CN113616575A

CN113616575A - Composite azelaic acid emulsion for preventing allergy and removing acne and preparation method thereof

Info

Publication number: CN113616575A
Application number: CN202111085162.6A
Authority: CN
Inventors: 鲍丰祺; 顾敏; 蔡蓓蕾
Original assignee: Jiangsu Zhiyuan Pharmaceutical Co ltd
Current assignee: Jiangsu Zhiyuan Pharmaceutical Co ltd
Priority date: 2021-09-16
Filing date: 2021-09-16
Publication date: 2021-11-09

Abstract

The invention discloses a composite azelaic acid emulsion for preventing allergy and removing acne and a preparation method thereof, wherein the functional components comprise the following raw materials in parts by mass: 10-20 parts of azelaic acid, 0.5-2 parts of salicylic acid, 0.1-1 part of tranexamic acid, 0.1-1 part of bisabolol, 0.1-1 part of hamamelis water, 0.1-1 part of purslane extract and 0.1-1 part of soyasterol. The emulsion composition disclosed by the invention can be well absorbed through the skin surface layer, and the components are matched according to a specific proportion, so that the emulsion composition is rich in multiple functional components which are mutually synergistic, can soften cutin, refine pores, inhibit bacteria, diminish inflammation, resist irritation, balance grease, relieve blackhead and acne marks, and has excellent anti-allergy, soothing, acne-removing and skin-care effects.

Description

Composite azelaic acid emulsion for preventing allergy and removing acne and preparation method thereof

Technical Field

The invention relates to azelaic acid emulsion and a preparation method thereof, in particular to composite azelaic acid emulsion for preventing allergy and removing acne and a preparation method thereof.

Background

The acne is commonly known as acne, also called as whelk, pimple or comedo, and is a skin disease caused by the blockage and inflammation of hair follicles and sebaceous glands. Although the disease generally does not affect the overall health of the patient, the disease usually brings a heavy mental burden to the patient because the disease is better at the face and other parts and scars which are harmful to the appearance are left if the disease is not treated in time.

Azelaic acid, also known as azelaic acid, is a complex molecule with multiple activities, and with continuous knowledge of clinical application, the anti-inflammatory, anti-infection and antibacterial effects of azelaic acid are discovered and proved. At present, azelaic acid is widely used in the treatment of acne, melanoma, chloasma, rosacea, hyperpigmentation and sclerosis. Azelaic acid has been shown to modulate the inflammatory response of normal human keratinocytes through several pathways, including modulation of the signaling pathways of peroxisome proliferator activated receptor g and nuclear factor (nuclear factor b) NF-KB, regulation of cytokines TNF-a, IL-1, IL-6, etc., which are associated with immune responses, and inhibition of proinflammatory cytokine secretion was observed.

The salicylic acid is a fat-soluble organic acid, can improve the skin and accelerate the metabolism of the skin, is a natural substance capable of removing sebum cutin, can increase the cell regeneration of the skin, keep the skin smooth and delicate, can also shrink pores, can relieve the blockage of the skin pores in life by using the salicylic acid, effectively prevents the occurrence of whelk, and has the function of cleaning the hair follicles.

Tranexamic acid is used as a skin conditioner, a moisturizer and a whitening agent in cosmetics. It has the factor group for inhibiting melanin enhancement, thereby completely blocking the melanin formation path due to ultraviolet irradiation, preventing the black spot from thickening and enlarging, and effectively preventing skin pigmentation.

The bisabolol is extracted from chrysanthemum plants, has the functions of resisting inflammation and inhibiting bacteria, has good stability, has high permeability in skin cortex which is dozens of times of common penetrant, has good compatibility with skin, can reduce skin inflammation, relieve skin acne, prevent acne from generating, improve the anti-irritation capability of the skin and repair the skin with inflammation injury.

The Hamamelis virginiana extract has effects of resisting oxidation, increasing topical estrogen level of cortex, enhancing skin cell metabolism, resisting aging, maintaining skin elasticity and resisting wrinkle; has antiinflammatory, antiallergic, soothing and astringent effects; and simultaneously has good water holding capacity.

