CN103285122A - Traditional Chinese medicine composition for treating swine mange and scab and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating swine mange and scab and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating swine mange. The traditional Chinese medicine comprises is prepared from the following raw medicines in parts by weight: 700 to 1,200 parts of bacopa monnieri, 500 to 1,000 parts of cortex dictamni, 300 to 800 parts of radix sophorae flavescentis, 300 to 800 parts of fructus cnidii, and 100 to 500 parts of sulphur. In addition, the invention also discloses a preparation method of the traditional Chinese medicine. The traditional Chinese medicine can be used both external and internal and can treat from external and internal; when in internal use, the traditional Chinese medicine composition has the effects of clearing heat and cooling blood, removing toxicity for detumescence, strengthening Yang and relaxing bowels, cleaning blood and promoting metabolism, and cuts off a nutrient source of sarcoptic mites so that the foundation for the sarcoptic mite to attach to a swine body is removed; when in external use, the traditional Chinese medicine composition has the effects of disinfecting and disinsectizing, eliminating dampness and relieving itching, promoting tissue regeneration and repairing epidermal tissue, and can control the disease quickly; by adopting such combination, the best of each raw medicine is brought out, good effect of treating both symptoms and root causes is realized, and thus the swine mange and scab can be cured completely.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of Chinese medicine composition for the treatment of the pig mange and scab and preparation method thereof.
Background technology
The pig scabies is general and the most serious a kind of in the pig dermatosis, the pig scabies originate in usually head, near the eyes, buccal and ear, spread to back, side and strand inboard later on, multiple and degree is heavier with piglet especially.Sick pig performance play is itched, and friction everywhere is so that galling is hemorrhage, and affected part depilation, incrustation, pachyderma form gauffer and be full of cracks, loss of appetite, and growth retardation is become thin gradually, and serious caused depletion is dead.Primary disease is mainly in following pig of 5 monthly ages, and the above growth pig of 25kg mainly shows as cough and breathes, and partly have loose bowels symptom or respiratory symptom are arranged.The pig body is seen the erythema of the outstanding skin surface of many circles under the summer and autumn hot climate, and then obviously reduce or do not have winter.The large and small pig of this disease all can infect, and has a strong impact on the growth promoter of pig, brings enormous economic loss to pig industry.
At present, the medicine one of mainly treating the pig scabies on the market is with 2% metrifonate aqueous solution shampooing affected part or spray pig body; The 2nd, with ivermectin or subcutaneous injection of every kg body weight 0.3 gram of avilamycin, or 0.25% single first miaow, 2 spray pig bodies etc. weekly, but in fact these medicines are all undesirable to the therapeutic effect of pig scabies, be difficult to reach the purpose of thorough healing pig scabies, in addition, have drug safety wayward, influence meat quality, and medicine be difficult for to absorb, onset is slow, easy shortcomings such as recurrence.
Summary of the invention
Technical problem to be solved by this invention is at above-mentioned the deficiencies in the prior art, and a kind of Chinese medicine composition for the treatment of the pig mange and scab is provided.The inside and outside same usefulness of this Chinese medicine composition, inside and outside rule together, interior usefulness has clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling, plays supporing yang relieving constipation, cleaning blood, the effect that enhances metabolism has stoped the parasitic source of nutrition of acaricide, and has lost the basis that is attached to the pig body; External energy disinfection, dampness removing to stop itchin, the granulation promoting antiinflammatory, the effect of reparation epidermal tissue can be controlled the state of an illness rapidly, and this compatibility brings out the best in each other, and plays the good result for the treatment of both the principal and secondary aspects of a disease, thereby can thoroughly cure the pig mange and scab.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine composition for the treatment of the pig mange and scab, it is characterized in that, made by following bulk drugs: spend 700-1200 parts of the female dishes of pig in vain, 500-1000 parts of Cortex Dictamni, 300-800 parts of Radix Sophorae Flavescentiss, 300-800 parts of Fructus Cnidiis, 100-500 parts of sulfurs.
Above-mentioned a kind of Chinese medicine composition for the treatment of the pig mange and scab is made by following bulk drugs: spend 800-1100 parts of the female dishes of pig in vain, 600-700 parts of Cortex Dictamni, 400-600 parts of Radix Sophorae Flavescentiss, 400-600 parts of Fructus Cnidiis, 200-400 parts of sulfurs.
Above-mentioned a kind of Chinese medicine composition for the treatment of the pig mange and scab is made by following bulk drugs: spend 1000 parts of the female dishes of pig in vain, 700 parts of Cortex Dictamni, 500 parts of Radix Sophorae Flavescentiss, 500 parts of Fructus Cnidiis, 300 parts of sulfurs.
Above-mentioned a kind of Chinese medicine composition for the treatment of the pig mange and scab, the dosage form of described Chinese medicine composition is oral formulations or external preparation.
