CN114796059A - Moisturizing and repairing composition, skin care product and preparation method of skin care product - Google Patents
Moisturizing and repairing composition, skin care product and preparation method of skin care product Download PDFInfo
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Abstract
The invention provides a moisturizing and repairing composition which comprises the following components in parts by weight: sodium bis (lauramidoglutamine) lysine: 1-5 parts of kava root extract: 1-10 parts of fucus extract: 1-5 parts. The invention also provides a moisturizing and repairing skin care product which comprises the components. The invention also provides a preparation method of the moisturizing and repairing skin care product. The synergistic combination of the sodium bis (lauramide glutamine) lysine, the kava root extract and the fucus extract is adopted, the sodium bis (lauramide glutamine) lysine can penetrate through the horny layer and form a flaky crystal structure in intercellular lipid to achieve the effect of repairing and protecting, the skin tolerance is improved and the irritation is relieved by matching the effect of the kava root extract, and the high-efficiency moisturizing effect of the fucus extract is added, so that the moisture content of the horny layer skin is remarkably improved and the skin horny layer barrier is repaired, the dependence is not easy to generate after long-term use, and the cost is relatively low.
Description
Technical Field
The invention relates to a cosmetic and a preparation method thereof, in particular to a moisturizing and repairing composition, a skin care product and a preparation method of the skin care product.
Background
With the improvement of living standard of people, skin care is more and more valued, and moisture retention is the most important effect of cosmetics and is also the basis of skin care. Sufficient skin hydration is critical to healthy skin, and sufficient hydration facilitates enzymatic reactions and promotes stratum corneum maturation, maintaining stratum corneum elasticity.
In the contact between human body and the outside, the skin also plays a role of barrier, can prevent the damage of external chemical, physical, mechanical, biological and other factors to the skin, and can prevent the loss of moisture and nutrient substances. Factors that cause the skin barrier to be damaged are many, such as over-cleaning, use of harsh cosmetics, harsh environments, and the like. The impaired skin barrier is involved in the development of various skin problems, and thus, the efficacy of repairing the skin barrier is also an important direction for the development of skin care products.
The existing moisturizing repair skin care product mainly achieves the moisturizing repair function by adding ceramide, such as a composition and a cosmetic with the moisturizing repair effect disclosed in the Chinese patent application with the application publication number of CN 113616561A, a moisturizing repair cream disclosed in the Chinese patent application with the application publication number of CN 112870123A, a preparation method and application thereof, a moisturizing repair composition disclosed in the Chinese patent application with the application publication number of CN 112842985A, and the like. Ceramide is a substance which can be secreted and synthesized by a human body, but if the ceramide is supplemented by an external source for a long time, the ceramide has strong dependence, the capability of the cell for secreting the ceramide can not be fundamentally regulated, the self-synthesis and secretion capability can be weakened, once the ceramide is not supplemented, the more serious damage of the epidermal barrier can be caused, in addition, the raw material price of the ceramide is relatively high, and the cost of the moisturizing and repairing skin care product is relatively high.
In view of the above, the applicant has made intensive studies to solve the above problems and has made the present invention.
Disclosure of Invention
The invention aims to provide a moisturizing repair composition which is not easy to generate dependence after long-term use and has relatively low cost, a skin care product and a preparation method of the skin care product.
In order to achieve the purpose, the invention adopts the following technical scheme:
a moisturizing repair composition comprises the following components in parts by weight,
sodium bis (lauramidoglutamine) lysine: 1-5 parts of (A) a stabilizer,
kava root extract: 1-10 parts of (A) a solvent,
fucus vesiculosus extract: 1-5 parts.
A moisturizing and repairing skin care product comprises the following components in percentage by mass,
Pellicer L-30：0.3-1.7％，
DCR516：0.1-1％，
fucoidin-H: 2 to 10 percent of the total weight of the mixture,
auxiliary material matrix: 88 to 95 percent.
As a further development of the invention, the adjuvant matrix comprises water.
As a further improvement of the invention, the auxiliary material matrix further comprises one or more than two of a humectant, an emollient, an emulsifier, a thickener, a skin conditioner, a preservative, an aromatic and a pH regulator.
