CN105287734A - Traditional Chinese medicinal paper with antibacterial effect and preparation method thereof - Google Patents
Traditional Chinese medicinal paper with antibacterial effect and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of papermaking, and particularly provides traditional Chinese medicinal paper with an antibacterial effect and a preparation method of the traditional Chinese medicinal paper, wherein traditional Chinese medicinal materials comprise the following components in parts by weight: 10-100 parts of ginkgo leaves, 10-100 parts of rhizoma chuanxiong leaves, 10-100 parts of angelica sinensis leaves, 10-100 parts of mangnolia officinalis leaves, 5-80 parts of folium mori, and 5-80 parts of edible araliae cordatae roots. The traditional Chinese medicinal materials are processed, and then subjected to conventional papermaking steps including batching and papermaking to prepare the traditional Chinese medicinal paper with the antibacterial effect. According to the traditional Chinese medicinal paper, the active ingredients of the traditional Chinese medicinal materials are completely dissolved in the paper, and the paper has the natural fragrance and has the effect of removing bacteria in the skin. According to the preparation method provided by the invention, the traditional Chinese medicinal mixed liquor is added in the pulping process of the common paper, and the preparation method is simple, low in cost, and suitable for industrial production.
Description
Technical field
The present invention relates to a kind of paper and preparation method thereof, more particularly, the present invention relates to a kind of Chinese medicine paper with antibacterial action and preparation method thereof, belong to pulp technology for making paper.
Background technology
Paper is life consumable goods the most universal in society life, can be roughly divided into toilet paper, paper handkerchief, moisture paper tissue papers, toilet paper etc. according to its function.Now commercially available paper, due to the easy breed bacteria of wet weather, not only makes paper storage life greatly reduce, and also easily makes skin carry disease germs infection in use simultaneously.Given this, the needs improveing to meet people's daily life to existing paper are needed.
Summary of the invention
The object of the invention is to solve the deficiencies in the prior art, provide a kind of Chinese crude drug paper with antibacterial action, this paper is toilet paper, moisture paper tissue papers and tissue.
The Chinese crude drug of this Chinese crude drug paper is made up of following raw material and weight ratio:
Folium Ginkgo 10-100 weight portion, Rhizoma Chuanxiong leaf 10-100 weight portion, Folium Angelicae Sinensis 10-100 weight portion, Leaf of Magnolia officinalis 10-100 weight portion, Folium Mori 5-80 weight portion, Aralia cordata Thunb root 5-80 weight portion.
Preferably, the weight ratio of described each Chinese crude drug is: Folium Ginkgo 20-80 weight portion, Rhizoma Chuanxiong leaf 20-80 weight portion, Folium Angelicae Sinensis 20-80 weight portion, Leaf of Magnolia officinalis 20-80 weight portion, Folium Mori 10-70 weight portion, Aralia cordata Thunb root 10-70 weight portion.
Preferably, the weight ratio of described each Chinese crude drug is: Folium Ginkgo 30-70 weight portion, Rhizoma Chuanxiong leaf 30-70 weight portion, Folium Angelicae Sinensis 30-70 weight portion, Leaf of Magnolia officinalis 30-70 weight portion, Folium Mori 20-60 weight portion, Aralia cordata Thunb root 20-60 weight portion.
Preferably, the weight ratio of described each Chinese crude drug is: Folium Ginkgo 40-60 weight portion, Rhizoma Chuanxiong 40-60 weight portion, Folium Angelicae Sinensis 40-60 weight portion, Leaf of Magnolia officinalis 40-60 weight portion, Folium Mori 30-50 weight portion, Aralia cordata Thunb root 30-50 weight portion.
Preferably, the weight ratio of described each Chinese crude drug is: Folium Ginkgo 100 weight portion, Rhizoma Chuanxiong leaf 20 weight portion, Folium Angelicae Sinensis 20 weight portion, Leaf of Magnolia officinalis 20 weight portion, Folium Mori 20 weight portion, Aralia cordata Thunb root 20 weight portion.
