CN104707057B - A kind of composition with acne-removing and its preparation method and application - Google Patents
A kind of composition with acne-removing and its preparation method and application Download PDFInfo
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Abstract
The present invention relates to a kind of composition with acne-removing, is made of following parts by weight component：Purslane 15~40, cordate houttuynia 15~40, kaempferia galamga 10~35, Fructus Forsythiae 10~35, willow bark 10~35, peppermint 5~30, white fungus 5~30, Rhizoma Atractylodis Macrocephalae 4~28, snail mucus extract 0.1~10.Application of the composition with acne-removing in cosmetics, its additive amount are 0.5 20%.The beneficial effect of patent of the present invention is：Pharmaceutical formulation reasonable recipe, can be in multiple target spots, and many aspects play the effect of complete treatment whelk；Each component cooperates with mutually, has no toxic side effect, and has the double effects that take stopgap measures and effect a permanent cure, the curative effect person of showing.
Description
Technical field
The present invention relates to a kind of field of Chinese medicinal composition, is specially a kind of composition and its preparation side with acne-removing
Method and application.
Background technology
Whelk, nickname acne, acne, dark sore, the traditional Chinese medical science are also known as face sore, acne, are a kind of to betide pilosebaceous follicle
Chronic dermatosis.Its type is very much, and the cause of disease is various, is mainly in the portion that the sebaceous glands such as Head And Face, neck, shirtfront back enrich
Position.
The reason for doctor trained in Western medicine thinks, grows whelk is due to that internal 3male hormone secretion increases or increases relatively, so as to pierce
It is loose to swash hyperplasia of sebacous glands, secretion oil quantity rises, and blocks hair follicle, causes pathogenic bacterial infection, causes nonspecific inflammation anti-
Should.The medicine of western medical treatment whelk mainly has：(1) antibiotic such as tetracycline, minocycline, erythromycin, clindamycin；(2)
The amcinonides such as antisterone, ketone chaff azoles, Cimetidine, Norethisterone Compound, cimetidine；(3) sulphur, tretinoin, peroxidating
Other compounds such as benzene.But adrenal cortex function disorder, skin aging, flora alternating are easily caused using western medical treatment method
The side effects such as disease, mild nausea, slow poisoning.
Whelk is a kind of multifactor disease, its morbidity is mainly largely secreted with sex hormone level, sebaceous glands, acne third
Acidfast bacilli is bred, and the factor such as dyskeratosis and inflammation of pilosebaceous duct is related.Therefore, the design of a formula for dispelling pox should
It should consider following several factors：(1) select highly effective and safe antibacterial anti-inflammatory active ingredient, can kill rapidly propionibacterium acnes,
The skin parasitism flora such as acarid, prevent the etch of bacterium substance and the long acne of inflammation, while anti-inflammatory can be played the role of.(2) add suitable
When cutin inorganic agent and oil-control component, suppress fat secretion, dredge hair follicle, comprehensively accelerate horn cell metabolism, peel off epidermis
Thanatogenic tissue.(3) contain moisturizing active ingredient, prevent skin from becoming drying, skin is kept normal wetting state, promote to live
The release of property thing and Transdermal absorption, it is ensured that active ingredient quickly reaches lesions position.(4) add whitening and skin repair activity into
Point, the scar that whelk leaves is removed, impaired skin is repaired, eliminates lesion surface irregularity.
From the perspective of traditional Chinese medicine, mainly there are damp and hot lung heat blood-head, stomach, insufficiency of the spleen phlegm wet, the stasis of blood in the reason for causing acne
Blood blocks, and the deficiency of the kidney yin, feelings will do not save, affection of exogenous wind-heat, qi and blood stagnation and blood stasis phlegm knot etc..The Chinese medicine of anti-acne is mostly at present
The thermalization that disappears wet (such as radix scutellariae, the coptis), rush down scorching removing toxic substances (such as gypsum, cape jasmine), cooling and activating blood (such as dried rhizome of rehmannia, Radix Salviae Miltiorrhizae, the root bark of tree peony),
Removing toxicity for eliminating carbuncles suppurates (such as wild chrysanthemum, dandelion).
