CN103330658B - Skin care composition with functions of repairing damaged skin surface lipid film and relieving skin pressure - Google Patents
Skin care composition with functions of repairing damaged skin surface lipid film and relieving skin pressure Download PDFInfo
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Abstract
The invention relates to a skin care composition with functions of repairing damaged skin surface lipid films and relieving skin pressure. The skin care composition is prepared from the following raw materials in percentage by weight: 5%-10% of oilseed rape sterol, 6%-18% of N-palmitoyl hydroxyproline spermaceti wax ester, 0.05%-0.5% of stearic acid, 0.5%-2.0% of bisabolol and the balance of tocopheryl acetate, wherein the weight percentage sum of the raw materials is 100%. The raw materials for preparing the skin care composition are selected from conventional raw materials in the field of skin care products. The skin care composition prepared through the scientific composition of the raw materials by an inventor has the advantages of effectively repairing damaged skin surface lipid films, increasing the moisture content in skins and reducing the irritability rate of the skins.
Description
Technical field
The present invention relates to a kind of have repair impaired sebum film, the skin care compositions of skin pressure of releiving and the application in skin care field thereof.
Background technology
Skin say to keep flexible smooth, mainly because containing a certain amount of moisture in skin histology, add that the oils and fats of the smegma in skin and the perspiration of sweat gland secretion mix, the very thin film of one deck is formed at skin surface, medically be referred to as " sebum film ", it can be moistened skin, can reduce again the evaporation of moisture in skin histology greatly.Once sebum film is destroyed, not only water retaining function reduces, and skin also can be made to become dry, and pruritus is even casted off a skin.Also weaken the reagency of the factors such as weather thereupon, very easily cause skin red and swollen, local is general redly even there is sensitivity phenomenon.Especially easily occur pigementation, skin is pale not.Also can feel after clean that skin is than dry and astringent tight time healthy.Present society, along with environmental pollution constantly increases with the chemicals contacted, skin sebum film is damaged, various responsive skin and irritated skin constantly increase.
Summary of the invention
Technical problem to be solved by this invention be to provide a kind of have repair impaired sebum film, the skin care compositions of skin pressure of releiving and the application in skin care field thereof.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of have the skin care compositions repairing impaired sebum film, skin pressure of releiving, described compositions is made up of the raw material of following percentage by weight: campesterol 5-10%, N-palmityl hydroxyproline cetyl 6-18%, stearic acid 0.05-0.5%, bisabolol 0.5-2.0%, tocopherol acetas to 100%; Wherein, the percentage by weight sum of above-mentioned raw materials is 100%.
Produce synergism between above-mentioned each raw material, thus effectively can repair sebum film, skin pressure of releiving.
The brief introduction of each raw material effect is as follows:
Tocopherol acetas: tocopherol acetas is also known as vitamin E; in body metabolic processes, prevent the readily oxidizable substance such as unsaturated fatty acid in cell membrane and cell oxidized; thus Cell protection film complete and then prevent old and feeble effect, the normal function of genitals can be kept.Vitamin E has stronger reproducibility, can be used as antioxidant.As antioxidant in body, eliminate interior free yl, reduce ultraviolet to the injury of human body.
Brassica campestris L (BRASSICACAMPESTRIS) sterol: the one being plant sterol, to skin, there is very high permeability, skin surface moisture content can be kept, promote skin metabolism, suppress scytitis, can anti-sunburn, skin aging, also have effect of hair growth promoting, hair care.Can be used as w/o type emulsifying agent, for the production of cream frost, there is use sense good (auxiliary malleability is good, smooth does not glue), good endurance, the feature such as not perishable.Meanwhile, can also cell signalling be carried out, promote sebum film reparation.
N-palmityl hydroxyproline cetyl: N-palmityl hydroxyproline cetyl is close with the ceramide structure of matter forming keratodermatitis; skin can be penetrated into very soon; combine with the water in horny layer; form a kind of network structure; pin moisture; play the important function preventing moisture from distributing and outside stimulus is had to safeguard function, carry protection skin and moist, moisture-keeping functions.Also there are many research reports to point out, by using the external plaster series products containing ceramide, the effect of object and the check melanin brown patch preventing anaphylaxis dermatosis can be reached.
Stearic acid: stearic acid is the free fatty in sebum film, can suppress the growth of some invasive organism, has self-purification to skin.Meanwhile, can also keep skin moisturizing, the water oil balance of regulation of skin self, safeguards the normal formation of sebum film.
