CN115381748A - Composition for controlling oil and relieving itching as well as preparation method and application thereof - Google Patents
Composition for controlling oil and relieving itching as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN115381748A CN115381748A CN202211150301.3A CN202211150301A CN115381748A CN 115381748 A CN115381748 A CN 115381748A CN 202211150301 A CN202211150301 A CN 202211150301A CN 115381748 A CN115381748 A CN 115381748A
- Authority
- CN
- China
- Prior art keywords
- composition
- parts
- oil
- arginine
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 136
- 208000003251 Pruritus Diseases 0.000 title claims abstract description 70
- 230000007803 itching Effects 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 94
- 239000000284 extract Substances 0.000 claims abstract description 59
- 239000004475 Arginine Substances 0.000 claims abstract description 52
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 52
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 48
- 108010020346 Polyglutamic Acid Proteins 0.000 claims abstract description 48
- 239000011734 sodium Substances 0.000 claims abstract description 48
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 48
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims abstract description 47
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 27
- 239000003961 penetration enhancing agent Substances 0.000 claims abstract description 24
- 239000002453 shampoo Substances 0.000 claims abstract description 24
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims abstract description 20
- 239000002537 cosmetic Substances 0.000 claims abstract description 7
- 229920005862 polyol Polymers 0.000 claims abstract description 7
- 150000003077 polyols Chemical class 0.000 claims abstract description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 54
- 238000002156 mixing Methods 0.000 claims description 39
- 238000010438 heat treatment Methods 0.000 claims description 34
- 239000006185 dispersion Substances 0.000 claims description 27
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 23
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 23
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 23
- 229940068977 polysorbate 20 Drugs 0.000 claims description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 14
- 210000000582 semen Anatomy 0.000 claims description 13
- VLDFMKOUUQYFGF-UHFFFAOYSA-N 4-(butoxymethyl)-2-methoxyphenol Chemical compound CCCCOCC1=CC=C(O)C(OC)=C1 VLDFMKOUUQYFGF-UHFFFAOYSA-N 0.000 claims description 11
- 229940078465 vanillyl butyl ether Drugs 0.000 claims description 11
- 150000005846 sugar alcohols Polymers 0.000 claims description 7
- 239000001243 zingiber officinale rosc. root absolute Substances 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
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- 239000002612 dispersion medium Substances 0.000 claims description 2
- 229960004756 ethanol Drugs 0.000 claims description 2
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- 210000004761 scalp Anatomy 0.000 abstract description 19
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- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 29
- 230000001276 controlling effect Effects 0.000 description 29
- 229960005323 phenoxyethanol Drugs 0.000 description 29
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 24
- 238000003756 stirring Methods 0.000 description 22
- 238000012360 testing method Methods 0.000 description 22
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 15
- 150000002148 esters Chemical class 0.000 description 13
- 238000000034 method Methods 0.000 description 13
- XOBKSJJDNFUZPF-UHFFFAOYSA-N Methoxyethane Chemical compound CCOC XOBKSJJDNFUZPF-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 210000003491 skin Anatomy 0.000 description 11
- 239000008367 deionised water Substances 0.000 description 10
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- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 9
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 9
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- NKJOXAZJBOMXID-UHFFFAOYSA-N 1,1'-Oxybisoctane Chemical compound CCCCCCCCOCCCCCCCC NKJOXAZJBOMXID-UHFFFAOYSA-N 0.000 description 8
- 241000186427 Cutibacterium acnes Species 0.000 description 8
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 description 8
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 8
- 229940073499 decyl glucoside Drugs 0.000 description 8
- 238000000265 homogenisation Methods 0.000 description 8
- 229940055019 propionibacterium acne Drugs 0.000 description 8
- 210000001732 sebaceous gland Anatomy 0.000 description 8
- 238000010008 shearing Methods 0.000 description 8
- 239000001509 sodium citrate Substances 0.000 description 8
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 8
- 229940057950 sodium laureth sulfate Drugs 0.000 description 8
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 8
- 239000004006 olive oil Substances 0.000 description 7
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- 239000003755 preservative agent Substances 0.000 description 7
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- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 6
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- 230000014509 gene expression Effects 0.000 description 6
- 230000002195 synergetic effect Effects 0.000 description 6
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 5
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
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- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
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- SXAMGRAIZSSWIH-UHFFFAOYSA-N 2-[3-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,2,4-oxadiazol-5-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1=NOC(=N1)CC(=O)N1CC2=C(CC1)NN=N2 SXAMGRAIZSSWIH-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
The invention belongs to the technical field of cosmetics, and discloses an oil-control and itching-relieving composition, and a preparation method and application thereof. The composition comprises arginine, sodium polyglutamate, pea extract, penetration enhancer and emulsifier. The oil-in-water nano-scale composition dispersoid is prepared by taking arginine, sodium polyglutamate and pea extract as effective active ingredients and combining a penetration enhancer, an emulsifier, a polyol solvent and the effective active ingredients, and can play double roles of oil control and itching relieving. The composition has mild and non-irritant effects, high safety, and good stability. The oil-controlling and itching-relieving composition provided by the invention is applied to shampoo and essence, can effectively reduce scalp sebum secretion, relieve symptoms such as scalp redness and itching and has a good nursing effect on scalp.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an oil-controlling and itching-relieving composition, and a preparation method and application thereof.
Background
Skin lipids are mainly derived from two parts: keratinocytes and sebaceous glands. Lipids derived from sebaceous glands are mainly composed of squalene, wax lipids, triglycerides, cholesterol esters, cholesterol. When the production and the demand of lipid reach balance, the skin is comfortable, moist and clean, and when the lipid is excessive, the skin feels uncomfortable and greasy, and seborrheic dermatitis or acne is easy to appear. The density of sebaceous glands on the scalp is about 144-192 sebaceous glands/cm in terms of the number of sebaceous glands 2 About 52-79 pieces/cm on forehead 2 About 42-78 pieces/cm on cheek 2 . From the density of sebaceous glands, the scalp has high density of sebaceous glands, oil is easy to be produced, and the lipid secreted by the scalp is about 288 mug/cm within 12 hours 2 And the lipid of forehead is about 144. Mu.g/cm 2 . The oxidation and rancidity of lipid secreted from the scalp can stimulate the scalp and cause scalp itching; the excessively secreted lipids also provide a good living environment for microorganisms such as malassezia, which causes an imbalance in the scalp microbial flora and is likely to cause symptoms such as dandruff.
