CN104758712A - Traditional Chinese medicine composition for treating reflux esophagitis - Google Patents
Traditional Chinese medicine composition for treating reflux esophagitis Download PDFInfo
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- CN104758712A CN104758712A CN201510216552.0A CN201510216552A CN104758712A CN 104758712 A CN104758712 A CN 104758712A CN 201510216552 A CN201510216552 A CN 201510216552A CN 104758712 A CN104758712 A CN 104758712A
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Abstract
The invention belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine composition for treating the reflux esophagitis. The traditional Chinese medicine composition comprises, by weight, 16 parts to 20 parts of fingered citron, 10 parts to 14 parts of caulis bambusae in taeniam, 10 parts to 12 parts of cuttlebones, 8 parts to 10 parts of combined spicebush roots, 8 parts to 10 parts of codonopsis pilosula, 6 parts to 9 parts of pericarpium citri reticulatae, 10 parts to 12 parts of fructus evodiae, 10 parts to 12 parts of fructus aurantii, 8 parts to 12 parts of dandelions and 6 parts to 8 parts of agilawood. The traditional Chinese medicine composition is reasonable in component and easy to prepare, has the remarkable curative effects of soothing the liver, regulating qi, harmonizing the stomach, calming the adverse-rising energy, clearing away heat, reducing phlegm, relieving hyperacidity and stopping pains, and is effective medicine for treating the reflux esophagitis, in particular to the qi depression phlegm blocking type reflux esophagitis.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine composition for the treatment of reflux esophagitis.
Background technology
Reflux esophagitis (reflux esophagitis, RE) means because stomach and (or) duodenum content reflux enter esophagus, causes the pathological changes such as the inflammation of mucous membrane of esophagus, erosion, ulcer and fibrosis, belongs to gastroesophageal reflux disease.The prerequisite of reflux esophagitis is caused to be that gastric content crosses lower esophageal sphincter (LES) reflux in esophagus, and reflux thing can not be removed by esophagus itself as soon as possible, cause gastric content in Endo-esophageal long-time delay, the impairment factor in gastric content such as acid, bile acid, pepsin etc. cause reflux esophagitis to the damage of Esophageal Mucosa.Reflux esophagitis reflux esophagitis is due to the quickening of rhythm of life, and the increasing of life stress, the problem that each side such as environmental pollution are each, the morbidity of reflux esophagitis is in the trend risen year by year.
The traditional Chinese medical science is divided into according to the clinical symptoms of reflux esophagitis more: syndrome of liver-stomach heat is demonstrate,proved, and stagnation of QI causing phlegm retention is demonstrate,proved, syndrome of incoordination between liver and stomach, middle empty syndrome of adverseness of QI, the pattern of syndrome such as liver-heat syndrome of spleen-deficiency.Wherein stagnation of QI causing phlegm retention card is Common Syndromes, multiple card.The main disease of stagnation of QI causing phlegm retention type is seen: septum pectorale feeling of fullness, general saliva of spitting, acid regurgitation heating installation, and the state of an illness can increase and decrease with emotion changes, light red tongue or in vain light, greasy and thin fur, stringy and rolling pulse.The traditional Chinese medical science think assertive evidence many because of feelings will unsuccessful, depressed rage impairing the liver, liver lose bar reach, horizontal take advantage of spleen soil; Or eating and drinking without temperance, overstrain internal injury, impairing the spleen and stomach, taste lifting imbalance, soil is counter insults wood, and the liver failing to maintain the normal flow of QI forms.Western medicine primary disease not only side effect is large, relapse rate is high, and long-term treatment financial burden weight, increasing clinical report display, Chinese medicine has significant curative effect in treatment RE, therefore develops effective Chinese medicine preparation treatment primary disease in conjunction with modern Chinese medicine technology necessary.
Summary of the invention
One is the object of the present invention is to provide to have prescription rigorous, compatibility science, evident in efficacy, curative effect of medication can be played to greatest extent, and easy to prepare, patient compliance is good, the Chinese medicine composition of the treatment reflux esophagitis had no side effect.
For achieving the above object, technical scheme provided by the invention is the Chinese medicine composition of described treatment reflux esophagitis, it is characterized in that described Chinese medicine composition is made up of the medicine of following weight: Fructus Citri Sarcodactylis 16-20 part, Caulis Bambusae In Taenia 10-14 part, Endoconcha Sepiae 10-12 part, Radix Linderae 8-10 part, Radix Codonopsis 8-10 part, Pericarpium Citri Reticulatae 6-9 part, Fructus Evodiae 10-12 part, Fructus Aurantii 10-12 part, Herba Taraxaci 8-12 part, Lignum Aquilariae Resinatum 6-8 part.
