CN108338947A - A kind of skin care compositions with acne-removing, skin care formulation and preparation method thereof - Google Patents
A kind of skin care compositions with acne-removing, skin care formulation and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
Abstract
The present invention relates to a kind of skin care compositions with acne-removing, it includes mainly xanthans, butanediol, glycerine, allantoin, EDETATE SODIUM, plant Shu Min agent, Gotu Kola P.E, methoxysalicylic acid potassium, polyquaternium 73, sebum secretion inhibitor, plant presses down acne element, theaflavin, theanine, 1, 2 pentanediols, benzophenone 4, triethanolamine, essence, 40 rilanit specials of PEG and water, the present invention also provides a kind of methods preparing the skin care formulation with acne-removing using above-mentioned skin care compositions, and the skin care formulation made from above-mentioned preparation method.Skin care compositions scientific formulation of the invention is rigorous, effect definitely has no toxic side effect, and has effects that anti-acne, oil-control, bactericidal antiphlogistic, pore refining, repairs pockmark.
Description
Technical field
The skin care compositions that the present invention relates to a kind of with acne-removing, skin care formulation and preparation method thereof, belong to skin care
Product research and development technology field.
Background technology
The generation of acne mainly blocks with hypersteatosis, pilosebaceous duct, bacterium infection and inflammatory reaction etc.
Factor is closely related.Adolesce androgen especially testosterone in descendant's body level it is rapid increase, promote sebaceous glands development
And generate a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage, dyssebacia to form cutin simultaneously
Bolt, that is, micro mist thorn.Multiple-microorganism especially propionibacterium acnes mass propagation in hair follicle, the lipase that propionibacterium acnes generate
It decomposes sebum and generates free fatty, while chemotactic inflammatory cell and medium, finally induce and aggravate inflammatory reaction.
Invention content
It is an object of the present invention to overcome the shortcomings of the prior art and provide a kind of skin care groups with acne-removing
Close object, skin care formulation and preparation method thereof.
The first purpose of the invention is to provide a kind of skin care compositions with acne-removing, pass through technology below
Scheme is realized：
A kind of skin care compositions with acne-removing, which is characterized in that as follows including component and weight percentage：It is yellow
Virgin rubber, 0.18-0.22%；Butanediol, 2.8-3.2%；Glycerine, 2.8-3.2%；Allantoin, 0.09-0.11%；EDETATE SODIUM,
0.04-0.06%；Plant Shu Min agent, 0.9-1.1%；Gotu Kola P.E, 0.28-0.32%；Methoxysalicylic acid potassium, 0.4-
0.6%；Polyquaternium -73,0.9-1.1%；Sebum secretion inhibitor, 5.5-6.5%；Plant presses down acne element, 2.8-3.2%；Tea
Flavine, 0.4-0.6%；Theanine, 0.75-0.85%；1,2- pentanediol, 0.9-1.1%；UVNUL MS-40,0.28-0.32%；
Triethanolamine, 0.11-0.15%；Essence, 0.04-0.06%；Cremophor RH40,0.13-0.17%；Surplus is water.
As being further improved for the skin care compositions, the skin care compositions include component and weight percentage such as
Under：Xanthans, 0.2%；Butanediol, 3%；Glycerine, 3%；Allantoin, 0.1%；EDETATE SODIUM, 0.05%；Plant Shu Min agent,
1%；Gotu Kola P.E, 0.3%；Methoxysalicylic acid potassium, 0.5%；Polyquaternium -73,1%；Sebum secretion inhibitor,
6%；Plant suppression acne element, 3%；Theaflavin, 0.5%；Theanine, 0.8%；1,2- pentanediol, 1%；UVNUL MS-40,0.3%；Three
Ethanol amine, 0.13%；Essence, 0.05%；Cremophor RH40,0.15%；Surplus is water.
As being further improved for the skin care compositions, the plant Shu Min agent includes water, butanediol, radix sophorae extraction
Object, swollen fruit Radix root extract and Baical Skullcap root P.E.
As being further improved for the skin care compositions, water, butanediol, radix sophorae extraction in the plant Shu Min agent
The weight proportion of object, swollen fruit Radix root extract and Baical Skullcap root P.E is 55:35:3:3:4.