Bisabolol: a-bisabolol is mainly used in skin care and skin care cosmetics; a-bisabolol as active component with protection and nursing allergic skin; efficiently can suppress IL-1 α comprehensively; PGE2; LTB4; the points such as TNF α wait inflammation medium, the stress state of skin of effectively releiving.
The invention has the beneficial effects as follows: the main component of the tocopherol acetas in the present invention, Brassica campestris L (BRASSICACAMPESTRIS) sterol, N-palmityl hydroxyproline cetyl, stearic acid simulated skin horny layer molecular film, can rapidly recombination classes like the lipid bilayer of skin self, efficient reparation skin, improve the irritation ability of skin, reduce skin sensitivity, improve skin lock waterpower simultaneously.The points such as neutral red bisabolol has efficient antiinflammatory composition, efficiently can suppress IL-1 α comprehensively, PGE2, LTB4, TNF α wait inflammation medium, the stress state of skin of effectively releiving.
The better percentage by weight of each raw material of described skin care compositions is:
Brassica campestris L (BRASSICACAMPESTRIS) sterol: 6-8%; N-palmityl hydroxyproline cetyl: 8-15%; Stearic acid: 0.1-0.4%; Bisabolol: 0.8-1.2%; Tocopherol acetas to 100%; Wherein, the percentage by weight sum of above-mentioned raw materials is 100%.
The optimum weight percentage ratio of each raw material of described skin care compositions is:
Brassica campestris L (BRASSICACAMPESTRIS) sterol: 7%; N-palmityl hydroxyproline cetyl: 10%; Stearic acid: 0.2%; Bisabolol: 1.0%; Tocopherol acetas 81.8%.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of have the application of skin care compositions in skin care field of repairing impaired sebum film, skin pressure of releiving.Skin care compositions of the present invention can adjuvant acceptable with skin care field, as water, glycerol equal solvent, the emulsifying agent such as sorbitan stearate, polysorbate-60, caprylic/capric triglyceride, Butyrospermum Parkii wet goods emollient and the thickening agent such as carbomer, HANSHENGJIAO composition skin care formulation, described skin care formulation can be applicable to skin care field.
Different according to use approach, skin care compositions of the present invention can prepare various external preparation, external facial cream, emulsion, essence, hand cream and massage cream etc.But be not limited to above-mentioned dosage form, according to method known in skin care field, above-mentioned composition can be made various different external preparation by known method.
The preparation for repairing that the present invention makes is soft, non-stimulated.Its usage and consumption as follows:
Method: after clean of every day, the external preparation that on skin prepared by the appropriate the present invention of uniform application, sooner or later respectively once; Also can be used as massage cream to use, use 1-2 time weekly;
Consumption: according to individual demand on ordinary days nursing use, smear invention formulation in right amount.Use as massage cream, consumption can be increased in right amount.
The invention has the beneficial effects as follows:
Raw material selection skin care field convenient source of the present invention, inventor carries out scientific composition to raw material, utilizes the synergism between each component, can effectively repair impaired sebum film, improves skin moisture content, reduces skin allergy rate.
Accompanying drawing explanation
Fig. 1 is experimenter at use blank sample and uses repair cream skin moisture content curve chart after two hours, 7 days, 14 days, 21 days.
Detailed description of the invention
Be described principle of the present invention and feature below in conjunction with accompanying drawing, example, only for explaining the present invention, is not intended to limit scope of the present invention.
Embodiment 1:
Have the skin care compositions repairing impaired sebum film, skin pressure of releiving, described compositions is made up of the raw material of following percentage by weight: Brassica campestris L (BRASSICACAMPESTRIS) sterol: 5%; N-palmityl hydroxyproline cetyl: 10%; Stearic acid: 0.3%; Bisabolol: 2.0%; Tocopherol acetas 82.7%.
Embodiment 2:
Have the skin care compositions repairing impaired sebum film, skin pressure of releiving, described compositions is made up of the raw material of following percentage by weight: Brassica campestris L (BRASSICACAMPESTRIS) sterol: 7%; N-palmityl hydroxyproline cetyl: 14%; Stearic acid: 0.5%; Bisabolol: 1.5%; Tocopherol acetas 77.0%.