Most preferred technique scheme of the present invention is that Chinese medicine composition of the present invention is obtained by the raw material of following weight portion: Fructus Citri Sarcodactylis 18 parts, Caulis Bambusae In Taenia 12 parts, Endoconcha Sepiae 11 parts, the Radix Linderae 9 parts, Radix Codonopsis 9 parts, Pericarpium Citri Reticulatae 7 parts, Fructus Evodiae 11 parts, Fructus Aurantii 11 parts, Herba Taraxaci 10 parts, Lignum Aquilariae Resinatum 7 parts.
The dosage form of above-mentioned Chinese medicine composition is oral formulations.
Above-mentioned oral formulations is tablet, capsule or granule.
Above-mentioned oral formulations is that the preparation method step of tablet is as follows: take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Each decoction adds water 5 times amount, decocts secondary, each 2 hours, collecting decoction, filters; Filtrate is concentrated into the clear paste that relative density is 1.14 ~ 1.18, and 50 DEG C of cold drying, are ground into fine powder, add appropriate amount of auxiliary materials, compress tablet coating.
Above-mentioned oral formulations is that the preparation method step of capsule is as follows: take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Each decoction adds water 5 times amount, decocts secondary, each 2 hours, collecting decoction, filters; Filtrate is concentrated into the clear paste that relative density is 1.14 ~ 1.18, and 50 DEG C of cold drying, be ground into middle powder, add appropriate amount of auxiliary materials, mix homogeneously incapsulates.
Above-mentioned oral formulations is that the preparation method step of granule is as follows: take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Each decoction adds water 5 times amount, decocts secondary, each 2 hours, collecting decoction, filters; Filtrate is concentrated into the clear paste that relative density is 1.14 ~ 1.18, adds appropriate dextrin and sucrose soft material, makes wet granular and crosses 16 mesh sieves, and dry, granulate, sieves again, and pack is packed and be get final product.
The present invention relatively and prior art, has following clear superiority:
First, Chinese medicine composition prescription of the present invention mainly develops according to the pathogenic characteristic of patients with reflux esophagitis, Fructus Citri Sarcodactylis, the Radix Linderae, Lignum Aquilariae Resinatum liver-smoothing, qi-regulating in side, and stomach and alleviating pain; Endoconcha Sepiae, Fructus Evodiae antacid sore, regulating QI to relieve pain; Herba Taraxaci, Caulis Bambusae In Taenia, Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, removing heat-phlegm; Radix Codonopsis, Fructus Aurantii invigorating the spleen and replenishing QI, the stagnant relieving distension of row.Full side plays activating QI to eliminate phlegm altogether, sending down the abnormal ascending QI antacid, and the merit of stomach and alleviating pain, has extremely strong specific aim curative effect to reflux esophagitis.Through clinical practice checking, its determined curative effect, mild in medicine property and, do not occur toxic and side effects and untoward reaction, safety coefficient is high.Chinese medicine preparation of the present invention adopts advanced extraction equipment and technique, abundant effective component extracting, can be made into and facilitates Chinese medicine preparation that is oral or that carry.
Further, in Chinese medicine composition of the present invention, the function of each crude drug and function cure mainly:
Fructus Citri Sarcodactylis, pungent, bitter, sour, temperature.Return liver, spleen, lung meridian.Liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.
Caulis Bambusae In Taenia, sweet, be slightly cold.Attach to the lung and stomach meridians.Removing heat-phlegm, relieves restlessness and prevents vomiting.For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, and eye is lost in palpitation with fear, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.
Endoconcha Sepiae, salty, puckery, temperature.Return spleen, kidney channel.Astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, sore.For acid regurgitation of having a stomachache, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge; Peptic Ulcers.External treatment bleeding due to trauma, the many pus of skin ulcer.
The Radix Linderae, pungent, temperature.Enter spleen, lung, kidney, urinary bladder channel.Pleasant, dissipating depression of QI, cold expelling, pain relieving.Control QI rising in reverse order chest and abdomen swelling and pain, dyspepsia does not disappear, and food is told in regurgitation, colic of cold type, beriberi, frequent micturition.
Radix Codonopsis, sweet, flat.Start with, meridian of Foot-TAI YIN edema caused by disorder of QI.Invigorating middle warmer, QI invigorating, promotes the production of body fluid.Control weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.
Pericarpium Citri Reticulatae, bitter, pungent, temperature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Fructus Evodiae, arduous, temperature.Enter liver, stomach warp.Warming middle-JIAO, pain relieving, regulates the flow of vital energy, dampness, and stopping vomiting is against acid regurgitation, and headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, abdominal pain during menstruation, Diarrhoea, vascular hypertension, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.