Prepare the method with the Chinese medicine paper of antibacterial action described in above-mentioned any one claim, it is characterized in that: it comprises the following steps:
S1: take raw material by above-mentioned weight ratio;
S2: by stock silver Folium Pruni, Rhizoma Chuanxiong leaf, Folium Angelicae Sinensis, Folium Mori, Leaf of Magnolia officinalis, the mixing of Aralia cordata Thunb root, add medical material 20-25 times amount water soaking 1-1.5 hour, then decoct 1-1.5 hour, filter medicinal residues and obtain decocting liquid, medicinal residues discard;
S3: add the decocting liquid in S2 step in the pulping stage in paper-making process, is prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Preferably, Folium Ginkgo extract 10-100 weight portion, Rhizoma Chuanxiong leaf extract 10-100 weight portion, Folium Angelicae Sinensis extract 10-100 weight portion, Leaf of Magnolia officinalis extract 10-100 weight portion, Folium Mori extract 5-80 weight portion, Aralia cordata Thunb root extract 5-80 weight portion.
Preferably, Folium Ginkgo extract 100 weight portion, Rhizoma Chuanxiong leaf extract 20 weight portion, Folium Angelicae Sinensis extract 20 weight portion, Leaf of Magnolia officinalis extract 20 weight portion, Folium Mori extract 20 weight portion, Aralia cordata Thunb root extract 20 weight portion.
The present invention also aims to provide one to prepare Chinese crude drug Preparation Method made of paper, it comprises the following steps:
S1: take raw material by above-mentioned weight ratio;
S2: by stock silver Folium Pruni, Rhizoma Chuanxiong leaf, Folium Angelicae Sinensis, Folium Mori, Leaf of Magnolia officinalis, the mixing of Aralia cordata Thunb root, add medical material 20-25 times amount water soaking 1-1.5 hour, then decoct 1-1.5 hour, filter medicinal residues and obtain decocting liquid, medicinal residues discard;
S3: add the decocting liquid in S2 step in the pulping stage in paper-making process, is prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Folium Ginkgo extract of the present invention, Rhizoma Chuanxiong leaf extract, Folium Angelicae Sinensis extract, Folium Mori extract, Leaf of Magnolia officinalis extract, Aralia cordata Thunb root extract, it is prepared extracting method and any one method conventional such as alcohol reflux, water boiling and extraction, soak extraction, supersound extraction or seepage pressure effects can be selected to extract; Further, crude drug also can purified, refinement treatment after extracting, as crossed macroporous resin column.
The present invention relative to its beneficial effect of prior art is: shown by antibacterial bacteriostatic test, and Chinese crude drug of the present invention has the effect of good anti-bacterial, anti-itching.The preparation method of paper of the present invention adds Chinese medicine mixed liquor on plain paper pulping process, and its preparation method is simple, with low cost, is applicable to industrialized great production.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is described in further detail, but protection scope of the present invention is not limited to the following stated.
