CN103655361B - Traditional Chinese medicinal hand lotion - Google Patents

Traditional Chinese medicinal hand lotion Download PDF

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Publication number
CN103655361B
CN103655361B CN201310704635.5A CN201310704635A CN103655361B CN 103655361 B CN103655361 B CN 103655361B CN 201310704635 A CN201310704635 A CN 201310704635A CN 103655361 B CN103655361 B CN 103655361B
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traditional chinese
chinese medicinal
parts
hand lotion
medicinal hand
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CN103655361A (en
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李强
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GUANGDONG YIMING PHARMACEUTICAL CO Ltd
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QINGDAO QINCHENG MEDICINE TECHNOLOGY Co Ltd
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Abstract

The invention provides traditional Chinese medicinal hand lotion. The traditional Chinese medicinal hand lotion comprises the following components: 40-60 parts of sodium ethoxylated alkyl sulfate, 6-10 parts of sodium alkyl benzene sulfonate, 1-2 parts of coconut oil fatty acid diethanolamide, 2-3 parts of glycerinum, 2-4 parts of littlefruit heartseed fruit and 2-4 parts of tali lobelia. The traditional Chinese medicinal hand lotion is prepared by a corresponding preparation method and has a good antibacterial effect.

Description

A kind of Traditional Chinese medicinal hand lotion
Technical field
The present invention relates to cosmetic technical field, be specifically related to a kind of Traditional Chinese medicinal hand lotion.
Background technology
The main function of handwashing liquid plays the effect of clean skin protection, and some specific composition can play the effect of sterilization, sterilization, and such as escherichia coli etc. are along with the living standard of people improves day by day, also more and more higher to the prescription of handwashing liquid.Although the handwashing liquid that market is sold is various, a lot of product with the addition of some harmful materials more or less: as bleaching powder, hydrargyrum, cleaning agent, caustic etc.People there is also a desire for more excellent handwashing liquid, particularly utilize Chinese medicine to prepare handwashing liquid.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of handwashing liquid and preparation method thereof.
Technical scheme: the object of the invention is by following scheme realize:
A kind of Traditional Chinese medicinal hand lotion, is made up of Sodium Alcohol Ether Sulphate 40-60 part, sodium alkyl benzene sulfonate 6-10 part, cocoanut fatty acid diethanolamide 1-2 part, glycerol 2-3 part, Fructus Cardiospermi microcarpi 2-4 part, Herba Lobeliae taliensis 2-4 part.
Above-mentioned Traditional Chinese medicinal hand lotion, preparation process is: get Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis, decoct with water twice, and first time adds water as the 8-12 times amount of medical material weight, decoct 1-2h, second time adds water as the 6-10 times amount of medical material weight, decocts 1-2h collecting decoction, is concentrated into 10 times amount of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis gross weight, add Sodium Alcohol Ether Sulphate, sodium alkyl benzene sulfonate, cocoanut fatty acid diethanolamide, glycerol, about 70-80 DEG C melt and dissolved, to obtain final product.
The application of above-mentioned Traditional Chinese medicinal hand lotion in preparation Traditional Chinese medicinal hand lotion.
Beneficial effect:
In the present invention, Fructus Cardiospermi microcarpi nourishes blood dampness removing and Herba Lobeliae taliensis heat-clearing and toxic substances removing, both compatibilities, and fungistatic effect is good, and here is that the present invention affects result of the test to staphylococcus aureus.
1 test material
(1) medicine and reagent
By reagent: prepare Traditional Chinese medicinal hand lotion by preparation embodiment 3 method, be the present invention: specification: 2g crude drug/g, lot number: 20120503; And according to the method for embodiment 3, remove the handwashing liquid of Fructus Cardiospermi microcarpi preparation only containing Herba Lobeliae taliensis, remove the handwashing liquid of Herba Lobeliae taliensis only containing Fructus Cardiospermi microcarpi; Sodium chloride: Shanghai hundred million chemical reagent company limiteies of a specified duration, lot number: 00060120.Nutrient broth medium: CAS Shanghai Insect Bio Technological Development Co., Ltd., lot number: 110516.Nutrient agar: microorganism reagent factory of Jiangsu Prov. Disease Preventing and Controlling Center, lot number: 110016.Improvement Martin culture medium: sky, Hangzhou and microorganism reagent company limited, lot number: 100831.Improvement Martin culture medium: Beijing three medicine scientific and technological development company, lot number: 111213; Sabouraud's agar: Beijing Luqiao Technology Co., Ltd. of China Inst. of Quarantine Inspection Sciences, lot number: 1007153; Calf serum, Hangzhou Sijiqing Biological Engineering Material Co., Ltd., lot number: 100508; De-fine Sheep Blood, purchased from Jiangning county epidemic prevention station, lot number: 120312
(2) bacterial strain
Reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210) are provided by Disease epizootic prevention center microorganism reagent factory of Jiangsu Province; Candida albicans (98100) is provided by institute for drug control, Jiangsu Province.
(3) instrument and equipment
Electronic balance, Beijing Sai Duolisi balance company limited produces; Full-automatic high-pressure autoclave, Japanese SANYO;
Superclean bench, Suzhou Decontamination Equipment Plant; SHP-80 biochemical cultivation case, Shanghai is gloomy reliablely tests Instrument Ltd.
2 experimental techniques
(1) antibacterial culturing