Fructus Aurantii, bitter, pungent, sour, temperature.Return spleen, stomach warp.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.
Herba Taraxaci, bitter, sweet, cold.Return liver, stomach warp.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Lignum Aquilariae Resinatum, pungent, bitter, tepor.Return spleen, stomach, kidney channel.Promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.For the vexed pain of breast abdominal distention, gastrofrigid vomiting singultus, QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.
The present invention also asks the purposes protecting above-mentioned Chinese medicine composition in the medicine of preparation treatment reflux esophagitis.In clinical observation process, 80 routine patients with reflux esophagitis are divided into two groups to treat at random, and after two courses for the treatment of terminate, between two groups, total effective rate compares, treatment group curative effect total effective rate 90%, matched group total effective rate 70%.Treatment group is apparently higher than matched group, and difference has statistical significance (P < 0.05).In treatment group therapeutic process, vital sign steadily and without serious adverse reactions such as allergy, treatment terminates rear lab index routine blood test, electrocardiogram etc. to the routine patient for the treatment of group 40 and carries out statistical procedures, shows no obvious abnormalities.Result shows that the clinical application of we is safely and effectively, is worth studying and applying further.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
The each raw material of the present invention is taken: Fructus Citri Sarcodactylis 18 parts, Caulis Bambusae In Taenia 12 parts, Endoconcha Sepiae 11 parts, the Radix Linderae 9 parts, Radix Codonopsis 9 parts, Pericarpium Citri Reticulatae 7 parts, Fructus Evodiae 11 parts, Fructus Aurantii 11 parts, Herba Taraxaci 10 parts, Lignum Aquilariae Resinatum 7 parts by following weight portion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Each decoction adds water 5 times amount, decocts secondary, each 2 hours, collecting decoction, filters; Filtrate is concentrated into the clear paste that relative density is 1.14 ~ 1.18, and 50 DEG C of cold drying, be ground into fine powder, add appropriate amount of auxiliary materials, namely compress tablet coating obtains Tablets.
When using traditional Chinese medicine composition for treating reflux esophagitis of the present invention, take prepared tablet, every sheet is containing crude drug amount 0.2g, and every day 3 times, each 2-3 sheet, takes after meal half an hour.
Embodiment 2
The each raw material of the present invention is taken: Fructus Citri Sarcodactylis 18 parts, Caulis Bambusae In Taenia 12 parts, Endoconcha Sepiae 11 parts, the Radix Linderae 9 parts, Radix Codonopsis 9 parts, Pericarpium Citri Reticulatae 7 parts, Fructus Evodiae 11 parts, Fructus Aurantii 11 parts, Herba Taraxaci 10 parts, Lignum Aquilariae Resinatum 7 parts by following weight portion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Each decoction adds water 5 times amount, decocts secondary, each 2 hours, collecting decoction, filters; Filtrate is concentrated into the clear paste that relative density is 1.14 ~ 1.18, and 50 DEG C of cold drying, are ground into middle powder, add appropriate amount of auxiliary materials, and mix homogeneously incapsulates and obtain capsule of the present invention.
When using traditional Chinese medicine composition for treating reflux esophagitis of the present invention, take prepared capsule, every contains crude drug amount 0.1g, and every day 3 times, each 4-6 grain, takes after meal half an hour.
Embodiment 3
The each raw material of the present invention is taken: Fructus Citri Sarcodactylis 18 parts, Caulis Bambusae In Taenia 12 parts, Endoconcha Sepiae 11 parts, the Radix Linderae 9 parts, Radix Codonopsis 9 parts, Pericarpium Citri Reticulatae 7 parts, Fructus Evodiae 11 parts, Fructus Aurantii 11 parts, Herba Taraxaci 10 parts, Lignum Aquilariae Resinatum 7 parts by following weight portion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Each decoction adds water 5 times amount, decocts secondary, each 2 hours, collecting decoction, filters; Filtrate is concentrated into the clear paste that relative density is 1.14 ~ 1.18, adds appropriate dextrin and sucrose soft material, makes wet granular and crosses 16 mesh sieves, and dry, granulate, sieves again, and granule of the present invention is packed and obtained in pack.
When using traditional Chinese medicine composition for treating reflux esophagitis of the present invention, take prepared granule, containing crude drug amount 0.5g, every day 3 times, each 1 bag, take half an hour after meal for every bag.
