CN104815117A - Traditional Chinese medicine gel for treating kysthitis and preparation method and application of traditional Chinese medicine gel - Google Patents
Traditional Chinese medicine gel for treating kysthitis and preparation method and application of traditional Chinese medicine gel Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine preparations and particularly discloses a traditional Chinese medicine gel. The gel is prepared from the following raw materials in parts by weight: 20 parts of begonia pedatifida, 15 parts of oreocharis benthamii, 12 parts of juncus effuses, 18 parts of elongated swertia herb, 12 parts of lemmaphyllum microphyllum, 2 parts of carbomer, 25 parts of propylene glycol, 2 parts of ethanol, 2 parts of azone, 3 parts of triethanolamine and 150 parts of distilled water. The traditional Chinese medicine gel has the efficacies of dispelling wind, arresting itching, removing dampness and destroying parasites and is used for treating kysthitis.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to one and treat colpitic Chinese medicine gel and its preparation method and application.
Background technology
Vaginitis is one of women's frequently-occurring disease, has a strong impact on their quality of life, and its treatment is transitioned into low dosage vagina administration gradually by whole body estrin treatment in the past.To colpitic treatment, Chinese and western medicine has his own strong points, western medicine instant effect, but easily produces drug resistance, often the recurrent exerbation because treatment is not thorough; Treatment by Chinese herbs takes effect slowly, but curative effect is more stable, and side effect is little.Market lacks the Chinese medicine gel with better effects.
Summary of the invention
The object of the invention is open a kind of good effect, easy to use, the colpitic Chinese medicine gel for the treatment of that side effect is little.
Another object of the present invention is to provide preparation method and the purposes of this Traditional Chinese medicinal gel preparation.
The present invention is achieved through the following technical solutions:
One treats colpitic Chinese medicine gel, extracted by following bulk drugs and adjuvant weight and be prepared from: the palm splits 15 parts, lotus on Flos Begoniae Evansianae 20 parts, stone, wild seat grass 12 parts, Herba Swertiae davidi 18 parts, Drymoglossum Herba Drymoglossi 12 parts, carbomer 2 parts, propylene glycol 25 parts, ethanol 2 parts, azone 2 parts, triethanolamine 3 parts, distilled water 150 parts.
The colpitic Chinese medicine gel of described treatment, preparation method comprises the steps:. gets the above-mentioned palm and splits Flos Begoniae Evansianae, Shi Shanglian, wild seat grass, Herba Swertiae davidi, Drymoglossum Herba Drymoglossi medical material, decoct 2 times, add weight 12 times amount soak by water 2 hours at every turn, filter, merging filtrate, when being evaporated to 70 DEG C, relative density is 1.1, add ethanol to the volume ratio of alcohol content and reach 60%, leave standstill 48 hours, filter, collect filtrate, decompression recycling ethanol, and filtrate is concentrated into 70 DEG C time, often rise volume concentrated solution containing the concentrated solution of crude drug amount 2kg, obtain extraction concentrated solution; Get carbomer adding distil water fully swelling, get extraction concentrated solution and add wherein, stir and make into gel-type vehicle; Add propylene glycol, azone mix homogeneously, getting triethanolamine adjust ph is 5.0, stirs and get final product.
The application of the colpitic Chinese medicine gel of described treatment in preparation treatment colpitis medicine.
It is that the Begoniaceae Begonia plant palm splits Flos Begoniae Evansianae Begonia pedatifida Levl. and is used as medicine with root stock that the palm splits Flos Begoniae Evansianae.Autumn and winter excavate, and clean section is dried.Dissipating blood stasis, hemostasia and detumescence, pain relieving.For spitting blood, metrorrhagia, stomachache, rheumatic arthritis; External is controlled traumatic injury and is swollen and ache, venom.