In addition, the present invention also provides the method for preparing above-mentioned Chinese medicine composition, it is characterized in that, this method may further comprise the steps:
Step 1, take by weighing and spend the female dish of pig, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain by weight, each medical material that takes by weighing is cleaned respectively;
Step 2, with the Fructus Cnidii after cleaning in step 1 crushing, the Cortex Dictamni after cleaning in the step 1 and Radix Sophorae Flavescentis are ground into 24 purpose coarse powder respectively;
Step 3, the sulfur water after cleaning in the step 1 is flown, 150 mesh sieves are crossed in the back of drying in the shade, and extracting screen underflow is standby;
Step 4, will spend the female dish cutting of pig in vain after cleaning in the step 1, soak then twice, each amount of water is 7～9 times that spend the female dish weight of pig in vain, each soaking temperature is 70 ℃～90 ℃, each soak time is 1h～3h, the soak that merges twice immersion, after the filtration, it is 3～5 times the concentrated medicament A that crude drug is spent the female dish weight of pig in vain that filtrate decompression is concentrated into weight;
Step 5, with the taper diffusiometer of packing into of the Fructus Cnidii after the coarse powder of Cortex Dictamni described in the step 2, Radix Sophorae Flavescentis coarse powder and the crushing, add mass percent concentration then in the diffusiometer and be soak with ethanol 10h～15h of 70%～75%, then the seepage speed of described taper diffusiometer is transferred to 4mL/min～5mL/min and carry out seepage, collect effusion, again the effusion of collecting is filtered, filtrate decompression is concentrated into 2～3 times the concentrated medicament B that weight is crude drug Cortex Dictamni, Radix Sophorae Flavescentis and Fructus Cnidii gross weight; The addition of described ethanol is crude drug Cortex Dictamni, Radix Sophorae Flavescentis and Fructus Cnidii gross weight 8～12 times;
Step 6, with concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in the step 3, the step 4 and the step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions, wherein equal portions are made oral formulations according to the method for conventional oral formulations, and other equal portions are made external preparation according to the method for conventional external preparation.
Above-mentioned method, the pressure of concentrating under reduced pressure described in the step 4 be-0.03MPa～-0.08MPa, temperature is 60 ℃～80 ℃.
Above-mentioned method, the pressure of concentrating under reduced pressure described in the step 5 be-0.03MPa～-0.08MPa, temperature is 60 ℃～80 ℃.
Described weight portion can be weight metering units such as gram, two, jin, kilogram, ton.
Spend the female dish of pig in vain and be the crawl herb of herbaceous plant Herba Bacopae monnieri of Scrophulariaceae, it is little sweet, light, cold in nature to distinguish the flavor of, spend the female dish Saponin A of pig and B main containing in vain, generate glucose, arabinose and spend the female dish ruscogenin of pig A1, A2, A3 and A4 in vain through acid hydrolysis, summer, autumn gather, cutting is dried, and has clearing away heat and cooling blood, the effect of removing toxic substances and promoting subsidence of swelling.Cortex Dictamni is the root bark of Rutaceae herbaceos perennial shaggy-fruited dittany and narrow leaf shaggy-fruited dittany, bitter in the mouth, salty, cold, return spleen channel, lung meridian, small intestine meridian, stomach warp, urinary bladder channel, the chemical constituent of Cortex Dictamni mainly contains dictamine, dictamnolactone, shaggy-fruited dittany brain lactide, Xi ketone, obacunone etc., wherein the pharmacological action of dictamine, Xi ketone, three kinds of compositions of obacunone can represent Cortex Dictamni and the effect in compound recipe thereof substantially, spring, Qiu Erji excavate root, remove silt and rough bark, strip root bark, section, drying is given birth to and is used, has heat clearing and damp drying, the effect of the detoxifying and relieving itching of dispeling the wind.Radix Sophorae Flavescentis is the root of the perennial semishrub plant's Radix Sophorae Flavescentis of falling leaves, and bitter in the mouth is cold in nature, return liver, kidney, large intestine, small intestine meridian, heart channel, urinary bladder channel, mainly contain matrine, oxymatrine, sophoridine, kurarinone, also contain Radix Sophorae Flavescentis saponin I, II, III, IV, soyasaponins I and quinones Radix Sophorae Flavescentis quinone A, kurarinones etc., annual spring and autumn are gathered into medicinal, has heat clearing and damp drying, wind dispelling insecticide, main treatment skin pruritus, blood tinea corporis skin ulcer, naughty white scales, pathogenic wind expelling, detumescence poison, expectorant poison, disease such as relieving asthma.Fructus Cnidii is samphire cnidium monnieri Cnidium monnieri(L.) dry mature fruit of Cuss., acrid in the mouth, hardship, warm in nature, return spleen channel, kidney channel, main component is pinene, camphene, different one-tenth acid borneol acetate, isoborneol, summer, two season of autumn gather during fruit maturation, remove impurity, dry, the tool warming the kidney to invigorate YANG, removing dampness and killing parasites, dispelling wind for relieving itching, the effect of relievining asthma.Sulfur is native element class mineral sulfur family sulphurite, after excavating, heat fused is removed impurity, or make through processing with containing sulfur mineral, sour in the mouth, warm in nature, return kidney, large intestine channel, the main elemental sulfur S8 that contains, small amount of calcium, ferrum, aluminum, magnesium and elements such as trace selenium, tellurium are still arranged, have the detoxifcation killing parasites for relieving itching, mend the effect of fiery supporing yang relieving constipation.The present invention is monarch drug to spend the female dish of pig and Cortex Dictamni in vain, be aided with monarch drug with Radix Sophorae Flavescentis, Fructus Cnidii, sulfur three flavor ministerial drugs and spend the female dish of pig, Cortex Dictamni in vain, inside and outside same usefulness, inside and outside rule together, and reach clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling, play supporing yang relieving constipation, cleaning blood, the merit that enhances metabolism, and realize disinfection, dampness removing to stop itchin, the granulation promoting antiinflammatory, the effect of reparation epidermal tissue is controlled the state of an illness rapidly.
