CN103055286B - Traditional Chinese medicine for treating chronic atrophic gastritis and preparation method thereof - Google Patents
Traditional Chinese medicine for treating chronic atrophic gastritis and preparation method thereof Download PDFInfo
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- CN103055286B CN103055286B CN201210576758.0A CN201210576758A CN103055286B CN 103055286 B CN103055286 B CN 103055286B CN 201210576758 A CN201210576758 A CN 201210576758A CN 103055286 B CN103055286 B CN 103055286B
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Abstract
The purpose of the present invention is to provide a traditional Chinese medicine for treating chronic atrophic gastritis and a preparation method thereof, wherein the traditional Chinese medicine includes cassia twig, red ginseng, poria, amomum fruit, alpinia fruit, baked ginger, ginger, cardamom, and prepared pinellia. The traditional Chinese medicine of the present invention has good reversal, alleviating or eliminating effect to intestinal metaplasia pathological changes of chronic atrophic gastritis, and currently, no obvious adverse reactions and side effects are found, so the medicine is safe and reliable. The traditional Chinese medicine of the present invention has good gastric motility promoting effect, and can also be applied to the treatment of patients having functional gastrointestinal disorders with poor gastrointestinal motility, such as the gastroesophageal reflux disease, bile reflux gastritis, functional dyspepsia, diabetic gastroparesis and functional constipation.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine for the treatment of chronic atrophic gastritis and preparation method thereof.
Background technology
Chronic atrophic gastritis (Chronic atrophic gastritis) is one of common disease of stomach.Pathogenic factor has a lot, as the hobby of arteriosclerosis, stomach Insufficience of blood flow, cigarette,wine and tea etc. all easily damages the barrier function of gastric mucosa and causes chronic atrophic gastritis.Clinical manifestation is that Abdeminal pain, belch, stomach poor appetite such as move back at the indigestion symptom.
China's chronic atrophic gastritis canceration incidence rate is about 3%～5%.In the normal gastric mucosa-superficial gastritis-atrophic gastritis-small intestinal type intestinal epithelial metaplasia-large visible peristalsis visible intestinal peristalsis intestinal epithelial metaplasia-atypical hyperplasia-intestinal-type gastric cancer pattern proposing at Correa, intestinal epithelial metaplasia is an important step, and higher with chronic atrophic gastritis intestinal epithelial metaplasia rate, intestinal degree and Mucosal atrophy degree have good concordance.Research finds, the intestinal epithelial metaplasia pathological changes of atrophic gastritis can reverse, alleviates or disappear, and light, moderate intestinal epithelial metaplasia is as treated not in time, can be further development of severe intestinal metaplasia, atypical hyperplasia, even canceration.Therefore patient can produce the feared state of mind, makes progression of disease.Therefore, identifying early and control intestinal epithelial metaplasia is the important step that prevention gastric cancer occurs.
The medicine of doctor trained in Western medicine conventional therapy intestinal epithelial metaplasia at present mainly contains antacid and acid inhibitor, anti-Hp infection, gastric mucosa protective agent, gastro-kinetic agent, spasmolytic, gut hormone class medicine and aid digestion class medicine etc.; but all cure the symptoms, not the disease; can only some symptoms of respite, can not reverse and change raw cell or stoped Normocellularization raw.Chinese patent medicine, as WEIFUCHUN, MOLUO DAN etc. has been applied to the treatment to chronic atrophic gastritis companion intestinal, also has the clinical report of associated treatment effect.But by clinical practice, apply discovery, the clinical efficacy of these Chinese patent medicines is not very good.Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs treatment chronic atrophic gastritis companion intestinalization is with a long history, but because being subject to the restriction of doctor's determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs level and the disunity of differentiation of symptoms and signs for classification of syndrome, has seriously affected its clinical efficacy.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine for the treatment of chronic atrophic gastritis and preparation method thereof, the treatment by Chinese herbs chronic atrophic gastritis for the treatment of chronic atrophic gastritis provided by the present invention is respond well, be particularly suited for treating chronic atrophic gastritis companion intestinal epithelial metaplasia, and in therapeutic process, do not find untoward reaction, safe and reliable.
