CN104840701A - Gel for treating vaginitis - Google Patents
Gel for treating vaginitis Download PDFInfo
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- CN104840701A CN104840701A CN201510293942.8A CN201510293942A CN104840701A CN 104840701 A CN104840701 A CN 104840701A CN 201510293942 A CN201510293942 A CN 201510293942A CN 104840701 A CN104840701 A CN 104840701A
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Abstract
The invention belongs to the technical field of a traditional Chinese medicine preparation, and particularly discloses gel. The gel is prepared from the following components in parts by weight: 20 parts of raspberry pear, 15 parts of burmann cinnamon root, 18 parts of leaf of chinaroot greenbrier, 20 parts of love-lies-bleeding root, 16 parts of white baneberry, 14 parts of rangoon creeper root, 13 parts of roughhair fig root, 20 parts of all-grass of shiningfruit night-shade, 18 parts of water boxwood, 2 parts of carbomer, 25 parts of propylene glycol, 2 parts of ethyl alcohol, 2 parts of azone, 3 parts of triethanolamine and 150 parts of distilled water. The gel has functions of dispelling wind and arresting itching, and removing dampness and destroying parasites, and is used for treating vaginitis.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to one and treat colpitic gel and its preparation method and application.
Background technology
To colpitic treatment, Chinese and western medicine has his own strong points, western medicine instant effect, but easily produces drug resistance, often the recurrent exerbation because treatment is not thorough; Treatment by Chinese herbs takes effect slowly, but curative effect is more stable, and side effect is little.Market lacks the gel with better effects.
Summary of the invention
The object of the invention is open a kind of good effect, easy to use, the colpitic gel for the treatment of that side effect is little.
Another object of the present invention is to provide preparation method and the purposes of this Traditional Chinese medicinal gel preparation.
The present invention is achieved through the following technical solutions:
One treats colpitic gel, extracted by following bulk drugs and adjuvant weight and be prepared from: Radix seu Folium pruni eglandulosae 20 parts, Radix Cinnamomi Burmanni 15 parts, Folium smilacis chinensis 18 parts, Radix Amaranthi Caudati 20 parts, Radix Delphinii pogonanthi 16 parts, Radix Quisqualis 14 parts, Radix Fici Hirtae 13 parts, Herba solani photeinocarpi 20 parts, Radix Polygalae Caudatae 18 parts, carbomer 2 parts, propylene glycol 25 parts, ethanol 2 parts, azone 2 parts, triethanolamine 3 parts, distilled water 150 parts.
The colpitic gel of described treatment, preparation method comprises the steps:. gets above-mentioned medical material, decocts 2 times, add weight 12 times amount soak by water 2 hours at every turn, filter, merging filtrate, when being evaporated to 70 DEG C, relative density is 1.1, add ethanol to the volume ratio of alcohol content and reach 60%, leave standstill 48 hours, filter, collect filtrate, decompression recycling ethanol, and filtrate is concentrated into 70 DEG C time, often rise volume concentrated solution containing the concentrated solution of crude drug amount 2kg, obtain extraction concentrated solution; Get carbomer adding distil water fully swelling, get extraction concentrated solution and add wherein, stir and make into gel-type vehicle; Add propylene glycol, azone mix homogeneously, getting triethanolamine adjust ph is 5.0, stirs and get final product.
The application of the colpitic gel of described treatment in preparation treatment colpitis medicine.
Radix seu Folium pruni eglandulosae is the root of rosaceous plant Radix seu Folium pruni eglandulosae, leaf, really.Radix Cinnamomi Burmanni is the cloudy fragrant root of canella.Folium smilacis chinensis is the blade of liliaceous plant Rhizoma Smilacis Chinensis.Radix Amaranthi Caudati is the root of Herba Amaranthi tricoloris kind of plant love-lies-bleeding.Radix Delphinii pogonanthi is the root that ranunculaceae plant must spend Herba delphinii grandiflori.Radix Quisqualis is the root of Combretum Racemosum plant Fructus Quisqualis.Radix Polygalae Caudatae is the root of milk wort caudal lobe Radix Polygalae.Herba solani photeinocarpi is the herb of plant of Solanaceae S. photeinocarpum.Radix Tongoloae Dunnii is the root of samphire Flos Carthami celery.Radix Fici Hirtae is root or the root bark of moraceae plants palm leaf banyan.
Prescription of the present invention is monarch drug by Radix seu Folium pruni eglandulosae, Radix Cinnamomi Burmanni, Folium smilacis chinensis, Radix Amaranthi Caudati, Radix Delphinii pogonanthi heat-clearing and toxic substances removing, Radix Quisqualis, Radix Fici Hirtae parasite killing are ministerial drug, Herba solani photeinocarpi, Radix Polygalae Caudatae are adjuvant, by above-mentioned all medicine compatibilities, full side has effect of heat-clearing and toxic substances removing, dispelling wind for relieving itching, removing dampness and killing parasites, for vaginitis.