The herba Portulacae extract has broad-spectrum antibacterial and antiinflammatory effects, and can be used for preventing and treating dermatoses such as skin eczema, allergic dermatitis, and contact skin; has good oxygen free radical scavenging ability and obvious antioxidation function; has good skin moisture keeping effect.

The wild soybean sterols are derived from wild soybean, and are helpful for maintaining lamellar lipid structure between corneocytes in stratum corneum, and effectively locking water, thereby helping damaged skin recover natural barrier function, improving membrane fluidity and elasticity, resisting external stimulation, improving water balance, reducing inflammation, and promoting healing.

After a considerable amount of research work in the field of cosmetics containing azelaic acid, it was found in the art that the products are partly slow to work and have varying degrees of skin irritation during use.

Disclosure of Invention

The invention aims to provide the composite azelaic acid emulsion for preventing allergy and removing acnes and the preparation method thereof, the emulsion composition can well permeate the surface layer of skin to be absorbed, the components are matched according to a specific proportion, and the emulsion composition is rich in a plurality of functional components which are mutually synergistic, can soften cutin, refine pores, inhibit bacteria and diminish inflammation, resist irritation, balance grease, relieve blackhead and acne marks, has excellent effects of preventing allergy, relieving itching, removing acnes and protecting skin, and can solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

a composite azelaic acid emulsion for preventing allergy and removing acne comprises effective components and adjuvant components;

the functional components comprise the following raw materials in parts by mass: 10-20 parts of azelaic acid, 0.5-2 parts of salicylic acid, 0.1-1 part of tranexamic acid, 0.1-1 part of bisabolol, 0.1-1 part of hamamelis water, 0.1-1 part of purslane extract and 0.1-1 part of soyasterol;

the auxiliary material components comprise the following raw materials in parts by mass: 3-8 parts of butanediol, 2-3 parts of glycerol, 1-5 parts of polydimethylsiloxane, 210.5-1 parts of steareth, 0.5-1 part of propylene glycol, 0.5-1 part of caprylic/capric triglyceride, 0.1-0.6 part of carbomer, 0.001-0.007 part of methylparaben, 0.1-1 part of hydrogenated lecithin, 20.1-1 parts of steareth, 0.1-0.25 part of sodium hydroxide, 0.1-0.3 part of disodium EDTA (ethylene diamine tetraacetic acid), 0.1-0.3 part of benzoic acid and the balance of water.

Further, the functional components comprise the following raw materials in parts by mass: 15 parts of azelaic acid, 1 part of salicylic acid, 0.5 part of tranexamic acid, 0.5 part of bisabolol, 0.5 part of hamamelis water, 0.5 part of purslane extract and 0.5 part of wild soybean sterol; the auxiliary material components comprise the following raw materials in parts by mass: 6 parts of butanediol, 4 parts of glycerol, 4 parts of polydimethylsiloxane, 211 parts of steareth-211, 1 part of propylene glycol, 1 part of caprylic/capric triglyceride, 0.4 part of carbomer, 0.005 part of methyl hydroxybenzoate, 0.5 part of hydrogenated lecithin, 20.5 parts of steareth-20.25 parts of sodium hydroxide, 0.1 part of disodium EDTA, 0.1 part of benzoic acid and the balance of water.

The invention also provides another technical scheme: a preparation method of composite azelaic acid emulsion for preventing allergy and removing acne comprises the following steps:

s1: mixing and homogenizing: putting water, EDTA disodium, steareth-21, steareth-2 and benzoic acid into an emulsifying pot, heating to 70-75 ℃, stirring for 20-30 rpm, stirring for 5-10 minutes, homogenizing for 2200 rpm and 2500 rpm, and homogenizing for 5-10 minutes until the components are uniformly dispersed;

s2: emulsification: keeping the temperature at 70-75 ℃, putting butanediol, glycerol, propylene glycol, polydimethylsiloxane, caprylic/capric triglyceride, hydrogenated lecithin and wild soybean sterol into an emulsifying pot, homogenizing for 5-10 minutes at 2200-;

s3: primary dispersion: cooling to 60-65 deg.C, adding carbomer into emulsifying pot, stirring for 20-30 r/min for 5-10 min, homogenizing for 2200 r/min and 2500 r/min for 5-10 min, and dispersing uniformly;

