CN103285122B - Traditional Chinese medicine composition for treating swine mange and scab and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating swine mange and scab and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating swine mange. The traditional Chinese medicine comprises is prepared from the following raw medicines in parts by weight: 700 to 1,200 parts of bacopa monnieri, 500 to 1,000 parts of cortex dictamni, 300 to 800 parts of radix sophorae flavescentis, 300 to 800 parts of fructus cnidii, and 100 to 500 parts of sulphur. In addition, the invention also discloses a preparation method of the traditional Chinese medicine. The traditional Chinese medicine can be used both external and internal and can treat from external and internal; when in internal use, the traditional Chinese medicine composition has the effects of clearing heat and cooling blood, removing toxicity for detumescence, strengthening Yang and relaxing bowels, cleaning blood and promoting metabolism, and cuts off a nutrient source of sarcoptic mites so that the foundation for the sarcoptic mite to attach to a swine body is removed; when in external use, the traditional Chinese medicine composition has the effects of disinfecting and disinsectizing, eliminating dampness and relieving itching, promoting tissue regeneration and repairing epidermal tissue, and can control the disease quickly; by adopting such combination, the best of each raw medicine is brought out, good effect of treating both symptoms and root causes is realized, and thus the swine mange and scab can be cured completely.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind ofly treat Chinese medicine composition of pig mange and scab and preparation method thereof.
Background technology
Pig scabies is one the most general and the most serious in porcine skin disease, pig scabies usually originate in head, near the eyes, buccal and ear, spread to inside back, side and stock later, especially multiple with piglet and degree is heavier.Sick pig performance play is itched, and friction is everywhere so that galling is hemorrhage, and affected part depilation, incrustation, pachyderma, form gauffer and be full of cracks, loss of appetite, growth retardation, becomes thin gradually, and serious caused exhaustion is dead.Primary disease is mainly in the pig at 5 monthly ages below, and the grower pigs main manifestations of more than 25kg is for cough and breathe, and has partly have loose bowels symptom or respiratory symptom.Under summer and autumn hot climate, pig body is shown in that many circles give prominence to the erythema of skin surface, and winter then obviously reduces or do not have.This sick large and small pig all can infect, and has a strong impact on the growth promoter of pig, and to raising pigs, industrial belt carrys out huge economic loss.
At present, the medicine one of primary treatment pig scabies is with 2% metrifonate aqueous solution shampooing affected part or spray pig body on the market; Two is with ivermectin or the every kg body weight of avilamycin 0.3 gram of subcutaneous injection, or 0.25% single first miaow, 2 spray pig bodies etc. weekly, but in fact these medicines are all undesirable to the therapeutic effect of pig scabies, be difficult to reach the object of thoroughly curing pig scabies, in addition, have drug safety wayward, affect meat quality, and medicine not easily absorbs, onset is slow, the easy shortcoming such as recurrence.
Summary of the invention
Technical problem to be solved by this invention is for above-mentioned the deficiencies in the prior art, provides a kind of Chinese medicine composition for the treatment of pig mange and scab.Same use inside and outside this Chinese medicine composition, inside and outside rule together, interiorly play supporing yang relieving constipation with having clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling, cleaning blood, the effect enhanced metabolism, prevents the parasitic source of nutrition of acaricide, and loses the basis being attached to pig body; External energy disinfection, dampness removing to stop itchin, granulation promoting antiinflammatory, repair effect of epidermal tissue, can control the state of an illness rapidly, this compatibility brings out the best in each other, and plays the good result for the treatment of both the principal and secondary aspects of a disease, thus can thoroughly cure pig mange and scab.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine composition for the treatment of pig mange and scab, it is characterized in that, be made up of the crude drug of following weight portion: spend the female dish 700-1200 parts of pig in vain, Cortex Dictamni 500-1000 parts, Radix Sophorae Flavescentis 300-800 parts, Fructus Cnidii 300-800 parts, sulfur 100-500 parts.
Above-mentioned a kind of Chinese medicine composition for the treatment of pig mange and scab, is made up of the crude drug of following weight portion: spend the female dish 800-1100 parts of pig in vain, Cortex Dictamni 600-700 parts, Radix Sophorae Flavescentis 400-600 parts, Fructus Cnidii 400-600 parts, sulfur 200-400 parts.
Above-mentioned a kind of Chinese medicine composition for the treatment of pig mange and scab, is made up of the crude drug of following weight portion: spend the female dish 1000 parts of pig in vain, Cortex Dictamni 700 parts, Radix Sophorae Flavescentis 500 parts, Fructus Cnidii 500 parts, sulfur 300 parts.
