CN104825744A - Traditional Chinese medicine gel for treating vaginitis as well as preparation method and application of traditional Chinese medicine gel - Google Patents
Traditional Chinese medicine gel for treating vaginitis as well as preparation method and application of traditional Chinese medicine gel Download PDFInfo
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- CN104825744A CN104825744A CN201510257492.7A CN201510257492A CN104825744A CN 104825744 A CN104825744 A CN 104825744A CN 201510257492 A CN201510257492 A CN 201510257492A CN 104825744 A CN104825744 A CN 104825744A
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Abstract
The invention belongs to the field of traditional Chinese medicines, and particularly discloses traditional Chinese medicine gel for treating vaginitis. The traditional Chinese medicine gel is prepared from the following raw material medicines and auxiliary materials in parts by weight: 18 parts of kalanchoe laciniata, 15 parts of clerodendronserratum, 12 parts of maianthemum bifolium, 15 parts of veronica ciliate, 12 parts of piperwallichii, 15 parts of sida acuta, 1 part of carbomer, 20 parts of propylene glycol, 2 parts of ethanol, 2 parts of azone, 3 parts of triethanolamine and 250 parts of distilled water. The traditional Chinese medicine gel can be used for treating vaginitis.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to one and treat colpitic Chinese medicine gel and its preparation method and application.
Background technology
Vaginitis sickness rate is higher, has a strong impact on physical and mental health and the quality of life of patient, in the urgent need to determined curative effect, and medicine easy to use, safe.Vaginitis is one of women's frequently-occurring disease, has a strong impact on their quality of life, and its treatment is transitioned into low dosage vagina administration gradually by whole body estrin treatment in the past.To colpitic treatment, Chinese and western medicine has his own strong points, western medicine instant effect, but easily produces drug resistance, often the recurrent exerbation because treatment is not thorough; Treatment by Chinese herbs takes effect slowly, but curative effect is more stable, and side effect is little.Current shortage effectively treats colpitic Chinese medicine gel.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide one to treat colpitic Chinese medicine gel and its preparation method and application.
Technical scheme: the object of the invention is by following scheme realize:
One treats colpitic Chinese medicine gel, extracted by following bulk drugs and adjuvant weight and be prepared from: Herba Kalanchoes Laciniatae 18 parts, three is to 15 parts, joint, Herba Maianthemi Bifolii 12 parts, Herba Veronicae Ciliatae 15 parts, Caulis et Folium piperis 12 parts, Radix sidae acutae 15 parts, carbomer 1 part, propylene glycol 20 parts, ethanol 2 parts, azone 2 parts, triethanolamine 3 parts, distilled water 250 parts.
The colpitic Chinese medicine gel of described treatment, preparation method comprises the steps:. gets the mixing of above-mentioned Chinese medicine, decocts 2 times, add medical material weight 10 times of water gagings, each decoction 2 hours, filters at every turn, merging filtrate, when being evaporated to 70 DEG C, relative density is 1.1, adds ethanol to the volume ratio of alcohol content and reaches 75%, leave standstill 48 hours, filter, collect filtrate, decompression recycling ethanol, and filtrate is concentrated into 70 DEG C time, often rise volume concentrated solution containing the concentrated solution of crude drug amount 2kg, obtain Chinese medicine extraction concentrated solution; Getting carbomer, to add appropriate distilled water fully swelling, adds propylene glycol, ethanol, azone, use triethanolamine adjust ph, stir and get final product.
The colpitic Chinese medicine gel of described treatment, its pH value range is at 4.5-5.5.
The application of the colpitic Chinese medicine gel of described treatment in preparation treatment colpitis medicine.
In the present invention, Folium Isatidis wood is Verbena officinalis Ke Cheng paulownia platymiscium Folium Isatidis wood Clerodendron cyrtophyllum Turcz., is used as medicine with root, leaf.Clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For preventing and treating epidemic cerebrospinal meningitis, epidemic encephalitis type B, cure cold headache, measles complicated pneumonia, mumps, tonsillitis, infectious hepatitis, dysentery, urinary tract infection.
