CN108273123A - A kind of medical hemostatic promoting healing aerogel dressing and preparation method thereof - Google Patents
A kind of medical hemostatic promoting healing aerogel dressing and preparation method thereof Download PDFInfo
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- CN108273123A CN108273123A CN201810166770.1A CN201810166770A CN108273123A CN 108273123 A CN108273123 A CN 108273123A CN 201810166770 A CN201810166770 A CN 201810166770A CN 108273123 A CN108273123 A CN 108273123A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0042—Fibrin; Fibrinogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The present invention provides a kind of medical hemostatic promoting healing aerogel dressings and preparation method thereof.Preparation method is as follows：（1）Prepare Japanese apricot extract, two leaves dance extract, Japan's Parathelypteris nipponica extract；（2）Prepare Euphorbia stracheyi Boiss extract, polished bard harelip flower extract；（3）Polyvinyl alcohol, hyaluronic acid are put into medical distilled water solution, is stirred at 90 DEG C, forms uniform solution；（4）60 DEG C are cooled to, Quaternary Ammonium Salt of Chitosan, Fibrin Glue, calcium chloride are then added in mass ratio, rotating speed is kept, continues to stir；（5）Step is added（1）、（2）Extract obtained, glycerine are modulated into the solution of suitable viscosity, and sterilizing preserves 12 for 24 hours at 4 DEG C, you can.The medical hemostatic promoting healing aerogel dressing of the present invention can quick-acting haemostatic powder, while dressing also has the function of rapidly promoting wound healing.
Description
Technical field
The present invention relates to field of medical materials, and in particular to a kind of medical hemostatic promoting healing aerogel dressing and its preparation side
Method.
Background technology
Hydrogel medical dressing has good hydrophily, can absorb the diffusate of wound, and not with wound adhesion, because
Newborn granulation or epithelial tissue will not be destroyed when this dressing.When application, aerogel dressing is pasted onto the skin of patient by doctor
On surface, then it is fixed on wound with adhesive plaster or polyurethane film again.When replacement, as long as hydrogel is lightly taken off
Fall, or is fallen with normal saline flushing.Influence very little of the replacement process to the surface of a wound, this be various hospital gauzes it is incomparable.
Compared with other common dressing, hydrogel will not fall off the impurity such as fiber on wound.It, can in wound healing
Easily hydrogel is washed from wound.In the wound that some have skin histology loss, such as skin-grafting, scratch, burning
Wound etc. is suitble to use sheet-like hydrous gel.On these wounds, hydrogel sheet protects wound, avoids the dehydration and drying of wound.This
Be also hydrogel great advantage-it can be generated on wound one moisten environment, promote the slough on wound by enzyme
It decomposes, thus a good environment is created for the healing of wound.Ideal medical dressing should have following characteristic：It can inhale
The exudate of receipts keeps surface of a wound cleaning；Contact surface can keep certain humidity, and have good air permeability effect, accelerate the surface of a wound
Healing；It can effectively obstruct and kill harmful microorganism；It is not easy to stick together with wound when removing dressing.It puts into production and faces at present
The dressing generally existing haemostatic effect that uses of bed is undesirable, and poor using the healing effect of rear skin, therefore still up for into one
Step improves and improves its haemostatic effect and promotes wound healing or myogenic.
Invention content
Technical problems to be solved：The object of the present invention is to provide a kind of medical hemostatic promoting healing aerogel dressing, hemostasis
Effect is good, greatly improves the bleeding stopping period of wound, while promoting wound healing.
Technical solution：A kind of medical hemostatic promoting healing aerogel dressing is prepared by weight by following component：Poly- second
3-8 parts of enol 2-4g, hyaluronic acid, 3-10 parts of Fibrin Glue, 2-5 parts of calcium chloride, 3-10 parts of glycerine, Quaternary Ammonium Salt of Chitosan
3-6 parts, 20-40 parts of medical distilled water, 1.5-2.5 parts of Japanese apricot extract, 0.8-1.8 parts of twoleaf beadruby herb extract, Japan gold
2-3 parts of star fern extract, 0.8-1.5 parts of Euphorbia stracheyi Boiss extract, 0.5-1.2 parts of polished bard harelip flower extract.
