CN109157453A - A kind of pro-skin slow releasing composition and its cosmetics - Google Patents
A kind of pro-skin slow releasing composition and its cosmetics Download PDFInfo
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- CN109157453A CN109157453A CN201811232591.XA CN201811232591A CN109157453A CN 109157453 A CN109157453 A CN 109157453A CN 201811232591 A CN201811232591 A CN 201811232591A CN 109157453 A CN109157453 A CN 109157453A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention discloses a kind of pro-skin slow releasing composition and its cosmetics, it is desirable to provide a kind of quick, potent reparation sebum film of energy restores simultaneously robust skin barrier system function, the composition for having effects that good moisturizing and repairing；Technical points are, the composition mainly include two (lauramide glutamine) Sodium lysinates of 0.1-2 parts by weight, the lycium barbarum berry extract of 4-10 parts by weight, the Echinacea angustifolia extract of 2-5 parts by weight, the palpus extractive of usnea of 5-10 parts by weight, 0.1-1 parts by weight tetrahydro methylpyrimidine carboxylic acid；Belong to cosmetic technical field.
Description
Technical field
The invention discloses a kind of compositions, specifically, being a kind of pro-skin slow releasing composition, the invention also discloses contain
The cosmetics of the pro-skin slow releasing composition, belong to cosmetic technical field.
Background technique
Key whether skin is delicate, plentiful, beautiful is the water content in skin, is to maintain skin using moisturizing cosmetic
The important channel of skin moisture.So-called moisturizing cosmetic is exactly to contain moisturizing ingredient inside cosmetics, is able to maintain keratoderma one
Fixed water content can increase moisture of skin, humidity, to restore the gloss and elasticity of skin.Its feature is not only to be able to maintain skin
The balance of skin moisture, and important oil components, hydrophily moisturizing ingredient and moisture can also be supplemented, and as active constituent
It with the carrier of medicament, is allowed to easily be absorbed by skin, reaches conditioning and skin nutrition, repairs epidermal barrier function, increase epidermis
Water content, exactly be increase horn cell water content purpose, make skin moisturizing, health.
Skin barrier function obstacle is a huge hidden danger of skin health, is that sensitive, skin aging, skin are dry
One of dry equal main inducing of dermatopathies such as skins sub-health state and anaphylaxis.Skin barrier function and skin in recent years
The discovery of allergy correlation current research: skin barrier function obstacle is not only conducive to anaphylactogen and enters skin induction allergy, simultaneously
So that skin keratin is formed cell and generate the rush allergenic factor such as TSLP, chemotactic factor for eosinophils, starting skin allergy inflammation is anti-
It answers；And the inflammatory factors such as histamine, serotonin of allergic inflammation reaction release cause itch scratching to cause skin barrier physical
Damage, while keratinocyte also being inhibited to generate natural moisturizing factor and activated protein exacerbation skin barrier function obstacle；Shape
It is to lead to the skin barriers such as atopic dermatitis, cutaneous pruritus at " the inflammation vicious circle of skin barrier function obstacle-itch-"
The major reason of the recurrent exerbation of dysfunction illness.
The main method for the treatment of skin barrier obstacle is moisturizer treatment at present, and skin moisturizer mainly has grease envelope at present
Moisturizer, hydrophilic matrix moisture-absorption humectant, hydration moisturizer etc. are closed, but simple moisturizer treatment only treats the symptoms, and uses physics
Principle or aquation carry out the moisturizing on basis, and the validity and duration of moisturizing are barely satisfactory, cannot carry out deep layer to skin
Moisturizing is to fundamentally solve the problems, such as skin barrier function obstruction recovery.
