CN107095302A - Cannabinoids mixture and its application in the food industry - Google Patents
Cannabinoids mixture and its application in the food industry Download PDFInfo
- Publication number
- CN107095302A CN107095302A CN201710319752.8A CN201710319752A CN107095302A CN 107095302 A CN107095302 A CN 107095302A CN 201710319752 A CN201710319752 A CN 201710319752A CN 107095302 A CN107095302 A CN 107095302A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- mixture
- cannabinoids
- raw material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 101
- 229930003827 cannabinoid Natural products 0.000 title claims abstract description 76
- 239000003557 cannabinoid Substances 0.000 title claims abstract description 76
- 229940065144 cannabinoids Drugs 0.000 title claims abstract description 76
- 235000013305 food Nutrition 0.000 title claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 50
- 235000019219 chocolate Nutrition 0.000 claims abstract description 42
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 claims abstract description 19
- 238000002360 preparation method Methods 0.000 claims abstract description 19
- VBGLYOIFKLUMQG-UHFFFAOYSA-N Cannabinol Chemical compound C1=C(C)C=C2C3=C(O)C=C(CCCCC)C=C3OC(C)(C)C2=C1 VBGLYOIFKLUMQG-UHFFFAOYSA-N 0.000 claims abstract description 11
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 claims abstract description 10
- 229960003453 cannabinol Drugs 0.000 claims abstract description 10
- UVOLYTDXHDXWJU-UHFFFAOYSA-N Cannabichromene Chemical compound C1=CC(C)(CCC=C(C)C)OC2=CC(CCCCC)=CC(O)=C21 UVOLYTDXHDXWJU-UHFFFAOYSA-N 0.000 claims abstract description 9
- UVOLYTDXHDXWJU-NRFANRHFSA-N Cannabichromene Natural products C1=C[C@](C)(CCC=C(C)C)OC2=CC(CCCCC)=CC(O)=C21 UVOLYTDXHDXWJU-NRFANRHFSA-N 0.000 claims abstract description 9
- ORKZJYDOERTGKY-UHFFFAOYSA-N Dihydrocannabichromen Natural products C1CC(C)(CCC=C(C)C)OC2=CC(CCCCC)=CC(O)=C21 ORKZJYDOERTGKY-UHFFFAOYSA-N 0.000 claims abstract description 9
- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229950011318 cannabidiol Drugs 0.000 claims abstract description 9
- QXACEHWTBCFNSA-SFQUDFHCSA-N cannabigerol Chemical compound CCCCCC1=CC(O)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1 QXACEHWTBCFNSA-SFQUDFHCSA-N 0.000 claims abstract description 9
- QXACEHWTBCFNSA-UHFFFAOYSA-N cannabigerol Natural products CCCCCC1=CC(O)=C(CC=C(C)CCC=C(C)C)C(O)=C1 QXACEHWTBCFNSA-UHFFFAOYSA-N 0.000 claims abstract description 9
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 claims abstract description 9
- 235000013373 food additive Nutrition 0.000 claims abstract description 3
- 239000002778 food additive Substances 0.000 claims abstract description 3
- 244000299461 Theobroma cacao Species 0.000 claims description 48
- 239000000047 product Substances 0.000 claims description 48
- 238000001035 drying Methods 0.000 claims description 38
- 238000001256 steam distillation Methods 0.000 claims description 36
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 32
- 238000000605 extraction Methods 0.000 claims description 30
- 244000025254 Cannabis sativa Species 0.000 claims description 25
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 claims description 24
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 claims description 24
- 235000009120 camo Nutrition 0.000 claims description 24
- 235000005607 chanvre indien Nutrition 0.000 claims description 24
- 239000011487 hemp Substances 0.000 claims description 24
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000001569 carbon dioxide Substances 0.000 claims description 16
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 16
- 238000004140 cleaning Methods 0.000 claims description 16
- 239000000706 filtrate Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- 230000008859 change Effects 0.000 claims description 14
- 238000010792 warming Methods 0.000 claims description 14
- 238000001816 cooling Methods 0.000 claims description 13
- 239000000284 extract Substances 0.000 claims description 13
- 239000012530 fluid Substances 0.000 claims description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 235000009470 Theobroma cacao Nutrition 0.000 claims description 9
- 244000050510 Cunninghamia lanceolata Species 0.000 claims description 8
- 244000246386 Mentha pulegium Species 0.000 claims description 8
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 8
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 8
- 235000011347 Moringa oleifera Nutrition 0.000 claims description 8
- 235000001050 hortel pimenta Nutrition 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 239000011780 sodium chloride Substances 0.000 claims description 7
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- 229940110456 cocoa butter Drugs 0.000 claims description 4
- 235000019868 cocoa butter Nutrition 0.000 claims description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 244000179886 Moringa oleifera Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 13
- 230000008901 benefit Effects 0.000 abstract description 8
- 208000019901 Anxiety disease Diseases 0.000 abstract description 5
- 230000036506 anxiety Effects 0.000 abstract description 5
- 230000002218 hypoglycaemic effect Effects 0.000 abstract description 5
- 230000009467 reduction Effects 0.000 abstract description 5
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 4
- 230000001093 anti-cancer Effects 0.000 abstract description 4
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 4
- 239000003963 antioxidant agent Substances 0.000 abstract description 4
- 230000003078 antioxidant effect Effects 0.000 abstract description 4
- 235000006708 antioxidants Nutrition 0.000 abstract description 4
- 210000003205 muscle Anatomy 0.000 abstract description 4
- 210000000653 nervous system Anatomy 0.000 abstract description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 241000220215 Moringa Species 0.000 description 7
- 238000002835 absorbance Methods 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 238000009413 insulation Methods 0.000 description 6
- 239000012488 sample solution Substances 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 239000001856 Ethyl cellulose Substances 0.000 description 4
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 4
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 4
- 229920001249 ethyl cellulose Polymers 0.000 description 4
- 235000019325 ethyl cellulose Nutrition 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- -1 hydroxyl free radical Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 240000004308 marijuana Species 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000002000 scavenging effect Effects 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 description 1
- 102000018208 Cannabinoid Receptor Human genes 0.000 description 1
- 108050007331 Cannabinoid receptor Proteins 0.000 description 1
- 241000218231 Moraceae Species 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 229960002632 acarbose Drugs 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000011790 ferrous sulphate Substances 0.000 description 1
- 235000003891 ferrous sulphate Nutrition 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- 239000008236 heating water Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229940023569 palmate Drugs 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
- A23G1/42—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
- A23G1/48—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Application the present invention relates to a kind of Cannabinoids mixture and its in the food industry, the raw material components of Cannabinoids mixture by weight, including：The parts by weight of cannabidiol 10~20, the parts by weight of cannabigerol 5~10, the parts by weight of cannabinol 1~3 and the parts by weight of cannabichromene 2~5.The Cannabinoids mixture that the present invention is provided can be efficiently applied in food and/or food additives, especially applied in the preparation process of chocolate：By Cannabinoids mixture and chocolate raw material according to (0.01~2)：100.The Cannabinoids mixture that the present invention is prepared has many advantages, such as：Instant, possess anxiety reduction, relax one's muscles, protect nervous system, mitigate rheumatoid arthritis, anti-inflammatory, slow down pain, anticancer, sleeping and it is hypoglycemic the effects such as；And chocolate can be made to produce anti-oxidant, antibacterial effect, so as to be easier to preserve.