Above-mentioned a kind of Chinese medicine composition for the treatment of pig mange and scab, the dosage form of described Chinese medicine composition is oral formulations or external preparation.
In addition, present invention also offers the method preparing above-mentioned Chinese medicine composition, it is characterized in that, the method comprises the following steps:
Step one, take and spend pig female dish, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain by weight, each medical material taken is cleaned respectively;
Step 2, the Fructus Cnidii after cleaning in step one to be crushed, the Cortex Dictamni after cleaning in step one and Radix Sophorae Flavescentis are ground into 24 object coarse powder respectively;
Step 3, flown by the sulfur water after cleaning in step one, cross 150 mesh sieves after drying in the shade, extracting screen underflow is for subsequent use;
Step 4, the female dish cutting of pig will be spent in vain after cleaning in step one, then twice is soaked, each amount of water is 7 ~ 9 times that spend the female dish weight of pig in vain, each soaking temperature is 70 DEG C ~ 90 DEG C, each soak time is 1h ~ 3h, merge the soak of twice immersion, after filtration, concentrating filtrate to weight is the concentrated medicament A of 3 ~ 5 times that crude drug spends the female dish weight of pig in vain;
Step 5, the coarse powder of Cortex Dictamni described in step 2, Radix Sophorae Flavescentis coarse powder and the Fructus Cnidii after crushing are loaded taper diffusiometer, then in diffusiometer, add soak with ethanol 10h ~ 15h that mass percent concentration is 70% ~ 75%, then the leak rate of described taper diffusiometer is adjusted to 4mL/min ~ 5mL/min and carries out seepage, collect effusion, again the effusion collected is filtered, concentrate filtrate to the concentrated medicament B that weight is crude drug Cortex Dictamni, Radix Sophorae Flavescentis and Fructus Cnidii gross weight 2 ~ 3 times; The addition of described ethanol is 8 ~ 12 times of crude drug Cortex Dictamni, Radix Sophorae Flavescentis and Fructus Cnidii gross weight;
Step 6, by concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in step 3, step 4 and step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions, wherein the method for equal portions conveniently oral formulations makes oral formulations, and the method for other equal portions conveniently external preparation makes external preparation.
Above-mentioned method, the pressure of concentrating under reduced pressure described in step 4 is-0.03MPa ~-0.08MPa, and temperature is 60 DEG C ~ 80 DEG C.
Above-mentioned method, the pressure of concentrating under reduced pressure described in step 5 is-0.03MPa ~-0.08MPa, and temperature is 60 DEG C ~ 80 DEG C.
Described weight portion can be gram, two, jin, kilogram, Dun Deng weight metering unit.
Spending the female dish of pig in vain is that Scrophulariaceae crawls the herb of herbaceous plant Herba Bacopae monnieri, taste is micro-sweet, light, cold in nature, main containing spending the female dish Saponin of pig A and B in vain, generate glucose, arabinose through acid hydrolysis and spend pig female dish ruscogenin A1, A2, A3 and A4 in vain, summer, autumn gather, cutting is dried, and has clearing away heat and cooling blood, effect of removing toxic substances and promoting subsidence of swelling.Cortex Dictamni is the root bark of Rutaceae herbaceos perennial shaggy-fruited dittany and Dictamnus angustifolius, bitter in the mouth, salty, cold, return spleen channel, lung meridian, small intestine meridian, stomach warp, urinary bladder channel, the chemical composition of Cortex Dictamni mainly contains dictamine, dictamnolactone, shaggy-fruited dittany brain lactide, Xi ketone, obacunone etc., wherein the pharmacological action of dictamine, Xi ketone, obacunone three kinds of compositions can represent Cortex Dictamni and the effect in compound recipe thereof substantially, spring, Qiu Erji excavate root, removing silt and rough bark, strip root bark, section, dry, raw use, there is heat clearing and damp drying, the effect of detoxifying and relieving itching of dispeling the wind.Radix Sophorae Flavescentis is the root of perennial fallen leaves semishrub plant Radix Sophorae Flavescentis, and bitter in the mouth is cold in nature, return liver, kidney, large intestine, small intestine meridian, heart channel, urinary bladder channel, mainly containing matrine, oxymatrine, sophoridine, kurarinone, also containing Radix Sophorae Flavescentis saponin I, II, III, IV, soyasaponins I and quinones Radix Sophorae Flavescentis quinone A, kurarinone etc., annual spring and autumn is gathered into medicinal, there is heat clearing and damp drying, wind dispelling insecticide, main treatment skin pruritus, blood tinea corporis skin ulcer, naughty white