CN113318046A - Composite plant anti-allergy agent, composite plant anti-allergy composition, preparation method and application thereof - Google Patents
Composite plant anti-allergy agent, composite plant anti-allergy composition, preparation method and application thereof Download PDFInfo
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- CN113318046A CN113318046A CN202110636874.6A CN202110636874A CN113318046A CN 113318046 A CN113318046 A CN 113318046A CN 202110636874 A CN202110636874 A CN 202110636874A CN 113318046 A CN113318046 A CN 113318046A
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- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 229940067463 momordica charantia fruit extract Drugs 0.000 description 1
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- 235000005152 nicotinamide Nutrition 0.000 description 1
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- 239000011607 retinol Substances 0.000 description 1
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- 238000010998 test method Methods 0.000 description 1
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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Abstract
The application relates to the technical field of anti-allergy, and particularly discloses a composite plant anti-allergy agent, a composite plant anti-allergy composition, a preparation method and application thereof. The compound plant anti-allergy agent is prepared from balsam pear extract, glycyrrhiza glabra root extract and corn silk extract, wherein the weight ratio of the balsam pear extract to the glycyrrhiza glabra root extract to the corn silk extract is (1-10): (1-5): (1-5). The composite plant anti-allergy composition is prepared from the following raw materials in parts by weight: 3-20 parts of composite plant anti-allergic agent, 0.05-0.2 part of betaine, 0.2-0.5 part of dipotassium glycyrrhizinate, 0.02-0.1 part of sodium hyaluronate and 0.1-0.5 part of carbomer; 0.02-0.1 part of preservative and 8-20 parts of humectant; the water is supplemented to 100 parts. The composite plant anti-allergy agent can be used for cosmetics, daily chemicals and anti-allergy products, and has the advantages of long-acting moisture retention, inflammation diminishing and anti-allergy.
Description
Technical Field
The application relates to the technical field of anti-allergy, in particular to a composite plant anti-allergy agent, a composite plant anti-allergy composition, a preparation method and application thereof.
Background
Common skin allergy is called hypersensitivity in medicine, and is also called allergy, which refers to abnormal specific immune response mainly caused by physiological dysfunction or tissue cell injury when the body is stimulated by certain antigens. This occurs depending on two factors: stimulation of antigens and reactivity of the body. Among them, the antigen inducing the allergic reaction is called allergen, and there are several hundreds of antigen substances inducing the allergic reaction, for example, several hundreds of pollen, dust, foreign proteins, chemical substances, ultraviolet rays, etc., which sensitize the body by inhalation, ingestion, injection, contact, etc. In the course of the allergic reaction, the allergic medium plays a direct role, the allergen is the external cause of the allergic disease, the body has low immunity, and the oxidative damage of a large number of free radicals to mast cells and basophils is the internal cause of the allergic disease.
Most of the common antigens causing skin allergy at present are simple chemical substances, and the skin of a contact person has allergic phenomena of redness, itching, red swelling, acne growing and the like. However, according to market research, most of the current cosmetics and daily chemical washing products have chemical substances which cause skin allergy, such as retinol, niacinamide, vitamin C, tartaric acid (AHA), turmeric, arbutin and other ingredients. How to reduce the skin allergic reaction of the chemical substances in the cosmetics on the basis of not reducing the concentration of the chemical substances is one of the industry problems which are urgently solved at present.
Disclosure of Invention
In order to improve the anti-inflammation and anti-allergy effects of the composite plant anti-allergy agent, the application provides the composite plant anti-allergy agent, the composite plant anti-allergy composition, and the preparation method and the application thereof.
In a first aspect, the application provides a composite plant anti-allergic agent, which adopts the following technical scheme:
a composite plant anti-allergy agent is prepared from a bitter gourd extract, a glycyrrhiza glabra root extract and a corn silk extract, wherein the weight ratio of the bitter gourd extract to the glycyrrhiza glabra root extract to the corn silk extract is (1-10): (1-5): (1-5).
By adopting the technical scheme, the compound plant anti-allergic agent is beneficial to better removing oxygen free radicals on the surface of skin or in skin cells after the glycyrrhiza glabra extract is added, the probability that histamine is released due to the rupture of cell membranes caused by the oxidation of mast cells and basophils in human bodies is reduced, and the anti-oxidation and anti-allergic effects of the compound plant anti-allergic agent on human body cells are improved. Meanwhile, the corn silk extract and the bitter gourd extract have a synergistic effect after being compounded, so that the anti-inflammation and anti-allergy effects of the composite plant anti-allergy agent can be effectively improved.
Preferably, the momordica charantia extract is selected from momordica charantia extract.
Preferably, the preparation method of the momordica charantia extract comprises the following operation steps:
(1) drying and crushing the momordica charantia, sieving the crushed momordica charantia with a 40-80-mesh sieve, adding ethanol, and controlling the weight ratio of the momordica charantia to the ethanol, namely: ethanol is 1: (10-20) mixing to obtain a mixed solution; leaching the obtained mixed solution at 20-30 deg.C for 1-2 hr, ultrasonic extracting for 0.5-3 hr, and filtering with 0.45 μm microporous membrane;
(2) and (2) carrying out vacuum rotary evaporation on the filtrate obtained after filtration in the step (1) under the condition of controlling the absolute vacuum degree to be 0.094-0.096MPa to obtain the extract of the momordica charantia.