At present, the types of raw materials for controlling oil and relieving itching in cosmetics are various, such as witch hazel, calendula, lavender and the like for shrinking pores; talc powder, kaolin, etc. for physical oil absorption; glycyrrhrizae radix extract and bisabolol for relieving inflammation. However, the plant extracts have complex components, the stability of the efficacy among batches is difficult to ensure, and the efficacy mechanism is not clear; the components such as talcum powder, kaolin and the like are not suitable for formulation products such as shampoo, hair conditioner and the like.
Therefore, it is highly desirable to provide an oil-controlling and itching-relieving composition, which can effectively control oil and relieve itching and is used for cleaning and caring scalp.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art described above. Therefore, the oil-control and itching-relieving composition provided by the invention can effectively reduce sebum secretion of scalp, relieve symptoms such as redness and pruritus of scalp and has good cleaning and nursing effects on scalp.
In a first aspect, the invention provides a composition for controlling oil and relieving itching.
Specifically, the composition for controlling oil and relieving itching comprises arginine, sodium polyglutamate, pea extract, a penetration enhancer and an emulsifier.
Preferably, the composition comprises the following components in parts by weight: 0.1-20 parts of arginine, 0.1-10 parts of sodium polyglutamate, 0.1-20 parts of pea extract, 0.1-15 parts of penetration enhancer and 0.1-15 parts of emulsifier.
Further preferably, the composition comprises the following components in parts by weight: 0.5-10 parts of arginine, 0.1-5 parts of sodium polyglutamate, 0.1-15 parts of pea extract, 0.1-10 parts of penetration enhancer and 0.2-10 parts of emulsifier.
Preferably, the penetration enhancer is at least one selected from vanillyl butyl ether, ethanol, ginger root extract and ginger root oil. When the penetration enhancer is a mixture, the invention has no limitation on the weight percentage of each substance in the penetration enhancer mixture.
Preferably, the emulsifier is an amphiphilic emulsifier.
Preferably, the emulsifier comprises polysorbate-20.
Further preferably, the emulsifier further comprises at least one of sucrose dilaurate, olive oil PEG-7 esters, PEG-7 glyceryl cocoate. When the emulsifier is a mixture, the present invention is not limited to the weight percentages of each material in the emulsifier mixture.
Preferably, the composition further comprises a polyol and water.
Preferably, the polyhydric alcohol is selected from at least one of glycerol, butylene glycol, 1, 3-propanediol, propylene glycol. It should be noted that, when the polyol is a mixture of polyols, the present invention has no limitation on the weight percentage of each substance in the mixture, and the substances may be mixed in any proportion.
Preferably, the composition comprises the following components in parts by weight: 0.1-20 parts of arginine, 0.1-10 parts of sodium polyglutamate, 0.1-20 parts of pea extract, 0.1-10 parts of penetration enhancer, 0.1-15 parts of emulsifier, 1-30 parts of polyalcohol and 0.5-100 parts of water.
Further preferably, the composition comprises the following components in parts by weight: 0.5-10 parts of arginine, 0.1-5 parts of sodium polyglutamate, 0.1-15 parts of pea extract, 0.1-10 parts of penetration enhancer, 0.2-10 parts of emulsifier, 10-30 parts of solvent and 1.8-88.6 parts of water.
Preferably, the composition further comprises a preservative. Preferably, the preservative is 0.2-2 parts by weight; further preferably, the preservative is 0.4 to 1.8 parts by weight.
Preferably, the preservative is selected from at least one of phenoxyethanol, p-hydroxyacetophenone, ethylhexyl glycerol and sodium benzoate. When the preservative is a mixture, the invention has no limitation on the weight percentage of each substance in the mixture, and the substances can be mixed in any proportion, but the preservative is required to meet the requirements of relevant laws and regulations.
Preferably, the composition is a nanoscale dispersion comprising a dispersed phase and a dispersion medium. The particle size of the dispersed phase is 100-800nm.
Preferably, the Zeta potential of the composition is from-60 to-20 mV; further preferably, the Zeta potential of the composition is from-60 to-35 mV.
In a second aspect, the invention provides a preparation method of the composition for controlling oil and relieving itching.
Specifically, the preparation method of the oil-controlling and itching-relieving composition comprises the following steps:
mixing water, arginine, sodium polyglutamate, semen Pisi Sativi extract and polyalcohol, and heating to obtain water phase; mixing penetration enhancer and emulsifier, and heating to obtain oil phase; and mixing the oil phase and the water phase, and homogenizing under high pressure to obtain the oil-controlling and itching-relieving composition.
Preferably, the heating during the preparation of the aqueous phase is water bath heating; the temperature of the water bath heating is 50-80 ℃, and the time of the water bath heating is 10-30min.
Preferably, the heating during the preparation of the oil phase is water bath heating; the temperature of the water bath heating is 50-80 ℃, and the time of the water bath heating is 10-30min.
Preferably, the pressure of the high-pressure homogenization is 200-1200bar, the shear rate of the high-pressure homogenization is 1000-5000rpm, and the time of the high-pressure homogenization is 1-10min.
Preferably, the high pressure homogenization is preceded by atmospheric homogenization to produce a micron-sized dispersion. The shearing rate of the normal pressure homogenization is 100-1000rpm, and the time of the normal pressure homogenization is 5-15min.
