CN102670451A - Functional skin care product containing paris polyphylla extract for treating acnes and preparation method of functional skin care product - Google Patents

Functional skin care product containing paris polyphylla extract for treating acnes and preparation method of functional skin care product Download PDF

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CN102670451A
CN102670451A CN2012101711726A CN201210171172A CN102670451A CN 102670451 A CN102670451 A CN 102670451A CN 2012101711726 A CN2012101711726 A CN 2012101711726A CN 201210171172 A CN201210171172 A CN 201210171172A CN 102670451 A CN102670451 A CN 102670451A
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skin care
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extract
care product
rhizoma paridis
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何黎
郭振宇
孙东杰
刘海洋
高绍阳
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Abstract

The invention discloses a functional skin care product containing a paris polyphylla extract for treating acnes and a preparation method of the functional skin care product. The functional skin care product comprises the following raw materials in parts by weight: 50-70 parts of deionized water, 0.1 part of paris polyphylla extract, 0.5-1 part of prinsepia utilis royle oil, 1-5 parts of herba portulacae extract, 2-5 parts of glycerol, 3-5 parts of butanediol, 2-5 parts of 1,2-pentanediol, 2-8 parts of polydimethylsiloxane, 1-4 parts of nicotinamide, 1-2 parts of hydroxyethyl acrylate/sodium dimethyl acrylamide taurine copolymer, 0.1-0.5 part of acrylates (acrylic esters) C10-30 alkanol acrylate cross-linked polymer and 1-5 parts of silandiol salicylate. The functional skin care product contains the paris polyphylla extract, has the effect of resisting propionibacterium acnes, staphylococcus epidermidis and staphylococcus aureus, and is also good in safety without side and toxic effects.

Description

The effect property skin care item and the method for preparing that contain the treatment acne of Rhizoma Paridis extract
Technical field
The present invention relates to technical field of skin care, effect property skin care item of particularly a kind of auxiliary treatment acne that contains Rhizoma Paridis extract and preparation method thereof.
Background technology
The skin care item exploitation that with the plant is main component in recent years receives publicity day by day, is whitening, is preserving moisture and aspect such as Shu Min has been widely used, and obtaining gratifying effect.Effect property skin care item are the specific type skin care item that dermatosis had the auxiliary treatment effect, and exploitation is main with plant component, and the effect property skin care item of the multiple common dermatosis of ability auxiliary treatment have become this area research inexorable trend and focus.
One of pathogenetic important step of acne is: corynebacterium acnes infects; At present; Contain following several types of materials to the main external used medicine of this link: antibiotic, retinoic acid, benzoyl peroxide etc.; Though can reach the purpose of effective inhibition corynebacterium acnes, there are problems such as the big and patient's compliance difference of drug resistance, zest, had a strong impact on the remedy of acne effect.Research both at home and abroad confirms that the application of effect property skin care item can improve the acne skin lesion, but because effect property skin care item forbid to add compositions such as antibiotic, it is limited to make that effect property skin care item are used for the acne auxiliary treatment.Therefore, research and development have antiinflammatory, antibacterial action, its effect and the suitable plant extract of anti-acne propanoic acid corynebacterium antibiotic, and add in the preparation of effect property skin care item, the auxiliary treatment that is used for acne has application prospect.
Rhizoma Paridis (Yunnan Manyleaf Paris Rhizome), another name Rhizoma Paridis, Rhizoma Paridis, Typhonium divaricatum (L.) Decne.For liliaceous plant Rhizoma Paridis rhizome, mainly originate in Yunnan, it has heat-clearing and toxic substances removing, effects such as reducing swelling and alleviating pain.Being mainly used in diseases such as furuncle, carbuncle, laryngopharynx swelling and pain, venom, also is one of main composition medicine of famous patent medicine YUNNAN BAIYAO, jidesheng sheyao tablets.The alcohol extract of experimentation proof Rhizoma Paridis includes the steroid saponin of multiple biologically active, as diosgenin (diosgenin) and pennogenin (pennogenin) two, three, the tetrose glycoside, make it have effects such as infection, hemostasis, antiinflammatory.Clinically, the Rhizoma Paridis tincture treatment furuncle, carbuncle, the folliculitis that prepare voluntarily of more domestic hospitals also obtained satisfactory effect.We through experiment confirm the Rhizoma Paridis extract have the effect of anti-acne propionibacterium, staphylococcus epidermidis and staphylococcus aureus, therefore, design and research and development contain the Rhizoma Paridis extract can auxiliary treatment the effect property skin care item of acne, be the purpose of this research.
