CN112294715A - Composition with acne removing and repairing effects, skin care preparation and preparation method of skin care preparation - Google Patents
Composition with acne removing and repairing effects, skin care preparation and preparation method of skin care preparation Download PDFInfo
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- CN112294715A CN112294715A CN201910700908.6A CN201910700908A CN112294715A CN 112294715 A CN112294715 A CN 112294715A CN 201910700908 A CN201910700908 A CN 201910700908A CN 112294715 A CN112294715 A CN 112294715A
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- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 51
- 206010000496 acne Diseases 0.000 title claims abstract description 51
- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 42
- 230000000694 effects Effects 0.000 title claims abstract description 37
- 239000002994 raw material Substances 0.000 claims abstract description 26
- 229920002101 Chitin Polymers 0.000 claims abstract description 23
- 239000000284 extract Substances 0.000 claims abstract description 15
- 240000006240 Linum usitatissimum Species 0.000 claims abstract description 4
- 235000004431 Linum usitatissimum Nutrition 0.000 claims abstract description 4
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- 238000003756 stirring Methods 0.000 claims description 25
- 238000010438 heat treatment Methods 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 21
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- 241001673966 Magnolia officinalis Species 0.000 claims description 5
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 5
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- 239000001575 punica granatum l. bark extract Substances 0.000 claims description 3
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- 235000005412 red sage Nutrition 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 24
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- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 description 1
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- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229940107657 flaxseed extract Drugs 0.000 description 1
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- 210000001061 forehead Anatomy 0.000 description 1
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- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
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- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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- Dermatology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Biotechnology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Botany (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A composition with acne removing and repairing functions, a skin care preparation and a preparation method thereof relate to skin care products. The composition with the acne removing and repairing effects comprises the following raw materials in percentage by weight: 0.5-3.0 wt% of acne-removing efficacy composition, 0.5-1.0 wt% of linseed extract and 0.02-0.5 wt% of chitin. The composition with the acne removing effect provided by the invention forms a good repairing environment for relieving, removing acne and controlling oil, achieves the effects of synergy and effectively repairing sensitive acne skin.
Description
Technical Field
The present invention relates to personal care products, and in particular to skin care products.
Background
As is well known, the "color age" has been entered, more and more people need to try different skin care products, color cosmetics, makeup removers and other products every day, and the huge working pressure and the skin pressure caused by the deterioration of the environment are added, and more teenagers and adults are simultaneously troubled by the sensitivity and the acne, which have different degrees of influence on the life, the work, the psychological confidence, the social interaction and the like of the teenagers and the adults. Therefore, the composition and the preparation with the effective skin-soothing, acne-removing and repairing effects have very important significance and market prospect.
Although many herbal-effective compositions have emerged specifically for caring for pox skin, they mostly inhibit propionibacterium acnes, oil-controlling grease secretion, etc. by a single mechanism; some compounded functional compositions can perform the synergistic effect of inhibiting bacteria, controlling oil and removing acnes through a plurality of mechanism targets, obtain good effect in caring the acne skin, but the effect is difficult to show for more and more sensitive acne skin.
How to combine the complex generation mechanism and skin expression of sensitive skin and acne skin, design and develop a more effective compound effect composition, and can achieve the effects of improving skin inflammation, repairing damaged barriers and removing acnes for a long time, which is a technical problem in the field of skin care research at present.
Disclosure of Invention
The invention aims to provide an acne-removing and repairing composition to solve the technical problems.
The invention also aims to provide the composition with the acne-removing and repairing effects.
The invention aims to provide a method for preparing an acne-removing repairing effect composition skin care preparation so as to prepare the acne-removing repairing effect composition skin care preparation.
The technical problem solved by the invention can be realized by adopting the following technical scheme:
the composition with the acne-removing and repairing effects is characterized by comprising the following raw materials in percentage by weight:
0.5-3.0 wt% of acne-removing efficacy composition;
0.5-1.0 wt% of linseed extract;
0.02-0.5 wt% of chitin.
