CN102247411A - Application of ginkgo extractive in preparing external preparation capable of treating skin disease - Google Patents
Application of ginkgo extractive in preparing external preparation capable of treating skin disease Download PDFInfo
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Abstract
The invention relates to an application of ginkgo extractive in preparing external preparation capable of treating skin diseases. The ginkgo extractive can be obtained from extractives of ginkgo leaves, fruits, testa, roots, stems and other positions with a chemical separation method. Extraction solvents can be organic solvents, such as ethanol, water, aether, sherwood oil and the like. The skin disease is infectious, inflammatory, allergic reaction or allergic dermatitis. The drug, cosmetics or disinfector external preparations containing ginkgo extractives contains 0.001-80wt% of ginkgo extractive, pharmaceutically commonly-used external preparation or acceptable carrier. The preparation is any external preparation of pharmacy. The local irritation test researches to show that the ginkgo extractive is safe, is free from adverse reaction, such as skin irritation, allergy and the like. The trial result of patients with clinical infectious or anaphylactic skin diseases proves that the ginkgo extractive has obvious treating effect on various skin diseases, and the effective rate is 100%, and the ginkgo extractive is safe to use and has no side effect.
Description
Technical field
The invention belongs to biological medicine and therapeutic make-up technique field, be specifically related to the purposes of Semen Ginkgo extrac in the dermopathic external preparation of preparation treatment.
Background technology
Dermatosis is one of clinical modal disease.Because most dermatosis longer durations, easily outbreak repeatedly brings misery to the patient, has a strong impact on patient's physical and mental health.The common skin disease has struvite and allergic skin disease.Inflammatory skin disease (dermatitis) can be divided into infectious and non-infectious, and the infectious skin disease can be caused by antibacterial, virus, fungus and protozoon, as impetigo, folliculitis, acne, herpes, tinea manus and pedis, tinea corporis, acariasis, scabies etc.; Non-infectious dermatosis mostly is allergy or anaphylaxis dermatosis, as neurodermatitis, eczema, urticaria, miliaria, skin pruritus etc.The clinical manifestation of dermatitis has performances such as local skin is red, swollen, hot, pain, and allergy or anaphylaxis dermatosis clinical manifestation also have the symptom of dermatitis, and past contact is with pruritus.Therefore the above-mentioned dermopathic pathogeny part that communicates.Treatment infectious skin disease mostly is antimicrobial drug, antiviral agents or antifungal agent at present, and the medicine of treatment inflammatory and allergic skin disease mostly is corticosteroid hormone, though these medicines have effect for the moment, often occurs skin lesion after the drug withdrawal and worsens; And prolonged application can cause many side effect.For fear of the generation of this type of bad phenomenon, market demand develop a kind of derive from natural, effect significantly, the dermopathic external preparation of treatment of action range, no obvious adverse reaction, to alleviate the patient suffering.Dermatosis is of a great variety and the patient is numerous, and therefore develop this type of and treat dermopathic external preparation product and have good potential applicability in clinical practice, be very useful and necessary to the patient.
Semen Ginkgo is the medicinal plants of China's preciousness, and the leaf of Semen Ginkgo, fruit and episperm etc. all have medicinal exploitation and be worth.According to the Compendium of Material Medica record, Semen Ginkgo property is sweet, bitter, flat, puckery; Have that relieving asthma and cough, leukorrhagia stopping are turbid, the merit of pain relieving; Cure mainly cough of cold type phlegm dyspnea, asthma, frequent micturition, leucorrhea with red and white discharge, rhagadia manus et pedis etc.It is found that in recent decades particularly and contain plurality of active ingredients in the Folium Ginkgo that main effective ingredient is flavonoid and terpene lactone chemical compound, has the function of control cardiovascular and cerebrovascular disease.China has the gingko episperm soak is used as pesticide morning among the people, and insects such as aphid, rice borer are had killing action.Have not yet to see the report of the purposes of Semen Ginkgo extrac in the external preparation of preparation treatment inflammatory and allergic skin disease.Therefore, relevant Semen Ginkgo extrac external preparation is prevented and treated the research and development of dermatosis newtype drug, cosmetics, disinfectant, and to the abundant development and use of gingko resource, will produce huge social and economic benefit.