Embodiment 4
The each raw material of the present invention is taken: Fructus Citri Sarcodactylis 16 parts, Caulis Bambusae In Taenia 10 parts, Endoconcha Sepiae 10 parts, the Radix Linderae 8 parts, Radix Codonopsis 8 parts, Pericarpium Citri Reticulatae 6 parts, Fructus Evodiae 10 parts, Fructus Aurantii 10 parts, Herba Taraxaci 8 parts, Lignum Aquilariae Resinatum 6 parts by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 5
The each raw material of the present invention is taken: Fructus Citri Sarcodactylis 20 parts, Caulis Bambusae In Taenia 14 parts, Endoconcha Sepiae 12 parts, the Radix Linderae 10 parts, Radix Codonopsis 10 parts, Pericarpium Citri Reticulatae 9 parts, Fructus Evodiae 12 parts, Fructus Aurantii 12 parts, Herba Taraxaci 12 parts, Lignum Aquilariae Resinatum 8 parts by following weight portion.
Preparation technology is with embodiment 1.
The clinical observation of embodiment 6 traditional Chinese medicine composition for treating reflux esophagitis of the present invention
1, case-data: select hospital's taste, the outpatient service of hepatopathy section and ward, meets patient 80 example that RE diagnoses, Chinese medical discrimination is stagnation of QI causing phlegm retention type.Parallel control method is adopted to be divided into treatment group and matched group, each 40 examples.Wherein treatment group man 18 example, female 22 example; Matched group man 19 example, female 21 example; Treatment group age 26-64 year, matched group 24-64 year.Two groups of basic datas are compared, two groups at sex, age, the course of disease, scope by stages, before and after treatment in each symptom integral etc. through statistical procedures there are no significant difference (P>0.05), there is comparability.
1, Therapeutic Method:
Treatment group: tablet prepared by the oral embodiment of the present invention 1, every sheet is containing crude drug amount 0.2g, and every day 3 times, each 2-3 sheet, takes after meal half an hour.
Matched group: oral Omeprazole Enteric-coated Tablets (10mg/ sheet, AstraZeneca pharmaceutical Co. Ltd provides, lot number: J20080097) and domperidone tablet (10mg/ sheet, Arstwyth (Foshan) pharmaceutical Co. Ltd provides, lot number: H20093370).
Two groups were for 4 courses for the treatment of Monday, and treatments period is all stopped using the Chinese and western drugs of other all treatment RE, irritable food, diet sweets, the strong tea etc. such as simultaneously advise patient to avoid pungent food, greasy.Withdrawal after 2 courses for the treatment of, and carry out therapeutic evaluation.
3, efficacy determination
Clinical efficacy evaluation criteria: with reference to " new Chinese medicine guideline of clinical investigations "
Clinical recovery: clinical symptoms, sign disappear, gastroscopy recovers normal, are judged as 0 grade;
Effective: clinical cardinal symptom, sign disappear substantially, integration reduces more than 2/3, and gastroscope classification reduces 1-2 level;
Effective: cardinal symptom, sign alleviate, integration reduces more than 1/3, and gastroscopy classification reduces little;
Invalid: not reach above-mentioned effective standard or deterioration person, endoscopic grading is unchanged or increase.
Symptom scores carries out classification according to severity of symptom and scores, points 6 grades (have no precedent, very slight, slight, moderate, in severe, severe) remember 0,1,2,3,4,5 point respectively, standard is: 0 point, asymptomatic; L divides, and symptom is not obvious, finds under doctor reminds; 2 points, symptom is between 1 point and 3 points; 3 points, symptom is obvious, affects daily life, takes medicine once in a while; 4 points, symptom is between 3 points and 5 points; 5 points, symptom clearly, affects daily life, needs Long-term taking medicine to treat.
The discussion that Gastroscope Diagnosis standard and classification are carried out on February 7th, 2004 according to digestive endoscopy branch of Chinese Medical Association, " the reflux esophagitis Treatment and diagnosis guide " of unification, 0 grade: Esophageal Mucosa normal (change can be learned in a organized way); I grade: Esophageal Mucosa have point-like or strip rubescent, rotten to the corn, amixis phenomenon; II grade: have strip rubescent, rotten to the corn, and have fusion, but be not all-round property, merge < 75%; III grade: pathological changes is extensive, rubescent, rotten to the corn fusion is all-round property, merges >=75%.And differentiate that the Esophageal Mucosa that eliminating Candosis Esophagitis and chemical factors cause changes.