Embodiment 1
Take Folium Ginkgo 10kg, Rhizoma Chuanxiong leaf 10kg, Folium Angelicae Sinensis 10kg, Leaf of Magnolia officinalis 10kg, Folium Mori 5kg, Aralia cordata Thunb root 5kg.By stock silver Folium Pruni, Rhizoma Chuanxiong leaf, Folium Angelicae Sinensis, Folium Mori, Leaf of Magnolia officinalis, the mixing of Aralia cordata Thunb root, add medical material 20-25 times amount water soaking 1-1.5 hour, then decoct 1-1.5 hour, filter medicinal residues and obtain decocting liquid, medicinal residues discard; Add decocting liquid in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 2
Take Folium Ginkgo 100kg, Rhizoma Chuanxiong leaf 100kg, Folium Angelicae Sinensis 100kg, Leaf of Magnolia officinalis 100kg, Folium Mori 80kg, Aralia cordata Thunb root 80kg.By stock silver Folium Pruni, Rhizoma Chuanxiong leaf, Folium Angelicae Sinensis, Folium Mori, Leaf of Magnolia officinalis, the mixing of Aralia cordata Thunb root, add medical material 20-25 times amount water soaking 1-1.5 hour, then decoct 1-1.5 hour, filter medicinal residues and obtain decocting liquid, medicinal residues discard; Add decocting liquid in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 3
Take Folium Ginkgo 20kg, Rhizoma Chuanxiong leaf 20kg, Folium Angelicae Sinensis 20kg, Leaf of Magnolia officinalis 20kg, Folium Mori 10kg, Aralia cordata Thunb root 10kg.By stock silver Folium Pruni, Rhizoma Chuanxiong leaf, Folium Angelicae Sinensis, Folium Mori, Leaf of Magnolia officinalis, the mixing of Aralia cordata Thunb root, add medical material 20-25 times amount water soaking 1-1.5 hour, then decoct 1-1.5 hour, filter medicinal residues and obtain decocting liquid, medicinal residues discard; Add decocting liquid in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 4
Take Folium Ginkgo 80kg, Rhizoma Chuanxiong leaf 80kg, Folium Angelicae Sinensis 80kg, Leaf of Magnolia officinalis 80kg, Folium Mori 70kg, Aralia cordata Thunb root 70kg.By stock silver Folium Pruni, Rhizoma Chuanxiong leaf, Folium Angelicae Sinensis, Folium Mori, Leaf of Magnolia officinalis, the mixing of Aralia cordata Thunb root, add medical material 20-25 times amount water soaking 1-1.5 hour, then decoct 1-1.5 hour, filter medicinal residues and obtain decocting liquid, medicinal residues discard; Add decocting liquid in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 5
Take Folium Ginkgo 30kg, Rhizoma Chuanxiong leaf 30kg, Folium Angelicae Sinensis 30kg, Leaf of Magnolia officinalis 30kg, Folium Mori 20kg, Aralia cordata Thunb root 20kg.By stock silver Folium Pruni, Rhizoma Chuanxiong leaf, Folium Angelicae Sinensis, Folium Mori, Leaf of Magnolia officinalis, the mixing of Aralia cordata Thunb root, add medical material 20-25 times amount water soaking 1-1.5 hour, then decoct 1-1.5 hour, filter medicinal residues and obtain decocting liquid, medicinal residues discard; Add decocting liquid in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 6
Take Folium Ginkgo 70kg, Rhizoma Chuanxiong leaf 70kg, Folium Angelicae Sinensis 70kg, Leaf of Magnolia officinalis 70kg, Folium Mori 60kg, Aralia cordata Thunb root 60kg.By stock silver Folium Pruni, Rhizoma Chuanxiong leaf, Folium Angelicae Sinensis, Folium Mori, Leaf of Magnolia officinalis, the mixing of Aralia cordata Thunb root, add medical material 20-25 times amount water soaking 1-1.5 hour, then decoct 1-1.5 hour, filter medicinal residues and obtain decocting liquid, medicinal residues discard; Add decocting liquid in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 7
Take Folium Ginkgo 40kg, Rhizoma Chuanxiong leaf 40kg, Folium Angelicae Sinensis 40kg, Leaf of Magnolia officinalis 40kg, Folium Mori 30kg, Aralia cordata Thunb root 30kg.By stock silver Folium Pruni, Rhizoma Chuanxiong leaf, Folium Angelicae Sinensis, Folium Mori, Leaf of Magnolia officinalis, the mixing of Aralia cordata Thunb root, add medical material 20-25 times amount water soaking 1-1.5 hour, then decoct 1-1.5 hour, filter medicinal residues and obtain decocting liquid, medicinal residues discard; Add decocting liquid in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 8