Summary of the invention
The new purposes that the purpose of this invention is to provide Semen Ginkgo extrac, the i.e. purposes of Semen Ginkgo extrac in the dermopathic external preparation of preparation control.It has the function of infectious, the struvite and allergic skin disease of control, has evident in efficacy, action range, characteristics safe in utilization.
The object of the present invention is achieved like this:
The purposes of Semen Ginkgo extrac in the treatment dermatosis is provided.
The purposes of Semen Ginkgo extrac in the dermopathic external preparation of preparation treatment is provided.
Described Semen Ginkgo extrac is by the Chemical Decomposition method, from the leaf of Semen Ginkgo, really, obtain the extract at positions such as episperm, rhizome, extracts solvent and can be organic solvents such as ethanol, water, ether, petroleum ether; Or to Folium Ginkgo, really, episperm, rhizome extract elaboration products and reclaim again in the remaining waste material in extracting the course of processing.
Described dermatosis is antibacterial, virus, fungus, parasite insect infection dermatoses; Described dermatosis is struvite, allergy, anaphylaxis dermatosis.
Further, described dermatosis is various skin diseases such as impetigo, folliculitis, herpes, wart, tinea, eczema, urticaria, skin pruritus, dermatitis, acariasis, scabies, tinea unguium, clavus callus, psoriasis.
The dermopathic medicine of the treatment that contains Semen Ginkgo extrac, cosmetics or disinfectant external preparation also are provided, contain Semen Ginkgo extrac 0.001-80%, by weight percentage, and external preparation substrate or external preparation acceptable carrier pharmaceutically commonly used.
Further, contain Semen Ginkgo extrac 0.001-30%, by weight percentage.
Further, contain Semen Ginkgo extrac 0.5-20%, by weight percentage.
By above-mentioned weight ratio scope get the principal agent Semen Ginkgo extrac, external preparation substrate or acceptable carrier pharmaceutically commonly used prepares the Semen Ginkgo extrac external preparation; And comprise Semen Ginkgo extrac and any combinations of substances is used for the treatment of dermopathic medicine, cosmetics or disinfectant external preparation.Described preparation is a said exterior-applied formulation on any pharmaceutics, can be liquid preparation, cream cream, gel, membrane, lotion, powder, aerosol spray, suppository, transdermal absorption formulation etc.; The pharmacological testing of line correlation and the clinic trial of going forward side by side test.
The invention has the beneficial effects as follows, Semen Ginkgo extrac external preparation of the present invention has significant therapeutical effect to infectious, struvite and anaphylaxis dermatosis, side effect due to the action range, and curative effect is better than glucocorticoid or antibiotic, no life-time service glucocorticoid, antibiotic.The local irritation experimentation shows safety of the present invention, untoward reaction such as no skin irritation, allergy.Clinical various skin patient's result on trial shows that the present invention has significant therapeutical effect to the various skin disease, and effective percentage reaches 100%, safe in utilization having no side effect.
The specific embodiment
Below in conjunction with embodiment, the present invention is done to describe further.
Embodiment 1:
The ginkgo nut episperm is stripped down, dry, it is pulverized with pulverizer.Accurately take by weighing a certain amount of gingko episperm through pulverizing, adding solid-liquid ratio is 80% ethanol of 1: 6 (W/V), under 60 ℃ of bath temperatures, and stirring and leaching 2 times, each 4 hours extraction times.Lixiviate is used the nutsch filter sucking filtration after finishing, and collects filtrate.With rotary evaporation in vacuo instrument concentrated filtrate, condition is 55 ℃ of temperature, pressure 0.008-0.009MPa, concentrating under reduced pressure.In 60 ℃ of vacuum dryings, get Semen Ginkgo extrac extractum, character is: light brown extractum, little smelly, be dissolved in alcohol, water insoluble.
The preparation of gel: carbopol 10g is sprinkled upon 500ml distilled water surface, and swelling is spent the night.Take by weighing glycerol 60g, propylene glycol 120ml is added to respectively in the good carbopol of swelling, grinds evenly rapidly, obtains transparent gel-type vehicle.Get above-mentioned Semen Ginkgo extrac extractum 40g, be dissolved in 100ml 95% alcoholic solution, slowly be added in the gel-type vehicle, stir.Slowly add triethanolamine 15ml again, mend distilled water to capacity 1000g, promptly get faint yellow Semen Ginkgo extrac gel 1000g, Semen Ginkgo extrac content is 4% (W/W).Be sub-packed in 50 tubules every 20g.
