CN103655361A - Traditional Chinese medicinal hand lotion - Google Patents
Traditional Chinese medicinal hand lotion Download PDFInfo
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- CN103655361A CN103655361A CN201310704635.5A CN201310704635A CN103655361A CN 103655361 A CN103655361 A CN 103655361A CN 201310704635 A CN201310704635 A CN 201310704635A CN 103655361 A CN103655361 A CN 103655361A
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- chinese medicine
- handwashing liquid
- herba lobeliae
- traditional chinese
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000006210 lotion Substances 0.000 title abstract 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 16
- 239000011734 sodium Substances 0.000 claims abstract description 16
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 8
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 8
- 239000000194 fatty acid Substances 0.000 claims abstract description 8
- 229930195729 fatty acid Natural products 0.000 claims abstract description 8
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 8
- -1 sodium alkyl benzene Chemical class 0.000 claims abstract description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 229940077388 benzenesulfonate Drugs 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims description 39
- 239000003814 drug Substances 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 14
- 239000012567 medical material Substances 0.000 claims description 10
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 7
- 244000060011 Cocos nucifera Species 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 7
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 7
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 235000013399 edible fruits Nutrition 0.000 abstract description 2
- 241000519324 Cardiospermum microcarpum Species 0.000 abstract 1
- 241000208672 Lobelia Species 0.000 abstract 1
- 150000008051 alkyl sulfates Chemical class 0.000 abstract 1
- 235000019864 coconut oil Nutrition 0.000 abstract 1
- 239000003240 coconut oil Substances 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 description 13
- 239000003153 chemical reaction reagent Substances 0.000 description 10
- 229940079593 drug Drugs 0.000 description 10
- 238000010790 dilution Methods 0.000 description 9
- 239000012895 dilution Substances 0.000 description 9
- 241000222122 Candida albicans Species 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 235000015097 nutrients Nutrition 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 4
- 229940095731 candida albicans Drugs 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 241000194017 Streptococcus Species 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000002949 hemolytic effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 239000006159 Sabouraud's agar Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000193990 Streptococcus sp. 'group B' Species 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 244000309466 calf Species 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 238000009631 Broth culture Methods 0.000 description 1
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 1
- 241000208671 Campanulaceae Species 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001565212 Lobelia taliensis Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides traditional Chinese medicinal hand lotion. The traditional Chinese medicinal hand lotion comprises the following components: 40-60 parts of sodium ethoxylated alkyl sulfate, 6-10 parts of sodium alkyl benzene sulfonate, 1-2 parts of coconut oil fatty acid diethanolamide, 2-3 parts of glycerinum, 2-4 parts of littlefruit heartseed fruit and 2-4 parts of tali lobelia. The traditional Chinese medicinal hand lotion is prepared by a corresponding preparation method and has a good antibacterial effect.
Description
Technical field
The present invention relates to cosmetics technical field, be specifically related to a kind of Chinese medicine handwashing liquid.
Background technology
The main function of handwashing liquid is to play the effect of clean skin protection, and the effect that some specific composition can play sterilization, sterilize is such as escherichia coli etc., along with people's living standard improves day by day, also more and more higher to the prescription of handwashing liquid.Although the handwashing liquid of selling on market is various, a lot of products have added some harmful materials more or less: as bleaching powder, hydrargyrum, cleaning agent, caustic etc.People there is also a desire for more excellent handwashing liquid, particularly utilize Chinese medicine to prepare handwashing liquid.
Summary of the invention
Goal of the invention: in order to address the above problem, the object of the present invention is to provide a kind of handwashing liquid and preparation method thereof.
Technical scheme: the object of the invention is to realize by following scheme:
A Chinese medicine handwashing liquid, is comprised of Sodium Alcohol Ether Sulphate 40-60 part, sodium alkyl benzene sulfonate 6-10 part, cocoanut fatty acid diethanolamide 1-2 part, glycerol 2-3 part, Fructus Cardiospermi microcarpi 2-4 part, Herba Lobeliae taliensis 2-4 part.