Description
Technical field
The present invention relates to food technology field, and in particular to a kind of Cannabinoids mixture and its in the food industry should
With.
Background technology
Hemp, Moraceae, Cannabis plant, annual upright draft is high 1~3 meter；Branch tool longitudinal furrow groove, close raw canescence patch
Lie prostrate hair.Leaf palmate is totally cleaved, sliver lanceolar or wire lanceolar, refers in particular to female through dry flower and trichome.Hemp kind
Plant peelable fiber crops and receive son, its main effectively chemical analysis is THC (abbreviation THC), THC spiritednesses after sucking or be oral
With physiological active function.The history that the mankind smoke cannabis is up to over thousands of year, and use of 20th century in terms of drugs and religion has
Increase tendency.For hemp this most ancient and purposes most wide planting plants, find now it can be used as medicine, cosmetics and
The source of industrial products.The cannboid and other medicines that act on mammalian cannabinoid receptor are currently explored to different diseases
The treatment of disease, the illness such as chronic ache, multiple sclerosis and epilepsy.
According to general international standard, hemp is classified according to THC (THC) percentage composition height, THC contents
Kind less than 0.3% is referred to as industrial hemp, is referred to as medicinal and marijuana hemp higher than 0.3%.All the time, industrial hemp exists
The fields such as weaving, papermaking, medicine, health, daily use chemicals, leather, automobile, building, decoration, packaging are able to extensive use, there is huge
Development space, can be rated as the production material of classics, already becomes the new focus of the competitive industry of China.
Based on this, the active principle in hemp how is effectively extracted, by its use legitimate to give full play to hemp
Value is particularly important.
The content of the invention
For defect of the prior art, the present invention is intended to provide a kind of Cannabinoids mixture and its in the food industry
Application.The Cannabinoids mixture that the present invention is prepared has many benefits to human body as a kind of natural extract, by it
The chocolate prepared applied to food industry and especially has the following advantages that：Instant, in several times of former chocolate
It is functionally set additionally to possess anxiety reduction, relax one's muscles, protect nervous system, mitigate rheumatoid arthritis, anti-inflammatory, slow down
Pain, anticancer, sleeping and it is hypoglycemic the effects such as；And chocolate can be made to produce anti-oxidant, antibacterial effect, so as to be easier to
Preserve.
Therefore, the present invention provides following technical scheme：
In a first aspect, the present invention provides a kind of Cannabinoids mixture, raw material components by weight, including：Hemp two
The parts by weight of phenol 10~20, the parts by weight of cannabigerol 5~10, the parts by weight of cannabinol 1~3 and the parts by weight of cannabichromene 2~5.Its
In, No. CAS of cannabidiol be 13956-29-1, No. CAS of cannabinol be 521-35-7.
In the further embodiment of the present invention, including：The parts by weight of cannabidiol 12~16, the weight of cannabigerol 7~9
Part, the parts by weight of cannabinol 2~3 and the parts by weight of cannabichromene 3~5.
Second aspect, application of the Cannabinoids mixture that the present invention is provided in food and/or food additives.Example
Such as, the Cannabinoids mixture present invention provided makes an addition in the preparation process of biscuit, candy, beverage etc. and is possible.
The third aspect, application of the Cannabinoids mixture that the present invention is provided in chocolate, by Cannabinoids mixture
With chocolate raw material according to (0.01~2)：100；Wherein, chocolate raw material is included in cocoa liquor, cocoa power and cocoa butter
It is one or more.
Fourth aspect, the present invention provides a kind of preparation method of Cannabinoids mixture, comprises the following steps：S101：Will
Raw material hemp cleaning, dry after shred, using supercritical carbon dioxide carry out first extract；S102：The product that S101 is obtained
Microwave drying is carried out, the first mixture is added afterwards and is stirred；S103：Product after stirring is adjusted to pH value simultaneously
Second is carried out using steam distillation to extract, and is filtered and is collected filtrate；S104：The filtrate microwave drying that S103 is obtained, it
After obtain Cannabinoids mixture.It should be noted that the raw material hemp in the present invention selects industrial hemp, and applicant is through inspection
Survey and find：THC is free of in the Cannabinoids mixture that the method provided using the present invention is prepared.
In the further embodiment of the present invention, in S101, cleaning is specially：Cleaned using cleaning fluid, and clearly
The raw material components of washing lotion by weight, including：The parts by weight of water 100~200, the parts by weight of hydroxyethyl cellulose 5~8, citric acid 2
~5 parts by weight and the parts by weight of sodium chloride 10~15；In S101, added in the first extraction and carry agent, carry agent and raw material hemp
Mass ratio is (3~5)：100；And it is 1 to carry agent to include mass ratio：The ethanol and sodium acid carbonate of (3~5).
In the further embodiment of the present invention, in S101, the first temperature extracted is 46 DEG C~48 DEG C, and pressure is
15.50MPa~17.30MPa, the time is 200min~500min, and the flow velocity of supercritical carbon dioxide is 15kg/h~20kg/h.
In the further embodiment of the present invention, in S102, the addition quality of the first mixture is production after microwave drying
0.05~0.1 times of amount of substance, and the first mixture raw material components by weight, including：The parts by weight of bay 3~5, peppermint
5~8 parts by weight, the silver-colored parts by weight of China fir 2~3, the parts by weight of leaf of Moringa 1~2 and the parts by weight of water 20~30.