It is further preferred that a kind of medical hemostatic promoting healing aerogel dressing, is made by weight by following component
It is standby to form：4-7 parts of polyvinyl alcohol 2.5-3.5g, hyaluronic acid, 5-8 parts of Fibrin Glue, 3-4 parts of calcium chloride, glycerine 5-8
Part, 4-5 parts of Quaternary Ammonium Salt of Chitosan, 25-35 parts of medical distilled water, 1.8-2.2 parts of Japanese apricot extract, twoleaf beadruby herb extract
1.2-1.6 parts, 2.2-2.6 parts of Japan's Parathelypteris nipponica extract, 1-1.4 parts of Euphorbia stracheyi Boiss extract, polished bard harelip flower extract
0.7-1 parts.
The preparation method of above-mentioned medical hemostatic promoting healing aerogel dressing, includes the following steps：
（1）It takes Japanese apricot, twoleaf beadruby herb, Japan Parathelypteris nipponica to crush, extracts 2-4h, solid-liquid ratio 1 with 65% alcohol at normal temperature respectively:
2-1:4, it is extracted with ethyl acetate, after extract is separately added into ether dissolution, adds distilled water and distilled, collection distillates
Liquid is dehydrated with anhydrous sodium sulfate, and Japanese apricot extract, two leaves dance extract, Japan's Parathelypteris nipponica extract are made respectively；
（2）It takes Euphorbia stracheyi Boiss, polished bard lagochilline to crush, respectively with the distilled water of 5 times of parts by weight, impregnates for 24 hours, be subsequently placed in 60-
2h is heated in 80 DEG C of water-baths, filters to isolate filtrate, adds the distilled water of 5 times of parts by weight, heating and filtering, merging is filtered twice
Liquid, it is 1.25 to be concentrated into relative density respectively；
（3）Polyvinyl alcohol, hyaluronic acid are put into medical distilled water solution, 60-180min, rotating speed 60- are stirred at 90 DEG C
120r/min forms uniform solution；
（4）60 DEG C are cooled to, Quaternary Ammonium Salt of Chitosan, Fibrin Glue, calcium chloride are then added in mass ratio, keeps rotating speed, after
Continuous stirring 60min；
（5）Step is added（1）、（2）Extract obtained, glycerine are modulated into the solution of suitable viscosity, and sterilizing is protected at 4 DEG C
Deposit 12-24h, you can.
Further, the preparation method of a kind of medical hemostatic promoting healing aerogel dressing, the step（1）In carry
It is 2.5-3.5h, solid-liquid ratio 1 to take the time:3.
Further, the preparation method of a kind of medical hemostatic promoting healing aerogel dressing, the step（2）Middle water
Bath temperature is 65-75 DEG C.
Further, the preparation method of a kind of medical hemostatic promoting healing aerogel dressing, the step（3）In stir
It is 120min, rotating speed 90r/min to mix the time.
Further, the preparation method of a kind of medical hemostatic promoting healing aerogel dressing, the step（5）It goes out
Bacterium processing is sterilized using Co-60 gamma-ray irradiations, sterilizing dose 40-80kGy.
Further, the preparation method of a kind of medical hemostatic promoting healing aerogel dressing, the step（5）In
Holding time is 15-20h.
Advantageous effect：The medical hemostatic promoting healing aerogel dressing of the present invention has good haemostatic effect, to a rabbit left side
Ear auricular vein bleeding stopping period only needs 4s, auris dextra ear edge artery hemostasis time only to need 7 seconds, and the left and right hind leg femoral hemostasis time is only
13s is needed, can realize hemostasis within a short period of time, is suitable for the emergent management of acute bleeding；Euphorbia stracheyi Boiss, polished bard rabbit is added simultaneously
The healing rate of wound is significantly improved after the extract of lip flower.
Specific implementation mode
Embodiment 1
A kind of medical hemostatic promoting healing aerogel dressing is prepared by weight by following component：Polyvinyl alcohol 2g, hyalomitome
3 parts of acid, 10 parts of Fibrin Glue, 5 parts of calcium chloride, 3 parts of glycerine, 6 parts of Quaternary Ammonium Salt of Chitosan, 20 parts of medical distilled water, Japanese apricot
1.5 parts of extract, 0.8 part of twoleaf beadruby herb extract, 3 parts of Japan's Parathelypteris nipponica extract, 0.8 part of Euphorbia stracheyi Boiss extract, light
Pierce 0.5 part of harelip flower extract.
