CN101502537A - Application of ginkgo episperm dry distillation liquid in preparing medicament for treating or preventing fungal disease - Google Patents
Application of ginkgo episperm dry distillation liquid in preparing medicament for treating or preventing fungal disease Download PDFInfo
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- CN101502537A CN101502537A CNA2007100999044A CN200710099904A CN101502537A CN 101502537 A CN101502537 A CN 101502537A CN A2007100999044 A CNA2007100999044 A CN A2007100999044A CN 200710099904 A CN200710099904 A CN 200710099904A CN 101502537 A CN101502537 A CN 101502537A
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Abstract
The invention discloses an application of ginkgo biloba exocarp dry distillation liquid in the preparation of drugs for treating or preventing fungal diseases, belonging to the field of traditional Chinese medicine, wherein, the ginkgo biloba exocarp dry distillation liquid is obtained by the dry distillation method. The ginkgo biloba exocarp dry distillation liquid is a pure natural product with simple process, low cost, no toxic side effects and significant efficacy, thereby leading ginkgo biloba exocarp to be reasonably and fully utilized and turning waste into treasure.
Description
Technical field
The present invention relates to the application of a kind of ginkgo episperm dry distillation liquid in the medicine of preparation treatment or prevention fungal disease, belong to the field of Chinese medicines.
Background technology
Semen Ginkgo is precious in the world medicinal plants, and its leaf, fruit and episperm etc. all have higher medicinal exploitation and be worth.The Semen Ginkgo dry distillation liquid preparation that is developed to by Folium Ginkgo is one of natural drug popular to people deeply at present, and the various nutraceutical that formed by the Semen Ginkgo exploitation are also a lot, but the utilization rate of gingko episperm is lower.According to statistics, China has 30,000 tons episperm to be dropped as refuse every year approximately, and discovers that gingko episperm has various pharmacological activities, has higher value.
And at present, in the pharmacological research to gingko episperm, also only be to study at the resulting composition of solvent extraction method.Also do not adopt cracking process to obtain dry distillation liquid, the report of studying to gingko episperm.
The objective of the invention is for the application of a kind of ginkgo episperm dry distillation liquid in the middle of the medicine of preparation treatment or prevention fungal disease is provided, applied ginkgo episperm dry distillation liquid obtains by cracking process in this narration.Thereby gingko episperm is rationally utilized fully, turn waste into wealth.
Summary of the invention
One of purpose of the present invention provides the application of a kind of ginkgo episperm dry distillation liquid in the middle of the medicine of preparation treatment or prevention fungal disease;
Two of purpose of the present invention provides the concrete grammar of this application.
The present invention seeks to be achieved through the following technical solutions:
Ginkgo episperm dry distillation liquid of the present invention is made by following method:
A. the gingko episperm with purchase removes various impurity, cleans;
B. it is dried naturally;
C. gingko episperm is packed in the dry distilling container, be heated to 90～120 ℃ and carry out dry distilling, steam is collected liquid through condensing tube condensation, discards;
E. improve heating-up temperature to 150～500 ℃ when no liquid flows out the back, be incubated 2～10 hours, continue dry distilling, steam is collected liquid through condensing tube condensation, flows out until no liquid, stops heating, lowers the temperature and removes the gred;
F. the liquid that (e) collected, 80～100 ℃ of heating in water bath 30 minutes obtain ginkgo episperm dry distillation stock solution;
Above-mentioned stock solution can also continue redistillation and obtain rectification liquid: quantitatively take by weighing above-mentioned ginkgo episperm dry distillation stock solution, add distilled water, making original liquid concentration is 30%～80%, stirs into homogeneous mixture; Mixture packed into distill in the container that has agitating device, under stirring state, progressively heat up; The control temperature is collected distillate between 100～130 ℃, obtain gingko episperm rectification liquid.
Above stock solution or rectification liquid can be made many preparations, comprise washing liquid, gel, suppository, spray, liniment, ointment, patch, vagina effervescence, tincture, shampoo etc.
Above stock solution or rectification liquid can be used for preparing the medicine of treatment or prevention fungal disease, are to determine drug effect, and stock solution and rectification liquid have been carried out external pharmacodynamics bactericidal assay and bacteriostatic test research, and used stock solution and rectification liquid are following prepared and getting in the test:
A. gingko episperm is removed various impurity, clean;
B. it is dried naturally;
C. gingko episperm is packed in the dry distilling container, be heated to 90～120 ℃ and carry out dry distilling, steam is collected liquid through condensing tube condensation, discards;
E. improve heating-up temperature to 150～500 ℃ when no liquid flows out the back, be incubated 5 hours, continue dry distilling, steam is collected liquid through condensing tube condensation, flows out until no liquid, stops heating, lowers the temperature and removes the gred;
F. the liquid that (e) collected, 80～100 ℃ of heating in water bath 30 minutes obtain ginkgo episperm dry distillation stock solution;
G. measure above-mentioned ginkgo episperm dry distillation stock solution 100ml, add distilled water 100ml, stir into homogeneous mixture; Mixture packed into distill in the container that has agitating device, under stirring state, progressively heat up; The control temperature is collected distillate between 100～130 ℃, obtain gingko episperm rectification liquid.