In the further embodiment of the present invention, in S102 and S104, microwave drying is specially：Vacuum is
0.07MPa~0.09MPa, temperature change is：55 DEG C~60 DEG C are warming up to 1~2 DEG C of heating rate, insulation 80min~
100min；Afterwards 3 DEG C~5 DEG C are cooled to 5~8 DEG C of cooling rate.
In the further embodiment of the present invention, in S103, regulation to pH value and carries out the using steam distillation
Two extractions specifically include following steps：S201：It is 6.3~6.5 that product after stirring, which is adjusted to pH value, afterwards using water
Steam distillation method extracts 100min~200min；S202：It is 7.6~7.8 that the obtained products of S201, which are adjusted to pH value, is adopted afterwards
With extraction by steam distillation 30min~80min；S203：It is 6.8~7.1 that the obtained products of S202, which are adjusted to pH value, afterwards
Using extraction by steam distillation 90min~150min.
The above-mentioned technical proposal of the present invention has advantages below compared with prior art：
(1) applicant has found by numerous studies：The Cannabinoids mixture that the present invention is prepared is as a kind of natural
Extract has many benefits to human body, and the chocolate for being applied to food industry and especially preparing has following excellent
Point：Instant, several times of former chocolate functionally make its additionally possess anxiety reduction, relax one's muscles, protect nervous system,
Mitigate rheumatoid arthritis, anti-inflammatory, slow down pain, anticancer, sleeping and it is hypoglycemic the effects such as；And chocolate can be produced
Anti-oxidant, antibacterial effect, so as to be easier to preserve.
(2) it is well known that connection in developing rapidly with economic civilization in recent years, individual protector for collar domain between diet and health care
System has become more and more close.It is not only beneficial to spirit and the present invention provides and eats chocolate together with Cannabinoids compounding,
And there is positive meaning to healthy.Fast, the big crowd of operating pressure especially for rhythm of life in city, can be with
The aromatic delicious food that chocolate can be enjoyed by making people can also obtain physiology and psychological double treatment.
(3) the Cannabinoids mixture instant that the present invention is provided, the industrial hemp of traditional mixture containing Cannabinoids,
Take still more inconvenient daily, occur more in the form of pill, medicament, Chinese herbal medicine, it is necessary to use water delivery service or decoction,
This takes mode very complicated, and user is difficult to adhere to taking, so that impact effect；And the scheme that the present invention is provided effectively is solved
The defect for traditional Cannabinoids mixture inconvenient eating of having determined.
(4) the preparation method process stabilizing for the Cannabinoids mixture that the present invention is provided, yield are high, quality is good, energy consumption is low,
Raw material are extensive, process is simply saved；Production can be completed using existing equipment, equipment requirement is reduced, it is dirty to environment zero
Dye；And the preparation method provided using the present invention, it can effectively obtain final required Cannabinoids mixture.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
The embodiment to technical solution of the present invention is described in detail below.Following examples are only used for clearer
Explanation technical scheme, therefore be only used as example, and can not be limited the scope of the invention with this.
Experimental method in following embodiments, is conventional method unless otherwise specified.
Test material used, is to be commercially available from conventional reagent shop unless otherwise specified in following embodiments.
Quantitative test in following examples, is respectively provided with three repetition experiments, and data are the average value of three repetition experiments
Or mean+SD.
The present invention provides a kind of Cannabinoids mixture, raw material components by weight, including：The weight of cannabidiol 10~20
Measure part, the parts by weight of cannabigerol 5~10, the parts by weight of cannabinol 1~3 and the parts by weight of cannabichromene 2~5.
In addition, the present invention provides a kind of method that Cannabinoids mixture is used in prepared by chocolate：By Cannabinoids
Mixture is with chocolate raw material according to (0.01~2)：100；Wherein, chocolate raw material includes cocoa liquor, cocoa power and cocoa
One or more in fat.
In addition, for the Cannabinoids mixture of the present invention, can be by directly buying in above-mentioned Cannabinoids mixture
Each raw material components, be then mixed uniform, you can obtain Cannabinoids mixture；It can also be provided down using the present invention
The method of stating is prepared.
The present invention provides a kind of preparation method of Cannabinoids mixture, comprises the following steps：
S101：Shredded after raw material hemp is cleaned, dried, carrying out first using supercritical carbon dioxide extracts.Wherein, clearly
Wash specially：Cleaned using cleaning fluid, and cleaning fluid raw material components by weight, including：The weight of water 100~200
Part, the parts by weight of hydroxyethyl cellulose 5~8, the parts by weight of citric acid 2~5 and the parts by weight of sodium chloride 10~15；Added in first extraction
Agent is carried, the mass ratio for carrying agent and raw material hemp is (3~5)：100；And it is 1 to carry agent to include mass ratio：The second of (3~5)
Alcohol and sodium acid carbonate；First temperature extracted is 46 DEG C~48 DEG C, and pressure is 15.50MPa~17.30MPa, and the time is 200min
~500min, the flow velocity of supercritical carbon dioxide is 15kg/h~20kg/h.
S102：The product that S101 is obtained carries out microwave drying, and the first mixture is added afterwards and is stirred.Wherein,
The addition quality of first mixture is 0.05~0.1 times of product quality after microwave drying, and the raw material components of the first mixture
By weight, including：The parts by weight of bay 3~5, the parts by weight of peppermint 5~8, the silver-colored parts by weight of China fir 2~3, the parts by weight of leaf of Moringa 1~2
And the parts by weight of water 20~30.Microwave drying is specially：Vacuum is 0.07MPa~0.09MPa, and temperature change is：With 1~2
DEG C heating rate be warming up to 55 DEG C~60 DEG C, be incubated 80min~100min；Afterwards 3 are cooled to 5~8 DEG C of cooling rate
DEG C~5 DEG C.
S103：Product after stirring is adjusted to pH value and carries out second using steam distillation and is extracted, filtering
And collect filtrate.Wherein, regulation to pH value and specifically includes following steps using the extraction of steam distillation progress second：
S201：By the product after stirring adjust to pH value be 6.3~6.5, afterwards using extraction by steam distillation 100min~
200min；S202：It is 7.6~7.8 that the obtained products of S201, which are adjusted to pH value, afterwards using extraction by steam distillation
30min~80min；S203：It is 6.8~7.1 that the obtained products of S202, which are adjusted to pH value, is carried afterwards using steam distillation
Take 90min~150min.