As a further improvement of the invention, the auxiliary material matrix comprises the following components in percentage by mass,
humectant: 2 to 20 percent of the total weight of the mixture,
and (3) an emollient: 0.3 to 25 percent of the total weight of the mixture,
emulsifier: 0.1 to 4 percent of the total weight of the mixture,
thickening agent: 0.1 to 2 percent of the total weight of the mixture,
skin conditioner: 0.1 to 10 percent of the total weight of the mixture,
preservative: 0 to 1 percent of the total weight of the mixture,
aromatic agent: 0 to 0.3 percent of the total weight of the mixture,
pH regulator: 0 to 1 percent of the total weight of the mixture,
water: the balance thereof.
As a further improvement of the invention, the humectant is glycerin and/or glyceryl polyether-26; the emollient is one or more of squalane, caprylic/capric triglyceride, dioctyl carbonate, hydrogenated polyisobutene and shea butter; the emulsifier is one or more than two of PEG-40 hydrogenated castor oil, hydrogenated lecithin and glycerol stearate citrate; the thickening agent is one or more than two of carbomer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, sodium polyacrylate and xanthan gum; the skin conditioning agent is niacinamide and/or tetrahydro-methyl pyrimidine carboxylic acid; the preservative is sodium benzoate and/or phenoxyethanol; the aromatic is essence; the pH regulator is aminomethyl propanol and/or citric acid.
A preparation method of a moisturizing and repairing skin care product comprises the following steps in sequence,
s1, respectively adding 50-84% by mass of water and 0.3-1.7% by mass of Pellicor L-30 into a water phase pot, stirring until the water and the Pellicor L-30 are completely and uniformly dispersed, then adding the solution in the water phase pot into a main pot, and heating to 70-80 ℃;
s2, respectively adding 0.3-25% by mass of an emollient and 0.1-4% by mass of an emulsifier into an oil phase pot, heating to 75 ℃, stirring until the mixture is uniformly mixed, and pumping the solution in the oil phase pot into the main pot under a homogenizing condition;
s3, cooling the temperature of the main pot to below 50 ℃, then respectively adding 0.1-1% of DCR516 and 2-10% of alginate jelly-H in mass percent into the main pot, and stirring until the materials are uniformly mixed to obtain the moisturizing and repairing skin care product.
As a further improvement of the invention, in step S1, 0.1-2% by mass of thickener and 2-20% by mass of humectant are added into the water phase pot at the same time.
As a further improvement of the invention, in step S2, 0.1-10% by mass of skin conditioning agent, 0-1% by mass of preservative, 0-0.3% by mass of fragrance and 0-1% by mass of pH regulator are added to the main pan at the same time.
By adopting the technical scheme, the invention has the following beneficial effects:
1. the synergistic combination of the sodium bis (lauryl glutamine) lysine, the kava root extract and the fucus extract is adopted, the sodium bis (lauryl glutamine) lysine can penetrate through the horny layer and form a flaky crystal structure in intercellular lipid to achieve the effect of repairing and protecting the skin, the skin tolerance is improved and the stimulation is relieved by matching the effect of the kava root extract, and the high-efficiency moisturizing effect of the fucus extract is multiplied, so that the moisture content of the horny layer skin is remarkably improved and the skin horny layer barrier is repaired, and because the ceramide is not required, the dependence is not easy to generate after long-term use, and the cost is relatively low.
2. Because the main component of Pellicor L-30 is sodium di (lauramide glutamine) lysine, DCR516 contains 90-100% of kava root extract, and the main component of fucoidan-H is Fucus vesiculosus extract, the skin care product of the invention also has the moisturizing and repairing effects of the composition, and the skin care product is not easy to generate dependence after long-term use and has relatively low cost.
3. The three key raw materials have the characteristics of convenient process, easily accepted cost and the like through synergistic effect, scientific proportion and reasonable dosage, and can achieve the efficacy of moisturizing and repairing.
Drawings
Fig. 1 is the experimental results based on zebrafish model in the example.
Detailed Description
The present invention will be further described with reference to specific examples, and the starting materials and test devices used in the following examples and comparative examples are commercially available, and the test steps or test devices not specified for specific conditions are performed according to conventional conditions or conditions recommended by the manufacturer of the test device, and will not be described in detail herein. Further, all percentages are mass percentages unless otherwise indicated.