More specifically, the preparation method of the oil-controlling and itching-relieving composition comprises the following steps:
mixing water, arginine, sodium polyglutamate, semen Pisi Sativi extract, and polyalcohol solvent, stirring, and heating in water bath at 50-80 deg.C for 10-30min to obtain water phase; mixing penetration enhancer and emulsifier, stirring, and heating in water bath at 50-80 deg.C for 10-30min to obtain oil phase; then mixing the oil phase and the water phase, adding a preservative, and carrying out normal-pressure homogenization for 5-15min at a shear rate of 100-1000rpm to prepare a micron-sized dispersion; homogenizing the prepared micron-sized dispersion at high pressure of 200-1200bar and at a shear rate of 1000-5000rpm for 1-10min to prepare the oil-controlling and itching-relieving composition.
In the third aspect of the invention, the application of the composition for controlling oil and relieving itching is provided.
In particular to application of the composition for controlling oil and relieving itching in preparing cosmetics.
A cosmetic comprises the above oil-controlling and itching-relieving composition.
A shampoo comprises the oil-control and itching-relieving composition.
An essence comprises the oil-controlling and itching-relieving composition.
Arginine belongs to small molecular amino acid, has small molecular weight and better permeability, and researches show that the arginine can reduce sebum secretion and has a certain oil control effect, but because arginine is a hydrophilic substance, the arginine is limited by the structure when penetrating through the stratum corneum. Sodium polyglutamate belongs to macromolecular hydrophilic substances, can repair skin barriers and has the moisture-preserving effect, but is difficult to permeate through cuticle. The pea extract contains abundant polyphenol and polysaccharide substances, and has effects of relieving skin and resisting inflammation. Researches find that the three effective active ingredients have synergistic effect on inhibiting the expression of propionibacterium acnes and COX-2 (cyclooxygenase-2) and inflammatory factors. The invention skillfully fuses the three functional active ingredients with amphiphilic emulsifier, penetration enhancer and polyalcohol which have good skin-friendly property, and the prepared encapsulated nano-scale composition dispersoid has small particle size of dispersed phase and is easier to penetrate through cuticle, thereby playing the roles of controlling oil, relieving itching, cleaning and nursing scalp.
In addition, the penetration enhancer has certain damage effect on the skin barrier, and the nano-scale composition dispersion is prepared by adopting a mode of coating the penetration enhancer by the emulsifier, so that the irritation of the penetration enhancer on the skin can be effectively reduced.
Compared with the prior art, the invention has the following beneficial effects:
(1) The oil-in-water nano-scale composition dispersion is prepared by taking arginine, sodium polyglutamate and pea extract as effective active ingredients and combining a penetration enhancer, an emulsifier, a polyol solvent and the effective active ingredients, so that the effective active ingredients which have strong hydrophilicity and large molecular weight and are difficult to penetrate through skin cuticle can be delivered transdermally, the three effective active ingredients are synergistic, the dual effects of oil control and itching relieving are achieved, the three effective active ingredients are retained and slowly released in the skin for a long time, and the bioavailability of the composition is improved.
(2) The oil-control itching-relieving composition provided by the invention is mild, non-irritant and high in safety; and the particle size and Zeta potential are not obviously changed after being placed at high temperature (40 ℃) and room temperature for 1 month, and the stability is good.
(3) The oil-controlling and itching-relieving composition provided by the invention is applied to shampoo and essence, can effectively reduce scalp sebum secretion, relieve symptoms such as scalp redness and itching and has good cleaning and nursing effects on scalp.
Detailed Description
In order to make the technical solutions of the present invention more clearly apparent to those skilled in the art, the following examples are given for illustration. It should be noted that the following examples are not intended to limit the scope of the claimed invention.
The starting materials, reagents or apparatuses used in the following examples are conventionally commercially available or can be obtained by conventionally known methods, unless otherwise specified.
Example 1
The composition for controlling oil and relieving itching comprises the following components in parts by weight:
0.5 part of arginine, 0.1 part of sodium polyglutamate, 0.1 part of pea extract, 0.1 part of vanillyl butyl ether, 0.1 part of polysorbate-20, 0.1 part of sucrose dilaurate, 10 parts of glycerol, 0.2 part of phenoxyethanol, 0.2 part of p-hydroxyacetophenone and the balance of water.
A preparation method of a composition for controlling oil and relieving itching comprises the following steps:
mixing water, arginine, sodium polyglutamate, semen Pisi Sativi extract, and glycerol, stirring, heating in water bath at 50 deg.C for 10min to obtain water phase; mixing vanillyl butyl ether, polysorbate-20 and sucrose dilaurate, stirring uniformly, and heating in water bath at 50 deg.C for 10min to obtain oil phase; mixing the oil phase and the water phase, adding phenoxyethanol and p-hydroxyacetophenone, and homogenizing at 50 ℃ and a shear rate of 100rpm under normal pressure for 5min to obtain a micron-sized dispersion; and finally, homogenizing the obtained micron-sized dispersion for 1min under the conditions of the pressure of 200bar and the shearing rate of 1000rpm to obtain the nanoscale composition.
Example 2
The composition for controlling oil and relieving itching comprises the following components in parts by weight:
1 part of arginine, 0.5 part of sodium polyglutamate, 0.5 part of pea extract, 2 parts of vanillyl butyl ether, 205 parts of polysorbate-205 parts, 5 parts of sucrose dilaurate, 15 parts of glycerol, 0.5 part of phenoxyethanol, 0.5 part of p-hydroxyacetophenone and the balance of water.
A preparation method of a composition for controlling oil and relieving itching comprises the following steps:
mixing water, arginine, sodium polyglutamate, semen Pisi Sativi extract, and glycerol, stirring, heating in water bath at 50 deg.C for 10min to obtain water phase; mixing and stirring vanillyl butyl ether, polysorbate-20 and sucrose dilaurate uniformly, and heating in water bath at 50 deg.C for 10min to obtain oil phase; mixing the oil phase and the water phase, adding phenoxyethanol and p-hydroxyacetophenone, and homogenizing at 50 ℃ and a shear rate of 100rpm under normal pressure for 5min to obtain a micron-sized dispersion; and finally, homogenizing the obtained micron-sized dispersion for 1min under the conditions of the pressure of 200bar and the shear rate of 1000rpm to obtain the nanoscale composition.