The preparation method of above-mentioned medical hemostatic promoting healing aerogel dressing is：（1）Take Japanese apricot, twoleaf beadruby herb, Japan's gold
Star fern crushes, and extracts 4h, solid-liquid ratio 1 with 65% alcohol at normal temperature respectively:4, it is extracted with ethyl acetate, extract is separately added into second
After ether dissolving, add distilled water and distilled, collect distillate, be dehydrated with anhydrous sodium sulfate, be made respectively Japanese apricot extract,
Two leaves wave extract, Japan's Parathelypteris nipponica extract；（2）Euphorbia stracheyi Boiss, polished bard lagochilline is taken to crush, respectively with 5 times of parts by weight
Distilled water impregnates for 24 hours, is subsequently placed in 60 DEG C of water-baths and heats 2h, filter to isolate filtrate, add the distillation of 5 times of parts by weight
Water, heating and filtering merge filtrate twice, and it is 1.25 to be concentrated into relative density respectively；（3）By polyvinyl alcohol, hyaluronic acid
Medical distilled water solution is put into, 60min, rotating speed 120r/min are stirred at 90 DEG C, forms uniform solution；（4）60 DEG C are cooled to,
Then Quaternary Ammonium Salt of Chitosan, Fibrin Glue, calcium chloride are added in mass ratio, keeps rotating speed, continues to stir 60min；（5）It is added
Step（1）、（2）Extract obtained, glycerine are modulated into the solution of suitable viscosity, and sterilizing preserves 12h at 4 DEG C, you can.
Embodiment 2
A kind of medical hemostatic promoting healing aerogel dressing is prepared by weight by following component：Polyvinyl alcohol 4g, hyalomitome
8 parts of acid, 3 parts of Fibrin Glue, 2 parts of calcium chloride, 10 parts of glycerine, 3 parts of Quaternary Ammonium Salt of Chitosan, 40 parts of medical distilled water, Japanese apricot
2.5 parts of extract, 1.8 parts of twoleaf beadruby herb extract, 2 parts of Japan's Parathelypteris nipponica extract, 1.5 parts of Euphorbia stracheyi Boiss extract, light
Pierce 1.2 parts of harelip flower extract.
The preparation method of above-mentioned medical hemostatic promoting healing aerogel dressing is：（1）Take Japanese apricot, twoleaf beadruby herb, Japan's gold
Star fern crushes, and extracts 2h, solid-liquid ratio 1 with 65% alcohol at normal temperature respectively:2, it is extracted with ethyl acetate, extract is separately added into second
After ether dissolving, add distilled water and distilled, collect distillate, be dehydrated with anhydrous sodium sulfate, be made respectively Japanese apricot extract,
Two leaves wave extract, Japan's Parathelypteris nipponica extract；（2）Euphorbia stracheyi Boiss, polished bard lagochilline is taken to crush, respectively with 5 times of parts by weight
Distilled water impregnates for 24 hours, is subsequently placed in 80 DEG C of water-baths and heats 2h, filter to isolate filtrate, add the distillation of 5 times of parts by weight
Water, heating and filtering merge filtrate twice, and it is 1.25 to be concentrated into relative density respectively；（3）By polyvinyl alcohol, hyaluronic acid
Medical distilled water solution is put into, 180min, rotating speed 60r/min are stirred at 90 DEG C, forms uniform solution；（4）60 DEG C are cooled to,
Then Quaternary Ammonium Salt of Chitosan, Fibrin Glue, calcium chloride are added in mass ratio, keeps rotating speed, continues to stir 60min；（5）It is added
Step（1）、（2）Extract obtained, glycerine are modulated into the solution of suitable viscosity, and sterilizing preserves for 24 hours at 4 DEG C, you can.