It is mostly common essence, lotion or cream that cosmetics are repaired in domestic and international common moisturizing at present, due to skin barrier
The presence of effect is the obstruction of cuticula again, the active constituent of most of external cosmetics especially non-fat-soluble active constituent,
It is difficult to cause its assimilation effect poor through skin barrier, and is easily actually reached skin because the factors such as washing lead to ingredients from lossing
The active constituent of skin is less, causes the waste of active constituent, and biggish dosage is needed to can be only achieved desired effect.Therefore, it is necessary to
Seek can to promote active constituent to enter skin barrier, and can method of the slow release to achieve the desired results in vivo.Currently,
Relatively conventional is to prepare Liposome Cosmeatics, such as Chinese patent literature using carrier of the liposome as active constituent
CN105581912A discloses a kind of slow release liposome shin moisturizer and preparation method thereof with crease-resistant effect.But the system of liposome
It is standby urgently to overcome there are still many technological difficulties, such as improve the encapsulation rate and scalp absorbent slow release effect of active constituent.
Summary of the invention
In order to solve the disadvantage that the prior art and shortcoming, the first purpose of the invention is to provide a kind of pro-skin sustained releases
Composition, the composition can make active constituent continuously be percutaneous absorption, improve the bioavailability of active constituent,
To promote the moisturizing moisture holding capacity of skin, quick, potent reparation sebum film repairs simultaneously robust skin barrier system function, tool
There is good moisturizing and repairs effect.
A second object of the present invention is to provide the skin care item of the slow releasing composition containing pro-skin.
For this purpose, technical solution provided by the invention is such that
A kind of pro-skin slow releasing composition, main two (lauramide glutamine) Sodium lysinates including 0.1-2 parts by weight,
The palpus sunglo extraction of the lycium barbarum berry extract of 4-10 parts by weight, the Echinacea angustifolia extract of 2-5 parts by weight, 5-10 parts by weight
The tetrahydro methylpyrimidine carboxylic acid of object, 0.1-1 parts by weight.
Further, above-mentioned a kind of pro-skin slow releasing composition further includes that the Quercus suber barks of 0.5-5 parts by weight mentions
Take object.
Further, above-mentioned a kind of pro-skin slow releasing composition further includes the Acer palmatum leaf extract of 0.5-3 parts by weight.
Another technical solution of the invention is to provide the cosmetics of the slow releasing composition containing pro-skin.
The toiletry bag is containing the pro-skin slow releasing composition and the acceptable auxiliary agent of cosmetics；With the weight of the cosmetics
For 100% meter, the pro-skin slow releasing composition accounts for the 0.5-5% of cosmetics total weight.
Further, the auxiliary agent mainly contains surfactant, polyalcohol, grease；With the weight of the cosmetics for 100%
Meter, the surfactant account for the 0.15-2% of cosmetics total weight, and polyalcohol accounts for 5-10%, and grease accounts for 3-8%.
Further, the surfactant is PEG-20 methyl sesquistearate, sodium bacillus subtilis lipopeptide, chrysanthemum
Powder lauryl carbamate, -2 stearate of polyglycereol, stearine, stearyl alcohol, arachidic alcohol, docosyl alcohol, arachidic alcohol
One or more of glucoside.The polyalcohol is one or more of 1,3- propylene glycol, erythrite, glycerol.The oil
Rouge is lauric alcohol-caprylate/decylate, C13-16 isoparaffin, saualane, jojoba seed oil, Seabuckthorm Seed Oil, egg oil, Australia
One or more of continent nut seed oil.
The acceptable auxiliary agent of cosmetics also wraps other than above surfactant, polyalcohol, grease essential component
Include water, moisturizer, thickener, pH adjusting agent, antioxidant, skin conditioning agent etc..
In some specific embodiments of the invention, the cosmetics are essence or lotion or cream.