Example 3
The composition for controlling oil and relieving itching comprises the following components in parts by weight:
1 part of arginine, 0.5 part of sodium polyglutamate, 2 parts of pea extract, 10 parts of vanillyl butyl ether, 205 parts of polysorbate-205 parts, 5 parts of sucrose dilaurate, 30 parts of glycerol, 1.0 part of phenoxyethanol, 0.8 part of p-hydroxyacetophenone and the balance of water.
A preparation method of a composition for controlling oil and relieving itching comprises the following steps:
mixing water, arginine, sodium polyglutamate, semen Pisi Sativi extract, and glycerol, stirring, heating in water bath at 50 deg.C for 10min to obtain water phase; mixing and stirring vanillyl butyl ether, polysorbate-20 and sucrose dilaurate uniformly, and heating in water bath at 50 deg.C for 10min to obtain oil phase; mixing the oil phase and the water phase, adding phenoxyethanol and p-hydroxyacetophenone, and homogenizing at 50 ℃ and a shear rate of 100rpm under normal pressure for 5min to obtain a micron-sized dispersion; and finally, homogenizing the obtained micron-sized dispersion for 1min under the conditions of the pressure of 200bar and the shear rate of 1000rpm to obtain the nanoscale composition.
Example 4
The composition for controlling oil and relieving itching comprises the following components in parts by weight:
1 part of arginine, 1 part of sodium polyglutamate, 5 parts of pea extract, 10 parts of vanillyl butyl ether, 5 parts of polysorbate-20, 5 parts of sucrose dilaurate, 30 parts of glycerol, 1.0 part of phenoxyethanol, 0.8 part of p-hydroxyacetophenone and the balance of water.
A preparation method of a composition for controlling oil and relieving itching comprises the following steps:
mixing water, arginine, sodium polyglutamate, semen Pisi Sativi extract, and glycerol, stirring, heating in water bath at 50 deg.C for 10min to obtain water phase; mixing vanillyl butyl ether, polysorbate-20 and sucrose dilaurate, stirring uniformly, and heating in water bath at 50 deg.C for 10min to obtain oil phase; mixing the oil phase and the water phase, adding phenoxyethanol and p-hydroxyacetophenone, and homogenizing at 50 ℃ and a shear rate of 100rpm under normal pressure for 5min to obtain a micron-sized dispersion; and finally, homogenizing the obtained micron-sized dispersion for 1min under the conditions of the pressure of 200bar and the shear rate of 1000rpm to obtain the nanoscale composition.
Example 5
The composition for controlling oil and relieving itching comprises the following components in parts by weight:
2 parts of arginine, 1 part of sodium polyglutamate, 10 parts of pea extract, 1 part of ethanol, 0.1 part of polysorbate-20, 0.5 part of olive oil PEG-7 esters, 5 parts of glycerol, 0.3 part of phenoxyethanol, 0.5 part of p-hydroxyacetophenone and the balance of water.
A preparation method of the composition for controlling oil and relieving itching comprises the following steps:
mixing water, arginine, sodium polyglutamate, semen Pisi Sativi extract, and glycerol, stirring, and heating in water bath at 80 deg.C for 10min to obtain water phase; mixing ethanol, polysorbate-20, and oleum Olivarum PEG-7 esters, stirring, and heating in water bath at 80 deg.C for 10min to obtain oil phase; mixing the oil phase and the water phase, adding phenoxyethanol and p-hydroxyacetophenone, and homogenizing at 80 ℃ and a shear rate of 100rpm under normal pressure for 5min to obtain a micron-sized dispersion; and finally, homogenizing the obtained micron-sized dispersion for 1min under the conditions of the pressure of 200bar and the shearing rate of 1000rpm to obtain the nanoscale composition.
Example 6
The composition for controlling oil and relieving itching comprises the following components in parts by weight:
2 parts of arginine, 2 parts of sodium polyglutamate, 15 parts of pea extract, 1 part of ginger root extract, 1.0 part of polysorbate-20, 1.0 part of olive oil PEG-7 esters, 5 parts of glycerol, 0.3 part of phenoxyethanol, 0.5 part of p-hydroxyacetophenone and the balance of water.
A preparation method of a composition for controlling oil and relieving itching comprises the following steps:
mixing water, arginine, sodium polyglutamate, semen Pisi Sativi extract, and glycerol, stirring, heating in water bath at 80 deg.C, and keeping the temperature for 30min to obtain water phase; mixing rhizoma Zingiberis recens extract, polysorbate-20, and oleum Olivarum PEG-7 esters, stirring, and heating in water bath at 80 deg.C for 30min to obtain oil phase; mixing the oil phase and the water phase, adding phenoxyethanol and p-hydroxyacetophenone, and homogenizing at 80 ℃ and normal pressure at a shear rate of 100rpm for 15min to obtain a micron-sized dispersion; and finally, homogenizing the obtained micron-sized dispersion for 10min under the conditions of the pressure of 200bar and the shearing rate of 1000rpm to obtain the nanoscale composition.
Example 7
The composition for controlling oil and relieving itching comprises the following components in parts by weight:
2 parts of arginine, 4 parts of sodium polyglutamate, 10 parts of pea extract, 1 part of ginger root extract, 1.0 part of polysorbate-20, 1.0 part of olive oil PEG-7 esters, 5 parts of glycerol, 0.3 part of phenoxyethanol, 0.5 part of p-hydroxyacetophenone and the balance of water.