Take Folium Ginkgo 60kg, Rhizoma Chuanxiong leaf 60kg, Folium Angelicae Sinensis 60kg, Leaf of Magnolia officinalis 60kg, Folium Mori 50kg, Aralia cordata Thunb root 50kg.By stock silver Folium Pruni, Rhizoma Chuanxiong leaf, Folium Angelicae Sinensis, Folium Mori, Leaf of Magnolia officinalis, the mixing of Aralia cordata Thunb root, add medical material 20-25 times amount water soaking 1-1.5 hour, then decoct 1-1.5 hour, filter medicinal residues and obtain decocting liquid, medicinal residues discard; Add decocting liquid in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 9
Take Folium Ginkgo 50kg, Rhizoma Chuanxiong leaf 50kg, Folium Angelicae Sinensis 50kg, Leaf of Magnolia officinalis 50kg, Folium Mori 25kg, Aralia cordata Thunb root 25kg.By stock silver Folium Pruni, Rhizoma Chuanxiong leaf, Folium Angelicae Sinensis, Folium Mori, Leaf of Magnolia officinalis, the mixing of Aralia cordata Thunb root, add medical material 20-25 times amount water soaking 1-1.5 hour, then decoct 1-1.5 hour, filter medicinal residues and obtain decocting liquid, medicinal residues discard; Add decocting liquid in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 10
Take Folium Ginkgo extract 10kg, Rhizoma Chuanxiong leaf extract 10kg, Folium Angelicae Sinensis extract 10kg, Leaf of Magnolia officinalis extract 10kg, Folium Mori extract 5kg, Aralia cordata Thunb root extract 5kg.By raw material Folium Ginkgo extract, Rhizoma Chuanxiong leaf extract, Folium Angelicae Sinensis extract, Folium Mori extract, the mixing of Leaf of Magnolia officinalis extract; Add mixed extract in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 11
Take Folium Ginkgo extract 100kg, Rhizoma Chuanxiong leaf extract 100kg, Folium Angelicae Sinensis extract 100kg, Leaf of Magnolia officinalis extract 100kg, Folium Mori extract 80kg, Aralia cordata Thunb root extract 80kg.By raw material Folium Ginkgo extract, Rhizoma Chuanxiong leaf extract, Folium Angelicae Sinensis extract, Folium Mori extract, the mixing of Leaf of Magnolia officinalis extract; Add mixed extract in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 12
Take Folium Ginkgo extract 100kg, Rhizoma Chuanxiong leaf extract 20kg, Folium Angelicae Sinensis extract 20kg, Leaf of Magnolia officinalis extract 20kg, Folium Mori extract 20kg, Aralia cordata Thunb root extract 50kg.By raw material Folium Ginkgo extract, Rhizoma Chuanxiong leaf extract, Folium Angelicae Sinensis extract, Folium Mori extract, Leaf of Magnolia officinalis extract, the mixing of Aralia cordata Thunb root extract; Add mixed extract in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 13
Take Folium Ginkgo extract 80kg, Rhizoma Chuanxiong leaf extract 80kg, Folium Angelicae Sinensis extract 80kg, Leaf of Magnolia officinalis extract 80kg, Folium Mori extract 70kg, Aralia cordata Thunb root extract 70kg.By raw material Folium Ginkgo extract, Rhizoma Chuanxiong leaf extract, Folium Angelicae Sinensis extract, Folium Mori extract, Leaf of Magnolia officinalis extract, the mixing of Aralia cordata Thunb root extract; Add mixed extract in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 14
Take Folium Ginkgo extract 30kg, Rhizoma Chuanxiong leaf extract 30kg, Folium Angelicae Sinensis extract 30kg, Leaf of Magnolia officinalis extract 30kg, Folium Mori extract 20kg, Aralia cordata Thunb root extract 20kg.By raw material Folium Ginkgo extract, Rhizoma Chuanxiong leaf extract, Folium Angelicae Sinensis extract, Folium Mori extract, Leaf of Magnolia officinalis extract, the mixing of Aralia cordata Thunb root extract; Add mixed extract in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 15
Take Folium Ginkgo extract 50kg, Rhizoma Chuanxiong leaf extract 50kg, Folium Angelicae Sinensis extract 50kg, Leaf of Magnolia officinalis extract 50kg, Folium Mori extract 25kg, Aralia cordata Thunb root extract 20kg.By raw material Folium Ginkgo extract, Rhizoma Chuanxiong leaf extract, Folium Angelicae Sinensis extract, Folium Mori extract, the mixing of Leaf of Magnolia officinalis extract; Add mixed extract in pulping stage in paper-making process, be prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
Embodiment 16
A kind of Chinese medicine paper, this Chinese crude drug is made up of following raw material: Folium Ginkgo 10kg, Rhizoma Chuanxiong leaf 10kg, Folium Angelicae Sinensis 10kg, Leaf of Magnolia officinalis 10kg, Folium Mori 5kg, Aralia cordata Thunb root 5kg.
