CN102138994A - Pharmaceutical composition for preventing and treating black gill disease of aquatic animals - Google Patents
Pharmaceutical composition for preventing and treating black gill disease of aquatic animals Download PDFInfo
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Abstract
The invention relates to a pharmaceutical composition for preventing and treating the black gill disease of aquatic animals. The pharmaceutical composition is prepared from the following components in parts by weight: 50 parts of cortex dictamni, 75 parts of common cnidium fruit, 50 parts of golden larch bark, 40 parts of artemisia leaves, 45 parts of sophora flavescens, 45 parts of fineleaf schizonepeta herb, 25 parts of ephedra, 30 parts of common threewingnut root and 25 parts of gypsum rubrum. In the invention, the synergy of all the components is exerted through selecting and reasonably proportioning the pharmaceutical compositions, bacterial growth and reproduction are inhibited through interfering the protein synthesis and the folate metabolism of sensitive pathogenic microorganisms, and the pharmaceutical composition can be used for preventing and treating symptoms of aquatic animals caused by various bacteria and fungi, such as black gills, yellow gills, gill rotting, brown spots, tail rotting, body rotting, and the like. The invention is applied to remarkably improving the water quality, obviously adding the feed quantity and obviously reducing unintelligible death; and the special natural biological active substances in the pharmaceutical composition can control the metabolism of organisms and help the aquatic animals recover. Meanwhile, the pharmaceutical composition provided by the invention is a pure Chinese medicine preparation without any toxic and side effects and ca not form pharmaceutical residue in the aquatic animals.
Description
Technical field
The present invention relates to a kind of aquatic animal medication, relate in particular to a kind of pharmaceutical composition of preventing and treating aquatic animal black gill disease disease.
Background technology
The black gill disease disease is a common disease in fish, shrimp, the Eriocheir sinensis breeding process, also is accompanied by multiple symptoms such as the yellow gill, gill rot, brown patch, mashed tail, mashed body occur simultaneously, has more present breed middle and late stage.Wherein ill shrimp body gill portion stops up or is rotten to the corn, directly influences the normal function of gill filament tissue, and the oxygen exchange amount is obstructed.In addition, sick shrimp can occur also that appendage is rubescent, tail fan is dark green, and it is dull to take action, and brings out other diseases even causes death when serious.
Its body colour blackout during the Fish morbidity, especially with head for very, move about slowly dyspnea, mucus increases on the gill, gill filament swelling, gill filament end is damaged when serious, and cartilage exposes, the gill cover has transparent speckle or perforation, be blank, reason of this sick morbidity is due to the injured secondary infection of the fish gill, main harm grass, green grass or young crops, Cyprinus carpio, crucian carp, mandarin fish etc.
The main diseases that causes the black gill disease disease is because of having: 1. bottom material of pond for breeding worsens, the bed mud blackening is smelly, and debirs such as remaining feedstuff, aquatic animal feces, biological corpse gather too much in the water, cause the water body muddiness, the transparency reduction, and the aquatic animal living environment is abominable.2. in the breeding water body, noxious substance content overproofs such as heavy metal ion, nitrite, ammoniacal nitrogen.3. many kinds of reasons cause the mortality of algae in the breeding water body, cause bottom material of pond for breeding and water quality to be polluted.
Summary of the invention
The present invention mainly solves tradition and prevents and treats the medicine of symptoms such as aquatic animal black gill disease, the yellow gill, gill rot, brown patch, mashed tail, mashed body and cure the symptoms, not the disease, and effect is not satisfactory, and technical problem such as residual poison of drug in the animal body of treatment back.
For solving the problems of the technologies described above, the technical solution used in the present invention is: the pharmaceutical composition of preventing and treating aquatic animal black gill disease disease is made by the following components in part by weight proportioning: 5 parts～70 parts of Cortex Dictamni, 20 parts～160 parts of Fructus Cnidiis, 10 parts～100 parts of Cortex Pseudolariciss, 10 parts～90 parts of Folium Artemisiae Argyis, 10 parts～100 parts of Radix Sophorae Flavescentiss, 10 parts～100 parts of Herba Schizonepetae, 5 parts～50 parts in Herba Ephedrae, 10 parts～70 parts of Radix Tripterygii Wilfordiis, 10 parts～60 parts of Mirabilitum crystallinas.