The acne-removing composition is rich in active substances such as plant flavone, polyphenol, micromolecular plant acid and the like, and can effectively inhibit inflammatory factors/mediators, inhibit 5-alpha reductase, dredge pores, correct pore dyskeratosis and the like, so that the effects of diminishing inflammation, controlling oil and removing acnes are achieved; the linseed extract is rich in plant polypeptide, can help skin to optimize the synthesis of antibacterial peptide per se, form a natural microbial community, stop pathogenic bacteria and maintain the balance of a sensitive pox skin microbial community ecosystem; meanwhile, the micromolecular chitin can obviously reduce the levels of interleukin-6 and TNF-alpha, so that the effect of relieving skin inflammation is achieved, meanwhile, the micromolecular chitin has the property of chelating metal ions, the tolerance and the using amount of the acne-removing composition on the skin with damaged skin barriers are improved, the better acne-removing effect is achieved, the small molecule chitin and the acne-removing composition are synergistic, and the skin-care effects of relieving sensitive skin, controlling oil, inhibiting bacteria and removing acnes are achieved.
The composition with the acne removing effect is preferably selected from a salvia miltiorrhiza extract, a magnolia bark extract, a pomegranate peel extract, a scutellaria baicalensis root extract and the like. Either one or a combination of two or more thereof. Further preferably contains extracts of Saviae Miltiorrhizae radix, cortex Magnolia officinalis and Salix alba.
The chitin is small molecular chitin, preferably small molecular chitin with molecular weight below 2 ten thousand daltons.
The flax seed extract is rich in plant polypeptides, the active substance of which is designated as protein.
The composition skin care preparation with the acne removing and repairing effects is characterized by comprising a component A, a component B and a component C;
wherein, the component A at least comprises the following raw materials in percentage by weight:
the component B at least comprises the following raw materials in percentage by weight:
the component C at least comprises the following raw materials in percentage by weight:
the raw materials of the acne-removing repairing effect composition and the acne-removing repairing effect composition skin care preparation are conventional raw materials, are convenient to obtain, and the preparation method is convenient, feasible, easy to popularize in a large scale and in a standardized manner, easy to accept by wide consumers, and good in application prospect and market prospect.
The method for preparing the acne-removing and repairing composition skin care preparation is characterized by comprising the following steps:
(1) weighing the component A materials in advance, soaking the components in an emulsifying preparation pot in advance until the components are completely wetted, sequentially adding the component A materials, homogenizing and dispersing uniformly, starting stirring and heating, heating to 80-85 ℃, keeping the temperature and stirring for 8-12 minutes for later use, and preferably stirring for 10 minutes;
(2) weighing the component B in advance, putting the component B into an oil pan, starting stirring and heating, pumping the mixture to an emulsifying preparation pan after heating to 60-70 ℃, keeping the temperature at 70-75 ℃, starting cooling after high-speed homogenization is carried out for 8-15 minutes, and preferably carrying out high-speed homogenization for 10 minutes;
(3) cooling to 45 ℃, wetting the chitin to be uniform by using pentanediol in advance for later use, adding the component C material, homogenizing at a low speed for 5 minutes, stirring (40 revolutions per minute) for 20 minutes, detecting the pH value of the material body after uniform mixing, and discharging the material through a 200-mesh screen after the pH value is qualified.
The composition with the acne-removing and repairing effects can be widely applied to common cosmetic formulations such as aqua, facial mask, cream and the like. The recommended use method comprises the following steps: after the face is cleaned every day, the face is smeared on the skin and is gently massaged and completely absorbed. The preparation of the invention is fresh and easy to absorb, and can be used for a plurality of times every day.