Application No. CN200310106513 Chinese invention patents disclose a kind of compound preparation for treating acne, by methyl sulfone
Mycin, chloroquine, Indomethacin form for major ingredient compounding.If the medicine long-time service, will have one to the skin of human body, liver and kidney
Fixed toxic action.Application No. CN200710014138 Chinese invention patent applications disclose the medicine for the treatment of acne, by criticizing
Leaf, rhizoma anemarrhenae, mast, chrysanthemum, dandelion, radix scrophulariae, Cortex Phellodendri, spina gleditsiae, Asian puccoon, Radix Salviae Miltiorrhizae and radix glycyrrhizae are made according to a certain weight ratio
Form.The Chinese invention patent of Application No. CN200710035784 discloses Pimple removing scream, included at least in prescription smilax,
5 kinds in coix seed, pueraria lobata, radix astragali, chrysanthemum, ophiopogon, ganoderma lucidum and giant knotweed component.Promulgated by the State Council in Application No. CN200710078403
Bright patent application disclose it is a kind of have anti-acne, add hole, the Chinese medicine composition of ecchymose removing, by weight form：10 parts of grass-leaved sweetflag, five
8 parts of taste, 1 part of Fructus Bruceae, 3 parts of cortex acanthopanacis, 2.5 parts of rheum officinale.Application No. CN200810145228 Chinese invention patent applications
A kind of medicine for treating acne is disclosed, kuh-seng, mast, the coptis, radix scutellariae, dandelion, folium isatidis, the day necessarily matched will be contained
Flower, frutus cnidii, oriental wormwood, rheum officinale, Cortex Phellodendri, Radix Salviae Miltiorrhizae, Fructus Forsythiae Chinese medicine, after crushed, are carried with alcohol reflux extraction and boiling respectively
Take, filtering and concentrating to dry, alcohol dried cream powder and water dried cream powder are finally sufficiently mixed to the final dry powder of obtained each taste bulk pharmaceutical chemicals.Application
Number a kind of compound acne-removing Chinese medical extract and preparation method thereof is disclosed for CN200910235809 Chinese invention patents, by pellet
Ginseng, cloves, radix scutellariae, rheum officinale magnolia obovata Chinese medicine composition, after being extracted by certain proportioning with absolute ethyl alcohol, filter, concentrate, sterilize
To finished product.Application No. CN201210439331 Chinese invention patents disclose a kind of pharmaceutical composition with acne-removing and
Its preparation method, by 25-35 parts of Radix Salviae Miltiorrhizae, non-irrigated 15-25 parts of lotus, 10-20 parts of the root of Dahurain angelica, 10-20 parts of rhizoma zingiberis, 5-15 parts of radix scutellariae, aloe
5-15 parts of medicinal material compositions, after alcohol extracting, filter, are concentrated to dryness to obtain finished product.Acne-removing composition preparation method disclosed above is opposite
It is extensive, it is mostly heating extraction, does not isolate and purify, there are product impurity is more, stability is poor, easily causes stimulate the reaction etc. to lack
Point.In addition above-mentioned formula is only the effect considered in terms of bactericidal antiphlogistic, and ignores and suppress fat secretion, dredging hair follicle, goes
Except acne scar, the factors such as sufferings symptom are eliminated, patient's recurrence or obstinate has been be easy to cause, has left acne scar, general effect is not
Can be satisfactory.
The content of the invention
The purpose of the present invention is in view of the deficienciess of the prior art, provide a kind of pure Chinese medicine, it is non-stimulated, without hormone, nothing
Antibiotic, be not easy to rebound, the composition with acne-removing curative for effect.It can be used to prevent and treat whelk, its effect
Substantially, effect is fast, removes acne scar, eliminates lesion surface irregularity, and have tender skin and moisturizing white-skinned face function concurrently.
Another object of the present invention is to provide a kind of preparation method of the composition with acne-removing.
The third object of the present invention is to provide a kind of application of the composition with acne-removing.
To achieve these goals, the technical solution adopted by the present invention is：A kind of composition with acne-removing, by with
Lower parts by weight component is made：Purslane 15~40, cordate houttuynia 15~40, kaempferia galamga 10~35, Fructus Forsythiae 10~35, willow bark 10~
35th, peppermint 5~30, white fungus 5~30, Rhizoma Atractylodis Macrocephalae 4~28, snail mucus extract 0.1~10.