Embodiment 3
A kind of medical hemostatic promoting healing aerogel dressing is prepared by weight by following component：It is polyvinyl alcohol 2.5g, transparent
4 parts of matter acid, 8 parts of Fibrin Glue, 4 parts of calcium chloride, 8 parts of glycerine, 5 parts of Quaternary Ammonium Salt of Chitosan, 25 parts of medical distilled water, Japanese apricot
1.8 parts of extract, 1.6 parts of twoleaf beadruby herb extract, 2.2 parts of Japan's Parathelypteris nipponica extract, 1 part of Euphorbia stracheyi Boiss extract, light
Pierce 1 part of harelip flower extract.
The preparation method of above-mentioned medical hemostatic promoting healing aerogel dressing is：（1）Take Japanese apricot, twoleaf beadruby herb, Japan's gold
Star fern crushes, and extracts 2.5h, solid-liquid ratio 1 with 65% alcohol at normal temperature respectively:3, it is extracted with ethyl acetate, extract is separately added into
It after ether dissolution, adds distilled water and is distilled, collect distillate, be dehydrated with anhydrous sodium sulfate, Japanese apricot extraction is made respectively
Object, two leaves dance extract, Japan's Parathelypteris nipponica extract；（2）Euphorbia stracheyi Boiss, polished bard lagochilline is taken to crush, respectively with 5 times of parts by weight
Distilled water, impregnate for 24 hours, be subsequently placed in 75 DEG C of water-baths and heat 2h, filter to isolate filtrate, add the steaming of 5 times of parts by weight
Distilled water, heating and filtering merge filtrate twice, and it is 1.25 to be concentrated into relative density respectively；（3）By polyvinyl alcohol, hyalomitome
Acid puts into medical distilled water solution, and 120min, rotating speed 90r/min are stirred at 90 DEG C, forms uniform solution；（4）It is cooled to 60
DEG C, Quaternary Ammonium Salt of Chitosan, Fibrin Glue, calcium chloride are then added in mass ratio, keeps rotating speed, continues to stir 60min；（5）
Step is added（1）、（2）Extract obtained, glycerine are modulated into the solution of suitable viscosity, and sterilizing preserves 15h, i.e., at 4 DEG C
It can.
Embodiment 4
A kind of medical hemostatic promoting healing aerogel dressing is prepared by weight by following component：It is polyvinyl alcohol 3.5g, transparent
7 parts of matter acid, 5 parts of Fibrin Glue, 3 parts of calcium chloride, 5 parts of glycerine, 4 parts of Quaternary Ammonium Salt of Chitosan, 35 parts of medical distilled water, Japanese apricot
2.2 parts of extract, 1.2 parts of twoleaf beadruby herb extract, 2.6 parts of Japan's Parathelypteris nipponica extract, 1.4 parts of Euphorbia stracheyi Boiss extract,
0.7 part of polished bard harelip flower extract.
The preparation method of above-mentioned medical hemostatic promoting healing aerogel dressing is：（1）Take Japanese apricot, twoleaf beadruby herb, Japan's gold
Star fern crushes, and extracts 3.5h, solid-liquid ratio 1 with 65% alcohol at normal temperature respectively:3, it is extracted with ethyl acetate, extract is separately added into
It after ether dissolution, adds distilled water and is distilled, collect distillate, be dehydrated with anhydrous sodium sulfate, Japanese apricot extraction is made respectively
Object, two leaves dance extract, Japan's Parathelypteris nipponica extract；（2）Euphorbia stracheyi Boiss, polished bard lagochilline is taken to crush, respectively with 5 times of parts by weight
Distilled water, impregnate for 24 hours, be subsequently placed in 65 DEG C of water-baths and heat 2h, filter to isolate filtrate, add the steaming of 5 times of parts by weight
Distilled water, heating and filtering merge filtrate twice, and it is 1.25 to be concentrated into relative density respectively；（3）By polyvinyl alcohol, hyalomitome
Acid puts into medical distilled water solution, and 120min, rotating speed 90r/min are stirred at 90 DEG C, forms uniform solution；（4）It is cooled to 60
DEG C, Quaternary Ammonium Salt of Chitosan, Fibrin Glue, calcium chloride are then added in mass ratio, keeps rotating speed, continues to stir 60min；（5）
Step is added（1）、（2）Extract obtained, glycerine are modulated into the solution of suitable viscosity, and sterilizing preserves 20h, i.e., at 4 DEG C
It can.
