0.1-0.3% of paeonol, 0.01-0.25% of matrine, 0.1-0.3% of salicin, 0.01-0.2% of clove oil, 0.01-0.3% of thyme essential oil, 0.01-0.8% of rosemary essential oil, 0.01-0.9% of lavender essential oil, 0.1-0.25% of blackberry lily extract, 0.1-0.3% of dandelion extract, 1.2-1.6% of tocopherol acetate, 4-4.5% of sucrose ester, 8-10% of glycerol, 4-6% of butanediol, 0.03-0.1% of oat beta-glucan, 1-2.5% of betaine, 0.2-0.7% of p-hydroxyacetophenone, 1, 0.2-0.7% of 2-hexanediol and the balance of deionized water.
The emulsifier adopted by the acne-removing microemulsion from natural sources is sucrose ester from natural sources, and the sucrose ester is one or more of sucrose poly-cottonseed oleate, sucrose stearate and sucrose laurate from natural sources.
1-15% of glycerin, 1-10% of butanediol, 0.01-0.2% of oat beta-glucan and 1-3% of betaine, and has moistening and moisturizing effects.
0.1-0.8% of p-hydroxyacetophenone and 0.1-0.8% of 1, 2-hexanediol are used for antisepsis.
In addition, the invention also discloses acne-removing microemulsion from natural sources, which is prepared from the following phase A component, phase B component, phase C component, phase D component and phase E component in percentage by weight:
the phase A component comprises: 1-5% of sucrose ester and 0.1-2% of tocopherol acetate;
the phase B component comprises: 0.01 to 0.1 percent of alkannin, 0.01 to 0.2 percent of tanshinone II, 0.01 to 0.2 percent of licochalcone A, 0.01 to 0.5 percent of paeonol, 0.01 to 0.5 percent of clove oil, 0.01 to 0.5 percent of thyme essential oil, 0.01 to 1 percent of rosemary essential oil and 0.01 to 1.0 percent of lavender essential oil;
the phase C component comprises: 1-15% of glycerol;
the phase D component comprises: 10-20% of deionized water;
the phase E component comprises: 1-10% of butanediol, 0.01-0.2% of oat beta-glucan, 1-3% of betaine, 0.01-0.5% of baicalin, 0.01-0.5% of matrine, 0.01-0.5% of salicin, 0.01-0.1% of blackberry lily extract, 0.01-1% of dandelion extract, 0.1-0.8% of p-hydroxyacetophenone, 0.1-0.8% of 1, 2-hexanediol and the balance of deionized water.
The preparation method of the acne-removing microemulsion with natural sources comprises the following steps of weighing raw materials in percentage by weight:
1) Adding all the components of the phase A into a reaction kettle, stirring and heating to 70-75 ℃, preserving heat for 20 minutes, stirring until the components are completely dissolved, adding all the components of the phase B, preserving heat for 30 minutes at 55-60 ℃, stirring until the components are completely dissolved, adding the components of the phase C, stirring and heating to 55-60 ℃;
2) Slowly adding the phase D which is preheated to 50 ℃ while stirring the mixture (A phase, B phase and C phase) prepared in the step 1) until all the phase D is added;
3) Adding all the components of the phase E into a water kettle, stirring and heating to 80-85 ℃, preserving heat for 20 minutes, stirring until the components are completely dissolved, and then cooling to 50 ℃ for later use;
4) Mixing the liquids prepared in the steps 2) and 3), and stirring for 10 minutes to obtain the acne-removing microemulsion from natural sources.