The invention provides a moisturizing and repairing composition which comprises the following components in parts by weight:
sodium bis (lauramidoglutamine) lysine: 1-5 parts of (A) a stabilizer,
kava root extract: 1-10 parts of (by weight),
fucus vesiculosus extract: 1-5 parts.
The composition is prepared by compounding specific raw materials, wherein the fucus extract helps the horny layer to absorb water and form a hidden moisturizing membrane on the surface of the skin, sodium di (lauramide glutamine) lysine can penetrate the horny layer and form a flaky crystal structure in intercellular lipid so as to achieve the effect of repairing and protecting the skin, and the kava root extract can remarkably improve the tolerance of the skin and relieve the stimulation, and can be widely applied to various skin care products.
The invention also provides a moisturizing and repairing skin care product containing the composition, which comprises the following components in percentage by mass:
Pellicer L-30：0.3-1.7％，
DCR516：0.1-1％，
fucoidin-H: 2 to 10 percent of the total weight of the mixture,
auxiliary material matrix: 88 to 95 percent.
Of the above components, Pellicor L-30, DCR516 and furcellaran-H are trade names of raw materials and are directly available from the market, wherein the main component of Pellicor L-30 is sodium bis (lauramide glutamine) lysine, specifically consisting of 29% of sodium bis (lauramide glutamine) lysine and 71% of water; DCR516 contains 90-100% kava root extract, wherein the active ingredient name is 2000-3000ppm kavain (cas: 3155-48-4); the main ingredient of Fucus vesiculosus-H is Fucus vesiculosus extract, specifically composed of 83.5% of water, 10% of glycerol, 5% of Fucus vesiculosus extract, 0.5% of butanediol, 0.5% of 1, 2-hexanediol and 0.5% of p-hydroxyacetophenone.
In the above components, the adjuvant matrix includes water, which may be deionized water or other water meeting the requirements of daily chemical production enterprises, and is not described in detail here. The auxiliary material matrix further comprises one or more than two of a humectant, an emollient, an emulsifier, a thickener, a skin conditioner, a preservative, an aromatic and a pH regulator, and can be selected according to actual needs, in the embodiment, the auxiliary material matrix comprises the humectant, the emollient, the emulsifier, the thickener, the skin conditioner, the preservative, the aromatic and the pH regulator, and the content of each component of the auxiliary material matrix is as follows according to the mass percentage:
humectant: 2 to 20 percent of the total weight of the mixture,
and (3) an emollient: 0.3-25% of the total weight of the mixture,
emulsifier: 0.1 to 4 percent of the total weight of the mixture,
thickening agent: 0.1 to 2 percent of the total weight of the mixture,
skin conditioner: 0.1 to 10 percent of the total weight of the mixture,
preservative: 0 to 1 percent of the total weight of the mixture,
aromatic agent: 0 to 0.3 percent of the total weight of the mixture,
pH regulator: 0 to 1 percent of the total weight of the mixture,
water: the balance being.
Preferably, in the present embodiment, the humectant is glycerin and/or glycerin polyether-26; the emollient is one or more of squalane, caprylic/capric triglyceride, dioctyl carbonate, hydrogenated polyisobutene, and shea butter; the emulsifier is one or more of PEG-40 hydrogenated castor oil, hydrogenated lecithin, and glyceryl stearate citrate; the thickener is one or more of carbomer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, sodium polyacrylate and xanthan gum; the skin conditioning agent is niacinamide and/or tetrahydro-methyl pyrimidine carboxylic acid; the preservative is sodium benzoate and/or phenoxyethanol; the aromatic is essence with fragrance selected from one or more of flower fragrance, fruit fragrance, and radix aucklandiae; the pH regulator is aminomethyl propanol and/or citric acid.
The invention also provides a preparation method of the moisturizing and repairing skin care product, which comprises the following steps of:
s1, respectively adding 50-84% by mass of water, 0.1-2% by mass of thickening agent, 2-20% by mass of humectant and 0.3-1.7% by mass of Pellicor L-30 into an aqueous phase pot, stirring the mixture until the mixture is completely and uniformly dispersed, then adding the solution in the aqueous phase pot into a main pot, and heating the mixture to 70-80 ℃.