As being further improved for the skin care compositions, the sebum secretion inhibitor includes water, two sweet ammonia of nonanedioyl
Sour potassium, DMDM hydantoin and iodine propilolic alcohol butyl mephenesin Carbamate.
As being further improved for the skin care compositions, water, two sweet ammonia of nonanedioyl in the sebum secretion inhibitor
The weight proportion of sour potassium, DMDM hydantoin and iodine propilolic alcohol butyl mephenesin Carbamate is 44.5:50:5:0.5.
As being further improved for the skin care compositions, the plant suppression acne element includes water, butanediol, fructus hippophae extraction
Object, honeysuckle flower extract, kuh-seng root extract, hamamelis leaf extract, ethylene glycol, iodine propilolic alcohol butyl mephenesin Carbamate and
Methylisothiazolinone.
Second object of the present invention is to provide a kind of preparation method of the skin care compositions with acne-removing, passes through
Technical solution below is realized：
A kind of preparation method of the skin care formulation with acne-removing, it is characterised in that include the following steps：
(1) above-mentioned skin care compositions is used, each component in the skin care compositions is divided into A phase, B phase, C phase and D phases,
Wherein A phases include xanthans, butanediol, glycerol and water, and B phases are carried including allantoin, EDETATE SODIUM, plant Shu Min agent, centella
Take object, methoxysalicylic acid potassium, polyquaternium -73, sebum secretion inhibitor, plant suppression acne element, theaflavin, theanine and 1,2-
Pentanediol, C phases include UVNUL MS-40 and triethanolamine, and D phases include essence and Cremophor RH40；
(2) each component in B phases is uniformly mixed, mixture B is made；
(3) each component in C phases is uniformly mixed, mixture C is made；
(4) each component in D phases is uniformly mixed, mixture D is made；
(5) xanthans in A phases is first added to mixing in butanediol, is heated to 80-85 DEG C, then with its in B phases
Remaining component is mixed and stirred for uniformly, mixture A being made；
(6) and then by mixture A 50 DEG C or so are cooled to, sequentially add mixture B, mixture C, mixture D, stirring makes
It is uniformly mixed.
Third object of the present invention is to provide a kind of skin care formulations with acne-removing, pass through technical side below
Case is realized：
A kind of skin care formulation with acne-removing, it is characterised in that：The skin care formulation is by above-mentioned preparation method system
.
As being further improved for the skin care formulation, the skin care formulation is essence.
The present invention can reach following technique effect：
Skin care compositions scientific formulation of the invention is rigorous, effect definitely has no toxic side effect, and has anti-acne, oil-control, sterilization
Anti-inflammatory, repairs the effect of pockmark at pore refining.The prescription of skin care compositions is according to as follows：(1), Gotu Kola P.E has and repaiies
The effect of multiple skin, anti-acne trace；(2), methoxysalicylic acid potassium have effects that anti-acne, cutin of dispelling；(3), by water, nonanedioyl two
The sebum secretion inhibitor of glycine potassium, DMDM hydantoin and iodine propilolic alcohol butyl mephenesin Carbamate composition has anti-acne, oil-control
The effect of；(4), it is carried by water, butanediol, seabuckthorn fruit extract, honeysuckle flower extract, kuh-seng root extract, hamamelidis folium
Take the plant suppression acne element of object, ethylene glycol, iodine propilolic alcohol butyl mephenesin Carbamate and methylisothiazolinone composition that there is anti-acne, resist
The effect of bacterium, pore refining；(5) theaflavin has effects that anti-oxidant, antibacterial, anti-inflammatory, (6), theanine have elimination cell
The effect of tense situation, Cucumber Extract.
Specific implementation mode
The present invention is further explained in the light of specific embodiments.