scales, pathogenic wind expelling, detumescence poison, expectorant poison, the disease such as to relieving asthma.Fructus Cnidii is samphire cnidium monnieri Cnidium monnieri(L.) dry mature fruit of Cuss., acrid in the mouth, hardship, warm in nature, return spleen channel, kidney channel, main component is pinene, camphene, the acid of different one-tenth borneol acetate, isoborneol, gather when summer, autumn two season fruit maturation, removing impurity, dries, tool warming the kidney to invigorate YANG, removing dampness and killing parasites, dispelling wind for relieving itching, the effect of relievining asthma.Sulfur is native element class mineral sulfur family sulphurite, after excavating, heat fused, removing impurity, or it is obtained through processing with containing sulfur minerals, sour in the mouth, warm in nature, return kidney, large intestine channel, main containing elemental sulfur S8, still there are a small amount of calcium, ferrum, aluminum, magnesium and the element such as trace selenium, tellurium, there is removing toxic substances killing parasites for relieving itching, mend effect of fiery supporing yang relieving constipation.The present invention is to spend the female dish of pig and Cortex Dictamni in vain for monarch drug, be aided with monarch drug with Radix Sophorae Flavescentis, Fructus Cnidii, sulfur three taste ministerial drug and spend pig female dish, Cortex Dictamni in vain, inside and outside same use, inside and outside rule together, and reach clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling, play supporing yang relieving constipation, cleaning blood, the merit enhanced metabolism, and realize disinfection, dampness removing to stop itchin, granulation promoting antiinflammatory, repairs the effect of epidermal tissue, controls the state of an illness rapidly.
The usage and dosage of Chinese medicine composition of the present invention:
1, oral solutions usage and dosage: oral, by each 1.5mL/kg of pig body weight, every day 3 times;
2, granular preparation usage and dosage: oral, by each 0.5g/kg of pig body weight, every day 3 times;
3, pill usage and dosage: oral, by each 0.5g/kg of pig body weight, every day 3 times;
4, tablet usage and dosage: oral, by each 0.5g/kg of pig body weight, every day 3 times;
5, spray usage and dosage: external, each used time shakes up and is sprayed at porcine skin surface and pig house, by each 2.0mL/kg of pig body weight, every day 3 times;
6, ointment usage and dosage: external, uniform application is surperficial in porcine skin, by each 0.5g/kg of pig body weight, every day 3 times;
7, gel usage and dosage: external, uniform application is surperficial in porcine skin, by each 0.5g/kg of pig body weight, every day 3 times.
The present invention compared with prior art has the following advantages:
1, the invention belongs to pure Chinese medicinal preparation, other internal organs are had no side effect, treating both the principal and secondary aspects of a disease.
2, Chinese medicine composition of the present invention is without specific peculiar smell, and large and small pig is all suitable, takes safety, and good absorption, easily preserves, can guarantee the quality 2 years.
3, same use inside and outside Chinese medicine composition of the present invention, inside and outside rule together, interiorly play supporing yang relieving constipation with having clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling, cleaning blood, the effect enhanced metabolism, prevents the parasitic source of nutrition of acaricide, and loses the basis being attached to pig body; External energy disinfection, dampness removing to stop itchin, granulation promoting antiinflammatory, repair effect of epidermal tissue, can control the state of an illness rapidly, this compatibility brings out the best in each other, and plays the good result for the treatment of both the principal and secondary aspects of a disease, thus can thoroughly cure pig mange and scab.
4, Traditional Chinese medicine composition formula of the present invention is unique, cure rate is high, safety is high, relapse rate is low, stability is strong, have no side effect, treating both the principal and secondary aspects of a disease, affected pig with after do not develop complications, the untoward reaction such as recurrence, the popularization of applicable marketing drugs.
Below by embodiment, technical scheme of the present invention is described in further detail.
Detailed description of the invention
Embodiment 1
The Chinese medicine composition of the present embodiment is made up of following crude drug: spend the female dish 1000g of pig in vain, Cortex Dictamni 700g, Radix Sophorae Flavescentis 500g, Fructus Cnidii 500g, sulfur 300g.
The Chinese medicine composition dosage form of the present embodiment is oral solutions and spray.
