CN114224766A - Oil control composition, application of oil control composition in cosmetics, cosmetics and preparation method of oil control composition - Google Patents
Oil control composition, application of oil control composition in cosmetics, cosmetics and preparation method of oil control composition Download PDFInfo
- Publication number
- CN114224766A CN114224766A CN202210010537.0A CN202210010537A CN114224766A CN 114224766 A CN114224766 A CN 114224766A CN 202210010537 A CN202210010537 A CN 202210010537A CN 114224766 A CN114224766 A CN 114224766A
- Authority
- CN
- China
- Prior art keywords
- oil control
- control composition
- cosmetics
- oil
- cosmetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 64
- 239000002537 cosmetic Substances 0.000 title claims abstract description 62
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000002904 solvent Substances 0.000 claims abstract description 23
- 239000003755 preservative agent Substances 0.000 claims abstract description 13
- 239000002562 thickening agent Substances 0.000 claims abstract description 13
- 230000002335 preservative effect Effects 0.000 claims abstract description 10
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- -1 azelaic acid amino acid derivatives Chemical class 0.000 claims description 17
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 15
- 235000003704 aspartic acid Nutrition 0.000 claims description 15
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 15
- 229960002446 octanoic acid Drugs 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- BDJRBEYXGGNYIS-UHFFFAOYSA-N Nonanedioid acid Natural products OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims description 12
- 239000011259 mixed solution Substances 0.000 claims description 12
- OWVLYQRCCIEOPF-QHTZZOMLSA-L zinc;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Zn+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 OWVLYQRCCIEOPF-QHTZZOMLSA-L 0.000 claims description 12
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 7
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 6
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 6
- 235000010493 xanthan gum Nutrition 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- 229940082509 xanthan gum Drugs 0.000 claims description 6
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 5
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 5
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 5
- 229960005323 phenoxyethanol Drugs 0.000 claims description 5
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims description 4
- 229960001631 carbomer Drugs 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 4
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 claims description 3
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 3
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 claims description 3
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 claims description 3
- 229920002148 Gellan gum Polymers 0.000 claims description 3
- BVTHRGZMQHOCOL-UHFFFAOYSA-N OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO Chemical compound OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO BVTHRGZMQHOCOL-UHFFFAOYSA-N 0.000 claims description 3
- 229920001090 Polyaminopropyl biguanide Polymers 0.000 claims description 3
- 235000010489 acacia gum Nutrition 0.000 claims description 3
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 3
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 3
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims description 3
- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 239000000679 carrageenan Substances 0.000 claims description 3
- 229920001525 carrageenan Polymers 0.000 claims description 3
- 229940113118 carrageenan Drugs 0.000 claims description 3
- 229960003993 chlorphenesin Drugs 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 3
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 3
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 3
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- 235000010492 gellan gum Nutrition 0.000 claims description 3
- 239000000216 gellan gum Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 3
- 229940093424 polyaminopropyl biguanide Drugs 0.000 claims description 3
- 239000004302 potassium sorbate Substances 0.000 claims description 3
- 235000010241 potassium sorbate Nutrition 0.000 claims description 3
- 229940069338 potassium sorbate Drugs 0.000 claims description 3
- 229960003415 propylparaben Drugs 0.000 claims description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 3
- 235000010234 sodium benzoate Nutrition 0.000 claims description 3
- 239000004299 sodium benzoate Substances 0.000 claims description 3
- 229960003885 sodium benzoate Drugs 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 239000000686 essence Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 48
- 210000002374 sebum Anatomy 0.000 abstract description 22
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 abstract description 17
- 230000002401 inhibitory effect Effects 0.000 abstract description 12
- 230000028327 secretion Effects 0.000 abstract description 12
- 210000001732 sebaceous gland Anatomy 0.000 abstract description 11