Summary of the invention
The purpose of this invention is to provide a kind of effect property skin care item that Rhizoma Paridis is put forward the auxiliary treatment acne of thing that contain, good, the no toxicity of safety when making effect property skin-protection product have effect property.
The present invention passes through experiment in vitro; Clear and definite Rhizoma Paridis extract has the effect of anti-acne propionibacterium, staphylococcus epidermidis and staphylococcus aureus; And confirm that the suitable concentration that this extract adds in the skin care item is 0.1%, good, the no toxicity of safety when making effect property skin-protection product have effect property.
The Rhizoma Paridis that contains of the present invention is put forward the effect property raw material of skin care articles parts by weight of component of the auxiliary treatment acne of thing and is:
Deionized water 50-70 part, 0.1 part of Rhizoma Paridis extract, Princepia utilis oil 0.5-1 part, Herba portulacae extract 1-5 part, glycerol 2-5 part, butanediol 3-5 part, 1,2 pentanediol 2-5 part, polydimethylsiloxane 2-8 part, nicotiamide 1-4 part, 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers 1-2 part, acrylic acid (ester) type C10-30 alkylol acrylamide acid esters cross linked polymer 0.1-0.5 part, silandiol salicylate 1-5 part.
The method for preparing above-mentioned effect property skin care item is carried out according to the following steps:
1) with the A component: deionized water, acrylic acid (ester) type C10-30 alkylol acrylamide acid esters cross linked polymer 0.1-0.5 part, glycerol, butanediol add in the kettle, and are heated to 75-80 ℃;
2) with the B component: Princepia utilis oil, polydimethylsiloxane, 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers add in the oil cauldron, and are heated to 75-80 ℃;
3) A is organized solution and in the emulsifying pot, mix with B group solution, and emulsifying 10min;
4) above-mentioned emulsion is cooled to 40 ℃;
5) add the C phase component: Herba portulacae extract, 1,2-pentanediol, nicotiamide, Rhizoma Paridis carry that thing, silandiol salicylate stir discharging behind the 10min, leave standstill, fill, packing.
Rhizoma Paridis extract anti-acne propionibacterium, staphylococcus epidermidis and staphylococcus aureus effect Journal of Sex Research:
Plant origin: Rhizoma Paridis (Yunnan Manyleaf Paris Rhizome), another name: Rhizoma Paridis, Typhonium divaricatum (L.) Decne.Be liliaceous plant Rhizoma Paridis rhizome.
Carry out external bacteriostatic experiment with the ethanol extraction Rhizoma Paridis; Reference substance is that water and methanol extraction Rhizoma Paridis method extract obtained and that adopt the micropore dilution method to survey Maxwell turbidity and plate dilution method observation colony growth is confirmed MIC; Searching has the extraction product and the activity of bacteriostatic activity the most by force in the product of Different Extraction Method, is convenient to confirm to add the optium concentration in the skin care item.Compile respectively according to Different Extraction Method (water, methanol and ethanol) sample and to be HPP-1, HPP-2 and HPP-3.
Buy propionibacterium acnes (NCTC737; Huankai Microbes Tech Co., Ltd., Guangdong), staphylococcus aureus (CMCC26003; Huankai Microbes Tech Co., Ltd., Guangdong) and staphylococcus epidermidis type strain (CMCC26069; Huankai Microbes Tech Co., Ltd., Guangdong), from patient's skin lesion separation and Culture propionibacterium acnes clinical strain (KM34,67) as object of observation; If matched group and experimental group, positive controls are respectively erythromycin (INALCO SPA Milano ITALY), clindamycin (BIODEE), they all have the effect of anti-acne propionibacterium; Penicillin, vancomycin (Huankai Microbes Tech Co., Ltd., Guangdong); All have anti-staphylococcus aureus, staphylococcus epidermidis effect; Negative control only adds inoculum and does not add the Rhizoma Paridis extract; Experimental group adds the variable concentrations Rhizoma Paridis extract, gets experimental group and matched group observation respectively at anaerobism cultivation 48h (propionibacterium acnes) and aerobic cultivation 24h.