The preparation method of the Chinese medicine composition of the present embodiment is:
Step one, to take by formula and spend pig female dish, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain, each medical material taken is cleaned respectively;
Step 2, the Fructus Cnidii after cleaning in step one to be crushed, the Cortex Dictamni after cleaning in step one and Radix Sophorae Flavescentis are ground into 24 object coarse powder respectively;
Step 3, fly to impalpable powder by the sulfur water after cleaning in step one, cross 150 mesh sieves after drying in the shade, extracting screen underflow is for subsequent use;
Step 4, the female dish cutting of pig will be spent in vain after cleaning in step one, then twice is soaked, each amount of water is 8 times that spend the female dish weight of pig in vain, each soaking temperature is 80 DEG C, each soak time is 2h, merge the soak of twice immersion, after filtration, concentrate filtrate to the concentrated medicament A that weight is 4000g; The pressure of described concentrating under reduced pressure is-0.05MPa, and temperature is 70 DEG C;
Step 5, the coarse powder of Cortex Dictamni described in step 2, Radix Sophorae Flavescentis coarse powder and the Fructus Cnidii after crushing are loaded taper diffusiometer, then in diffusiometer, the soak with ethanol 12h that 17kg mass percent concentration is 70% is added, then the leak rate of described taper diffusiometer is adjusted to 4.5mL/min and carries out seepage, collect effusion, again the effusion collected is filtered, concentrate filtrate to the concentrated medicament B that weight is 4000g; The pressure of described concentrating under reduced pressure is-0.05MPa, and temperature is 70 DEG C;
Step 6, by concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in step 3, step 4 and step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions; 300mL Tween 80 and 100g sodium benzoate is added wherein, the oral liquid of the pig mange and scab that obtains medical treatment after mix homogeneously in equal portions; 300mL Tween 80,100g sodium benzoate and 300mL dimethyl sulfoxide is added, the spray of the pig mange and scab that obtains medical treatment after mix homogeneously in other equal portions.
Embodiment 2
The Chinese medicine composition of the present embodiment is made up of following crude drug: spend the female dish 1200kg of pig in vain, Cortex Dictamni 500kg, Radix Sophorae Flavescentis 300kg, Fructus Cnidii 800kg, sulfur 100kg.
The Chinese medicine composition dosage form of the present embodiment is granule and ointment.
The preparation method of the Chinese medicine composition of the present embodiment is:
Step one, to take by formula and spend pig female dish, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain, each medical material taken is cleaned respectively;
Step 2, the Fructus Cnidii after cleaning in step one to be crushed, the Cortex Dictamni after cleaning in step one and Radix Sophorae Flavescentis are ground into 24 object coarse powder respectively;
Step 3, fly to impalpable powder by the sulfur water after cleaning in step one, cross 150 mesh sieves after drying in the shade, extracting screen underflow is for subsequent use;
Step 4, the female dish cutting of pig will be spent in vain after cleaning in step one, then twice is soaked, each amount of water is 9 times that spend the female dish weight of pig in vain, each soaking temperature is 90 DEG C, each soak time is 1h, merge the soak of twice immersion, after filtration, concentrate filtrate to the concentrated medicament A that weight is 3600kg; The pressure of described concentrating under reduced pressure is-0.03MPa, and temperature is 80 DEG C;
Step 5, the coarse powder of Cortex Dictamni described in step 2, Radix Sophorae Flavescentis coarse powder and the Fructus Cnidii after crushing are loaded taper diffusiometer, then in diffusiometer, the soak with ethanol 10h that 12800kg mass percent concentration is 75% is added, then the leak rate of described taper diffusiometer is adjusted to 4mL/min and carries out seepage, collect effusion, again the effusion collected is filtered, concentrate filtrate to the concentrated medicament B that weight is 4800kg; The pressure of described concentrating under reduced pressure is-0.03MPa, and temperature is 60 DEG C;
Step 6, by concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in step 3, step 4 and step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions; The method of wherein equal portions granule processed is routinely made granule, pack, and every bag is equivalent to crude drug 20g; The method of another equal portions ointment processed is routinely made ointment, tubulature, and often pipe 100g, often pipe is equivalent to crude drug 100g.
Embodiment 3
The Chinese medicine composition of the present embodiment is made up of following crude drug: spend the female dish 700g of pig in vain, Cortex Dictamni 1000g, Radix Sophorae Flavescentis 800g, Fructus Cnidii 300g, sulfur 500g.
The Chinese medicine composition dosage form of the present embodiment is pill and ointment.