Embodiment 17
A kind of Chinese medicine paper, this Chinese crude drug is made up of following raw material: Folium Ginkgo 100kg, Rhizoma Chuanxiong leaf 100kg, Folium Angelicae Sinensis 100kg, Leaf of Magnolia officinalis 100kg, Folium Mori 80kg, Aralia cordata Thunb root 80kg.
Embodiment 18
A kind of Chinese medicine paper, this Chinese crude drug is made up of following raw material: Folium Ginkgo 20kg, Rhizoma Chuanxiong leaf 20kg, Folium Angelicae Sinensis 20kg, Leaf of Magnolia officinalis 20kg, Folium Mori 10kg, Aralia cordata Thunb root 10kg.
Embodiment 19
A kind of Chinese medicine paper, this Chinese crude drug is made up of following raw material: Folium Ginkgo 80kg, Rhizoma Chuanxiong leaf 80kg, Folium Angelicae Sinensis 80kg, Leaf of Magnolia officinalis 80kg, Folium Mori 70kg, Aralia cordata Thunb root 70kg.
Embodiment 20
A kind of Chinese medicine paper, this Chinese crude drug is made up of following raw material: Folium Ginkgo 30kg, Rhizoma Chuanxiong leaf 30kg, Folium Angelicae Sinensis 30kg, Leaf of Magnolia officinalis 30kg, Folium Mori 20kg, Aralia cordata Thunb root 20kg.
Embodiment 21
A kind of Chinese medicine paper, this Chinese crude drug is made up of following raw material: Folium Ginkgo 70kg, Rhizoma Chuanxiong leaf 70kg, Folium Angelicae Sinensis 70kg, Leaf of Magnolia officinalis 70kg, Folium Mori 60kg, Aralia cordata Thunb root 60kg.
Embodiment 22
A kind of Chinese medicine paper, this Chinese crude drug is made up of following raw material: Folium Ginkgo 40kg, Rhizoma Chuanxiong leaf 40kg, Folium Angelicae Sinensis 40kg, Leaf of Magnolia officinalis 40kg, Folium Mori 30kg, Aralia cordata Thunb root 30kg.
Embodiment 23
A kind of Chinese medicine paper, this Chinese crude drug is made up of following raw material: Folium Ginkgo 60kg, Rhizoma Chuanxiong leaf 60kg, Folium Angelicae Sinensis 60kg, Leaf of Magnolia officinalis 60kg, Folium Mori 50kg, Aralia cordata Thunb root 50kg.
Embodiment 24
A kind of Chinese medicine paper, this Chinese crude drug is made up of following raw material: Folium Ginkgo 50kg, Rhizoma Chuanxiong leaf 50kg, Folium Angelicae Sinensis 50kg, Leaf of Magnolia officinalis 50kg, Folium Mori 25kg, Aralia cordata Thunb root 25kg.
Embodiment 25
A kind of Chinese medicine paper, this Chinese crude drug is made up of following raw material: Folium Ginkgo extract 10kg, Rhizoma Chuanxiong leaf extract 10kg, Folium Angelicae Sinensis extract 10kg, Leaf of Magnolia officinalis extract 10kg, Folium Mori extract 5kg, Aralia cordata Thunb root extract 5kg.
