CN113520948A - Balanced grease composition for inhibiting activity of 5 alpha-reductase and oil control gel thereof - Google Patents
Balanced grease composition for inhibiting activity of 5 alpha-reductase and oil control gel thereof Download PDFInfo
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- CN113520948A CN113520948A CN202110915319.7A CN202110915319A CN113520948A CN 113520948 A CN113520948 A CN 113520948A CN 202110915319 A CN202110915319 A CN 202110915319A CN 113520948 A CN113520948 A CN 113520948A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention belongs to the technical field of cosmetics, and discloses a balanced grease composition for inhibiting 5 alpha-reductase activity and an oil-controlling gel thereof, wherein the balanced grease composition comprises a solvent, a thickener, a humectant, a preservative, a corrosion agent, a pH regulator and the balanced grease composition, and the preparation method of the preparation comprises the following steps: s1, accurately weighing each component material in the formula components, and cleaning production equipment; s2, adding the solvent, the humectant and the thickener into an emulsifying pot, stirring and heating to 85-90 ℃, starting a homogenizer for homogenizing for 3-5 minutes, completely dissolving, and sterilizing at constant temperature for 10 min; s3, stirring and cooling to 70-75 ℃, adding the preservative, stirring for 3 minutes, vacuumizing, keeping the temperature and defoaming completely; and S4, cooling to 40-45 ℃ by stirring, sequentially adding a pH regulator, an ester-forming agent and a acne muscle conditioning composition, and uniformly stirring to complete the preparation.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a balanced grease composition for inhibiting 5 alpha-reductase activity and an oil control gel thereof.
Background
The sebaceous gland is an important gland attached to the skin and is an important part for producing sebum, and the anatomy and the tissue structure of the human skin indicate that: the sebaceous gland is a vesicular gland which opens more into the upper part of the hair follicle and whose secretion is also increased after the development of the second characteristic, and is significantly affected by androgens. Sebaceous glands can secrete sebum, enter the skin sac through the catheter and then are discharged to the surface of the skin through pores.
Sebum is an oily semi-fluid mixture containing various lipids, mainly comprising triglyceride, fatty acid, phospholipid, cholesterol, etc. Normally excreted sebum has 3 effects: 1) moistening skin and hair; 2) sebum can form a lipid membrane together with sweat to protect the skin and prevent the evaporation of skin moisture; 3) sebum exhibits weak acidity and can inhibit and kill bacteria on the skin surface. In addition, sebaceous glands are also important as an epidermal appendage for the maintenance of a stable state of skin balance.
Many factors affect sebaceous gland secretion, mainly relating to endocrine quantity, skin moisture, age and sex, and dietary nutrition.
Age and sex 1
Sebaceous gland secretion functions are relatively strong at birth, and decrease to a very low level after 6 months, and remain low during childhood. At the beginning of puberty, sebaceous gland secretion increases gradually in both males and females, reaching a peak at age 16-20 and remaining at this level later, with females at age 40 and males after age 50 beginning to decrease sebaceous gland secretion. The sebum secretion rate is higher in men than in women, and this difference decreases with age.
2.2 endocrine secretion
Sebaceous gland hyperactivity is mainly associated with imbalance of sex hormone secretion. Sebaceous glands are the target organs for androgens. Testosterone increases sebaceous gland volume and secretion. Especially, the 5 alpha-reductase is over-active in the human body endothelial lipid synthesis catalyst, so that the secretion of the dihydrotestosterone is increased, and the sebaceous gland is promoted to be abnormally increased. Therefore, the skin of general men is more oily than that of women, and pores are large, so that genetic factors also exist.