By means of the technical scheme, the invention has the following advantages and beneficial technical effects:
1) The acne-removing microemulsion with natural sources prepared by the invention is semitransparent to transparent liquid, has high stability, good transdermal absorption effect, quick acne-removing effect and no scar;
2) The invention adopts sucrose ester which is naturally sourced, safe and mild as an emulsifier of the microemulsion and adopts a special production process, compound essential oil and traditional Chinese medicine extract;
3) The inventive acne-removing microemulsion favors transdermal absorption (table 5 using test results of example 1 and comparative example 1: the microemulsion has better acne removing effect, which indicates that the acne removing components have better percutaneous absorption), and the essential oil contributes to the osmosis of the traditional Chinese medicine extract, so that the acne removing effect is obviously improved (table 6 uses the test results of the example 4 and the comparative example 4);
4) The acne removing microemulsion of the present invention can be rapidly absorbed transdermally (table 5 using the test results of example 1 and comparative example 1: the microemulsion has better acne removing effect, indicates that the acne removing components have better percutaneous absorption), balances oil secretion, inhibits bacteria and diminishes inflammation, and does not leave acne marks.
Drawings
Fig. 1 is a color display diagram of the acne-removing microemulsion prepared from natural sources.
Detailed Description
The invention discloses an acne-removing microemulsion with a natural source and a preparation method thereof. The microemulsion for removing acnes from natural sources comprises the following raw material components in percentage by weight:
0.01-0.1% of alkannin, 0.01-0.2% of tanshinone II, 0.01-0.2% of licochalcone A, 0.01-0.5% of baicalin, 0.01-0.5% of paeonol, 0.01-0.5% of matrine, 0.01-0.5% of salicin, 0.01-0.5% of clove oil, 0.01-0.5% of thyme essential oil, 0.01-1% of rosemary essential oil, 0.01-1% of lavender essential oil, 0.01-1% of blackberry lily extract, 0.01-1% of dandelion extract, 0.1-2% of tocopherol acetate, 1-5% of sucrose ester, 1-15% of glycerol, 1-10% of butanediol, 0.01-0.2% of oat beta-glucan, 1-3% of betaine, 0.1-0.8% of p-hydroxy-phenyl ethyl ketone, 0.1-0.8% of 1, 2-hexanediol and the balance of deionized water.
Although a large amount of acne removing components are added in the traditional acne removing product, the traditional acne removing product has poor acne removing effect due to the fact that the traditional acne removing product is poor in absorption effect and wastes the acne removing components.
All the raw material components of the invention are commercial products.
Alkannin: produced by million li resistant sparrow biotechnology limited.
Tanshinone II, baicalin, paeonol, matrine and salicin: produced by co-creation biotechnology limited of north and river.
Licochalcone: produced by Gansu pan-planted pharmaceuticals, inc.
Oat beta-glucan: produced by shanghai cheng bio-technology limited.
Clove oil, thyme essential oil, rosemary essential oil, lavender essential oil: produced by henceforth natural perfume oils limited.
Blackberry lily extract, dandelion extract: produced by Zhongzhi (Shandong) Biotech limited.
Tocopherol acetate: produced by basf (china) limited.
Sucrose ester: produced from the hongnuo chemical technology limited of Shantou city.
Glycerol: produced by high-tech company, limited, de source (china).
Butanediol: produced from the capital xylonite (china) investment company, ltd.
P-hydroxyacetophenone, 1, 2-hexanediol: produced by demi-shi (shanghai) ltd.
The invention adopts sucrose ester which is naturally sourced, safe and mild as an emulsifier of the microemulsion and adopts a special production process, compound essential oil and traditional Chinese medicine extract.
The acne-removing microemulsion is beneficial to absorption, and the essential oil is beneficial to the osmosis of the traditional Chinese medicine extract, so that the acne-removing effect is obviously improved.
The acne-removing microemulsion can be quickly absorbed, balance grease secretion, inhibit bacteria and diminish inflammation, and does not leave acne marks.
As shown in figure 1, the acne-removing microemulsion prepared by the invention is semitransparent to transparent liquid, has high stability, good transdermal absorption effect, quick acne-removing effect and no scar.