Three pairs of joints, Classification system Clerodendrum serratum is Verenaceae shrub.Herb is containing Saponin.Have preventing the attack (or recurrence) of malaria, refute bone, sterilization, heat clearing away, the effect such as removing toxic substances.Yunnan, Guangxi are mainly used in preventing and treating malaria, dysentery, synthetism; Also the diseases such as headache, ophthalmia, traumatic injury, rheumatism are controlled; Decoct water in right amount with fresh leaf can to harness the Yellow River chickenpox.Heat-clearing and toxic substances removing, preventing the attack (or recurrence) of malaria, synthetism, expelling wind and removing dampness.For tonsillitis, pharyngolaryngitis, rheumatic ostalgia, malaria, hepatitis; Carbuncle furuncle and phyma poison is controlled in external, fracture, traumatic injury.
Herba Maianthemi Bifolii is the herb of liliaceous plant Herba Maianthemi Bifolii, cooling blood for hemostasis, heat-clearing and toxic substances removing, main haematemesis, hematuria, menorrhagia, traumatic hemorrhage, sore, carbuncle and painful swelling.Classification system is Maianthemum bifolium (L.) Fr.Schmidt.
Herba Veronicae Ciliatae is Scrophulariaceae brooklime Herba Veronicae ciliatae Veronica ciliata Fisch., with all herbal medicine, and heat-clearing and toxic substances removing, expelling wind and removing dampness.For hepatitis, cholecystitis, rheumatalgia, urticaria.
Caulis et Folium piperis is stem and leaf or the Herb of Piperaceae plant Caulis et Folium piperis Piperwallichii (Niq.) Hand.Maz z.var.hupenense (DC.) Hand.Mazz.: wind-damp dispelling, strong waist knee joint, pain relieving, cough-relieving.For rheumatic arthralgia, bruise, weakness of the waist and knees, dysmenorrhea, anemofrigid cold, cough and asthma, the present invention is used as medicine with Herb.
Radix sidae acutae, formal name used at school: Sida acuta Burm.F, Malvaceae, a kind under chrysanthemum harvest spp.Upright suffruticose draft, branch is many, and sprig is extremely near without hair by pubescence.Leaf lanceolar, base portion circle or blunt, tool sawtooth, petiole is dredged by pubescence; Stipule is linear, closely isometric with petiole, Chang Sucun.Hua Danduo or be born in axil in pairs, stamen is dredged by bristle.The nearly spheroidal of capsule, florescence winter-spring season.Often be born between the shrubbery of hillside, roadside or barren hill.Clearing away heat-damp and promoting diuresis, evacuation of pus pain relieving.For cold, fever, tonsillitis, bacillary dysentery, urinary system calculus, jaundice, dysentery, abdominal pain pain; Carbuncle furuncle furuncle is controlled in external.The present invention is with all herbal medicine.
Herba Kalanchoes Laciniatae is the herb of crassulaceae plants Herba Kalanchoes Laciniatae.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For traumatic injury, venom, skin infection abscess, burn and scald, eczema, traumatic hemorrhage.
Beneficial effect:
Folium Isatidis wood of the present invention, three is to joint, Herba Maianthemi Bifolii heat-clearing and toxic substances removing, and parasite killing is monarch drug, and Herba Veronicae Ciliatae, Caulis et Folium piperis, Radix sidae acutae are ministerial drug, and Herba Kalanchoes Laciniatae is adjuvant, cooperatively interacts, and is prepared into medicament, can treat vaginitis.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1: claim Herba Kalanchoes Laciniatae 18g, three couples of joint 15g, Herba Maianthemi Bifolii 12g, Herba Veronicae Ciliatae 15g, Caulis et Folium piperis 12g, Radix sidae acutae 15g, carbomer 1g, propylene glycol 20g, ethanol 2g, azone 2g, triethanolamine 3g, distilled water 250g, get the mixing of above-mentioned Chinese medicine, decoct 2 times, add medical material weight 10 times of water gagings at every turn, each decoction 2 hours, filter, merging filtrate, when being evaporated to 70 DEG C, relative density is 1.1, add ethanol to the volume ratio of alcohol content and reach 75%, leave standstill 48 hours, filter, collect filtrate, decompression recycling ethanol, and filtrate is concentrated into the concentrated solution that often rises volume the 70 DEG C time concentrated solution containing crude drug amount 2kg, obtain Chinese medicine extraction concentrated solution, getting carbomer, to add appropriate distilled water fully swelling, and adding propylene glycol, ethanol, azone, is 4.5 by triethanolamine adjust ph, stirs and get final product.