A preparation method of a composition for controlling oil and relieving itching comprises the following steps:
mixing water, arginine, sodium polyglutamate, semen Pisi Sativi extract, and glycerol, stirring, heating in water bath at 80 deg.C, and keeping the temperature for 30min to obtain water phase; mixing rhizoma Zingiberis recens extract, polysorbate-20, and oleum Olivarum PEG-7 esters, stirring, and heating in water bath at 80 deg.C for 30min to obtain oil phase; mixing the oil phase and the water phase, adding phenoxyethanol and p-hydroxyacetophenone, and homogenizing at 80 ℃ and normal pressure at a shear rate of 1000rpm for 15min to obtain a micron-sized dispersion; and finally, homogenizing the obtained micron-sized dispersion for 10min under the conditions that the pressure is 1200bar and the shearing rate is 5000rpm to obtain the nanoscale composition.
Example 8
The composition for controlling oil and relieving itching comprises the following components in parts by weight:
4 parts of arginine, 5 parts of sodium polyglutamate, 10 parts of pea extract, 10 parts of ginger root extract, 5.0 parts of polysorbate-20, 3.0 parts of olive oil PEG-7 esters, 10 parts of butanediol, 5 parts of 1, 3-propylene glycol, 0.5 part of phenoxyethanol, 0.8 part of ethylhexyl glycerol and the balance of water.
A preparation method of a composition for controlling oil and relieving itching comprises the following steps:
mixing water, arginine, sodium polyglutamate, semen Pisi Sativi extract, butanediol, and 1, 3-propylene glycol, stirring, heating in water bath at 70 deg.C, and keeping the temperature for 15min to obtain water phase; mixing rhizoma Zingiberis recens extract, polysorbate-20, and oleum Olivarum PEG-7 esters, stirring, and heating in water bath at 70 deg.C for 15min to obtain oil phase; mixing the oil phase and the water phase, adding phenoxyethanol and ethylhexyl glycerol, and homogenizing at 70 ℃ and normal pressure for 10min at a shear rate of 500rpm to obtain a micron-sized dispersion; and finally, homogenizing the obtained micron-sized dispersion for 5min under the conditions that the pressure is 600bar and the shearing rate is 3000rpm, thus obtaining the nanoscale composition.
Example 9
The composition for controlling oil and relieving itching comprises the following components in parts by weight:
8 parts of arginine, 0.5 part of sodium polyglutamate, 10 parts of pea extract, 1 part of ginger root extract, 5.0 parts of polysorbate-20, 1.0 part of olive oil PEG-7 esters, 1 part of glycerol, 5 parts of 1, 3-propylene glycol, 0.5 part of phenoxyethanol, 0.8 part of ethylhexyl glycerol and the balance of water.
A preparation method of a composition for controlling oil and relieving itching comprises the following steps:
mixing water, arginine, sodium polyglutamate, semen Pisi Sativi extract, glycerol, and 1, 3-propylene glycol, stirring, and heating in water bath at 70 deg.C for 15min to obtain water phase; mixing rhizoma Zingiberis recens extract, polysorbate-20, and oleum Olivarum PEG-7 esters, stirring, and heating in water bath at 70 deg.C for 15min to obtain oil phase; mixing the oil phase and the water phase, adding phenoxyethanol and ethylhexyl glycerol, and homogenizing at 70 ℃ and normal pressure for 10min at a shear rate of 500rpm to obtain a micron-sized dispersion; and finally, homogenizing the obtained micron-sized dispersion for 5min under the conditions that the pressure is 600bar and the shearing rate is 3000rpm, thus obtaining the nanoscale composition.
Example 10
The composition for controlling oil and relieving itching comprises the following components in parts by weight:
10 parts of arginine, 5 parts of sodium polyglutamate, 15 parts of pea extract, 10 parts of ginger root extract, 5.0 parts of polysorbate-20, 3 parts of olive oil PEG-7 esters, 10 parts of butanediol, 5 parts of 1, 3-propylene glycol, 0.5 part of phenoxyethanol and the balance of water.
A preparation method of the composition for controlling oil and relieving itching comprises the following steps:
mixing water, arginine, sodium polyglutamate, semen Pisi Sativi extract, butanediol, and 1, 3-propylene glycol, stirring, and heating in water bath at 70 deg.C for 15min to obtain water phase; mixing rhizoma Zingiberis recens extract, polysorbate-20, and oleum Olivarum PEG-7 esters, stirring, and heating in water bath at 70 deg.C for 15min to obtain oil phase; mixing the oil phase and the water phase, adding phenoxyethanol, and homogenizing at 70 ℃ and a shear rate of 500rpm under normal pressure for 10min to obtain a micron-sized dispersion; and finally, homogenizing the obtained micron-sized dispersion for 5min under the conditions that the pressure is 600bar and the shearing rate is 3000rpm, thus obtaining the nanoscale composition.
Comparative example 1
This comparative example provides a composition which differs from that of example 1 in that 0.5 parts of arginine are replaced by 0.2 parts of sodium polyglutamate and 0.3 parts of pea extract, i.e. no arginine is contained in the composition of this comparative example, 0.3 parts of sodium polyglutamate and 0.4 parts of pea extract. The remaining raw materials and preparation were the same as in example 1.
Comparative example 2
This comparative example provides a composition that differs from example 2 in that 0.5 parts of sodium polyglutamate is replaced with 0.2 parts of arginine and 0.3 parts of pea extract, i.e. sodium polyglutamate is not present in the composition of this comparative example, arginine is 1.2 parts, and pea extract is 0.8 parts. The rest of the raw materials and the preparation method are the same as example 2.
Comparative example 3
This comparative example provides a composition that differs from example 3 in that 2 parts of pea extract were replaced with 1 part arginine and 1 part sodium polyglutamate, i.e. the composition of this comparative example did not contain pea extract, 1.5 parts sodium polyglutamate and 2 parts arginine. The remaining raw materials and preparation were the same as in example 3.