The active ingredients used in the present invention have the following effects:
alkannin: the skin-care product has the effects of resisting inflammation and bacteria, promoting the proliferation of granulation tissues, obviously accelerating wound healing, relieving skin keratinization and improving the state of horny layer by using a small amount of the skin-care product; removing blood stasis, acne marks and pimples, inhibiting capillary permeability, promoting wound healing, and removing mottle.
Tanshinone II: has antibacterial, antiinflammatory, blood circulation promoting, blood stasis removing, and wound healing promoting effects; antiandrogen effect, sebum production reduction, and 5 a-reductase inhibition, and is highly sensitive to acne bacillus and Staphylococcus aureus.
Licochalcone a: has remarkable anti-inflammatory property (the effect is better than that of dexamethasone and hydrocortisone), remarkably inhibits Propionibacterium acnes and inhibits proliferation and metabolism of fat cells, and can be used for treating acne and comedo.
Baicalin: has antioxidant and antiinflammatory effects, and can remarkably inhibit Propionibacterium acnes and Staphylococcus aureus, inhibit androgen level, improve hyperkeratosis of pilosebaceous canal, reduce sebum secretion, and inhibit 5 a-reductase.
Paeonol: it has effects in inhibiting free radical generation in cell, whitening skin, reducing and discoloring pigment deposited in skin, removing blood stasis and speckle, relieving inflammation, relieving swelling and pain, resisting allergy and virus.
Matrine: has effects in clearing away heat and toxic materials, relieving inflammation, resisting pathogenic microorganism (antibacterial, antifungal, and antiviral), regulating immunity, and inhibiting pathogenic bacteria and dermatophytes.
Salicin: can soften cutin, make it fall off, reduce pore obstruction, and has good effect on adolescent acne and common acne. Salicin has aspirin-like properties, is an effective anti-inflammatory ingredient, and is traditionally used to heal wounds.
Clove oil: contains eugenol extract, and has effects in inhibiting activity of Propionibacterium acnes and reducing related inflammatory reaction.
Thyme essential oil: one of the strongest antimicrobial agents aids in wound healing, and treatment of eczema and pimple skin conditions accelerates healing for acne, eczema, or other skin disorders.
Rosemary essential oil: oxidation resistance, inflammation diminishing and strong sterilization; rosemary is a strong astringent and has a potent effect.
Lavender essential oil: clearing away heat and toxic materials, cleaning skin, controlling oil content, rapidly penetrating hair follicle, sterilizing, resisting bacteria, promoting cell regeneration, promoting rapid healing of acne and small wound, recovering skin connective tissue, and preventing scar and acne mark.
Shooting: can dissolve cutin, accelerate superficial inflammation to subside, promote hair follicle epithelial cell hyperplasia, loosen and expel acne, accelerate closed acne to become open acne, and promote subsidence of pimple and nodule, so as to heal acne quickly.
Dandelion: has antibacterial and antiinflammatory effects, and has good softening effect on horny layer. Obviously inhibits staphylococcus aureus and also has obvious inhibiting effect on the activity of 5 a-reductase.
Tocopherol acetate: has effects in resisting oxidation, scavenging free radicals, inhibiting tyrosinase activity, preventing pigmentation, and improving skin color.
The invention discloses an acne-removing microemulsion with a natural source and a preparation method thereof.
The acne-removing microemulsion with natural sources is prepared from the following phase A components, phase B components, phase C components, phase D components and phase E components in percentage by weight:
the phase A component comprises: 1 to 5 percent of sucrose ester and 0.1 to 2 percent of tocopherol acetate;
the phase B component comprises: 0.01 to 0.1 percent of alkannin, 0.01 to 0.2 percent of tanshinone II, 0.01 to 0.2 percent of licochalcone A, 0.01 to 0.5 percent of paeonol, 0.01 to 0.5 percent of clove oil, 0.01 to 0.5 percent of thyme essential oil, 0.01 to 1 percent of rosemary essential oil and 0.01 to 1.0 percent of lavender essential oil;
the phase C component comprises: 1-15% of glycerol;
the phase D component comprises: 10-20% of deionized water;
the E phase component comprises: 1-10% of butanediol, 0.01-0.2% of oat beta-glucan, 1-3% of betaine, 0.01-0.3% of baicalin, 0.01-0.3% of matrine, 0.01-0.5% of salicin, 0.01-0.1% of blackberry lily extract, 0.01-1% of dandelion extract, 0.1-0.8% of p-hydroxyacetophenone, 0.1-0.8% of 1, 2-hexanediol and the balance of deionized water.