The extracorporeal disinfecting test is as follows:
Test apparatus: autoclave sterilizer DW400/50L, electro-heating standing-temperature cultivator SPK-01, electronic balance PB303-E
Culture medium:
Bacterium liquid preparation: 10 times of dilution methods
Test procedure:
1. medicinal liquid dilution: prepare a series of test tubes that the 1.0ml fluid medium is housed, in the 1st pipe, add the 1.0ml medicinal liquid, mixing back absorption 1.0ml adds in the 2nd pipe, be diluted to the 12nd pipe with method, from the 12nd pipe, take out 1.0ml and sterilize empty test tube as blank, the positive control tube of the 13rd pipe in one.
2. add bacterium liquid: each test tube adds 50 μ l bacterium liquid.
3. cultivate: place 36 ℃ to cultivate observed result 18-24 hour in each test tube.
4. determining of minimum bactericidal concentration (MBC): successively the culture of respectively managing of asepsis growth is respectively drawn 50 μ l and coated on the agar culture medium flat board, dull and stereotyped numbering is corresponding with the test tube numbering, cultivated 18-24 hour for 36 ℃, the clump count on the flat board is minimal bactericidal concentration less than the drug level of 5 high dilution.
Result of the test:
Annotate :+dull and stereotyped long bacterium is not less than 5; Not long bacterium of-flat board or long bacterium clump count are less than 5; Represent liquor strength with extension rate.1: ginkgo episperm dry distillation stock solution, 2: ginkgo episperm dry distillation rectification liquid, 3: like product is to be the preparation of feedstock production with the dry distillation liquid of Chinese hawthorn seed in the market, so be equipped with Semen Crataegi dry distilling stock solution in contrast with legal system
Conclusion (of pressure testing): be by the definite minimum bactericidal concentration of extracorporeal disinfecting test to trichophyton
Ginkgo episperm dry distillation stock solution: be diluted to 256 times
Ginkgo episperm dry distillation rectification liquid: be diluted to 256 times
Semen Crataegi dry distilling stock solution with the method preparation: be diluted to 128 times
Determine by extracorporeal disinfecting test to be to the oidiomycetic minimum bactericidal concentration of white
Ginkgo episperm dry distillation stock solution: be diluted to 128 times
Ginkgo episperm dry distillation rectification liquid: be diluted to 128 times
Semen Crataegi dry distilling stock solution with the method preparation: be diluted to 64 times
By the extracorporeal disinfecting evidence ginkgo episperm dry distillation liquid to being that the fungus of representative has good killing effect with Candida albicans and trichophyton.Use above effect, ginkgo episperm dry distillation liquid can be prepared into the multiple medicine that takes orally or be coated with outward, be used for the treatment of or prevent the Mycophyta disease, comprise that woman such as senile vaginitis, bacterial vaginitis, colpitis mycotica, trichomonal vaginitis are colpitis, also have diseases such as the fungal infection dermatoses and the dandruff; Also can be used to prepare hair washing product, be used for the treatment of or prevent and treat diseases such as the mycetogenetic dandruff.
Below by implementing to further specify technical scheme of the present invention, but this applies for that claimed scope is not limited in the described content of embodiment.
The specific embodiment:
Embodiment 1
Gingko episperm 50kg is removed various impurity, clean, it is dried naturally; Gingko episperm is packed in the dry distilling container, be heated to 90～105 ℃ and carry out dry distilling, steam is collected liquid through condensing tube condensation, discards.Improve heating-up temperature to 150～380 ℃ when no liquid flows out the back, be incubated 4 hours, continue dry distilling, steam is collected liquid through condensing tube condensation, flows out until no liquid, stops heating, lowers the temperature and removes the gred.With the liquid of above-mentioned collection, 85 ℃ of heating in water bath 30 minutes obtain ginkgo episperm dry distillation stock solution.
Get ginkgo episperm dry distillation stock solution 300ml, add tween 80 250g, mixing, adding distil water make washing liquid to 1000ml.
Embodiment 2
Gingko episperm 250kg is removed various impurity, clean, it is dried naturally; Gingko episperm is packed in the dry distilling container, be heated to 95～110 ℃ and carry out dry distilling, steam is collected liquid through condensing tube condensation, discards.Improve heating-up temperature to 150～400 ℃ when no liquid flows out the back, be incubated 6 hours, continue dry distilling, steam is collected liquid through condensing tube condensation, flows out until no liquid, stops heating, lowers the temperature and removes the gred.With the liquid of above-mentioned collection, 90 ℃ of heating in water bath 30 minutes obtain ginkgo episperm dry distillation stock solution.Quantitatively take by weighing above-mentioned ginkgo episperm dry distillation stock solution, add distilled water, making original liquid concentration is 50%, stirs into homogeneous mixture.Mixture packed into distill in the container that has agitating device, progressively heat up under stirring state, the control temperature is collected distillate, promptly between 105～110 ℃.