Embodiment 2: claim Herba Kalanchoes Laciniatae 18g, three couples of joint 15g, Herba Maianthemi Bifolii 12g, Herba Veronicae Ciliatae 15g, Caulis et Folium piperis 12g, Radix sidae acutae 15g, carbomer 1g, propylene glycol 20g, ethanol 2g, azone 2g, triethanolamine 3g, distilled water 250g, get the mixing of above-mentioned Chinese medicine, decoct 2 times, add medical material weight 10 times of water gagings at every turn, each decoction 2 hours, filter, merging filtrate, when being evaporated to 70 DEG C, relative density is 1.1, add ethanol to the volume ratio of alcohol content and reach 75%, leave standstill 48 hours, filter, collect filtrate, decompression recycling ethanol, and filtrate is concentrated into the concentrated solution that often rises volume the 70 DEG C time concentrated solution containing crude drug amount 2kg, obtain Chinese medicine extraction concentrated solution, getting carbomer, to add appropriate distilled water fully swelling, and adding propylene glycol, ethanol, azone, use triethanolamine adjust ph, is 5.5, stirs and get final product.
Embodiment 3: claim Herba Kalanchoes Laciniatae 18g, three couples of joint 15g, Herba Maianthemi Bifolii 12g, Herba Veronicae Ciliatae 15g, Caulis et Folium piperis 12g, Radix sidae acutae 15g, carbomer 1g, propylene glycol 20g, ethanol 2g, azone 2g, triethanolamine 3g, distilled water 250g, get the mixing of above-mentioned Chinese medicine, decoct 2 times, add medical material weight 10 times of water gagings at every turn, each decoction 2 hours, filter, merging filtrate, when being evaporated to 70 DEG C, relative density is 1.1, add ethanol to the volume ratio of alcohol content and reach 75%, leave standstill 48 hours, filter, collect filtrate, decompression recycling ethanol, and filtrate is concentrated into the concentrated solution that often rises volume the 70 DEG C time concentrated solution containing crude drug amount 2kg, obtain Chinese medicine extraction concentrated solution, getting carbomer, to add appropriate distilled water fully swelling, and adding propylene glycol, ethanol, azone, use triethanolamine adjust ph, is 5.0, stirs and get final product.
Embodiment 4, extracorporeal bacteria inhibitor test of the present invention: adopt certain culture medium to cultivate the vaginal bacteria be recently separated or mycete, observe In Vitro Bacteriostasis of the present invention, and measure its minimum antibacterial crude drug consumption concentration.
(1) medicine and reagent
By reagent: prepare Chinese medicine gel by above-mentioned preparation embodiment 2 method, be the present invention: specification: 3g crude drug/g, lot number: 20140603; Sodium chloride: Shanghai hundred million chemical reagent company limiteies of a specified duration, lot number: 00070120.Nutrient broth medium: CAS Shanghai Insect Bio Technological Development Co., Ltd., lot number: 130516.Nutrient agar: microorganism reagent factory of Jiangsu Prov. Disease Preventing and Controlling Center, lot number: 120016.Improvement Martin culture medium: sky, Hangzhou and microorganism reagent company limited, lot number: 110831.Improvement Martin culture medium: Beijing three medicine scientific and technological development company, lot number: 121213; Sabouraud's agar: Beijing Luqiao Technology Co., Ltd. of China Inst. of Quarantine Inspection Sciences, lot number: 1007153; Calf serum, Hangzhou Sijiqing Biological Engineering Material Co., Ltd., lot number: 100508; De-fine Sheep Blood, purchased from Jiangning county epidemic prevention station, lot number: 130312
(2) bacterial strain
Reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210) are provided by Disease epizootic prevention center microorganism reagent factory of Jiangsu Province; Candida albicans (98100) is provided by institute for drug control, Jiangsu Province.