The acne-removing microemulsion from natural sources has the greatest difference that in the published acne-removing patent, the invention adopts sucrose ester which is safe and mild from natural sources as an emulsifier of the microemulsion and a special production process, and the prepared acne-removing microemulsion from natural sources is semitransparent or transparent, has small particle size, has good absorption effect and quick acne-removing effect and achieves the effect of half the power of a medicine.
The present invention will be described in further detail below with reference to specific preferred examples and effect test examples, but the present invention is not limited to the following examples.
Examples 1 to 5
The acne-removing microemulsion with natural sources in the embodiments 1 to 5 is prepared from the raw material components shown in the table 1 in percentage by weight.
Table 1 compositions (% by weight) of the naturally derived anti-acne microemulsion formulations of examples 1-5
The preparation method comprises the following steps:
the preparation methods of the embodiments 1 to 5 are the same, and the raw materials are weighed according to the weight percentage and then carried out according to the following operation processes:
1) Adding all the components of the phase A into a reaction kettle, stirring (30 r/m), heating to 70-75 ℃, preserving heat for about 20 minutes, stirring (30 r/m) until the components are completely dissolved, adding all the components of the phase B, preserving heat for about 30 minutes at 55-60 ℃, stirring (30 r/m) until the components are completely dissolved, adding the components of the phase C, stirring (30 r/m), and heating to 55-60 ℃;
2) Slowly adding the phase D which is preheated to about 50 ℃ in advance while stirring (100 r/m) the mixture of the phase A, the phase B and the phase C prepared in the step 1) until all the phase D is added;
3) Adding all the components of phase E into a water kettle, stirring (30 r/m), heating to 80-85 deg.C, maintaining the temperature for about 20 min, stirring (30 r/m) until completely dissolved, and cooling to 50 deg.C for use;
4) Mixing the liquids prepared in the steps 2) and 3), and stirring (30 r/m) for 10 minutes to obtain the semitransparent bluish or transparent acne-removing microemulsion with natural sources.
Comparative examples 1 to 3
The acne-removing lotion of natural sources in comparative examples 1 to 3 is prepared from the raw material components shown in the table 2 in percentage by weight.
Table 2 composition of acne-removing lotion of natural origin in comparative examples 1-3 (% by weight)
The preparation method comprises the following steps:
the preparation methods of comparative examples 1 to 3 are the same, and the raw materials are weighed according to the weight percentage and then carried out according to the following operation processes:
1) Adding all the components of the phase A into a reaction kettle, stirring (30 r/m), heating to 70-75 ℃, preserving heat for about 20 minutes, stirring (30 r/m) until the components are completely dissolved, adding all the components of the phase B, preserving heat for about 30 minutes at 55-60 ℃, stirring (30 r/m) until the components are completely dissolved, and reserving for later use;
2) Adding all the components of phase C into a water kettle, stirring (30 r/m), heating to 80-85 deg.C, maintaining the temperature for about 20 min, stirring (30 r/m) until completely dissolved, and cooling to 60 deg.C;
3) Adding the liquid prepared in the step 1) into the liquid prepared in the step 2), mixing and homogenizing for 3 minutes, stirring (30 r/m), and cooling to below 40 ℃ to obtain pink emulsion, but not microemulsion.
Comparative examples 4 to 5
The acne-removing microemulsion with natural sources of comparative examples 4-5 is prepared from the raw material components shown in the table 3 in percentage by weight.