The mechanism of action of androgens: most of the circulating testosterone is bound to sex hormone binding protein, only 1% -2% is free, and the part enters sebaceous gland cells to influence the functions of the testosterone. Dehydroepiandrosterone and androstenedione secreted by the adrenal glands, other androgens in the circulation, may also enter sebaceous gland cells and be converted into testosterone for action. Testosterone entering the sebaceous gland is converted into 5 alpha-dihydrotestosterone by intracellular 5 alpha-reductase, then is combined with steroid cells in cytoplasm, enters nucleus and is combined with chromatin. Through up-regulation, the sterol regulatory factor binding protein pathway is activated to influence DNA transcription, and the action of promoting proliferation, differentiation and secretion of sebaceous gland cells is achieved.
2.3 diet and Nutrition
Low calorie food can rapidly reduce sebum secretion rate, change sebum composition, increase squalene proportion, and decrease other components proportion. When obese people eat low calorie foods, the urine levels of DHEA and testosterone decrease. Thus, dietary changes affect sebaceous gland function, and oily and spicy foods and high-calorie foods can increase sebaceous gland secretion.
2.4 other factors
The secretion of sebaceous glands does not change along with the change of seasons, but the sweat on the surface of the skin is increased when the weather is hot, so that the surface tension of the skin is changed, and the sebum is more easily distributed on the face, so that the skin looks more greasy. Infrared rays and ultraviolet rays in sunlight enter hair follicles, and can directly stimulate glands to be active after contacting sebaceous glands, so that abnormal oil secretion is caused.
In addition, the moisture content of the skin surface can affect the secretory diffusion of sebum. When the skin surface has high moisture, sebum emulsifies and diffusion becomes slow. Sebaceous glands are abnormally active when the skin is in a drier environment for a long period of time. If a part of human bodies are in a dry environment in winter, abnormal oil production and whelk frequently occur.
Disclosure of Invention
In order to solve the above problems of the prior art, the present invention aims to provide a balanced fat composition and an oil-controlling gel thereof by inhibiting 5 α -reductase activity.
The technical scheme adopted by the invention is as follows: the balanced grease composition for inhibiting the activity of 5 alpha-reductase and the oil control gel thereof comprise a solvent, a thickener, a humectant, a preservative, a corrosion agent, a pH regulator and the balanced grease composition, and the preparation method of the preparation comprises the following steps:
s1, accurately weighing each component material in the formula components, and cleaning production equipment;
s2, adding the solvent, the humectant and the thickener into an emulsifying pot, stirring and heating to 85-90 ℃, starting a homogenizer for homogenizing for 3-5 minutes, completely dissolving, and sterilizing at constant temperature for 10 min;
s3, stirring and cooling to 70-75 ℃, adding the preservative, stirring for 3 minutes, vacuumizing, keeping the temperature and defoaming completely;
s4, cooling to 40-45 deg.C under stirring, sequentially adding pH regulator, ester-forming agent, and acne muscle conditioning composition, and stirring.
Furthermore, the preparation comprises 72.5-93.25 parts of solvent, 0.1-1 part of thickener, 5-10 parts of humectant, 0.5-3 parts of preservative, 0.1-3 parts of fat decomposing agent, 0.05-0.5 part of PH regulator and 1-10 parts of balanced fat composition.
Furthermore, the preparation comprises the components of 83.5 parts of solvent, 1 part of thickener, 5 parts of humectant, 1 part of preservative, 1 part of fat-reducing agent, 0.5 part of PH regulator and 8 parts of balanced grease composition.
Furthermore, the preparation comprises 72.5 parts of solvent, 1 part of thickener, 10 parts of humectant, 3 parts of preservative, 3 parts of fat-reducing agent, 0.5 part of PH regulator and 10 parts of balanced grease composition.
Further, the thickening agent comprises polyacrylate cross-linked polymer-6, transparent xanthan gum, sodium hyaluronate, sodium polyglutamate, hydroxyethyl cellulose, carrageenan, tara gum, sodium polyacrylate and carbomer.
Further, the humectant comprises glycerin, propylene glycol, butylene glycol, dipropylene glycol, trehalose, and betaine.