Detailed description of the invention
Embodiment 1: get Radix seu Folium pruni eglandulosae 20g, Radix Cinnamomi Burmanni 15g, Folium smilacis chinensis 18g, Radix Amaranthi Caudati 20g, Radix Delphinii pogonanthi 16g, Radix Quisqualis 14g, Radix Fici Hirtae 13g, Herba solani photeinocarpi 20g, Radix Polygalae Caudatae 18g, carbomer 2g, propylene glycol 25g, ethanol 2g, azone 2g, triethanolamine 3g, distilled water 150g, get the above-mentioned palm and split Flos Begoniae Evansianae, Shi Shanglian, wild seat grass, Herba Swertiae davidi, Drymoglossum Herba Drymoglossi medical material, decoct 2 times, add weight 12 times amount soak by water 2 hours at every turn, filter, merging filtrate, when being evaporated to 70 DEG C, relative density is 1.1, add ethanol to the volume ratio of alcohol content and reach 60%, leave standstill 48 hours, filter, collect filtrate, decompression recycling ethanol, and filtrate is concentrated into the concentrated solution that often rises volume the 70 DEG C time concentrated solution containing crude drug amount 2kg, concentrated solution must be extracted, get carbomer adding distil water fully swelling, get extraction concentrated solution and add wherein, stir and make into gel-type vehicle, add propylene glycol, azone mix homogeneously, getting triethanolamine adjust ph is 5.0, stirs and get final product.
2. pharmacological evaluation of the present invention
2.1 extracorporeal bacteria inhibitor tests of the present invention
Test objective: adopt certain culture medium to cultivate the vaginal bacteria be recently separated or mycete, observe In Vitro Bacteriostasis of the present invention, and measure its minimum antibacterial crude drug consumption concentration.
2.1.1 test material
(1) medicine and reagent
By reagent: prepare gel by above-mentioned preparation embodiment 1 method, be the present invention: specification: 2g crude drug/g, lot number: 20120503; Sodium chloride: Shanghai hundred million chemical reagent company limiteies of a specified duration, lot number: 00060120.Nutrient broth medium: CAS Shanghai Insect Bio Technological Development Co., Ltd., lot number: 110516.Nutrient agar: microorganism reagent factory of Jiangsu Prov. Disease Preventing and Controlling Center, lot number: 110016.Improvement Martin culture medium: sky, Hangzhou and microorganism reagent company limited, lot number: 100831.Improvement Martin culture medium: Beijing three medicine scientific and technological development company, lot number: 111213; Sabouraud's agar: Beijing Luqiao Technology Co., Ltd. of China Inst. of Quarantine Inspection Sciences, lot number: 1007153; Calf serum, Hangzhou Sijiqing Biological Engineering Material Co., Ltd., lot number: 100508; De-fine Sheep Blood, purchased from Jiangning county epidemic prevention station, lot number: 120312
(2) bacterial strain
Reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210) are provided by Disease epizootic prevention center microorganism reagent factory of Jiangsu Province; Candida albicans (98100) is provided by institute for drug control, Jiangsu Province.
(3) instrument and equipment
Electronic balance, Beijing Sai Duolisi balance company limited produces; Full-automatic high-pressure autoclave, Japanese SANYO;
Superclean bench, Suzhou Decontamination Equipment Plant; SHP-80 biochemical cultivation case, Shanghai is gloomy reliablely tests Instrument Ltd.
2.1.2 experimental technique
(1) antibacterial culturing
Get reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210) bacterial strain a little, are inoculated in nutrient broth medium respectively, cultivate 18h for 37 DEG C.(adding 20% calf serum in group B streptococcus broth bouillon) gets each bacterial strain nutrient broth culture that 18h cultivates, and does 10-3 dilution for experiment with nutrient broth.Extracting waste candidiasis bacterial strain is a little, is inoculated in improvement Martin culture medium, cultivates 24h for 35 DEG C.Get the Candida albicans culture that 24h cultivates, be used for experiment with improvement Martin culture medium 10-3 dilution.
(2) doubling dilution (test tube method)
Get sterilizing test tubes 11, the 1st pipe adds nutrient broth fluid medium 1.6ml, and all the other are pipe 1ml often, get respectively and add in the first pipe by reagent diluent 0.4ml, get 1ml after mixing to the 2nd pipe, dilute successively, 10th pipe sucking-off 1ml discards, and the 11st pipe does not add medicinal liquid in contrast.Often pipe adds dilution bacterium liquid 0.1ml, cultivates 24h for 37 DEG C.Take out and observe bacterial growth situation.As drug liquid tube is muddy, namely represent bacterial growth, for reagent thing without bacteriostasis; As drug liquid tube is limpid, represent that bacterial growth is suppressed, the medicinal liquid of the greatest dilution of its energy bacteria growing inhibiting, is the minimal inhibitory concentration (MIC) of this medicine.By limpid medicinal liquid meat soup each pipe transferred species broth agar plates, cultivate 24h and observe, be still the bacteriocidal concentration of this medicine without the minimum drug level of bacterial growth.