Embodiment 1-4：The preparation of skin care formulation
Each component and corresponding mass percentage proportioning ginseng are shown in Table 1：
Table 1：
The preparation method of skin care formulation with acne-removing, includes the following steps：
(1) it presses shown in table 1, each component is divided into A phase, B phase, C phase and D phases；
(2) each component in B phases is uniformly mixed, mixture B is made；
(2.1) the plant Shu Min agent in B phases is by water, butanediol, kuh-seng root extract, swollen fruit Radix root extract and radix scutellariae
Extract presses 55:35:3:3:4 weight proportion composition；
(2.2) the sebum secretion inhibitor in B phases is by water, nonanedioyl Diglycocol potassium, DMDM hydantoin and iodine propine
Alcohol butyl mephenesin Carbamate 44.5:50:5:0.5 weight proportion composition；
(2.3) plant presses down acne element by water, butanediol, seabuckthorn fruit extract, honeysuckle flower extract, kuh-seng root extract, north
U.S. dollar thread leaf of plum extract, ethylene glycol, iodine propilolic alcohol butyl mephenesin Carbamate and methylisothiazolinone composition, plant press down acne element from
Shanghai Jia Ye companies buy.
(3) each component in C phases is uniformly mixed, mixture C is made；
(4) each component in D phases is uniformly mixed, mixture D is made；
(5) xanthans in A phases is added to mixing in butanediol, is heated to 80-85 DEG C, then with remaining in B phases
Component is mixed and stirred for uniformly, obtaining mixture A；
(6) and then by mixture A 50 DEG C or so are cooled to, sequentially add mixture B, mixture C, mixture D, stirring makes
It is uniformly mixed.
Use skin care formulation made from above-mentioned preparation method for essence.
Gotu Kola P.E, kuh-seng root extract, swollen fruit Radix root extract, the radix scutellariae used in above-mentioned preparation process carry
It is commercially available or normal to take object, seabuckthorn fruit extract, honeysuckle flower extract, kuh-seng root extract, hamamelis leaf extract etc.
Extracting method extraction is advised, remaining raw material is commercially available, and the present invention is not described further.
In the present invention, sense organ apparent according to finished product effect obtained by embodiment 3 is good, pH value and consistency are moderate, quality
Stablize, is best mode for carrying out the invention.
Embodiment 6：Efficacy test：
One, Sensory testing results：After the essence for just having tried out above-described embodiment preparation, trier's skin oil and fat secretory volume
It reduces, face skin bellding light has different degrees of decrease.Skin water profit is apparent.Salubrious sense becomes apparent from, and trier feels product
Comfortably, fat secretion amount is reduced.After persistently using 1 month, the skin oil optical phenomenon of trier, which improves, to be increased.
Thus illustrate, essence of the invention can play the role of skin antibacterial, anti-acne, moisturizing, Sage Extract, effect
It is satisfactory.
Two, skin test：
Test method：The acne flesh volunteer (20~30 years old) of selection 30 participates in free efficacy test.The skin care of experiment
Product are using the essence prepared by embodiment 1-5, as required after face has acne regional sustained to use 4 weeks, investigate implement respectively
The essence prepared in example is to the improvement in terms of face skin fat content, moisture of skin water content, skin acne number situation of change
Situation is simultaneously periodically counted.
It is required that conventionally using (it is 1 yuan of coin-size to smear general dosage every time), once in the morning and once at night.The test phase
Between, deactivate other similar skin care item.
1, volunteer's face skin is carried out using skin moisture content tester CM825 (German CK electronics corporations produce)
Water analysis, change of moisture content value before the opposite detection of detection test zone skin, test result is as shown in table 2, and changing value is got over
Greatly, illustrate that moisturizing effect is better：
Table 2：
| 7 days | 14 days | 30 days | |
| Moisture changing value | 5.3% | 8.1% | 12.7% |
In terms of experimental data, during experiment, skin moisture content is in increase trend, illustrates the essence energy using the present invention
Effectively supplement moisture of skin.
2, skin oil and fat detection is carried out using skin oil and fat tester SM815 (German CK electronics corporations produce), detection is surveyed
The preceding fat secretion changing value of the opposite detection of area skin is tried, test result is as shown in table 3：
Table 3：
| 7 days | 14 days | 30 days | |
| Fat secretion changing value | - 2.1% | - 3.0% | - 4.3% |
In terms of experimental data, during experiment, skin oil and fat secretory volume is substantially reduced, and illustrates the essence using the present invention
Skin oil and fat content can effectively be reduced.