By adopting the technical scheme, the MOMORDICA CHARANTIA EXTRACT (MOMORDICA CHARANTIA FRUIT EXTRACT) contains various nutritional ingredients such as protein, polysaccharide, flavonoid, triterpenes, saponins, steroids and alkaloids, and the like, and the current research shows that the various nutritional ingredients of the MOMORDICA CHARANTIA have good physiological effects of resisting oxidation, reducing fat, regulating immunity and the like. Then, an operator extracts the momordica charantia extract in an ultrasonic mode, so that the dissolving speed of active ingredients in the momordica charantia in ethanol can be improved, and micromolecular nutrient substances are left after nanofiltration, and the momordica charantia extract is easier to be absorbed by the skin of a human body in a transdermal mode.
In a second aspect, the present application provides a composite plant anti-allergy composition, which adopts the following technical scheme:
a composite plant anti-allergy composition is prepared from the following raw materials in parts by weight:
3-20 parts of a composite plant anti-allergic agent;
0.05-0.2 part of betaine;
0.2-0.5 part of dipotassium glycyrrhizinate;
0.02-0.1 part of sodium hyaluronate;
0.1-0.5 part of carbomer;
0.02-0.1 part of preservative;
8-20 parts of a humectant;
supplementing water to 100 parts;
the humectant is one or more of glycerol, butanediol and triethanolamine.
Preferably, the butanediol is 1, 3-butanediol.
By adopting the technical scheme, the balsam pear extract, the glycyrrhiza glabra root extract and the corn silk extract are used as main anti-allergy and anti-inflammation components, and the addition of the dipotassium glycyrrhizinate is helpful for improving the effects of anti-irritation, oil control, red swelling reduction, inflammation diminishing and healing of the composite plant anti-allergy composition. Then, a layer of protective film can be formed on the surface of the skin by adding the humectants such as glycerin, butanediol and the like, so that the loss of water, dipotassium glycyrrhizinate, bitter gourd extract and other active ingredients in the skin is effectively reduced, the long-acting water content of the skin is further improved, the amount of the active ingredients in cells is lower than that outside the cells, the transdermal absorption effect of the active ingredients such as glycyrrhiza glabra root extract, dipotassium glycyrrhizinate and bitter gourd extract is more favorably promoted, and meanwhile, free radicals and electrostatic particles on the surface of the skin can be effectively reduced. In addition, the added carbomer and the added betaine effectively improve the consistency and the dispersion performance of the composite plant anti-allergy composition, and the added sodium hyaluronate further improves the anti-wrinkle, moisturizing and thickening effects of the composite plant anti-allergy composition. Therefore, the synergistic effect among the components of the balsam pear extract, the dipotassium glycyrrhizinate, the butanediol and the like is recorded in experiments, so that the antibacterial, anti-inflammatory and anti-allergy effects of the composite plant anti-allergy composition on skin can be greatly improved.
Preferably, the composite plant anti-allergy composition is prepared from the following raw materials in parts by weight:
0.5-5 parts of bitter gourd extract;
0.1-0.15 part of betaine;
0.3-0.5 part of dipotassium glycyrrhizinate;
0.05-0.08 part of sodium hyaluronate;
0.2-0.4 part of carbomer;
0.02-0.05 part of preservative;
10-15 parts of a humectant;
the water is supplemented to 100 parts.
By adopting the technical scheme, the proportion and the dosage of the betaine, the dipotassium glycyrrhizinate, the sodium hyaluronate, the carbomer, the preservative, the composite plant anti-allergy agent and the humectant are optimally adjusted, so that the long-acting moisturizing, inflammation diminishing and anti-allergy effects of the composite plant anti-allergy composition on the skin can be further enhanced.
Preferably, the sodium hyaluronate is selected from small molecule sodium hyaluronate with molecular weight of 1-50 kDa.
Preferably, the sodium hyaluronate is selected from small molecule sodium hyaluronate with molecular weight of 1-3 kDa.
Preferably, the sodium hyaluronate is selected from the group consisting of small molecule sodium hyaluronate with a molecular weight of 1-3kDa and small molecule sodium hyaluronate with a molecular weight of 10-50kDa, and the weight ratio of the small molecule sodium hyaluronate with a molecular weight of 1-3kDa to the small molecule sodium hyaluronate with a molecular weight of 10-50kDa (1-300): (300: 1).
By adopting the technical scheme, the small-molecule sodium hyaluronate is added, so that the transdermal absorption rate of the skin to the composite plant anti-allergy composition is higher, and the water content of deep skin is supplemented. In addition, when two kinds of small molecule sodium hyaluronate with different molecular weights are adopted, the composite plant anti-allergy composition can supplement water content in skin cells at different depths (such as epidermis layer, stratum corneum layer, stratum granulosum layer, acanthosphere layer, stratum basale layer and dermis layer), and the long-acting water supplementing effect is better.
Preferably, the preservative is selected from one or more of benzyl alcohol, benzoic acid, salicylic acid, boric acid and sorbic acid.
By adopting the technical scheme, the benzyl alcohol, the benzoic acid, the salicylic acid, the boric acid and the sorbic acid are common preservatives for cosmetics, and the preservation time of the composite plant anti-allergy composition can be effectively prolonged.
Preferably, the preservative is selected from plant preservatives, and the plant preservatives are prepared from the following raw materials in parts by weight: 10-20 parts of medicinal sage, 10-20 parts of wormwood, 10-20 parts of usnea barbata, 5-10 parts of purple perilla and 5-10 parts of coptis chinensis; 1-3 parts of bamboo leaf extract and 3-5 parts of dandelion extract.