Preferably, the composition with acne-removing, is made of following parts by weight component：Purslane 20~30,
Cordate houttuynia 20~30, kaempferia galamga 15~30, Fructus Forsythiae 15~30, willow bark 15~30, peppermint 10~20, white fungus 10~20, Rhizoma Atractylodis Macrocephalae 10
~20, snail mucus extract 0.5~6.
A kind of the step of preparation method of the composition with acne-removing, it includes, is as follows：
(1), pretreatment of raw material：Respectively by purslane, cordate houttuynia, kaempferia galamga, Fructus Forsythiae, willow bark, peppermint, white fungus and Rhizoma Atractylodis Macrocephalae powder
It is broken into powdered, is then uniformly mixed, obtains traditional Chinese medicinal material raw materials mixture；
(2), extract and filter：Traditional Chinese medicinal material raw materials mixture is added to the water or C1~C3 lower alcohols of 3~30 times of its weight
Solvent, is extracted 1~3 time under the conditions of 10-100 DEG C, and each extraction time is from 0.5~4h；Then the used filter of material will be extracted,
Or centrifuge, or the mode of squeezing collects clear filtrate.
(3), micro-filtration：Snail mucus extract is added into above-mentioned clear filtrate, after mixing, with retention aperture 0.1
~1um micro-filtrate membrane filtrations, obtain micro-filtrate.
(4), ultrafiltration：Micro-filtrate carries out ultrafiltration with the ultrafiltration membrane of 5000~30000Da of molecular cut off (dalton), obtains
Ultrafiltrate.
(5), nanofiltration：Ultrafiltrate carries out nanofiltration with the NF membrane of 80~300Da of molecular cut off, obtain nanofiltration liquid.
(6), concentrate：Nanofiltration liquid is concentrated, obtains concentrate or thick paste, or thick paste is dried to solid powder.
Wherein, C1~C3 lower alcohol solvents can be methanol and ethanol.
Application of the composition with acne-removing in cosmetics, its additive amount are 0.5-20%.
Preferably, additive amount of the composition with acne-removing in cosmetics is 1-10%.
The composition with acne-removing its applicable formulation can be solution, lotion, paste, suspension, spraying,
Gel, facial mask, shampoo and facial cleanser etc..
The beneficial effect of patent of the present invention is：Pharmaceutical formulation reasonable recipe, can be in multiple target spots, and many aspects play comprehensively
Treat the effect of whelk；Wherein, purslane and cordate houttuynia have bactericidal anti-inflammatory effect, and kaempferia galamga has the function that to dredge hair follicle,
Fructus Forsythiae can suppress sebum secretion, and salicis,cortex can remove the cuticula of old accumulation in pore, and peppermint can eliminate whelk and bring
Pain, symptom of itching, white fungus can keep the normal oil-water balance of skin, and Rhizoma Atractylodis Macrocephalae can play the role of eliminating whelk scar, snail
Mucus extract has effects that to repair skin injury, eliminates lesion surface irregularity etc.；Each component cooperates with mutually, nothing
Toxic side effect, has the double effects that take stopgap measures and effect a permanent cure, the curative effect person of showing.
Specific embodiment
With reference to embodiment, the present invention is described in further detail, but the implementation of the present invention is not limited to this.
Principle explanation
Purslane：For Portulacaceae annual herb plant.It is sour, cold, nontoxic, there are clearing heat and promoting diuresis, removing toxicity for detumescence, disappear
Inflammation, quench the thirst, the effect of diuresis.《Compendium of Materia Medica》Furuncle swelling toxin, for many years malignant sore can be treated by recording purslane external application.Modern pharmacology
Research shows that its active ingredient purslane acid amides, Baptitoxine, lupeol, suberone, norepinephrine, sylvite are to Cuo
Sore Propionibacterium, staphylococcus aureus etc. have stronger inhibitory action, it plays anti-inflammatory and antibacterial effect in this formula.
Cordate houttuynia：The dry aerial parts of saururaceae plant houttuynia cordata.Acrid flavour, it is cold, it is distributed in lung channel, there is heat-clearing solution
The effect of sore etc. is treated in poison, detumescence.Modern pharmacology experiment shows, the main active decanoy acetaldehyde of cordate houttuynia, lauryl aldehyde,
Methyln nonyl ketone, cloves alkene etc. have the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.Pass through the association with purslane
With antibacterial, there is good suppression to make to propionibacterium acnes, staphylococcus aureus, staphylococcus albus and Escherichia coli
With.
