CN105169199A - Traditional Chinese medicinal composition for treating functional dyspepsia with syndrome of liver-stomach disharmony - Google Patents
Traditional Chinese medicinal composition for treating functional dyspepsia with syndrome of liver-stomach disharmony Download PDFInfo
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Abstract
The invention belongs to the technical field of a medicine, and in particular relates to a traditional Chinese medicinal composition for treating functional dyspepsia with syndrome of liver-stomach disharmony. The traditional Chinese medicinal composition consists of the following components: radix bupleuri, fingered citron, dried orange peel, poria cocos, wrinkled gianthyssop herb, fructus amomi, rhizoma acori graminei, fructus evodiae, persimmon calyx, cuttlebone, pericarpium citri reticulatae viride and fructus aurantii. The traditional Chinese medicinal composition disclosed by the invention is reasonable in prescription and easy to prepare; the traditional Chinese medicinal composition is significant in curative effect on soothing liver and harmonizing stomach, regulating qi and removing dampness, lowering adverse flow of qi and making acid, removing stagnation and eliminating retention; and the traditional Chinese medicinal composition is an effective medicine for treating functional dyspepsia with syndrome of liver-stomach disharmony.
Description
Technical field
The invention belongs to medical art, relate to a kind of Chinese medicine composition for the treatment of liver-stomach disharmony type functional dyspepsia.
Background technology
Functional dyspepsia is otherwise known as non-ucler dyspepsia, gastrointestinal dysfunction, gastrointestinal neurosis, Gastrointestinal neurosis, is the general name of one group of gastrointestinal syndrome.There is epigastric discomfort, pain clinically, early full, abdominal distention, heating installation, poor appetite, acid regurgitation, heartburn, feel sick, the symptoms such as vomiting, and continue or recurrent exerbation.Medical inspection should be got rid of and find that there is the generation internal organs organic disease patients such as peptic ulcer, tumor, esophagitis regulating liver-QI, gallbladder, pancreas through detection meanss such as upper digestive tract barivm meal fluoroscopy (screem), endoscope, B ultrasonic.Primary disease belongs to common clinical, frequently-occurring disease, and functional dyspepsia symptom all appearred in most people, just course of disease length, and the order of severity is variant.Because rhythm of life is accelerated, life stress increases, the problem that each side such as environmental pollution are each, and the morbidity of liver-stomach disharmony type functional dyspepsia is in the trend risen year by year, although primary disease does not constitute threat to life, have a strong impact on quality of life and the life quality of patient.
Current doctor trained in Western medicine is completely not clear and definite to the etiology and pathogenesis of functional dyspepsia, there is no the effective etiology treatment of determined curative effect, just comprehensive anti symptom treatment, and side effect is more, most of patients can not adhere to taking medicine, and more, relapse rate is high for small number of patients Symptoms last difficulty.The traditional Chinese medical science without " functional dyspepsia " word, in allusion doctor nationality can with " swollen ", " distension ", " feeling of fullness " etc. are sick corresponding.The traditional Chinese medical science thinks that the basic sick position of primary disease is at stomach, with liver, spleen in close relations, middle burnt disorder of QI movement, taste lifting dereliction of duty, for causing this pathogenetic pathogenesis crucial, is mainly divided into syndrome of spleen-deficiency and QI-stagnation according to disease type, syndrome of incoordination between liver and stomach, syndrome of dampness-heat of spleen and stomach, syndrome of deficient cold of spleen and stomach, simultaneous occurrence of cold and heat syndromes etc.Chinese traditional treatment, by differential diagnosis of diseases and dialectical combination, can reach treating both the principal and secondary aspects of a disease and the little therapeutic effect of side effect, be worth research further also to be applied in clinical.
Summary of the invention
One is the object of the present invention is to provide to have prescription rigorous, compatibility science, evident in efficacy, curative effect of medication can be played to greatest extent, and easy to prepare, patient compliance is good, the Chinese medicine composition of the treatment liver-stomach disharmony type functional dyspepsia had no side effect.