3, skin acne number situation of change：
Count subject's acne number：Acne is counted and is judged, for judging the direct anti-acne effect of the present invention (such as 4 institute of table
Show).
Table 4：
| 7 days | 14 days | 30 days | |
| Skin acne number changing value | - 31.7% | - 49.2% | - 74.1% |
It counts and judges by regular acne, the acne of tested volunteer can be substantially reduced using the essence of the present invention
Number, illustrates that the present invention can be with limited anti-acne.
Three, human body irritation and patch experiment：
Human body irritant experiment uses non-stimulated experiment (RBC Test System)；Human body patch is tested according to 2015 editions
《Cosmetics safety technical specification》Requirement carry out.
Human body irritant experiment result：(the addition concentration of 800ppm) at low concentrations, hemolysis rate of the invention is very low, should
Sample is smaller to cell membrane damage, it was demonstrated that the present invention is under RBC Test System test systems without intense irritation.Highly concentrated
Under degree, under the full test concentration of the test system (the addition concentration of 6400ppm), hemolysis rate of the invention is about
4.03%.Prove that inventive samples are nonirritant under RBC Test System test systems.
Three, human body patch experimental result (as shown in table 5- tables 7)：
Table 5：Remove 0.5 hour observation result of spot examination device
Table 6：Remove 24 hours observation results of spot examination device
Table 7：Remove 48 hours observation results of spot examination device
The experimental results showed that：Patch test results in this time testing, according to 2015 editions《Cosmetics safety technical specification》's
It is required that judging that the skin care formulation of the present invention has no adverse reaction to human skin.
Embodiment described above is only to absolutely prove preferred embodiment that is of the invention and being lifted, protection model of the invention
It encloses without being limited thereto.Those skilled in the art on the basis of the present invention made by equivalent substitute or transformation, in the present invention
Protection domain within.Protection scope of the present invention is subject to claims.
Claims (10)
1. a kind of skin care compositions with acne-removing, which is characterized in that as follows including component and weight percentage：Xanthan
Glue, 0.18-0.22%；Butanediol, 2.8-3.2%；Glycerine, 2.8-3.2%；Allantoin, 0.09-0.11%；EDETATE SODIUM,
0.04-0.06%；Plant Shu Min agent, 0.9-1.1%；Gotu Kola P.E, 0.28-0.32%；Methoxysalicylic acid potassium, 0.4-
0.6%；Polyquaternium -73,0.9-1.1%；Sebum secretion inhibitor, 5.5-6.5%；Plant presses down acne element, 2.8-3.2%；Tea
Flavine, 0.4-0.6%；Theanine, 0.75-0.85%；1,2- pentanediol, 0.9-1.1%；UVNUL MS-40,0.28-0.32%；
Triethanolamine, 0.11-0.15%；Essence, 0.04-0.06%；Cremophor RH40,0.13-0.17%；Surplus is water.
2. the skin care compositions with acne-removing as described in claim 1, it is characterised in that：The skin care compositions includes
Component and weight percentage are as follows：Xanthans, 0.2%；Butanediol, 3%；Glycerine, 3%；Allantoin, 0.1%；EDTA bis-
Sodium, 0.05%；Plant Shu Min agent, 1%；Gotu Kola P.E, 0.3%；Methoxysalicylic acid potassium, 0.5%；Polyquaternium -73,
1%；Sebum secretion inhibitor, 6%；Plant suppression acne element, 3%；Theaflavin, 0.5%；Theanine, 0.8%；1,2- pentanediol,
1%；UVNUL MS-40,0.3%；Triethanolamine, 0.13%；Essence, 0.05%；Cremophor RH40,0.15%；Surplus is
Water.
3. the skin care compositions with acne-removing as described in claim 1, it is characterised in that：The plant Shu Min agent includes
Water, butanediol, kuh-seng root extract, swollen fruit Radix root extract and Baical Skullcap root P.E.
4. the skin care compositions with acne-removing as claimed in claim 3, it is characterised in that：In the plant Shu Min agent
Water, butanediol, kuh-seng root extract, swollen fruit Radix root extract and Baical Skullcap root P.E weight proportion be 55: 35: 3: 3: 4.