Embodiment 2:
The ginkgo nut episperm is stripped down, dry, it is pulverized with pulverizer.Accurately take by weighing a certain amount of gingko episperm through pulverizing, adding solid-liquid ratio is the distilled water of 1: 6 (W/V), under 60 ℃ of bath temperatures, and stirring and leaching 2 times, each 4 hours extraction times.Lixiviate is used the nutsch filter sucking filtration after finishing, and collects filtrate.Concentrated filtrate.In 60 ℃ of vacuum dryings, get Semen Ginkgo extrac extractum, character is: light brown extractum, little smelly, be dissolved in alcohol, water insoluble.
The preparation of ointment: get above-mentioned Semen Ginkgo extrac extractum 5g, be dissolved in 100ml 95% alcoholic solution, to wherein adding triethanolamine 50ml, heat again to 70 ℃.Paraffin 300g, stearic acid 300g, propylene glycol 100ml are added stirring respectively melt, mend distilled water to capacity 1000g, stir to paste, promptly get faint yellow Semen Ginkgo extrac ointment 1000g, Semen Ginkgo extrac content is 0.5% (W/W).Be sub-packed in 50 tubules every 20g.
Embodiment 3:
The ginkgo nut episperm is stripped down, dry, it is pulverized with pulverizer.Accurately take by weighing a certain amount of gingko episperm through pulverizing, adding solid-liquid ratio is 80% petroleum ether of 1: 6 (W/V), under 60 ℃ of bath temperatures, and stirring and leaching 2 times, each 4 hours extraction times.Lixiviate is used the nutsch filter sucking filtration after finishing, and collects filtrate.With rotary evaporation in vacuo instrument concentrated filtrate, condition is 55 ℃ of temperature, pressure 0.008-0.009MPa, concentrating under reduced pressure.In 60 ℃ of vacuum dryings, get Semen Ginkgo extrac extractum; Character is: light brown extractum, and little smelly, be dissolved in alcohol, water insoluble.
The preparation of tincture: get above-mentioned Semen Ginkgo extrac extractum 100g, be dissolved in 600ml 95% alcoholic solution, again to wherein adding triethanolamine 50ml respectively, propylene glycol 200ml stirs, mend 95% alcoholic solution to capacity 1000ml, promptly get faint yellow Semen Ginkgo extrac tincture 1000ml, Semen Ginkgo extrac content is 10% (W/W).Be sub-packed in 50 tubules every 20ml.
Embodiment 4:
The ginkgo nut episperm is stripped down, dry, it is pulverized with pulverizer.Accurately take by weighing a certain amount of gingko episperm through pulverizing, adding solid-liquid ratio is 80% ether of 1: 6 (W/V), under 60 ℃ of bath temperatures, and stirring and leaching 2 times, each 4 hours extraction times.Lixiviate is used the nutsch filter sucking filtration after finishing, and collects filtrate.With rotary evaporation in vacuo instrument concentrated filtrate, condition is 55 ℃ of temperature, pressure 0.008-0.009MPa, concentrating under reduced pressure.In 60 ℃ of vacuum dryings, get Semen Ginkgo extrac extractum, character is: light brown extractum, little smelly, be dissolved in alcohol, water insoluble.
Get above-mentioned Semen Ginkgo extrac extractum 10g, prepare Semen Ginkgo extrac gel 1000g by embodiment 1 gel preparation technology, Semen Ginkgo extrac content is 1% (W/W).Be sub-packed in 50 tubules every 20g.