For achieving the above object, technical scheme provided by the invention is the Chinese medicine composition of described treatment liver-stomach disharmony type functional dyspepsia, it is characterized in that described Chinese medicine composition is made up of the medicine of following weight: Radix Bupleuri 10-12 part, Fructus Citri Sarcodactylis 6-8 part, Pericarpium Citri Reticulatae 4-6 part, Poria 10-12 part, Herba Pogostemonis 5-7 part, Fructus Amomi 10-12 part, Rhizoma Acori Graminei 8-12 part, Fructus Evodiae 8-12 part, Calyx Kaki 8-10 part, Endoconcha Sepiae 4-6 part, Pericarpium Citri Reticulatae Viride 8-10 part, Fructus Aurantii 6-8 part.
Most preferred technique scheme of the present invention is that Chinese medicine composition of the present invention is obtained by the crude drug of following weight portion: Radix Bupleuri 11 parts, Fructus Citri Sarcodactylis 7 parts, Pericarpium Citri Reticulatae 5 parts, 11 parts, Poria, Herba Pogostemonis 6 parts, Fructus Amomi 11 parts, Rhizoma Acori Graminei 10 parts, Fructus Evodiae 10 parts, Calyx Kaki 9 parts, Endoconcha Sepiae 5 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 7 parts.
The dosage form of above-mentioned Chinese medicine composition is oral formulations.
Above-mentioned oral formulations is tablet, capsule or granule.
Above-mentioned oral formulations is that the preparation method step of tablet is as follows: take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Decoct twice, first time decocts 6 times amount that add water, and soaks 2h, decocts 3h, filters; Second time decocts 5 times amount that add water, and decocts 1.5h, collecting decoction, filters; When filtrate is concentrated into 55 DEG C, relative density is the clear paste of 1.10 ~ 1.15, and 50 DEG C of cold drying, are ground into fine powder, add appropriate amount of auxiliary materials, compress tablet coating.
Above-mentioned oral formulations is that the preparation method step of capsule is as follows: take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Decoct twice, first time decocts 6 times amount that add water, and soaks 2h, decocts 3h, filters; Second time decocts 5 times amount that add water, and decocts 1.5h, collecting decoction, filters; When filtrate is concentrated into 55 DEG C, relative density is the clear paste of 1.10 ~ 1.15, and 50 DEG C of cold drying, be ground into middle powder, add appropriate amount of auxiliary materials, mix homogeneously incapsulates.
Above-mentioned oral formulations is that the preparation method step of granule is as follows: take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Decoct twice, first time decocts 6 times amount that add water, and soaks 2h, decocts 3h, filters; Second time decocts 5 times amount that add water, and decocts 1.5h, collecting decoction, filters; When filtrate is concentrated into 55 DEG C, relative density is the clear paste of 1.10 ~ 1.15, adds appropriate dextrin and sucrose soft material, makes wet granular and cross 20 mesh sieves, and dry, granulate, sieves again, and pack is packed and be get final product.