5. the skin care compositions with acne-removing as described in claim 1, it is characterised in that：The sebum secretion inhibitor
Including water, nonanedioyl Diglycocol potassium, DMDM hydantoin and iodine propilolic alcohol butyl mephenesin Carbamate.
6. the skin care compositions with acne-removing as claimed in claim 5, it is characterised in that：The sebum secretion inhibitor
In water, nonanedioyl Diglycocol potassium, DMDM hydantoin and iodine propilolic alcohol butyl mephenesin Carbamate weight proportion be 44.5: 50
∶5∶0.5。
7. the skin care compositions with acne-removing as described in claim 1, it is characterised in that：The plant presses down acne element
Water, butanediol, seabuckthorn fruit extract, honeysuckle flower extract, kuh-seng root extract, hamamelis leaf extract, ethylene glycol, iodine
Propilolic alcohol butyl mephenesin Carbamate and methylisothiazolinone.
8. a kind of preparation method of the skin care formulation with acne-removing, it is characterised in that include the following steps：
(1) skin care compositions for using claim 1, is divided into A phase, B phase, C phase and D by each component in the skin care compositions
Phase, wherein A phases include xanthans, butanediol, glycerol and water, and B phases include allantoin, EDETATE SODIUM, plant Shu Min agent, centella
Extract, methoxysalicylic acid potassium, polyquaternium -73, sebum secretion inhibitor, plant suppression acne element, theaflavin, theanine and 1,
2- pentanediols, C phases include UVNUL MS-40 and triethanolamine, and D phases include essence and Cremophor RH40；
(2) each component in B phases is uniformly mixed, mixture B is made；
(3) each component in C phases is uniformly mixed, mixture C is made；
(4) each component in D phases is uniformly mixed, mixture D is made；
(5) xanthans in A phases is first added to mixing in butanediol, is heated to 80-85 DEG C, then with remaining group in B phases
Divide and is mixed and stirred for uniformly, mixture A being made；
(6) and then by mixture A 50 DEG C or so are cooled to, sequentially add mixture B, mixture C, mixture D, stirring makes mixing
Uniformly.
9. a kind of skin care formulation with acne-removing, it is characterised in that：The skin care formulation by claim 7 or 8 preparation
Method is made.
10. the skin care formulation with acne-removing as claimed in claim 9, it is characterised in that：The skin care formulation is essence
Element.
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| CN110664700A (en) * | 2019-11-25 | 2020-01-10 | 广州赛莱拉生物基因工程有限公司 | Composition and application thereof in preparation of product for preventing and treating acne |
| CN110772465A (en) * | 2019-12-17 | 2020-02-11 | 厦门泽本健康管理有限公司 | Acne mark removing composition |
| CN110897959A (en) * | 2019-12-19 | 2020-03-24 | 天津达仁堂京万红药业有限公司 | Plant extract soothing essence and preparation method thereof |
| CN112137926A (en) * | 2020-09-08 | 2020-12-29 | 四川万物本草健康科技有限公司 | Product composition containing rhizoma atractylodis and application of product composition in skin care products |
| CN112294715A (en) * | 2019-07-31 | 2021-02-02 | 上海金皮宝制药有限公司 | Composition with acne removing and repairing effects, skin care preparation and preparation method of skin care preparation |
| CN112315883A (en) * | 2020-11-24 | 2021-02-05 | 哈尔滨敷尔佳科技发展有限公司 | Skin care composition for controlling oil and removing acne and preparation and application thereof |
| CN112438941A (en) * | 2020-12-31 | 2021-03-05 | 杭州菲丝凯化妆品有限公司 | Allergy-relieving repair composition and skin care product containing same |
| CN113456534A (en) * | 2021-07-29 | 2021-10-01 | 国药医养化妆品研发(杭州)有限公司 | Oil-control acne-removing mixture with multiple skin-care effects and preparation method thereof |
| CN113520933A (en) * | 2021-03-31 | 2021-10-22 | 雅威盛(北京)科技发展有限公司 | Plant extract for external application of oil-controlling acne-removing mask and oil-controlling acne-removing mask |
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Application publication date: 20180731 |