Comparative example 4
This comparative example provides a composition which differs from example 4 in that it does not contain the penetration enhancer, vanillyl butyl ether, and the remaining components and preparation are the same as in example 4.
Comparative example 5
This comparative example provides a composition which differs from example 4 in that it does not contain the penetration enhancer ethanol, and the remaining components and method of preparation are the same as example 4.
Comparative example 6
This comparative example provides a composition which is different from example 4 in that polysorbate-20, an emulsifier, is not included, and the remaining components and the preparation method are the same as example 4.
Product effectiveness testing
(1) Stability test
The compositions obtained in examples 1 to 10 and comparative examples 1 to 6 were allowed to stand at room temperature and 40 ℃ for 1 month, and properties and particle diameters of the samples were examined before and after storage, respectively, to obtain experimental results.
Stability experiments show that the compositions provided by the embodiments 1-10 and the comparative examples 1-5 of the invention have no significant changes in particle size and Zeta potential after being placed at high temperature (40 ℃) and room temperature for 1 month, and the prepared nano-composition has good stability. However, in comparative example 6, in which polysorbate-20 was not added, delamination occurred at 1 week.
(2) Patch test
The compositions prepared in example 1, example 3, example 4, example 7, example 9 and comparative examples 1-3 were randomly selected for patch testing. The specific process is as follows:
a. the test substance: the oil-controlling and itching-relieving composition of the invention;
b. subject: a total of 30 men, 17 women, age 20-55 years, meeting the volunteer enrollment criteria of the subject;
c. the test method comprises the following steps: placing the tested object in a proper spot-sticking tester by adopting a closed test method, sticking the tested object on the arm curve side of the tested object by using a hypoallergenic adhesive tape, slightly pressing the tested object by using a palm to uniformly stick the tested object on the skin, and continuously applying the test object on the skin for 24 hours; the blank control group was subject without product;
d. and (4) observing results: the test devices were removed after 24 hours, skin reactions were observed after 0.5h, 24h, 48h, respectively, and the results were recorded. The grade of the adverse reaction of the skin is shown in Table 1, and the test results are shown in Table 2.
TABLE 1 skin closed Patch test skin response grading Standard
TABLE 2 test results of human skin patches
As can be seen from Table 2, the compositions provided by the examples and the comparative examples of the present invention have no adverse reaction in the test process, and have good mildness and high safety.
(3) Propionibacterium acnes inhibitory test
Propionibacterium acnes inhibitory experiments were conducted on the compositions prepared in examples 1-10 and comparative examples 1-6. The specific process is as follows:
before adding into 96-well plate, the Propionibacterium acnes liquid is diluted to the bacteria content of 1 × 10 5 CFU/mL. The Minimum Inhibitory Concentration (MIC) was determined by the liquid microdilution method. After the 96-well plate was placed in a 37 ℃ incubator for 24 hours, the test was performed to calculate an MIC value (minimum inhibitory concentration value).
The test results are shown in table 3.
TABLE 3
| Sample(s) | MIC value of Propionibacterium acnes [ mu ] g/mL |
| Example 1 | 39.3 |
| Example 2 | 28.7 |
| Example 3 | 24.1 |
| Example 4 | 17.7 |
| Example 5 | 15.6 |
| Example 6 | 17.9 |
| Example 7 | 13.2 |
| Example 8 | 9.6 |
| Example 9 | 12.4 |
| Example 10 | 18.7 |
| Comparative example 1 | 43.4 |
| Comparative example 2 | 30.8 |
| Comparative example 3 | 59.4 |
| Comparative example 4 | 18.3 |
| Comparative example 5 | 16.7 |
| Comparative example 6 | 17.9 |
Test results show that the composition for controlling oil and relieving itching, provided by the invention, has better inhibition effect on propionibacterium acnes in examples 1-10. Generally, in the range of 0.1-10 parts of pea extract, the content of the pea extract is increased, and the pea extract has certain enhancing effect on the propionibacterium acnes; in combination with comparative examples 1-3, it can be seen that sodium polyglutamate and arginine also have a synergistic effect on the composition, and in the absence of sodium polyglutamate, arginine or pea extract, the composition has a poor inhibitory effect on Propionibacterium acnes.
(4) COX-2 (cyclooxygenase-2) inhibitory assay
The compositions prepared in examples 1 to 10 and comparative examples 1 to 6 of the present invention were selected, and the compositions were cultured in the presence of 0.01% of primary human sebaceous gland cells for 24 hours, and then subjected to extraction, purification, reverse transcription of total RNA, etc., to calculate the expression level of COX-2 gene (RQ value: change in expression relative to the housekeeping gene GAPDH) produced by the compositions. The test results are shown in table 4.
TABLE 4
| Concentration of | RQ value | |
| Blank control group | 0 | 1 |
| Example 1 | 0.01％ | 0.75 |
| Example 2 | 0.01％ | 0.67 |
| Example 3 | 0.01％ | 0.63 |
| Example 4 | 0.01％ | 0.54 |
| Example 5 | 0.01％ | 0.41 |
| Example 6 | 0.01％ | 0.51 |
| Example 7 | 0.01％ | 0.32 |
| Example 8 | 0.01％ | 0.26 |
| Example 9 | 0.01％ | 0.3 |
| Example 10 | 0.01％ | 0.58 |
| Comparative example 1 | 0.01％ | 0.79 |
| Comparative example 2 | 0.01％ | 0.74 |
| Comparative example 3 | 0.01％ | 0.85 |
| Comparative example 4 | 0.01％ | 0.55 |
| Comparative example 5 | 0.01％ | 0.48 |
| Comparative example 6 | 0.01％ | 0.53 |
Test results show that 0.01% of examples 1-3 can down-regulate the expression rates of COX-2 genes involved in sebum secretion and inflammation to 25%,33% and 37%, respectively; comparative examples 1-3 down-regulated the expression rates of COX-2 genes involved in sebum secretion and inflammation in the absence of poly-sodium glutamate, arginine or pea extract at 21%,26%,15%, respectively. The sodium polyglutamate, arginine and pea extract have synergistic effect on the down-regulation of COX-2 gene expression involved in sebum secretion and inflammation.