Embodiment 5:
With the Semen Ginkgo peeling, put into tissue mashing machine and pulverize.Accurately take by weighing a certain amount of Semen Ginkgo through pulverizing, adding solid-liquid ratio is 80% ethanol of 1: 10 (W/V), under 60 ℃ of bath temperatures, and stirring and leaching 2 times, each 4 hours extraction times.After lixiviate finished, centrifugal (5000 rev/mins, 15 minutes) got supernatant.With rotary evaporation in vacuo instrument concentrated supernatant, condition is 55 ℃ of temperature, pressure 0.008-0.009MPa, and concentrating under reduced pressure, and, get Semen Ginkgo extrac extractum in 60 ℃ of vacuum dryings, and character is: light brown extractum, and little smelly, be dissolved in alcohol, water insoluble.
Get above-mentioned Semen Ginkgo extrac extractum 200g, prepare Semen Ginkgo extrac tincture 1000ml by embodiment 3 tincture preparation technologies, Semen Ginkgo extrac content is 20% (W/W).Be sub-packed in 50 tubules every 20ml.
Embodiment 6:
With the Semen Ginkgo peeling, put into tissue mashing machine and pulverize.Accurately take by weighing a certain amount of Semen Ginkgo through pulverizing, adding solid-liquid ratio is the distilled water of 1: 10 (W/V), under 60 ℃ of bath temperatures, and stirring and leaching 2 times, each 4 hours extraction times.After lixiviate finished, centrifugal (5000 rev/mins, 15 minutes) got supernatant.Concentrated supernatant, and, get Semen Ginkgo extrac extractum in 60 ℃ of vacuum dryings, character is: light brown extractum, and little smelly, be dissolved in alcohol, water insoluble.
Get above-mentioned Semen Ginkgo extrac extractum 400g, prepare Semen Ginkgo extrac gel 1000g by embodiment 1 gel preparation technology, Semen Ginkgo extrac content is 40% (W/W).Be sub-packed in 50 tubules every 20g.
Embodiment 7:
With the Semen Ginkgo peeling, put into tissue mashing machine and pulverize.Accurately take by weighing a certain amount of Semen Ginkgo through pulverizing, adding solid-liquid ratio is 80% petroleum ether of 1: 10 (W/V), under 60 ℃ of bath temperatures, and stirring and leaching 2 times, each 4 hours extraction times.After lixiviate finished, centrifugal (5000 rev/mins, 15 minutes) got supernatant.With rotary evaporation in vacuo instrument concentrated supernatant, condition is 55 ℃ of temperature, pressure 0.008-0.009MPa, and concentrating under reduced pressure, and, get Semen Ginkgo extrac extractum in 60 ℃ of vacuum dryings, and character is: light brown extractum, and little smelly, be dissolved in alcohol, water insoluble.
Get above-mentioned Semen Ginkgo extrac extractum 1g, prepare Semen Ginkgo extrac ointment 1000g by embodiment 2 ointment preparation technologies, Semen Ginkgo extrac content is 0.1% (W/W).Be sub-packed in 50 tubules every 20g.
Embodiment 8:
Folium Ginkgo is shredded, put into pulverizer its pulverizing.Accurately take by weighing a certain amount of Folium Ginkgo through pulverizing, adding solid-liquid ratio is 80% ethanol of 1: 6 (W/V), under 60 ℃ of bath temperatures, and stirring and leaching 2 times, each 4 hours extraction times.After lixiviate finished, centrifugal (5000 rev/mins, 15 minutes) got supernatant.With rotary evaporation in vacuo instrument concentrated supernatant, condition is 55 ℃ of temperature, pressure 0.008-0.009MPa, and concentrating under reduced pressure, and, get Semen Ginkgo extrac extractum in 60 ℃ of vacuum dryings, and character is: light brown extractum, and little smelly, be dissolved in alcohol, water insoluble.
Get above-mentioned Semen Ginkgo extrac extractum 0.1g, prepare Semen Ginkgo extrac ointment 1000g by embodiment 2 ointment preparation technologies, Semen Ginkgo extrac content is 0.01% (W/W).Be sub-packed in 50 tubules every 20g.
Embodiment 9:
Folium Ginkgo is shredded, put into pulverizer its pulverizing.Accurately take by weighing a certain amount of Folium Ginkgo through pulverizing, adding solid-liquid ratio is the distilled water of 1: 6 (W/V), under 60 ℃ of bath temperatures, and stirring and leaching 2 times, each 4 hours extraction times.After lixiviate finished, centrifugal (5000 rev/mins, 15 minutes) got supernatant.Concentrated supernatant in 60 ℃ of vacuum dryings, gets Semen Ginkgo extrac extractum, and character is: light brown extractum, and little smelly, be dissolved in alcohol, water insoluble.