Detailed Description
In order to make the technical means, the creation features, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Example 1:
raw materials and proportion:
the component A comprises:
and B component:
the component C at least comprises the following raw materials in percentage by weight:
the preparation method comprises the following steps:
(1) weighing the component A materials in advance, soaking the components in an emulsifying preparation pot in advance until the components are completely wetted, sequentially adding the component A materials, homogenizing and dispersing the components uniformly, starting stirring and heating, heating to 80-85 ℃, and then preserving the temperature and stirring for 10 minutes;
(2) weighing the component B in advance, putting the component B into an oil pan, stirring and heating the component B, pumping the component B into an emulsifying preparation pan after heating the component B to 70-80 ℃, preserving the heat of the component B at 70-75 ℃, and homogenizing the component B for 10 minutes at a high speed;
(3) cooling to 45 ℃, adding the component C, slowly homogenizing for 3-6 minutes, preferably slowly homogenizing for 5 minutes, stirring (40 revolutions per minute) for 15-25 minutes, preferably 20 minutes, detecting the pH value of the material body after uniform mixing, and discharging through a 200-mesh screen after the pH value is qualified.
Example 2:
raw materials and proportion:
the component A comprises:
and B component:
the component C at least comprises the following raw materials in percentage by weight:
the preparation method comprises the following steps:
(1) weighing the component A materials in advance, soaking the components in an emulsifying preparation pot in advance until the components are completely wetted, sequentially adding the component A materials, homogenizing and dispersing the components uniformly, starting stirring and heating, heating to 80-85 ℃, and then preserving the temperature and stirring for 10 minutes;
(2) weighing the component B in advance, putting the component B into an oil pan, stirring and heating the component B, pumping the component B into an emulsifying preparation pan after heating the component B to 70-80 ℃, preserving the heat of the component B at 70-75 ℃, and homogenizing the component B for 10 minutes at a high speed;
(3) cooling to 45 ℃, wetting the chitin with pentanediol in advance until the chitin is uniform for later use, adding the component C, slowly homogenizing for 3-6 minutes, preferably slowly homogenizing for 5 minutes, stirring (40 revolutions per minute) for 15-25 minutes, preferably 20 minutes, detecting the pH value of a material body after uniform mixing, and discharging through a 200-mesh screen after the pH value is qualified.
Example 3:
raw materials and proportion:
the component A comprises:
and B component:
the component C at least comprises the following raw materials in percentage by weight:
the preparation method comprises the following steps:
(1) weighing the component A materials in advance, soaking the components in an emulsifying preparation pot in advance until the components are completely wetted, sequentially adding the component A materials, homogenizing and dispersing the components uniformly, starting stirring and heating, heating to 80-85 ℃, and then preserving the temperature and stirring for 10 minutes;
(2) weighing the component B in advance, putting the component B into an oil pan, stirring and heating the component B, pumping the component B into an emulsifying preparation pan after heating the component B to 70-80 ℃, preserving the heat of the component B at 70-75 ℃, and homogenizing the component B for 10 minutes at a high speed;
(3) cooling to 45 ℃, wetting the chitin with pentanediol in advance until the chitin is uniform for later use, adding the component C, slowly homogenizing for 3-6 minutes, preferably slowly homogenizing for 5 minutes, stirring (40 revolutions per minute) for 15-25 minutes, preferably 20 minutes, detecting the pH value of a material body after uniform mixing, and discharging through a 200-mesh screen after the pH value is qualified.
Example 4:
raw materials and proportion:
the component A comprises:
and B component:
the component C at least comprises the following raw materials in percentage by weight:
the preparation method comprises the following steps:
(1) weighing the component A materials in advance, soaking the components in an emulsifying preparation pot in advance until the components are completely wetted, sequentially adding the component A materials, homogenizing and dispersing the components uniformly, starting stirring and heating, heating to 80-85 ℃, and then preserving the temperature and stirring for 10 minutes;
(2) weighing the component B in advance, putting the component B into an oil pan, stirring and heating the component B, pumping the component B into an emulsifying preparation pan after heating the component B to 70-80 ℃, preserving the heat of the component B at 70-75 ℃, and homogenizing the component B for 10 minutes at a high speed;
(3) cooling to 45 ℃, wetting the chitin with pentanediol in advance until the chitin is uniform for later use, adding the component C, slowly homogenizing for 3-6 minutes, preferably slowly homogenizing for 5 minutes, stirring (40 revolutions per minute) for 15-25 minutes, preferably 20 minutes, detecting the pH value of a material body after uniform mixing, and discharging through a 200-mesh screen after the pH value is qualified.