Preferably, the preparation method of the plant preservative comprises the following steps:
(1) weighing the raw materials according to the proportion, mixing, crushing and sieving by a 40-mesh sieve;
(2) mixing the mixture in the step (1) with 50-70% ethanol solution according to the weight ratio of 1:15-20, sealing and soaking for 3-5 hours;
(3) putting the raw material prepared in the step (2) into an ultrahigh pressure container, pressurizing at 200 and 400MPa, performing pressure-maintaining extraction for 5-10min, filtering the feed liquid to remove solid residues, performing extraction and reduced pressure concentration, and recovering ethanol until no alcohol smell exists;
(4) according to the weight ratio of 1: 2-1: 3, adding one or more of 1, 2-pentanediol, 1, 2-hexanediol and 1, 3-propanediol into the concentrated solution prepared in the step (3), carrying out suction filtration, centrifuging and taking supernate to obtain the plant preservative.
By adopting the technical scheme, the plant preservative is used as the preservative of the composite plant anti-allergy composition, and has the effects of being natural, free of stimulation and good in preservative property; uses safe and harmless natural plants as raw materials to replace chemical preservatives synthesized in chemical industry, minimizes the damage to skin cells of human bodies, and has no stimulation or anaphylactic reaction. Secondly, the composite plant anti-allergy composition added with the plant preservative has better inhibiting effect on various harmful bacteria species including gram-negative bacteria such as escherichia coli and the like, and various gram-positive bacteria and fungi such as bacillus subtilis, streptococcus and the like.
In a third aspect, the application provides a preparation method of a composite plant anti-allergy composition, which adopts the following technical scheme:
a preparation method of a composite plant anti-allergy composition comprises the following operations: the compound plant anti-allergy composition can be prepared by uniformly mixing the momordica charantia extract, the betaine, the dipotassium glycyrrhizinate, the sodium hyaluronate, the carbomer, the preservative, the humectant and the water according to the proportion.
By adopting the technical scheme, the operation mode is simple and convenient, and the prepared composite plant anti-allergy composition has stable long-acting moisturizing, anti-inflammation and anti-allergy effects.
In a fourth aspect, the application provides an application of a composite plant anti-allergy agent in preparation of cosmetics, daily chemicals and anti-allergy products, wherein the addition amount of the composite plant anti-allergy agent is 1-10% by weight.
In summary, the present application has the following beneficial effects:
1. the anti-inflammation and anti-allergy effects of the composite plant anti-allergy agent can be effectively improved by the synergistic effect of the corn silk extract and the bitter gourd extract after compounding. The addition of the glycyrrhiza glabra extract is helpful for the composite plant anti-allergic agent to better remove oxygen free radicals on the surface of the skin or in skin cells, and further enhances the anti-oxidation and anti-allergic effects of the composite plant anti-allergic agent on human body cells.
2. Because the compound plant anti-allergic agent, the dipotassium glycyrrhizinate, the glycerol, the butanediol, the carbomer, the betaine and the sodium hyaluronate are compounded, redundant free radicals on the surface of the skin or in skin cells can be effectively removed, the probability that the cell membrane is broken to release histamine due to the fact that mast cells and basophils in a human body are oxidized is reduced, and the effects of resisting oxidation and allergy of the human body cells are improved. And the composite plant anti-allergy composition can form a layer of protective film on the surface of skin, effectively reduces the loss of active ingredients such as moisture, dipotassium glycyrrhizinate and bitter gourd extract in the skin, improves the long-acting water content of the skin, enables the content of the active ingredients in cells to be lower than that outside the cells, and is more favorable for promoting the transdermal absorption efficiency of the active ingredients.
3. The plant preservative is preferably adopted in the application, and as all components of the plant preservative are natural components and other allergens are not introduced, the preservation time of the compound plant anti-allergy composition can be prolonged; but also can be compounded with betaine, dipotassium glycyrrhizinate, Momordica charantia extract and 1, 3-butanediol in the compound plant anti-allergy composition, thereby greatly enhancing the anti-inflammatory and anti-allergy effects.
4. The method has simple and convenient operation mode, and the prepared composite plant anti-allergy composition has stable long-acting moisturizing, anti-inflammation and anti-allergy effects.
Detailed Description
The present application will be described in further detail with reference to examples.
The raw materials used in the examples of the present application are all commercially available products, except for the following specific descriptions.
The Glycyrrhiza glabra extract is selected from Glycyrrhiza glabra extract (fine powder, specification 10:1) produced by Shaanxi Sinot biotechnology limited.
The stigma Maydis extract is selected from stigma Maydis extract (brown powder, specification 10:1) of Sierra Tetraphyllum Biotech limited.
The betaine is selected from anhydrous betaine (CAS number: 107-43-7, density: 1.00g/ml 20 deg.C, white powder) produced by Xianweizhen biotechnology limited in Shanxi province.
The carbomer is selected from carbomer 940 available from Shanghai Yuan leaf Biotech, Inc. under the product number S31102-250 g.
The dipotassium glycyrrhizinate is selected from dipotassium glycyrrhizinate with the product number of B20421-20mg from Shanghai-sourced leaf Biotechnology Co.
The triethanolamine was selected from triethanolamine (purity: 97%, CAS number: 102-71-6) manufactured by Changzhou Huanyuan chemical Co., Ltd.