Compared with prior art, technology technical solution provided by the invention has following technological merit:
1, two (lauramide glutamine) Sodium lysinates in technical solution provided by the invention are that one kind contains peptidyl
Twin-lock is hydrophilic/double-locking amphiphilic matchmaker's property compound of rouge molecule, chemical structure is similar with ceramide structure, double bond and amide
Bond is closed, and containing multiple hydrophily tails, therefore has good skin-care effect；Simultaneously because it has plural hydrophobic group and plural number parent
Water base integrated structure can form twin-lock structure, have preferable emulsification, solubilising and peptizaiton, be that composition twin-lock amino acid is micro-
The main component of emulsifying technology.The multi-layer vesicles structure more than 10 layers can be obtained using it, this microstructure can be fine
Package cosmetics in active material, then active material is sustained, allow cosmetics the effect of ingredient in a steady stream
Skin constantly is acted on, since the vesica partial size that it is formed is smaller, cuticula can be infiltrated into, impaired skin is repaired,
To reach good skin effect；Lycium barbarum berry extract and Echinacea angustifolia extract can stimulate aquaporin AQP3's
Expression, it is ensured that active constituent is continuously percutaneous absorption, improves the bioavailability of active constituent, it is ensured that product efficacy
It maximizes；Tetrahydro methylpyrimidine carboxylic acid is the important substance for maintaining osmotic balance, unique molecular structure, with very strong
Hydrone complexing power, intracellular free water structuring can be made, improve skin moisture-keeping moisture holding capacity persistently, deactivate after skin
Skin moisture holding capacity will not decline at once, be very outstanding moisturizer, moreover it is possible to alleviate various pressure suffered by skin, it is such as ultraviolet
Degradation of skin caused by skin aging, surfactant caused by line loss wound, dry environment etc. effectively promotes the immune of Skin Cell
Protective capacities increases cell repair ability, allows the skin to the invasion for effectively antagonizing microorganism and anaphylactogen.
Pro-skin slow releasing composition provided by the invention mentions lycium barbarum berry extract, Echinacea angustifolia extract, palpus sunglo
Take object, several ingredients of tetrahydro methylpyrimidine carboxylic acid to combine, at the same using two (lauramide glutamine) Sodium lysinates by its
It wraps up, forms multi-layer vesicles structure, active constituent is constantly delivered to the cuticula of skin, stimulate aquaporin
The expression of AQP3, it is ensured that active constituent is continuously percutaneous absorption, improves the bioavailability of active constituent, to be promoted
The moisturizing moisture holding capacity of skin, quick, potent reparation sebum film, restores and robust skin barrier system function, increase cell are repaired
Reactivation power.The above ingredient is further compounded with Quercus suber bark extract, Acer palmatum leaf extract, can obtain preferably guarantor
Wet and repairing effect.
2, cosmetics provided by the invention, surfactant therein are the emulsifier of natural botanical source, and grease is day
The vegetable fat in right source, in the selection of raw material, choose with the homologous formula components of skin, and using D phase emulsifying technology, double
It locks amino acid micro-emulsion technology or liquid crystal emulsified technology constructs emulsification system, the product emulsification partial size of formation is small, improves production
The skin-friendly of product facilitates active constituent and is preferably absorbed by skin；Addition has the composition of pro-skin sustained release simultaneously, can be more preferable
The cuticula that active constituent is delivered to skin, stimulate aquaporin AQP3 expression, it is ensured that active constituent is continually
Ground is percutaneous absorption, improves the bioavailability of active constituent, to promote the moisturizing moisture holding capacity of skin, increases cell repair
Ability has good moisturizing and repairing effect.
Specific embodiment
Below with reference to embodiment, claim of the invention is described in further detail, but is not constituted pair
Any restrictions of the invention, the modification of anyone limited times made in the claims in the present invention protection scope, still in this hair
Within bright claims.
It should be noted that raw material employed in skill scheme provided by the invention passes through routine unless otherwise specified
Means preparation is bought by commercial channel.Wherein, lycium barbarum berry extract and Echinacea angustifolia extract are purchased from vast gloomy stock
Part Co., Ltd；Palpus extractive of usnea is purchased from Guangzhou Pin Yan Biotechnology Co., Ltd；Quercus suber bark extract, chicken feet
Mapler leaf extract is purchased from Guangzhou Rong Dao Chemical Co., Ltd..
Embodiment 1
A kind of pro-skin slow releasing composition is grouped as by the group of following weight number: 0.1g bis- (lauramide glutamine) relies
Propylhomoserin sodium, 10g lycium barbarum berry extract, 2g Echinacea angustifolia extract, 10g palpus extractive of usnea, 0.1g tetrahydro methylpyrimidine
Carboxylic acid.
Embodiment 2
A kind of pro-skin slow releasing composition is grouped as by the group of following weight number: 2g bis- (lauramide glutamine) relies ammonia
Sour sodium, 4g lycium barbarum berry extract, 5g Echinacea angustifolia extract, 5g palpus extractive of usnea, 1g tetrahydro methylpyrimidine carboxylic acid.