Table 3 composition of the microemulsion formulations for removing acne from natural sources of comparative examples 4-5 (% by weight)
The preparation method comprises the following steps:
the preparation methods of comparative examples 4 to 5 are the same, and the raw materials are weighed according to the weight percentage and then carried out according to the following operation processes:
1) Adding all the components of the phase A into a reaction kettle, stirring (30 r/m), heating to 70-75 ℃, preserving heat for about 20 minutes, stirring (30 r/m) until the components are completely dissolved, adding all the components of the phase B, preserving heat for about 30 minutes at 55-60 ℃, stirring (30 r/m) until the components are completely dissolved, adding the components of the phase C, stirring (30 r/m), and heating to 55-60 ℃;
2) Slowly adding the phase D which is preheated to about 50 ℃ in advance while stirring (100 r/m) the mixture of the phase A, the phase B and the phase C prepared in the step 1) until all the phase D is added;
3) Adding all the components of the phase E into a water kettle, stirring (30 r/m), heating to 80-85 ℃, keeping the temperature for about 20 minutes, stirring (30 r/m) until the components are completely dissolved, and then cooling to 50 ℃ for later use;
4) Mixing the liquids prepared in the steps 2) and 3), and stirring (30 r/m) for 10 minutes to obtain the semitransparent bluish or transparent acne-removing microemulsion with natural sources.
Examples of Effect test
1. Stability test
The acne-removing microemulsion with natural source prepared in the embodiments 1-5, the acne-removing microemulsion with natural source prepared in the comparative examples 1-3 and the acne-removing microemulsion with natural source prepared in the comparative examples 4-5 are subjected to heat resistance (48 ℃), cold resistance (-20 ℃) and heat resistance (48 ℃) and cold resistance (-20 ℃) alternation, and the results are shown in the following table 3:
TABLE 4 stability testing of examples 1-5 and comparative examples 1-5
As can be seen from Table 4, the anti-acne microemulsions of natural origin prepared in examples 1-5 and comparative examples 4-5 of the present invention have good stability by alternating heat resistance (48 ℃), cold resistance (-20 ℃) and heat resistance (48 ℃), cold resistance (-20 ℃), while the anti-acne microemulsions of natural origin prepared in comparative examples 1-3 have poor stability by alternating heat resistance (48 ℃) and heat resistance (48 ℃), and cold resistance (-20 ℃).
2. Use effect test (I)
And (3) testing the product: the acne removing microemulsion with natural source prepared in the example 1 and the acne removing emulsion with natural source prepared in the comparative example 1.
The testing personnel: selecting testers with the same number of whelks on the left side and the right side of the face and the same skin damage degree, wherein the testers only have acnes (slight): 40, papules, pustules (moderate): 28 persons, with nodules, cysts (severe): 20 persons.
The using method comprises the following steps: after cleaning the face every morning and evening, the tester takes a proper amount of the product to be uniformly smeared on the affected part and gently massages the product until the product is completely absorbed; the acne removing microemulsion prepared from the natural source in the example 1 on the left and the acne removing emulsion prepared from the natural source in the comparative example 1 on the right take 7 days as a treatment course, and 4 treatment courses are observed.
Evaluation standard of acne removing effect:
and (3) healing: the skin lesion is removed, the inflammation basically disappears, and the acne marks are lightened.
The effect is shown: the skin lesion is mostly removed, and the inflammation is obviously reduced. The method has the following advantages: the skin lesion is partially removed and the inflammation is improved.
And (4) invalidation: the skin lesions do not regress significantly or increase instead. The test results are given in table 5 below.
Table 5 test results using example 1 and comparative example 1
As can be seen from table 5, the acne removing effect of the acne removing microemulsion of natural origin prepared in example 1 of the present invention is significantly better than that of the acne removing microemulsion of natural origin prepared in comparative example 1. Example 1 and comparative example 1 have the same composition but different process, and example 1 produces a microemulsion with a small particle size: 5 nm-100 nm, so that the skin can be easily absorbed through skin; while comparative example 1 produced a common emulsion with a larger particle size: not less than 500nm, therefore, the absorption effect is poor and the acne removing effect is also poor.