The present invention relatively and prior art, has following clear superiority:
First, Chinese medicine composition prescription of the present invention is mainly transported as this according to the insufficiency of the spleen mistake of liver-stomach disharmony type functional dyspepsia, and stomach-QI being unable to descend normally is that target pathogenic characteristic develops, Radix Bupleuri in side, Fructus Citri Sarcodactylis, and dispersing the stagnated live-QI to relieve the stagnation of QI, regulates the flow of vital energy and show; Pericarpium Citri Reticulatae, Poria, spleen invigorating is regulated the flow of vital energy, promoting diuresis to eliminate damp pathogen; Herba Pogostemonis, Fructus Amomi, Rhizoma Acori Graminei, removing dampness to restore normal function of the stomach, refreshment Fructus Alpiniae Oxyphyllae; Fructus Evodiae, Calyx Kaki, Endoconcha Sepiae, pain relieving antacid, stopping nausea and vomiting by lowering the adverse flow of QI; Pericarpium Citri Reticulatae Viride, Fructus Aurantii, dispelling the stagnated QI relieving distension, row long-pendingization is stagnant.Full side plays dispersing the stagnated liver-QI for regulating the stomach altogether, regulating QI to expel dampness, sending down the abnormal ascending QI antacid, the merit that removing food stagnancyization is stagnant, has extremely strong specific aim curative effect to liver-stomach disharmony type functional dyspepsia.Through clinical practice checking, its determined curative effect, mild in medicine property and, do not occur toxic and side effects and untoward reaction, safety coefficient is high.Chinese medicine preparation of the present invention adopts advanced extraction equipment and technique, abundant effective component extracting, can be made into and facilitates Chinese medicine preparation that is oral or that carry.
Further, in Chinese medicine composition of the present invention, the function of each crude drug and function cure mainly:
Radix Bupleuri, bitter, be slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.Reducing fever by reconciliation should give birth to use, evacuates the suitable processed with vinegar Radix Bupleuri (processed with vinegar) of stagnation of liver-QI, sprays after namely drying cutting with Radix Bupleuri with rice vinegar, vexed, is used as medicine with the micro-stir-fry of slow fire.
Fructus Citri Sarcodactylis, pungent, bitter, sour, temperature.Return liver, spleen, lung meridian.Liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.
Pericarpium Citri Reticulatae, bitter, pungent, temperature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Poria is sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Herba Pogostemonis, acrid in the mouth; Slightly warm in nature returns lung; Spleen; Stomach is through dispelling summer-heat from superficies of the body; Removing dampness to restore normal function of the stomach.Main summertime flu; Cold and heat are had a headache; Breast gastral cavity painful abdominal mass is vexed; Vomiting is had loose bowels; Vomiting during pregnancy; Nasal sinusitis; Hands; Tinea pedis.
Fructus Amomi, acrid in the mouth; Warm in nature; Spleen; Stomach; Kidney channel; Removing dampness is whetted the appetite; It is antiabortive that promoting the circulation of QI to alleviate the stagnation in middle-JIAO is warming spleen and stopping diarrha.Main retention of damp leading to blockage of QI; Distension and fullness in the abdomen; Anorexia; Nausea and vomiting; Stomachache is had loose bowels pregnancy reactions; Frequent fetal movement.
Rhizoma Acori Graminei, pungent, bitter, temperature.GUIXIN, stomach warp.Removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.
Fructus Evodiae, arduous, temperature.Enter liver, stomach warp.Warming middle-JIAO, pain relieving, regulates the flow of vital energy, dampness, and stopping vomiting is against acid regurgitation, and headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, abdominal pain during menstruation, Diarrhoea, vascular hypertension, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.
Calyx Kaki is bitter, puckery, flat.Return stomach warp.Lowering the adverse flow of QI.For singultus.
Endoconcha Sepiae, salty, puckery, temperature.Return spleen, kidney channel.Astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, sore.For acid regurgitation of having a stomachache, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge; Peptic Ulcers.External treatment bleeding due to trauma, the many pus of skin ulcer.
Pericarpium Citri Reticulatae Viride, bitter, pungent, temperature.Return liver, gallbladder, stomach warp.Soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.For distending pain in the chest and hypochondrium, hernia, nodule in the breast, acute mastitis, abdominal pain due to retention of food.
Fructus Aurantii, bitter, pungent, sour, temperature.Return spleen, stomach warp.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.