Embodiment 3
A kind of pro-skin slow releasing composition is grouped as by the group of following weight number: 1g bis- (lauramide glutamine) relies ammonia
Sour sodium, 7g lycium barbarum berry extract, 3.5g Echinacea angustifolia extract, 7.5g palpus extractive of usnea, 0.5g tetrahydro methylpyrimidine
Carboxylic acid.
Embodiment 4
A kind of pro-skin slow releasing composition is grouped as by the group of following weight number: 0.1g bis- (lauramide glutamine) relies
Propylhomoserin sodium, 10g lycium barbarum berry extract, 2g Echinacea angustifolia extract, 10g must extractive of usnea, 0.1g tetrahydro methylpyrimidine
Carboxylic acid, 5g Quercus suber bark extract.
Embodiment 5
A kind of pro-skin slow releasing composition is grouped as by the group of following weight number: 2g bis- (lauramide glutamine) relies ammonia
Sour sodium, 4g lycium barbarum berry extract, 5g Echinacea angustifolia extract, 5g palpus extractive of usnea, 1g tetrahydro methylpyrimidine carboxylic acid,
0.5g Acer palmatum leaf extract.
Embodiment 6
A kind of pro-skin slow releasing composition is grouped as by the group of following weight number: 1g bis- (lauramide glutamine) relies ammonia
Sour sodium, 7g lycium barbarum berry extract, 3.5g Echinacea angustifolia extract, 7.5g palpus extractive of usnea, 0.5g tetrahydro methylpyrimidine
Carboxylic acid, 0.5g Quercus suber bark extract, 3g Acer palmatum leaf extract.
Embodiment 7
A kind of moisturizing repair cream, is prepared by the component of following percentage composition:
A phase: -2 stearates of polyglycereol // stearine // stearyl alcohol 1.5g, arachidic alcohol // docosyl alcohol // arachidic alcohol
Glucoside 0.5g, tocopherol (vitamin E) 0.3g, saualane 1g, C13-16 isoparaffin 4g, jojoba seed oil 0.5g, sea-buckthorn
Seed oil 0.5g, dimethyl silicone polymer 2g；
B phase: water to 100g, Sodium Hyaluronate 0.04g, glycerol 5g, trehalose 2g, xanthan gum 0.1g, carbomer 0.15g；
C phase: arginine 0.14g, water 2g；
D phase: the composition 2g of embodiment 1.
Embodiment 8
A kind of moisturizing repair cream, is prepared by the component of following percentage composition:
A phase: -2 stearates of polyglycereol // stearine // stearyl alcohol 1g, arachidic alcohol // docosyl alcohol // arachidic alcohol Portugal
Glucosides 0.5g, tocopherol (vitamin E) 0.3g, lauric alcohol-caprylate/decylate 2g, C13-16 isoparaffin 2g, egg oil
0.5g；
B phase: water to 100g, Sodium Hyaluronate 0.04g, glycerol 5g, 1,3-PD 5g, trehalose 2g, xanthan gum 0.1g,
Carbomer 0.15g；
C phase: arginine 0.14g, water 2g；
D phase: the composition 2g of embodiment 4.
A kind of moisturizing repair cream of embodiment 7-8 the preparation method is as follows:
1. A is mixed and is heated to 80-85 DEG C, stirring and dissolving is uniform, heat preservation for standby use；
2. Sodium Hyaluronate, xanthan gum and the dispersion of carbomer glycerol in B phase are stirred evenly, B phase is then added
Other clouts, are heated to 90 DEG C or so after mixing evenly, and homogeneous uniform keeps the temperature 15-20min；
It is pumped into B phase 3. A phase is filtered, after mixing, stirring cools down homogeneous；
4. being cooled to 65 DEG C or so, C phase is added, stirs evenly, continues to cool down；
5. being cooled to 45 DEG C or so, D phase is added, stirs evenly, obtains moisturizing repair cream.
The moisturizing repair cream of embodiment 7-8 is in polarized light microscopy microscopic observation, it is possible to find forms stable layered liquid crystal knot
Structure.