The optimum ratio of said components is: 20 parts～70 parts of Cortex Dictamni, 35 parts～120 parts of Fructus Cnidiis, 30 parts～80 parts of Cortex Pseudolariciss, 30 parts～75 parts of Folium Artemisiae Argyis, 40 parts～90 parts of Radix Sophorae Flavescentiss, 35 parts～85 parts of Herba Schizonepetae, 20 parts～40 parts in Herba Ephedrae, 20 parts～55 parts of Radix Tripterygii Wilfordiis, 20 parts～45 parts of Mirabilitum crystallinas.
The optimal components ratio of said components is: 50 parts of Cortex Dictamni, 75 parts of Fructus Cnidiis, 50 parts of Cortex Pseudolariciss, 40 parts of Folium Artemisiae Argyis, 45 parts of Radix Sophorae Flavescentiss, 45 parts of Herba Schizonepetae, 25 parts in Herba Ephedrae, 30 parts of Radix Tripterygii Wilfordiis, 25 parts of Mirabilitum crystallinas.
The preparation aforementioned pharmaceutical compositions can adopt following method, and this method may further comprise the steps: a. crosses Cortex Dictamni, Fructus Cnidii, Cortex Pseudolaricis, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Herba Schizonepetae, Herba Ephedrae, Radix Tripterygii Wilfordii, Mirabilitum crystallina pulverize separately 120 eye mesh screens and obtains drug powder; B. the powder of Cortex Dictamni, Fructus Cnidii, Cortex Pseudolaricis, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Herba Schizonepetae, Herba Ephedrae, Radix Tripterygii Wilfordii, Mirabilitum crystallina is put into the baking oven inner drying respectively, 80 ℃ of bake out temperatures, dry 30 minutes; C. dried Cortex Dictamni powder, Fructus Cnidii powder, Cortex Pseudolaricis powder, Folium Artemisiae Argyi powder, Radix Sophorae Flavescentis powder, Herba Schizonepetae powder, Herba Ephedrae powder, Radix Tripterygii Wilfordii powder, Mirabilitum crystallina powder are poured into respectively in the mixer by described proportioning, fully promptly obtained the present composition behind the mixing.
In component of the present invention: Cortex Dictamni has effects such as heat clearing and damp drying, dispelling wind for relieving itching, detoxifcation, cures mainly diseases such as rubella due to the wind heat noxious dampness, eczema, scabies, jaundice, damp and hot numbness.Cortex Dictamni is distributed in ground such as China northeast, North China, East China and Shaanxi, and is on the books in medicine ancient books and records such as " property of medicine opinion ", Shennong's Herbal.
Fructus Cnidii another name Daucus carota L. with fruit medicine, is born in moist place such as open country, field, roadside, small stream limes marginis, and it is warm in nature, and acrid in the mouth, hardship cure mainly dampness, dispel the wind diseases such as parasite killing.Ground such as Fructus Cnidii main product Hebei, Zhejiang, Jiangsu, Sichuan, " Chinese pharmacopoeia, on the books in the medicine ancient books and records such as " Bencao Tujings ".
Effects such as the Cortex Pseudolaricis another name is gone up rose of Sharon skin, wattle skin, pseudolaricis,cortex, has parasite killing, and is antipruritic are had bactericidal action to permitting blue achorion, acrothesium floccosum, rust budlet spore tinea bacterium, microsporon gypseum and Candida albicans.Cortex Pseudolaricis is distributed in ground such as China Zhejiang, Anhui, Jiangsu, " on the books in the medicine ancient books and records such as Chinese pharmacopoeia.
Plucked when Folium Artemisiae Argyi summer, flower was opened, remove impurity, dry with leaf and be used as medicine, its property dispersing cold for relieving pain, warming the meridian for stopping bleeding, the external treatment skin pruritus, vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding is used for diseases such as deficiency and coldness is hemorrhage.Folium Artemisiae Argyi is distributed in ground such as China Heilungkiang, Jilin, Liaoning, Henan, and is on the books in medicine ancient books and records such as Collective Notes to the Canon of Materia medica.
Radix Sophorae Flavescentis cures mainly diseases such as damp-heat dysentery, discharging fresh blood stool, jaundice, edema, scabies, skin pruritus, noxious dampness skin infection.Radix Sophorae Flavescentis is distributed in all parts of the country, and is on the books in medicine ancient books and records such as Compendium of Material Medica.