- 238000012360 testing method Methods 0.000 description 12
- 230000005764 inhibitory process Effects 0.000 description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 208000020154 Acnes Diseases 0.000 description 4
- 229960003473 androstanolone Drugs 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 239000002390 adhesive tape Substances 0.000 description 3
- QFYNUCAKHMSPCY-UHFFFAOYSA-L disodium;nonanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CCCCCCCC([O-])=O QFYNUCAKHMSPCY-UHFFFAOYSA-L 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000001815 facial effect Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 239000003098 androgen Substances 0.000 description 2
- 229940030486 androgens Drugs 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 208000013403 hyperactivity Diseases 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
- GYUKEMYHXWICKF-DKWTVANSSA-N (2s)-2-aminobutanedioic acid;calcium Chemical compound [Ca].OC(=O)[C@@H](N)CC(O)=O GYUKEMYHXWICKF-DKWTVANSSA-N 0.000 description 1
- 229940035437 1,3-propanediol Drugs 0.000 description 1
- LKLYETYHDMXRAF-UHFFFAOYSA-N 2-octanoyloxybenzoic acid Chemical compound CCCCCCCC(=O)OC1=CC=CC=C1C(O)=O LKLYETYHDMXRAF-UHFFFAOYSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 108010008488 Glycylglycine Proteins 0.000 description 1
- SAVLIIGUQOSOEP-UHFFFAOYSA-N N-octanoylglycine Chemical compound CCCCCCCC(=O)NCC(O)=O SAVLIIGUQOSOEP-UHFFFAOYSA-N 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- ACFIXJIJDZMPPO-UHFFFAOYSA-N beta-NADPH Natural products C1=CCC(C(=O)N)=CN1C1C(O)C(O)C(COP(O)(=O)OP(O)(=O)OCC2C(C(OP(O)(O)=O)C(O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-UHFFFAOYSA-N 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229940034055 calcium aspartate Drugs 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- LHBCBDOIAVIYJI-DKWTVANSSA-L copper;(2s)-2-aminobutanedioate Chemical compound [Cu+2].[O-]C(=O)[C@@H](N)CC([O-])=O LHBCBDOIAVIYJI-DKWTVANSSA-L 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- RTMGQVSGXYZVTE-UHFFFAOYSA-L dipotassium;nonanedioate Chemical compound [K+].[K+].[O-]C(=O)CCCCCCCC([O-])=O RTMGQVSGXYZVTE-UHFFFAOYSA-L 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 210000000918 epididymis Anatomy 0.000 description 1
- 201000010063 epididymitis Diseases 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229960001983 magnesium aspartate Drugs 0.000 description 1
- SWHAQEYMVUEVNF-UHFFFAOYSA-N magnesium potassium Chemical compound [Mg].[K] SWHAQEYMVUEVNF-UHFFFAOYSA-N 0.000 description 1
- CRSJYWPXKKSOCQ-CBAPHJFVSA-L magnesium;(2s)-2-aminobutanedioate;hydron;tetrahydrate Chemical compound O.O.O.O.[Mg+2].[O-]C(=O)[C@@H](N)CC(O)=O.[O-]C(=O)[C@@H](N)CC(O)=O CRSJYWPXKKSOCQ-CBAPHJFVSA-L 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229940068988 potassium aspartate Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- WTWSHHITWMVLBX-DKWTVANSSA-M sodium;(2s)-2-aminobutanedioate;hydron Chemical compound [Na+].[O-]C(=O)[C@@H](N)CC(O)=O WTWSHHITWMVLBX-DKWTVANSSA-M 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- WYWWVJHQDVCHKF-RRCRMIRUSA-J tetrasodium;[(2r,3r,4r,5r)-2-(6-aminopurin-9-yl)-5-[[[[(2r,3s,4r,5s)-5-(3-carbamoyl-4h-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl]oxymethyl]-4-hydroxyoxolan-3-yl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].C1=CCC(C(=O)N)=CN1[C@@H]1[C@H](O)[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@@H]2[C@H]([C@@H](OP([O-])([O-])=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 WYWWVJHQDVCHKF-RRCRMIRUSA-J 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 229940062776 zinc aspartate Drugs 0.000 description 1
- POEVDIARYKIEGF-CEOVSRFSSA-L zinc;(2s)-2-aminobutanedioate;hydron Chemical compound [Zn+2].[O-]C(=O)[C@@H](N)CC(O)=O.[O-]C(=O)[C@@H](N)CC(O)=O POEVDIARYKIEGF-CEOVSRFSSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to an oil control composition, application thereof in cosmetics, cosmetics and a preparation method thereof, wherein the oil control composition comprises the following components in percentage by weight: 1.0-20.0 parts of oil control active factor, 0.01-1.0 part of preservative, 0.1-2.0 parts of thickening agent and 77.0-98.89 parts of solvent. The oil control composition can inhibit the activity of 5-alpha reductase, thereby inhibiting the hyperfunction of sebaceous glands, inhibiting the excessive secretion of sebum, and keeping the skin in a healthy state, and has very good oil control effect and very high safety. The application of the oil control composition in cosmetics not only improves the oil control performance of the cosmetics, but also ensures that the cosmetics have good safety. The cosmetic has the advantages of good oil control effect, high reliability, good safety, strong applicability and the like. The preparation method has the advantages of simplicity, convenient operation, convenient realization, stable preparation process, good preparation effect, capability of obtaining the oil-control composition with good quality and the like.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an oil control composition, application thereof in cosmetics, cosmetics and a preparation method.