(5) Inflammatory factor inhibitory assay
RAW264.7 mouse macrophages were adjusted to 1X 10 5 The cells were inoculated in 6-well plates at 2 mL/well and incubated in a cell incubator for 24h. After the original medium was discarded, 2mL of complete medium containing 5. Mu.g/mL of LPS and containing 5%, 10%, 12.5%, 16.67%, and 20% by mass of samples was added, and the culture was continued for 24 hours. Cell supernatants were collected and TNF-a content was determined by ELISA kit instructions. Each group is provided with three multiple holes. The samples were tested for inhibition of LPS-induced secretion of TNF-a, a macrophage inflammatory factor in RAW264.7 mice at a mass fraction of 10%. The test results are shown in table 5.
TABLE 5
Test results show that the composition for controlling oil and relieving itching provided by the invention has better inhibition effect on inflammatory factors in examples 1-10. Generally, in the range of 0.1-10 parts of pea extract, the content of the pea extract increases, and the pea extract has certain enhancing effect on inflammatory factors; in combination with comparative examples 1-3, it can be seen that sodium polyglutamate and arginine also have a synergistic effect on the composition, and in the absence of sodium polyglutamate, arginine or pea extract, the composition has a poor inhibitory effect on inflammatory factors.
Application example 1
The oil-controlling and itching-relieving composition prepared in example 7 was applied to shampoo. The method comprises the following specific steps:
the oil-control itching-relieving shampoo comprises the following components in percentage by weight: cocoamidopropyl betaine 10%, decyl glucoside 2%, sodium laureth sulfate 12%, polyquaternium-10.6%, PPG-3 octyl ether 0.5%, cocoamidomethyl MEA 3%, sodium benzoate 0.3%, phenoxyethanol 0.3%, sodium citrate 0.2%, citric acid 0.2%, disodium EDTA 0.1%, perfume 0.5%, the oil-controlling and itching-relieving composition prepared in example 7 1%, and the balance of deionized water.
Comparative application example 1
Comparative application example 1 the oil-controlling antipruritic composition prepared in example 7 was not added as a blank control. The specific formula is as follows:
the shampoo comprises the following components in percentage by weight: 10% of cocamidopropyl betaine, 2% of decyl glucoside, 12% of sodium laureth sulfate, 10.6% of polyquaternium, 0.5% of PPG-3 octyl ether, 3% of cocamidomethyl MEA (methyl Ethyl Ether), 0.3% of sodium benzoate, 0.3% of phenoxyethanol, 0.2% of sodium citrate, 0.2% of citric acid, 0.1% of disodium EDTA (ethylene diamine tetraacetic acid), 0.5% of essence and the balance of deionized water.
Application example 2
The oil-control itching-relieving composition prepared in example 7 is applied to essence, and specifically comprises the following components:
the oil-control itching-relieving essence consists of the following components in percentage by weight: 8% of butanediol, 5% of ethanol, 0.6% of 1, 2-hexanediol, 0.6% of p-hydroxyacetophenone, 0.06% of PEG-60 hydrogenated castor oil, 0.005% of lactic acid, 0.1% of disodium EDTA (ethylene diamine tetraacetic acid), 0.01% of essence, 0.5% of the oil-controlling and itching-relieving composition prepared in example 7, and the balance of deionized water.
Comparative application example 2
Comparative application example 2 the oil-controlling and itch-relieving composition prepared in example 7 was not added as a blank control. The specific formula is as follows:
the essence consists of the following components in percentage by weight: 8 percent of butanediol, 5 percent of ethanol, 0.6 percent of 1, 2-hexanediol, 0.6 percent of p-hydroxyacetophenone, 0.06 percent of PEG-60 hydrogenated castor oil, 0.005 percent of lactic acid, 0.1 percent of EDTA disodium, 0.01 percent of essence and the balance of deionized water.
Comparative application example 3
The composition prepared in comparative example 1 was applied to shampoo. The method comprises the following specific steps:
the shampoo comprises the following components in percentage by weight: 10% of cocamidopropyl betaine, 2% of decyl glucoside, 12% of sodium laureth sulfate, 10.6% of polyquaternium, 0.5% of PPG-3 octyl ether, 3% of cocamidomethyl MEA (methyl Ethyl Ether), 0.3% of sodium benzoate, 0.3% of phenoxyethanol, 0.2% of sodium citrate, 0.2% of citric acid, 0.1% of disodium EDTA (ethylene diamine tetraacetic acid), 0.5% of essence, 1% of the composition prepared in comparative example 1, and the balance of deionized water.
Comparative application example 4
The composition prepared in comparative example 2 was applied to shampoo. The method comprises the following specific steps:
the shampoo comprises the following components in percentage by weight: 10% of cocamidopropyl betaine, 2% of decyl glucoside, 12% of sodium laureth sulfate, 10.6% of polyquaternium, 0.5% of PPG-3 octyl ether, 3% of cocamidomethyl MEA (methyl Ethyl Ether), 0.3% of sodium benzoate, 0.3% of phenoxyethanol, 0.2% of sodium citrate, 0.2% of citric acid, 0.1% of disodium EDTA (ethylene diamine tetraacetic acid), 0.5% of essence, 1% of the composition prepared in comparative example 2, and the balance of deionized water.
Comparative application example 5
The composition prepared in comparative example 3 was applied to shampoo. The method comprises the following specific steps:
the shampoo comprises the following components in percentage by weight: 10% of cocamidopropyl betaine, 2% of decyl glucoside, 12% of sodium laureth sulfate, 10.6% of polyquaternium, 0.5% of PPG-3 octyl ether, 3% of cocamidomethyl MEA (methyl Ethyl Ether), 0.3% of sodium benzoate, 0.3% of phenoxyethanol, 0.2% of sodium citrate, 0.2% of citric acid, 0.1% of disodium EDTA (ethylene diamine tetraacetic acid), 0.5% of essence, 1% of the composition prepared in comparative example 3, and the balance of deionized water.
