KR20080091052A - Cosmetic composition for having anti-atopic dermatitis effects containing natural product extracts - Google Patents

Abstract

A cosmetic composition comprising an extract of at least one natural material is provided to be more environment-friendly and lower-toxic than a cosmetic composition comprising chemical synthetic ingredients and improve symptoms of atopic dermatitis excellently. A cosmetic composition having anti-atopic dermatitis effect comprises 0.01-10 wt.% of an extract of at least one natural material selected from the group consisting of Metaplexis japonica leaves, green tea seeds, Astragalus membranaceus, Taraxacum platycarpum, Agaricus blazei Murill, Gynostemma pentaphyllum, Umbilicaria esculenta and Camellia japonica pericarps as an effective ingredient.

Description

Cosmetic composition having anti-atopic dermatitis effect by containing extract of natural product

The present invention relates to a cosmetic composition for improving skin condition containing a natural product as an active ingredient and excellent anti-atopic effect. More specifically, the present invention relates to a cosmetic composition containing an extract of leaves such as gourds, green tea seeds, astragalus, dandelion, agaricus, dol, seokki or camellia skin as an active ingredient.

Skin disease refers to abnormalities on all skin including hair, nails and toenails of mammals including humans, and atopic dermatitis, which occurs in people with atopic allergies, is a representative disease.

Although the cause of atopic dermatitis has not been clearly identified, it is called by allergic people, and is understood as one of genetic factors or immune diseases, especially with allergic rhinitis and asthma. The disease is characterized by the initial severe itching, which is most likely to be aggravated by scratching the skin and subsequent secondary infections, especially the patient's mental stability and emotional state.

Atopic dermatitis suffers from a significant number of people, with 0.5 to 1 percent of the population and 5 to 10 percent of children. The onset of symptoms usually occurs within two to six months of age, especially in infants under one year of age, with 85% occurring within five years of age. Atopic dermatitis mainly occurs in infancy, but recently, the number of patients after puberty is increasing, and the history is very long. In the treatment of atopic dermatitis, drugs such as corticosteroids, which can expect high pharmacological effects, are used. However, such side effects of corticosteroids are problematic and patients are exposed to the risk of side effects during treatment. Moreover, it is also well known that rebounding (acute disease lesions that occur after the drug is suspended) is caused by discontinuation of the corticosteroids. As a countermeasure for such side effects, nonsteroidal anti-inflammatory agents or antihistamines, which do not contain hormones such as corticosteroids, are used, but they are difficult to cure. Therefore, there is a very urgent need to reduce or treat atopic dermatitis without side effects.

Accordingly, the present inventors have studied to find a natural product with low toxicity and low toxicity while improving the symptoms of atopic dermatitis. As a result, anti-atopic dermatitis on extracts of green leaves, green tea seeds, Astragalus, dandelion, agaricus, dodol, stone or camellia It has been found to be effective and the present invention has been completed.

Accordingly, an object of the present invention is to provide a cosmetic composition excellent in anti-atopic effect by using a natural product.

In order to achieve the above object, the present invention provides a cosmetic composition for anti-atopic skin containing at least one extract selected from the group consisting of gourd leaf, green tea seed, Astragalus, dandelion, agaricus, dodol, stone and camellia skin as an active ingredient. to provide.

Improves the symptoms of atopic dermatitis by providing a cosmetic composition containing natural products such as green leaves, green tea seeds, astragalus, dandelion, agaricus, dolan, stone or camellia skin as active ingredients. The effect of making it excellent can provide a cosmetic composition.

In the present invention, it contains one or more extracts selected from the group consisting of gourd green leaf, green tea seeds, Astragalus, dandelion, agaricus, dol, seokki and camellia skin as an active ingredient, provides a cosmetic composition excellent in anti-atopic effect.

Hereinafter, the present invention will be described in more detail.