Embodiment 5
A kind of medical hemostatic promoting healing aerogel dressing is prepared by weight by following component：Polyvinyl alcohol 3g, hyalomitome
Acid 6 parts, 5.5 parts of Fibrin Glue, 3.5 parts of calcium chloride, 6.5 parts of glycerine, 4 parts of Quaternary Ammonium Salt of Chitosan, 30 parts of medical distilled water,
2 parts of Japanese apricot extract, 1.4 parts of twoleaf beadruby herb extract, 2.4 parts of Japan's Parathelypteris nipponica extract, Euphorbia stracheyi Boiss extract 1.2
Part, 0.8 part of polished bard harelip flower extract.
The preparation method of above-mentioned medical hemostatic promoting healing aerogel dressing is：（1）Take Japanese apricot, twoleaf beadruby herb, Japan's gold
Star fern crushes, and extracts 3h, solid-liquid ratio 1 with 65% alcohol at normal temperature respectively:3, it is extracted with ethyl acetate, extract is separately added into second
After ether dissolving, add distilled water and distilled, collect distillate, be dehydrated with anhydrous sodium sulfate, be made respectively Japanese apricot extract,
Two leaves wave extract, Japan's Parathelypteris nipponica extract；（2）Euphorbia stracheyi Boiss, polished bard lagochilline is taken to crush, respectively with 5 times of parts by weight
Distilled water impregnates for 24 hours, is subsequently placed in 70 DEG C of water-baths and heats 2h, filter to isolate filtrate, add the distillation of 5 times of parts by weight
Water, heating and filtering merge filtrate twice, and it is 1.25 to be concentrated into relative density respectively；（3）By polyvinyl alcohol, hyaluronic acid
Medical distilled water solution is put into, 120min, rotating speed 90r/min are stirred at 90 DEG C, forms uniform solution；（4）60 DEG C are cooled to,
Then Quaternary Ammonium Salt of Chitosan, Fibrin Glue, calcium chloride are added in mass ratio, keeps rotating speed, continues to stir 60min；（5）It is added
Step（1）、（2）Extract obtained, glycerine are modulated into the solution of suitable viscosity, and sterilizing preserves 18h at 4 DEG C, you can.
Comparative example 1
A kind of medical hemostatic promoting healing aerogel dressing is prepared by weight by following component：Polyvinyl alcohol 2g, hyalomitome
3 parts of acid, 10 parts of Fibrin Glue, 5 parts of calcium chloride, 3 parts of glycerine, 6 parts of Quaternary Ammonium Salt of Chitosan, 20 parts of medical distilled water, high mountain
0.8 part of root of Beijing euphorbia extract, 0.5 part of polished bard harelip flower extract.
The preparation method of above-mentioned medical hemostatic promoting healing aerogel dressing is：（1）Take Euphorbia stracheyi Boiss, polished bard harelip pollen
It is broken, respectively with the distilled water of 5 times of parts by weight, impregnates for 24 hours, be subsequently placed in 60 DEG C of water-baths and heat 2h, filter to isolate filtrate, then
The distilled water of 5 times of parts by weight is added, heating and filtering merges filtrate twice, and it is 1.25 to be concentrated into relative density respectively；（2）
Polyvinyl alcohol, hyaluronic acid are put into medical distilled water solution, 60min, rotating speed 120r/min are stirred at 90 DEG C, is formed uniform
Solution；（3）60 DEG C are cooled to, Quaternary Ammonium Salt of Chitosan, Fibrin Glue, calcium chloride are then added in mass ratio, keeps rotating speed, after
Continuous stirring 60min；（4）Step is added（1）Extract obtained, glycerine are modulated into the solution of suitable viscosity, sterilizing, at 4 DEG C
Lower preservation 12h, you can.
Comparative example 2
A kind of medical hemostatic promoting healing aerogel dressing is prepared by weight by following component：Polyvinyl alcohol 4g, hyalomitome
8 parts of acid, 3 parts of Fibrin Glue, 2 parts of calcium chloride, 10 parts of glycerine, 3 parts of Quaternary Ammonium Salt of Chitosan, 40 parts of medical distilled water, Japanese apricot
2.5 parts of extract, 1.8 parts of twoleaf beadruby herb extract, 2 parts of Japan's Parathelypteris nipponica extract.