Background
The skin is the largest organ of the human body, is used as the first barrier of the immune system of the human body, has the function of resisting external stimulation and simultaneously has the functions of perception and metabolism. Sebaceous glands are widely distributed on the skin, and sebum and sweat secreted by the sebaceous glands form a sebaceous membrane on the surface of a human body, which is one of important components of a first barrier of the human body. Sebum secretion is affected by androgens (especially dihydrotestosterone DHT), which over-secretion of androgens leads to an increase in sebaceous gland function, causing excessive sebum secretion. Excessive sebum secretion is one of the main causes of acne production, which can destroy the healthy skin state, have certain influence on the normal function of the skin, influence the beauty of the skin and bring certain trouble to the activities of daily life.
The 5-alpha reductase is a main catalyst participating in the formation of Dihydrotestosterone (DHT), the production of DHT is influenced by enzyme activity, the higher the activity of the enzyme is, the stronger the promotion effect on the formation of DHT is, and further, the sebaceous gland is hyperfunction, excessive sebum is produced, and the health of skin is influenced. Clinically, inhibition of 5-alpha reductase activity is one of the means for treating skin diseases such as acne, seborrheic dermatitis, alopecia, etc.
With the rapid development of social economy and the improvement of life quality, people pay more and more attention to the skin care, so that products with definite effect, pertinence, safety and no adverse reaction and capable of inhibiting excessive sebum secretion are very needed.
Disclosure of Invention
The present invention has been made to solve the above problems and disadvantages, and an object of the present invention is to provide an oil-controlling composition, which can inhibit the activity of 5-alpha reductase, thereby inhibiting the hyperactivity of sebaceous glands, inhibiting the excessive secretion of sebum, and maintaining the skin in a healthy state, and which has a very good oil-controlling effect and high safety, and a cosmetic using the same, and a method for preparing the same. The application of the oil control composition in cosmetics not only improves the oil control performance of the cosmetics, but also ensures that the cosmetics have good safety. The cosmetic has the advantages of good oil control effect, high reliability, good safety, strong applicability and the like. The preparation method has the advantages of simplicity, convenient operation, convenient realization, stable preparation process, good preparation effect, capability of obtaining the oil-control composition with good quality and the like.
The technical scheme of the invention is realized as follows:
the oil control composition is characterized by comprising the following components in percentage by weight: 1.0-20.0 parts of oil control active factor, 0.01-1.0 part of preservative, 0.1-2.0 parts of thickening agent and 77.0-98.89 parts of solvent; the oil control active factor is one or the combination of more than two of azelaic acid amino acid derivatives, aspartic acid and derivatives thereof, zinc pyrrolidone carboxylate, caprylic acid and derivatives thereof.
Preferably, in the oil control active factor, the weight percentage of the azelaic acid amino acid derivative is 60-90%, and the weight percentage of the sum of the aspartic acid and the derivatives thereof, the zinc pyrrolidone carboxylate and the caprylic acid and the derivatives thereof is 10-40%; the weight ratio of the aspartic acid and the derivatives thereof to the zinc pyrrolidone carboxylate and the octanoic acid and the derivatives thereof is 1-5: 1.
Preferably, in the oil control active factor, the weight percentage of the azelaic acid amino acid derivative is 75-85%, and the weight percentage of the sum of the aspartic acid and the derivatives thereof, the zinc pyrrolidone carboxylate and the caprylic acid and the derivatives thereof is 15-25.
Preferably, the preservative is one or a combination of more than two of methyl paraben, ethyl paraben, propyl paraben, phenoxyethanol, sodium benzoate, potassium sorbate, chlorphenesin, iodopropynyl butylcarbamate, polyaminopropyl biguanide and bis (hydroxymethyl) imidazolidinyl urea.
Preferably, the thickener is one or a combination of more than two of xanthan gum, arabic gum, carrageenan, gellan gum, hydroxyethyl cellulose, hydroxypropyl methyl cellulose and carbomer.
Preferably, the solvent is one or a combination of more than two of water, ethanol, glycerol, propylene glycol, methyl propylene glycol, butanediol, 1, 3-propanediol, dipropylene glycol, 1, 2-pentanediol and 1, 2-hexanediol.
An application of the oil control composition in preparing cosmetics.
The cosmetic is characterized by comprising the oil-control composition and cosmetic accessories, wherein the oil-control composition accounts for 1.0-30% by mass, and the cosmetic accessories account for 70-99% by mass.
Preferably, the cosmetic comprises a lotion, serum, emulsion, cream, mask, gel or spray.