The usage and dosage of Chinese medicine composition of the present invention:
1, oral solutions usage and dosage: oral, by the each 1.5mL/kg of pig body weight, every day 3 times;
2, granular preparation usage and dosage: oral, by the each 0.5g/kg of pig body weight, every day 3 times;
3, pill usage and dosage: oral, by the each 0.5g/kg of pig body weight, every day 3 times;
4, tablet usage and dosage: oral, by the each 0.5g/kg of pig body weight, every day 3 times;
5, spray usage and dosage: external, each time spent shakes up and is sprayed at Corii Sus domestica skin surface and pig house, by the each 2.0mL/kg of pig body weight, every day 3 times;
6, ointment usage and dosage: external, evenly be applied in Corii Sus domestica skin surface, by the each 0.5g/kg of pig body weight, every day 3 times;
7, gel usage and dosage: external, evenly be applied in Corii Sus domestica skin surface, by the each 0.5g/kg of pig body weight, every day 3 times.
The present invention compared with prior art has the following advantages:
1, the invention belongs to pure Chinese medicinal preparation, other internal organs are had no side effect treating both the principal and secondary aspects of a disease.
2, Chinese medicine composition of the present invention does not have specific peculiar smell, and large and small pig is all suitable, takes safety, and good the absorption easily preserved, and can guarantee the quality 2 years.
3, the inside and outside same usefulness of Chinese medicine composition of the present invention, inside and outside rule together, interior usefulness has clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling, plays supporing yang relieving constipation, cleaning blood, the effect that enhances metabolism has stoped the parasitic source of nutrition of acaricide, and has lost the basis that is attached to the pig body; External energy disinfection, dampness removing to stop itchin, the granulation promoting antiinflammatory, the effect of reparation epidermal tissue can be controlled the state of an illness rapidly, and this compatibility brings out the best in each other, and plays the good result for the treatment of both the principal and secondary aspects of a disease, thereby can thoroughly cure the pig mange and scab.
4, Chinese medicine composition composition formula uniqueness of the present invention, cure rate height, safe, relapse rate is low, stability is strong, have no side effect, treating both the principal and secondary aspects of a disease, suffer from pig with after do not develop complications, untoward reaction such as recurrence, be fit to medicine listing popularization.
Below by embodiment, technical scheme of the present invention is described in further detail.
The specific embodiment
Embodiment 1
The Chinese medicine composition of present embodiment is made by following crude drug: spend the female dish 1000g of pig in vain, Cortex Dictamni 700g, Radix Sophorae Flavescentis 500g, Fructus Cnidii 500g, sulfur 300g.
The Chinese medicine composition dosage form of present embodiment is oral solutions and spray.