(3) instrument and equipment
Electronic balance, Beijing Sai Duolisi balance company limited produces; Full-automatic high-pressure autoclave, Japanese SANYO; Superclean bench, Suzhou Decontamination Equipment Plant; SHP-80 biochemical cultivation case, Shanghai is gloomy reliablely tests Instrument Ltd.
(4) experimental technique
Antibacterial culturing: get reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210) bacterial strain are a little, be inoculated in respectively in nutrient broth medium, cultivate 18h for 37 DEG C.(adding 20% calf serum in group B streptococcus broth bouillon) gets each bacterial strain nutrient broth culture that 18h cultivates, and does 10 with nutrient broth
-3dilution is used for experiment.Extracting waste candidiasis bacterial strain is a little, is inoculated in improvement Martin culture medium, cultivates 24h for 35 DEG C.Get the Candida albicans culture that 24h cultivates, by improvement Martin culture medium 10
-3dilution is used for experiment.
Doubling dilution (test tube method): get sterilizing test tubes 11,1st pipe adds nutrient broth fluid medium 1.6ml, all the other are pipe 1ml often, get respectively and add in the first pipe by reagent diluent 0.4ml, 1ml is got to the 2nd pipe after mixing, dilute successively, the 10th pipe sucking-off 1ml discards, and the 11st pipe does not add medicinal liquid in contrast.Often pipe adds dilution bacterium liquid 0.1ml, cultivates 24h for 37 DEG C.Take out and observe bacterial growth situation.As drug liquid tube is muddy, namely represent bacterial growth, for reagent thing without bacteriostasis; As drug liquid tube is limpid, represent that bacterial growth is suppressed, the medicinal liquid of the greatest dilution of its energy bacteria growing inhibiting, is the minimal inhibitory concentration (MIC) of this medicine.By limpid medicinal liquid meat soup each pipe transferred species broth agar plates, cultivate 24h and observe, be still the bacteriocidal concentration of this medicine without the minimum drug level of bacterial growth.
Get sterilizing test tubes 11, the 1st pipe adds improvement Martin fluid medium 1.6ml, and all the other are pipe 1ml often, get respectively and add in the first pipe by reagent diluent 0.4ml, get 1ml after mixing to the 2nd pipe, dilute successively, 10th pipe sucking-off 1ml discards, and the 11st pipe does not add medicinal liquid in contrast.Often pipe adds dilution bacterium liquid 0.1ml, cultivates 24h for 35 DEG C, takes out and observe bacterial growth situation.As drug liquid tube is muddy, namely represent bacterial growth, for reagent thing without bacteriostasis; As drug liquid tube is limpid, represent that bacterial growth is suppressed, the medicinal liquid of the greatest dilution of its energy bacteria growing inhibiting, is the minimal inhibitory concentration (MIC) of this medicine.Limpid medicinal liquid meat soup each pipe transferred species sabouraud's agar is dull and stereotyped, cultivate 24h and observe, be still the bacteriocidal concentration of this medicine without the minimum drug level of bacterial growth.
(5) result: experimental result shows: the present invention is to reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210), Candida albicans all have stronger bacteriostasis, MIC is at 0.08g ~ 0.3g/g (by raw medicine calculation).In table 1.
Table 1 antibacterial activity in vitro of the present invention (n=2)
| Bacterial strain | Minimum inhibitory concentration (MIC) (g crude drug/g) |
| Staphylococcus aureus (standard) | 0.2 |
| Escherichia coli (standard) | 0.2 |
| Group B streptococcus (standard) | 0.08 |
| Candida albicans | 0.3 |
(6) conclusion: the present invention has good bacteriostasis, can be used for treating vaginitis.