Further, the preservative comprises 1, 2-pentanediol, p-hydroxyacetophenone, 1, 2-hexanediol, caprylic hydroxamic acid, phenoxyethanol and caprylic acid ester.
Further, the ester-forming agent comprises methyl glucitol polyether-20 and PEG/PPG-17/6 copolymer.
Further, the pH regulator comprises arginine, triethanolamine, tetrahydroxypropyl ethylenediamine and sodium hydroxide.
Further, the balanced oil composition comprises water, butylene glycol, an extract of the bark of the green flower of the tomato, caryophyllin, azelaic acid amide MEA, and nicotinamide.
The invention has the beneficial effects that:
the invention provides a balanced grease composition for inhibiting 5 alpha-reductase activity and an oil control gel thereof, wherein the components of the composition are green flower Ennan tomato bark extract sebaceous gland grease secretion, 5 alpha-reductase plays a decisive role, the green flower Ennan tomato bark extract regulates the sebaceous gland grease excessive secretion by inhibiting the activity of the 5 alpha-reductase, and the 5 alpha-reductase activity is inhibited by caryophyllin.
Nonane diamide MEA (MEA) is a sebum balancing agent, and is suitable for nursing oily and seborrheic skin. It can act together with vitamin B6 and zinc, is an inhibitor of 5-alpha reductase, has whitening effect, can be used for whitening skin for treating mottle and chloasma in pregnancy, can be used for treating sore including drug-induced acne, acne caused by cosmetics, acne caused by friction, and the like, and can be used for exfoliating dead skin, treating rosacea (erythema and rosacea) and being used as deodorant.
Nicotinamide: nicotinamide is used as one of B vitamins, has high safety and stable property, is not easily damaged by acid, alkali or heat, can keep the energy balance of skin, can recover cell energy and accelerate the synthesis of collagen, thereby avoiding the melanin transpigmentation of the skin caused by the thinning of horny layer due to low oil content, promotes the shedding of corneocytes by accelerating the renewal of the skin, promotes the synthesis of epidermal protein, enhances the self defense capacity of the skin, increases the water content of the skin, and has the functions of expanding blood vessels and promoting blood circulation when entering the human body to be mutually converted with nicotinic acid. Therefore, the nicotinamide can promote blood microcirculation of hair follicles, regulate oil secretion and realize water-oil balance.
Detailed Description
The present invention is further illustrated below with reference to specific examples.
Example 1:
the embodiment provides a balanced grease composition for inhibiting 5 alpha-reductase activity and an oil-control gel thereof, wherein the preparation comprises a solvent (83.5 parts), a thickener (1 part), a humectant (5 parts), a preservative (1 part), a corrosion agent (1 part), a pH regulator (0.5 part) and the balanced grease composition (8 parts), and the preparation method of the preparation comprises the following steps: s1, accurately weighing each component material in the formula components, and cleaning production equipment; s2, adding the solvent, the humectant and the thickener into an emulsifying pot, stirring and heating to 85-90 ℃, starting a homogenizer for homogenizing for 3-5 minutes, completely dissolving, and sterilizing at constant temperature for 10 min; s3, stirring and cooling to 70-75 ℃, adding the preservative, stirring for 3 minutes, vacuumizing, keeping the temperature and defoaming completely; s4, cooling to 40-45 deg.C under stirring, sequentially adding pH regulator, ester-forming agent, and acne muscle conditioning composition, and stirring.
Specifically, the thickening agent comprises polyacrylate cross-linked polymer-6, transparent xanthan gum, sodium hyaluronate, sodium polyglutamate, hydroxyethyl cellulose, carrageenan, tara gum, sodium polyacrylate and carbomer, the humectant comprises glycerol, propylene glycol, butanediol, dipropylene glycol, trehalose and betaine, the preservative comprises 1, 2-pentanediol, p-hydroxyacetophenone, 1, 2-hexanediol, caprylyl hydroximic acid, phenoxyethanol and glyceryl caprylate, the excipient comprises methyl glucitol polyether-20 and PEG/PPG-17/6 copolymer, the pH regulator comprises arginine, triethanolamine, tetrahydroxypropyl ethylenediamine and sodium hydroxide, the balanced grease composition comprises water, butanediol, ryegran southern tomato bark extract, caryophyllin and nonanodiamide MEA (MEA), Nicotinamide.