The preparation method of the Chinese medicine composition of present embodiment is:
Step 1, take by weighing by prescription and to spend the female dish of pig, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain, each medical material that takes by weighing is cleaned respectively;
Step 2, with the Fructus Cnidii after cleaning in step 1 crushing, the Cortex Dictamni after cleaning in the step 1 and Radix Sophorae Flavescentis are ground into 24 purpose coarse powder respectively;
Step 3, the sulfur water after cleaning in the step 1 is flown to impalpable powder, 150 mesh sieves are crossed in the back of drying in the shade, and extracting screen underflow is standby;
Step 4, will spend the female dish cutting of pig in vain after cleaning in the step 1, soak then twice, each amount of water is 8 times that spend the female dish weight of pig in vain, each soaking temperature is 80 ℃, each soak time is 2h, the soak that merges twice immersion after the filtration, is concentrated into the concentrated medicament A that weight is 4000g with filtrate decompression; The pressure of described concentrating under reduced pressure is-0.05MPa that temperature is 70 ℃;
Step 5, with the taper diffusiometer of packing into of the Fructus Cnidii after the coarse powder of Cortex Dictamni described in the step 2, Radix Sophorae Flavescentis coarse powder and the crushing, add the 17kg mass percent concentration then in the diffusiometer and be 70% soak with ethanol 12h, then the seepage speed of described taper diffusiometer is transferred to 4.5mL/min and carry out seepage, collect effusion, again the effusion of collecting is filtered, filtrate decompression is concentrated into the concentrated medicament B that weight is 4000g; The pressure of described concentrating under reduced pressure is-0.05MPa that temperature is 70 ℃;
Step 6, with concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in the step 3, the step 4 and the step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions; To wherein adding 300mL Tween 80 and 100g sodium benzoate, the oral liquid of the pig mange and scab that obtains medical treatment behind the mix homogeneously in the equal portions; In other equal portions, add 300mL Tween 80,100g sodium benzoate and 300mL dimethyl sulfoxide, the spray of the pig mange and scab that obtains medical treatment behind the mix homogeneously.
Embodiment 2
The Chinese medicine composition of present embodiment is made by following crude drug: spend the female dish 1200kg of pig in vain, Cortex Dictamni 500kg, Radix Sophorae Flavescentis 300kg, Fructus Cnidii 800kg, sulfur 100kg.
The Chinese medicine composition dosage form of present embodiment is granule and ointment.
The preparation method of the Chinese medicine composition of present embodiment is:
Step 1, take by weighing by prescription and to spend the female dish of pig, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain, each medical material that takes by weighing is cleaned respectively;
Step 2, with the Fructus Cnidii after cleaning in step 1 crushing, the Cortex Dictamni after cleaning in the step 1 and Radix Sophorae Flavescentis are ground into 24 purpose coarse powder respectively;
Step 3, the sulfur water after cleaning in the step 1 is flown to impalpable powder, 150 mesh sieves are crossed in the back of drying in the shade, and extracting screen underflow is standby;
Step 4, will spend the female dish cutting of pig in vain after cleaning in the step 1, soak then twice, each amount of water is 9 times that spend the female dish weight of pig in vain, each soaking temperature is 90 ℃, each soak time is 1h, the soak that merges twice immersion after the filtration, is concentrated into the concentrated medicament A that weight is 3600kg with filtrate decompression; The pressure of described concentrating under reduced pressure is-0.03MPa that temperature is 80 ℃;
Step 5, with the taper diffusiometer of packing into of the Fructus Cnidii after the coarse powder of Cortex Dictamni described in the step 2, Radix Sophorae Flavescentis coarse powder and the crushing, add the 12800kg mass percent concentration then in the diffusiometer and be 75% soak with ethanol 10h, then the seepage speed of described taper diffusiometer is transferred to 4mL/min and carry out seepage, collect effusion, again the effusion of collecting is filtered, filtrate decompression is concentrated into the concentrated medicament B that weight is 4800kg; The pressure of described concentrating under reduced pressure is-0.03MPa that temperature is 60 ℃;
Step 6, with concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in the step 3, the step 4 and the step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions; With equal portions wherein routinely the method for granule processed make granule, pack, every bag is equivalent to crude drug 20g; With another equal portions routinely the method for ointment processed make ointment, tubulature, every pipe 100g, every pipe is equivalent to crude drug 100g.
Embodiment 3
The Chinese medicine composition of present embodiment is made by following crude drug: spend the female dish 700g of pig in vain, Cortex Dictamni 1000g, Radix Sophorae Flavescentis 800g, Fructus Cnidii 300g, sulfur 500g.
The Chinese medicine composition dosage form of present embodiment is pill and ointment.