Comparative application example 6
The composition prepared in comparative example 4 was applied to shampoo. The method comprises the following specific steps:
the shampoo comprises the following components in percentage by weight: cocoamidopropyl betaine 10%, decyl glucoside 2%, sodium laureth sulfate 12%, polyquaternium-10.6%, PPG-3 octyl ether 0.5%, cocoamidomethyl MEA 3%, sodium benzoate 0.3%, phenoxyethanol 0.3%, sodium citrate 0.2%, citric acid 0.2%, disodium EDTA 0.1%, perfume 0.5%, composition 1% prepared in comparative example 4, and the balance deionized water.
Comparative application example 7
The composition prepared in comparative example 5 was applied to shampoo. The method comprises the following specific steps:
the shampoo comprises the following components in percentage by weight: cocoamidopropyl betaine 10%, decyl glucoside 2%, sodium laureth sulfate 12%, polyquaternium-10.6%, PPG-3 octyl ether 0.5%, cocoamidomethyl MEA 3%, sodium benzoate 0.3%, phenoxyethanol 0.3%, sodium citrate 0.2%, citric acid 0.2%, disodium EDTA 0.1%, perfume 0.5%, composition 1% prepared in comparative example 5, and the balance deionized water.
Comparative application example 8
The composition prepared in comparative example 6 was applied to shampoo. The method comprises the following specific steps:
the shampoo comprises the following components in percentage by weight: 10% of cocamidopropyl betaine, 2% of decyl glucoside, 12% of sodium laureth sulfate, 10.6% of polyquaternium, 0.5% of PPG-3 octyl ether, 3% of cocamidomethyl MEA (methyl MEA), 0.3% of sodium benzoate, 0.3% of phenoxyethanol, 0.2% of sodium citrate, 0.2% of citric acid, 0.1% of disodium EDTA (ethylene diamine tetraacetic acid), 0.5% of essence, 1% of the composition prepared in comparative example 6, and the balance of deionized water.
Shampoo consumer test evaluation
200 healthy volunteers, male and female, with the ages of 18-60 years old, who have head oil troubles, sensitive scalp and easy pruritus and meet related test requirements are recruited. Each group has 20 patients, and is administered for 4 weeks 3-5 times per week; then, the improvement rates of the experimental population for the head oil and the head itch are compared. The experimental counting adopts the principle of blind measurement and scoring, the full score is 5 points, and the score of more than or equal to 3 points represents that the effect is achieved, and the improvement can be realized; less than 3 points is considered to have no improving effect. The test results are shown in table 6.
TABLE 6
Consumer test results show that after the oil-control and itching-relieving composition is added into the shampoo in the application example 1 and the essence in the application example 2, the shampoo has an obvious positive effect on the improvement of the hair oil and the hair itch compared with a blank control group (a comparative application example 1 and a comparative application example 2). The analysis and comparison of the shampoo in the application example 1 and the comparative application examples 3, 4 and 5 show that the composition has better effect on the improvement of the hair oil and the head itch when the sodium polyglutamate, the arginine or the pea extract is added, which indicates that the three compositions have synergistic effect on the oil control and the itch relief. The oil-controlling and itching-relieving effects of comparative application example 6, comparative application example 7 and comparative application example 8 are also inferior to those of application example 1, and analysis shows that the skin permeability of the polyglutamic acid sodium, arginine or pea extract is weakened due to the lack of the penetration promoter and the emulsifier (polysorbate-20), so that the oil-controlling and itching-relieving effects are not obvious.
Claims (10)
1. A composition for controlling oil and relieving itching is characterized by comprising arginine, sodium polyglutamate, pea extract, a penetration enhancer and an emulsifier.
2. The composition according to claim 1, characterized by comprising the following components in parts by weight: 0.1-20 parts of arginine, 0.1-10 parts of sodium polyglutamate, 0.1-20 parts of pea extract, 0.1-15 parts of penetration enhancer and 0.1-15 parts of emulsifier.
3. The composition of claim 1 or 2, wherein the penetration enhancer is selected from at least one of vanillyl butyl ether, ethanol, ginger root extract, ginger root oil; the emulsifier is an amphiphilic emulsifier; preferably, the emulsifier comprises polysorbate-20.
4. The composition of claim 1 or 2, further comprising a polyol and water; the composition comprises the following components in parts by weight: 0.1-20 parts of arginine, 0.1-10 parts of sodium polyglutamate, 0.1-20 parts of pea extract, 0.1-10 parts of penetration enhancer, 0.1-15 parts of emulsifier, 1-30 parts of polyalcohol and 0.5-100 parts of water.
5. The composition of claim 4, wherein the polyol is at least one selected from the group consisting of glycerol, butylene glycol, 1, 3-propanediol, and propylene glycol.
6. The composition according to any one of claims 1,2, 5, wherein the composition is a nano-scale dispersion comprising a dispersed phase and a dispersion medium; the particle size of the dispersed phase is 100-800nm; the Zeta potential of the composition is from-60 to-20 mV.
7. A process for preparing a composition as claimed in any one of claims 4 and 5, comprising the steps of:
mixing water, arginine, sodium polyglutamate, semen Pisi Sativi extract and polyalcohol, and heating to obtain water phase; mixing penetration enhancer and emulsifier, and heating to obtain oil phase; and mixing the oil phase and the water phase, and homogenizing under high pressure to obtain the composition for controlling oil and relieving itching.
8. Use of a composition according to any one of claims 1 to 6 for the preparation of a cosmetic product.
9. A cosmetic comprising the composition according to any one of claims 1 to 6.
10. A shampoo comprising a composition as defined in any of claims 1 to 6.
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