Embodiment 26
A kind of Chinese medicine paper, this Chinese crude drug is made up of following raw material: Folium Ginkgo extract 100kg, Rhizoma Chuanxiong leaf extract 100kg, Folium Angelicae Sinensis extract 100kg, Leaf of Magnolia officinalis extract 100kg, Folium Mori extract 80kg, Aralia cordata Thunb root extract 80kg.
Embodiment 27
A kind of Chinese medicine paper, this Chinese crude drug is made up of following raw material: Folium Ginkgo extract 100kg, Rhizoma Chuanxiong leaf extract 20kg, Folium Angelicae Sinensis extract 20kg, Leaf of Magnolia officinalis extract 20kg, Folium Mori extract 20kg, Aralia cordata Thunb root extract 20kg.
Beneficial effect of the present invention is proved below by concrete pharmacy test:
This experiment is that detection is a kind of provides medicine decocting liquid in vitro to the bacteriostasis of staphylococcus aureus, escherichia coli, Pseudomonas aeruginosa, proteus vulgaris, Salmonella anatis, Hemolytic streptococcus, candida albicans bacterium seven kinds of antibacterials, fungus.Result is as follows:
One, experiment material
1. medicine: medicine decocting liquid is provided.Concrete preparation method is: take Folium Ginkgo 5kg, Rhizoma Chuanxiong leaf 5kg, Folium Angelicae Sinensis 5kg, Leaf of Magnolia officinalis 5kg, Folium Mori 2.5kg, Aralia cordata Thunb root 2.5kg.By stock silver Folium Pruni, Rhizoma Chuanxiong leaf, Folium Angelicae Sinensis, Folium Mori, Leaf of Magnolia officinalis, the mixing of Aralia cordata Thunb root, add medical material 20-25 times amount water soaking 1-1.5 hour, then decoct 1-1.5 hour, filter medicinal residues and obtain decocting liquid, medicinal residues discard.The medicinal liquid of 1g/ml is prepared into after being concentrated by decocting liquid.
2. bacterial strain: staphylococcus aureus (ATCC25923), escherichia coli (O111B4), Pseudomonas aeruginosa (ATCC27853), proteus vulgaris, Salmonella anatis, Hemolytic streptococcus (ATCC19615), candida albicans bacterium.Above bacterial strain is provided by Chengdu University of Traditional Chinese Medicine's Pathogen Biology and immunology teaching and research room.
3. culture medium: M-H agar culture medium, M-H broth bouillon, M-H serum broth, M-H blood agar culture-medium, glucose Sabouraud's agar culture medium, stand-by by side's preparation, subpackage, sterilizing.
Other: aseptic measuring pipette, sterile petri dish, physiological saline solution, sterile test tube, aseptic Sanguis Leporis seu oryctolagi etc.
Two, experimental technique
Antibacterial bacteriostatic test: because provided medicine decocting liquid is dark brown, color is very dark, therefore adopts agar two times of serial dilutions.
(1) bacterium liquid prepares
(1) staphylococcus aureus, escherichia coli, Pseudomonas aeruginosa, proteus vulgaris, Salmonella anatis are inoculated in M-H nutrient agar panel respectively, activation.The single colonies typical of picking is inoculated in M-H meat soup pipe, and put 37 DEG C of incubators and cultivate 24h, counting, is diluted to 1 × 107cfu/ml with physiological saline solution by bacterium liquid.
(2) Hemolytic streptococcus is inoculated in the activation of M-H blood agar plate.The single colonies typical of picking is inoculated in serum broth pipe, and put 37 DEG C of incubators and cultivate 24h, counting, is diluted to 1 × 107cfu/ml with physiological saline solution by bacterium liquid.
(2) culture medium prepares
(1) medicine decocting liquid will be provided to examine product to be joined in the aseptic M-H nutrient agar of thermosol, be mixed with each concentration M-H agar plate that drug dilution degree is 1/2.5,1/5,1/10,1/20,1/40,1/80,1/160,1/320,1/640,1/1280, stand-by after sterility test.