S2, adding 0.1-10% by mass of a skin conditioner, 0-1% by mass of a preservative, 0-0.3% by mass of an aromatic, 0-1% by mass of a pH regulator, 0.3-25% by mass of an emollient and 0.1-4% by mass of an emulsifier into an oil phase pot, respectively, heating to 75 ℃ (a certain temperature error is allowed, for example, an error of 5 ℃), stirring uniformly, pumping the solution in the oil phase pot into a main pot under a homogenizing condition (the rotation speed of stirring is 1500-: minus 0.05MPa to minus 0.09 MPa.
S3, cooling the temperature of the main pot to below 50 ℃ by using circulating cooling water, then respectively adding 0.1-1% by mass of DCR516 and 2-10% by mass of alginate jelly-H into the main pot, and stirring until the materials are uniformly mixed to obtain the moisturizing repair skin care product, wherein the moisturizing repair skin care product can be moisturizing repair essence water, moisturizing repair body cream, moisturizing repair essence liquid, moisturizing repair eye cream, moisturizing repair essence cream, moisturizing repair mask and other product types.
Various examples were prepared according to the above preparation method using different formulations as follows:
example 1, moisturizing and repair essence.
The skin care product of example 1, which is a moisturizing repair essence, was prepared according to the formulation shown in table 1 below, and five moisturizing essences as comparative examples (comparative examples), which are comparative examples 1 to 5, were prepared according to the formulation shown in table 1 below. In the preparation of comparative examples, if the components to be added in the preparation method are not in the formulation listed in table 1 below, the corresponding components are not added in the preparation.
Table 1: formulation composition (%)
The six moisturizing essences are detected, and specific detection items, methods and results are as follows:
(1) the stability test, which is to place the moisturizing repair essence prepared in comparative examples 1-5 and example 1 at room temperature, 45 ℃ and-10 ℃ respectively, examine the time of 7 days, and observe whether the sample is delaminated, if the sample is not changed before and after the specified time, the sample is marked as "ok", and if the delamination phenomenon occurs, the sample is marked as "unstable", and the results are shown in the following table 2.
Table 2: stability investigation of moisturizing and repairing essence
| Sample source | At room temperature | 45℃ | -10℃ |
| Comparative example 1 | ok | ok | ok |
| Comparative example 2 | ok | ok | ok |
| Comparative example 3 | ok | ok | ok |
| Comparative example 4 | ok | ok | ok |
| Comparative example 5 | ok | ok | ok |
| Example 1 | ok | ok | ok |
From the above table 2, it can be found that no delamination occurs when each moisturizing and repairing essence sample is placed at room temperature, 45 ℃ and-10 ℃ for 7 days, which indicates that the formula of the system is structurally stable.
(2) The method is characterized in that the continuous water replenishing effect of the horny layer of the forearm is detected, comparative examples 1-5 and example 1 are respectively used for consumers (human bodies), a moisture content tester (the moisture content test model adopted in the embodiment is Corneometer CM825) is adopted to detect the continuous water replenishing effect of the horny layer on the inner side of the forearm of a testee before, after 1h, 2h, 4h and 8h (wherein h is time unit hour) of a moisture-preserving repair essence sample is used, specifically, the sample is coated on the surface of the skin to continuously replenish the moisture of the horny layer of the forearm, the effect can be slowly weakened along with the change of time, the moisture of the horny layer of the skin in a specified time is tracked and measured, and the effect of replenishing the moisture of the horny layer of the sample to the horny layer can be evaluated. The stratum corneum moisture assay is based on the electric capacity principle, and the numerical value is bigger, and the stratum corneum moisture content is higher. The results are shown in table 3 below, where the blank is a consumer (human) who did not use any moisturizing repair serum sample.