Example two:
the formulation ratio in this embodiment is substantially the same as that in the first embodiment, but the difference is that: the balanced grease composition for inhibiting the activity of 5 alpha-reductase and the oil-control gel thereof comprise a preparation which comprises a solvent (72.5 parts), a thickener (1 part), a humectant (10 parts), a preservative (3 parts), a corrosion agent (3 parts), a pH regulator (0.5 part) and the balanced grease composition (10 parts), and the preparation method of the preparation comprises the following steps:
s1, accurately weighing each component material in the formula components, and cleaning production equipment;
s2, adding the solvent, the humectant and the thickener into an emulsifying pot, stirring and heating to 85-90 ℃, starting a homogenizer for homogenizing for 3-5 minutes, completely dissolving, and sterilizing at constant temperature for 10 min;
s3, stirring and cooling to 70-75 ℃, adding the preservative, stirring for 3 minutes, vacuumizing, keeping the temperature and defoaming completely;
s4, cooling to 40-45 deg.C under stirring, sequentially adding pH regulator, ester-forming agent, and acne muscle conditioning composition, and stirring.
Specifically, the thickening agent comprises polyacrylate cross-linked polymer-6, transparent xanthan gum, sodium hyaluronate, sodium polyglutamate, hydroxyethyl cellulose, carrageenan, tara gum, sodium polyacrylate and carbomer, the humectant comprises glycerol, propylene glycol, butanediol, dipropylene glycol, trehalose and betaine, the preservative comprises 1, 2-pentanediol, p-hydroxyacetophenone, 1, 2-hexanediol, caprylyl hydroximic acid, phenoxyethanol and glyceryl caprylate, the excipient comprises methyl glucitol polyether-20 and PEG/PPG-17/6 copolymer, the pH regulator comprises arginine, triethanolamine, tetrahydroxypropyl ethylenediamine and sodium hydroxide, the balanced grease composition comprises water, butanediol, ryegran southern tomato bark extract, caryophyllin and nonanodiamide MEA (MEA), Nicotinamide.
The present invention is not limited to the above-described alternative embodiments, and various other forms of products can be obtained by anyone in light of the present invention. The above detailed description should not be taken as limiting the scope of the invention, which is defined in the claims, and which the description is intended to be interpreted accordingly.
Claims (10)
1. A balanced oil composition for inhibiting the activity of 5 alpha-reductase and an oil control gel thereof are characterized in that: the preparation method comprises the following steps:
s1, accurately weighing each component material in the formula components, and cleaning production equipment;
s2, adding the solvent, the humectant and the thickener into an emulsifying pot, stirring and heating to 85-90 ℃, starting a homogenizer for homogenizing for 3-5 minutes, completely dissolving, and sterilizing at constant temperature for 10 min;
s3, stirring and cooling to 70-75 ℃, adding the preservative, stirring for 3 minutes, vacuumizing, keeping the temperature and defoaming completely;
s4, cooling to 40-45 deg.C under stirring, sequentially adding pH regulator, ester-forming agent, and acne muscle conditioning composition, and stirring.
2. The balanced oil composition and oil control gel thereof for inhibiting the activity of 5 alpha-reductase according to claim 1, wherein: the preparation comprises 72.5-93.25 parts of solvent, 0.1-1 part of thickener, 5-10 parts of humectant, 0.5-3 parts of preservative, 0.1-3 parts of fat-reducing agent, 0.05-0.5 part of PH regulator and 1-10 parts of balanced fat composition.