The preparation method of the oil control composition is characterized by comprising the following steps:
(a) placing 80% of solvent in stirring equipment, adding the thickening agent into the solvent at a stirring speed of 1500 +/-500 revolutions per minute, stirring for 10-20 minutes, and then heating to 85 +/-5 ℃;
(b) uniformly mixing the preservative with the rest 20% of solvent, then adding the mixture into the mixed solution in the step (a), then adding the oil-controlling active factor into the mixed solution, and stirring for 15-20 minutes;
(c) and (c) cooling the mixed solution obtained in the step (b) to room temperature under the condition of keeping the stirring speed of 1500 +/-500 revolutions per minute, and filtering the mixed solution through 800-mesh filter cloth to obtain the oil control composition.
The invention has the beneficial effects that: (1) the oil control composition can inhibit the activity of 5-alpha reductase, thereby inhibiting the hyperfunction of sebaceous glands, inhibiting the excessive secretion of sebum, and keeping the skin in a healthy state, and has very good oil control effect and very high safety.
(2) The oil-controlling composition is applied to the preparation of cosmetics, so that cosmetics having excellent oil-controlling effect can be obtained, and the applicability and safety of the application are excellent.
(3) The oil control composition and the cosmetic auxiliary materials are combined into the cosmetic, so that the cosmetic has very good oil control performance, and the quality of the cosmetic is improved. The oil control composition and the cosmetic auxiliary materials are quite reasonable in proportion, the cosmetics are low in irritation, and can inhibit sebum secretion of sebaceous glands and prevent acnes and acnes. The cosmetic has the advantages of good oil control effect, high reliability, good safety, strong applicability and the like.
(4) The preparation method is very simple, which can be operated and realized by workers conveniently, and can ensure that the preparation of the oil-controlling composition is very stable, the preparation method has very good preparation effect, the oil-controlling composition with very good quality can be obtained, and the reliability and the applicability of the preparation method are very good.
Detailed Description
The first embodiment is as follows:
the invention relates to an oil control composition, which comprises the following components in percentage by weight: 1.0-20.0 parts of oil control active factor, 0.01-1.0 part of preservative, 0.1-2.0 parts of thickening agent and 77.0-98.89 parts of solvent; the oil control active factor is one or the combination of more than two of azelaic acid amino acid derivatives, aspartic acid and derivatives thereof, zinc pyrrolidone carboxylate, caprylic acid and derivatives thereof.
The oil control composition can inhibit the activity of 5-alpha reductase, thereby inhibiting the hyperfunction of sebaceous glands, inhibiting the excessive secretion of sebum, and keeping the skin in a healthy state, and has very good oil control effect and very high safety.
In the oil control active factor, the weight percentage of the azelaic acid amino acid derivative is 60-90%, and the weight percentage of the sum of the aspartic acid and the derivative thereof, the zinc pyrrolidone carboxylate, the caprylic acid and the derivative thereof is 10-40%; the weight ratio of the aspartic acid and the derivatives thereof to the zinc pyrrolidone carboxylate and the octanoic acid and the derivatives thereof is 1-5: 1. The reliability of the oil control activity factor is further improved, so that the oil control effect is further improved, and the reliability and the applicability of the oil control composition are further improved.
In the oil control active factor, the weight percentage of the azelaic acid amino acid derivative is 75-85%, and the weight percentage of the sum of the aspartic acid and the derivative thereof, the zinc pyrrolidone carboxylate, the caprylic acid and the derivative thereof is 15-25. Therefore, better oil control effect can be achieved, and the reliability and the applicability of the oil control composition are further improved.
The azelaic acid amino acid derivative is one of potassium azelate diglycinate, sodium azelate dilactanate, sodium azelate dillucinate and sodium azelate dilactanate. The azelaic acid amino acid derivative can enable the oil control active factor to have very good oil control performance, thereby being beneficial to further improving the reliability of the oil control composition. In the actual manufacturing process, potassium azelainate diglycine is mainly used as the azelaic acid amino acid derivative. This enables excellent oil control performance to be achieved.
The aspartic acid and the derivatives thereof are one or the combination of more than two of aspartic acid, sodium aspartate, magnesium aspartate, calcium aspartate, magnesium potassium aspartate, copper aspartate and zinc aspartate. The aspartic acid and the derivatives thereof can enable the oil control active factor to have very good oil control performance, thereby being beneficial to further improving the reliability of the oil control composition.
The caprylic acid and the derivatives thereof are one or the combination of more than two of caprylic acid, caprylyl glycine, caprylyl glutamic acid disodium, caprylyl salicylic acid and caprylyl silk amino acid. The octanoic acid and the derivative thereof can enable the oil control activity factor to have very good oil control performance, thereby being beneficial to further improving the reliability of the oil control composition.