Kaempferia galamga：It is volatile oil and Kaempferol, Kaempferide, flavonoids, tonka-bean for the root-like stock of Zingiber kaempferia galanga platymiscium kaempferia galanga
Smart class etc..Treat whelk the effect of in terms of effect, except there is different degrees of suppression to make to 10 kinds of common causative fungies
With the medicine also has the effect of dredging pore, accelerating unnecessary sebum and Toxic Metabolites to excrete.
Fructus Forsythiae：For the fruit of Oleaceae plants Fructus Forsythiae, bitter, cold nature, containing forsythol, sterol compound, saponin and
Flavonoids, horse tongue resinol glucoside isoreactivity component, they have smegma certain inhibitory action, it is possible to reduce skin
The effect of skin excess oiliness, improvement Oily skin quality.Simultaneously as Fructus Forsythiae antimicrobial spectrum is very wide, there is obvious anti-inflammatory effect, can
Promote the formation of inflammatory barrier, reduce capillary permeability, reduce inflammatory and ooze out, it is local red and swollen caused by elimination whelk,
Reduce the generation of whelk and epifolliculitis.
Salicis,cortex：It is the cortical section of deciduous tree white willow, its principle active component is salicoside, adsorbs and receives through human body
Turn to be hydrolyzed into salicylic acid.Salicylic acid can penetrate into the deep layer of pore, act on hair follicle parietal cell, dissolve old accumulation in pore
Cuticula, improves the situation of pore obstruction, therefore the pore that the formation of acne and diminution can be blocked to be stretched.Salicis,cortex is originally being matched somebody with somebody
Play the role of removing cutin in side, promote skin metabolism, peel off epidermis etc., have the function that to accelerate to cure whelk.
Peppermint：For the herb or leaf of labiate peppermint or family peppermint, contain menthol, menthones, isomenthone, thin
The Multiple components such as lotus brain, peppermint esters,《Compendium of Materia Medica》Recording peppermint has " all diseases of throat, ability to speak.Control scrofula, sore scabies, wind
The effect of scabies urticaria ".Peppermint plays in this formula stimulates cutaneous nerve tip receptor, produces cool sensation, and suppress the pain sensation
Nerve, so that releive shouting pain caused by whelk and pruritis.
White fungus：Mucopolysaccharide body containing components such as abundant glucose, trehalose, polyacid pentose and mannitols, such thing
Matter structure is very similar with sodium hyaluronate, and moisturizing power is splendid, is good natural moisture preserving component.Since dry skin is to cause human body
The main reason for growing whelk, which plays the moisture-keeping function of skin in formula, by controlling the oil-water balance of skin,
Skin is set to be maintained at normal moisture state.Furthermore it is also possible to promote the discharge of sebum, promote the osmotic absorption of medicine.
Rhizoma Atractylodis Macrocephalae：Belong to composite family herbaceos perennial, it is warm-natured, it is sweet in flavor, bitter, there is the effect of anti-aging.Ancient books《Haigoushen》
Rhizoma Atractylodis Macrocephalae is referred to as：" interarea light is pleased, nti-freckle of preserving youthful looks ", since it contains atractylone, atractylol, atractylodes lactone, soluble polysaccharide, amino
Acid, flavone compound, have the function that whitening spot-removing, anti-oxidant and effect slow down aging.Played in this formula and eliminate the youth
The effect of acne scar.
Snail mucus extract：Contain collagen, elastin, chondroitin sulfate, allantois in snail mucus extract
Element, glycolic, natural antibacterial peptide, vitamin, calcium, iron, copper, phosphorus, etc. the nutriment wanted of a variety of needed by human body.In this formula
It has the work(for repairing skin injury, promoting wound healing, stimulate cytothesis, eliminating lesion surface irregularity etc.
Effect.
The above-mentioned various pharmaceutical formulation reasonable recipes of the present invention, can be in multiple target spots, and many aspects play the complete treatment youth
The effect of acne.Wherein, purslane and cordate houttuynia have a bactericidal anti-inflammatory effect, and kaempferia galamga has the function that to dredge hair follicle, and Fructus Forsythiae can be with
Suppress sebum secretion, salicis,cortex can remove the cuticula of old accumulation in pore, and peppermint can eliminate pain, the disease of itching that whelk is brought
Shape, white fungus can keep the normal oil-water balance of skin, and Rhizoma Atractylodis Macrocephalae can play the role of eliminating whelk scar, snail mucus extract
Have effects that to repair skin injury, eliminate lesion surface irregularity etc..Each component cooperates with mutually, has no toxic side effect,
With the double effects that take stopgap measures and effect a permanent cure, the curative effect person of showing.