The preparation method of the Chinese medicine composition of present embodiment is:
Step 1, take by weighing by prescription and to spend the female dish of pig, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain, each medical material that takes by weighing is cleaned respectively;
Step 2, with the Fructus Cnidii after cleaning in step 1 crushing, the Cortex Dictamni after cleaning in the step 1 and Radix Sophorae Flavescentis are ground into 24 purpose coarse powder respectively;
Step 3, the sulfur water after cleaning in the step 1 is flown to impalpable powder, 150 mesh sieves are crossed in the back of drying in the shade, and extracting screen underflow is standby;
Step 4, will spend the female dish cutting of pig in vain after cleaning in the step 1, soak then twice, each amount of water is 7 times that spend the female dish weight of pig in vain, each soaking temperature is 70 ℃, each soak time is 3h, the soak that merges twice immersion after the filtration, is concentrated into the concentrated medicament A that weight is 3500g with filtrate decompression; The pressure of described concentrating under reduced pressure is-0.08MPa that temperature is 70 ℃;
Step 5, with the taper diffusiometer of packing into of the Fructus Cnidii after the coarse powder of Cortex Dictamni described in the step 2, Radix Sophorae Flavescentis coarse powder and the crushing, add the 25.2kg mass percent concentration then in the diffusiometer and be 73% soak with ethanol 15h, then the seepage speed of described taper diffusiometer is transferred to 5mL/min and carry out seepage, collect effusion, again the effusion of collecting is filtered, filtrate decompression is concentrated into the concentrated medicament B that weight is 4200g; The pressure of described concentrating under reduced pressure is-0.08MPa that temperature is 70 ℃;
Step 6, with concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in the step 3, the step 4 and the step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions; With equal portions wherein routinely the method for pill agent make pill, every ball is equivalent to crude drug 10g; With another equal portions routinely the method for ointment processed make ointment, tubulature, every pipe 100g, every pipe is equivalent to crude drug 100g.
Embodiment 4
The Chinese medicine composition of present embodiment is made by following crude drug: spend the female dish 800kg of pig in vain, Cortex Dictamni 700kg, Radix Sophorae Flavescentis 400kg, Fructus Cnidii 400kg, sulfur 200kg.
The Chinese medicine composition dosage form of present embodiment is oral solutions and spray.
The preparation method of the Chinese medicine composition of present embodiment is:
Step 1, take by weighing by prescription and to spend the female dish of pig, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain, each medical material that takes by weighing is cleaned respectively;
Step 2, with the Fructus Cnidii after cleaning in step 1 crushing, the Cortex Dictamni after cleaning in the step 1 and Radix Sophorae Flavescentis are ground into 24 purpose coarse powder respectively;
Step 3, the sulfur water after cleaning in the step 1 is flown to impalpable powder, 150 mesh sieves are crossed in the back of drying in the shade, and extracting screen underflow is standby;
Step 4, will spend the female dish cutting of pig in vain after cleaning in the step 1, soak then twice, each amount of water is 7 times that spend the female dish weight of pig in vain, each soaking temperature is 90 ℃, soak for the first time 2h, soak 3h for the second time, merge the soak of twice immersion, after the filtration, filtrate decompression is concentrated into the concentrated medicament A that weight is 4000kg; The pressure of described concentrating under reduced pressure is-0.05MPa that temperature is 80 ℃;
Step 5, with the taper diffusiometer of packing into of the Fructus Cnidii after the coarse powder of Cortex Dictamni described in the step 2, Radix Sophorae Flavescentis coarse powder and the crushing, add the 15000kg mass percent concentration then in the diffusiometer and be 70% soak with ethanol 13h, then the seepage speed of described taper diffusiometer is transferred to 4mL/min and carry out seepage, collect effusion, again the effusion of collecting is filtered, filtrate decompression is concentrated into the concentrated medicament B that weight is 3000kg; The pressure of described concentrating under reduced pressure is-0.08MPa that temperature is 70 ℃;
Step 6, with concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in the step 3, the step 4 and the step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions; To wherein adding 300L Tween 80 and 100kg sodium benzoate, the oral liquid of the pig mange and scab that obtains medical treatment behind the mix homogeneously in the equal portions; In another equal portions, add 300L Tween 80,100kg sodium benzoate and 300L dimethyl sulfoxide, the spray of the pig mange and scab that obtains medical treatment behind the mix homogeneously.
Embodiment 5
The Chinese medicine composition of present embodiment is made by following crude drug: spend the female dish 1100g of pig in vain, Cortex Dictamni 600g, Radix Sophorae Flavescentis 600g, Fructus Cnidii 600g, sulfur 400g.
The Chinese medicine composition dosage form of present embodiment is tablet and gel.