3. The balanced oil composition for inhibiting 5 alpha-reductase activity and the oil control gel thereof according to claim 2, wherein: the preparation comprises the components of solvent (83.5 parts), thickener (1 part), humectant (5 parts), preservative (1 part), corrosion-resistant agent (1 part), pH regulator (0.5 part) and balanced grease composition (8 parts).
4. The balanced oil composition for inhibiting 5 alpha-reductase activity and the oil control gel thereof according to claim 2, wherein: the preparation comprises the components of 72.5 parts of solvent, 1 part of thickener, 10 parts of humectant, 3 parts of preservative, 3 parts of corrosion-resistant agent, 0.5 part of PH regulator and 10 parts of balanced grease composition.
5. The balanced oil composition and oil control gel thereof for inhibiting the activity of 5 alpha-reductase according to claim 1, wherein: the thickening agent comprises polyacrylate cross-linked polymer-6, transparent xanthan gum, sodium hyaluronate, sodium polyglutamate, hydroxyethyl cellulose, carrageenan, tara gum, sodium polyacrylate and carbomer.
6. The balanced oil composition and oil control gel thereof for inhibiting the activity of 5 alpha-reductase according to claim 1, wherein: the humectant comprises glycerin, propylene glycol, butanediol, dipropylene glycol, trehalose, and betaine.
7. The balanced oil composition and oil control gel thereof for inhibiting the activity of 5 alpha-reductase according to claim 1, wherein: the preservative comprises 1, 2-pentanediol, p-hydroxyacetophenone, 1, 2-hexanediol, caprylyl hydroxamic acid, phenoxyethanol and glyceryl caprylate.
8. The balanced oil composition and oil control gel thereof for inhibiting the activity of 5 alpha-reductase according to claim 1, wherein: the ester-forming agent comprises methyl glucitol polyether-20 and PEG/PPG-17/6 copolymer.
9. The balanced oil composition and oil control gel thereof for inhibiting the activity of 5 alpha-reductase according to claim 1, wherein: the pH regulator comprises arginine, triethanolamine, tetrahydroxypropylethylenediamine and sodium hydroxide.
10. The balanced oil composition and oil control gel thereof for inhibiting the activity of 5 alpha-reductase according to claim 1, wherein: the balanced oil composition comprises water, butanediol, extract of green flower Ennan tomato bark, caryophyllin, azelaic acid amide MEA, and nicotinamide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110915319.7A CN113520948A (en) | 2021-08-10 | 2021-08-10 | Balanced grease composition for inhibiting activity of 5 alpha-reductase and oil control gel thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110915319.7A CN113520948A (en) | 2021-08-10 | 2021-08-10 | Balanced grease composition for inhibiting activity of 5 alpha-reductase and oil control gel thereof |
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| CN113520948A true CN113520948A (en) | 2021-10-22 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114224766A (en) * | 2022-01-06 | 2022-03-25 | 广州科缇生物科技有限公司 | Oil control composition, application of oil control composition in cosmetics, cosmetics and preparation method of oil control composition |
| CN115381748A (en) * | 2022-09-21 | 2022-11-25 | 广州环亚化妆品科技股份有限公司 | Composition for controlling oil and relieving itching as well as preparation method and application thereof |
-
2021
- 2021-08-10 CN CN202110915319.7A patent/CN113520948A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114224766A (en) * | 2022-01-06 | 2022-03-25 | 广州科缇生物科技有限公司 | Oil control composition, application of oil control composition in cosmetics, cosmetics and preparation method of oil control composition |
| CN115381748A (en) * | 2022-09-21 | 2022-11-25 | 广州环亚化妆品科技股份有限公司 | Composition for controlling oil and relieving itching as well as preparation method and application thereof |
| CN115381748B (en) * | 2022-09-21 | 2023-10-31 | 广州环亚化妆品科技股份有限公司 | Oil-control itching-relieving composition and preparation method and application thereof |
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