Claims (4)
1. the colpitic Chinese medicine gel for the treatment of, it is characterized in that being extracted by following bulk drugs and adjuvant weight being prepared from: Herba Kalanchoes Laciniatae 18 parts, three is to 15 parts, joint, Herba Maianthemi Bifolii 12 parts, Herba Veronicae Ciliatae 15 parts, Caulis et Folium piperis 12 parts, Radix sidae acutae 15 parts, carbomer 1 part, propylene glycol 20 parts, ethanol 2 parts, azone 2 parts, triethanolamine 3 parts, distilled water 250 parts.
2. treat colpitic Chinese medicine gel as claimed in claim 1, it is characterized in that, preparation method comprises the steps:. get the mixing of above-mentioned Chinese medicine, decoct 2 times, add medical material weight 10 times of water gagings at every turn, each decoction 2 hours, filters, merging filtrate, when being evaporated to 70 DEG C, relative density is 1.1, add ethanol to the volume ratio of alcohol content and reach 75%, leave standstill 48 hours, filter, collect filtrate, decompression recycling ethanol, and filtrate is concentrated into 70 DEG C time, often rise volume concentrated solution containing the concentrated solution of crude drug amount 2kg, obtain Chinese medicine extraction concentrated solution; Getting carbomer, to add appropriate distilled water fully swelling, adds propylene glycol, ethanol, azone, use triethanolamine adjust ph, stir and get final product.
3. treat colpitic Chinese medicine gel as claimed in claim 1, it is characterized in that its pH value range is at 4.5-5.5.
4. treat the application of colpitic Chinese medicine gel in treatment colpitis medicine as claimed in claim 1.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177454A (en) * | 2016-07-18 | 2016-12-07 | 南京正宽医药科技有限公司 | One treats colpitic gel and preparation method thereof |
| CN108273123A (en) * | 2018-02-28 | 2018-07-13 | 苏州凌科特新材料有限公司 | A kind of medical hemostatic promoting healing aerogel dressing and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1413683A (en) * | 2002-11-13 | 2003-04-30 | 贵州和仁堂药业有限公司 | Medicine for treating gynecopathy |
| CN1489990A (en) * | 2003-09-12 | 2004-04-21 | 南京中医药大学 | Preparing method for superfine Chinese medicine jellies |
| CN102793881A (en) * | 2012-09-07 | 2012-11-28 | 南京市妇幼保健院 | Traditional Chinese medicine gel for treating vaginitis as well as preparation method and application of traditional Chinese medicine gel |
| CN103494958A (en) * | 2013-09-27 | 2014-01-08 | 周莉 | Traditional Chinese medicine lotion for treating gynecological inflammations as well as preparation method thereof |
-
2015
- 2015-05-19 CN CN201510257492.7A patent/CN104825744A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1413683A (en) * | 2002-11-13 | 2003-04-30 | 贵州和仁堂药业有限公司 | Medicine for treating gynecopathy |
| CN1489990A (en) * | 2003-09-12 | 2004-04-21 | 南京中医药大学 | Preparing method for superfine Chinese medicine jellies |
| CN102793881A (en) * | 2012-09-07 | 2012-11-28 | 南京市妇幼保健院 | Traditional Chinese medicine gel for treating vaginitis as well as preparation method and application of traditional Chinese medicine gel |
| CN103494958A (en) * | 2013-09-27 | 2014-01-08 | 周莉 | Traditional Chinese medicine lotion for treating gynecological inflammations as well as preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177454A (en) * | 2016-07-18 | 2016-12-07 | 南京正宽医药科技有限公司 | One treats colpitic gel and preparation method thereof |
| CN108273123A (en) * | 2018-02-28 | 2018-07-13 | 苏州凌科特新材料有限公司 | A kind of medical hemostatic promoting healing aerogel dressing and preparation method thereof |
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Application publication date: 20150812 |