S104：The filtrate microwave drying that S103 is obtained, obtains Cannabinoids mixture afterwards.Wherein, microwave drying has
Body is：Vacuum is 0.07MPa~0.09MPa, and temperature change is：55 DEG C~60 DEG C are warming up to 1~2 DEG C of heating rate,
It is incubated 80min~100min；Afterwards 3 DEG C~5 DEG C are cooled to 5~8 DEG C of cooling rate.
Illustrated with reference to embodiment：
Embodiment one
The present invention provides a kind of Cannabinoids mixture, raw material components by weight, including：The weight of cannabidiol 10
Part, the parts by weight of cannabigerol 5, the parts by weight of cannabinol 3 and the parts by weight of cannabichromene 2；Above-mentioned each raw material components are well mixed,
Obtain Cannabinoids mixture.
Embodiment two
The present invention provides a kind of Cannabinoids mixture, raw material components by weight, including：The weight of cannabidiol 20
Part, the parts by weight of cannabigerol 10, the parts by weight of cannabinol 1 and the parts by weight of cannabichromene 5；Above-mentioned each raw material components are mixed equal
It is even, obtain Cannabinoids mixture.
Embodiment three
The present invention provides a kind of Cannabinoids mixture, raw material components by weight, including：The weight of cannabidiol 15
Part, the parts by weight of cannabigerol 8, the parts by weight of cannabinol 2 and the parts by weight of cannabichromene 3；Above-mentioned each raw material components are well mixed,
Obtain Cannabinoids mixture.
In addition, also specifically there is implementation below in the preparation method of the Cannabinoids mixture provided according to the present invention：
Example IV
The present invention provides a kind of preparation method of Cannabinoids mixture, comprises the following steps：
S101：Shredded after raw material hemp is cleaned, dried, carrying out first using supercritical carbon dioxide extracts.Wherein, clearly
Wash specially：Cleaned using cleaning fluid, and cleaning fluid raw material components by weight, including：The parts by weight of water 200, hydroxyl
The parts by weight of ethyl cellulose 8, the parts by weight of citric acid 5 and the parts by weight of sodium chloride 15；First temperature extracted is 48 DEG C, and pressure is
15.50MPa, the time is 200min, and the flow velocity of supercritical carbon dioxide is 20kg/h.
S102：The product that S101 is obtained carries out microwave drying, and the first mixture is added afterwards and is stirred.Wherein,
Microwave drying is specially：Vacuum is 0.07MPa, and temperature change is：60 DEG C, insulation are warming up to 1 DEG C of heating rate
80min；Afterwards 3 DEG C are cooled to 5 DEG C of cooling rate.The addition quality of first mixture is product quality after microwave drying
0.05 times, and the first mixture raw material components by weight, including：The parts by weight of bay 5, the parts by weight of peppermint 5, the silver-colored weight of China fir 3
Measure part, the parts by weight of leaf of Moringa 1 and the parts by weight of water 30.
S103：Product after stirring is adjusted to pH value and carries out second using steam distillation and is extracted, filtering
And collect filtrate.Wherein, regulation to pH value and specifically includes following steps using the extraction of steam distillation progress second：
S201：It is 6.5 that product after stirring, which is adjusted to pH value, afterwards using extraction by steam distillation 100min；S202：Will
It is 7.6 that the product that S201 is obtained, which is adjusted to pH value, afterwards using extraction by steam distillation 80min；S203：S202 is obtained
It is 6.8 that product, which is adjusted to pH value, afterwards using extraction by steam distillation 150min.
S104：The filtrate microwave drying that S103 is obtained, obtains Cannabinoids mixture afterwards.Wherein, microwave drying has
Body is：Vacuum is 0.07MPa, and temperature change is：60 DEG C are warming up to 1 DEG C of heating rate, 80min is incubated；Afterwards with 5 DEG C
Cooling rate be cooled to 3 DEG C.
Embodiment five
The present invention provides a kind of preparation method of Cannabinoids mixture, comprises the following steps：
S101：Shredded after raw material hemp is cleaned, dried, carrying out first using supercritical carbon dioxide extracts.Wherein, clearly
Wash specially：Cleaned using cleaning fluid, and cleaning fluid raw material components by weight, including：The parts by weight of water 100, hydroxyl
The parts by weight of ethyl cellulose 5, the parts by weight of citric acid 2 and the parts by weight of sodium chloride 10；First temperature extracted is 46 DEG C, and pressure is
17.30MPa, the time is 500min, and the flow velocity of supercritical carbon dioxide is 15kg/h.
S102：The product that S101 is obtained carries out microwave drying, and the first mixture is added afterwards and is stirred.Wherein,
Microwave drying is specially：Vacuum is 0.09MPa, and temperature change is：55 DEG C, insulation are warming up to 2 DEG C of heating rate
100min；Afterwards 5 DEG C are cooled to 8 DEG C of cooling rate.The addition quality of first mixture is product quality after microwave drying
0.1 times, and the first mixture raw material components by weight, including：The parts by weight of bay 3, the parts by weight of peppermint 8, the silver-colored weight of China fir 2
Measure part, the parts by weight of leaf of Moringa 2 and the parts by weight of water 20.
S103：Product after stirring is adjusted to pH value and carries out second using steam distillation and is extracted, filtering
And collect filtrate.Wherein, regulation to pH value and specifically includes following steps using the extraction of steam distillation progress second：
S201：It is 6.3 that product after stirring, which is adjusted to pH value, afterwards using extraction by steam distillation 200min；S202：Will
It is 7.8 that the product that S201 is obtained, which is adjusted to pH value, afterwards using extraction by steam distillation 30min；S203：S202 is obtained
It is 7.1 that product, which is adjusted to pH value, afterwards using extraction by steam distillation 90min.
S104：The filtrate microwave drying that S103 is obtained, obtains Cannabinoids mixture afterwards.Wherein, microwave drying has
Body is：Vacuum is 0.09MPa, and temperature change is：55 DEG C are warming up to 2 DEG C of heating rate, 100min is incubated；Afterwards with 8
DEG C cooling rate be cooled to 5 DEG C.
Embodiment six
The present embodiment changes relevant parameter on the basis of embodiment five.