Embodiment 1
A kind of composition with acne-removing, is made of following parts by weight component：Purslane 16, cordate houttuynia 16, mountain
How 11, Fructus Forsythiae 11, willow bark 11, peppermint 6, white fungus 6, Rhizoma Atractylodis Macrocephalae 5, snail mucus extract 0.3.
Embodiment 2
A kind of composition with acne-removing, is made of following parts by weight component：Purslane 39, cordate houttuynia 39, mountain
How 34, Fructus Forsythiae 34, willow bark 34, peppermint 29, white fungus 29, Rhizoma Atractylodis Macrocephalae 27, snail mucus extract 9.
Embodiment 3
A kind of composition with acne-removing, is made of following parts by weight component：Purslane 20~30, cordate houttuynia 20
~30, kaempferia galamga 15~30, Fructus Forsythiae 15~30, willow bark 15~30, peppermint 10~20, white fungus 10~20, Rhizoma Atractylodis Macrocephalae 10~20, snail
Mucus extract 0.5~6.
Embodiment 4
A kind of composition with acne-removing, is made of following parts by weight component：Purslane 21, cordate houttuynia 20, mountain
How 16, Fructus Forsythiae 16, willow bark 16, peppermint 16, white fungus 11, Rhizoma Atractylodis Macrocephalae 11, snail mucus extract 1.
Embodiment 5
A kind of composition with acne-removing, is made of following parts by weight component：Purslane 30, cordate houttuynia 16, mountain
How 11, Fructus Forsythiae 11, willow bark 13, peppermint 8, white fungus 9, Rhizoma Atractylodis Macrocephalae 6, snail mucus extract 0.8.
The step of preparation method of the above-mentioned composition with acne-removing, it includes, is as follows：
(1), pretreatment of raw material：Respectively by purslane, cordate houttuynia, kaempferia galamga, Fructus Forsythiae, willow bark, peppermint, white fungus and Rhizoma Atractylodis Macrocephalae
Medicinal material, which is chosen, to be picked up, and is removed impurity, is ground into powdered；Then it is uniformly mixed according to the above ratio, obtains traditional Chinese medicinal material raw materials mixture；Will
Above-mentioned medicine Chinese medicine is respectively crushed into 30-70 mesh；Preferably, above-mentioned medicine Chinese medicine is respectively crushed into 50 mesh.
(2), extract and filter：Above-mentioned traditional Chinese medicinal material raw materials mixture is thrown into extractor, adds 5~20 times of its weight
Water or C1~C3 lower alcohol solvents, extracted 1~3 time under the conditions of room temperature (10-30 DEG C) or 31-100 DEG C, each extraction
Time is from 1~3h；Then the used filter of material, or centrifugation will be extracted, or the mode of squeezing collects clear filtrate.It is preferred that use 3-foot
Centrifuge is centrifuged, and rotating speed is 2500-4500 revolutions per seconds, collects clear filtrate.
(3), micro-filtration：Snail mucus extract is added into above-mentioned clear filtrate, after mixing, with retention aperture 0.1
~1um microfiltration membranes remove the impurity such as the thalline of major diameter, suspended solid, obtain micro-filtrate.
(4), ultrafiltration：Micro-filtrate is subjected to ultrafiltration with the ultrafiltration membrane of 8000~20000Da of molecular cut off, removes macromolecular
The impurity such as pigment, tannin, obtain ultrafiltrate；Preferably, the ultrafiltration membrane of molecular cut off 10000Da is selected to carry out ultrafiltration
(5), nanofiltration：Ultrafiltrate is subjected to nanofiltration with the NF membrane of 100~200Da of molecular cut off, remove water or C1~
C3 lower alcohol solvents, obtain nanofiltration liquid；Preferably, ultrafiltrate is subjected to nanofiltration with the NF membrane of 150~Da of molecular cut off.
(6), concentrate：Nanofiltration liquid is concentrated, obtains concentrate or thick paste, or thick paste is dried to solid powder.