The present invention also asks the purposes protecting above-mentioned Chinese medicine composition in the medicine of preparation treatment liver-stomach disharmony type functional dyspepsia.In clinical observation process, 165 routine patients all complete clinical observation, exit case without coming off.The routine clinical patients for the treatment of group 55, recovery from illness 20 example, effective 18 examples, effective 13 examples, invalid 4 examples, total effective rate reaches 92.7%; Routine clinical patients recovery from illness 10 example of contrast a group 55, effective 14 examples, effective 19 examples, invalid 12 examples, total effective rate reaches 78.2%; Routine clinical patients recovery from illness 7 example of contrast b group 55, effective 15 examples, effective 18 examples, invalid 15 examples, total effective rate reaches 72.7%.Three groups of therapeutic outcomes compare, and treatment group clinical effectiveness in cure rate and total effective rate is more remarkable, though have certain difference between contrast a, b two groups, difference is not obvious, does not have statistical significance.This clinical trial results shows that Chinese medicine composition synergism of the present invention is strong, can improve the physiological function of patient, have outstanding therapeutical effect to incoordination between the liver and stomach disease functional dyspepsia.So reduce medical material or change medical material simply simply in the present invention in drug composition, clinical therapeutic efficacy disappears, and does not have therapeutical effect.Meanwhile, in treatment group therapeutic process, vital sign is steadily and without serious adverse reactions such as allergy, treatment terminates rear lab index routine blood test, electrocardiogram etc. to the routine patient for the treatment of group 55 and carries out statistical procedures, shows no obvious abnormalities.Result shows that the clinical application of we is safely and effectively, is worth studying and applying further.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 tablet
The each raw material of the present invention is taken: Radix Bupleuri 11 parts, Fructus Citri Sarcodactylis 7 parts, Pericarpium Citri Reticulatae 5 parts, 11 parts, Poria, Herba Pogostemonis 6 parts, Fructus Amomi 11 parts, Rhizoma Acori Graminei 10 parts, Fructus Evodiae 10 parts, Calyx Kaki 9 parts, Endoconcha Sepiae 5 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 7 parts by following weight portion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Decoct twice, first time decocts 6 times amount that add water, and soaks 2h, decocts 3h, filters; Second time decocts 5 times amount that add water, and decocts 1.5h, collecting decoction, filters; When filtrate is concentrated into 55 DEG C, relative density is the clear paste of 1.10 ~ 1.15, and 50 DEG C of cold drying, be ground into fine powder, add appropriate amount of auxiliary materials, namely compress tablet coating obtains Tablets.
When using traditional Chinese medicine composition for treating liver-stomach disharmony type functional dyspepsia of the present invention, take prepared tablet, every contains crude drug amount 0.2g, and every day 3 times, each 2-3 sheet, takes after meal half an hour.
Embodiment 2 capsule
The each raw material of the present invention is taken: Radix Bupleuri 11 parts, Fructus Citri Sarcodactylis 7 parts, Pericarpium Citri Reticulatae 5 parts, 11 parts, Poria, Herba Pogostemonis 6 parts, Fructus Amomi 11 parts, Rhizoma Acori Graminei 10 parts, Fructus Evodiae 10 parts, Calyx Kaki 9 parts, Endoconcha Sepiae 5 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 7 parts by following weight portion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Decoct twice, first time decocts 6 times amount that add water, and soaks 2h, decocts 3h, filters; Second time decocts 5 times amount that add water, and decocts 1.5h, collecting decoction, filters; When filtrate is concentrated into 55 DEG C, relative density is the clear paste of 1.10 ~ 1.15, and 50 DEG C of cold drying, are ground into middle powder, add appropriate amount of auxiliary materials, and mix homogeneously incapsulates and obtain capsule of the present invention.
When using traditional Chinese medicine composition for treating liver-stomach disharmony type functional dyspepsia of the present invention, take prepared capsule, every contains crude drug amount 0.2g, and every day 3 times, each 2-3 grain, takes after meal half an hour.