The present invention provides a kind of preparation method of Cannabinoids mixture, comprises the following steps：
S101：Shredded after raw material hemp is cleaned, dried, carrying out first using supercritical carbon dioxide extracts.Wherein, clearly
Wash specially：Cleaned using cleaning fluid, and cleaning fluid raw material components by weight, including：The parts by weight of water 100, hydroxyl
The parts by weight of ethyl cellulose 5, the parts by weight of citric acid 2 and the parts by weight of sodium chloride 10；First temperature extracted is 46 DEG C, and pressure is
17.30MPa, the time is 500min, and the flow velocity of supercritical carbon dioxide is 15kg/h；Added in first extraction and carry agent, carried
The mass ratio of agent and raw material hemp is 4：100；And it is 1 to carry agent to include mass ratio：3 ethanol and sodium acid carbonate.
S102：The product that S101 is obtained carries out microwave drying, and the first mixture is added afterwards and is stirred.Wherein,
Microwave drying is specially：Vacuum is 0.09MPa, and temperature change is：55 DEG C, insulation are warming up to 2 DEG C of heating rate
100min；Afterwards 5 DEG C are cooled to 8 DEG C of cooling rate.The addition quality of first mixture is product quality after microwave drying
0.1 times, and the first mixture raw material components by weight, including：The parts by weight of bay 3, the parts by weight of peppermint 8, the silver-colored weight of China fir 2
Measure part, the parts by weight of leaf of Moringa 2 and the parts by weight of water 20.
S103：Product after stirring is adjusted to pH value and carries out second using steam distillation and is extracted, filtering
And collect filtrate.Wherein, regulation to pH value and specifically includes following steps using the extraction of steam distillation progress second：
S201：It is 6.3 that product after stirring, which is adjusted to pH value, afterwards using extraction by steam distillation 200min；S202：Will
It is 7.8 that the product that S201 is obtained, which is adjusted to pH value, afterwards using extraction by steam distillation 30min；S203：S202 is obtained
It is 7.1 that product, which is adjusted to pH value, afterwards using extraction by steam distillation 90min.
S104：The filtrate microwave drying that S103 is obtained, obtains Cannabinoids mixture afterwards.Wherein, microwave drying has
Body is：Vacuum is 0.09MPa, and temperature change is：55 DEG C are warming up to 2 DEG C of heating rate, 100min is incubated；Afterwards with 8
DEG C cooling rate be cooled to 5 DEG C.
Embodiment seven
The present embodiment changes relevant parameter on the basis of embodiment five.
The present invention provides a kind of preparation method of Cannabinoids mixture, comprises the following steps：
S101：Shredded after raw material hemp is cleaned, dried, carrying out first using supercritical carbon dioxide extracts.Wherein, clearly
Wash specially：Cleaned using cleaning fluid, and cleaning fluid raw material components by weight, including：The parts by weight of water 100, hydroxyl
The parts by weight of ethyl cellulose 5, the parts by weight of citric acid 2 and the parts by weight of sodium chloride 10；First temperature extracted is 46 DEG C, and pressure is
17.30MPa, the time is 500min, and the flow velocity of supercritical carbon dioxide is 15kg/h.
S102：The product that S101 is obtained carries out microwave drying, and the first mixture is added afterwards and is stirred.Wherein,
Microwave drying is specially：Vacuum is 0.09MPa, and temperature change is：55 DEG C, insulation are warming up to 2 DEG C of heating rate
100min；Afterwards 5 DEG C are cooled to 8 DEG C of cooling rate.The addition quality of first mixture is product quality after microwave drying
0.1 times, and the first mixture raw material components by weight, including：The parts by weight of bay 3, the parts by weight of peppermint 8, the silver-colored weight of China fir 2
Measure part, the parts by weight of leaf of Moringa 2 and the parts by weight of water 20.
S103：It is 7.1 that product after stirring, which is adjusted to pH value, and carrying out second using steam distillation extracts
320min, filters and collects filtrate.
S104：The filtrate microwave drying that S103 is obtained, obtains Cannabinoids mixture afterwards.Wherein, microwave drying has
Body is：Vacuum is 0.09MPa, and temperature change is：55 DEG C are warming up to 2 DEG C of heating rate, 100min is incubated；Afterwards with 8
DEG C cooling rate be cooled to 5 DEG C.
Embodiment eight
The present embodiment changes relevant parameter on the basis of embodiment five.
The present invention provides a kind of preparation method of Cannabinoids mixture, comprises the following steps：
S101：Shredded after raw material hemp is cleaned with water, dried, carrying out first using supercritical carbon dioxide extracts.Its
In, the first temperature extracted is 46 DEG C, and pressure is 17.30MPa, and the time is 500min, and the flow velocity of supercritical carbon dioxide is
15kg/h。
S102：The product that S101 is obtained carries out microwave drying, and the first mixture is added afterwards and is stirred.Wherein,
Microwave drying is specially：Vacuum is 0.09MPa, and temperature change is：55 DEG C, insulation are warming up to 2 DEG C of heating rate
100min；Afterwards 5 DEG C are cooled to 8 DEG C of cooling rate.The addition quality of first mixture is product quality after microwave drying
0.1 times, and the first mixture raw material components by weight, including：The parts by weight of bay 3, the parts by weight of peppermint 8, the silver-colored weight of China fir 2
Measure part, the parts by weight of leaf of Moringa 2 and the parts by weight of water 20.
S103：Product after stirring is adjusted to pH value and carries out second using steam distillation and is extracted, filtering
And collect filtrate.Wherein, regulation to pH value and specifically includes following steps using the extraction of steam distillation progress second：
S201：It is 6.3 that product after stirring, which is adjusted to pH value, afterwards using extraction by steam distillation 200min；S202：Will
It is 7.8 that the product that S201 is obtained, which is adjusted to pH value, afterwards using extraction by steam distillation 30min；S203：S202 is obtained
It is 7.1 that product, which is adjusted to pH value, afterwards using extraction by steam distillation 90min.
S104：The filtrate microwave drying that S103 is obtained, obtains Cannabinoids mixture afterwards.Wherein, microwave drying has
Body is：Vacuum is 0.09MPa, and temperature change is：55 DEG C are warming up to 2 DEG C of heating rate, 100min is incubated；Afterwards with 8
DEG C cooling rate be cooled to 5 DEG C.
In addition, the Cannabinoids mixture that embodiment one to embodiment eight is prepared is applied to the application of chocolate
In：By Cannabinoids mixture and chocolate raw material according to 0.2：100 mass ratio mixing；Wherein, chocolate raw material include can
One or more that can be in liquid block, cocoa power and cocoa butter.