Table 3: skin moisture test at various time points (A.U.)
| Sample source | T 0 | T(1h) | T(2h) | T(4h) | T(8h) |
| Blank control | 32.1 | 32.3 | 33.6 | 33.4 | 31.5 |
| Comparative example 1 | 32.2 | 35.1 | 34.9 | 33.8 | 32.5 |
| Comparative example 2 | 32.1 | 39.2 | 38.8 | 37.6 | 37.1 |
| Comparative example 3 | 32.5 | 42.1 | 41.1 | 39.5 | 37.8 |
| Comparative example 4 | 32.3 | 44.8 | 43.2 | 41.8 | 38.1 |
| Comparative example 5 | 32.6 | 43.2 | 42.5 | 40.6 | 38.0 |
| Example 1 | 32.8 | 47.8 | 47.0 | 43.0 | 39.8 |
From the results of the blank control and comparative example 1, it can be seen that the moisturizing repair composition is not added to the formulation, and only 1% of glyceryl polyether-26 is used as the moisturizing agent, and the product has no moisturizing effect. From the results of comparative example 2, it is understood that when the amount of glyceryl polyether-26 is increased to 5%, the product has a certain moisturizing effect, but the effect is not strong. From the results of comparative example 3, it can be seen that when the glyceryl polyether-26 is selected as the moisturizing agent, and 5% of the fucoidin-H is matched as the moisturizing repair component, the moisturizing effect is obviously improved, which indicates that the fucus extract plays a determining role in moisturizing effect. The results of comparative example 4 show that the addition of Pellicor L-30 as a moisturizing repair composition has a certain reinforcing effect on the moisturizing effect, and the effect of 1+1>2 is verified. As can be seen from the results of comparative example 5, the addition of DCR516 had substantially no effect on moisturizing efficacy. The results of example 1 show that the simultaneous addition of Pellicer L-30 and DCR516 has a significant synergistic effect on the moisturizing effect, which indicates that the soothing skin of kava root extract and the amphiphilic structure of sodium di (lauramide glutamine) lysine play an important role in further playing the moisturizing effect.
(3) The effect of continuously replenishing water to the stratum corneum of facial skin was examined, and the effect of the moisturizing repair essence on the stratum corneum of facial skin was determined by measuring the transepidermal water loss rate of skin using each of comparative examples 3, 5 and 1 to a consumer (human body). Specifically, the open transepidermal water loss index (Tewameter TM HEX) of the facial skin of the subject was measured before use, 14 days after use, and 28 days after use, and the open transepidermal water loss meter evaluated the skin barrier function based on Fick's diffusion law, the larger the value, the more severely the skin barrier function was impaired. The results are shown in Table 4 below.
Table 4: water loss rate of skin per epidermis (g/cm 2. h) at different time points
| Sample source | D 0 | D 14 | D 28 |
| Comparative example 3 | 23.88 | 21.85 | 20.08 |
| Comparative example 4 | 23.78 | 20.51 | 19.85 |
| Example 1 | 23.83 | 19.95 | 18.41 |
From the results of comparative example 3, it is understood that only 5% of fucoidan-H was added to the formulation, and the moisturizing effect was exhibited, but the repairing effect was relatively limited. The results of comparative example 4 show that the Pellicor L-30 is added on the basis of the formula of comparative example 3, and the repairing effect is obviously improved, which indicates that the sodium di (lauramide glutamine) lysine can penetrate through the stratum corneum and form a lamellar crystal structure in intercellular lipid to play a crucial role in the repairing effect. The results of example 1 show that the simultaneous addition of Pellicer L-30 and DCR516 has a significant synergistic effect on the repair effect, because the amphiphilic molecular structure of sodium di (laurylaminoglutamine) lysine promotes the barrier function of skin and the health of skin remodeling, the transdermal water loss rate is effectively reduced, and the fucus extract is matched to help the horny layer absorb water and form a hidden moisturizing membrane and a kava root extract on the skin surface, so that the skin tolerance and irritation relieving effects can be significantly improved. The three key raw materials have sufficient moisturizing and repairing effects on the skin through synergistic effect and scientific proportion.
Example 2, preparation of moisturizing and repairing essence lotion.
According to the preparation method, 87.9% of water, 0.5% of Pellicor L-30, 0.15% of xanthan gum and 5% of glycerol are added into a water phase pot, stirred until the mixture is completely and uniformly dispersed, then added into a main pot, heated to 70-80 ℃, added into an oil phase pot with 0.3% of squalane and 0.15% of PEG-40 hydrogenated castor oil, heated and stirred to be uniformly mixed, and pumped into the main pot under the condition of homogenization; then cooling the main pot to below 50 ℃, adding 2% of nicotinamide, 0.3% of tetrahydro-methyl pyrimidine carboxylic acid, 0.3% of DCR516, 3% of alginate-H and 0.4% of phenoxyethanol, stirring until the materials are uniformly mixed, and preparing the moisturizing and repairing essence water.