The preparation method of the Chinese medicine composition of the present embodiment is:
Step one, to take by formula and spend pig female dish, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain, each medical material taken is cleaned respectively;
Step 2, the Fructus Cnidii after cleaning in step one to be crushed, the Cortex Dictamni after cleaning in step one and Radix Sophorae Flavescentis are ground into 24 object coarse powder respectively;
Step 3, fly to impalpable powder by the sulfur water after cleaning in step one, cross 150 mesh sieves after drying in the shade, extracting screen underflow is for subsequent use;
Step 4, the female dish cutting of pig will be spent in vain after cleaning in step one, then twice is soaked, each amount of water is 7 times that spend the female dish weight of pig in vain, each soaking temperature is 70 DEG C, each soak time is 3h, merge the soak of twice immersion, after filtration, concentrate filtrate to the concentrated medicament A that weight is 3500g; The pressure of described concentrating under reduced pressure is-0.08MPa, and temperature is 70 DEG C;
Step 5, the coarse powder of Cortex Dictamni described in step 2, Radix Sophorae Flavescentis coarse powder and the Fructus Cnidii after crushing are loaded taper diffusiometer, then in diffusiometer, the soak with ethanol 15h that 25.2kg mass percent concentration is 73% is added, then the leak rate of described taper diffusiometer is adjusted to 5mL/min and carries out seepage, collect effusion, again the effusion collected is filtered, concentrate filtrate to the concentrated medicament B that weight is 4200g; The pressure of described concentrating under reduced pressure is-0.08MPa, and temperature is 70 DEG C;
Step 6, by concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in step 3, step 4 and step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions; The method of wherein equal portions pill agent is routinely made pill, and every ball is equivalent to crude drug 10g; The method of another equal portions ointment processed is routinely made ointment, tubulature, and often pipe 100g, often pipe is equivalent to crude drug 100g.
Embodiment 4
The Chinese medicine composition of the present embodiment is made up of following crude drug: spend the female dish 800kg of pig in vain, Cortex Dictamni 700kg, Radix Sophorae Flavescentis 400kg, Fructus Cnidii 400kg, sulfur 200kg.
The Chinese medicine composition dosage form of the present embodiment is oral solutions and spray.
The preparation method of the Chinese medicine composition of the present embodiment is:
Step one, to take by formula and spend pig female dish, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain, each medical material taken is cleaned respectively;
Step 2, the Fructus Cnidii after cleaning in step one to be crushed, the Cortex Dictamni after cleaning in step one and Radix Sophorae Flavescentis are ground into 24 object coarse powder respectively;
Step 3, fly to impalpable powder by the sulfur water after cleaning in step one, cross 150 mesh sieves after drying in the shade, extracting screen underflow is for subsequent use;
Step 4, the female dish cutting of pig will be spent in vain after cleaning in step one, then twice is soaked, each amount of water is 7 times that spend the female dish weight of pig in vain, each soaking temperature is 90 DEG C, first time soaks 2h, and second time soaks 3h, merges the soak of twice immersion, after filtration, concentrate filtrate to the concentrated medicament A that weight is 4000kg; The pressure of described concentrating under reduced pressure is-0.05MPa, and temperature is 80 DEG C;
Step 5, the coarse powder of Cortex Dictamni described in step 2, Radix Sophorae Flavescentis coarse powder and the Fructus Cnidii after crushing are loaded taper diffusiometer, then in diffusiometer, the soak with ethanol 13h that 15000kg mass percent concentration is 70% is added, then the leak rate of described taper diffusiometer is adjusted to 4mL/min and carries out seepage, collect effusion, again the effusion collected is filtered, concentrate filtrate to the concentrated medicament B that weight is 3000kg; The pressure of described concentrating under reduced pressure is-0.08MPa, and temperature is 70 DEG C;
Step 6, by concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in step 3, step 4 and step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions; 300L Tween 80 and 100kg sodium benzoate is added wherein, the oral liquid of the pig mange and scab that obtains medical treatment after mix homogeneously in equal portions; 300L Tween 80,100kg sodium benzoate and 300L dimethyl sulfoxide is added, the spray of the pig mange and scab that obtains medical treatment after mix homogeneously in another equal portions.
Embodiment 5
The Chinese medicine composition of the present embodiment is made up of following crude drug: spend the female dish 1100g of pig in vain, Cortex Dictamni 600g, Radix Sophorae Flavescentis 600g, Fructus Cnidii 600g, sulfur 400g.
The Chinese medicine composition dosage form of the present embodiment is tablet and gel.
The preparation method of the Chinese medicine composition of the present embodiment is:
Step one, to take by formula and spend pig female dish, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain, each medical material taken is cleaned respectively;
Step 2, the Fructus Cnidii after cleaning in step one to be crushed, the Cortex Dictamni after cleaning in step one and Radix Sophorae Flavescentis are ground into 24 object coarse powder respectively;
Step 3, fly to impalpable powder by the sulfur water after cleaning in step one, cross 150 mesh sieves after drying in the shade, extracting screen underflow is for subsequent use;
Step 4, the female dish cutting of pig will be spent in vain after cleaning in step one, then twice is soaked, each amount of water is 8 times that spend the female dish weight of pig in vain, each soaking temperature is 80 DEG C, first time soaks 3h, and second time soaks 2h, merges the soak of twice immersion, after filtration, concentrate filtrate to the concentrated medicament A that weight is 5000g; The pressure of described concentrating under reduced pressure is-0.03MPa, and temperature is 60 DEG C;
Step 5, the coarse powder of Cortex Dictamni described in step 2, Radix Sophorae Flavescentis coarse powder and the Fructus Cnidii after crushing are loaded taper diffusiometer, then in diffusiometer, the soak with ethanol 10h that 21.6kg mass percent concentration is 75% is added, then the leak rate of described taper diffusiometer is adjusted to 5mL/min and carries out seepage, collect effusion, again the effusion collected is filtered, concentrate filtrate to the concentrated medicament B that weight is 4500g; The pressure of described concentrating under reduced pressure is-0.05MPa, and temperature is 80 DEG C;
Step 6, by concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in step 3, step 4 and step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions; The method of wherein equal portions film-making agent is routinely made tablet, and every sheet is equivalent to crude drug 1g; The method of another equal portions gel processed is routinely made gel, tubulature, and often pipe is equivalent to crude drug 100g.