Experimental result:
1, to the inhibitory action of propionibacterium acnes:
1) to the inhibitory action (MIC) of NCTC737:
(1) liquid micropore dilution method:
3 kinds of extracts of Rhizoma Paridis have tangible fungistatic effect, wherein HPP-1:0.65mg/ml; HPP-2:0.65mg/ml; HPP-3:0.04mg/ml, erythromycin MIC:0.0125ug/ml, clindamycin MIC:0.0250ug/ml, blank has bacteria growing.HPP-3 (Rhizoma Paridis second ethanol extract) fungistatic effect is the strongest.
Table 1A: micropore dilution method OD600nm value of reading before anaerobism is cultivated
Figure BDA00001699331900031
Table 1B: micropore dilution method OD600nm value of reading behind the anaerobism cultivation 48h
Figure BDA00001699331900032
Figure BDA00001699331900041
" overstriking " font is OD value of reading of MIC
2) plate dilution method:
Six kinds of extracts of Rhizoma Paridis have tangible fungistatic effect, wherein HPP-1:0.65mg/ml; HPP-2:0.65mg/ml; HPP-3:0.04mg/ml, erythromycin MIC:0.0125ug/ml, clindamycin MIC:0.0250ug/ml, blank has bacteria growing.HPP-3 (Rhizoma Paridis ethanol extraction) fungistatic effect is the strongest.
Table 2: BHI flat-plate bacterial colony growing state behind the anaerobism cultivation 48h
Figure BDA00001699331900042
"+" is that dull and stereotyped growth bacterium colony is greater than 5/culture plate; "-" is that dull and stereotyped growth bacterium colony is less than 5/flat board;
"--" is MIC value colony growth situation of living in.
(2) to KM34,67 inhibitory action (MIC)
Similar with result " (1) ", six kinds of extracts of Rhizoma Paridis have tangible fungistatic effect, wherein HPP-1:0.65mg/ml; HPP-2:0.65mg/ml; HPP-3:0.04mg/ml, erythromycin MIC:0.0125ug/ml, clindamycin MIC:0.0250ug/ml, blank has bacteria growing.HPP-3 (Rhizoma Paridis ethanol extraction) fungistatic effect is the strongest.
A, liquid micropore dilution method
A1, KM34 liquid micropore dilution method
OD600nm value of reading behind the table 3KM34 anaerobism cultivation 48h
Figure BDA00001699331900051
" overstriking " font is OD value of reading of MIC
A2, KM67 liquid micropore dilution method
OD600nm value of reading behind the table 4KM67 anaerobism cultivation 48h
Figure BDA00001699331900052
" overstriking " font is OD value of reading of MIC
B, BHI agar plate dilution method
B1, KM34BHI agar plate dilution method
Table 5: BHI flat-plate bacterial colony growing state behind the anaerobism cultivation 48h
Figure BDA00001699331900053
Figure BDA00001699331900061
--be OD value of reading of MIC
B2, KM67BHI agar plate dilution method: result and " b1 " are similar
2, to aureus with inhibition:
(1) micropore dilution method: HPP-1:0.33mg/ml; HPP-2:0.33mg/ml; HPP-3:0.02mg/ml, penicillin MIC:0.025ug/ml, vancomycin MIC:0.0125ug/ml.Blank has bacteria growing.HPP-3 (Rhizoma Paridis ethanol extraction) fungistatic effect is the strongest.
Table 6A: OD600nm value of reading before staphylococcus aureus is cultivated
Figure BDA00001699331900062
Table 6B: OD600nm value of reading behind the aerobic cultivation 24h
Figure BDA00001699331900063
Figure BDA00001699331900071
" overstriking " font is OD value of reading of MIC
(2) plate dilution method: HPP-1:0.33mg/ml; HPP-2:0.33mg/ml; HPP-3:0.02mg/ml, penicillin MIC:0.025ug/ml, vancomycin MIC:0.0125ug/ml.Blank has bacteria growing.HPP-3 (Rhizoma Paridis ethanol extraction) fungistatic effect is the strongest.
Table 7: MH flat-plate bacterial colony growing state behind the aerobic cultivation 24h
Figure BDA00001699331900072
--be OD value of reading of MIC
3, to the staphylococcic inhibitory action of epidermis: micropore dilution method and plate dilution method result are all similar with result " 2 ".