Example 3, preparation of moisturizing and repairing essence lotion.
According to the preparation method, 86.45% of water, 0.6% of Pellicor L-30, 0.2% of sodium polyacrylate and 5% of glyceryl polyether-26 are added into a water phase pot, stirred until the mixture is completely and uniformly dispersed, then added into a main pot, and heated to 70-80 ℃. Adding 0.5% caprylic/capric triglyceride and 0.15% sodium methylstearyltaurate into oil phase pan, heating and stirring to mix well, and pumping into main pan under homogenizing condition; then cooling the main pot to below 50 ℃, adding 3% of nicotinamide, 0.5% of tetrahydro-methyl pyrimidine carboxylic acid, 0.2% of DCR516, 3% of alginate-H and 0.4% of sodium benzoate, stirring until the materials are uniformly mixed, and preparing the moisturizing and repairing essence.
Example 4, preparation of moisturizing and repairing essence milk.
According to the preparation method, 72.77% of water, 1% of Pellicor L-30, 0.3% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and 6% of glyceryl polyether-26 are added into a water phase pot, stirred until the mixture is completely and uniformly dispersed, then added into a main pot, and heated to 70-80 ℃. Adding 2% of squalane, 3% of hydrogenated polyisobutene, 3% of shea butter and 2% of glycerol stearate citrate into an oil phase pot, heating and stirring to uniformly mix the mixture, and pumping the mixture into a main pot under a homogeneous condition; then cooling the main pot to below 50 ℃, adding 0.1% of dipotassium glycyrrhizinate, 3% of nicotinamide, 0.4% of tetrahydromethyl pyrimidine carboxylic acid, 0.8% of DCR516, 5% of alginate-H, 0.4% of phenoxyethanol, 0.08% of essence and 0.15% of aminomethyl propanol, stirring until the materials are uniformly mixed, and preparing the moisturizing and repairing essence milk.
Example 5, preparation of moisturizing mask.
According to the preparation method, 88.67% of water, 0.3% of Pellicor L-30, 0.2% of carbomer, 0.3% of sodium polyacrylate and 5% of glycerol are added into a water phase pot, stirred until the carbomer and the sodium polyacrylate are completely and uniformly dispersed, then added into a main pot, and heated to 70-80 ℃. Adding 0.5% dioctyl carbonate and 0.15% PEG-40 hydrogenated castor oil into an oil phase pot, heating and stirring until the mixture is uniformly mixed, and pumping into a main pot under the condition of homogenization; then cooling the main pot to below 50 ℃, adding 2% of nicotinamide, 0.15% of tetrahydro-methyl pyrimidine carboxylic acid, 0.2% of DCR516, 2% of alginate-H, 0.4% of phenoxyethanol, 0.08% of essence and 0.05% of sodium citrate, stirring until the materials are uniformly mixed, and finishing the preparation of the moisturizing and repairing mask
Example 6, preparation of moisturizing mask.
According to the preparation method, 67.52 percent of water, 0.5 percent of Pellier L-30, 0.4 percent of xanthan gum and 0.4 percent of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and 8 percent of glycerol polyether-26 are added into a water phase pot, stirred until the components are completely and uniformly dispersed, then added into a main pot, and heated to 70-80 ℃. Adding 3% of squalane, 3% of hydrogenated polyisobutene, 4% of shea butter, 3% of glyceryl stearate citrate and 0.6% of PEG-40 hydrogenated castor oil into an oil phase pot, heating and stirring to uniformly mix the mixture, and pumping the mixture into a main pot under a homogenizing condition; then cooling the main pot to below 50 ℃, adding 4% of nicotinamide, 0.4% of tetrahydro-methyl pyrimidine carboxylic acid, 0.5% of DCR516, 4% of alginate-H, 0.4% of phenoxyethanol, 0.08% of essence and 0.2% of aminomethyl propanol, stirring until the materials are uniformly mixed, and preparing the moisturizing and repairing facial cream.