Park Ju-Gi is a vine grass with several oysters belonging to the genus Gam-Gi-O-Gi. The leaves are opposite each other, long egg flower heart-shaped, and the back is white green. In July-August, peduncles extend higher than the leaves and light purple flowers bloom. The flower bill is deeply divided into 5 pieces with dense hairs inside the cracked pieces. The leaves are opposite, long oval heart-shaped, and the back is white green. In July-August, peduncles extend higher than the leaves and light purple flowers bloom. The flower bill is deeply divided into 5 pieces with dense hairs inside the cracked piece. Fruits are broad, lanceolate, large, with projections on the surface, with long white hairs on the seeds. Seeds and leaves are dried and medicated. Seed hair has been used as a substitute for cotton. Most of the genus is a panicle, and the petals are shorter than the flower stamens and have long horn-shaped protrusions on the pistil. Distributed from temperate to subtropical in East Asia. White latex contains toxic components and is a mild sterling silver herb. Leaves and fruits are medicinal for tonic, tonic and detoxification. Seed hair is used to make stamp rice and needle wrap instead of cotton. It is distributed in Korea, Japan, and China.

Green tea is a favorite food containing unique fragrances such as caffeine, theanine, and tannin and a large amount of vitamins, and is also widely used as a health drink to help improve health. In addition, it is a food containing a large amount of flavonoids, which contains purine base, catechins, and various other ingredients. Therefore, it suppresses cancer cell proliferation, lowers blood pressure, lowers cholesterol, inhibits platelet aggregation, and blood sugar. There are many health benefits such as synergistic inhibitory effect, fatty liver inhibitory effect, antibacterial effect, intestinal useful bacterial growth promotion effect, neovascularization inhibitory effect and whitening effect, and green tea is added to foods to take advantage of the various effects of green tea. Many studies are being conducted to derive the unique taste or aroma of green tea.

Hwanggi is a perennial herb of dicotyledonous plant Rosaceae, grows in the crack of mountainous area, is 40 ~ 70cm high and has white soft hairs. Stems are gross and the leaves are odd one-time quills consisting of 6-11 pairs of small leaves, and small leaves are 1 ~ 2cm long, oval-shaped, and leaf edges are flat. Chin leaf is lanceolate with long pointed tip, long stem of flower stem from leaf axilla, with 5-10 flowers. Yellow-white flowers bloom in July-August, about 2cm long, small peduncle is about 3mm long. Calyx is about 5mm long, dark brown hairs are divided into 5 pieces. There are 10 stamens and fruits are fruited in November. The pod is long oval, pointed at both ends, length is 2-3cm, and contains 5-7 seeds. It is distributed in Korea, Japan, Manchuria, northeastern China, and eastern Siberia, and is commonly grown as a herb, and is harvested in autumn in oriental medicine to remove outcrops and fine roots, and dried in sunlight. (止汗), diuresis, swelling (효능) and so on, such as physical weakness, fatigue boredom, blood vessel collapse (허), prolapse, uterine dislocation, visceral sewage, cold sweat, peripheral nerves, etc. Prescribe.