Get reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210) bacterial strain a little, are inoculated in nutrient broth medium respectively, cultivate 18h for 37 DEG C.(adding 20% calf serum in group B streptococcus broth bouillon) gets each bacterial strain nutrient broth culture that 18h cultivates, and does 10-3 dilution for experiment with nutrient broth.Extracting waste candidiasis bacterial strain is a little, is inoculated in improvement Martin culture medium, cultivates 24h for 35 DEG C.Get the Candida albicans culture that 24h cultivates, be used for experiment with improvement Martin culture medium 10-3 dilution.
(2) doubling dilution (test tube method)
Get sterilizing test tubes 11, the 1st pipe adds nutrient broth fluid medium 1.6ml, and all the other are pipe 1ml often, get respectively and add in the first pipe by reagent diluent 0.4ml, get 1ml after mixing to the 2nd pipe, dilute successively, 10th pipe sucking-off 1ml discards, and the 11st pipe does not add medicinal liquid in contrast.Often pipe adds dilution bacterium liquid 0.1ml, cultivates 24h for 37 DEG C.Take out and observe bacterial growth situation.As drug liquid tube is muddy, namely represent bacterial growth, for reagent thing without bacteriostasis; As drug liquid tube is limpid, represent that bacterial growth is suppressed, the medicinal liquid of the greatest dilution of its energy bacteria growing inhibiting, is the minimal inhibitory concentration (MIC) of this medicine.By limpid medicinal liquid meat soup each pipe transferred species broth agar plates, cultivate 24h and observe, be still the bacteriocidal concentration of this medicine without the minimum drug level of bacterial growth.
Get sterilizing test tubes 11, the 1st pipe adds improvement Martin fluid medium 1.6ml, and all the other are pipe 1ml often, get respectively and add in the first pipe by reagent diluent 0.4ml, get 1ml after mixing to the 2nd pipe, dilute successively, 10th pipe sucking-off 1ml discards, and the 11st pipe does not add medicinal liquid in contrast.Often pipe adds dilution bacterium liquid 0.1ml, cultivates 24h for 35 DEG C, takes out and observe bacterial growth situation.As drug liquid tube is muddy, namely represent bacterial growth, for reagent thing without bacteriostasis; As drug liquid tube is limpid, represent that bacterial growth is suppressed, the medicinal liquid of the greatest dilution of its energy bacteria growing inhibiting, is the minimal inhibitory concentration (MIC) of this medicine.Limpid medicinal liquid meat soup each pipe transferred species sabouraud's agar is dull and stereotyped, cultivate 24h and observe, be still the bacteriocidal concentration of this medicine without the minimum drug level of bacterial growth.
3 results
Experimental result shows: Traditional Chinese medicinal hand lotion of the present invention is to reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210), Candida albicans all have stronger bacteriostasis, and MIC presses raw medicine calculation at 0.05g ~ 0.2g/g().In table 1.
Table 1 antibacterial activity in vitro of the present invention (n=2) unit: minimum inhibitory concentration (MIC) (g crude drug/g)
Bacterial strain The present invention Handwashing liquid only containing Herba Lobeliae taliensis Handwashing liquid only containing Fructus Cardiospermi microcarpi
Staphylococcus aureus (standard) 0.3**# 0.1 0.1
Escherichia coli (standard) 0.4*## 0.05 0.1
Group B streptococcus (standard) 0.3*# 0.05 0.05
Candida albicans 0.5**# 0.1 0.05
Legend: compare * P<0.05 with the Plant liquid soap only containing Herba Lobeliae taliensis; * p<0.01, compares #P<0.05 with the Plant liquid soap only containing Fructus Cardiospermi microcarpi; ##p<0.013.1.4 conclusion
Traditional Chinese medicinal hand lotion of the present invention has good bacteriostasis, and with the handwashing liquid only containing Herba Lobeliae taliensis or the handwashing liquid only containing Fructus Cardiospermi microcarpi, there is significant difference.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1
Get each 2 parts of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis, decoct with water twice, first time adds water as 8 times amount of medical material weight, decocts 1h, and second time adds water as 6 times amount of medical material weight, decoct 1h collecting decoction, be concentrated into 10 times amount of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis gross weight, add Sodium Alcohol Ether Sulphate 40 parts, sodium alkyl benzene sulfonate 6 parts, cocoanut fatty acid diethanolamide 1 part, glycerol 2 parts, about 70-80 DEG C melt and dissolved, to obtain final product.
Embodiment 2
Get each 4 parts of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis, decoct with water twice, first time adds water as 12 times amount of medical material weight, decocts 2h, and second time adds water as 10 times amount of medical material weight, decoct 2h collecting decoction, be concentrated into 10 times amount of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis gross weight, add Sodium Alcohol Ether Sulphate 50 parts, sodium alkyl benzene sulfonate 8 parts, cocoanut fatty acid diethanolamide 2 parts, glycerol 3 parts, about 70-80 DEG C melt and dissolved, to obtain final product.
Embodiment 3
Get each 3 parts of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis, decoct with water twice, first time adds water as 10 times amount of medical material weight, decocts 1.5h, and second time adds water as 8 times amount of medical material weight, decoct 1.5h collecting decoction, be concentrated into 10 times amount of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis gross weight, add Sodium Alcohol Ether Sulphate 60 parts, sodium alkyl benzene sulfonate 10 parts, cocoanut fatty acid diethanolamide 2 parts, glycerol 2 parts, about 70-80 DEG C melt and dissolved, to obtain final product.
Above-mentioned Chinese medicine Fructus Cardiospermi microcarpi is the fruit of sapindaceous plant Herba Cardiospermi microcarpi.Herba Lobeliae taliensis is the root of Campanulaceae Dali Herba Lobeliae Sessilifoliae, latin name Lobelia taliensis Diels.