Get above-mentioned Semen Ginkgo extrac extractum 300g, prepare Semen Ginkgo extrac tincture 1000ml by embodiment 3 tincture preparation technologies, Semen Ginkgo extrac content is 30% (W/W).Be sub-packed in 50 tubules every 20ml.
Embodiment 10:
Folium Ginkgo is shredded, put into pulverizer its pulverizing.Accurately take by weighing a certain amount of Folium Ginkgo through pulverizing, adding solid-liquid ratio is the petroleum ether of 1: 6 (W/V), under 60 ℃ of bath temperatures, and stirring and leaching 2 times, each 4 hours extraction times.After lixiviate finished, centrifugal (5000 rev/mins, 15 minutes) got supernatant.With rotary evaporation in vacuo instrument concentrated supernatant, condition is 55 ℃ of temperature, pressure 0.008-0.009MPa, and concentrating under reduced pressure, and, get Semen Ginkgo extrac extractum in 60 ℃ of vacuum dryings, and character is: light brown extractum, and little smelly, be dissolved in alcohol, water insoluble.
Get above-mentioned Semen Ginkgo extrac extractum 20g, prepare Semen Ginkgo extrac gel 1000g by embodiment 1 gel preparation technology, Semen Ginkgo extrac content is 2% (W/W).Be sub-packed in 50 tubules every 20g.
In order to the Semen Ginkgo extrac external preparation that the top method is made, local irritation safety evaluatio experiment of being correlated with and clinic trial test.Be experimental data of the present invention below:
The local irritation experiment: get 8 of adult rabbit, male and female half and half, every animal sub-cage rearing was raised 3-4 days at laboratory condition earlier.Then rabbit spinal column both sides dorsal body setae is shaved off every lateral area 5 * 10cm with electric shaver-for women
2Whether scrutiny depilation district has redness and damage, if any abandoning it, can not test.Adopt the test method of multiple dosing, Semen Ginkgo extrac external preparation of the present invention is smeared in the district in depilation, every day 2 times, smears continuously 7 days.Whether last is smeared after 24 hours with warm water flush away smear, observes the local skin reaction after 1,24,48,72 hour, as erythema, edema, desquamation, incrustation etc., have petechia, skin peptide coarse or poor etc., record time of origin and regression time.Experimental result shows, is smearing Semen Ginkgo extrac external preparation of the present invention continuously after 7 days, and each rabbit skin does not all show tangible skin irritation and anaphylaxis.Show product safety of the present invention, have no adverse reaction.
Clinic trial test: on probation in order to the Semen Ginkgo extrac external preparation that the top method is made through the various skin patient, concrete case and see Table 1 course of treatment.All patients are coated with sufferer skin lesion place outward with the present invention, every day 2 times.The patient does not all use any other external preparation for skin medicine during treating.Criterion of therapeutical effect: cure: clinical skin lesion performance all disappears, and the pathogen microscopy is negative; Produce effects: the basic disappearance of clinical skin lesion performance, the pathogen microscopy is the weak positive; Effectively: clinical skin lesion performance part disappears, and the pathogen microscopy is the weak positive; Invalid: clinical skin lesion shows constant or increases the weight of, and the pathogen microscopy is positive.Cure rate=healing number/total case X100%; Effective percentage=(healing number+produce effects number+effective number)/total case X100%.The results are shown in Table 1.Clinic trial result shows that various skin patient uses Semen Ginkgo extrac external preparation of the present invention all effective, and effective percentage reaches 100%; Cure rate is all above 80%.All patients untoward reaction such as skin irritation, allergy all do not occur during using the present invention.Therefore the present invention is a kind of external preparation of ideal treatment various skin disease, and is evident in efficacy, safe and reliable.