Shi Shanglian is Gesneriaceae herbaceos perennial.Classification system Oreocharis benthamii, controls the diseases such as traumatic injury.Removing damp-heat, diuretic softening the hard mass, reducing swelling and alleviating pain.Treating hepatocirrhosis, ascites, summer-heat is thirsty.Treating swelling and pain by traumatic injury is controlled in external, furuncle swelling toxin.The present invention is with all herbal medicine.
Wild seat grass is Cyperaceae Cyperus plant cyperus iria Cyperus iria L., with all herbal medicine.Xia Qiu gathers, using fresh herb or dry.Expelling wind and removing dampness, regulating menstruation diuresis.For rheumatism bones and muscles pain, traumatic injury, menoxenia, dysmenorrhea, amenorrhea, lithangiuria.
Herba Swertiae davidi is the herb of Gentianaceae Swertia plant Herba Swertiae davidi Swertia davidi Franch..Xia Qiu gathers, using fresh herb or dry.Clearing away lung-heat, parasite killing.For jaundice due to damp-heat, larynx is red and swollen, malignant boil scabies.
Drymoglossum Herba Drymoglossi is that Polypodiaceae Drymoglossum Herba Drymoglossi belongs to small-sized Epiphyte, the antipyretic antiinflammatory of energy, wind dispelling cold expelling, clearing away lung-heat to relieve cough and hemostasis.Classification system is Drymoglossum piloselloides (L.) C.Presl, heat-clearing and toxic substances removing, hemostasia and detumescence.For jaundice, tuberculous lymphadenitis, parotitis, hemoptysis of pulmonary tuberculosis, metrorrhagia, breast carcinoma, traumatic injury.The present invention is with all herbal medicine.
It is monarch drug that prescription of the present invention splits lotus removing damp-heat on Flos Begoniae Evansianae, stone by the palm, and wild seat grass, Herba Swertiae davidi parasite killing are ministerial drug, and Drymoglossum Herba Drymoglossi is adjuvant, and by above-mentioned all medicine compatibilities, full side has effect of dispelling wind for relieving itching, removing dampness and killing parasites, for vaginitis.
Detailed description of the invention
Embodiment 1: get the palm and split Flos Begoniae Evansianae 20g, lotus 15g on stone, wild seat grass 12g, Herba Swertiae davidi 18g, Drymoglossum Herba Drymoglossi 12g, carbomer 2g, propylene glycol 25g, ethanol 2g, azone 2g, triethanolamine 3g, distilled water 150g, get the above-mentioned palm and split Flos Begoniae Evansianae, Shi Shanglian, wild seat grass, Herba Swertiae davidi, Drymoglossum Herba Drymoglossi medical material, decoct 2 times, add weight 12 times amount soak by water 2 hours at every turn, filter, merging filtrate, when being evaporated to 70 DEG C, relative density is 1.1, add ethanol to the volume ratio of alcohol content and reach 60%, leave standstill 48 hours, filter, collect filtrate, decompression recycling ethanol, and filtrate is concentrated into the concentrated solution that often rises volume the 70 DEG C time concentrated solution containing crude drug amount 2kg, concentrated solution must be extracted, get carbomer adding distil water fully swelling, get extraction concentrated solution and add wherein, stir and make into gel-type vehicle, add propylene glycol, azone mix homogeneously, getting triethanolamine adjust ph is 5.0, stirs and get final product.
2. pharmacological evaluation of the present invention
2.1 extracorporeal bacteria inhibitor tests of the present invention
Test objective: adopt certain culture medium to cultivate the vaginal bacteria be recently separated or mycete, observe In Vitro Bacteriostasis of the present invention, and measure its minimum antibacterial crude drug consumption concentration.