s4: and (3) secondary dispersion: cooling to 40 deg.C, adding azelaic acid, salicylic acid, tranexamic acid, bisabolol, hamamelis water and herba Portulacae extract into emulsifying pot, stirring for 20-30 r/min and 5-10 min, homogenizing for 2200 r/min and 2500 r/min, homogenizing for 10-20 min, and dispersing uniformly;

s5: and (3) dispersing for three times: keeping the temperature at 40 ℃, adding the pre-dissolved sodium hydroxide into an emulsifying pot, stirring for 20-30 r/min, and stirring for 5-10 minutes until the sodium hydroxide is uniformly dispersed;

s6: inspecting and filling: when the temperature is below 38 ℃, sampling and inspecting, discharging after the semi-finished product is qualified, and filling to obtain the composite azelaic acid emulsion.

Further, the obtained composite azelaic acid emulsion is used for preventing allergy and removing acne.

Further, the use method of the composite azelaic acid emulsion comprises the following steps: after the face cleaning cream is adopted to clean the dirt on the face, the composite azelaic acid emulsion is evenly smeared on the face whelk, and the face is massaged for 3-5 minutes and then absorbed by the face whelk.

Compared with the prior art, the invention has the beneficial effects that:

the main components of the composite azelaic acid emulsion provided by the invention are azelaic acid, salicylic acid, tranexamic acid, bisabolol, hamamelis water, purslane extract and wild soybean sterol, and the composite azelaic acid emulsion can well permeate the surface layer of the skin to be absorbed, is rich in various functional components which are cooperated with each other according to a specific proportion, can soften cutin, refine pores, inhibit bacteria and diminish inflammation, resist irritation, balance grease, relieve blackhead closure and acne marks, and has excellent effects of preventing allergy, relieving, removing acne and protecting the skin.

Drawings

FIG. 1 is a flow chart of the preparation process of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

the functional components comprise the following raw materials in parts by mass: 10-20 parts of azelaic acid, 0.5-2 parts of salicylic acid, 0.1-1 part of tranexamic acid, 0.1-1 part of bisabolol, 0.1-1 part of hamamelis water, 0.1-1 part of purslane extract and 0.1-1 part of soyasterol.

The invention is illustrated by the following examples:

example 1

1000g of emulsion were prepared using the following materials:

。

as shown in fig. 1, the preparation process comprises the following steps:

(1) 551.45g of water, 1g of disodium EDTA, 2110 g of steareth-2110 g, 25 g of steareth-25 g and 1g of benzoic acid are put into an emulsifying pot, heated to 70-75 ℃, stirred for 5-10 minutes at 20-30 rpm, homogenized for 2200 rpm and 5-10 minutes until the mixture is uniformly dispersed.

(2) Keeping the temperature at 70-75 ℃, putting 60g of butanediol, 40g of glycerol, 10g of propylene glycol, 40g of polydimethylsiloxane, 10g of caprylic acid/capric acid triglyceride, 5g of hydrogenated lecithin and 5g of wild soybean sterol into an emulsifying pot, homogenizing for 5-10 minutes at 2200 rpm, stirring for 20-30 rpm, and stirring for 5-10 minutes until the emulsification is uniform.

(3) Cooling to 60-65 deg.C, adding carbomer 4g into emulsifying pot, stirring at 20-30 rpm for 5-10 min, homogenizing at 2200 rpm and 2500 rpm for 5-10 min, and dispersing uniformly.

(4) Cooling to 40 deg.C, adding azelaic acid 150g, salicylic acid 10g, tranexamic acid 5g, bisabolol 5g, Hamamelis virginiana water 5g, and herba Portulacae extract 5g into emulsifying pot, stirring at 20-30 rpm for 5-10 min, homogenizing at 2200 rpm and 2500 rpm, and homogenizing for 10-20 min until uniformly dispersed.

(5) Preserving the temperature at 40 ℃, adding pre-dissolved sodium hydroxide/water (2.5 g/50 g) into an emulsifying pot, stirring for 20-30 r/min, and stirring for 5-10 min until the mixture is uniformly dispersed.