The antiseptic is one or more of methyl hydroxybenzoate, ethylparaben, propyl hydroxybenzoate, phenoxyethanol, sodium benzoate, potassium sorbate, chlorphenesin, iodopropynyl butylcarbamate, polyaminopropyl biguanide, and bis (hydroxymethyl) imidazolidinyl urea. The preservatives are all cosmetic standard preservatives, and the use safety of the preservatives is high, so that the applicability of the oil control composition is improved.
In the actual manufacturing process, the preservative can be phenoxyethanol. It can play a very reliable anticorrosive effect, and the security is very high.
The thickener is one or more of xanthan gum, arabic gum, carrageenan, gellan gum, hydroxyethyl cellulose, hydroxypropyl methylcellulose and carbomer. The thickener has high reliability, so that a good thickening effect can be achieved, which is beneficial to further improving the applicability of the oil control composition.
In the actual manufacturing process, the following thickeners may be employed: the thickening agent is a combination of xanthan gum and hydroxyethyl cellulose, and the weight ratio of the xanthan gum to the hydroxyethyl cellulose is 2: 1. This results in a very good thickening effect, which contributes to further improving the applicability of the oil control composition.
The solvent is one or the combination of more than two of water, ethanol, glycerol, propylene glycol, methyl propylene glycol, butanediol, 1, 3-propylene glycol, dipropylene glycol, 1, 2-pentanediol and 1, 2-hexanediol. This enables the solvent to have a sufficiently high reliability, thereby contributing to further improvement in the reliability of the oil-overshoot control composition.
In the design and manufacture process, the solvent can adopt the following formula: the solvent is water, ethanol and 1, 2-pentanediol, the weight percentage of the ethanol in the solvent is 10-30%, the weight percentage of the 1, 2-pentanediol in the solvent is 1-5%, and the balance is water. This contributes to further improvement in reliability and applicability of the solvent. And the ethanol and the 1, 2-pentanediol in the solvent also have the function of assisting in bacteriostasis, so that the addition amount of the preservative can be reduced.
Experimental analysis:
table 1: experimental component group table
1. And (3) testing the inhibition rate of the activity of the 5-alpha reductase in vitro.
The inhibition rate of each component group against 5-alpha reductase was measured by HPLC (high performance liquid chromatography)
1.1 materials
1.1.1 major reagents
Absolute ethanol (analytically pure, Tianjin, Daloco chemical reagent works);
methanol (mao chemical plant, Tianjin);
Tris-HCl (pH5.5/6.8) (Nanjing Bega Biotech, Inc.);
PBS (shanghaiheifei biotechnology limited);
testosterone (T) (purity > 98%, BR);
reducing coenzyme II tetrasodium salt/beta-NADPH (purity 98%, Roche);
5-alpha reductase (extracted from rat epididymis).
1.1.2, main instruments
Model JJ324BC electronic balance (jieki shuangjie tester, ltd.);
DZF-6050 vacuum drying oven (Shanghai-Hengshi Co., Ltd.);
diamonsil Cig column (250 mm. times.4.6 mm,5 μm);
dean high performance liquid chromatograph (UVD170U detector, P680 pump, ASI-100 autosampler, TCC-1005 column oven).
1.2 methods
1.2.1, 5-alpha reductase Activity assay
Preparing a blank control group and each component group into a solution with the mass percentage of 10%, then adding 300 mu L of Tris-HCL buffer solution (PH 5.5), 500 mu L of enzyme extract (diluted), 50 mu L T, 50 mu L of sample (component group 1-6/blank control), 100 mu L of NADPH into a centrifuge tube in sequence, mixing the total reaction volume of 1000 mu L, reacting for 30min at 37 ℃, sampling for 0.5mL at 0min and 30min, adding 1mL of methanol to stop the reaction, vortexing for 1min, centrifuging for 15min at 5000rpm, taking supernatant, filtering by a 0.22 mu m microfiltration membrane, and detecting by HPLC.
Chromatographic conditions are as follows: diamonsil C18 column (250 mm. times.4.6 mm,5 μm), mobile phase methanol-water (70:30), flow rate 1.0mL/min, column temperature: room temperature, detection wavelength: 242nm, sample injection volume: 20 μ L.
And (3) HPLC determination: the detection is carried out according to the chromatographic conditions, and the changes of the T peak areas before (0min) and after (30min) the reaction of the trace reaction system are compared, so that the activity of the 5-alpha reductase in the enzymatic reaction system and the degree of the inhibition of each component group on the activity of the 5-alpha reductase are reflected.