Embodiment 9
A kind of moisturizing reparation cream, is prepared by the component of following percentage composition:
A phase: inulin lauryl carbamate 0.05g, sodium bacillus subtilis lipopeptide 0.1g, glycerol 3.15g；
B phase: tocopherol (vitamin E) 0.2g, C13-16 isoparaffin 3g, egg oil 0.3g, Queensland nut seed oil 2g；
C phase: water 0.6g；
D phase: water to 100g, Sodium Hyaluronate 0.02g, 1,3-PD 2g, trehalose 2g, xanthan gum 0.2g hydrogenate ovum
Phosphatidase 0 .05g；
E phase: the composition 0.5g of embodiment 2.
Embodiment 10
A kind of moisturizing reparation cream, is prepared by the component of following percentage composition:
A phase: inulin lauryl carbamate 0.1g, PEG-20 methyl sesquistearate 0.2g, glycerol 5g；
B phase: tocopherol (vitamin E) 0.5g, lauric alcohol-caprylate/decylate 2g, saualane 1g, Seabuckthorm Seed Oil 1g；
C phase: water 0.6g；
D phase: water to 100g, Sodium Hyaluronate 0.02g, 1,3-PD 2g, erythrite 1g, trehalose 2g, xanthan gum
0.2g, hydrolecithin 0.05g；
E phase: the composition 0.5g of embodiment 5.
A kind of moisturizing of embodiment 9-10 repair cream the preparation method is as follows:
1. A phase is uniformly mixed in advance, B phase is added and is uniformly mixed, adds C phase and stir to forming transparent D
Phase oleogel.
2. the Sodium Hyaluronate in D phase, the dispersion of xanthan gum 1,3-PD are stirred evenly, its of D phase is then added
Its clout is heated to 90 DEG C or so after mixing evenly, and homogeneous uniform, insulated and stirred 15-20min is cooled to 45 DEG C, and E phase is added,
It stirs evenly, forms water phase；
3. D phase oleogel is added in water phase, stirs evenly and appropriate homogeneous is up to moisturizing reparation cream.
The moisturizing of embodiment 9-10 repairs cream in polarized light microscopy microscopic observation, and the partial size of lotion is respectively less than 1 μm.
Embodiment 11
A kind of moisturizing reparation essence, is prepared by the component of following percentage composition:
A phase: inulin lauryl carbamate 0.1g, sodium bacillus subtilis lipopeptide 0.15g, glycerol 4.5g；
B phase: tocopherol (vitamin E) 0.1g, C13-16 isoparaffin 2g, egg oil 0.8g, jojoba seed oil 0.2g；
C phase: water to 100g, Sodium Hyaluronate 0.02g, glycerol 3g, glycine betaine 3g, xanthan gum 0.08g, carbomer 0.15g；
D phase: water 3g, arginine 0.13g；
E phase: the composition 2.5g of embodiment 3.
Embodiment 12
A kind of moisturizing reparation essence, is prepared by the component of following percentage composition:
A phase: sodium bacillus subtilis lipopeptide 0.2g, PEG-20 methyl sesquistearate 0.3g, glycerol 7g；
B phase: tocopherol (vitamin E) 0.2g, C13-16 isoparaffin 3g, egg oil 0.3g, Seabuckthorm Seed Oil 1g；
C phase: water to 100g, Sodium Hyaluronate 0.02g, glycerol 2g, erythrite 1g, glycine betaine 3g, xanthan gum 0.05g, card
Wave nurse 0.15g；
D phase: water 3g, arginine 0.13g；
E phase: the composition 2.5g of embodiment 6.
A kind of moisturizing of embodiment 11-12 repair essence the preparation method is as follows:
1. A phase is uniformly mixed in advance, B phase is added and is uniformly mixed, forms D phase oleogel.
2. the Sodium Hyaluronate in C phase, xanthan gum, the dispersion of carbomer glycerol are stirred evenly, its of C phase is then added
Its clout is heated to 90 DEG C or so after mixing evenly, and homogeneous uniform, insulated and stirred 15-20min is cooled to 60 DEG C, and D phase is added,
It stirs evenly, is cooled to 45 DEG C, E phase is added, stirs evenly, form water phase；
3. D phase oleogel is added in water phase, stirs evenly and appropriate homogeneous is up to moisturizing reparation essence.