Specifically：Each component is weighed according to following ratio：Cocoa liquor 64.52%, cocoa butter 4.95%, sucrose
15.0%th, xylitol 15.0%, Cannabinoids mixture 0.2%.Above component is placed in pulverizer and mixed, heating stirring
8.5 hours, it is poured into module, is cooled to room temperature, forms the chocolate that every piece of 5g is unit.It should be noted that：From it
He is possible at sweet substance such as saccharin, sucrose, white granulated sugar and xylitol etc..
In addition, effect in order to preferably evaluate the chocolate prepared using each embodiment Cannabinoids mixture,
Carry out following test：
First, the measure of each embodiment Cannabinoids mix ingredients
Specifically, Cannabinoids mix ingredients of the example IV into embodiment eight is detected using GC-MS methods, and will be each
Main component in embodiment is listed in table 1：
Each embodiment Cannabinoids mix ingredients list of table 1
2nd, the antioxidation of chocolate is prepared using each embodiment Cannabinoids mixture
(1) Scavenging activity on hydroxyl free radical is determined：0.75mmol/L Phen solution 1ml is taken in 10ml tool plug test tubes
In, 2ml0.2mmol/L is sequentially added, pH is 7.5 PBS, 1ml0.75mmol/L ferrous sulfate is well mixed, plus
Enter 1ml sample solutions, 1ml0.01% hydrogen peroxide is added after mixing, deionized water constant volume is used, 37 DEG C of heating water bath 60min,
Go out to determine its absorbance in 510nm.Clearance rate to hydroxy radical is calculated as follows：Clearance rate=[(A1-A0)/(A2-A0)]
× 100%；Wherein, A1To add absorbance when hydrogen peroxide and sample；A0For the suction for adding hydrogen peroxide but when being not added with sample
Luminosity；A2For hydrogen peroxide and the sample not absorbance of added-time.In addition, the collocation method of sample solution is：Take 5g's respectively
Each embodiment Cannabinoids mixture prepares chocolate in 8 beakers, adds 100ml deionized waters after 45 DEG C of microwaves
60min is heated, is cooled to and the required sample solution of the present invention is obtained after room temperature.
(2) measure of DPPH clearance rates：Each 2ml of above-mentioned sample solution is taken, the DPPH for adding 2ml 0.1mmol/L is molten
Liquid is well mixed, and after lucifuge reaction 30min, absorbance A1 is determined at 217nm；Blank group replaces sample solution with DPPH,
Control group replaces sample solution with isometric distilled water.Clearance rate is calculated as follows：Clearance rate=[1- (A1-A0)/A2]×
100%；Wherein, A1For the absorbance of sample sets；A0For the absorbance of blank group；A2For the absorbance of control group.Each embodiment
The specific experiment data of chocolate inoxidizability are as shown in table 2：
Each embodiment Cannabinoids mixture of table 2 prepares the antioxidation of chocolate
| Scavenging action to hydroxyl free radical/% | Measure/% of DPPH clearance rates | |
| Embodiment one | 89 | 90 |
| Embodiment two | 90 | 91 |
| Embodiment three | 89 | 90 |
| Example IV | 97 | 96 |
| Embodiment five | 97 | 95 |
| Embodiment six | 99 | 97 |
| Embodiment seven | 86 | 88 |
| Embodiment eight | 85 | 86 |
3rd, the calm stimulating effect of chocolate is prepared using each embodiment Cannabinoids mixture
The volunteer 900 (including middle school student, university student and white collar etc. of working overtime) of call-up age 15-45 Sui, each volunteer
The anxiety brought greatly with pressure to varying degrees with it is tired out；After the chocolate that the edible present invention is provided, this hair is evaluated
The calm effect of refreshing oneself of the chocolate of bright offer.Wherein, volunteer is divided equally 9 groups, every group of 100 people, the 1st group to the 8th group difference
Embodiment one is tried out to the chocolate 5g of embodiment eight；9th group is tried out commercially available chocolate 5g.Testing time is at 1 point in afternoon.Respectively
Questionnaire investigation is investigated respectively to edible rear 10min, 1h and 3h, with 5 personal calm effects of refreshing oneself felt of point-scores statistics
Really, subject answers a question according to oneself impression in itself.
The calm effect degree of refreshing oneself of product is divided into " highly effective ", " effective ", " a little imitating ", engineering noise and " not had completely
Effect ", gives 5 to 1 points, obatained score is bigger respectively, and the calm effect of refreshing oneself represented for product feels more satisfied, calm to refresh oneself
The statistical result of effect such as table 3.
Each embodiment Cannabinoids mixture of table 3 prepares the calm effect of refreshing oneself of chocolate
4th, the hypoglycemic effect of chocolate is prepared using each embodiment Cannabinoids mixture
(M-F is 1 to the call-up age diabetic of 30~80 years old 900:1)；Wherein, 30-50 Sui patient and
Each 450 of 50-80 Sui patient.The clinical symptoms of patient are shown as：Fasting blood sugar is higher than 7.0mmol/L, after the meal two hours
Blood glucose value is in the range of 9~12mmol/L.Specifically, two class volunteers are divided into 9 groups, i.e., every group includes 30-50 Sui
Patient 50 and 50~80 years old patient 50；By first group to the 8th group respectively with canteen with embodiment one into embodiment eight it is big
Numb element class mixture prepares chocolate, and each 5g is once a day, edible with breakfast；Control group is set to by the 9th group, just
Normal diet, and any medicine is not taken.The chocolate that there is provided of the continuous edible present invention 10 days, the sky of patient was measured at the 10th day
Abdomen blood glucose value and after the meal two hours blood glucose values.Specific data are as shown in table 4.It should be noted that provided in the edible present invention
During chocolate, other hypoglycemic drugs, such as Glucobay are taken in each patient's pause or reduction.
Table 4 continuously gives the product influence to blood sugar in diabetic patients value in 10 days of the present invention
Certainly, except the situation that embodiment one is enumerated to embodiment eight, the species and percentage by weight of other raw material components,
Condition and parameter in preparation process etc. are also possible.
The Cannabinoids mixture that the present invention is prepared has many benefits to human body as a kind of natural extract, by it
The chocolate prepared applied to food industry and especially has the following advantages that：Instant, in several times of former chocolate
It is functionally set additionally to possess anxiety reduction, relax one's muscles, protect nervous system, mitigate rheumatoid arthritis, anti-inflammatory, slow down
Pain, anticancer, sleeping and it is hypoglycemic the effects such as；And chocolate can be made to produce anti-oxidant, antibacterial effect, so as to be easier to
Preserve.