The snail mucus extract, wherein containing chondroitin sulfate 0.1~5%, allantoin 0.1~5%, collagen
0.1~10%, the molecular weight distribution of micromolecule polypeptide is very suitable for human skin absorption, adds in 3000~5500 dalton
It is added in cosmetics and is conducive to repair impaired skin, promote healing, accelerates cytothesis.The snail mucus extract is from white
In beautiful snail mucus made from extraction, collagen, allantoin, chondroitin sulfate, micromolecule polypeptide active ingredient are mainly contained.
The preparation method of the snail mucus extract, it comprises the following steps：
(1) extract：Snail mucus is taken, adds the water of 5~30 times of its quality, is pressed in 5~60 DEG C of temperature and 40~100Mpa
High-pressure homogenization historrhexis is carried out under power to extract 1~3 time.
(2) centrifuge：High-pressure homogenization material obtained by (1) step is separated with centrifuge, collects clear liquid.
(3) micro-filtration：Clear liquid aperture is 0.1 μm -0.5 μm of microfiltration of ceramic membrane, except degerm, the impurity such as microorganism；
(4) ultrafiltration：Micro-filtration dialyzate molecular cut off is the ultrafiltration membrane ultrafiltration of 6,000~50,000 dalton, is removed
The human skins such as the albumen of macromolecular, polysaccharide are difficult to the material absorbed；
(5) nanofiltration：Ultrafiltration dialysis liquid is concentrated with the NF membrane of 80~2,000 dalton of molecular cut off, collects concentrate,
Snail mucus extract is obtained, the snail mucus extract used for cosmetics is concentrated to give by nanofiltration.The snail mucus
It is preferred that the mucus that white jade snail produces.
Embodiment 6
A kind of composition with acne-removing, weighs purslane 250g, cordate houttuynia 200g, kaempferia galamga 120g, Fructus Forsythiae respectively
120g, willow bark 110g, peppermint 70g, white fungus 70g, Rhizoma Atractylodis Macrocephalae 50g.It is uniformly mixed after each traditional Chinese medicine powder is broken into powder, then will
It is placed in extractor, adds the drinking water of 25kg, and in stirring extraction 3 times under room temperature, each extraction time is 1h, is carried
The filtered processing of material is taken to collect clear filtrate.
The snail mucus extract of 10g is added into above-mentioned clear filtrate, it is after mixing, micro- with retention aperture 0.5um
Filter membrane removes the impurity such as the thalline of major diameter, suspended solid, obtains the ultrafiltration membrane that micro-filtrate uses molecular cut off 10000Da respectively
Ultrafiltration is carried out, the NF membrane of molecular cut off 200Da carries out nanofiltration.Nanofiltration concentrate is concentrated into 3000g with evaporator, is had
There is the composition extracting solution of acne-removing.
Embodiment 7
A kind of composition with acne-removing, weighs purslane 350g, cordate houttuynia 200g, kaempferia galamga 100g, Fructus Forsythiae respectively
100g, willow bark 100g, peppermint 50g, white fungus 50g, Rhizoma Atractylodis Macrocephalae 45g.It is uniformly mixed after each traditional Chinese medicine powder is broken into powder, then will
It is placed in extractor, adds the drinking water of 28kg, and in stirring extraction 2 times under room temperature, each extraction time is 1.5h,
Extract the filtered processing of material and collect clear filtrate.
The snail mucus extract of 10g is added into above-mentioned clear filtrate, it is after mixing, micro- with retention aperture 0.5u m
Filter membrane removes the impurity such as the thalline of major diameter, suspended solid, obtains the ultrafiltration membrane that micro-filtrate uses molecular cut off 10000Da respectively
Ultrafiltration is carried out, the NF membrane of molecular cut off 200Da carries out nanofiltration.Nanofiltration concentrate spray drying treatment, obtains having and dispels
The composition powder 206g of acne effect.
Embodiment 8
A kind of composition with acne-removing, weighs purslane 200g, cordate houttuynia 200g, kaempferia galamga 100g, Fructus Forsythiae respectively
100g, willow bark 100g, peppermint 100g, white fungus 100g, Rhizoma Atractylodis Macrocephalae 80g.It is uniformly mixed after each traditional Chinese medicine powder is broken into powder, then
It is placed in extractor, adds the drinking water of 28kg, in stirring extraction 3 times under room temperature, each extraction time is 1h,
Extract the filtered processing of material and collect clear filtrate.