The moisturizing of embodiment 11-12 repairs essence in polarized light microscopy microscopic observation, and the partial size of lotion is respectively less than 1 μm.
Comparative example 1
A kind of moisturizing repair cream, A, B, C phase are with embodiment 7,2g composition components that D phase is added are as follows: the Ningxia 10g Chinese holly
Fructus lycii extract, 2g Echinacea angustifolia extract, 10g palpus extractive of usnea, 0.1g tetrahydro methylpyrimidine carboxylic acid.
Preparation method is the same as embodiment 7.
Comparative example 2
A kind of moisturizing reparation cream, is prepared by the component of following percentage composition:
Cream is repaired in a kind of moisturizing, and A, B, C, D phase are with embodiment 9,0.5g composition components that E phase is added are as follows: 2.5g
Two (lauramide glutamine) Sodium lysinates, 3g lycium barbarum berry extract, 6g Echinacea angustifolia extract, 4g must sunglo extractions
Object, 2g tetrahydro methylpyrimidine carboxylic acid.
Preparation method is the same as embodiment 9.
Comparative example 3
A kind of moisturizing repair cream does not add the D phase (composition of embodiment 1) of embodiment 7, the same embodiment of preparation method
7。
Comparative example 4
A kind of moisturizing repair cream does not add the D phase (composition of embodiment 4) of embodiment 8, the same embodiment of preparation method
8。
Comparative example 5
A kind of moisturizing reparation cream, does not add the E phase (composition of embodiment 2) of embodiment 9, the same embodiment of preparation method
9。
Comparative example 6
A kind of moisturizing reparation cream, does not add the E phase (composition of embodiment 5) of embodiment 10, preparation method is the same as implementation
Example 10.
Comparative example 7
A kind of moisturizing reparation essence, does not add the E phase (composition of embodiment 3) of embodiment 11, preparation method is the same as real
Apply example 11.
Comparative example 8
A kind of moisturizing reparation essence, does not add the E phase (composition of embodiment 6) of embodiment 12, preparation method is the same as real
Apply example 12.
Efficacy assessments experiment
Experimental method:
The women of 70 dry skins, age in -30 years old 20 years old, are divided into 14 groups, and every group of 5 people use embodiment respectively
The sample of 7-12 and comparative example 1-8 are used continuously 28 days twice daily.
Using German CK skinanalysis apparatus Cutometer MPA 580 test keratoderma water content, through epidermis dehydration
(TEWL), without sunlight direct projection is unified in front of test, calm, 25 DEG C of room temperature, the indoor carry out subjects skin of humidity 50-60% is clear
It is clean, it is tested after the 15min that sits quietly, the same position of face is selected in measurement every time, and measurement three times, is averaged altogether.Exist respectively
The water content of subjects skin is measured after use at the end of 1st day 2h, 8h, 12h and experiment and through epidermis dehydration situation.
TEWL is for evaluating skin barrier function and using the important parameter of skin repair after product, and numerical value is smaller then
Skin barrier function is better, and repairing effect is better.
Keratoderma water content value added=(keratoderma water content-tested preceding keratoderma is aqueous after tested
Amount)/tested preceding keratoderma water content × 100%
Its test result is as shown in Table 1 and Table 2:
The variation (%) of 1 keratoderma water content of table
Can be seen that from the experimental data of table 1 using after product provided by embodiment 7-12, keratoderma it is aqueous
Amount increases, and is above 78% using water content value added after 2h, illustrates that the product of the application has quick moisturizing effect；And
Water content value added is above 50% after using 12h, illustrates the sustainable 12h of the moistening effect of product of the present invention, has and relatively holds
Long moistening effect.
After skin-protection product provided by comparative example 3-8, although keratoderma water content all increased,
Significantly lower than the value added of embodiment, and after using 12h, water content value added is lower, illustrates the composition of the application
Has the function of pro-skin sustained release, can make active constituent is continuously percutaneous absorption, is promoted and continues moistening effect.