The preparation method of above-mentioned medical hemostatic promoting healing aerogel dressing is：（1）Take Japanese apricot, twoleaf beadruby herb, Japan's gold
Star fern crushes, and extracts 2h, solid-liquid ratio 1 with 65% alcohol at normal temperature respectively:2, it is extracted with ethyl acetate, extract is separately added into second
After ether dissolving, add distilled water and distilled, collect distillate, be dehydrated with anhydrous sodium sulfate, be made respectively Japanese apricot extract,
Two leaves wave extract, Japan's Parathelypteris nipponica extract；（2）Polyvinyl alcohol, hyaluronic acid are put into medical distilled water solution, at 90 DEG C
180min, rotating speed 60r/min are stirred, uniform solution is formed；（3）60 DEG C are cooled to, quaternary ammonium salt crust is then added in mass ratio
Glycan, Fibrin Glue, calcium chloride keep rotating speed, continue to stir 60min；（4）Step is added（1）Extract obtained, the third three
Alcohol is modulated into the solution of suitable viscosity, and sterilizing preserves for 24 hours at 4 DEG C, you can.
The property indices of material of the present invention see the table below, it may be seen that this medical hemostatic promoting healing aerogel dressing
With good haemostatic effect, 4s, auris dextra ear edge artery hemostasis time is only needed only to need 7 the left ear auricular vein bleeding stopping period of rabbit
Second, the left and right hind leg femoral hemostasis time only needs 13s, can realize hemostasis within a short period of time, is suitable for the urgent of acute bleeding
Processing；Be added simultaneously Euphorbia stracheyi Boiss, polished bard lagochilline extract after the healing rate of embodiment be apparently higher than the healing of comparative example
Rate, both extracts may advantageously facilitate the healing of wound.
The property indices of 1 medical hemostatic promoting healing aerogel dressing of table
Hemostasis experiment：140 Japan large ear rabbits are chosen, are divided into 7 groups, every rabbit cuts off left ear auricular vein（A）, auris dextra
Ear edge artery（B）And 2/3rds of left hind femoral artery（C）, respectively by embodiment and comparison after free bleeding 5s, 5s
The aerogel dressing pressure dressing wound of example gained.Wherein, each group experiment dressing used uniformly cuts into length × width × height=5cm
The cuboid of × 5cm × 2cm is blocky.
Wound healing is tested：Experimental animal uses SD rats, chooses 70 rats, is divided into 7 groups of points of observation, respectively
3 after wound, 8,15,21 days.Rat back is lost hair or feathers with 4% vulcanized sodium liquid, is anaesthetized afterwards for 24 hours, is then scalded and is caused within 15 seconds greatly with 80 DEG C of water-baths
10% depth II degree skin scalds of mouse back give 5mL physiological saline after wound through abdominal cavity.It respectively will be obtained by embodiment and comparative example
Aerogel dressing flap coverage, observing time point calculate Wound healing rate：
Wound healing rate=(original surface of a wound area-do not heal surface of a wound area)/original surface of a wound area.
Claims (8)
1. a kind of medical hemostatic promoting healing aerogel dressing, which is characterized in that be prepared by weight by following component：Poly- second
3-8 parts of enol 2-4g, hyaluronic acid, 3-10 parts of Fibrin Glue, 2-5 parts of calcium chloride, 3-10 parts of glycerine, Quaternary Ammonium Salt of Chitosan
3-6 parts, 20-40 parts of medical distilled water, 1.5-2.5 parts of Japanese apricot extract, 0.8-1.8 parts of twoleaf beadruby herb extract, Japan gold
2-3 parts of star fern extract, 0.8-1.5 parts of Euphorbia stracheyi Boiss extract, 0.5-1.2 parts of polished bard harelip flower extract.