The snail mucus extract of 10g is added into above-mentioned clear filtrate, it is after mixing, micro- with retention aperture 0.2um
Filter membrane removes the impurity such as the thalline of major diameter, suspended solid, obtains the ultrafiltration membrane that micro-filtrate uses molecular cut off 6000Da respectively
Ultrafiltration is carried out, the NF membrane of molecular cut off 200Da carries out nanofiltration.Nanofiltration concentrate is concentrated into 400g with evaporator, is had
There is the composition thick paste of acne-removing.
Embodiment 9
A kind of oil control and acne removal toner, has following mass percent component to be made,
Preparation method is as follows：Stir while by EDTA-Na2, glycerine, butanediol and pure water put into agitated kettle one by one
In, it is then heated to about 85~90 DEG C of system temperature；2., stand insulation 20 minutes with sterilizing, then while stirring slowly cool down
To 60 DEG C or so, by amino acid humectant input system；When continuing stirring and being cooled to 40 DEG C or so, will with acne-removing
Composition and methylisothiazolinone respectively in input system, and continue stir about 10 minutes, stop stirring, cooling, then
Censorship is waited to discharge.Preferably, the composition with acne-removing selects the combination with acne-removing made from embodiment 6
Thing, the composition with acne-removing that other embodiment obtains is with same effect.
Clinical trial is as follows, randomly selects the whelk patient 100 of 15-35 Sui, its average age is 24 years old, wherein man
Property 73, women 27.Twice daily, affected part is smeared, is treated one month altogether.
Embodiment 10
A kind of oil control and acne removal mildy wash, has following mass percent component to be made,
Clinical trial is as follows, randomly selects the whelk patient 100 of 15-35 Sui, its average age is 23 years old, wherein man
Property 70, women 30.Twice daily, affected part is smeared, is treated one month altogether.
Embodiment 11
A kind of oil control and acne removal facial mask, it includes following parts by weight component：
The preparation method of above-mentioned oil control and acne removal facial mask：Composition with acne-removing, carboxymethyl cellulose are added to
In deionized water, vitamin E, vegetable oil, hydrogenation cocoa butter and emulsifying agent emulsifying are stirring evenly and then adding into, then adds mountain
Pears alcohol and glycerine and preservative for auxiliary and essence etc., stir evenly.Wherein, the vegetable oil can be selected greatly
Soya-bean oil, emulsifying agent can be polysorbas20 or Tween 80.
Clinical trial is as follows, randomly selects the whelk patient 100 of 15-35 Sui, its average age is 23 years old, wherein man
Property 70, women 30.Twice daily, affected part is smeared, is treated one month altogether.
Clinical test
1st, disease is classified：
(1) it is slight (I grades)：Show as based on acne, a small amount of papule and warts, total lesion number is less than 30；
(2) moderate (II grades)：Acne are shown as, the papule and warts of moderate, between total lesion number 31~50；
(3) moderate (III level)：Show as a large amount of papules and warts, accidental big cutaneous inflammatory lesion, widely distributed, total lesion
For number between 51~100, tubercle is less than 3；
(4) severe (IV grades)：Tubercle/cystic acne or acne conglobata are shown as, majority has pain and forms tumour
And sinus, total lesion number is more than 100, and tubercle/tumour is more than 3.
2nd, efficacy assessment standard and treatment results：
Recovery from illness：Acne scar acne print disappears, skin smooth finish, is discontinued 3 months without recurrence；
Effectively：Total skin lesion number significantly reduces；
It is invalid：Clinical symptoms are without significant change, and total skin lesion number is without reduction.
3rd, therapeutic effect
The treatment results of embodiment 11
The treatment results of embodiment 5
Other embodiment obtains the composition with acne-removing with type effect.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention and from above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification,
Equivalent replacement mode is should be, is included within protection scope of the present invention.
Claims (6)
- A kind of 1. composition with acne-removing, it is characterised in that：It is made of following parts by weight component：Purslane 15~ 40th, cordate houttuynia 15~40, kaempferia galamga 10~35, Fructus Forsythiae 10~35, willow bark 10~35, peppermint 5~30, white fungus 5~30, Rhizoma Atractylodis Macrocephalae 4 ~28, snail mucus extract 0.1~10；Contain chondroitin sulfate 0.1~5%, allantoin in the snail mucus extract 0.1~5%, collagen 0.1~10%, the molecular weight distribution of micromolecule polypeptide is in 3000~5500 dalton.