(1) micropore dilution method: HPP-1:1.3mg/ml; HPP-2:1.3mg/ml; HPP-3:0.08mg/ml, penicillin MIC:0.05ug/ml, vancomycin MIC:0.0250ug/ml.Blank has bacteria growing.HPP-3 (Rhizoma Paridis ethanol extraction) fungistatic effect is the strongest.
Table 8: OD600nm value of reading behind the aerobic cultivation of the staphylococcus epidermidis 24h
Figure BDA00001699331900081
" overstriking " font is OD value of reading of MIC
(2) agar plate dilution method: HPP-1:1.3mg/ml; HPP-2:1.3mg/ml; HPP-3:0.02mg/ml, penicillin MIC:0.05ug/ml, vancomycin MIC:0.0250ug/ml.Blank has bacteria growing.HPP-3 (Rhizoma Paridis ethanol extraction) fungistatic effect is the strongest.
Table 9: MH flat-plate bacterial colony growing state behind the aerobic cultivation 24h
Figure BDA00001699331900082
--be OD value of reading of MIC
Through external bacteriostatic experiment; Rhizoma Paridis water, methanol and ethanol extraction all have certain bacteriostasis to propionibacterium acnes, staphylococcus epidermidis and staphylococcus aureus; Wherein the fungistatic effect of HPP-3 (Rhizoma Paridis ethanol extraction) is better than water and methanolic extract, when 0.04mg/ml concentration, has the anti-acne propionibacterium effect that is equal to erythromycin (0.0125ug/ml) and clindamycin (0.0250ug/ml); The effect of the anti-staphylococcus aureus that under 0.02mg/ml concentration, is equal to penicillin (0.025ug/ml) and vancomycin (0.0125ug/ml); The effect that under 0.08mg/ml concentration, has the anti-staphylococcus epidermidis that is equal to penicillin (0.05ug/ml) and vancomycin (0.0250ug/ml).Therefore, select for use 0.1% Rhizoma Paridis ethanol extraction to add in the effect property skin care item preparation of auxiliary treatment acne.
Description of drawings
Below in conjunction with the accompanying drawing and the specific embodiment the present invention is done further detailed description.
Fig. 1 is the process flow diagram of the method for preparing of effect property skin care item of the present invention.
Fig. 2 Rhizoma Paridis extract extraction process schematic flow sheet.
Fig. 3 Herba portulacae extract extraction process schematic flow sheet.
The specific embodiment
Embodiment 1:
The Rhizoma Paridis of below using is carried thing for extracting by method shown in Figure 2, and Herba portulacae extract extracts by method shown in Figure 3.
Prescription is following table (unit is a weight portion)
Figure BDA00001699331900091
The method for preparing above-mentioned effect property skin care item is following:
1, A component (deionized water, acrylic acid (ester) type C10-30 alkylol acrylamide acid esters cross linked polymer, glycerol, butanediol) is added in the kettle, and be heated to 75-80 ℃;
2, B component (Princepia utilis oil, polydimethylsiloxane, 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers) is added in the oil cauldron, and be heated to 75-80 ℃;
3, A is organized solution and in the emulsifying pot, mix with B group solution, and emulsifying 10min;
4, above-mentioned emulsion is cooled to 40 ℃;
5, add that C phase component (Herba portulacae extract, 1,2-pentanediol, nicotiamide, Rhizoma Paridis are carried thing, silandiol salicylate) stirs discharging behind the 10min, leaves standstill, fill, packing.
Embodiment 2:
Prescription is following table (unit is a weight portion)
Figure BDA00001699331900101
The method of effect property skin care item for preparing above-mentioned prescription is identical with embodiment 1.
Embodiment 3:
Prescription is following table (unit is a weight portion)
Figure BDA00001699331900102
Figure BDA00001699331900111
The method of effect property skin care item for preparing above-mentioned prescription is identical with embodiment 1.

Claims (2)

1. effect property skin care item that contain the treatment acne of Rhizoma Paridis extract; It is characterized in that its parts by weight of raw materials component is: deionized water 50-70 part, Rhizoma Paridis are carried 0.1 part of thing, Princepia utilis oil 0.5-1 part, Herba portulacae extract 1-5 part, glycerol 2-5 part, butanediol 3-5 part, 1,2-pentanediol 2-5 part, polydimethylsiloxane 2-8 part, nicotiamide 1-4 part, 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers 1-2 part, acrylic acid (ester) type C10-30 alkylol acrylamide acid esters cross linked polymer 0.1-0.5 part, silandiol salicylate 1-5 part.