Get sterilizing test tubes 11, the 1st pipe adds improvement Martin fluid medium 1.6ml, and all the other are pipe 1ml often, get respectively and add in the first pipe by reagent diluent 0.4ml, get 1ml after mixing to the 2nd pipe, dilute successively, 10th pipe sucking-off 1ml discards, and the 11st pipe does not add medicinal liquid in contrast.Often pipe adds dilution bacterium liquid 0.1ml, cultivates 24h for 35 DEG C, takes out and observe bacterial growth situation.As drug liquid tube is muddy, namely represent bacterial growth, for reagent thing without bacteriostasis; As drug liquid tube is limpid, represent that bacterial growth is suppressed, the medicinal liquid of the greatest dilution of its energy bacteria growing inhibiting, is the minimal inhibitory concentration (MIC) of this medicine.Limpid medicinal liquid meat soup each pipe transferred species sabouraud's agar is dull and stereotyped, cultivate 24h and observe, be still the bacteriocidal concentration of this medicine without the minimum drug level of bacterial growth.
2.1.3 result
Experimental result shows: the present invention is to reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210), Candida albicans all have stronger bacteriostasis, and MIC is at 02g ~ 0.5g/g (by raw medicine calculation).In table 1.
Table 1 antibacterial activity in vitro of the present invention (n=2)
Bacterial strain | Minimum inhibitory concentration (MIC) (g crude drug/g) |
Staphylococcus aureus (standard) | 0.3 |
Escherichia coli (standard) | 0.3 |
Group B streptococcus (standard) | 0.2 |
Candida albicans | 0.5 |
2.1.4 conclusion: the present invention has good bacteriostasis, can be used for treating vaginitis.
Claims (3)
1. the colpitic gel for the treatment of, it is characterized in that being extracted by following bulk drugs and adjuvant weight being prepared from: Radix seu Folium pruni eglandulosae 20 parts, Radix Cinnamomi Burmanni 15 parts, Folium smilacis chinensis 18 parts, Radix Amaranthi Caudati 20 parts, Radix Delphinii pogonanthi 16 parts, Radix Quisqualis 14 parts, Radix Fici Hirtae 13 parts, Herba solani photeinocarpi 20 parts, Radix Polygalae Caudatae 18 parts, carbomer 2 parts, propylene glycol 25 parts, ethanol 2 parts, azone 2 parts, triethanolamine 3 parts, distilled water 150 parts.
2. treat colpitic gel as claimed in claim 1, it is characterized in that preparation method comprises the steps:. get above-mentioned medical material, decoct 2 times, add weight 12 times amount soak by water 2 hours at every turn, filter, merging filtrate, when being evaporated to 70 DEG C, relative density is 1.1, add ethanol to the volume ratio of alcohol content and reach 60%, leave standstill 48 hours, filter, collect filtrate, decompression recycling ethanol, and filtrate is concentrated into 70 DEG C time, often rise volume concentrated solution containing the concentrated solution of crude drug amount 2kg, obtain extraction concentrated solution; Get carbomer adding distil water fully swelling, get extraction concentrated solution and add wherein, stir and make into gel-type vehicle; Add propylene glycol, azone mix homogeneously, getting triethanolamine adjust ph is 5.0, stirs and get final product.
3. treat the application of colpitic gel in treatment colpitis medicine as claimed in claim 1.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106177454A (en) * | 2016-07-18 | 2016-12-07 | 南京正宽医药科技有限公司 | One treats colpitic gel and preparation method thereof |
CN107982360A (en) * | 2017-12-06 | 2018-05-04 | 苏州兰灵医药科技有限公司 | A kind of gelling agent and its application method for being used to treat vaginitis |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100899639B1 (en) * | 2008-09-01 | 2009-05-27 | 신라대학교 산학협력단 | An antibacterial composition comprising an extract of ulva pertusa and composition comprising the antibacterial composition for treatment of vaginosis |
CN102793881A (en) * | 2012-09-07 | 2012-11-28 | 南京市妇幼保健院 | Traditional Chinese medicine gel for treating vaginitis as well as preparation method and application of traditional Chinese medicine gel |
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2015
- 2015-06-01 CN CN201510293942.8A patent/CN104840701A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100899639B1 (en) * | 2008-09-01 | 2009-05-27 | 신라대학교 산학협력단 | An antibacterial composition comprising an extract of ulva pertusa and composition comprising the antibacterial composition for treatment of vaginosis |
CN102793881A (en) * | 2012-09-07 | 2012-11-28 | 南京市妇幼保健院 | Traditional Chinese medicine gel for treating vaginitis as well as preparation method and application of traditional Chinese medicine gel |
Non-Patent Citations (1)
Title |
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王婉萍等: "苦参凝胶治疗细菌性阴道炎40例", 《实用医学杂志》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106177454A (en) * | 2016-07-18 | 2016-12-07 | 南京正宽医药科技有限公司 | One treats colpitic gel and preparation method thereof |
CN107982360A (en) * | 2017-12-06 | 2018-05-04 | 苏州兰灵医药科技有限公司 | A kind of gelling agent and its application method for being used to treat vaginitis |
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