The preparation method of the Chinese medicine composition of present embodiment is:
Step 1, take by weighing by prescription and to spend the female dish of pig, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain, each medical material that takes by weighing is cleaned respectively;
Step 2, with the Fructus Cnidii after cleaning in step 1 crushing, the Cortex Dictamni after cleaning in the step 1 and Radix Sophorae Flavescentis are ground into 24 purpose coarse powder respectively;
Step 3, the sulfur water after cleaning in the step 1 is flown to impalpable powder, 150 mesh sieves are crossed in the back of drying in the shade, and extracting screen underflow is standby;
Step 4, will spend the female dish cutting of pig in vain after cleaning in the step 1, soak then twice, each amount of water is 8 times that spend the female dish weight of pig in vain, each soaking temperature is 80 ℃, soak for the first time 3h, soak 2h for the second time, merge the soak of twice immersion, after the filtration, filtrate decompression is concentrated into the concentrated medicament A that weight is 5000g; The pressure of described concentrating under reduced pressure is-0.03MPa that temperature is 60 ℃;
Step 5, with the taper diffusiometer of packing into of the Fructus Cnidii after the coarse powder of Cortex Dictamni described in the step 2, Radix Sophorae Flavescentis coarse powder and the crushing, add the 21.6kg mass percent concentration then in the diffusiometer and be 75% soak with ethanol 10h, then the seepage speed of described taper diffusiometer is transferred to 5mL/min and carry out seepage, collect effusion, again the effusion of collecting is filtered, filtrate decompression is concentrated into the concentrated medicament B that weight is 4500g; The pressure of described concentrating under reduced pressure is-0.05MPa that temperature is 80 ℃;
Step 6, with concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in the step 3, the step 4 and the step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions; With equal portions wherein routinely the method for film-making agent make tablet, every is equivalent to crude drug 1g; With another equal portions routinely the method for gel processed make gel, tubulature, every pipe is equivalent to crude drug 100g.
The usage and dosage of Chinese medicine composition of the present invention:
1, oral solutions usage and dosage: oral, by the each 1.5mL/kg of pig body weight, every day 3 times;
2, granular preparation usage and dosage: oral, by the each 0.5g/kg of pig body weight, every day 3 times;
3, pill usage and dosage: oral, by the each 0.5g/kg of pig body weight, every day 3 times;
4, tablet usage and dosage: oral, by the each 0.5g/kg of pig body weight, every day 3 times;
5, spray usage and dosage: external, each time spent shakes up and is sprayed at Corii Sus domestica skin surface and pig house, by the each 2.0mL/kg of pig body weight, every day 3 times;
6, ointment usage and dosage: external, evenly be applied in Corii Sus domestica skin surface, by the each 0.5g/kg of pig body weight, every day 3 times;
7, gel usage and dosage: external, evenly be applied in Corii Sus domestica skin surface, by the each 0.5g/kg of pig body weight, every day 3 times.
The diagnostic criteria of pig mange and scab curative effect:
Criterion of cure: the complete obiteration of pig mange and scab symptom, no any discomfort is not seen recurrence.
The produce effects standard: erubescence, serosity soak into transference cure, the cough of growth pig and breathe, transference cure is itched in play.
Effective standard: symptom obviously alleviates, and idol has cough and breathes or slightly itch disease.
Invalid standard: symptom, sign do not have obvious change.
General clinical data: clinical observation case of the present invention is totally 110 examples, and in 1.5 months to 5 months age of pig, wherein boar is 58,52 of sows, and medical history is suffered from pigs with 110 examples and is divided into two groups at random all more than 1 month, and 60 examples are organized in treatment, matched group 50 examples.The treatment group is for oral administration and external oral solutions of the present invention and spray simultaneously.Oral solutions is for oral administration, each and pig feed mix homogeneously, and consumption is by pig body weight 1.5mL/kg, every day 3 times; Spray is external, and each time spent shakes up and is sprayed at Corii Sus domestica skin surface and pig house, and consumption every day 3 times, 5 days courses for the treatment of, uses two courses for the treatment of by pig body weight 2.0mL/kg; 25 examples remain 25 examples with subcutaneous injection of every kg body weight 0.3 gram of ivermectin with 2% metrifonate aqueous solution shampooing affected part or spray pig body in the matched group in the matched group, 5 days courses for the treatment of, use two courses for the treatment of.
Table 1 clinical efficacy result relatively
Clinical observation case of the present invention is totally 110 examples, and in 1.5 months to 5 months age of pig, wherein boar is 58,52 of sows, and medical history is suffered from pigs with 110 examples and is divided into two groups at random all more than 1 month, and 60 examples are organized in treatment, matched group 50 examples.The treatment group is for oral administration and external oral solutions of the present invention and spray simultaneously.Oral solutions is for oral administration, each and pig feed mix homogeneously, and consumption is by pig body weight 1.5mL/kg, every day 3 times; Spray is external, and each time spent shakes up and is sprayed at Corii Sus domestica skin surface and pig house, and consumption every day 3 times, 5 days courses for the treatment of, uses two courses for the treatment of by pig body weight 2.0mL/kg; 25 examples remain 25 examples with subcutaneous injection of every kg body weight 0.3 gram of ivermectin with 2% metrifonate aqueous solution shampooing affected part or spray pig body in the matched group in the matched group, 5 days courses for the treatment of, use two courses for the treatment of.Treatment group and matched group general curative effect compare, and its result organizes 60 routine oral oral liquids of the present invention for treatment, and external spray of the present invention, cures 48 examples, accounts for 80%, and produce effects 9 examples account for 15%, and effective 3 examples account for 5%, total effective rate 100%.Matched group 25 examples are cured 9 examples with 2% metrifonate aqueous solution, account for 36%, and produce effects 7 examples account for 28%, and effective 3 examples account for 12%, and invalid 6 examples account for 24%, total effective rate 76%; Other 25 examples of matched group are cured 8 examples with subcutaneous injection of every kg body weight 0.3 gram of ivermectin, account for 32%, and produce effects 8 examples account for 32%, and effective 2 examples account for 8%, and invalid 7 examples account for 28%, total effective rate 72%; Mostly that cures in the matched group is slightly to suffer from pig, and recurrence easily in the therapeutic process, treatment group and matched group relatively curative effect there were significant differences.Chinese medicine composition composition formula uniqueness of the present invention, cure rate height, safe, relapse rate is low, stability is strong, have no side effect, treating both the principal and secondary aspects of a disease, suffer from pig with after do not develop complications, untoward reaction such as recurrence, be fit to medicine listing popularization.