The source of the raw materials for the four examples is shown in the following table:
in the four examples, example 1 was used as a control group without adding the chitin composition, and examples 2-4 were used as experimental groups with different amounts of chitin compositions with synergistic polypeptides.
Stability experiment of acne-removing repairing efficacy composition skin-care preparation
High and low temperature accelerated tests (30 days, 60 days and 90 days at-15 ℃, 45 ℃ and cold and hot cycles, respectively) were performed on examples 1 to 4, and the test results are shown in the following table:
the results show that: the external skin care preparation has excellent stability performance under the condition higher than the national standard, and can meet the requirement of marketing.
Efficacy experiment of acne-removing repairing efficacy composition skin-care preparation
Skin percutaneous water loss TEWL test
The test purpose is as follows: the skin barrier repairing efficacy of cosmetics was evaluated by detecting changes in skin transdermal water loss.
Testing the population: 20 healthy volunteers aged 18-50 years were recruited, with unlimited character.
Testing an instrument: vapometer percutaneous water loss measuring instrument (Delfin, Finland).
D-square adhesive tape (CUDerm Corporation, USA)
And (3) testing environment: the temperature is 22 +/-2 ℃; the composition has a humidity of 50% RH + -5% RH
The test method comprises the following steps: balancing the volunteer in a constant temperature and humidity environment for 30min, tearing the skin on the inner side of the left arm of the volunteer by an adhesive tape by an experimenter to cause an acute skin injury model (barrier injury model), respectively coating a placebo or a sample containing active substances on a selected area, wherein the coating amount is 2-4 mg/cm2. The TEWL values of the skin percutaneous water loss were measured before tear TO, immediately after tear, 30min after tear, 1h after tear, 2h after tear and 4h after tear. Statistical analysis is carried out by using SAS 9.4, the difference of skin before and after use is analyzed by using an analysis of variance method of a generalized linear model, and the test level alpha is 0.05. Since the test product has 4 types, the test part is carried out on the arm, and the influence on the test result is little for the crowd with pox or not.
And (3) testing results:
p < 0.05 with statistical differences.
**: p is less than 0.01, and the statistical difference is extremely remarkable.
(Note: the substrate is example 1, and chitin in the active matter with the acne-removing repair effect of the invention is not added on the basis of the formula)
The percutaneous water loss test of the skin with damaged barrier shows that (the lower the TEWL value is, the better the repair effect is), the repair effect of the embodiment 1 and the market competitive products is equivalent, and the repair effect of the embodiment 3 and the embodiment 4 is obviously better than that of the embodiment 1 and the market competitive products;
second, testing the oil content of skin
The test purpose is as follows: the oil control effect of the cosmetic is evaluated by detecting the change of the skin oil quantity.
Testing the population: 80 facial acne vulgaris volunteers aged 18-50 years were recruited, with unlimited character.
Testing an instrument: sebumeter of sebume skin (Delfin corporation, finland).
And (3) testing environment: the temperature is 22 +/-2 ℃; the composition has a humidity of 50% RH + -5% RH
The test method comprises the following steps: volunteers were randomized double-blindly into 4 groups of 20 individuals each, using 4 samples each. Balancing volunteers in a constant temperature and humidity environment for 30min, dividing a test area of 2cm by 2cm in the middle of the forehead of the volunteer by an experimenter, and coating a placebo or a sample containing active substances on the test area with the coating amount of 2-4 mg/cm2. The amount of oil in the skin was measured before use TO, with 3 days T1, with 7 days T2 and with 14 days T3. Statistical analysis is carried out by using SAS 9.4, the difference of skin before and after use is analyzed by using an analysis of variance method of a generalized linear model, and the test level alpha is 0.05.
And (3) testing results:
comparison P < 0.05 with example 1, with statistical differences.
Comparison P < 0.01 with example 1, with very significant statistical differences.
(Note: the substrate is example 1, and chitin in the active matter with the acne-removing repair effect of the invention is not added on the basis of the formula)
The oil control effect of the oil control agent in the invention in the examples 3 and 4 is obviously better than that of the substrate and the commercially known acne-removing product by testing the oil content of the skin (the lower value represents the less oil content and the better oil control function).