Get ginkgo episperm dry distillation rectification liquid 300ml, adding distil water is to 1000ml, and it is an amount of to add sodium carboxymethyl cellulose, makes gel.
Embodiment 3
Gingko episperm 500kg is removed various impurity, clean, it is dried naturally; Gingko episperm is packed in the dry distilling container, be heated to 100～120 ℃ and carry out dry distilling, steam is collected liquid through condensing tube condensation, discards.Improve heating-up temperature to 150～480 ℃ when no liquid flows out the back, be incubated 8 hours, continue dry distilling, steam is collected liquid through condensing tube condensation, flows out until no liquid, stops heating, lowers the temperature and removes the gred.With the liquid of above-mentioned collection, 100 ℃ of heating in water bath 30 minutes obtain ginkgo episperm dry distillation stock solution.Quantitatively take by weighing above-mentioned ginkgo episperm dry distillation stock solution, add distilled water, making original liquid concentration is 60%, stirs into homogeneous mixture.Mixture packed into distill in the container that has agitating device, progressively heat up under stirring state, the control temperature is collected distillate, promptly between 105～115 ℃.
Get ginkgo episperm dry distillation rectification liquid 10%, add essence 0.3%, 6,501 5%, AESA15%, CAB-30 10%, and sodium chloride is an amount of, and adding distil water is to 1000ml, and mixing is made shampoo.
Claims (8)
1. the application of ginkgo episperm dry distillation liquid in the middle of the medicine of preparation treatment or prevention fungal disease.
2. the application of ginkgo episperm dry distillation liquid in the medicine of preparation treatment or prevention fungoid gynaecologic vaginal inflammation.
3. the application of ginkgo episperm dry distillation liquid in the medicine of preparation treatment or prevention fungal infection dermatoses.
4. a ginkgo episperm dry distillation liquid is in preparation treatment or the medicine of the prevention dandruff or the application in the hair washing product.
5. according to arbitrary described application among the claim 1-4, it is characterized in that employed ginkgo episperm dry distillation liquid made by following cracking process: get gingko episperm, put in the dry distilling container rectification liquid that the heating dry distilling obtains stock solution or continues to obtain after rectification.
6. application according to claim 5 is characterized in that described stock solution is made by following method: get gingko episperm, put in the dry distilling container, be heated to 90～120 ℃ and carry out dry distilling, steam is collected liquid through condensing tube condensation, discards; Improve heating-up temperature to 150～500 ℃ when no liquid flows out the back, be incubated 2～10 hours, continue dry distilling, steam is collected liquid through condensing tube condensation, flows out until no liquid, stops heating, lowers the temperature and removes the gred; With the liquid of above-mentioned collection, 80～100 ℃ of heating in water bath 30 minutes obtain ginkgo episperm dry distillation stock solution;
7. application according to claim 5, it is characterized in that described rectification liquid is made by following method: get the stock solution adding distil water, making original liquid concentration is 30%～80%, stirs into homogeneous mixture; Mixture packed into distill in the container that has agitating device, under stirring state, progressively heat up; The control temperature is collected distillate, promptly at 100-130 ℃.
8. according to arbitrary described application among the claim 1-4, it is characterized in that this application can be prepared into any in washing liquid, gel, suppository, spray, liniment, ointment, patch, vagina effervescence, tincture, the shampoo.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100999044A CN101502537A (en) | 2007-05-31 | 2007-05-31 | Application of ginkgo episperm dry distillation liquid in preparing medicament for treating or preventing fungal disease |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100999044A CN101502537A (en) | 2007-05-31 | 2007-05-31 | Application of ginkgo episperm dry distillation liquid in preparing medicament for treating or preventing fungal disease |
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| CN101502537A true CN101502537A (en) | 2009-08-12 |
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| CNA2007100999044A Pending CN101502537A (en) | 2007-05-31 | 2007-05-31 | Application of ginkgo episperm dry distillation liquid in preparing medicament for treating or preventing fungal disease |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247411A (en) * | 2011-08-18 | 2011-11-23 | 王青 | Application of ginkgo extractive in preparing external preparation capable of treating skin disease |
| CN102302524A (en) * | 2011-08-18 | 2012-01-04 | 王青 | Applications of gingko extractive in preparing external preparation for treating venereal disease, gynecopathy and perianal diseases |
| CN102319272A (en) * | 2011-08-18 | 2012-01-18 | 王青 | The purposes of gingkolic acid in the dermopathic external preparation of preparation treatment |
-
2007
- 2007-05-31 CN CNA2007100999044A patent/CN101502537A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247411A (en) * | 2011-08-18 | 2011-11-23 | 王青 | Application of ginkgo extractive in preparing external preparation capable of treating skin disease |
| CN102302524A (en) * | 2011-08-18 | 2012-01-04 | 王青 | Applications of gingko extractive in preparing external preparation for treating venereal disease, gynecopathy and perianal diseases |
| CN102319272A (en) * | 2011-08-18 | 2012-01-18 | 王青 | The purposes of gingkolic acid in the dermopathic external preparation of preparation treatment |
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Open date: 20090812 |