Above-mentioned Chinese medicine handwashing liquid, preparation process is: get Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis, decoct with water twice, the 8-12 that adds for the first time water and be medical material weight doubly measures, decoct 1-2h, the 6-10 that adds for the second time water and be medical material weight doubly measures, and decocts 1-2h collecting decoction, is concentrated into 10 times of amounts of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis gross weight, add Sodium Alcohol Ether Sulphate, sodium alkyl benzene sulfonate, cocoanut fatty acid diethanolamide, glycerol, 70-80 ℃ of left and right is melt and dissolved, obtains.
The application of above-mentioned Chinese medicine handwashing liquid in preparing Chinese medicine handwashing liquid.
Beneficial effect:
Nourish blood dampness removing and Herba Lobeliae taliensis heat-clearing and toxic substances removing of Fructus Cardiospermi microcarpi in the present invention, both compatibilities, fungistatic effect is good, is the affect result of the test of the present invention on staphylococcus aureus below.
1 test material
(1) medicine and reagent
Be subject to reagent: by Preparation Example 3 methods, prepare Chinese medicine handwashing liquid, be the present invention: specification: 2g crude drug/g, lot number: 20120503; And according to the method for embodiment 3, remove the handwashing liquid that Fructus Cardiospermi microcarpi preparation only contains Herba Lobeliae taliensis, remove the handwashing liquid that Herba Lobeliae taliensis only contains Fructus Cardiospermi microcarpi; Sodium chloride: Shanghai Jiu Yi chemical reagent company limited, lot number: 00060120.Nutrient broth medium: CAS Shanghai Insect Bio Technological Development Co., Ltd., lot number: 110516.Nutrient agar: microorganism reagent factory of Jiangsu Prov. Disease Preventing and Controlling Center, lot number: 110016.Improvement Martin culture medium: Hangzhou Tian He microorganism reagent company limited, lot number: 100831.Improvement Martin culture medium: Beijing San Yao scientific and technological development company, lot number: 111213; Sabouraud's agar: Beijing Luqiao Technology Co., Ltd. of China Inst. of Quarantine Inspection Sciences, lot number: 1007153; Calf serum, Hangzhou Sijiqing Biological Engineering Material Co., Ltd., lot number: 100508; De-fine Sheep Blood, purchased from Jiangning county epidemic prevention station, lot number: 120312
(2) bacterial strain
Reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210) are provided by disease control and prevention center, Jiangsu Province microorganism reagent factory; Candida albicans (98100) is provided by institute for drug control, Jiangsu Province.
(3) instrument and equipment
Electronic balance, Beijing Sai Duolisi balance company limited produces; Full-automatic high-pressure autoclave, Japanese SANYO;
Superclean bench, Suzhou Decontamination Equipment Plant; SHP-80 biochemical cultivation case, the gloomy reliable Instrument Ltd. that tests in Shanghai
2 experimental techniques
(1) antibacterial culturing
Get reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210) bacterial strain a little, be inoculated in respectively in nutrient broth medium, cultivate 18h for 37 ℃.(in group B streptococcus broth bouillon, adding 20% calf serum) gets each bacterial strain nutrient broth culture that 18h cultivates, and with nutrient broth, does 10-3 dilution for experiment.Extracting waste candidiasis bacterial strain a little, be inoculated in improvement Martin culture medium, cultivate 24h for 35 ℃.Get the Candida albicans culture that 24h cultivates, with improvement Martin culture medium 10-3 dilution, be used for experiment.
(2) doubling dilution (test tube method)
Get 11 of sterilizing test tubes, the 1st pipe adds nutrient broth fluid medium 1.6ml, all the other every pipe 1ml, get respectively and added in the first pipe by reagent diluent 0.4ml, after mixing, get 1ml to the 2 pipes, dilution successively, the 10th pipe sucking-off 1ml discards, and the 11st pipe does not add medicinal liquid in contrast.Every pipe adds dilution bacterium liquid 0.1ml, cultivates 24h for 37 ℃.Take out the bacterial growth situation of observing.As drug liquid tube is muddy, represent bacterial growth, supply reagent thing without bacteriostasis; As limpidly in drug liquid tube represent that bacterial growth is suppressed, the medicinal liquid of the greatest dilution that it can bacteria growing inhibiting, is the minimal inhibitory concentration (MIC) of this medicine.Limpid medicinal liquid meat soup is respectively managed to transferred species bouillon agar flat board, cultivate 24h and observe, still without the minimum drug level of bacterial growth, be the bacteriocidal concentration of this medicine.