5-alpha reductase Activity is expressed as T. mu. mol. L-1/(mg protein. multidot.30 min)
Percent T conversion [% of (0min T concentration measurement-30 min T concentration measurement)/0 min T concentration measurement [% of 100%
The inhibition ratio of alpha reductase activity%
The inhibition ratios of 5-alpha reductase activity of the respective component groups are shown in Table 2
Table 2: inhibition rate of 5-alpha reductase activity by component groups 1-6
In-vitro experimental data show that each component group has a good oil control effect, and the components 1 to 6 in the table 2 have high inhibition rates on the activity of 5-alpha reductase, wherein the component groups 3 and 4 have the inhibition rates of more than 70%.
2. Testing of oil control effect of human body
The component groups 1-6 and a blank control group are added into cosmetic auxiliary materials according to the mass percentage of 20 percent to be used as test samples.
The cosmetic auxiliary materials comprise, by mass, 10 parts of glycerol, 5 parts of 1, 3-butanediol, 0.1 part of sodium hyaluronate, 0.1 part of xanthan gum, 0.15 part of carbomer, 0.15 part of triethanolamine, 0.1 part of methylparaben, 0.4 part of phenoxyethanol and the balance of water.
The experimental principle is as follows: based on the principle of photometer, a special adhesive tape absorbs grease on human skin and then becomes a semitransparent adhesive tape, and the light transmittance of the semitransparent adhesive tape changes, so that the grease content on the skin surface is measured. The greater the transparency of the tape, the more oil is absorbed on the skin surface.
An experimental instrument: sebumeter SM815(CK, Germany)
Measuring parameters: sebum index T (μ g/cm2)
Subject: volunteers with oily skin (sebum index > 150. mu.g/cm 2), 105 persons per group of 15 persons, age 18-50 years.
The parameter testing method comprises the following steps: room temperature below 20 + -2 deg.C, Relative Humidity (RH) below 50 + -5%; the testees first cleaned their faces 1 hour before the test using the specified cleaning product, then entered the test environment to wait for one hour quietly, the tape was applied to the forehead of the volunteer and allowed to contact the skin for one minute, and then the frontal sebum index T was measured with SM 815.
The test method comprises the following steps: the test samples were applied to the face of volunteers 4 weeks daily, morning and evening, and the volunteers' initial sebum index (T0) was measured before starting the test and the corresponding sebum indices T7, T21, T28 were measured on days 7, 21, and 28 after starting the test, respectively.
Sebum suppression ratio r: r ═ 100% (T0-T)/T0%
Average sebum suppression ratio R: rn (Rn1+ Rn2+ Rn3+ … … + rnk)/k
The test results are shown in table 3:
table 3: average sebum suppression rate
According to in vitro test results, the cosmetics added with 20% of the components 1-6 have a good sebum secretion inhibiting effect and can play an oil control effect.
Subjective evaluation of volunteers
The volunteers who participated in the test were questionnaire on day 28.
Grading standard:
0-no improvement in skin condition, even more greasy
1-No improvement in skin oiliness, but no exacerbation
2-slight improvement in the degree of greasiness of the skin, but no apparent effect
3-improvement of the degree of greasiness of the skin
4-the degree of greasiness of the skin is obviously improved
The final score for each group was the weighted average of the volunteer scores for each group. The results are shown in Table 4:
table 4: subjective evaluation of volunteers
According to the subjective evaluation results of volunteers in Table 4, the cosmetics added with 20% of the components 1-6 show better oil control effect.
Example two:
one embodiment of the present invention is the use of the oil control composition in cosmetics. The oil-controlling composition is applied to the preparation of cosmetics, so that cosmetics having excellent oil-controlling effect can be obtained, and the applicability and safety of the application are excellent.
Example three:
the cosmetic comprises the oil control composition and cosmetic auxiliary materials, wherein the oil control composition is 1.0-30% by mass, and the cosmetic auxiliary materials are 70-99% by mass.
The oil control composition and the cosmetic auxiliary materials are combined into the cosmetic, so that the cosmetic has very good oil control performance, and the quality of the cosmetic is improved. The oil control composition and the cosmetic auxiliary materials are quite reasonable in proportion, the cosmetics are low in irritation, and can inhibit sebum secretion of sebaceous glands and prevent acnes and acnes. The cosmetic has the advantages of good oil control effect, high reliability, good safety, strong applicability and the like.
The cosmetic comprises lotion, essence, emulsion, cream, mask, gel or spray. The cosmetic can well meet the use requirements of people, and can ensure that the cosmetic has very high applicability.