Herba Schizonepetae popular name " Rhizoma Zingiberis Recens mustard " has the diffusing wind that induces sweat, rash, and the skin ulcer that disappears, effects such as hemostasis cure mainly measles and thoroughly send out not freely, have blood in stool, diseases such as metrorrhagia, epistaxis.Herba Schizonepetae is distributed in all parts of the country, and is in " herbal classic ", on the books in the medicine ancient books and records such as " Chinese medicinal herbals ".
Herba Ephedrae has the diaphoresis cold expelling, depressed lung-energy dispersing, and effects such as inducing diuresis to remove edema are used for chill exterior disease more.Herba Ephedrae is distributed in ground such as China North China and Jilin, Liaoning, and is on the books in medicine ancient books and records such as Shennong's Herbal.
Radix Tripterygii Wilfordii cries Caulis Fibraureae, beeswax rattan, cabbageworm medicine, red medicine, water Folium illicii Lanceolati again, and be used as medicine to have with root and dispel the wind, detoxifcation, effects such as parasite killing cure mainly rheumatic arthritis, skin disease such as itch.Radix Tripterygii Wilfordii originates in ground such as Zhejiang, Anhui, Jiangxi, Hunan, and is on the books in medicine ancient books and records such as " middle traditional Chinese medicines are planted will ", " national Chinese herbal medicine compilation ".
The Mirabilitum crystallina clearing away heat-fire, sharp key, detumescence is used for the calentura excessive thirst, diseases such as erysipelas scald.
The present invention is by selected drug component, reasonable compatibility, bring into play the synergism of each component, protein synthesis by disturbing responsive pathogenic microorganism and folic acid metabolism and the bacteria growing inhibiting breeding can be used for preventing and treating aquatic animal because of symptoms such as various antibacterials, fungus-caused black gill disease, the yellow gill, gill rot, brown patch, mashed tail, mashed bodies.Use the present invention, it is beautiful that water quality obviously becomes, and forage volume obviously increases, and steals deadly obviously to reduce, and its distinctive natural bioactivity substance can be regulated the metabolic function of body, helps the aquatic animal rehabilitation.Because it is the present invention is a pure Chinese medicinal preparation, without any side effects simultaneously, in the aquatic animal body, can not form drug residue.
The specific embodiment
Below by embodiment, technical scheme of the present invention is further described in detail.
Embodiment 1: with Cortex Dictamni, Fructus Cnidii, Cortex Pseudolaricis, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Herba Schizonepetae, Herba Ephedrae, Radix Tripterygii Wilfordii, Mirabilitum crystallina pulverize separately, cross 120 eye mesh screens and obtain drug powder; Above-mentioned powder is put into the baking oven inner drying respectively, 80 ℃ of bake out temperatures, dry 30 minutes; With (1 kilogram every part of 70 parts of dried Cortex Dictamni powder, down with), 20 parts in Fructus Cnidii powder, 10 parts in Cortex Pseudolaricis powder, 10 parts of Folium Artemisiae Argyi powders, 100 parts of Radix Sophorae Flavescentis powder, 10 parts in Herba Schizonepetae powder, 50 parts in Herba Ephedrae powder, 70 parts in Radix Tripterygii Wilfordii powder, Mirabilitum crystallina 10 powder pour into respectively in the mixer by described proportioning, fully promptly obtains the present composition behind the mixing.
Embodiment 2: with Cortex Dictamni, Fructus Cnidii, Cortex Pseudolaricis, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Herba Schizonepetae, Herba Ephedrae, Radix Tripterygii Wilfordii, Mirabilitum crystallina pulverize separately, cross 120 eye mesh screens and obtain drug powder; Above-mentioned powder is put into the baking oven inner drying respectively, 80 ℃ of bake out temperatures, dry 30 minutes; 60 parts of 5 parts of dried Cortex Dictamni powder, 160 parts in Fructus Cnidii powder, 100 parts in Cortex Pseudolaricis powder, 90 parts of Folium Artemisiae Argyi powders, 10 parts of Radix Sophorae Flavescentis powder, 100 parts in Herba Schizonepetae powder, 5 parts in Herba Ephedrae powder, 10 parts in Radix Tripterygii Wilfordii powder, Mirabilitum crystallina powder are poured into respectively in the mixer by described proportioning, fully promptly obtained the present composition behind the mixing.