The moisturizing and repairing effects of the skin care products prepared in examples 2 to 6 were evaluated based on a zebra fish model. Excessive activation and infiltration of neutrophils and macrophages are the pathological basis of chronic inflammation and other inflammation related diseases, so that the neutrophils and macrophages at an inflammation part can be effectively relieved, the promotion effect of moisturizing repair products on the clearance of the neutrophils and macrophages at the inflammation part can be researched by utilizing zebra fish to manufacture a tailcut inflammation model, and the specific experimental process comprises the following steps: the inflammatory model is manufactured by cutting the tail fin of the zebra fish, the zebra fish with the cell aggregation number of about 30 is selected after 6 hours, the zebra fish is treated for 6 hours by the skin care product prepared in the embodiment 2-6, the experimental result is shown in figure 1, and the result shows that the skin care product prepared in the embodiment 2-6 can promote the reverse migration of neutrophils and macrophages at the wound of the zebra fish or induce the apoptosis of the neutrophils and the macrophages, and can play the anti-inflammatory repair role.
Example 7, preparation of moisturizing and repairing face essence.
According to the preparation method, 86.95% of water, 0.3% of Pellicor L-30, 0.2% of sodium polyacrylate and 5% of glyceryl polyether-26 are added into a water phase pot, stirred until the mixture is completely and uniformly dispersed, then added into a main pot, and heated to 70-80 ℃. Adding 0.5% caprylic/capric triglyceride and 0.15% sodium methylstearyltaurate into oil phase pan, heating and stirring to mix well, and pumping into main pan under homogenizing condition; cooling the main pan to below 50 deg.C, adding 3% nicotinamide, 0.5% tetrahydro-methyl pyrimidine carboxylic acid, 1% DCR516, 2% alginate-H, and 0.4% sodium benzoate, stirring to mix, and making into moisture-keeping repair essence
Example 8, preparation of moisturizing and repairing face essence.
According to the preparation method, 86.95% of water, 0.3% of Pellicor L-30, 0.2% of sodium polyacrylate and 5% of glyceryl polyether-26 are added into a water phase pot, stirred until the mixture is completely and uniformly dispersed, then added into a main pot, and heated to 70-80 ℃. Adding 0.5% caprylic/capric triglyceride and 0.15% sodium methylstearyltaurate into oil phase pan, heating and stirring to mix well, and pumping into main pan under homogenizing condition; cooling the main pan to below 50 deg.C, adding 3% nicotinamide, 0.5% tetrahydro-methyl pyrimidine carboxylic acid, 1% DCR516, 2% alginate-H, and 0.4% sodium benzoate, stirring to mix, and making into moisture-keeping repair essence
Example 9 preparation of moisturizing and skin-care essence cream.
According to the preparation method, 51.77% of water, 1% of Pellicor L-30, 0.3% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and 25% of glyceryl polyether-26 are added into a water phase pot, stirred until the mixture is completely and uniformly dispersed, then added into a main pot, and heated to 70-80 ℃. Adding 2% of squalane, 3% of hydrogenated polyisobutene, 3% of shea butter and 4% of glycerol stearate citrate into an oil phase pot, heating and stirring to uniformly mix the mixture, and pumping the mixture into a main pot under a homogeneous condition; cooling the main pot to below 50 ℃, adding 0.1% dipotassium glycyrrhizinate, 3% nicotinamide, 0.4% tetrahydromethyl pyrimidine carboxylic acid, 0.8% DCR516, 5% alginate gel-H, 0.4% phenoxyethanol, 0.08% essence and 0.15% aminomethyl propanol, stirring until the materials are uniformly mixed, and preparing the moisturizing and repairing essence milk
Example 10, preparation of moisturizing and skin-care essence cream.
According to the preparation method, 70.27% of water, 1% of Pellicor L-30, 0.3% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and 2% of glyceryl polyether-26 are added into a water phase pot, stirred until the mixture is completely and uniformly dispersed, then added into a main pot, and heated to 70-80 ℃. Adding 2% of squalane, 3% of hydrogenated polyisobutene, 3% of shea butter and 2% of glycerol stearate citrate into an oil phase pot, heating and stirring to uniformly mix the mixture, and pumping the mixture into a main pot under a homogeneous condition; cooling the main pot to below 50 ℃, adding 0.1% dipotassium glycyrrhizinate, 9.5% nicotinamide, 0.4% tetrahydromethyl pyrimidine carboxylic acid, 0.8% DCR516, 5% alginate-H, 0.4% phenoxyethanol, 0.08% essence and 0.15% aminomethyl propanol, stirring until the materials are uniformly mixed, and preparing the moisturizing and repairing essence milk
The present invention has been described in detail with reference to the specific embodiments, but the embodiments of the present invention are not limited to the above embodiments, and those skilled in the art can make various modifications to the present invention based on the prior art, which fall within the scope of the present invention.