2.1.1 test material
(1) medicine and reagent
By reagent: prepare Chinese medicine gel by above-mentioned preparation embodiment 1 method, be the present invention: specification: 2g crude drug/g, lot number: 20120503; Sodium chloride: Shanghai hundred million chemical reagent company limiteies of a specified duration, lot number: 00060120.Nutrient broth medium: CAS Shanghai Insect Bio Technological Development Co., Ltd., lot number: 110516.Nutrient agar: microorganism reagent factory of Jiangsu Prov. Disease Preventing and Controlling Center, lot number: 110016.Improvement Martin culture medium: sky, Hangzhou and microorganism reagent company limited, lot number: 100831.Improvement Martin culture medium: Beijing three medicine scientific and technological development company, lot number: 111213; Sabouraud's agar: Beijing Luqiao Technology Co., Ltd. of China Inst. of Quarantine Inspection Sciences, lot number: 1007153; Calf serum, Hangzhou Sijiqing Biological Engineering Material Co., Ltd., lot number: 100508; De-fine Sheep Blood, purchased from Jiangning county epidemic prevention station, lot number: 120312
(2) bacterial strain
Reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210) are provided by Disease epizootic prevention center microorganism reagent factory of Jiangsu Province; Candida albicans (98100) is provided by institute for drug control, Jiangsu Province.
(3) instrument and equipment
Electronic balance, Beijing Sai Duolisi balance company limited produces; Full-automatic high-pressure autoclave, Japanese SANYO;
Superclean bench, Suzhou Decontamination Equipment Plant; SHP-80 biochemical cultivation case, Shanghai is gloomy reliablely tests Instrument Ltd.
2.1.2 experimental technique
(1) antibacterial culturing
Get reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210) bacterial strain a little, are inoculated in nutrient broth medium respectively, cultivate 18h for 37 DEG C.(adding 20% calf serum in group B streptococcus broth bouillon) gets each bacterial strain nutrient broth culture that 18h cultivates, and does 10-3 dilution for experiment with nutrient broth.Extracting waste candidiasis bacterial strain is a little, is inoculated in improvement Martin culture medium, cultivates 24h for 35 DEG C.Get the Candida albicans culture that 24h cultivates, be used for experiment with improvement Martin culture medium 10-3 dilution.
(2) doubling dilution (test tube method)
Get sterilizing test tubes 11, the 1st pipe adds nutrient broth fluid medium 1.6ml, and all the other are pipe 1ml often, get respectively and add in the first pipe by reagent diluent 0.4ml, get 1ml after mixing to the 2nd pipe, dilute successively, 10th pipe sucking-off 1ml discards, and the 11st pipe does not add medicinal liquid in contrast.Often pipe adds dilution bacterium liquid 0.1ml, cultivates 24h for 37 DEG C.Take out and observe bacterial growth situation.As drug liquid tube is muddy, namely represent bacterial growth, for reagent thing without bacteriostasis; As drug liquid tube is limpid, represent that bacterial growth is suppressed, the medicinal liquid of the greatest dilution of its energy bacteria growing inhibiting, is the minimal inhibitory concentration (MIC) of this medicine.By limpid medicinal liquid meat soup each pipe transferred species broth agar plates, cultivate 24h and observe, be still the bacteriocidal concentration of this medicine without the minimum drug level of bacterial growth.
Get sterilizing test tubes 11, the 1st pipe adds improvement Martin fluid medium 1.6ml, and all the other are pipe 1ml often, get respectively and add in the first pipe by reagent diluent 0.4ml, get 1ml after mixing to the 2nd pipe, dilute successively, 10th pipe sucking-off 1ml discards, and the 11st pipe does not add medicinal liquid in contrast.Often pipe adds dilution bacterium liquid 0.1ml, cultivates 24h for 35 DEG C, takes out and observe bacterial growth situation.As drug liquid tube is muddy, namely represent bacterial growth, for reagent thing without bacteriostasis; As drug liquid tube is limpid, represent that bacterial growth is suppressed, the medicinal liquid of the greatest dilution of its energy bacteria growing inhibiting, is the minimal inhibitory concentration (MIC) of this medicine.Limpid medicinal liquid meat soup each pipe transferred species sabouraud's agar is dull and stereotyped, cultivate 24h and observe, be still the bacteriocidal concentration of this medicine without the minimum drug level of bacterial growth.