Example four:
one embodiment of the present invention is a method for preparing the oil control composition, comprising the steps of:
(a) placing 80% of solvent in stirring equipment, adding the thickening agent into the solvent at a stirring speed of 1500 +/-500 revolutions per minute, stirring for 10-20 minutes, and then heating to 85 +/-5 ℃;
(b) uniformly mixing the preservative with the rest 20% of solvent, then adding the mixture into the mixed solution in the step (a), then adding the oil-controlling active factor into the mixed solution, and stirring for 15-20 minutes;
(c) and (c) cooling the mixed solution obtained in the step (b) to room temperature under the condition of keeping the stirring speed of 1500 +/-500 revolutions per minute, and filtering the mixed solution through 800-mesh filter cloth to obtain the oil control composition.
The preparation method is very simple, which can be operated and realized by workers conveniently, and can ensure that the preparation of the oil-controlling composition is very stable, the preparation method has very good preparation effect, the oil-controlling composition with very good quality can be obtained, and the reliability and the applicability of the preparation method are very good.
Example five:
a method of using the cosmetic of example three, comprising the steps of: after the facial skin is cleaned, the cosmetic is uniformly applied to the facial skin. The cosmetic composition according to the first embodiment can inhibit 5-alpha reductase activity, thereby inhibiting the hyperactivity of sebaceous glands, inhibiting the excessive secretion of sebum, and maintaining the skin in a healthy state, and has a very good oil control effect, thereby having a very good oil control effect on the facial skin.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The oil control composition is characterized by comprising the following components in percentage by weight: 1.0-20.0 parts of oil control active factor, 0.01-1.0 part of preservative, 0.1-2.0 parts of thickening agent and 77.0-98.89 parts of solvent; the oil control active factor is one or the combination of more than two of azelaic acid amino acid derivatives, aspartic acid and derivatives thereof, zinc pyrrolidone carboxylate, caprylic acid and derivatives thereof.
2. The oil control composition of claim 1, wherein: in the oil control active factor, the weight percentage of the azelaic acid amino acid derivative is 60-90%, and the weight percentage of the sum of the aspartic acid and the derivative thereof, the zinc pyrrolidone carboxylate, the caprylic acid and the derivative thereof is 10-40%; the weight ratio of the aspartic acid and the derivatives thereof to the zinc pyrrolidone carboxylate and the octanoic acid and the derivatives thereof is 1-5: 1.
3. The oil control composition of claim 2, wherein: in the oil control active factor, the weight percentage of the azelaic acid amino acid derivative is 75-85%, and the weight percentage of the sum of the aspartic acid and the derivative thereof, the zinc pyrrolidone carboxylate, the caprylic acid and the derivative thereof is 15-25.
4. The oil control composition of claim 1, wherein: the antiseptic is one or more of methyl hydroxybenzoate, ethylparaben, propyl hydroxybenzoate, phenoxyethanol, sodium benzoate, potassium sorbate, chlorphenesin, iodopropynyl butylcarbamate, polyaminopropyl biguanide, and bis (hydroxymethyl) imidazolidinyl urea.
5. The oil control composition of claim 1, wherein: the thickener is one or more of xanthan gum, arabic gum, carrageenan, gellan gum, hydroxyethyl cellulose, hydroxypropyl methylcellulose and carbomer.
6. The oil control composition of claim 1, wherein: the solvent is one or the combination of more than two of water, ethanol, glycerol, propylene glycol, methyl propylene glycol, butanediol, 1, 3-propylene glycol, dipropylene glycol, 1, 2-pentanediol and 1, 2-hexanediol.
7. Use of an oil control composition according to any one of claims 1 to 6 in the preparation of a cosmetic product.
8. A cosmetic characterized by: the oil control composition comprises the oil control composition and the cosmetic auxiliary material according to any one of claims 1 to 6, wherein the oil control composition is 1.0 to 30% by mass, and the cosmetic auxiliary material is 70 to 99% by mass.
9. The cosmetic according to claim 8, wherein: the cosmetic comprises lotion, essence, emulsion, cream, mask, gel or spray.