Get 11 of sterilizing test tubes, the 1st pipe adds improvement Martin fluid medium 1.6ml, all the other every pipe 1ml, get respectively and added in the first pipe by reagent diluent 0.4ml, after mixing, get 1ml to the 2 pipes, dilution successively, the 10th pipe sucking-off 1ml discards, and the 11st pipe does not add medicinal liquid in contrast.Every pipe adds dilution bacterium liquid 0.1ml, cultivates 24h for 35 ℃, takes out the bacterial growth situation of observing.As drug liquid tube is muddy, represent bacterial growth, supply reagent thing without bacteriostasis; As limpidly in drug liquid tube represent that bacterial growth is suppressed, the medicinal liquid of the greatest dilution that it can bacteria growing inhibiting, is the minimal inhibitory concentration (MIC) of this medicine.Limpid medicinal liquid meat soup is respectively managed to transferred species sabouraud's agar flat board, cultivate 24h and observe, still without the minimum drug level of bacterial growth, be the bacteriocidal concentration of this medicine.
3 results
Experimental result shows: Chinese medicine handwashing liquid of the present invention is to reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210), Candida albicans all have stronger bacteriostasis, and MIC press the calculating of crude drug amount at 0.05g～0.2g/g().In Table 1.
Table 1 antibacterial activity in vitro of the present invention (n=2) unit: minimum inhibitory concentration (MIC) (g crude drug/g)
| Bacterial strain | The present invention | The handwashing liquid that only contains Herba Lobeliae taliensis | The handwashing liquid that only contains Fructus Cardiospermi microcarpi |
| Staphylococcus aureus (standard) | 0.3**# | 0.1 | 0.1 |
| Escherichia coli (standard) | 0.4*## | 0.05 | 0.1 |
| Group B streptococcus (standard) | 0.3*# | 0.05 | 0.05 |
| Candida albicans | 0.5**# | 0.1 | 0.05 |
Legend: compare * P<0.05 with the plant liquid soap that only contains Herba Lobeliae taliensis; * p<0.01, compares #P<0.05 with the plant liquid soap that only contains Fructus Cardiospermi microcarpi; ##p<0.013.1.4 conclusion
Chinese medicine handwashing liquid of the present invention has good bacteriostasis,, and there is significant difference with the handwashing liquid that only contains the handwashing liquid of Herba Lobeliae taliensis or only contain Fructus Cardiospermi microcarpi.
The specific embodiment
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to following example, all technology realizing based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1
Get each 2 parts of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis, decoct with water twice, adding for the first time water is 8 times of amounts of medical material weight, decocts 1h, and adding for the second time water is 6 times of amounts of medical material weight, decoct 1h collecting decoction, be concentrated into 10 times of amounts of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis gross weight, add 40 parts of Sodium Alcohol Ether Sulphate, 6 parts of sodium alkyl benzene sulfonates, 1 part of cocoanut fatty acid diethanolamide, 2 parts of glycerol, 70-80 ℃ of left and right is melt and dissolved, obtains.
Embodiment 2
Get each 4 parts of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis, decoct with water twice, adding for the first time water is 12 times of amounts of medical material weight, decocts 2h, and adding for the second time water is 10 times of amounts of medical material weight, decoct 2h collecting decoction, be concentrated into 10 times of amounts of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis gross weight, add 50 parts of Sodium Alcohol Ether Sulphate, 8 parts of sodium alkyl benzene sulfonates, 2 parts of cocoanut fatty acid diethanolamides, 3 parts of glycerol, 70-80 ℃ of left and right is melt and dissolved, obtains.
Embodiment 3
Get each 3 parts of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decocts 1.5h, and adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h collecting decoction, be concentrated into 10 times of amounts of Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis gross weight, add 60 parts of Sodium Alcohol Ether Sulphate, 10 parts of sodium alkyl benzene sulfonates, 2 parts of cocoanut fatty acid diethanolamides, 2 parts of glycerol, 70-80 ℃ of left and right is melt and dissolved, obtains.
Above-mentioned Chinese medicine Fructus Cardiospermi microcarpi is the fruit of sapindaceous plant Herba Cardiospermi microcarpi.Herba Lobeliae taliensis is the root of Campanulaceae Dali Herba Lobeliae Sessilifoliae, latin name Lobelia taliensis Diels.