Model case
Case 1
White pig is hybridized at the two that family Wu feeds of raising pigs in lawn, town, lawn, Zuoshui County village, and body weight is respectively 27kg and 30kg.All suffering from the pig mange and scab in late March, 2010, is that neck, back and belly portion infect at first, after be extended down to whole body, pars affecta skin thickens, and wrinkle is arranged, sick pig feed desire is depressed, becomes thin, and very itches, the circle interior walls of being everlasting friction, some places have galled hemorrhage, and serious scar is arranged.Through the each and pig feed mix homogeneously with Chinese medicine composition oral solutions of the present invention, consumption is by pig body weight 1.5mL/kg, every day 3 times; Each time spent of externally applied spray shakes up and is sprayed at Corii Sus domestica skin surface and pig house, and consumption is by pig body weight 2.0mL/kg, and every day 3 times, for oral administration and external is used simultaneously, is used in conjunction 5 days, and it is normal that pars affecta skin recovers.Continue again later on to use 4 days, all cure, not morbidity again.
Case 2
Jin Tai village, tile-roofed house mouth town, Zuoshui County certain 9 pig raising with circle of family gold of raising pigs, every body weight is about 23kg, in in late April, 2011, discovery has a pig cervical region and back that the pig scabies takes place, and suffers from violent wiping of pig and itches, and other 8 are also infected in succession after 9 days, wherein have 2 more serious, through the each and pig feed mix homogeneously with Chinese medicine composition oral solutions of the present invention, consumption is by pig body weight 1.5mL/kg, every day 3 times; Each time spent of externally applied spray shakes up and is sprayed at Corii Sus domestica skin surface and pig house, and consumption is by pig body weight 2.0mL/kg, and every day 3 times, for oral administration and external is used simultaneously, is used in conjunction 5 days, and it is normal that pars affecta skin recovers.Continue again later on to use 5 days, all cure, not morbidity again.
Case 3
Jin Long village, tile-roofed house mouth town, the Zuoshui County family Wang that raises pigs has raised 5 black hybridization breeding pigs with circle, every body weight is about 26kg, begin in mid-April, 2012, find that every pig has the situation of itching in the wiping of colony house wall in various degree, this situation was more violent in 6 days subsequently, and at cervical region and the back of pig pimple appears gradually, vesicle, incrustation depilation behind the ulceration, also show as fervescence simultaneously, the general skin rubefaction has yellowish-brown fat exudate, smell foul smell, through the each and pig feed mix homogeneously with Chinese medicine composition oral solutions of the present invention, consumption is by pig body weight 1.5mL/kg, every day 3 times; Each time spent of externally applied spray shakes up and is sprayed at Corii Sus domestica skin surface and pig house, and consumption is by pig body weight 2.0mL/kg, and every day 3 times, for oral administration and external is used simultaneously, is used in conjunction 5 days, and it is normal that pars affecta skin recovers.Continue again later on to use 5 days, all cure, not morbidity again.
Case 4
After a collection of replacement gilt is newly advanced in May, 2011 in bright moon live pig breeding breeding farm, tile-roofed house mouth town, Zuoshui County, except piglet in more than 30 days 10 ages in days does not see the manifest symptom, all the other 63 each in stage pig all suffer from the pig mange and scab, sickness rate 90%.Through inquiry, the main reflection of poultry says that most of sick piglet has bad physiques, dysplasia, and spirit is depressed.Check the main disease piglet that takes of poultry, mainly be chafing, depilation, very itch, hemorrhage, be the eczema sexually transmitted disease (STD) and become, have body constitution comparatively good piglet mouth, eyes, ear surrounding skin rubescent, pimple, vesicle appear, form a scab behind the ulceration and lose hair or feathers.The Low piglet in two also shows as fervescence except above-mentioned symptom is arranged in addition, and the general skin rubefaction has yellowish-brown fat exudate, smells foul smell, and epidermis thickens, and drying is chapped.Through the each and pig feed mix homogeneously with Chinese medicine composition oral solutions of the present invention, consumption is by pig body weight 1.5mL/kg, every day 3 times; Each time spent of externally applied spray shakes up and is sprayed at Corii Sus domestica skin surface and pig house, and consumption is by pig body weight 2.0mL/kg, and every day 3 times, for oral administration and external is used simultaneously, and after half day, gargalesthesia subtracts greatly; Treat after 2 days, it is antipruritic no longer to rub, and is used in conjunction 5 days, and it is normal that pars affecta skin recovers.Continue again later on to use 5 days, all cure, not morbidity again.