The usage and dosage of Chinese medicine composition of the present invention:
1, oral solutions usage and dosage: oral, by each 1.5mL/kg of pig body weight, every day 3 times;
2, granular preparation usage and dosage: oral, by each 0.5g/kg of pig body weight, every day 3 times;
3, pill usage and dosage: oral, by each 0.5g/kg of pig body weight, every day 3 times;
4, tablet usage and dosage: oral, by each 0.5g/kg of pig body weight, every day 3 times;
5, spray usage and dosage: external, each used time shakes up and is sprayed at porcine skin surface and pig house, by each 2.0mL/kg of pig body weight, every day 3 times;
6, ointment usage and dosage: external, uniform application is surperficial in porcine skin, by each 0.5g/kg of pig body weight, every day 3 times;
7, gel usage and dosage: external, uniform application is surperficial in porcine skin, by each 0.5g/kg of pig body weight, every day 3 times.
The diagnostic criteria of pig mange and scab curative effect:
Criterion of cure: pig mange and scab symptom disappears completely, without any discomfort, has no recurrence.
Effective standard: erubescence, serosity infiltrates transference cure, the cough of grower pigs and breathe, transference cure is itched in play.
Effective standard: symptom obviously alleviates, occasionally has cough and breathes or disease of slightly itching.
Null criterion: symptom, sign is without obvious change.
General clinical data: clinical observation case of the present invention is totally 110 examples, in 1.5 months to 5 months age of pig, wherein boar 58, sow 52,110 routine affected pigs, all more than 1 month, are divided into two groups by medical history at random, treatment group 60 example, matched group 50 example.Treatment group is for oral administration and external oral solutions of the present invention and spray simultaneously.Oral solutions is for oral administration, mixs homogeneously with pig feed at every turn, and consumption presses pig body weight 1.5mL/kg, every day 3 times; Spray is external, and each used time shakes up and is sprayed at porcine skin surface and pig house, and consumption, by pig body weight 2.0mL/kg, every day 3 times, 5 days courses for the treatment of, uses two courses for the treatment of; In matched group, 25 examples 2% metrifonate aqueous solution shampooing affected part or spray pig body, remains the every kg body weight of 25 example ivermectin 0.3 gram of subcutaneous injection, 5 days courses for the treatment of, uses two courses for the treatment of in matched group.
Table 1 clinical efficacy results contrast
Clinical observation case of the present invention is totally 110 examples, 1.5 months to 5 months age of pig, wherein boar 58, sow 52, and 110 routine affected pigs, all more than 1 month, are divided into two groups by medical history at random, treatment group 60 example, matched group 50 example.Treatment group is for oral administration and external oral solutions of the present invention and spray simultaneously.Oral solutions is for oral administration, mixs homogeneously with pig feed at every turn, and consumption presses pig body weight 1.5mL/kg, every day 3 times; Spray is external, and each used time shakes up and is sprayed at porcine skin surface and pig house, and consumption, by pig body weight 2.0mL/kg, every day 3 times, 5 days courses for the treatment of, uses two courses for the treatment of; In matched group, 25 examples 2% metrifonate aqueous solution shampooing affected part or spray pig body, remains the every kg body weight of 25 example ivermectin 0.3 gram of subcutaneous injection, 5 days courses for the treatment of, uses two courses for the treatment of in matched group.Treatment group compares with matched group general curative effect, and its result is the routine oral oral liquid of the present invention for the treatment of group 60, and external spray of the present invention, cure 48 examples, account for 80%, effective 9 examples, account for 15%, and effective 3 examples, account for 5%, total effective rate 100%.Matched group 25 example 2% metrifonate aqueous solution, cures 9 examples, accounts for 36%, and effective 7 examples, account for 28%, and effective 3 examples, account for 12%, and invalid 6 examples, account for 24%, total effective rate 76%; The matched group every kg body weight of other 25 example ivermectin 0.3 gram of subcutaneous injection, cures 8 examples, accounts for 32%, and effective 8 examples, account for 32%, and effective 2 examples, account for 8%, and invalid 7 examples, account for 28%, total effective rate 72%; Mostly that cures in matched group is slight affected pig, and easily recurs in therapeutic process, and treatment group and matched group compare curative effect there were significant differences.Traditional Chinese medicine composition formula of the present invention is unique, cure rate is high, safety is high, relapse rate is low, stability is strong, have no side effect, treating both the principal and secondary aspects of a disease, affected pig with after do not develop complications, the untoward reaction such as recurrence, the popularization of applicable marketing drugs.