Claims (3)
1. a Chinese medicine handwashing liquid, is characterized in that, Sodium Alcohol Ether Sulphate 40-60 part, sodium alkyl benzene sulfonate 6-10 part, cocoanut fatty acid diethanolamide 1-2 part, glycerol 2-3 part, Fructus Cardiospermi microcarpi 2-4 part, Herba Lobeliae taliensis 2-4 part, consists of.
2. Chinese medicine handwashing liquid as claimed in claim 1, is characterized in that, preparation process is: get Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis, decoct with water twice, the 8-12 that adds for the first time water and be medical material weight doubly measures, and decocts 1-2h, and the 6-10 that adds for the second time water and be medical material weight doubly measures, decoct 1-2h collecting decoction, 10 times of amounts that are concentrated into Fructus Cardiospermi microcarpi, Herba Lobeliae taliensis gross weight, add Sodium Alcohol Ether Sulphate, sodium alkyl benzene sulfonate, cocoanut fatty acid diethanolamide, glycerol, 70-80 ℃ of left and right is melt and dissolved, obtains.
3. the application of Chinese medicine handwashing liquid in Chinese medicine handwashing liquid as claimed in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310704635.5A CN103655361B (en) | 2013-12-19 | 2013-12-19 | Traditional Chinese medicinal hand lotion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310704635.5A CN103655361B (en) | 2013-12-19 | 2013-12-19 | Traditional Chinese medicinal hand lotion |
Publications (2)
| Publication Number | Publication Date |
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| CN103655361A true CN103655361A (en) | 2014-03-26 |
| CN103655361B CN103655361B (en) | 2015-07-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310704635.5A Active CN103655361B (en) | 2013-12-19 | 2013-12-19 | Traditional Chinese medicinal hand lotion |
Country Status (1)
| Country | Link |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027274A (en) * | 2014-06-24 | 2014-09-10 | 南京华宽信息咨询中心 | Liquid soap |
| CN108030742A (en) * | 2018-01-24 | 2018-05-15 | 合肥华盖生物科技有限公司 | A kind of warm-natured antibacterial decontamination skin-protection hand cleanser and preparation method thereof |
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|---|---|---|---|---|
| CN102293731A (en) * | 2011-08-25 | 2011-12-28 | 宁夏医科大学 | Chinese herbal medicinal antibacterial hand cleanser |
| CN102423291A (en) * | 2011-12-30 | 2012-04-25 | 山西振东制药股份有限公司 | Traditional Chinese medicine antibiotic skincare hand cleanser and preparation method thereof |
| CN103202949A (en) * | 2013-03-04 | 2013-07-17 | 余金标 | Traditional Chinese medicine for treating chloasma by using cardiospermum halicacabum |
| CN103211928A (en) * | 2013-04-20 | 2013-07-24 | 陈志国 | External Chinese medicinal ointment for treating chronic osteomyelitis |
-
2013
- 2013-12-19 CN CN201310704635.5A patent/CN103655361B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293731A (en) * | 2011-08-25 | 2011-12-28 | 宁夏医科大学 | Chinese herbal medicinal antibacterial hand cleanser |
| CN102423291A (en) * | 2011-12-30 | 2012-04-25 | 山西振东制药股份有限公司 | Traditional Chinese medicine antibiotic skincare hand cleanser and preparation method thereof |
| CN103202949A (en) * | 2013-03-04 | 2013-07-17 | 余金标 | Traditional Chinese medicine for treating chloasma by using cardiospermum halicacabum |
| CN103211928A (en) * | 2013-04-20 | 2013-07-24 | 陈志国 | External Chinese medicinal ointment for treating chronic osteomyelitis |
Non-Patent Citations (1)
| Title |
|---|
| 陈晓兰: "一些药用植物对5种植物病原真菌的抗菌活性", 《华中农业大学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027274A (en) * | 2014-06-24 | 2014-09-10 | 南京华宽信息咨询中心 | Liquid soap |
| CN108030742A (en) * | 2018-01-24 | 2018-05-15 | 合肥华盖生物科技有限公司 | A kind of warm-natured antibacterial decontamination skin-protection hand cleanser and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN103655361B (en) | 2015-07-15 |
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