Claims (9)
1. The moisturizing repair composition is characterized by comprising the following components in parts by weight,
sodium bis (lauramidoglutamine) lysine: 1-5 parts of (A) a stabilizer,
kava root extract: 1-10 parts of (A) a solvent,
fucus vesiculosus extract: 1-5 parts.
2. A moisturizing and repairing skin care product is characterized by comprising the following components in percentage by mass,
Pellicer L-30：0.3-1.7％，
DCR516：0.1-1％，
fucoidin-H: 2 to 10 percent of the total weight of the mixture,
auxiliary material matrix: 88 to 95 percent.
3. The moisturizing repair skin care product of claim 2 wherein the adjuvant matrix comprises water.
4. The moisturizing repair skin care product of claim 3 wherein the adjunct matrix further comprises one or more of a humectant, an emollient, an emulsifier, a thickener, a skin conditioner, a preservative, a fragrance, and a pH adjuster.
5. The moisturizing repair skin care product according to claim 2, wherein the auxiliary material matrix comprises the following components in percentage by mass,
humectant: 2 to 20 percent of the total weight of the mixture,
and (3) an emollient: 0.3 to 25 percent of the total weight of the mixture,
emulsifier: 0.1 to 4 percent of the total weight of the mixture,
thickening agent: 0.1 to 2 percent of the total weight of the mixture,
skin conditioner: 0.1 to 10 percent of the total weight of the mixture,
preservative: 0 to 1 percent of the total weight of the mixture,
aromatic agent: 0 to 0.3 percent of the total weight of the mixture,
pH regulator: 0 to 1 percent of the total weight of the mixture,
water: the balance being.
6. The moisturizing repair skin care product of claim 4 or 5 wherein the moisturizing agent is glycerin and/or glyceryl polyether-26; the emollient is one or more of squalane, caprylic/capric triglyceride, dioctyl carbonate, hydrogenated polyisobutene and shea butter; the emulsifier is one or more than two of PEG-40 hydrogenated castor oil, hydrogenated lecithin and glycerol stearate citrate; the thickening agent is one or more than two of carbomer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, sodium polyacrylate and xanthan gum; the skin conditioning agent is niacinamide and/or tetrahydro-methyl pyrimidine carboxylic acid; the preservative is sodium benzoate and/or phenoxyethanol; the aromatic is essence; the pH regulator is aminomethyl propanol and/or citric acid.
7. A preparation method of a moisturizing and repairing skin care product is characterized by comprising the following steps of sequentially carrying out,
s1, respectively adding 50-84% by mass of water and 0.3-1.7% by mass of Pellicor L-30 into a water phase pot, stirring until the water and the Pellicor L-30 are completely and uniformly dispersed, then adding the solution in the water phase pot into a main pot, and heating to 70-80 ℃;
s2, respectively adding 0.3-25% by mass of an emollient and 0.1-4% by mass of an emulsifier into an oil phase pot, heating to 75 ℃, stirring until the mixture is uniformly mixed, and pumping the solution in the oil phase pot into the main pot under a homogenizing condition;
s3, cooling the temperature of the main pot to below 50 ℃, then respectively adding 0.1-1% of DCR516 and 2-10% of alginate jelly-H in mass percent into the main pot, and stirring until the materials are uniformly mixed to obtain the moisturizing and repairing skin care product.
8. The method of preparing a moisturizing repair skin care product according to claim 7, wherein in step S1, 0.1-2% by mass of the thickener and 2-20% by mass of the humectant are added to the water phase pan at the same time.
9. The method of preparing a moisturizing repair skin care product according to claim 7, wherein in step S2, 0.1-10% by mass of a skin conditioner, 0-1% by mass of a preservative, 0-0.3% by mass of a fragrance, and 0-1% by mass of a pH adjuster are added to the main pan at the same time.
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