Dandelion is the herbal name of Pogongyoung (浦 公 英, Taraxam). coreanum , Compositae ), a perennial herb of the Asteraceae. Commonly called dandelion (dandelion), the entire plant, such as roots, leaves, flowers, stalks are used for medicinal purposes. The scientific name Taraxacum is known to have effects on the liver, gallbladder, and kidney as shown by the compound words of taraxis (anxiety) and aceomi (treatment). In Korea, it is divided into T. hallaisanense , T. ohwianum , T. coreanum , T. officinale , and short domestic species . Indigenous dandelion in Korea takes several years to grow after flowering and blooms in spring, and it is difficult to use because it is not self-fertilizing. Dandelion that we see a lot around us is a naturalized plant, many of which are T. officinale and have strong vitality and breeding ability, so it can be collected and cultivated all year round, and the roots are straight, thick, and 10 to 15 days old. It can be re-harvested, making it a very economical plant and especially effective for soaking kimchi. In addition, there is no limit to its use as it is recognized as GRAS (generally recognized as safe) grade 10 in the US. Its main ingredients are rich in vitamins and minerals, low in fat and calories, and are suitable for well-being foods.It is rich in high-flavored taraxin, inulin, and carotenoid, taraxanthin taraxathin, taraxerol, a triterpene, taraxasterol, β-sitisterol, caffeic acid, taraxacine, etc. It is rich in C, tocopherol, Ca, Fe and K. The leaves have a diuretic that does not cause hypokalemia, and the high-flavored ingredients stimulate the digestive tract to help digestion, improve liver function of taurine, and promote bile secretion to enhance digestion of fat. In addition, it is used for hepatitis in oriental medicine, and in addition to detoxification, diuresis, and lactation, it also lowers heat, releases wool, and reduces inflammation. Viii) used. In Europe, the leaves are used as salads and the flowers are used to soak alcohol.

Dandelion's physiological activities include anti-oxidative activity, hydroxyl radical scavenging activity, antibacterial activity against food poisoning bacteria, antibacterial activity against inflammatory staphylococci and skin fungi. Kimchi fermented strains have been reported to have no effect. In addition, hot water extracts are known to have excellent antitumor effects, and have strong anticancer activity against sarcoma 180 (sarcoma 180) solid cancer. In addition, it is known to have an effect of improving lipid metabolism and anti-inflammatory effects in the body.

Agaricus is known as the aging mushroom and is known to have antitumor effect against various cancers, cancer cell proliferation inhibitory effect, cancer prevention effect, hypoglycemic effect, blood pressure lowering effect, cholesterol lowering effect, and arteriosclerosis. In addition, the inhibition rate for cancer cells has been confirmed to be 70% or more, and it has effects such as enhancing emollience and intestinal peristalsis, strengthening the active exercise of pulmonary function, and anti-cancer that can have a significant pharmacological effect on hypertension caused by diabetes. It is medicine.

Dol-eo is a perennial vine plant of the dicotyledonous plant, Pak pak. The rhizome stretches sideways and has white hairs on the nodes and grows tangled, but it also crawls up with tendrils. The leaves are alternate, 5-leafed, double-leafed, narrow egg-shaped oval or narrow egg-shaped. The small leaf at the end is 4-8cm long and 2 ~ 3cm long with small petioles. The tip is sharp and there are fine hairs on the front leaf veins, and the edge is serrated. A pale yellow-green flower blooms in August-September. It is biphasic and forms a conical inflorescence. Calyxes are extremely small and corollas are divided into 5, and the fragments are about 3mm long and are basso shaped. Fruits are berry, round, 6-8mm in diameter, ripen black and green, and seeds are 4mm long. It is distributed in Jeju, Gyeongsangbuk-do (Ulleungdo), Taiwan, China, India, and Malaysia.

Seok-yi is a kind of lichen that belongs to Seok-yi and Seok-yi. It is a leafy leaf growing on the rocks of a deep mountain. The lichen is 3 ~ 10cm in diameter (sometimes 30cm) in broad monologues, almost circular and leathery. When dried, it is dried upwards. The surface is yellowish brown or brown with a glossy, flat and sometimes exposed white water layer that drops off into spots. The back side is blackish brown or black, with fine granular projections, whole black, and dense short haired roots. It dries hard, but when immersed in water, it turns greyish and light. Porcelain (子 器) occurs on the surface of the lichen, black, the surface is dried, 1 ~ 2mm in diameter, spores are colorless, 1 thread. Seok is light in taste and is used a lot in tempura cooking. It contains a component of girofolic acid, which is used in Chinese medicine as a hemostatic agent for tonic, keratin, and bleeding. It is distributed in Korea (north of Gangwon), China, and Japan.