Model case
Case 1
White pig is hybridized at two that lawn town, Zuoshui County lawn village pig farmer Wu feeds, and body weight is respectively 27kg and 30kg.In the equal affected pig mange and scab of in late March, 2010, be neck at first, back and belly portion infect, after be extended down to whole body, pars affecta skin thickens, and has wrinkle, and sick pig appetite is depressed, becomes thin, and very itches, and circle interior walls friction of being everlasting, some places have galled hemorrhage, and have serious scar.Through mixing homogeneously with pig feed with Chinese medicine composition oral solutions of the present invention at every turn, consumption presses pig body weight 1.5mL/kg, every day 3 times; Externally applied spray each used time shakes up and is sprayed at porcine skin surface and pig house, and consumption is by pig body weight 2.0mL/kg, and every day 3 times, for oral administration and external uses simultaneously, is used in conjunction 5 days, and pars affecta skin recovers normal.Continue use 4 days again later, all cure, do not fall ill again.
Case 2
Gold stand village, tile-roofed house mouth town, Zuoshui County certain 9 pig raised with circle of pig farmer gold, every body weight is at about 23kg, in in late April, 2011, find that there is a pig cervical region and back generation pig scabies, affected pig is acutely wiped and is itched, and after 9 days, other 8 are also infected in succession, wherein have 2 more serious, through mixing homogeneously with pig feed with Chinese medicine composition oral solutions of the present invention at every turn, consumption presses pig body weight 1.5mL/kg, every day 3 times; Externally applied spray each used time shakes up and is sprayed at porcine skin surface and pig house, and consumption is by pig body weight 2.0mL/kg, and every day 3 times, for oral administration and external uses simultaneously, is used in conjunction 5 days, and pars affecta skin recovers normal.Continue use 5 days again later, all cure, do not fall ill again.
Case 3
Tile-roofed house mouth town, Zuoshui County Jin Long village pig farmer Wang has raised 5 black hybridization breeding pigs with circle, every body weight is at about 26kg, in in mid-April, 2012, find that every pig has in various degree and wipe the situation of itching at colony house wall, within 6 days subsequently, this situation is more violent, and there is pimple at the cervical region of pig and back gradually, vesicle, incrustation depilation after ulceration, also show as body temperature to raise simultaneously, general skin rubefaction, there is yellowish-brown fat exudate, smell foul smell, through mixing homogeneously with pig feed with Chinese medicine composition oral solutions of the present invention at every turn, consumption is by pig body weight 1.5mL/kg, every day 3 times, externally applied spray each used time shakes up and is sprayed at porcine skin surface and pig house, and consumption is by pig body weight 2.0mL/kg, and every day 3 times, for oral administration and external uses simultaneously, is used in conjunction 5 days, and pars affecta skin recovers normal.Continue use 5 days again later, all cure, do not fall ill again.
Case 4
After tile-roofed house mouth town, Zuoshui County bright moon live pig seed breeding farm newly enters a collection of replacement gilt in May, 2011, except in more than 30 days 10 ages in days, piglet has no except manifest symptom, all the other 63 the equal affected pig mange and scabs of each stage pig, sickness rate 90%.Through inquiry, poultry is main reflects that most of sick piglet constitution is weak, dysplasia, and spirit is depressed.Check main the taken sick piglet of poultry, mainly chafing, depilation, very itch, hemorrhage, in eczmatous pathological changes, the piglet mouth having body constitution comparatively good, eyes, ear surrounding skin are rubescent, occur pimple, vesicle, and after ulceration, incrustation is lost hair or feathers.The Low piglet in two is apart from outside above-mentioned symptom in addition, and also show as body temperature and raise, general skin rubefaction, have yellowish-brown fat exudate, smell foul smell, epidermis thickens, dry, chaps.Through mixing homogeneously with pig feed with Chinese medicine composition oral solutions of the present invention at every turn, consumption presses pig body weight 1.5mL/kg, every day 3 times; Externally applied spray each used time shakes up and is sprayed at porcine skin surface and pig house, and consumption is by pig body weight 2.0mL/kg, and every day 3 times, for oral administration and external uses simultaneously, and after half day, gargalesthesia subtracts greatly; Treat after 2 days, no longer rub antipruritic, be used in conjunction 5 days, pars affecta skin recovers normal.Continue use 5 days again later, all cure, do not fall ill again.