3. Use effect test 2
And (3) testing the product: the acne removing microemulsion with natural source prepared in the embodiment 4 and the acne removing microemulsion with natural source prepared in the comparative example 4.
The testing personnel: 100 pox patients (including acne, pimple, pustule, nodule, cyst) were selected, and half of men and women (50 men and women). The groups are randomly divided into two groups A and B, and the male and the female are respectively half (25 cases for both male and female).
The using method comprises the following steps: after cleaning face every morning and evening, the tester takes a proper amount of the product and uniformly applies the product to the affected part, and gently massages the product until the product is completely absorbed; group A uses the microemulsion prepared from the natural source in example 4, group B uses the microemulsion prepared from the natural source in comparative example 4, 7 days is a treatment course, and 4 treatment courses are observed.
Evaluation standard of acne removing effect:
and (3) healing: the skin lesion is removed, the inflammation basically disappears, and the acne marks are lightened.
The effect is shown: the skin lesion is mostly removed, and the inflammation is obviously reduced.
The method has the following advantages: the skin lesion is partially removed and the inflammation is improved.
And (4) invalidation: the skin lesions do not regress significantly or increase instead.
The test results are shown in table 6 below.
Table 6 test results using example 4 and comparative example 4
As can be seen from table 6, the acne removing effect of the acne removing microemulsion of natural origin prepared in example 4 of the present invention is significantly better than that of the acne removing microemulsion of natural origin prepared in comparative example 4.
Example 4 contains essential oils:
1) Can disturb the highly ordered intercellular lipid structure between the keratinocytes in the stratum corneum;
2) Can interact with intercellular structure domain of protein to induce its conformation change, so that stratum corneum is more permeable; the drug distribution can be increased.
Therefore, the traditional Chinese medicine extract can be promoted to permeate, and the acne removing effect is better.
As described above, the present invention is only a preferred embodiment, and is not limited in any way, and therefore, any simple modification, equivalent change and modification of the above embodiment according to the technical essence of the present invention will still fall within the scope of the technical solution of the present invention.
Claims (9)
1. The acne-removing microemulsion from natural sources is characterized by being prepared from the following raw materials in percentage by weight:
0.01-0.1% of alkannin, 0.01-0.2% of tanshinone II, 0.01-0.2% of licochalcone A, 0.01-0.5% of baicalin, 0.01-0.5% of paeonol, 0.01-0.5% of matrine, 0.01-0.5% of salicin, 0.01-0.5% of clove oil, 0.01-0.5% of thyme essential oil, 0.01-1% of rosemary essential oil, 0.01-1% of lavender essential oil, 0.01-1% of blackberry lily extract, 0.01-1% of dandelion extract, 0.1-2% of tocopherol acetate, 1-5% of sucrose ester, 1-15% of glycerol, 1-10% of butanediol, 0.01-0.2% of oat beta-glucan, 1-3% of betaine, 0.1-0.8% of p-hydroxy-phenyl ethyl ketone, 0.1-0.8% of 1, 2-hexanediol and the balance of deionized water.
2. The naturally derived acne-removing microemulsion of claim 1 wherein: the material is prepared from the following raw materials in percentage by weight:
0.01-0.04% of alkannin, 0.04-0.06% of tanshinone II, 0.01-0.05% of licochalcone A, 0.01-0.3% of baicalin, 0.1-0.3% of paeonol, 0.01-0.25% of matrine, 0.1-0.3% of salicin, 0.01-0.2% of clove oil, 0.01-0.3% of thyme essential oil, 0.01-0.8% of rosemary essential oil, 0.01-0.9% of lavender essential oil, 0.1-0.25% of blackberry lily extract, 0.1-0.3% of dandelion extract, 1.2-1.6% of tocopherol acetate, 4-4.5% of sucrose ester, 8-10% of glycerol, 4-6% of butanediol, 0.03-0.1% of oat beta-glucan, 1-2.5% of betaine, 0.2-0.7% of p-hydroxyacetophenone, 1, 0.2-0.7% of 2-hexanediol and the balance of deionized water.