Camellia is an evergreen broad-leaved arboreous tree with tea tree, about 7m high, and leaves are alternately long oval. In April, large red or white flowers bloom beautifully at the end of branches. Fruits ripen late in autumn with a capsule. Fruits are medicinal or squeezed with oil and used as head oil and lamp oil. Wood is used as a craft material. It grows on warm coasts and is distributed in Korea, Japan, and China.

The cosmetic composition for anti-atopic dermatitis of the present invention comprises at least one cold water selected from the group consisting of gourd green leaf, green tea seed, Astragalus, dandelion, agaricus, dodol, stone and camellia with 0.01 to 10% by weight, based on the total weight of the cosmetic composition. It contains.

Hereinafter, the present invention will be described in more detail with reference to test examples, but the scope of the present invention is not limited only to these examples.

Reference Example Preparation of Extract of Natural Product

Each natural product is extracted by heating 1500g of ethanol (or water) in 300g, refluxed for 4 ~ 6 hours with or without heating, concentrated with an evaporator, and freeze-dried one by one or two according to the purpose. A cream formulation was made and used.

Test Example 1 Determination of Anti-Atopy Effect of Natural Products

One of the symptoms of atopic dermatitis was itching, and it was measured whether the natural product had an effect on atopy by inducing itching and scraping.

Compound 48/80, an itch-inducing substance, is applied to the back area of the chest behind the neck of the Sprague-Dawley neck, and 0.5% of compound 48/80 is applied to the skin. Scraping was performed. After 24 hours, a mixture of Compound 48/80 and the sample was applied 1: 1 and compared to the number of scratches for 1 hour. The natural products used in the experiments were Astragalus, Green Tea Seed, Agaricus, Dol-E, Park Jujube Leaf, and Maroon Seed, green tea, dandelion, stone and camellia extract. The number of scratches after applying Compound 48/80 was 100, and the number of scratches after mixing and mixing the sample with Compound 48/80 was shown in FIG. 1.

As can be seen from Figure 1 natural products of green leaf, green tea seeds, Astragalus, dandelion, agaricus, stone, seokki, camellia, etc. can be judged to be effective in relieving atopic symptoms because it has a good effect of suppressing itching. .

Test Example 2 Measurement of Moisturizing Effect of Natural Product

1 ml of agar made with 1.5% agar on a plate, put the same amount, weighed, coated 3 times or more with gelatin, and then 1 ml of a specific cosmetic product containing natural products The natural products used in the experiment were Dandelion (DAD), Cha (CJJ), Green Tea (GT), Astragalus (HWG), Seok (SUK), Green Tea Seed (GSE), Agaricus (AGA), and Roe Deer. Fungus mushrooms (NRM), Changchunhua (JCW), Cordyceps sinensis (DCHC) and Dol extraneous (CHIL) extracts. After 18 hours at 37 ℃ after the smear was weighed and the moisturizing effect was measured by the reduced ratio, the results are shown in FIG.

As can be seen through Figure 2, Dandelion (DAD), Astragalus (HWG), Suk (SUK), Green Tea Seed (GSE), Agaricus (AGA), Dol et al. CHIL) is also effective in maintaining moisturizing, which may help relieve atopic symptoms.

1 is a graph showing the number of scratches for 1 hour after applying the natural product and the material that induces itching in rats to determine whether the natural product is effective for atopy.

2 is a graph showing the moisturizing effect of natural products.

Claims (2)

It has an anti-atopic dermatitis effect by containing an extract of a natural product, which comprises at least one extract selected from the group consisting of gourd leaf, green tea seed, astragalus, dandelion, agaricus, dol, seokki and camellia skin as an active ingredient. Cosmetic composition. The cosmetic composition according to claim 1, wherein the active ingredient contains an extract of a natural product, which is contained in an amount of 0.01 to 10% by weight based on the total weight of the cosmetic composition.

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