4, therapeutic effect:
In clinical observation process, 80 routine patients all complete clinical observation.After 2 courses for the treatment of terminate, the routine reflux esophagitis clinical patients for the treatment of group 40, recovery from illness 8 example, effective 18 examples, effective 11 examples, invalid 3 examples, total effective rate reaches 92.5%.Matched group recovery from illness 6 example, effective 12 examples, effective 13 examples, no effect 9, total effective rate reaches 77.5%.Two groups of therapeutic outcomes compare, and treatment group clinical effectiveness in cure rate and total effective rate is more remarkable.In addition, in treatment group therapeutic process, vital sign is steadily and without serious adverse reactions such as allergy, treatment terminates rear lab index routine blood test, routine urinalysis, electrocardiogram etc. to treatment group patient and carries out statistical procedures, shows no obvious abnormalities.Result shows that the clinical application of we is safely and effectively, is worth studying and applying further.
Claims (9)
1. treat the Chinese medicine composition of reflux esophagitis for one kind, it is characterized in that, its crude drug primarily of following weight portion obtains: Fructus Citri Sarcodactylis 16-20 part, Caulis Bambusae In Taenia 10-14 part, Endoconcha Sepiae 10-12 part, Radix Linderae 8-10 part, Radix Codonopsis 8-10 part, Pericarpium Citri Reticulatae 6-9 part, Fructus Evodiae 10-12 part, Fructus Aurantii 10-12 part, Herba Taraxaci 8-12 part, Lignum Aquilariae Resinatum 6-8 part.
2. a kind of Chinese medicine composition for the treatment of reflux esophagitis as claimed in claim 1, it is characterized in that, its crude drug primarily of following weight portion obtains: Fructus Citri Sarcodactylis 18 parts, Caulis Bambusae In Taenia 12 parts, Endoconcha Sepiae 11 parts, the Radix Linderae 9 parts, Radix Codonopsis 9 parts, Pericarpium Citri Reticulatae 7 parts, Fructus Evodiae 11 parts, Fructus Aurantii 11 parts, Herba Taraxaci 10 parts, Lignum Aquilariae Resinatum 7 parts.
3. a kind of Chinese medicine composition for the treatment of reflux esophagitis as described in claim 1,2, it is characterized in that, described Chinese medicine composition is oral formulations.
4. a kind of Chinese medicine composition for the treatment of reflux esophagitis as claimed in claim 3, it is characterized in that, described oral formulations is tablet, capsule or granule.
5. a kind of Chinese medicine composition for the treatment of reflux esophagitis as claimed in claim 4, it is characterized in that, the preparation method of described tablet has the following steps: take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Each decoction adds water 5 times amount, decocts secondary, each 2 hours, collecting decoction, filters; Filtrate is concentrated into the clear paste that relative density is 1.14 ~ 1.18, and 50 DEG C of cold drying, are ground into fine powder, add appropriate amount of auxiliary materials, compress tablet coating.
6. a kind of Chinese medicine composition for the treatment of reflux esophagitis as claimed in claim 4, it is characterized in that, the preparation method of described capsule has the following steps: take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Each decoction adds water 5 times amount, decocts secondary, each 2 hours, collecting decoction, filters; Filtrate is concentrated into the clear paste that relative density is 1.14 ~ 1.18, and 50 DEG C of cold drying, be ground into middle powder, add appropriate amount of auxiliary materials, mix homogeneously incapsulates.
7. a kind of Chinese medicine composition for the treatment of reflux esophagitis as claimed in claim 4, it is characterized in that, the preparation method of described granule has the following steps: take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Each decoction adds water 5 times amount, decocts secondary, each 2 hours, collecting decoction, filters; Filtrate is concentrated into the clear paste that relative density is 1.14 ~ 1.18, adds appropriate dextrin and sucrose soft material, makes wet granular and crosses 16 mesh sieves, and dry, granulate, sieves again, and pack is packed and be get final product.
8. the purposes of the medicine as described in claim 1,2 in the medicine of preparation treatment reflux esophagitis.
9. the purposes of the medicine as described in claim 1,2 in the medicine of preparation treatment stagnation of QI causing phlegm retention type reflux esophagitis.
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| CN105560480A (en) * | 2016-01-28 | 2016-05-11 | 青岛大学附属医院 | Medicine composition for treating reflux esophagitis and preparation method thereof |
| CN105920372A (en) * | 2016-06-30 | 2016-09-07 | 田引娣 | Medicine for treating reflux esophagitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105560480A (en) * | 2016-01-28 | 2016-05-11 | 青岛大学附属医院 | Medicine composition for treating reflux esophagitis and preparation method thereof |
| CN105920372A (en) * | 2016-06-30 | 2016-09-07 | 田引娣 | Medicine for treating reflux esophagitis |
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Application publication date: 20150708 |