Embodiment 3: with Cortex Dictamni, Fructus Cnidii, Cortex Pseudolaricis, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Herba Schizonepetae, Herba Ephedrae, Radix Tripterygii Wilfordii, Mirabilitum crystallina pulverize separately, cross 120 eye mesh screens and obtain drug powder; Above-mentioned powder is put into the baking oven inner drying respectively, 80 ℃ of bake out temperatures, dry 30 minutes; 45 parts of 20 parts of dried Cortex Dictamni powder, 120 parts in Fructus Cnidii powder, 80 parts in Cortex Pseudolaricis powder, 30 parts of Folium Artemisiae Argyi powders, 40 parts of Radix Sophorae Flavescentis powder, 85 parts in Herba Schizonepetae powder, 40 parts in Herba Ephedrae powder, 20 parts in Radix Tripterygii Wilfordii powder, Mirabilitum crystallina powder are poured into respectively in the mixer by described proportioning, fully promptly obtained the present composition behind the mixing.
Embodiment 4: with Cortex Dictamni, Fructus Cnidii, Cortex Pseudolaricis, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Herba Schizonepetae, Herba Ephedrae, Radix Tripterygii Wilfordii, Mirabilitum crystallina pulverize separately, cross 120 eye mesh screens and obtain drug powder; Above-mentioned powder is put into the baking oven inner drying respectively, 80 ℃ of bake out temperatures, dry 30 minutes; 20 parts of 70 parts of dried Cortex Dictamni powder, 35 parts in Fructus Cnidii powder, 30 parts in Cortex Pseudolaricis powder, 75 parts of Folium Artemisiae Argyi powders, 90 parts of Radix Sophorae Flavescentis powder, 35 parts in Herba Schizonepetae powder, 20 parts in Herba Ephedrae powder, 55 parts in Radix Tripterygii Wilfordii powder, Mirabilitum crystallina powder are poured into respectively in the mixer by described proportioning, fully promptly obtained the present composition behind the mixing.
Embodiment 5: with Cortex Dictamni, Fructus Cnidii, Cortex Pseudolaricis, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Herba Schizonepetae, Herba Ephedrae, Radix Tripterygii Wilfordii, Mirabilitum crystallina pulverize separately, cross 120 eye mesh screens and obtain drug powder; Above-mentioned powder is put into the baking oven inner drying respectively, 80 ℃ of bake out temperatures, dry 30 minutes; 25 parts of 50 parts of dried Cortex Dictamni powder, 75 parts in Fructus Cnidii powder, 50 parts in Cortex Pseudolaricis powder, 40 parts of Folium Artemisiae Argyi powders, 45 parts of Radix Sophorae Flavescentis powder, 45 parts in Herba Schizonepetae powder, 25 parts in Herba Ephedrae powder, 30 parts in Radix Tripterygii Wilfordii powder, Mirabilitum crystallina powder are poured into respectively in the mixer by described proportioning, fully promptly obtained the present composition behind the mixing.
Embodiment 6: with Cortex Dictamni, Fructus Cnidii, Cortex Pseudolaricis, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Herba Schizonepetae, Herba Ephedrae, Radix Tripterygii Wilfordii, Mirabilitum crystallina pulverize separately, cross 120 eye mesh screens and obtain drug powder; Above-mentioned powder is put into the baking oven inner drying respectively, 80 ℃ of bake out temperatures, dry 30 minutes; 20 parts of 10 parts of dried Cortex Dictamni powder, 140 parts in Fructus Cnidii powder, 25 parts in Cortex Pseudolaricis powder, 80 parts of Folium Artemisiae Argyi powders, 85 parts of Radix Sophorae Flavescentis powder, 25 parts in Herba Schizonepetae powder, 15 parts in Herba Ephedrae powder, 60 parts in Radix Tripterygii Wilfordii powder, Mirabilitum crystallina powder are poured into respectively in the mixer by described proportioning, fully promptly obtained the present composition behind the mixing.
Below further verify beneficial effect of the present invention by the curative effect of medication contrast test.
Experimental example 1: select to suffer from A, two mouthfuls of Macrobrachium nipponensis(de Haan) shrimps of B pond of black gill disease, A shrimp pool area is that 1.5 mu, shrimp quantity are tail surplus in the of 90,000; B shrimp pond is 1.5 mu, and shrimp quantity is tail surplus in the of 90,000.