Embodiment 3 granule
The each raw material of the present invention is taken: Radix Bupleuri 11 parts, Fructus Citri Sarcodactylis 7 parts, Pericarpium Citri Reticulatae 5 parts, 11 parts, Poria, Herba Pogostemonis 6 parts, Fructus Amomi 11 parts, Rhizoma Acori Graminei 10 parts, Fructus Evodiae 10 parts, Calyx Kaki 9 parts, Endoconcha Sepiae 5 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 7 parts by following weight portion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Decoct twice, first time decocts 6 times amount that add water, and soaks 2h, decocts 3h, filters; Second time decocts 5 times amount that add water, and decocts 1.5h, collecting decoction, filters; When filtrate is concentrated into 55 DEG C, relative density is the clear paste of 1.10 ~ 1.15, adds appropriate dextrin and sucrose soft material, makes wet granular and cross 16 mesh sieves, and dry, granulate, sieves again, and granule of the present invention is packed and obtained in pack.
When using traditional Chinese medicine composition for treating liver-stomach disharmony type functional dyspepsia of the present invention, take prepared granule, containing crude drug amount 0.5g, every day 3 times, each 1 bag, take half an hour after meal for every bag.
Embodiment 4 tablet
The each raw material of the present invention is taken: Radix Bupleuri 10 parts, Fructus Citri Sarcodactylis 6 parts, Pericarpium Citri Reticulatae 4 parts, 10 parts, Poria, Herba Pogostemonis 5 parts, Fructus Amomi 10 parts, Rhizoma Acori Graminei 8 parts, Fructus Evodiae 8 parts, Calyx Kaki 8 parts, Endoconcha Sepiae 4 parts, 8 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 6 parts by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 5 tablet
The each raw material of the present invention is taken: Radix Bupleuri 12 parts, Fructus Citri Sarcodactylis 8 parts, Pericarpium Citri Reticulatae 6 parts, 12 parts, Poria, Herba Pogostemonis 7 parts, Fructus Amomi 12 parts, Rhizoma Acori Graminei 12 parts, Fructus Evodiae 12 parts, Calyx Kaki 10 parts, Endoconcha Sepiae 6 parts, 10 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 8 parts by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 6 tablet
The each raw material of the present invention is taken: Radix Bupleuri 20 parts, Fructus Citri Sarcodactylis 5 parts, Pericarpium Citri Reticulatae 12 parts, 8 parts, Poria, Herba Pogostemonis 10 parts, Fructus Amomi 8 parts, Rhizoma Acori Graminei 15 parts, Fructus Evodiae 15 parts, Calyx Kaki 5 parts, Endoconcha Sepiae 6 parts, 10 parts, Pericarpium Citri Reticulatae Viride by following weight portion.
Preparation technology is with embodiment 1.
The clinical observation of embodiment 7 traditional Chinese medicine composition for treating liver-stomach disharmony type of the present invention functional dyspepsia
1, case-data: select hospital's Digestive System Department outpatient service and ward, doctor trained in Western medicine meets Rome III functional dyspepsia diagnostic criteria, tcm diagnosis standard with reference to " dyspepsia Chinese traditional medical diagnose National Consensus " feeling of fullness, stomachache, stomachache diagnostic criteria, and dialectical is liver-stomach disharmony type patient 165 example.Wherein man 41 example, female 69 example, 20 ~ 55 years old age, 45.2 years old mean age, the course of disease 1 ~ 5 year, average course of disease 2.76 years.Be divided into treatment group and contrast a group, contrast b group at random, each 55 examples, compare three groups of basic datas, the sex, age, the course of disease etc. of three groups of patients, without significant difference, have comparability.
Incoordination between the liver and stomach disease functional dyspepsia disease is seen:
Primary symptom: 1. distension and fullness in the abdomen; 2. gastralgia; 3. sighing frequently.
Secondary disease: 1. belch acid regurgitation; 2. decreased food intake of receiving is few; 3. nausea and vomiting; 4. coerce rib and alter pain; 5. defecate not well; 6. light red tongue, white and thin fur; 7. stringy and thready pulse.