Claims (2)

1. a Traditional Chinese medicinal hand lotion, it is characterized in that, by Sodium Alcohol Ether Sulphate 40-60 part, sodium alkyl benzene sulfonate 6-10 part, cocoanut fatty acid diethanolamide 1-2 part, glycerol 2-3 part, Fructus Cardiospermi microcarpi 2-4 part, Herba Lobeliae taliensis 2-4 part is prepared from, preparation process is: get Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis, decoct with water twice, first time adds water as the 8-12 times amount of medical material weight, decoct 1-2h, second time adds water as the 6-10 times amount of medical material weight, decoct 1-2h collecting decoction, be concentrated into Fructus Cardiospermi microcarpi, 10 times amount of Herba Lobeliae taliensis gross weight, add Sodium Alcohol Ether Sulphate, sodium alkyl benzene sulfonate, cocoanut fatty acid diethanolamide, glycerol, about 70-80 DEG C melt and dissolved, obtain.
2. the application of Traditional Chinese medicinal hand lotion in preparation Traditional Chinese medicinal hand lotion as claimed in claim 1.
CN201310704635.5A 2013-12-19 2013-12-19 Traditional Chinese medicinal hand lotion Active CN103655361B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104027274A (en) * 2014-06-24 2014-09-10 南京华宽信息咨询中心 Liquid soap
CN108030742A (en) * 2018-01-24 2018-05-15 合肥华盖生物科技有限公司 A kind of warm-natured antibacterial decontamination skin-protection hand cleanser and preparation method thereof

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* Cited by examiner, † Cited by third party
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CN102293731A (en) * 2011-08-25 2011-12-28 宁夏医科大学 Chinese herbal medicinal antibacterial hand cleanser
CN102423291A (en) * 2011-12-30 2012-04-25 山西振东制药股份有限公司 Traditional Chinese medicine antibiotic skincare hand cleanser and preparation method thereof
CN103202949B (en) * 2013-03-04 2014-06-04 余金标 Traditional Chinese medicine for treating chloasma by using cardiospermum halicacabum
CN103211928B (en) * 2013-04-20 2014-08-13 陈志国 External Chinese medicinal ointment for treating chronic osteomyelitis

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