2. a kind of medical hemostatic promoting healing aerogel dressing according to claim 1, which is characterized in that pressed by following component
Parts by weight are prepared：4-7 parts of polyvinyl alcohol 2.5-3.5g, hyaluronic acid, 5-8 parts of Fibrin Glue, 3-4 parts of calcium chloride, third
5-8 parts of triol, 4-5 parts of Quaternary Ammonium Salt of Chitosan, 25-35 parts of medical distilled water, 1.8-2.2 parts of Japanese apricot extract, twoleaf beadruby herb
1.2-1.6 parts of extract, 2.2-2.6 parts of Japan's Parathelypteris nipponica extract, 1-1.4 parts of Euphorbia stracheyi Boiss extract, polished bard lagochilline carry
Take 0.7-1 parts of object.
3. a kind of preparation method of medical hemostatic promoting healing aerogel dressing, which is characterized in that include the following steps：
（1）It takes Japanese apricot, twoleaf beadruby herb, Japan Parathelypteris nipponica to crush, extracts 2-4h, solid-liquid ratio 1 with 65% alcohol at normal temperature respectively:
2-1:4, it is extracted with ethyl acetate, after extract is separately added into ether dissolution, adds distilled water and distilled, collection distillates
Liquid is dehydrated with anhydrous sodium sulfate, and Japanese apricot extract, two leaves dance extract, Japan's Parathelypteris nipponica extract are made respectively；
（2）It takes Euphorbia stracheyi Boiss, polished bard lagochilline to crush, respectively with the distilled water of 5 times of parts by weight, impregnates for 24 hours, be subsequently placed in 60-
2h is heated in 80 DEG C of water-baths, filters to isolate filtrate, adds the distilled water of 5 times of parts by weight, heating and filtering, merging is filtered twice
Liquid, it is 1.25 to be concentrated into relative density respectively；
（3）Polyvinyl alcohol, hyaluronic acid are put into medical distilled water solution, 60-180min, rotating speed 60- are stirred at 90 DEG C
120r/min forms uniform solution；
（4）60 DEG C are cooled to, Quaternary Ammonium Salt of Chitosan, Fibrin Glue, calcium chloride are then added in mass ratio, keeps rotating speed, after
Continuous stirring 60min；
（5）Step is added（1）、（2）Extract obtained, glycerine are modulated into the solution of suitable viscosity, and sterilizing is protected at 4 DEG C
Deposit 12-24h, you can.
4. a kind of preparation method of medical hemostatic promoting healing aerogel dressing according to claim 3, it is characterised in that：Institute
State step（1）Middle extraction time is 2.5-3.5h, solid-liquid ratio 1:3.
5. a kind of preparation method of medical hemostatic promoting healing aerogel dressing according to claim 3, it is characterised in that：Institute
State step（2）Middle bath temperature is 65-75 DEG C.
6. a kind of preparation method of medical hemostatic promoting healing aerogel dressing according to claim 3, it is characterised in that：Institute
State step（3）Middle mixing time is 120min, rotating speed 90r/min.
7. a kind of preparation method of medical hemostatic promoting healing aerogel dressing according to claim 3, it is characterised in that：Institute
The step of stating（5）Sterilization treatment is sterilized using Co-60 gamma-ray irradiations, sterilizing dose 40-80kGy.
8. a kind of preparation method of medical hemostatic promoting healing aerogel dressing according to claim 3, it is characterised in that：Institute
The step of stating（5）Holding time is 15-20h.
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| CN109568157A (en) * | 2018-12-18 | 2019-04-05 | 东元科技有限公司 | A kind of external used isolation gel aerosol solution |
| CN110974778A (en) * | 2019-05-14 | 2020-04-10 | 暨南大学 | High-drug-loading-rate slow-release microgel ointment and preparation method and application thereof |
| CN114989621A (en) * | 2022-07-07 | 2022-09-02 | 宁波泉水生物科技有限公司 | Application of modified hyaluronic acid in medical and American injection filling reagent |
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| CN110974778B (en) * | 2019-05-14 | 2021-06-11 | 暨南大学 | High-drug-loading-rate slow-release microgel ointment and preparation method and application thereof |
| CN114989621A (en) * | 2022-07-07 | 2022-09-02 | 宁波泉水生物科技有限公司 | Application of modified hyaluronic acid in medical and American injection filling reagent |
| CN114989621B (en) * | 2022-07-07 | 2022-12-20 | 山东卓东生物科技有限公司 | Application of modified hyaluronic acid in injection filling reagent for medical and cosmetic treatment |
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