Syndrome is determined: all possess primary symptom 3 or primary symptom 2 and add time disease 2, can dialectical be liver-stomach disharmony type FD.
2, case exclusion standard:
(1) digestive system organic disease (as gastric mucosal erosion, Peptic Ulcers, gastrointestinal tumor, the hepatobiliary and pancreatic diseases) person of other influences gastric motility is had;
(2) general or other system disease (as connective tissue disease, endocrinopathyes such as diabetes) person is had;
(3) with other serious disease persons, as the serious organ functional lesion person such as the constitutional heart, liver, kidney or there is Abdomen Trauma history person;
(4) gestation or women breast-feeding their children;
(5) experimenter be unwilling to participate in clinical trial person or mental disorder can not compatibility test person;
(6) accepting at present to use similar drugs person in other medicines clinical trial person or nearly two weeks;
(7) allergic constitution or multi-medicament allergy sufferers;
(8) because intelligence or behavior disorder can not give abundant informed consent person;
(9) suspect or truly have ethanol, history of substance abuse person.
3, Therapeutic Method:
Treatment group: tablet prepared by the oral embodiment of the present invention 1, containing crude drug amount 0.2g, every day 3 times, each 3, takes for every after meal half an hour.
Contrast a group: tablet prepared by the oral embodiment of the present invention 6, containing crude drug amount 0.2g, every day 3 times, each 3, takes for every after meal half an hour.
Contrast b group: give domperidone tablet (motilium, Xian-Janssen Pharmaceutical Ltd. produces), every sheet 10mg, each a slice, every day three times 1, takes before the meal half an hour.
Three groups were for 4 courses for the treatment of Monday, and treatments period is all stopped using the Chinese and western drugs of other all treatment functional dyspepsias, irritable food, diet sweets, the strong tea etc. such as simultaneously advise patient to avoid pungent food, greasy.
4, criterion of therapeutical effect carries out disease clinical development by " new Chinese medicine guideline of clinical investigations " curative effect determinate standard:
(1) fully recover: symptom, sign disappears or substantially disappears, and syndrome integral reduces >=95%.
(2) effective: symptom, sign is obviously improved, and syndrome integral reduces >=70%.
(3) effective: symptom, sign all take a favorable turn, and syndrome integral reduces >=30%.
(4) invalid: symptom, sign is all not improved, even increase the weight of, syndrome integral reduces less than 30%.
Note: computing formula (nimodipine method) is: integration × 100% before (before treatment the rear integration of integration-treatment)/treatment.
Total effective rate=(recovery from illness example+effective example+effectively example)/total number of cases × 100%.
5, therapeutic effect:
In clinical observation process, 165 routine patients all complete clinical observation, exit case without coming off.The routine clinical patients for the treatment of group 55, recovery from illness 20 example, effective 18 examples, effective 13 examples, invalid 4 examples, total effective rate reaches 92.7%; Routine clinical patients recovery from illness 10 example of contrast a group 55, effective 14 examples, effective 19 examples, invalid 12 examples, total effective rate reaches 78.2%; Routine clinical patients recovery from illness 7 example of contrast b group 55, effective 15 examples, effective 18 examples, invalid 15 examples, total effective rate reaches 72.7%.Concrete data see the following form.Three groups of therapeutic outcomes compare, and treatment group clinical effectiveness in cure rate and total effective rate is more remarkable, though have certain difference between contrast a, b two groups, difference is not obvious, does not have statistical significance.
Three groups of therapeutic outcomes compare, and treatment group clinical effectiveness in cure rate and total effective rate is more remarkable.In addition, in treatment group therapeutic process, vital sign is steadily and without serious adverse reactions such as allergy, treatment terminates rear lab index routine blood test, routine urinalysis, electrocardiogram etc. to treatment group patient and carries out statistical procedures, shows no obvious abnormalities.Result shows that the clinical application of we is safely and effectively, is worth studying and applying further.