Preparation examples 1 to 4
Preparation example 1: a fructus Momordicae Charantiae extract is prepared by the following steps:
(1) drying and crushing the momordica charantia, sieving the crushed momordica charantia with a 50-mesh sieve, adding ethanol, and controlling the weight ratio of the momordica charantia to the ethanol, namely: ethanol is 1:15 mixing to obtain a mixed solution; leaching the obtained mixed solution at 25 deg.C for 1.5h, then extracting with ultrasonic wave for 2h, and filtering with 0.45 μm microporous membrane;
(2) and (2) carrying out vacuum rotary evaporation on the filtrate obtained after filtration in the step (1) under the condition that the absolute vacuum degree is controlled to be 0.095MPa, so as to obtain the extract of the momordica charantia.
Preparation example 2: a fructus Momordicae Charantiae extract is prepared by the following steps:
(1) drying and crushing the momordica charantia, sieving the crushed momordica charantia with a 40-mesh sieve, adding ethanol, and controlling the weight ratio of the momordica charantia to the ethanol, namely: ethanol is 1: 10 mixing to obtain a mixed solution; leaching the obtained mixed solution at 20 deg.C for 1 hr, performing ultrasonic extraction for 0.5 hr, and filtering with 0.45 μm microporous membrane;
(2) and (2) carrying out vacuum rotary evaporation on the filtrate obtained after filtration in the step (1) under the condition that the absolute vacuum degree is controlled to be 0.094MPa, so as to obtain the extract of the momordica charantia.
Preparation example 3: a fructus Momordicae Charantiae extract is prepared by the following steps:
(1) drying and crushing the momordica charantia, sieving the crushed momordica charantia with a 80-mesh sieve, adding ethanol, and controlling the weight ratio of the momordica charantia to the ethanol, namely: ethanol is 1:20 mixing to obtain a mixed solution; leaching the obtained mixed solution at 30 ℃ for 2h, then performing ultrasonic extraction for 3h, and filtering by using a 0.45-micron microporous filter membrane;
(2) and (2) carrying out vacuum rotary evaporation on the filtrate obtained after filtration in the step (1) under the condition that the absolute vacuum degree is controlled to be 0.096MPa, so as to obtain the extract of the momordica charantia.
Preparation example 4: a Momordica charantia extract is different from that in preparation example 1 in that the Momordica charantia extract is obtained from Momordica charantia (purity 30%, specification 10:1, light yellow to brown yellow powder) produced by Shaanxi Sinoensis biotechnology limited.
Preparation examples A to C
Preparation example a: a plant preservative is prepared from the following raw materials in parts by weight: 15 g of salvia miltiorrhiza, 15 g of wormwood, 15 g of usnea barbata, 8 g of purple perilla and 8 g of coptis chinensis; 2 g of bamboo leaf extract and 4 g of dandelion extract.
The preparation method comprises the following steps:
(1) weighing the raw materials according to the proportion, mixing, crushing and sieving by a 40-mesh sieve;
(2) mixing the mixture in the step (1) with 60% ethanol solution according to the weight ratio of 1:17, and sealing and soaking for 4 hours;
(3) putting the raw material prepared in the step (2) into an ultrahigh pressure container, pressurizing to 300MPa, performing pressure maintaining extraction for 8min, filtering the feed liquid to remove solid residues, performing reduced pressure concentration on the extraction, and recovering ethanol until no alcohol smell exists;
(4) according to the weight ratio of 1:2, adding 1, 2-hexanediol into the concentrated solution prepared in the step (3), performing suction filtration, and centrifuging to obtain a supernatant, thereby obtaining the plant preservative.
Preparation example B: a plant preservative is prepared from the following raw materials in parts by weight: 10 g of salvia miltiorrhiza, 10 g of wormwood, 10 g of usnea barbata, 5 g of perilla and 5 g of coptis chinensis; 1 g of bamboo leaf extract and 3 g of dandelion extract.
The preparation method comprises the following steps:
(1) weighing the raw materials according to the proportion, mixing, crushing and sieving by a 40-mesh sieve;
(2) mixing the mixture in the step (1) with 50% ethanol solution according to the weight ratio of 1:15, and sealing and soaking for 3 hours;
(3) putting the raw material prepared in the step (2) into an ultrahigh pressure container, pressurizing to 200MPa, performing pressure-maintaining extraction for 5-10min, filtering the feed liquid to remove solid residues, performing reduced pressure concentration on the extraction, and recovering ethanol until no alcohol smell exists;
(4) according to the weight ratio of 1:2, adding 1, 2-pentanediol into the concentrated solution prepared in the step (3), carrying out suction filtration, centrifuging and taking supernate to obtain the plant preservative.
Preparation example C: a plant preservative is prepared from the following raw materials in parts by weight: 20 g of salvia miltiorrhiza, 20 g of wormwood, 20 g of usnea barbata, 10 g of perilla and 10 g of coptis chinensis; 3 g of bamboo leaf extract and 5 g of dandelion extract.