10. A method of making the oil control composition of any one of claims 1 to 6, characterized by comprising the steps of:
(a) placing 80% of solvent in stirring equipment, adding the thickening agent into the solvent at a stirring speed of 1500 +/-500 revolutions per minute, stirring for 10-20 minutes, and then heating to 85 +/-5 ℃;
(b) uniformly mixing the preservative with the rest 20% of solvent, then adding the mixture into the mixed solution in the step (a), then adding the oil-controlling active factor into the mixed solution, and stirring for 15-20 minutes;
(c) and (c) cooling the mixed solution obtained in the step (b) to room temperature under the condition of keeping the stirring speed of 1500 +/-500 revolutions per minute, and filtering the mixed solution through 800-mesh filter cloth to obtain the oil control composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210010537.0A CN114224766A (en) | 2022-01-06 | 2022-01-06 | Oil control composition, application of oil control composition in cosmetics, cosmetics and preparation method of oil control composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210010537.0A CN114224766A (en) | 2022-01-06 | 2022-01-06 | Oil control composition, application of oil control composition in cosmetics, cosmetics and preparation method of oil control composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114224766A true CN114224766A (en) | 2022-03-25 |
Family
ID=80745909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210010537.0A Pending CN114224766A (en) | 2022-01-06 | 2022-01-06 | Oil control composition, application of oil control composition in cosmetics, cosmetics and preparation method of oil control composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114224766A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080119527A1 (en) * | 2006-09-15 | 2008-05-22 | L'oreal | Composition for combating the localized hyperpigmentation of dark skin |
| CN110623883A (en) * | 2019-10-23 | 2019-12-31 | 广州那比昂生物科技有限公司 | Oil control composition and application thereof |
| CN111588671A (en) * | 2020-06-19 | 2020-08-28 | 广州科缇生物科技有限公司 | Composition with oil control and convergence effects, cosmetic and application of composition |
| CN113520948A (en) * | 2021-08-10 | 2021-10-22 | 东晟源研究院(广州)有限公司 | Balanced grease composition for inhibiting activity of 5 alpha-reductase and oil control gel thereof |
-
2022
- 2022-01-06 CN CN202210010537.0A patent/CN114224766A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080119527A1 (en) * | 2006-09-15 | 2008-05-22 | L'oreal | Composition for combating the localized hyperpigmentation of dark skin |
| CN110623883A (en) * | 2019-10-23 | 2019-12-31 | 广州那比昂生物科技有限公司 | Oil control composition and application thereof |
| CN111588671A (en) * | 2020-06-19 | 2020-08-28 | 广州科缇生物科技有限公司 | Composition with oil control and convergence effects, cosmetic and application of composition |
| CN113520948A (en) * | 2021-08-10 | 2021-10-22 | 东晟源研究院(广州)有限公司 | Balanced grease composition for inhibiting activity of 5 alpha-reductase and oil control gel thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0737199B1 (en) | Method for preparing concentrated biologically active silicon compounds | |
| JP3670279B2 (en) | Anti-acne composition containing polya cocos wolf fungus extract | |
| CN102946894A (en) | Method for preparing broussonetia kazinoki extract | |
| JPS63316711A (en) | Beautifying and whitening cosmetic | |
| CN114224766A (en) | Oil control composition, application of oil control composition in cosmetics, cosmetics and preparation method of oil control composition | |
| US4661519A (en) | Method for dermatological application | |
| US20060165630A1 (en) | Use of amide or ester of sugar and of fatty acid, for treating and/or preventing dry skin | |
| US20200215069A1 (en) | Melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promotor and wrinkle ameliorant | |
| CN113318018A (en) | Rose extract and extraction method and application thereof | |
| CN115887322B (en) | Whitening and freckle removing, skin smoothing and moisturizing essence and preparation method thereof | |
| CN115444766A (en) | Double-component shampoo with scalp nourishing effect and preparation method thereof | |
| JPH0656641A (en) | Cosmetic | |
| JPH1171234A (en) | Skin preparation for external use | |
| JPH06329516A (en) | Cosmetic | |
| JP2006347976A (en) | Dermal fibroblast activator | |
| JP4076477B2 (en) | Skin preparation | |
| JPH0977655A (en) | Skin preparation for external use | |
| FR2845596A1 (en) | Cosmetic or pharmaceutical skin care compositions, especially useful for combating dry skin, comprise amide or sugar mono- or polyester of linoleic acid as oxidation-stable linoleic acid source | |
| JPH01207225A (en) | Cosmetic for hair | |
| JPH1179934A (en) | Tyrosinase activity inhibiting composition, tyrosinase activity inhibitor, and bleaching solution and bath preparation using the same composition | |
| JP3869558B2 (en) | Skin external preparation suitable for whitening | |
| JP3869949B2 (en) | Skin external preparation suitable for whitening | |
| JP2003026532A (en) | Skin care preparation | |
| CN113233976B (en) | Gallic acid and aminoacetic acid eutectic and whitening cream containing eutectic | |
| JPH11236319A (en) | Composition for scalp and hair |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20220325 |
|
| WD01 | Invention patent application deemed withdrawn after publication |