Test results show that the acne-removing repair composition and the skin care preparation can obviously reduce percutaneous water loss of skin, have lasting moisturizing capability, recover the health state of skin with damaged barrier, have obviously better repairing and oil controlling capabilities of the damaged barrier than those of products sold in the market, and have good application prospects. The product is mainly used for removing acne, is not used for repairing skin, but has the same advantages as skin repairing and needs to be adjusted.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. The composition with the acne-removing and repairing effects is characterized by comprising the following raw materials in percentage by weight:
0.5-3.0 wt% of acne-removing efficacy composition;
0.5-1.0 wt% of linseed extract;
0.02-0.5 wt% of chitin.
2. The composition with acne treatment and repair effects according to claim 1, wherein the composition with acne treatment effects is any one or a combination of several of salvia extract, magnolia bark extract, pomegranate peel extract, scutellaria root extract and white willow bark extract.
3. The composition with acne treatment and repair efficacies as claimed in claim 2, wherein the composition with acne treatment efficacies simultaneously contains salvia miltiorrhiza extract, magnolia bark extract and white willow bark extract.
4. The composition with the acne removing and repairing functions according to claim 1, wherein the chitin is small-molecule chitin with the molecular weight of less than 2 ten thousand daltons.
5. The composition skin care preparation with the acne removing and repairing effects is characterized by comprising a component A, a component B and a component C;
wherein, the component A at least comprises the following raw materials in percentage by weight:
the component B at least comprises the following raw materials in percentage by weight:
the component C at least comprises the following raw materials in percentage by weight:
6. the skin care preparation of the composition with the acne-removing and repairing effects as claimed in claim 5, wherein the composition with the acne-removing effects is any one or a combination of more of a red sage root extract, a magnolia bark extract, a pomegranate peel extract, a scutellaria root extract and a white willow bark extract.
7. The composition skin care preparation with the acne-removing and repairing efficacy according to claim 5,
raw materials and proportion:
the component A comprises:
and B component:
the component C at least comprises the following raw materials in percentage by weight:
8. the composition skin care preparation with the acne-removing and repairing effects according to claim 5, which is prepared from the following raw materials in parts by weight:
the component A comprises:
and B component:
the component C at least comprises the following raw materials in percentage by weight:
9. the composition skin care preparation with the acne-removing and repairing efficacy according to claim 5,
raw materials and proportion:
the component A comprises:
and B component:
the component C at least comprises the following raw materials in percentage by weight:
10. a method for preparing the acne-removing repair composition skin care preparation of any one of claims 5 to 9, which is characterized by comprising the following steps:
(1) weighing the component A materials in advance, soaking the components in an emulsifying preparation pot in advance until the components are completely wetted, sequentially adding the component A materials, homogenizing and dispersing the components uniformly, starting stirring and heating, heating to 80-85 ℃, and then preserving the temperature and stirring for 8-12 minutes for later use;
(2) weighing the component B in advance, putting the component B into an oil pan, starting stirring and heating, pumping the mixture into an emulsifying preparation pan after heating to 60-70 ℃, preserving the heat at 70-75 ℃, homogenizing at high speed for 8-15 minutes, and then starting cooling;
(3) cooling to 45 ℃, wetting the chitin to be uniform by using pentanediol in advance for later use, adding the component C material, homogenizing at a low speed for 5 minutes, stirring for 20 minutes, detecting the pH value of the material body after uniform mixing, and discharging through a 200-mesh screen after the pH value is qualified.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910700908.6A CN112294715A (en) | 2019-07-31 | 2019-07-31 | Composition with acne removing and repairing effects, skin care preparation and preparation method of skin care preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910700908.6A CN112294715A (en) | 2019-07-31 | 2019-07-31 | Composition with acne removing and repairing effects, skin care preparation and preparation method of skin care preparation |
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| CN112294715A true CN112294715A (en) | 2021-02-02 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115227606A (en) * | 2022-07-25 | 2022-10-25 | 维怡美生物科技(广州)有限公司 | Acne-removing composition, application thereof and acne-removing cream and water containing composition |
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