In the description of this specification, it is to be understood that reference term " one embodiment ", " some embodiments ", " show
The description of example ", " specific example " or " some examples " etc. mean to combine the specific features of the embodiment or example description, structure,
Material or feature are contained at least one embodiment of the present invention or example.In this manual, above-mentioned term is shown
The statement of meaning property is necessarily directed to identical embodiment or example.Moreover, specific features, structure, material or the spy of description
Point can in an appropriate manner be combined in any one or more embodiments or example.In addition, in the case of not conflicting,
Those skilled in the art can be by the not be the same as Example or example and non-be the same as Example described in this specification or example
Feature is combined and combined.
Although embodiments of the invention have been shown and described above, it is to be understood that above-described embodiment is example
Property, it is impossible to limitation of the present invention is interpreted as, one of ordinary skill in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, changed, replacing and modification.
Claims (10)
1. a kind of Cannabinoids mixture, it is characterised in that raw material components by weight, including：
The parts by weight of cannabidiol 10~20, the parts by weight of cannabigerol 5~10, the parts by weight of cannabinol 1~3 and cannabichromene 2~5
Parts by weight.
2. Cannabinoids mixture according to claim 1, it is characterised in that including：
The parts by weight of cannabidiol 12~16, the parts by weight of cannabigerol 7~9, the parts by weight of cannabinol 2~3 and cannabichromene 3~5
Parts by weight.
3. application of the Cannabinoids mixture in food and/or food additives described in claim 1 or 2.
4. application of the Cannabinoids mixture in chocolate described in claim 1 or 2, it is characterised in that：
By the Cannabinoids mixture and chocolate raw material according to (0.01~2)：100；
Wherein, the chocolate raw material includes the one or more in cocoa liquor, cocoa power and cocoa butter.
5. the preparation method of Cannabinoids mixture described in a kind of claim 1 or 2, it is characterised in that comprise the following steps：
S101：Shredded after raw material hemp is cleaned, dried, carrying out first using supercritical carbon dioxide extracts；
S102：The product that the S101 is obtained carries out microwave drying, and the first mixture is added afterwards and is stirred；
S103：Product after described stir is adjusted to pH value and carries out second using steam distillation and is extracted, afterwards
Filter and collect filtrate；
S104：The filtrate microwave drying that the S103 is obtained, obtains the Cannabinoids mixture afterwards.
6. the preparation method of Cannabinoids mixture according to claim 5, it is characterised in that：
In the S101, the cleaning is specially：Cleaned using cleaning fluid, and the cleaning fluid raw material components by weight
Part meter, including：The parts by weight of water 100~200, the parts by weight of hydroxyethyl cellulose 5~8, the parts by weight of citric acid 2~5 and sodium chloride 10
~15 parts by weight；
In the S101, added in first extraction and carry agent, the mass ratio of the carrying agent and the raw material hemp is (3
~5)：100；And it is 1 that the carrying agent, which includes mass ratio,：The ethanol and sodium acid carbonate of (3~5).
7. the preparation method of Cannabinoids mixture according to claim 5, it is characterised in that：
In the S101, the described first temperature extracted is 46 DEG C~48 DEG C, and pressure is 15.50MPa~17.30MPa, and the time is
200min~500min, the flow velocity of supercritical carbon dioxide is 15kg/h~20kg/h.
8. the preparation method of Cannabinoids mixture according to claim 5, it is characterised in that：
In the S102, the addition quality of first mixture is 0.05~0.1 times of product quality after the microwave drying,
And the raw material components of first mixture are by weight, including：The parts by weight of bay 3~5, the parts by weight of peppermint 5~8, silver-colored China fir 2
~3 parts by weight, the parts by weight of leaf of Moringa 1~2 and the parts by weight of water 20~30.
9. the preparation method of Cannabinoids mixture according to claim 5, it is characterised in that：
In the S102 and the S104, the microwave drying is specially：
Vacuum is 0.07MPa~0.09MPa, and temperature change is：55 DEG C~60 DEG C, guarantor are warming up to 1~2 DEG C of heating rate
Warm 80min~100min；Afterwards 3 DEG C~5 DEG C are cooled to 5~8 DEG C of cooling rate.
10. the preparation method of Cannabinoids mixture according to claim 5, it is characterised in that：
In the S103, regulation to pH value and specifically includes following steps using the extraction of steam distillation progress second：
S201：It is 6.3~6.5 that product after described stir, which is adjusted to pH value, afterwards using extraction by steam distillation
100min~200min；
S202：It is 7.6~7.8 that the obtained products of the S201, which are adjusted to pH value, afterwards using extraction by steam distillation
30min~80min；
S203：It is 6.8~7.1 that the obtained products of the S202, which are adjusted to pH value, afterwards using extraction by steam distillation
90min~150min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710319752.8A CN107095302A (en) | 2017-05-09 | 2017-05-09 | Cannabinoids mixture and its application in the food industry |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710319752.8A CN107095302A (en) | 2017-05-09 | 2017-05-09 | Cannabinoids mixture and its application in the food industry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107095302A true CN107095302A (en) | 2017-08-29 |
Family
ID=59668727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710319752.8A Pending CN107095302A (en) | 2017-05-09 | 2017-05-09 | Cannabinoids mixture and its application in the food industry |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107095302A (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108968071A (en) * | 2018-09-26 | 2018-12-11 | 江西中医药大学 | The application of bitter orange flower and fructus cannabis composition in preparation improvement failure of memory or medicament for treatment of depression or health functional beverage |
| WO2019057994A1 (en) * | 2017-09-25 | 2019-03-28 | Krotov Vadym | New composition and method for the preparation thereof |