(2) medicine decocting liquid will be provided to examine product to be joined in the aseptic M-H agar culture medium of thermosol, add 10% aseptic Sanguis Leporis seu oryctolagi again, be mixed with drug dilution degree be 1/2.5,1/5,1/10,1/20,1/40,1/80,1/160,1/320,1/640,1/1280 each concentration M-H blood agar plate stand-by.
(3) inoculate
(1) the staphylococcus aureus of above-mentioned concentration, escherichia coli, Pseudomonas aeruginosa, Salmonella anatis bacterium liquid inoculating loop picking 1 ring are inoculated in the above-mentioned M-H agar plate providing medicine decocting liquid inspection product containing variable concentrations respectively, put 37 DEG C and cultivate 24h, observed result.
(2) proteus vulgaris bacterium liquid inoculating loop picking 1 ring of above-mentioned concentration is inoculated in respectively the above-mentioned M-H agar plate that medicine decocting liquid inspection product are provided containing variable concentrations, puts 37 DEG C and cultivate 24h, observed result.
(3) above-mentioned certain density Hemolytic streptococcus bacterium liquid inoculating loop is chosen 1 ring and be inoculated in the above-mentioned M-H blood agar plate that medicine decocting liquid inspection product are provided containing variable concentrations respectively, put 37 DEG C and cultivate 24h, observed result.
Three, fungus bacteriostatic experiment
(1) bacterium liquid prepares
Candida albicans bacterium is inoculated in Sabouraud's agar flat board, cultivates 4 days for 28 DEG C.Picking colonies typical, in sterile grinder, with physiological saline solution grinding, counts its mycelia and sporozoite number, with physiological saline solution, bacterium liquid is diluted to 1 × 107cfu/ml.
(2) culture medium prepares
Medicine decocting liquid will be provided to examine product join in the weak culture medium in the aseptic husky fort of thermosol, be mixed with drug dilution degree be 1/2.5,1/5,1/10,1/20,1/40,1/80,1/160,1/320,1/640,1/1280 the weak agar plate in the husky fort of each concentration stand-by.
(3) bacterium liquid is added
Above-mentioned certain density candida albicans bacterium bacterium liquid inoculating loop picking 1 ring is inoculated in respectively the above-mentioned Sabouraud's agar flat board providing medicine decocting liquid to examine product containing variable concentrations, puts 28 DEG C and cultivate 3 days, observed result.
(4) experimental result
(1) the bacteriostatic experiment result of medicine decocting liquid to seven kinds of antibacterials, fungus is provided to the results are shown in Table 1.
Table 1 provides medicine decocting liquid to the bacteriostasis of seven kinds of antibacterials
+: bacterial growth;-: antibacterial does not grow; MIC: minimal inhibitory concentration
(2) provide medicine decocting liquid to the minimal inhibitory concentration of seven kinds of antibacterials, fungus
The results are shown in Table 2
Table 2 provides medicine decocting liquid to the minimal inhibitory concentration of seven kinds of antibacterials, fungus
Note: Hemolytic streptococcus is female and bacterium candida albicans bacterium is insensitive to providing medicine decocting liquid 400mg/ml (1/2.5) concentration, namely this medicine in 400mg/ml (1/2.5) concentration to above-mentioned two kinds of bacterium without bacteriostasis.
Show by experiment, Chinese crude drug of the present invention has good anti-bacterial, anti-itching, antianaphylactic effect.In addition, cause mouse writhing reaction experiment, mice caused by dimethylbenzene xylene ear swelling test shows by glacial acetic acid, Chinese crude drug compositions of the present invention also has the effect of anti-inflammatory and antalgic.The preparation method of paper of the present invention adds Chinese medicine mixed liquor on plain paper pulping process, and its preparation method is simple, with low cost, is applicable to industrialized great production.