Embodiment 3:
Have the skin care compositions repairing impaired sebum film, skin pressure of releiving, described compositions is made up of the raw material of following percentage by weight: Brassica campestris L (BRASSICACAMPESTRIS) sterol: 8%; N-palmityl hydroxyproline cetyl: 18%; Stearic acid: 0.15%; Bisabolol: 0.5%; Tocopherol acetas 73.35%.
Embodiment 4:
Have the skin care compositions repairing impaired sebum film, skin pressure of releiving, described compositions is made up of the raw material of following percentage by weight: Brassica campestris L (BRASSICACAMPESTRIS) sterol: 10%; N-palmityl hydroxyproline cetyl: 6%; Stearic acid: 0.05%; Bisabolol: 1.0%; Tocopherol acetas 82.95%.
The present invention is further illustrated below by way of concrete test example.
The above-mentioned repair cream human skin patch of concrete test example 1
Materials and methods
1. tested material: the preparation of repair cream:
Component A: sorbitan stearate 1.5g, polysorbate-601.5g, caprylic/capric triglyceride 4g, glyceryl monostearate 2g, cetearyl alcohol 5g, shea butter 1g, polydimethylsiloxane 2g, Dormant oils 5.0g.
B component: glycerol 5g, butanediol 3g, xanthan gum 0.2g, deionized water 61.5g.
C component: the skin care compositions 8g that embodiment 1 obtains.
D component: floral perfume 0.1g, Methylisothiazolinone 0.2g.
Preparation method: component A mixed and be heated to 80 DEG C, is incubated 20 minutes; B component mixes and is heated to 80 DEG C, is incubated 20 minutes.
B component added in component A, homogenizing stirs, and 80 DEG C are incubated 10 minutes.
Be cooled to 55 DEG C, add C component.
Be cooled to 45 DEG C, add D component.
Be cooled to 35 DEG C, discharging, fill obtains repair cream.
2. negative control: blank
3. experimenter: totally 30 people, male 15 people, female 15 people, at 21 ~ 50 years old age, meets experimenter and volunteers inclusion criteria.
4. patch method: select qualified speckle examination device, with closed patch test method, tested material is about 0.03g(mastic) be applied in speckle examination device, external special adhesive tape sticks in experimenter back, tested material is removed after 24 hours, within after removing respectively 0.5,24,48 hour, observe dermoreaction, by its result of dermoreaction grade scale record in " cosmetics health specification " (version in 2007).Result of the test is in table 1:
Table 1 human skin patch result
Human skin patch result shows: in 30 people, skin adverse reaction appears in 0 example; Illustrate that product of the present invention is safe to use.
The above-mentioned repair cream clinical effectiveness test of concrete test example 2
1. experimenter: have dry and cracked in various degree with skin, particularly face have occurred that impaired 30 people of the sebum films such as dry peeling are for subjects, wherein, and female 15 example, man 15 example.Age, test lasted 14 days from 21 ~ 50 years old.
2. trial method: be often coated with 1 ~ 2 above-mentioned repair cream of embodiment 1 beyond the highest heavens, smear the face that position is dry peeling.
Above-mentioned for embodiment 1 repair cream is applied in skin after 2 hours skin become soft, prodding and itching feeling obviously reduces, and has 24 examples (80%), on probation after 7 days skin urtication sense disappear, have 28 examples (93%) without skin effect phenomenon.On probation after 14 days, skin is without dry skin effect phenomenon, and skin all recovers Natural Water profit state.
Test example 3: the evaluation of moisture-keeping efficacy
One, experimental principle
Human experimentation, by particular experiment, crowd forms test population, and test subject uses the change preparing moisture of skin and moisture loss before and after skin care item, determines the moisture-keeping efficacy of skin care item, thus infers that product repairs the effect of impaired sebum film.
Two, experimental apparatus
Moisture content of skin test Corneometer CM825.
Three, Subject Population and the testing time
Have dry and cracked in various degree with skin, particularly face has occurred that impaired 30 people of the sebum films such as dry peeling are for subjects, wherein, and female 15 example, man 15 example.Age, test lasted 21 days from 21 ~ 50 years old.
Four, experimental technique
1. select the left and right cheek of experimenter cycle labeling successively;
2. use moisture content of skin to test Corneometer CM825 by technical staff to test the cheek not smearing repair cream, average, be designated as blank value.
3. smear repair cream sample (with test example 1) at experimenter's cheek Test sites, blank tested region does not use any cosmetics.