2. the method for preparing of the effect property skin care item of the described treatment acne that contains Rhizoma Paridis extract of claim 1 is characterized in that carrying out according to the following steps:
1) with the A component: deionized water, acrylic acid (ester) type C10-30 alkylol acrylamide acid esters cross linked polymer, glycerol, butanediol add in the kettle, and are heated to 75-80 ℃;
2) with the B component: Princepia utilis oil, polydimethylsiloxane, 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers add in the oil cauldron, and are heated to 75-80 ℃;
3) A is organized solution and in the emulsifying pot, mix with B group solution, and emulsifying 10min;
4) above-mentioned emulsion is cooled to 40 ℃;
5) add the C phase component: Herba portulacae extract, 1,2-pentanediol, nicotiamide, silandiol salicylate, Rhizoma Paridis extract stir discharging behind the 10min, leave standstill, fill, packing.
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104958227A (en) * 2015-07-28 2015-10-07 上海贝泰妮生物科技有限公司 Essence skin protection preparation with acne removing effect and preparation method thereof
CN105125431A (en) * 2015-07-28 2015-12-09 上海贝泰妮生物科技有限公司 Acne clearing composition having acne clearing efficacy, facial mask and facial mask preparation method
CN106344472A (en) * 2016-10-08 2017-01-25 广州丹奇日用化工厂有限公司 Pure traditional Chinese medicine acne-removal mask
CN107362092A (en) * 2017-08-22 2017-11-21 安徽省中日农业环保科技有限公司 A kind of anti-acne essence containing Chinese herbal medicine
CN107412107A (en) * 2017-08-30 2017-12-01 安徽省中日农业环保科技有限公司 A kind of anti-acne repair latex containing essential oil
CN110051626A (en) * 2018-01-18 2019-07-26 杜权 A kind of two-phase oil formulation and its application
CN112168912A (en) * 2020-09-30 2021-01-05 云南贝泰妮生物科技集团股份有限公司 Plant compound capable of inhibiting acne-related pathogenic bacteria and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030228379A1 (en) * 2002-05-28 2003-12-11 Wenyuan Shi Herbs and herbal combinations useful for the treatment of microbial infections
CN102406576A (en) * 2011-10-28 2012-04-11 何黎 Prinsepia utilis Royle oil-containing functional skin care product and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030228379A1 (en) * 2002-05-28 2003-12-11 Wenyuan Shi Herbs and herbal combinations useful for the treatment of microbial infections
CN102406576A (en) * 2011-10-28 2012-04-11 何黎 Prinsepia utilis Royle oil-containing functional skin care product and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
林逢春: "滇重楼抑菌效果研究", 《健康必读杂志》, no. 6, 30 June 2010 (2010-06-30) *
黄畋等: "48种中药对痤疮丙酸杆菌的抑菌作用", 《中华皮肤科杂志》, vol. 25, no. 5, 31 December 1992 (1992-12-31) *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104958227A (en) * 2015-07-28 2015-10-07 上海贝泰妮生物科技有限公司 Essence skin protection preparation with acne removing effect and preparation method thereof
CN105125431A (en) * 2015-07-28 2015-12-09 上海贝泰妮生物科技有限公司 Acne clearing composition having acne clearing efficacy, facial mask and facial mask preparation method
CN106344472A (en) * 2016-10-08 2017-01-25 广州丹奇日用化工厂有限公司 Pure traditional Chinese medicine acne-removal mask
CN107362092A (en) * 2017-08-22 2017-11-21 安徽省中日农业环保科技有限公司 A kind of anti-acne essence containing Chinese herbal medicine
CN107412107A (en) * 2017-08-30 2017-12-01 安徽省中日农业环保科技有限公司 A kind of anti-acne repair latex containing essential oil
CN110051626A (en) * 2018-01-18 2019-07-26 杜权 A kind of two-phase oil formulation and its application
CN110051626B (en) * 2018-01-18 2022-10-04 杜权 Two-phase oil preparation and application thereof
CN112168912A (en) * 2020-09-30 2021-01-05 云南贝泰妮生物科技集团股份有限公司 Plant compound capable of inhibiting acne-related pathogenic bacteria and application thereof

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Application publication date: 20120919