Claims (8)
1. there is a Chinese medicine paper for antibacterial action, it is characterized in that: described Chinese crude drug is made up of following raw material and weight ratio: Folium Ginkgo 10-100 weight portion, Rhizoma Chuanxiong leaf 10-100 weight portion, Folium Angelicae Sinensis 10-100 weight portion, Leaf of Magnolia officinalis 10-100 weight portion, Folium Mori 5-80 weight portion, Aralia cordata Thunb root 5-80 weight portion.
2. a kind of Chinese medicine paper with antibacterial action according to claim 1, is characterized in that: the weight ratio of described each Chinese crude drug is: Folium Ginkgo 20-80 weight portion, Rhizoma Chuanxiong leaf 20-80 weight portion, Folium Angelicae Sinensis 20-80 weight portion, Leaf of Magnolia officinalis 20-80 weight portion, Folium Mori 10-70 weight portion, Aralia cordata Thunb root 10-70 weight portion.
3. a kind of Chinese medicine paper with antibacterial action according to claim 1, is characterized in that: the weight ratio of described each Chinese crude drug is: Folium Ginkgo 30-70 weight portion, Rhizoma Chuanxiong leaf 30-70 weight portion, Folium Angelicae Sinensis 30-70 weight portion, Leaf of Magnolia officinalis 30-70 weight portion, Folium Mori 20-60 weight portion, Aralia cordata Thunb root 20-60 weight portion.
4. a kind of Chinese medicine paper with antibacterial action according to claim 1, is characterized in that: the weight ratio of described each Chinese crude drug is: Folium Ginkgo 40-60 weight portion, Rhizoma Chuanxiong 40-60 weight portion, Folium Angelicae Sinensis 40-60 weight portion, Leaf of Magnolia officinalis 40-60 weight portion, Folium Mori 30-50 weight, Aralia cordata Thunb root 30-50 weight portion.
5. a kind of Chinese medicine paper with antibacterial action according to claim 1, is characterized in that: the weight ratio of described each Chinese crude drug is: Folium Ginkgo 100 weight portion, Rhizoma Chuanxiong leaf 20 weight portion, Folium Angelicae Sinensis 20 weight portion, Leaf of Magnolia officinalis 20 weight portion, Folium Mori 20 weight portion, Aralia cordata Thunb root 20 weight portion.
6. prepare the method with the Chinese medicine paper of antibacterial action in Claims 1 to 5 described in any one claim, it is characterized in that: it comprises the following steps:
S1: take raw material by above-mentioned weight ratio;
S2: by stock silver Folium Pruni, Rhizoma Chuanxiong leaf, Folium Angelicae Sinensis, Folium Mori, Cortex Magnoliae Officinalis, the mixing of Aralia cordata Thunb root leaf, add medical material 20-25 times amount water soaking 1-1.5 hour, then decoct 1-1.5 hour, filter medicinal residues and obtain decocting liquid, medicinal residues discard;
S3: add the decocting liquid in S2 step in the pulping stage in paper-making process, is prepared into the Chinese medicine paper with antibacterial action through the modulation of conventional paper-making technique, paper-making process.
7. there is a Chinese medicine paper for antibacterial action, it is characterized in that: Chinese crude drug is made up of following raw material and weight ratio: Folium Ginkgo extract 10-100 weight portion, Rhizoma Chuanxiong leaf extract 10-100 weight portion, Folium Angelicae Sinensis extract 10-100 weight portion, Leaf of Magnolia officinalis extract 10-100 weight portion, Folium Mori extract 5-80 weight portion, Aralia cordata Thunb root extract 5-80 weight portion.
8. a kind of Chinese medicine paper with antibacterial action according to claim 7, is characterized in that: the weight ratio of described each Chinese crude drug is: Folium Ginkgo extract 100 weight portion, Rhizoma Chuanxiong leaf extract 20 weight portion, Folium Angelicae Sinensis extract 20 weight portion, Leaf of Magnolia officinalis extract 20 weight portion, Folium Mori extract 20 weight portion, Aralia cordata Thunb root extract 20 weight portion.
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