JPH0977655A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin preparation for external use having excellent skin- beautifying and whitening action and safely applicable to the skin. SOLUTION: This preparation contains 0.005-20wt.% of 4-aminophenol as an active component. The preparation is further compounded with a liquid oil such as squalane or jojoba oil, a solid oil such as beeswax or cetyl alcohol, various activation agents, a humectant such as glycerol or 1,3-butylene glycol and various other agents and prepared in the form of lotion, cream, milky lotion, pack, etc. 4-Aminophenol has strong skin-beautifying and whitening effect compared with kojic acid, arbutin, etc., and is extremely useful as an active component of a skin preparation for external use.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a substance effective for whitening.

[0002]

2. Description of the Related Art Many substances having a whitening effect are already known. Commercialized products include kojic acid and arbutin. However, there were problems such as a weak effect.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to provide a skin external preparation which is safe when applied to the skin and has a large whitening effect.

[0004]

[Means for Solving the Problems] In order to solve the above-mentioned problems, the present inventors have screened and examined various substances and examined those which are useful as cosmetics. as a result,
When various experiments were conducted focusing on 4-aminophenol, it was found that the whitening effect was strong.

That is, it is an external preparation for skin containing 4-aminophenol.

This substance is used as a raw material for other cosmetics such as liquid oils such as squalane and jojoba oil, solid oils such as beeswax and cetyl alcohol, various activators, humectants such as glycerin and 1,3 butylene glycol and various chemicals. It can be added to prepare various external forms of the skin external preparation. For example, a lotion, a cream, a milky lotion, a pack, or the like may be used depending on the purpose. The blending amount varies depending on the formulation and use, but is usually 0.005 to 20%.

[0007]

EXAMPLE An example of an actual usage will be described below, but the present invention is not limited to this example.

Example-1 Lotion parts by weight Olive oil 0.5 4-Aminophenol 0.2 Polyoxyethylene (20E.0) sorbitan monostearate 2.0 Polyoxyethylene (60E.0) hydrogenated castor oil 2.0 Ethanol 10.0 1.0% sodium hyaluronate aqueous solution 5.0 Purified water 80.0

Example-2 Cream parts by weight A Squalane 20.0 Olive oil 2.0 Mink oil 1.0 Jojoba oil 5.0 Beeswax 5.0 Cetostearyl alcohol 2.0 Glycerin monostearate 1.0 Sorbitan monostearate 2.0 4-Aminophenol 0.1 B Purified water 47.9 Polyoxyethylene (20E.0) sorbitan monostearate 2.0 Polyoxyethylene (60E.0) hydrogenated castor oil 1.0 Glycerin 5.01 0.0% aqueous solution of sodium hyaluronate 5.0 Methyl paraoxybenzoate 0.1 Weigh A and B respectively, warm to 70 ° C, slowly add A to B with stirring, then slowly stir 30 Cooled to ° C.

Inhibition of tyrosinase activity (Test method) 0.9 ml of McClbaln buffer, 1.66 mM tyrosine (Tyrosin)
e) 1.0 ml of the solution, 0.1 ml of the sample dimethylsulfoxide solution, and 0.9 ml of purified water were placed in a screw vial and heated in a 37 ° C. constant temperature water bath for 5 minutes or more. Tyrosinase solution (manufactured by Sigma, mushroom-derived, 9
(14 units / ml), and the solution was kept warm in a constant temperature water bath at 37 ° C., and the absorbance was measured at 475 nm after 10 minutes. As a control, dimethylsulfoxide was added instead of the above sample solution, and the measurement was performed in the same manner. (Calculation formula) Tyrosinase activity inhibition rate (%) = {B- (AP)} /
B × 100 where A: Absorbance of sample specimen B: Absorbance of control P: Absorbance due to coloring of sample specimen (3 times dilution)

[0011]

[Table 1]

Use test Eight women's faces were divided into right and left sides, one of which was used as an example and the other of which was used as a comparative example once or more daily. Three months later, a questionnaire was given. In the comparative example, 4-aminophenol was replaced with water as compared with the examples. (Comparative Example 1,
2) The criteria are as follows, and the results of the questionnaire are summarized in the table below. Example is much better 3 Example is much better 2 Example is slightly better 1 No difference 0 Comparative example is slightly better -1 Comparative example is much better -2 Comparative example Is much better -3

[0013]

[0014]

[Effect] 4-Aminophenol has a stronger whitening effect than kojic acid and the like, and is very effective as an active ingredient of a skin external preparation.

Claims (1)

[Claims] 1. A skin external preparation containing 4-aminophenol