Comparative example 1 illustrates two (lauramide glutamine) in the application composition compared with the result of embodiment 7
It when Sodium lysinate and other compositions are used in compounding, can ensure that active constituent is continuously percutaneous absorption, improve active constituent
Bioavailability, to promote the moisturizing moisture holding capacity of skin；Comparative example 2 is compared with the experimental result of embodiment 9, explanation
Only when composition of the invention is compounded according to specific ratio, preferable moistening effect could be obtained.
Table 2 smears the TEWL average value of the skin after different samples
From the results shown in Table 2, the cosmetics of the embodiment 7-12 containing the present composition have quick, potent
Repairing effect, be substantially less than the TWEL value before use using skin TEWL value after 2h, and before being still below use after using 12h
TWEL value make skin TEWL value be close to skin normal status value containing cosmetics of the invention by use in 28 days.
Without the cosmetics of the present composition, after using 12h, skin TEWL value is substantially unchanged, after using 28 days, TEWL
The decline degree of value is also significantly lower than the decline degree of embodiment.1 data of table illustrate that the synergistic effect of the present composition can be right
Skin carries out water lock moisturizing, can preferably reinforce skin barrier function, so that the repairing effect of cosmetics reaches best.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (9)
1. a kind of pro-skin slow releasing composition, which is characterized in that the composition mainly includes two (lauramides of 0.1-2 parts by weight
Glutamine) Sodium lysinate, the lycium barbarum berry extract of 4-10 parts by weight, the Echinacea angustifolia extract of 2-5 parts by weight, 5-10
The tetrahydro methylpyrimidine carboxylic acid of the palpus extractive of usnea of parts by weight, 0.1-1 parts by weight.
2. a kind of pro-skin slow releasing composition according to claim 1, which is characterized in that the composition further includes 0.5-5 weight
Measure the Quercus suber bark extract of part.
3. a kind of pro-skin slow releasing composition according to claim 1, which is characterized in that the composition further includes 0.5-3 weight
Measure the Acer palmatum leaf extract of part.
4. a kind of cosmetics, which is characterized in that include the described in any item pro-skin slow releasing compositions of claim 1-3 and cosmetics
Acceptable auxiliary agent；It is in terms of 100% by the weight of the cosmetics, the pro-skin slow releasing composition accounts for cosmetics total weight
0.5-5%.
5. cosmetics according to claim 4, which is characterized in that the auxiliary agent mainly contains surfactant, polyalcohol, oil
Rouge；It is in terms of 100% by the weight of the cosmetics, the surfactant accounts for the 0.15-2% of cosmetics total weight, and polyalcohol accounts for
5-10%, grease account for 3-8%.
6. cosmetics according to claim 5, which is characterized in that the surfactant is PEG-20 methyl sesquialter
Stearate, sodium bacillus subtilis lipopeptide, inulin lauryl carbamate, -2 stearate of polyglycereol, stearine, tristearin
One or more of alcohol, arachidic alcohol, docosyl alcohol, arachidic alcohol glucoside.
7. cosmetics according to claim 5, which is characterized in that the polyalcohol is 1,3-PD, erythrite, glycerol
One or more of.
8. cosmetics according to claim 5, which is characterized in that the grease be lauric alcohol-caprylate/decylate,
One or more of C13-16 isoparaffin, saualane, jojoba seed oil, Seabuckthorm Seed Oil, egg oil, Queensland nut seed oil.
9. cosmetics according to claim 5, which is characterized in that the cosmetics are essence or lotion or cream.
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| WO2022136899A1 (en) * | 2020-12-22 | 2022-06-30 | L V M H Recherche | Oil balm cleansing cosmetic composition |
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| CN114796059A (en) * | 2022-05-27 | 2022-07-29 | 湖州嘉亨实业有限公司 | Moisturizing and repairing composition, skin care product and preparation method of skin care product |
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| CN115645334A (en) * | 2022-11-15 | 2023-01-31 | 英中再生医学(山东)有限公司 | Moisturizing and anti-aging cosmetic and preparation method thereof |
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