The preparation method comprises the following steps:
(1) weighing the raw materials according to the proportion, mixing, crushing and sieving by a 40-mesh sieve;
(2) mixing the mixture in the step (1) with 70% ethanol solution according to the weight ratio of 1:20, sealing and soaking for 5 hours;
(3) putting the raw material prepared in the step (2) into an ultrahigh pressure container, pressurizing to 400MPa, performing pressure maintaining extraction for 10min, filtering the feed liquid to remove solid residues, performing reduced pressure concentration on the extraction, and recovering ethanol until no alcohol smell exists;
(4) according to the weight ratio of 1: 3, adding a mixture of 1, 2-pentanediol, 1, 2-hexanediol and 1, 3-propanediol into the concentrated solution prepared in the step (3), wherein the weight ratio of the 1, 2-pentanediol, the 1, 2-hexanediol and the 1, 3-propanediol is 1:1:0.5, carrying out suction filtration, centrifuging and taking supernatant fluid to obtain the plant preservative.
Examples
The first embodiment is as follows: a composite plant anti-allergy agent is prepared from the following raw materials in parts by weight: 8 g of balsam pear extract; 5 g of glycyrrhiza glabra root extract; 3 g of corn silk extract. Wherein the weight ratio of the balsam pear extract to the glycyrrhiza glabra root extract to the corn silk extract is 8:5: 3.
The preparation method of the composite plant anti-allergic agent comprises the following steps: 8 g of balsam pear extract is added under normal temperature and pressure; 5 g of glycyrrhiza glabra root extract; 3 g of the corn silk extract is put into a B10-1 egg beater (power is 0.45kw, manufacturer is Zhuhai Jia Baode science and technology Co., Ltd.) with the capacity of 10L, and the mixture is uniformly mixed according to the rotating speed of 300 r/min to prepare the composite plant anti-allergy agent.
Example two: a composite plant anti-allergic agent is different from the first embodiment in that: the composite plant anti-allergic agent is prepared from the following raw materials in parts by weight: 1 g of balsam pear extract; 1 g of glycyrrhiza glabra root extract; 1 g of corn silk extract. Wherein the weight ratio of the balsam pear extract to the glycyrrhiza glabra root extract to the corn silk extract is 1:1: 1.
Example three: a composite plant anti-allergic agent is different from the first embodiment in that: the composite plant anti-allergic agent is prepared from the following raw materials in parts by weight: 10 g of balsam pear extract; 5 g of glycyrrhiza glabra root extract; 5 g of corn silk extract. Wherein the weight ratio of the balsam pear extract to the glycyrrhiza glabra root extract to the corn silk extract is 2:1: 1.
Example 1: a composite plant anti-allergy composition comprises the components and the dosage of each raw material in the composite plant anti-allergy composition, which are shown in the table 1. The method comprises the following operation steps: the momordica charantia extract, the betaine, the dipotassium glycyrrhizinate, the sodium hyaluronate, the carbomer, the preservative, the humectant and the deionized water are put into a type B10-1 egg beater (the power is 0.45kw, and the manufacturer is Zhuhai Jia Baodede technology Co., Ltd.) with the capacity of 10L and are uniformly mixed at normal temperature and normal pressure according to the rotating speed of 500 revolutions per minute to prepare the composite plant anti-allergy composition.
Examples 2 to 16: a composite plant anti-allergy composition, which is different from that of example 1 in that: the ingredients and the dosage of each raw material in the composite plant anti-allergy composition are shown in table 1.
TABLE 1 composite plant anti-allergy composition the ingredients and amounts (grams) of the raw materials of examples 1-7
TABLE 2 composite plant anti-allergy composition the ingredients and amounts (g) of the raw materials of examples 8-16
Example 17: a composite plant anti-allergy composition, which differs from example 16 in that: the preservative was sorbic acid and the plant preservative of preparation 1, wherein sorbic acid was 0.02 g and the plant preservative of preparation 1 was 0.03 g.
Example 18: a composite plant anti-allergy composition, which differs from example 16 in that: the preservative was sorbic acid and the plant preservative of preparation 1, wherein sorbic acid was 0.05 g and the plant preservative of preparation 1 was 0.05 g.
Example 19: a composite plant anti-allergy composition, which differs from example 17 in that: the sorbic acid is replaced by salicylic acid.
Example 20: a composite plant anti-allergy composition, which differs from example 17 in that: benzyl alcohol and sorbic acid were substituted for salicylic acid and the plant preservative of preparation 1. With benzyl alcohol 0.02 g and sorbic acid 0.03 g.
Example 21: a composite plant anti-allergy composition, which differs from example 17 in that: the compound botanical anti-sensitization agent of example two was used in place of 0.75 grams of the extract of momordica charantia of preparative example 1 and 0.25 grams of the extract of momordica charantia of preparative example 4, with the balance of deionized water to 100 grams (i.e., deionized water reduced to 86.12 grams).
Example 22: a composite plant anti-allergy composition, which differs from example 21 in that: 16 g of the composite plant anti-allergy agent of the first embodiment is adopted to replace 3 g of the composite plant anti-allergy agent of the second embodiment, and deionized water is added to make up to 100 g.
Example 23: a composite plant anti-allergy composition, which is different from that of example 22 in that: 20 g of the composite plant anti-allergic agent of the third embodiment is adopted to replace 3 g of the composite plant anti-allergic agent of the second embodiment, and deionized water is added to make up to 100 g.
Example 24: a composite plant anti-allergy composition, which is different from that of example 22 in that: 1 g of the composite plant anti-allergic agent of the second embodiment is adopted to replace 3 g of the composite plant anti-allergic agent of the second embodiment, and deionized water is added to make up to 100 g.
Example 25: a composite plant anti-allergy composition, which is different from that of example 22 in that: 20 g of the composite plant anti-allergic agent of the second embodiment is adopted to replace 3 g of the composite plant anti-allergic agent of the second embodiment, and deionized water is added to make up to 100 g.