2.1.3 result
Experimental result shows: the present invention is to reference culture: staphylococcus aureus (ATCC25923), escherichia coli (441490), beta hemolytic streptococcus (32210), Candida albicans all have stronger bacteriostasis, and MIC is at 01g ~ 0.3g/g (by raw medicine calculation).In table 1.
Table 1 antibacterial activity in vitro of the present invention (n=2)
| Bacterial strain | Minimum inhibitory concentration (MIC) (g crude drug/g) |
| Staphylococcus aureus (standard) | 0.2 |
| Escherichia coli (standard) | 0.2 |
| Group B streptococcus (standard) | 0.1 |
| Candida albicans | 0.3 |
2.1.4 conclusion: the present invention has good bacteriostasis, can be used for treating vaginitis.
Claims (3)
1. the colpitic Chinese medicine gel for the treatment of, it is characterized in that being extracted by following bulk drugs and adjuvant weight being prepared from: the palm splits 15 parts, lotus on Flos Begoniae Evansianae 20 parts, stone, wild seat grass 12 parts, Herba Swertiae davidi 18 parts, Drymoglossum Herba Drymoglossi 12 parts, carbomer 2 parts, propylene glycol 25 parts, ethanol 2 parts, azone 2 parts, triethanolamine 3 parts, distilled water 150 parts.
2. treat colpitic Chinese medicine gel as claimed in claim 1, it is characterized in that preparation method comprises the steps:. get the above-mentioned palm and split Flos Begoniae Evansianae, Shi Shanglian, wild seat grass, Herba Swertiae davidi, Drymoglossum Herba Drymoglossi medical material, decoct 2 times, add weight 12 times amount soak by water 2 hours at every turn, filter, merging filtrate, when being evaporated to 70 DEG C, relative density is 1.1, add ethanol to the volume ratio of alcohol content and reach 60%, leave standstill 48 hours, filter, collect filtrate, decompression recycling ethanol, and filtrate is concentrated into the concentrated solution that often rises volume the 70 DEG C time concentrated solution containing crude drug amount 2kg, concentrated solution must be extracted, get carbomer adding distil water fully swelling, get extraction concentrated solution and add wherein, stir and make into gel-type vehicle, add propylene glycol, azone mix homogeneously, getting triethanolamine adjust ph is 5.0, stirs and get final product.
3. treat the application of colpitic Chinese medicine gel in treatment colpitis medicine as claimed in claim 1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177454A (en) * | 2016-07-18 | 2016-12-07 | 南京正宽医药科技有限公司 | One treats colpitic gel and preparation method thereof |
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| CN102793881A (en) * | 2012-09-07 | 2012-11-28 | 南京市妇幼保健院 | Traditional Chinese medicine gel for treating vaginitis as well as preparation method and application of traditional Chinese medicine gel |
| CN103494958A (en) * | 2013-09-27 | 2014-01-08 | 周莉 | Traditional Chinese medicine lotion for treating gynecological inflammations as well as preparation method thereof |
| CN103893655A (en) * | 2014-04-24 | 2014-07-02 | 郑家林 | Traditional Chinese medicine external lotion for treating gynecologic colpitis |
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2015
- 2015-05-26 CN CN201510275525.0A patent/CN104815117A/en active Pending
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| CN1413683A (en) * | 2002-11-13 | 2003-04-30 | 贵州和仁堂药业有限公司 | Medicine for treating gynecopathy |
| CN1489990A (en) * | 2003-09-12 | 2004-04-21 | 南京中医药大学 | Preparing method for superfine Chinese medicine jellies |
| CN102793881A (en) * | 2012-09-07 | 2012-11-28 | 南京市妇幼保健院 | Traditional Chinese medicine gel for treating vaginitis as well as preparation method and application of traditional Chinese medicine gel |
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