- A kind of 2. composition with acne-removing according to claim 1, it is characterised in that：By following parts by weight array Divide and be made：Purslane 20~30, cordate houttuynia 20~30, kaempferia galamga 15~30, Fructus Forsythiae 15~30, willow bark 15~30, peppermint 10~ 20th, white fungus 10~20, Rhizoma Atractylodis Macrocephalae 10~20, snail mucus extract 0.5~6.
- A kind of 3. preparation method of composition with acne-removing according to claims 1 or 2, it is characterised in that： The step of it includes is as follows：(1), pretreatment of raw material：Purslane, cordate houttuynia, kaempferia galamga, Fructus Forsythiae, willow bark, peppermint, white fungus and Rhizoma Atractylodis Macrocephalae are ground into respectively It is powdered, then it is uniformly mixed, obtains traditional Chinese medicinal material raw materials mixture；(2), extract and filter：Traditional Chinese medicinal material raw materials mixture is added to the water or C1~C3 lower alcohol solvents of 3~30 times of its weight, Extracted 1~3 time under the conditions of 10-100 DEG C, each extraction time is from 0.5~4h；Then filter, collect clear filtrate；(3), micro-filtration：Snail mucus extract is added into above-mentioned clear filtrate, after mixing, with retention 0.1~1um of aperture Micro-filtrate membrane filtration, obtains micro-filtrate；(4), ultrafiltration：Micro-filtrate carries out ultrafiltration with the ultrafiltration membrane of 5000~30000Da of molecular cut off, obtains ultrafiltrate；(5), nanofiltration：Ultrafiltrate carries out nanofiltration with the NF membrane of 80~300Da of molecular cut off, obtains nanofiltration liquid.
- A kind of 4. preparation method of composition with acne-removing according to claim 3, it is characterised in that：The C1 ~C3 lower alcohol solvents are methanol and ethanol.
- 5. a kind of application of the composition with acne-removing according to claim 3 in cosmetics, its additive amount are 0.5-20%.
- 6. a kind of application of the composition with acne-removing according to claim 3 in cosmetics, its additive amount are 1-10%.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108294992A (en) * | 2018-03-31 | 2018-07-20 | 佛山文森特知识产权服务有限公司 | A kind of acne-removing composition |
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| MX2022008844A (en) * | 2020-01-17 | 2022-08-10 | Unilever Ip Holdings B V | Topical composition comprising hydroxamic acid and atractylenolide. |
| CN111110619B (en) * | 2020-02-14 | 2022-06-28 | 广州市科能化妆品科研有限公司 | Oil-control acne-removing composition and application thereof in cosmetics |
| CN112006961A (en) * | 2020-09-17 | 2020-12-01 | 怀化学院 | Preparation method of acne-removing traditional Chinese medicine mask essence and acne-removing traditional Chinese medicine mask |
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| CN101181221A (en) * | 2007-11-28 | 2008-05-21 | 广州壹鹏电器科技有限公司 | Snail glue cosmetics |
| CN102793665A (en) * | 2011-05-26 | 2012-11-28 | 河南羚锐制药股份有限公司北京药物研究院 | Flexible nanoliposomes with procyanidine and preparation method for flexible nanoliposomes |
| CN104188894A (en) * | 2014-08-11 | 2014-12-10 | 吉林大学 | Butenafine temperature-sensitive gel preparation and preparation method thereof |
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| CN101181221A (en) * | 2007-11-28 | 2008-05-21 | 广州壹鹏电器科技有限公司 | Snail glue cosmetics |
| CN102793665A (en) * | 2011-05-26 | 2012-11-28 | 河南羚锐制药股份有限公司北京药物研究院 | Flexible nanoliposomes with procyanidine and preparation method for flexible nanoliposomes |
| CN104188894A (en) * | 2014-08-11 | 2014-12-10 | 吉林大学 | Butenafine temperature-sensitive gel preparation and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108294992A (en) * | 2018-03-31 | 2018-07-20 | 佛山文森特知识产权服务有限公司 | A kind of acne-removing composition |
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