Comparative example
Comparative example 1: an anti-allergy composition, which differs from example 17 in that: no preservative was included and the balance was made up to 100 grams with deionized water.
Comparative example 2: an anti-allergy composition, which differs from example 17 in that: the preservative was 0.025 grams of the plant preservative of preparation 1.
Comparative example 3: an anti-allergy composition, which differs from example 17 in that: does not contain the extract of the momordica charantia and is made up to 100 g by deionized water.
Comparative example 4: an anti-allergy composition, which differs from example 17 in that: extract of Momordica charantia was prepared using 0.2 g of preparation example 1.
Comparative example 5: an anti-allergy composition, which differs from example 17 in that: it does not contain dipotassium glycyrrhizinate.
Comparative example 6: an anti-sensitivity agent which differs from example 17 in that: 1, 3-butanediol is not contained.
Performance test
Test a test subject: examples 1 to 25 composite plant anti-allergy compositions prepared in examples 1 to 25 were used as test samples 1 to 25; comparative examples 1 to 6 the anti-sensitivity agents prepared were used as control samples 1 to 6.
Positive control: B. the C group is triamcinolone acetonide ointment, the E group is rutin, and the F group is ethylhexylglycerin.
Sample method:
A. irritation: according to technical Specification for safety of cosmetics 2015, repeated irritation experiments are carried out on guinea pig skin, and the irritation intensity is counted.
B. Anti-allergic itching-relieving: histamine tolerance test
Grouping guinea pigs: test sample 1-25, control sample 1-6, triamcinolone acetonide acetate urea soft plaster group and distilled water negative control group, after depilation, each group is respectively smeared with the tested medicine 4 times, 2 times a day, 0.025mL each time, and the area is about 1.1cm2Wrapping with gauze after natural film formation, fixing with adhesive tape, and topically applying the extract to the administration group at 1.2cm2Then bandaged and fixed. On the 3 rd day, the skin of the depilated area of the back of the right foot is gently rubbed with fine sand paper to make the depilated area red but not bleed, then 0.2mL of the tested drug is applied to the wound surface, the tested drug is gently removed after 40min, 0.03mL of histamine is applied to the back of the foot of each guinea pig from low concentration to high concentration in sequence every 3min, and when the guinea pig has an itching reaction, the amount of histamine given to each guinea pig is accumulated, namely the histamine tolerance amount of the guinea pig.
C. Anti-inflammatory: experiment for mouse auricle swelling caused by xylene
The right ear of the mouse is coated with each group of corresponding medicines, 0.2ml of each group of medicines is coated once a day for 3 days continuously, 30min after the last administration, 100% dimethylbenzene inflammation-causing liquid is coated on the front and back surfaces of the right ear of the mouse, the left ear is not treated, the animal is killed after 4 hours, two ears are cut off immediately, the ear at the same part is taken by an 8mm puncher, the ear is weighed on an analytical balance, the swelling degree is determined by subtracting the weight of the left ear from the weight of the right ear, and the swelling rate is determined by (the weight of the right ear-the weight of the left ear)/the weight of the left ear multiplied by 100%.
D. Skin barrier function test
66 healthy dry skin volunteers, Corneometer (CK) as the test instrument, measured the TEWL value (transdermal water loss) at the time point designated A before use of the sample04w after the use of the sample is denoted as A1The 4-week TEWL reduction rate (A)1-A0)÷A0*100％。
E. DPPH free radical scavenging test
Pipette 90. mu.l of 2X 10-4Adding mol/L DPPH into a 96-well plate, and respectively adding 10 mu L of rutin standard substances or drugs to be detected with different concentrations, wherein three concentrations are arranged in parallel; a control group containing 90. mu.l of DPPH solution and 10. mu.l of ethanol solution and a blank group containing anhydrous ethanol were set. Reacting at room temperature for 30min, and rapidly measuring absorbance at 517nm with MD microplate reader.
DPPH radical scavenging Rate/% - [1-A ]i/Ao]×100％；
Wherein A is0- (blank control withholding control group absorbance); a. thei- (medicine combination buckle)Remove control group absorbance).
At least the DPPH radical scavenging ability at 3 concentrations was measured, and IC was calculated50I.e. the concentration of the sample solution at which the inhibition of DPPH is 50%, IC50The smaller the oxidation resistance, the stronger the oxidation resistance.
F. Bacteriostatic test-determination of minimum inhibitory concentration (MIC value)
The test strain is Staphylococcus aureus (ATCC 6538), and a microplate method is adopted. Adding 100 μ L of Staphylococcus aureus and 100 μ L of medicinal liquid into the micropores, simultaneously setting negative control without adding bacteria and normal growth control without adding medicinal liquid, making 3 parallels for each medicine, and taking average value. And incubating the staphylococcus aureus-containing sample in an incubator at 35 ℃, and observing the result after 24 hours. The data were read directly by visual observation. The premise of result judgment is that the growth contrast is good, the blank contrast aseptically grows clearly, and the growth of bacteria in other holes is inhibited along with the increase of the drug concentration gradient.
TABLE 3
As can be seen by combining examples 1-20 and comparative examples 1-6, blank group and positive control group, and by combining Table 3, examples 1-20 are superior to comparative examples 1-6 in irritation, anti-allergic, antipruritic, anti-inflammatory, detumescence, barrier strengthening, radical scavenging and bacteriostatic effects. According to analysis, the indexes of example 17 are best.