Claims (8)
1. treat a Chinese medicine composition for liver-stomach disharmony type functional dyspepsia, it is characterized in that, it is obtained by the crude drug of following weight portion: Radix Bupleuri 10-12 part, Fructus Citri Sarcodactylis 6-8 part, Pericarpium Citri Reticulatae 4-6 part, Poria 10-12 part, Herba Pogostemonis 5-7 part, Fructus Amomi 10-12 part, Rhizoma Acori Graminei 8-12 part, Fructus Evodiae 8-12 part, Calyx Kaki 8-10 part, Endoconcha Sepiae 4-6 part, Pericarpium Citri Reticulatae Viride 8-10 part, Fructus Aurantii 6-8 part.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, it is obtained by the crude drug of following weight portion: Radix Bupleuri 11 parts, Fructus Citri Sarcodactylis 7 parts, Pericarpium Citri Reticulatae 5 parts, 11 parts, Poria, Herba Pogostemonis 6 parts, Fructus Amomi 11 parts, Rhizoma Acori Graminei 10 parts, Fructus Evodiae 10 parts, Calyx Kaki 9 parts, Endoconcha Sepiae 5 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 7 parts.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that, described Chinese medicine composition is oral formulations.
4. Chinese medicine composition as claimed in claim 3, it is characterized in that, described oral formulations is preferably tablet, capsule or granule.
5. Chinese medicine composition as claimed in claim 4, it is characterized in that, the preparation method of described tablet has the following steps: take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Decoct twice, first time decocts 6 times amount that add water, and soaks 2h, decocts 3h, filters; Second time decocts 5 times amount that add water, and decocts 1.5h, collecting decoction, filters; When filtrate is concentrated into 55 DEG C, relative density is the clear paste of 1.10 ~ 1.15, and 50 DEG C of cold drying, are ground into fine powder, add appropriate amount of auxiliary materials, compress tablet coating.
6. Chinese medicine composition as claimed in claim 4, it is characterized in that, the preparation method of described capsule has the following steps: take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Decoct twice, first time decocts 6 times amount that add water, and soaks 2h, decocts 3h, filters; Second time decocts 5 times amount that add water, and decocts 1.5h, collecting decoction, filters; When filtrate is concentrated into 55 DEG C, relative density is the clear paste of 1.10 ~ 1.15, and 50 DEG C of cold drying, be ground into middle powder, add appropriate amount of auxiliary materials, mix homogeneously incapsulates.
7. Chinese medicine composition as claimed in claim 4, it is characterized in that, the preparation method of described granule has the following steps: take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Decoct twice, first time decocts 6 times amount that add water, and soaks 2h, decocts 3h, filters; Second time decocts 5 times amount that add water, and decocts 1.5h, collecting decoction, filters; When filtrate is concentrated into 55 DEG C, relative density is the clear paste of 1.10 ~ 1.15, adds appropriate dextrin and sucrose soft material, makes wet granular and cross 20 mesh sieves, and dry, granulate, sieves again, and pack is packed and be get final product.
8. the purposes of Chinese medicine composition as claimed in claim 1 or 2 in the medicine of preparation treatment liver-stomach disharmony type functional dyspepsia.
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| CN110301627A (en) * | 2018-03-27 | 2019-10-08 | 上海市浦东新区公利医院 | A kind of soothing liver and strengthening spleen resolving sputum edible composition and its application |
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| WO2011126295A2 (en) * | 2010-04-06 | 2011-10-13 | (주)아모레퍼시픽 | Wrapping fermentation method using medicinal leaves, and composition for external skin application using same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110301627A (en) * | 2018-03-27 | 2019-10-08 | 上海市浦东新区公利医院 | A kind of soothing liver and strengthening spleen resolving sputum edible composition and its application |
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