(6) When the temperature is below 38 ℃, sampling and inspecting, discharging after the semi-finished product is qualified, and filling to obtain the product.

Example 2

1000g of emulsion were prepared using the following materials:

。

the preparation process comprises the following steps:

(1) 634.49g of water, 3g of disodium EDTA, 215 g of steareth, 21 g of steareth and 1g of benzoic acid are put into an emulsifying pot, heated to 70-75 ℃, stirred for 5-10 minutes at 20-30 rpm, homogenized for 2200 rpm and 5-10 minutes until the mixture is uniformly dispersed.

(2) Keeping the temperature at 70-75 ℃, putting 80g of butanediol, 30g of glycerol, 10g of propylene glycol, 50g of polydimethylsiloxane, 10g of caprylic acid/capric acid triglyceride, 1g of hydrogenated lecithin and 1g of wild soybean sterol into an emulsifying pot, homogenizing for 5-10 minutes at 2200 rpm, stirring for 20-30 rpm, and stirring for 5-10 minutes until the emulsification is uniform.

(4) Cooling to 40 deg.C, adding 100g azelaic acid, 20g salicylic acid, 1g tranexamic acid, 10g bisabolol, 1g Hamamelis virginiana water and 10g herba Portulacae extract into emulsifying pot, stirring at 20-30 rpm for 5-10 min, homogenizing at 2200 rpm and 2500 rpm for 10-20 min, and dispersing uniformly.

Example 3

1000g of emulsion were prepared using the following materials:

。

the preparation process comprises the following steps:

(1) 612.93g of water, 1g of disodium EDTA, 2110 g of steareth-2110 g, 210 g of steareth-210 g and 3g of benzoic acid are put into an emulsifying pot, heated to 70-75 ℃, stirred for 5-10 minutes at 20-30 rpm, homogenized for 2200 rpm and 5-10 minutes until the mixture is uniformly dispersed.

(2) Keeping the temperature at 70-75 ℃, putting 30g of butanediol, 20g of glycerol, 5g of propylene glycol, 10g of polydimethylsiloxane, 5g of caprylic acid/capric acid triglyceride, 10g of hydrogenated lecithin and 10g of wild soybean sterol into an emulsifying pot, homogenizing for 5-10 minutes at 2200 rpm, stirring for 20-30 rpm and stirring for 5-10 minutes until the emulsification is uniform.

(3) Cooling to 60-65 deg.C, adding carbomer 1g into emulsifying pot, stirring at 20-30 rpm for 5-10 min, homogenizing at 2200 rpm and 2500 rpm for 5-10 min, and dispersing uniformly.

(4) Cooling to 40 deg.C, adding azelaic acid 200g, salicylic acid 5g, tranexamic acid 10g, bisabolol 1g, Hamamelis virginiana water 10g, and herba Portulacae extract 10g into emulsifying pot, stirring at 20-30 rpm for 5-10 min, homogenizing at 2200 rpm and 2500 rpm, and homogenizing for 10-20 min until uniformly dispersed.

(5) Preserving the temperature at 40 ℃, adding pre-dissolved sodium hydroxide/water (1 g/100 g) into an emulsifying pot, stirring for 20-30 r/min, and stirring for 5-10 min until the mixture is uniformly dispersed.

The comparative example is a conventional azelaic acid emulsion.

Testing the efficacy of the composite azelaic acid emulsion:

in order to verify the efficacy of the present invention in removing acne, the following experiments were performed.

Summary of test methods:

80 volunteers are selected for the research, the ages of the 80 volunteers are 19-30 years old, cosmetics can be used according to the standard, the evaluation work can be completed according to requirements by matching with workers, the facial mask has certain expression capability and can truly reflect the feeling after use, and the tested part is the face and is respectively applied to the affected part for 1 time in the morning and evening. The test time was 7 days. 80 volunteers were divided into 4 groups including 3 experimental groups and 1 control group, the 3 experimental groups were respectively designated as group A, group B and group C, and the control group was group D.