It can be seen from the combination of examples 7 to 9 and table 3 that when sodium hyaluronate (10-50kDa) and sodium hyaluronate (1-3kDa) are combined, the indexes of sodium hyaluronate are optimized to a smaller extent than those of sodium hyaluronate alone, so that when sodium hyaluronate with two or more molecular weights is selected, the skin can absorb effective components in the composite plant anti-allergy composition better, and the anti-inflammatory, antibacterial and barrier effects of skin are enhanced.
It can be seen from the combination of examples 9-12, comparative examples 1-2 and table 3 that the plant preservatives selected in preparation example a have anti-irritant effects on the skin, the non-plant preservatives have certain irritant properties (weak irritant effects) on the skin, and the anti-allergic effects can be effectively reduced by using the plant preservatives, and from examples 15-20, it can be seen that the irritation effects brought by the compounds of preparation example 1 are neutralized when 0.02 g of sorbic acid is added and 0.03 g of the plant preservatives is added in example 17, and the anti-allergic, antipruritic, anti-inflammatory, detumescence, barrier strengthening, radical scavenging and bacteriostatic effects reach a high level. Therefore, the addition of the plant preservative not only can reduce the addition of the anti-allergen on the root, but also can achieve the stimulation effect brought by neutralizing other preservatives added.
Combining example 17, comparative examples 1-6 and table 3, it can be seen that comparative examples 1-6 reduce or reduce the components of the momordica charantia extract, dipotassium glycyrrhizinate, 1, 3-butanediol and preservatives, so that the effects of irritation, anti-allergic itching relieving, anti-inflammatory swelling diminishing, barrier strengthening, radical scavenging and bacteriostasis are far inferior to those of example 17, and thus it is known that the momordica charantia extract, dipotassium glycyrrhizinate, 1, 3-butanediol and preservatives have synergistic effect, and the effect of the composite plant anti-allergic composition can be affected by the single absence of any one component.
Combining examples 17, 21-25 and comparative examples 1-6, and combining table 3, it can be seen that the irritation, anti-allergic itching, anti-inflammatory swelling, barrier enhancement, radical scavenging and bacteriostatic efficacy of the composite plant anti-allergic composition obtained by using the composite plant anti-allergic agent of examples one to three instead of the extract of momordica charantia are better than those of comparative examples 1-6, and the irritation, anti-allergic itching, anti-inflammatory swelling, barrier enhancement, radical scavenging and bacteriostatic efficacy of the plant anti-allergic composition of examples 21-23 are similar to those of the plant anti-allergic composition of example 17, wherein the irritation, anti-allergic itching, anti-inflammatory swelling, barrier enhancement, radical scavenging and bacteriostatic efficacy of example 22 are further better than those of example 17, and thus it can be seen that the extract of momordica charantia used in the present application has a synergistic effect after being compounded with the extract of glycyrrhiza glabra root and the extract of corn silk, compared with the single momordica charantia extract, the momordica charantia extract has better irritation, anti-allergy, itching relieving, anti-inflammation, detumescence, barrier strengthening, free radical purification and bacteriostasis effects.
Test two test subjects: the composite plant anti-allergy composition prepared in example 17 was used as a test sample 17, the composite plant anti-allergy composition prepared in example 22 was used as a test sample 22, and the anti-allergy agents prepared in comparative examples 1 to 6 were used as control samples 1 to 6; 2, 4-dinitrochlorobenzene was used as a positive control, compound dexamethasone acetate ointment (30g:22.5mg) was used as a sample control, and a blank control group.
The test method comprises the following steps:
2, 4-dinitrochlorobenzene as positive control: 2, 4-dinitrochlorobenzene (CNCB) is prepared into 1 percent of CNCB petroleum jelly for induction contact by medical vaseline, and is prepared into 0.5 percent of CNCB petroleum jelly for excitation contact.
Compound dexamethasone acetate ointment (30g:22.5 mg): huarun Sanjiu medicine.
Under the conditions of temperature of 20 +/-2 ℃ and relative humidity of 60-70%, 40 healthy white guinea pigs are selected, half male and female, the weight of 250-. Guinea pigs were divided equally into groups of 10 animals each, see table 4 for details.
1) And (3) induction contact: 0.2 g of 1% CNCB vaseline oil cream was applied to the left side of the guinea pigs in the test sample group, the positive control group and the sample control group, and the application was repeated once again in the same manner as described above on day 7 and day 14, respectively.
2) Smearing the test sample: test sample 17 was applied to the right side of the guinea pigs in the sample group in the same manner while contact application was induced, once a day for 28 consecutive days. Control samples 1-6 and sample control groups of guinea pigs were treated in the same manner as described above.
3) And (3) exciting contact: 0.2 g of 0.5% CNCB petrolatum was applied to the right test area of each group of guinea pigs 14 days after the last induction and the skin response in the test area was observed after 24 hours of contact.
4) And (4) judging the standard: when the reaction value of the test guinea pig with erythema is more than or equal to 1, the guinea pig is judged to have skin allergy positive reaction.