| CN110448598A (en) * | 2019-08-09 | 2019-11-15 | 汉康生物科技(深圳)有限公司 | A kind of medical water-soluble cannabidiol CBD pharmaceutical formulation |
| CN110575432A (en) * | 2018-06-08 | 2019-12-17 | 汉义生物科技（北京）有限公司 | Composition containing cannabidiol and application of composition in animal products |
| US11040932B2 (en) | 2018-10-10 | 2021-06-22 | Treehouse Biotech, Inc. | Synthesis of cannabigerol |
| US11084770B2 (en) | 2016-12-07 | 2021-08-10 | Treehouse Biotech, Inc. | Cannabis extracts |
| CN113368086A (en) * | 2021-08-11 | 2021-09-10 | 龙麻(上海)医药研发有限责任公司 | Cannabinoid composition and its application in preparation of medicine for treating neurodegenerative diseases such as Parkinson and Alzheimer |
| CN113423280A (en) * | 2019-01-25 | 2021-09-21 | 诺狄更斯公司 | Cannabinoid chewing gum with sugar alcohol |
| US11202771B2 (en) | 2018-01-31 | 2021-12-21 | Treehouse Biotech, Inc. | Hemp powder |
| CN114761572A (en) * | 2019-08-27 | 2022-07-15 | 赫博利生物科技股份公司 | Cannabinoid concentrates and isolates, methods of obtaining the same, and uses thereof |
| AU2020268218B2 (en) * | 2019-05-03 | 2022-09-08 | Zyus Life Sciences Inc. | Formulation for pain management |
| EP3972419A4 (en) * | 2019-05-23 | 2023-01-04 | Canopy Growth Corporation | Method of making cocoa butter-derived products containing cannabinoids |
-
2017
- 2017-05-09 CN CN201710319752.8A patent/CN107095302A/en active Pending
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11084770B2 (en) | 2016-12-07 | 2021-08-10 | Treehouse Biotech, Inc. | Cannabis extracts |
| WO2019057994A1 (en) * | 2017-09-25 | 2019-03-28 | Krotov Vadym | New composition and method for the preparation thereof |
| US11202771B2 (en) | 2018-01-31 | 2021-12-21 | Treehouse Biotech, Inc. | Hemp powder |
| CN110575432B (en) * | 2018-06-08 | 2021-10-12 | 汉义生物科技（北京）有限公司 | Composition containing cannabidiol and application of composition in animal products |
| CN110575432A (en) * | 2018-06-08 | 2019-12-17 | 汉义生物科技（北京）有限公司 | Composition containing cannabidiol and application of composition in animal products |
| CN108968071A (en) * | 2018-09-26 | 2018-12-11 | 江西中医药大学 | The application of bitter orange flower and fructus cannabis composition in preparation improvement failure of memory or medicament for treatment of depression or health functional beverage |
| US11040932B2 (en) | 2018-10-10 | 2021-06-22 | Treehouse Biotech, Inc. | Synthesis of cannabigerol |
| CN113423280A (en) * | 2019-01-25 | 2021-09-21 | 诺狄更斯公司 | Cannabinoid chewing gum with sugar alcohol |
| AU2020268218B2 (en) * | 2019-05-03 | 2022-09-08 | Zyus Life Sciences Inc. | Formulation for pain management |
| US11963943B2 (en) | 2019-05-03 | 2024-04-23 | Zyus Life Sciences Inc. | Formulation for pain management |
| EP3972419A4 (en) * | 2019-05-23 | 2023-01-04 | Canopy Growth Corporation | Method of making cocoa butter-derived products containing cannabinoids |
| CN110448598A (en) * | 2019-08-09 | 2019-11-15 | 汉康生物科技(深圳)有限公司 | A kind of medical water-soluble cannabidiol CBD pharmaceutical formulation |
| CN114761572A (en) * | 2019-08-27 | 2022-07-15 | 赫博利生物科技股份公司 | Cannabinoid concentrates and isolates, methods of obtaining the same, and uses thereof |
| CN113368086A (en) * | 2021-08-11 | 2021-09-10 | 龙麻(上海)医药研发有限责任公司 | Cannabinoid composition and its application in preparation of medicine for treating neurodegenerative diseases such as Parkinson and Alzheimer |
| US11497719B1 (en) | 2021-08-11 | 2022-11-15 | Chendong Zou | Cannabinoid composition and application of the same in preparing medicine for treating neurodegenerative diseases including parkinson's disease and alzheimer's disease |
| WO2023015772A1 (en) * | 2021-08-11 | 2023-02-16 | 龙麻(上海)医药研发有限责任公司 | Cannabinoid composition and application thereof in preparation of drug for treating neurodegenerative diseases such as parkinson's disease and alzheimer's disease |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107095302A (en) | Cannabinoids mixture and its application in the food industry | |
| CN106333885A (en) | Plant extract and eye essence liquid | |
| CN101999468A (en) | Walnut milk beverage and preparation method thereof | |
| CN102634441B (en) | A kind of preparation method of health-care vinegar | |
| CN109329786A (en) | It is a kind of using astaxanthin egg as the manufacturing method of the extraordinary diet substrate of raw material | |
| CN104171774A (en) | Enzymolysis flavored golden pomelo paste and production method thereof | |
| CN103860431B (en) | A kind of tea oil ooze cold cream and processing method | |
| CN108991529A (en) | The food compositions and preparation method thereof of member are supported in a kind of invigorating the spleen | |
| CN104388236B (en) | A kind of grape wine and preparation method and application | |
| CN102021104B (en) | Papaya wine having health-care function on damp-heat physique and preparation method thereof | |
| CN103860432B (en) | A kind of tea oil Chinese yam cold cream and processing method | |
| CN107319222A (en) | A kind of Anshen Bunao gynostemma pentaphylla Chinese herbal health-caring beverage and preparation method thereof | |
| CN106962908A (en) | A kind of preparation method of antidepression rose enzyme | |
| CN105695236A (en) | Formula and production process for health maintenance and healthcare wine | |
| CN109939097A (en) | Compound is preparing the application in antiobesity agent, Bariatric agent and gene expression promotor | |
| CN102132880B (en) | Health-care food and preparation method thereof | |
| CN107997153A (en) | A kind of sealwort composite heal-care food and preparation method thereof | |
| CN108567914A (en) | It is a kind of that there is the Chinese medicine preparation and its preparation method and application for improving sleep effect | |
| CN107739684A (en) | A kind of chamomile wine and preparation method thereof | |
| CN108175825A (en) | For tonifying Qi of the kidney, pharmaceutical composition of invigorating the spleen moistening lung and preparation method thereof | |
| CN105055248B (en) | The anti-aging daily chemical products of application and its preparation of the Radix Polygalae total saponins in skin anti-aging daily chemical products are prepared | |
| CN104804924A (en) | Wild bee health preserving wine | |
| CN101502537A (en) | Application of ginkgo episperm dry distillation liquid in preparing medicament for treating or preventing fungal disease | |
| CN101773179B (en) | Health-caring tea for preventing cardiovascular and cerebrovascular diseases and preparation method thereof | |
| CN105039090A (en) | Wild pueraria lobata steaming liquor and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170829 |