4. experimenter is using repair cream after two hours, 7 days, 14 days, 21 days continuously, uses moisture content of skin to test Corneometer CM825 measure 5 times, average by technical staff.
5. add up the numerical value that subject position records at every turn, analyze its skin moisture content Changing Pattern.
Five, experimental result
As shown in Figure 1, wherein Fig. 1 is experimenter at use blank sample and uses repair cream skin moisture content curve chart after two hours, 7 days, 14 days, 21 days result; As can be seen from Figure 1, repair cream sample makes moisture content of skin increase, and moistening effect is remarkable, can effectively repair impaired sebum film.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (4)
1. one kind has the skin care compositions repairing impaired sebum film, skin pressure of releiving, it is characterized in that, described compositions is made up of the raw material of following percentage by weight: campesterol 5-10%, N-palmityl hydroxyproline cetyl 6-18%, stearic acid 0.05-0.5%, bisabolol 0.5-2.0%, tocopherol acetas to 100%; Wherein, the percentage by weight sum of above-mentioned raw materials is 100%.
2. according to claim 1 have the skin care compositions repairing impaired sebum film, skin pressure of releiving, it is characterized in that, described compositions is made up of the raw material of following percentage by weight: campesterol 6-8%, N-palmityl hydroxyproline cetyl 8-15%, stearic acid 0.1-0.4%, bisabolol 0.8-1.2%, tocopherol acetas to 100%; Wherein, the percentage by weight sum of above-mentioned raw materials is 100%.
3. according to claim 1 have the skin care compositions repairing impaired sebum film, skin pressure of releiving, it is characterized in that, described compositions is made up of the raw material of following percentage by weight: campesterol 7%, N-palmityl hydroxyproline cetyl 10%, stearic acid 0.2%, bisabolol 1.0%, tocopherol acetas 81.8%.
4. having described in an any one of claims 1 to 3 repairs impaired sebum film, the skin care compositions of skin pressure of releiving is preparing the application in skin care item.
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| CN201310255765.5A CN103330658B (en) | 2013-06-25 | 2013-06-25 | Skin care composition with functions of repairing damaged skin surface lipid film and relieving skin pressure |
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| CN201310255765.5A CN103330658B (en) | 2013-06-25 | 2013-06-25 | Skin care composition with functions of repairing damaged skin surface lipid film and relieving skin pressure |
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| CN103330658B true CN103330658B (en) | 2015-06-17 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103877102B (en) * | 2014-04-10 | 2016-01-20 | 上海紫邦生物医药有限公司 | Plant sterol or its ester/bisabolol are preparing the application in antiinflammatory repair medicine |
| CN103948532B (en) * | 2014-05-13 | 2016-06-15 | 张贺 | A kind of cosmetics of replenishing water and preserving moisture skin of releiving and preparation method thereof |
| CN105496825A (en) * | 2016-01-20 | 2016-04-20 | 广州丹奇日用化工厂有限公司 | Cleansing cream capable of repairing damaged hydrolipidic film and preparation method thereof |
| CN109568231A (en) * | 2018-12-30 | 2019-04-05 | 广州瑞誉化工科技有限公司 | It is a kind of can Red blood streak dispelling skin composition and its preparation method and application |
| CN110448486B (en) * | 2019-08-14 | 2021-06-11 | 广州睿晞生化科技有限公司 | Essential oil capable of repairing damaged sebum membrane |
| CN110652477A (en) * | 2019-08-15 | 2020-01-07 | 广州欧盛化妆品有限公司 | Infant repair cream |
| CN111265461A (en) * | 2020-03-26 | 2020-06-12 | 上海绿瑞生物科技有限公司 | Water-oil dual-phase composition with allergy-relieving and repairing functions, preparation and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2008520630A (en) * | 2004-11-22 | 2008-06-19 | シムライズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・コンパニー・コマンジツト・ゲゼルシヤフト | Formulation containing ceramide and / or pseudo-ceramide effective for skin damage and (α-) bisabolol |
| GB0912481D0 (en) * | 2009-07-17 | 2009-08-26 | Reckitt Benckiser Healthcare I | Skincare compositions |
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Non-Patent Citations (1)
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| 佚名."SymRepair？;153884德肤修".《百度空间,http://hi.baidu.com/zg_chen/item/35c3b8c6a5cfe16bf7c95d5a》.2010,第1页第1-12行. * |
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