Evaluation criteria:

(1) the acne removing effect is as follows: obvious effect, effective and ineffective. Wherein the substantial elimination of whelk is judged to be significant effect; partial acne elimination is judged to be effective; acne is not reduced or is not significantly reduced and is judged to be ineffective.

Anti-allergy and relieving effects: good, general, bad. Wherein abnormal stinging, burning, itching, erythema or more severe reaction is judged to be poor; mild itching or tingling sensation was judged as normal; no obvious discomfort was judged to be good.

Table 1: results of the experiment

。

The test results in table 1 show that, when the composite azelaic acid emulsion of the invention is used for 7 days in the experimental group ABC, the total effective rate (effective + effective) is more than 95% in the acne removing effect aspect, the effective rate is more than 50%, the ineffective rate is 0, the good evaluation rate is more than 77% and the poor evaluation rate is 0 in the allergy prevention and relief effect aspect, and when the common azelaic acid emulsion is used in the comparative group D, the total effective rate (effective + effective) is only 28.75% in the acne removing effect aspect, the ineffective rate is 55%, the good evaluation rate is only more than 3.75% and the poor evaluation rate is 72.5% in the allergy prevention and relief effect aspect, so that the composite azelaic acid emulsion of the invention has excellent allergy prevention and relief, acne removal and skin care effects and is approved by most subjects.

In addition, the experimental group ABC and the comparative group D were subjected to microbiological examination, and the results were as follows:

table 2: results of microbiological examination

。

As can be seen from Table 2, the composite azelaic acid emulsion of the experimental group ABC is far smaller than the limit values on the total number of bacterial colonies, the total number of moulds and yeasts after the microbial examination, and heat-resistant coliform groups, staphylococcus aureus and pseudomonas aeruginosa are not detected, while the common azelaic acid emulsion of the comparative group D has the limit values on the total number of bacterial colonies, the total number of moulds and yeasts and trace detection of heat-resistant coliform groups, staphylococcus aureus and pseudomonas aeruginosa, which shows that the composite azelaic acid emulsion of the invention can soften cutin, refine pores, inhibit bacteria, diminish inflammation, resist irritation, balance grease, and relieve blackhead closure and acne marks.

Through researching the known specific acne-removing raw materials and combining the materials in a very determined range in proportion, the composite azelaic acid emulsion has obvious synergistic action, permeability and anti-irritation capability, and has obviously improved anti-allergy soothing and acne-removing effects.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the technical solutions and the inventive concepts of the present invention within the technical scope of the present invention.

Claims

1. The composite azelaic acid emulsion for preventing allergy and removing acne is characterized by comprising functional components and auxiliary material components;

2. The composite azelaic acid emulsion for preventing allergy and removing acne as claimed in claim 1, wherein the functional ingredients comprise the following raw materials in parts by mass: 15 parts of azelaic acid, 1 part of salicylic acid, 0.5 part of tranexamic acid, 0.5 part of bisabolol, 0.5 part of hamamelis water, 0.5 part of purslane extract and 0.5 part of wild soybean sterol; the auxiliary material components comprise the following raw materials in parts by mass: 6 parts of butanediol, 4 parts of glycerol, 4 parts of polydimethylsiloxane, 211 parts of steareth-211, 1 part of propylene glycol, 1 part of caprylic/capric triglyceride, 0.4 part of carbomer, 0.005 part of methyl hydroxybenzoate, 0.5 part of hydrogenated lecithin, 20.5 parts of steareth-20.25 parts of sodium hydroxide, 0.1 part of disodium EDTA, 0.1 part of benzoic acid and the balance of water.

3. The preparation method of the composite azelaic acid emulsion for preventing allergy and acne in claim 1, which comprises the following steps:

4. The method for preparing the composite azelaic acid emulsion for preventing allergy and removing acne as claimed in claim 3, wherein the obtained composite azelaic acid emulsion is used for preventing allergy and removing acne.

5. The preparation method of the composite azelaic acid emulsion for preventing allergy and removing acne as claimed in claim 4, wherein the composite azelaic acid emulsion is used by the following method: after the face cleaning cream is adopted to clean the dirt on the face, the composite azelaic acid emulsion is evenly smeared on the face whelk, and the face is massaged for 3-5 minutes and then absorbed by the face whelk.