Claims (7)
1. a Chinese medicine composition for the treatment of the pig mange and scab is characterized in that, is made by following bulk drugs: spend 700-1200 parts of the female dishes of pig in vain, 500-1000 parts of Cortex Dictamni, 300-800 parts of Radix Sophorae Flavescentiss, 300-800 parts of Fructus Cnidiis, 100-500 parts of sulfurs.
2. a kind of Chinese medicine composition for the treatment of the pig mange and scab according to claim 1 is characterized in that, is made by following bulk drugs: spend 800-1100 parts of the female dishes of pig in vain, 600-700 parts of Cortex Dictamni, 400-600 parts of Radix Sophorae Flavescentiss, 400-600 parts of Fructus Cnidiis, 200-400 parts of sulfurs.
3. a kind of Chinese medicine composition for the treatment of the pig mange and scab according to claim 2 is characterized in that, is made by following bulk drugs: spend 1000 parts of the female dishes of pig in vain, 700 parts of Cortex Dictamni, 500 parts of Radix Sophorae Flavescentiss, 500 parts of Fructus Cnidiis, 300 parts of sulfurs.
4. according to claim 1,2 or 3 described a kind of Chinese medicine compositions for the treatment of the pig mange and scab, it is characterized in that the dosage form of described Chinese medicine composition is oral formulations or external preparation.
5. method for preparing as Chinese medicine composition as described in the claim 1,2 or 3 is characterized in that this method may further comprise the steps:
Step 1, take by weighing and spend the female dish of pig, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Cnidii and sulfur in vain by weight, each medical material that takes by weighing is cleaned respectively;
Step 2, with the Fructus Cnidii after cleaning in step 1 crushing, the Cortex Dictamni after cleaning in the step 1 and Radix Sophorae Flavescentis are ground into 24 purpose coarse powder respectively;
Step 3, the sulfur water after cleaning in the step 1 is flown, 150 mesh sieves are crossed in the back of drying in the shade, and extracting screen underflow is standby;
Step 4, will spend the female dish cutting of pig in vain after cleaning in the step 1, soak then twice, each amount of water is 7～9 times that spend the female dish weight of pig in vain, each soaking temperature is 70 ℃～90 ℃, each soak time is 1h～3h, the soak that merges twice immersion, after the filtration, it is 3～5 times the concentrated medicament A that crude drug is spent the female dish weight of pig in vain that filtrate decompression is concentrated into weight;
Step 5, with the taper diffusiometer of packing into of the Fructus Cnidii after the coarse powder of Cortex Dictamni described in the step 2, Radix Sophorae Flavescentis coarse powder and the crushing, add mass percent concentration then in the diffusiometer and be soak with ethanol 10h～15h of 70%～75%, then the seepage speed of described taper diffusiometer is transferred to 4mL/min～5mL/min and carry out seepage, collect effusion, again the effusion of collecting is filtered, filtrate decompression is concentrated into 2～3 times the concentrated medicament B that weight is crude drug Cortex Dictamni, Radix Sophorae Flavescentis and Fructus Cnidii gross weight; The addition of described ethanol is crude drug Cortex Dictamni, Radix Sophorae Flavescentis and Fructus Cnidii gross weight 8～12 times;
Step 6, with concentrated medicament B mix homogeneously described in concentrated medicament A described in siftage described in the step 3, the step 4 and the step 5, obtain admixing medical solutions, described admixing medical solutions is divided into two equal portions, wherein equal portions are made oral formulations according to the method for conventional oral formulations, and other equal portions are made external preparation according to the method for conventional external preparation.
6. method according to claim 5 is characterized in that, the pressure of concentrating under reduced pressure described in the step 4 is-and 0.03MPa～-0.08MPa, temperature is 60 ℃～80 ℃.
7. method according to claim 5 is characterized in that, the pressure of concentrating under reduced pressure described in the step 5 is-and 0.03MPa～-0.08MPa, temperature is 60 ℃～80 ℃.
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| CN109125654A (en) * | 2018-10-26 | 2019-01-04 | 申亚农牧科技股份有限公司 | It is a kind of for treating the Chinese traditional medicine composition liquid and preparation method of pig mustard tinea |
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