The A pond is a test tank, and the embodiment of the invention 4 or 5 or 6 is made pharmaceutical composition, makes every mu of rice of pharmaceutical composition 150g the morning on daytime, evenly splashes in A shrimp pond logotype 2 days.And with this pharmaceutical composition and the abundant mixing of shrimp feedstuff, make bait feeding in the ratio of feedstuff gross weight 10%, once a day, threw something and fed continuously 5 days.
The B pond is the contrast pond, uses chlorine dioxide 1ppm～1.5ppm full pool spilling head, logotype 2 days the morning on daytime.Its therapeutic outcome is as shown in table 1:
Table 1: shrimp pond dispensing contrast test
Conclusion (of pressure testing): after test tank was used the present invention, sick shrimp symptom improved, and mortality rate is effectively controlled, and mortality rate only is 0.5%.Though the sick shrimp symptom in contrast pond makes moderate progress, mortality rate is than A pond height.Subsequently, the observation that A, B pond were carried out month by a definite date shows that A pond shoal of shrimps grows fine.Though B pond water body is through upgrading once more and handling, water quality is better, and sickness rate is still higher.
Experimental example 2: select to have two mouthfuls of fishponds of A, B of diseases such as black gill disease, gill rot, A fishpond area is that 3 mu, sick fish quantity are about 1000 tails; The B fishpond is 3.5 mu, and sick fish quantity is about 1200 tails.
The A pond is a test tank, and the embodiment of the invention 2 or 3 or 4 is made pharmaceutical composition,, once a day, throws something and feeds continuously 5～6 days this pharmaceutical composition and the abundant mixing of fish meal in the ratio of feedstuff gross weight 10%.
The B pond is the contrast pond, uses chlorine dioxide 1ppm～1.5ppm full pool spilling head, logotype 2 days the morning on daytime.It is peaceful to add the intestinal gill in the ratio of feedstuff gross weight 10%, makes bait feeding, once a day, throws something and feeds continuously 5～6 days.Its therapeutic outcome is as shown in table 2:
Table 2: fishpond dispensing contrast test
Conclusion (of pressure testing): after test tank was used the present invention, sick fish symptom improved, and mortality rate is effectively controlled, and mortality rate only is 0.25%.Though the sick fish symptom in contrast pond makes moderate progress, mortality rate still reaches 2%.
Claims (3)
1. pharmaceutical composition of preventing and treating aquatic animal black gill disease disease is characterized in that described pharmaceutical composition made by the following components in part by weight proportioning: 5 parts～70 parts of Cortex Dictamni, 20 parts～160 parts of Fructus Cnidiis, 10 parts～100 parts of Cortex Pseudolariciss, 10 parts～90 parts of Folium Artemisiae Argyis, 10 parts～100 parts of Radix Sophorae Flavescentiss, 10 parts～100 parts of Herba Schizonepetae, 5 parts～50 parts in Herba Ephedrae, 10 parts～70 parts of Radix Tripterygii Wilfordiis, 10 parts～60 parts of Mirabilitum crystallinas.
2. the pharmaceutical composition of preventing and treating aquatic animal black gill disease disease according to claim 1 is characterized in that the proportioning of described pharmaceutical composition is: 20 parts～70 parts of Cortex Dictamni, 35 parts～120 parts of Fructus Cnidiis, 30 parts～80 parts of Cortex Pseudolariciss, 30 parts～75 parts of Folium Artemisiae Argyis, 40 parts～90 parts of Radix Sophorae Flavescentiss, 35 parts～85 parts of Herba Schizonepetae, 20 parts～40 parts in Herba Ephedrae, 20 parts～55 parts of Radix Tripterygii Wilfordiis, 20 parts～45 parts of Mirabilitum crystallinas.
3. the pharmaceutical composition of preventing and treating aquatic animal black gill disease disease according to claim 2 is characterized in that the proportioning of described pharmaceutical composition is: 50 parts of Cortex Dictamni, 75 parts of Fructus Cnidiis, 50 parts of Cortex Pseudolariciss, 40 parts of Folium Artemisiae Argyis, 45 parts of Radix Sophorae Flavescentiss, 45 parts of Herba Schizonepetae, 25 parts in Herba Ephedrae, 30 parts of Radix Tripterygii Wilfordiis, 25 parts of Mirabilitum crystallinas.
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Cited By (1)
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