Claims (3)
1. treat a Chinese medicine composition for pig mange and scab, it is characterized in that, be made up of the crude drug of following weight portion: spend the female dish 1000 parts of pig in vain, Cortex Dictamni 700 parts, Radix Sophorae Flavescentis 500 parts, Fructus Cnidii 500 parts, sulfur 300 parts;
The dosage form of described Chinese medicine composition is oral formulations and external preparation;
The preparation method of this Chinese medicine composition, comprises the following steps:
Step one, take and spend pig female dish, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain by weight, each medical material taken is cleaned respectively;
Step 2, the Fructus Cnidii after cleaning in step one to be crushed, the Cortex Dictamni after cleaning in step one and Radix Sophorae Flavescentis are ground into 24 object coarse powder respectively;
Step 3, flown by the sulfur water after cleaning in step one, cross 150 mesh sieves after drying in the shade, extracting screen underflow is for subsequent use;
Step 4, the female dish cutting of pig will be spent in vain after cleaning in step one, then twice is soaked, each amount of water is 7 ~ 9 times that spend the female dish weight of pig in vain, each soaking temperature is 70 DEG C ~ 90 DEG C, each soak time is 1h ~ 3h, merge the soak of twice immersion, after filtration, concentrating filtrate to weight is the concentrated medicament A of 3 ~ 5 times that crude drug spends the female dish weight of pig in vain;
Step 5, the coarse powder of Cortex Dictamni described in step 2, Radix Sophorae Flavescentis coarse powder and the Fructus Cnidii after crushing are loaded taper diffusiometer, then in diffusiometer, add soak with ethanol 10h ~ 15h that mass percent concentration is 70% ~ 75%, then the leak rate of described taper diffusiometer is adjusted to 4mL/min ~ 5mL/min and carries out seepage, collect effusion, again the effusion collected is filtered, concentrate filtrate to the concentrated medicament B that weight is crude drug Cortex Dictamni, Radix Sophorae Flavescentis and Fructus Cnidii gross weight 2 ~ 3 times; The addition of described ethanol is 8 ~ 12 times of crude drug Cortex Dictamni, Radix Sophorae Flavescentis and Fructus Cnidii gross weight;
Step 6, by concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in step 3, step 4 and step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions, wherein the method for equal portions conveniently oral formulations makes oral formulations, and the method for other equal portions conveniently external preparation makes external preparation.
2. a kind of Chinese medicine composition for the treatment of pig mange and scab according to claim 1, is characterized in that, the pressure of concentrating under reduced pressure described in step 4 is-0.03MPa ~-0.08MPa, and temperature is 60 DEG C ~ 80 DEG C.
3. a kind of Chinese medicine composition for the treatment of pig mange and scab according to claim 1, is characterized in that, the pressure of concentrating under reduced pressure described in step 5 is-0.03MPa ~-0.08MPa, and temperature is 60 DEG C ~ 80 DEG C.
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| CN104666403A (en) * | 2013-12-03 | 2015-06-03 | 天津市中敖饲料有限公司 | Liniment for treating acariasis of domestic animal and preparation method thereof |
| CN105456804A (en) * | 2016-01-22 | 2016-04-06 | 冯悠慈 | Traditional Chinese medicine composition for treating pig mange sickness and preparation method and application thereof |
| CN105963442A (en) * | 2016-07-03 | 2016-09-28 | 张俊清 | Mongolian medicine composition for treating sheep scab disease |
| CN106362057A (en) * | 2016-08-26 | 2017-02-01 | 任英明 | Traditional Chinese veterinary medicine for treating swine scabies |
| CN106581541A (en) * | 2016-12-05 | 2017-04-26 | 张明 | Traditional Chinese medicine composition for treating pig scabies |
| CN106728153A (en) * | 2016-12-12 | 2017-05-31 | 张俊清 | A kind of Chinese medicine composition for treating rabbits mange |
| CN107029158B (en) * | 2017-05-01 | 2020-02-28 | 天水师范学院 | Compound Chinese herbal medicine external preparation for treating rabbit mange ringworm |
| CN109125654A (en) * | 2018-10-26 | 2019-01-04 | 申亚农牧科技股份有限公司 | It is a kind of for treating the Chinese traditional medicine composition liquid and preparation method of pig mustard tinea |
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