Table 1 Semen Ginkgo extrac external preparation of the present invention is treated dermopathic clinical effectiveness
The present invention is compared with prior art: the present invention derives from natural precious medicinal plants Semen Ginkgo, from Folium Ginkgo, really, position such as episperm extracts and obtains Semen Ginkgo extrac, with the Semen Ginkgo extrac is that effective ingredient is made preparation for external application to skin, infectious, struvite and anaphylaxis dermatosis had significant therapeutical effect, and curative effect is better than glucocorticoid or antibiotic, the side effect due to no life-time service glucocorticoid, the antibiotic.Therefore Semen Ginkgo extrac external preparation of the present invention is safe in utilization, have no adverse reaction, and curative effect is outstanding aspect treatment various skin disease, has good potential applicability in clinical practice.
Claims (9)
1. Semen Ginkgo extrac is in the purposes of treatment in the dermatosis.
2. Semen Ginkgo extrac is preparing the purposes of preventing and treating in the dermopathic external preparation.
3. Semen Ginkgo extrac purposes as claimed in claim 2, described dermatosis are antibacterial, virus, fungus, parasite insect infection dermatoses; And struvite, allergy, anaphylaxis dermatosis.
4. Semen Ginkgo extrac purposes as claimed in claim 2, described dermatosis are various skin diseases such as impetigo, folliculitis, herpes, wart, tinea, eczema, urticaria, skin pruritus, dermatitis, acariasis, scabies, tinea unguium, clavus callus, psoriasis.
5. Semen Ginkgo extrac external preparation as claimed in claim 2 is the dermopathic medicine of the treatment that contains Semen Ginkgo extrac, cosmetics or disinfectant external preparation; And comprise Semen Ginkgo extrac and any combinations of substances is used for the treatment of dermopathic medicine, cosmetics or disinfectant external preparation; It is characterized in that described preparation is a said exterior-applied formulation on any pharmaceutics, can be liquid preparation, cream cream, gel, membrane, lotion, powder, aerosol spray, suppository, transdermal absorption formulation etc.
6. medicine as claimed in claim 5, cosmetics or disinfectant external preparation is characterized in that, contain Semen Ginkgo extrac 0.001-80%, by weight percentage.
7. medicine as claimed in claim 5, cosmetics or disinfectant external preparation is characterized in that, contain Semen Ginkgo extrac 0.001-30%, by weight percentage.
8. medicine as claimed in claim 5, cosmetics or disinfectant external preparation is characterized in that, contain Semen Ginkgo extrac 0.5-20%, by weight percentage.
9. described Semen Ginkgo extrac can be by the Chemical Decomposition method, from the leaf of Semen Ginkgo, really, obtain the extract at positions such as episperm, rhizome, extracts solvent and can be organic solvents such as ethanol, water, ether, petroleum ether; Or to Folium Ginkgo, really, episperm, rhizome extract elaboration products and reclaim again in the remaining waste material in extracting the course of processing.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751231A (en) * | 2013-09-11 | 2014-04-30 | 王青 | Application of gingko extract nanometer liposome in acne removing and dermatosis treatment |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284026A (en) * | 2007-04-12 | 2008-10-15 | 鲁南制药集团股份有限公司 | Chinese medicinal composition for treating skin hypersensitivity disease |
| CN101502537A (en) * | 2007-05-31 | 2009-08-12 | 北京凯瑞创新医药科技有限公司 | Application of ginkgo episperm dry distillation liquid in preparing medicament for treating or preventing fungal disease |
-
2011
- 2011-08-18 CN CN2011102367030A patent/CN102247411A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284026A (en) * | 2007-04-12 | 2008-10-15 | 鲁南制药集团股份有限公司 | Chinese medicinal composition for treating skin hypersensitivity disease |
| CN101502537A (en) * | 2007-05-31 | 2009-08-12 | 北京凯瑞创新医药科技有限公司 | Application of ginkgo episperm dry distillation liquid in preparing medicament for treating or preventing fungal disease |
Non-Patent Citations (2)
| Title |
|---|
| 余小妹等: "眼睑黄色瘤患者术后口服银杏叶片的临床观察", 《中国中医眼科杂志》 * |
| 富清等: "银杏制剂用于糖尿病合并皮肤病变疗效观察", 《中国冶金工业医学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751231A (en) * | 2013-09-11 | 2014-04-30 | 王青 | Application of gingko extract nanometer liposome in acne removing and dermatosis treatment |
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