TABLE 4
Combining example 17, comparative examples 1-6, and table 4, it can be seen that the sensitization rate of example 17 is significantly lower than that of comparative examples 1-6, and the sensitization rate of example 17 is close to that of the sample control group. Therefore, the compound plant anti-allergy agent has a good effect of relieving allergy and can play a certain anti-allergy effect. And in combination with the comparative examples 1-6, the lack of any one of the extract of the momordica charantia, the dipotassium glycyrrhizinate and the 1, 3-butanediol alone can affect the anti-allergy effect of the product, so the compound of the extract of the momordica charantia, the dipotassium glycyrrhizinate and the 1, 3-butanediol has synergistic effect.
As can be seen by combining example 17 and example 22, and table 4, the sensitization rate in example 22 is further lower than that in example 17, and it is found that the combination effect of the momordica charantia extract, the glycyrrhiza glabra extract, and the stigma Maydis extract is better than the combination effect of the momordica charantia extract, dipotassium glycyrrhizinate, and 1, 3-butanediol.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (10)
1. The compound plant anti-allergy agent is characterized by being prepared from a bitter gourd extract, a glycyrrhiza glabra root extract and a corn silk extract, wherein the weight ratio of the bitter gourd extract to the glycyrrhiza glabra root extract to the corn silk extract is (1-10): (1-5): (1-5).
2. The compound plant antiallergic agent as claimed in claim 1, wherein the Momordica charantia extract is selected from an extract of Momordica charantia.
3. The compound plant antiallergic agent of claim 2, wherein the preparation method of the extract of Momordica charantia comprises the following steps:
(1) drying and crushing the momordica charantia, sieving the crushed momordica charantia with a 40-80-mesh sieve, adding ethanol, and controlling the weight ratio of the momordica charantia to the ethanol, namely: ethanol is 1: (10-20) mixing to obtain a mixed solution; leaching the obtained mixed solution at 20-30 deg.C for 1-2 hr, ultrasonic extracting for 0.5-3 hr, and filtering with 0.45 μm microporous membrane;
(2) and (2) carrying out vacuum rotary evaporation on the filtrate obtained after filtration in the step (1) under the condition of controlling the absolute vacuum degree to be 0.094-0.096MPa to obtain the extract of the momordica charantia.
4. The composite plant anti-allergy composition is characterized by being prepared from the following raw materials in parts by weight:
3-20 parts of the composite plant antiallergic agent described in any one of claims 1 to 3;
0.05-0.2 part of betaine;
0.2-0.5 part of dipotassium glycyrrhizinate;
0.02-0.1 part of sodium hyaluronate;
0.1-0.5 part of carbomer;
0.02-0.1 part of preservative;
8-20 parts of a humectant;
supplementing water to 100 parts;
the humectant is one or more of glycerol, butanediol and triethanolamine.
5. The composite plant anti-allergy composition is characterized by being prepared from the following raw materials in parts by weight:
0.5 to 5 parts of an extract of momordica charantia according to any one of claims 1 to 3;
0.1-0.15 part of betaine;
0.3-0.5 part of dipotassium glycyrrhizinate;
0.05-0.08 part of sodium hyaluronate;
0.2-0.4 part of carbomer;
0.02-0.05 part of preservative;
10-15 parts of a humectant;
the water is supplemented to 100 parts.
6. The composite plant anti-allergy composition according to claim 4, wherein the sodium hyaluronate is selected from the group consisting of small molecule sodium hyaluronate with a molecular weight of 1-50 kDa.
7. The composite plant anti-allergy composition according to claim 4, wherein the preservative is selected from one or more of benzyl alcohol, benzoic acid, salicylic acid, boric acid and sorbic acid.
8. The composite plant anti-allergy composition according to claim 4, wherein the preservative is selected from plant preservatives, and the plant preservatives are prepared from the following raw materials in parts by weight: 10-20 parts of medicinal sage, 10-20 parts of wormwood, 10-20 parts of usnea barbata, 5-10 parts of purple perilla and 5-10 parts of coptis chinensis; 1-3 parts of bamboo leaf extract and 3-5 parts of dandelion extract.
9. The method for preparing a composite plant anti-allergy composition according to claim 4, comprising the following operations: the compound plant anti-allergy composition can be prepared by uniformly mixing the momordica charantia extract, the betaine, the dipotassium glycyrrhizinate, the sodium hyaluronate, the carbomer, the preservative, the humectant and the water according to the proportion.
10. Use of the composite plant anti-allergy agent according to any one of claims 1 to 3 in the preparation of cosmetics, household chemicals and anti-allergy products, wherein the composite plant anti-allergy agent is added in an amount of 1 to 10% by weight.
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| CN107137293A (en) * | 2017-06-29 | 2017-09-08 | 芜湖凌梦电子商务有限公司 | A kind of oil-control biological cleanser and preparation method thereof |
| CN110200875A (en) * | 2019-07-09 | 2019-09-06 | 中山卡丝生物科技有限公司 | A kind of antiallergic whitening mask and preparation method thereof |
| CN110522658A (en) * | 2019-09-23 | 2019-12-03 | 周璇 | A kind of antiallergic remediation composition and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107137293A (en) * | 2017-06-29 | 2017-09-08 | 芜湖凌梦电子商务有限公司 | A kind of oil-control biological cleanser and preparation method thereof |
| CN110200875A (en) * | 2019-07-09 | 2019-09-06 | 中山卡丝生物科技有限公司 | A kind of antiallergic whitening mask and preparation method thereof |
| CN110522658A (en) * | 2019-09-23 | 2019-12-03 | 周璇 | A kind of antiallergic remediation composition and preparation method thereof |
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Application publication date: 20210831 |