3. The naturally derived acne-removing microemulsion of claim 1 wherein: the sucrose ester is one or more of sucrose poly-cotton seed oleate, sucrose stearate and sucrose laurate which are natural sources.
4. The naturally derived acne-removing microemulsion of claim 1 wherein:
1-15% of glycerin, 1-10% of butanediol, 0.01-0.2% of oat beta-glucan and 1-3% of betaine, and is used as a humectant with moistening and moisturizing effects.
5. The naturally derived acne-removing microemulsion of claim 1 wherein: 0.1-0.8% of p-hydroxyacetophenone and 0.1-0.8% of 1, 2-hexanediol are used as preservatives with antiseptic effect.
6. An acne-removing microemulsion of natural origin, characterized in that: the composition is prepared from the following phase A component, phase B component, phase C component, phase D component and phase E component in percentage by weight:
the phase A component comprises: 1-5% of sucrose ester and 0.1-2% of tocopherol acetate;
the phase B component comprises: 0.01 to 0.1 percent of alkannin, 0.01 to 0.2 percent of tanshinone II, 0.01 to 0.2 percent of licochalcone A, 0.01 to 0.5 percent of paeonol, 0.01 to 0.5 percent of clove oil, 0.01 to 0.5 percent of thyme essential oil, 0.01 to 1 percent of rosemary essential oil and 0.01 to 1.0 percent of lavender essential oil;
the phase C component comprises: 1-15% of glycerol;
the phase D component comprises: 10-20% of deionized water;
the phase E component comprises: 1-10% of butanediol, 0.01-0.2% of oat beta-glucan, 1-3% of betaine, 0.01-0.5% of baicalin, 0.01-0.5% of matrine, 0.01-0.5% of salicin, 0.01-0.1% of blackberry lily extract, 0.01-1% of dandelion extract, 0.1-0.8% of p-hydroxyacetophenone, 0.1-0.8% of 1, 2-hexanediol and the balance of deionized water.
7. The process for the preparation of an anti-acne microemulsion of natural origin according to claim 6, characterized in that: weighing the raw materials according to the weight percentage, and then carrying out the following operation processes:
1) Adding all the components of the phase A into a reaction kettle, stirring and heating to 70-75 ℃, preserving heat for 20 minutes, stirring until the components are completely dissolved, adding all the components of the phase B, preserving heat for 30 minutes at 55-60 ℃, stirring until the components are completely dissolved, adding the components of the phase C, stirring and heating to 55-60 ℃;
2) Slowly adding the phase D which is preheated to 50 ℃ while stirring the mixture (A phase, B phase and C phase) prepared in the step 1) until all the phase D is added;
3) Adding all the components of the phase E into a water kettle, stirring and heating to 80-85 ℃, preserving heat for 20 minutes, stirring until the components are completely dissolved, and then cooling to 50 ℃ for later use;
4) Mixing the liquids prepared in the steps 2) and 3), and stirring for 10 minutes to obtain the acne-removing microemulsion from natural sources.
8. The process for preparing an anti-acne microemulsion of natural origin according to claim 7, characterized in that: in the step 1), the stirring speed is 30r/m; in the step 2), the stirring speed is 100r/m; in the step 3), the stirring speed is 30r/m; in step 4), the stirring rate was 30r/m.
9. The process for the preparation of an anti-acne microemulsion of natural origin according to claim 7, characterized in that: in the step 4), the acne-removing microemulsion from natural sources is in a semitransparent bluish or transparent color.
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