The Chinese medicine for the treatment of chronic atrophic gastritis of the present invention is to be prepared from by the raw material that comprises following weight portion:
Ramulus Cinnamomi 5～40 Radix Ginseng Rubra 5～40 Poria 5～40
Fructus Amomi 5～40 Fructus Alpiniae Oxyphyllae 5～40 Rhizoma Zingiberis Preparatums 5～40
Rhizoma Zingiberis Recens 10～50 Fructus Amomi Rotundus 5～40 Rhizoma Pinelliae Preparatum 5～40.
The Chinese medicine for the treatment of chronic atrophic gastritis of the present invention, its preferred version is to be prepared from by the raw material that comprises following weight portion:
Ramulus Cinnamomi 10～30 Radix Ginseng Rubra 5～25 Poria 5～25
Fructus Amomi 5～25 Fructus Alpiniae Oxyphyllae 5～25 Rhizoma Zingiberis Preparatums 10～30
Rhizoma Zingiberis Recens 20～40 Fructus Amomi Rotundus 5～25 Rhizoma Pinelliae Preparatum 5～25.
The Chinese medicine for the treatment of chronic atrophic gastritis of the present invention, its further preferred version is to be prepared from by the raw material that comprises following weight portion:
Ramulus Cinnamomi 20 Radix Ginseng Rubra 15 Poria 20
Fructus Amomi 15 Fructus Alpiniae Oxyphyllae 15 Rhizoma Zingiberis Preparatums 20
Rhizoma Zingiberis Recens 30 Fructus Amomi Rotundus 15 Rhizoma Pinelliae Preparatum 15.
The Chinese medicine for the treatment of chronic atrophic gastritis of the present invention, its active component is prepared from by the following method:
Get whole 9 taste medical materials, extracting in water twice, adds the water that is equivalent to 6～10 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 6～10 times of medical material gross weights, extracts 1～3 hour; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.20～1.26, obtains described active component.
The Chinese medicine for the treatment of chronic atrophic gastritis of the present invention, its active component is to be prepared from by following method for optimizing:
Get whole 9 taste medical materials, extracting in water twice, adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 6～8 times of medical material gross weights, extracts 2 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.25, obtains described active component.
The Chinese medicine for the treatment of chronic atrophic gastritis of the present invention, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms.
The Chinese medicine of described treatment chronic atrophic gastritis is as the application of preparation treatment functional gastrointestinal medicine, and Chinese medicine of the present invention can also be used to treat functional gastrointestinal disorder.
In the present invention, Chinese medicine details is as follows:
Ramulus Cinnamomi
This product is the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Spring, Xia Erji gather, and except defoliation, dry, or section are dried.Acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.Function diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Radix Ginseng Rubra
This product is the cultivation product of Araliaceae Radix Ginseng Panax ginseng C. A. Mey. dry root and the rhizomes after steaming.Excavate autumn, cleans, after steaming, dry.Sweet in the mouth, micro-hardship, warm in nature.Return spleen, lung, the heart.Kidney channel.Function strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, nourishing qi to stop.For weak body and prostration, cold extremities faint pulse, QI failing to control blood, metrostaxis.
Poria
This product is On Polyporaceae Poria Poria cocos(Schw.) dry sclerotia of Wolf.More than excavating the 7-9 month, after digging out, remove silt, bank up after " diaphoresis ", spread out and dry in the air to dry tack free, then " diaphoresis ", after extremely now wrinkle, the large portion of internal moisture scatter and disappear for several times repeatedly, dry in the shade, be called " Poria "; Or fresh Poria is pressed to different parts cutting, cloudy in, be called " Cortex Sclerotii Poriae " and " Poria piece ".Sweet in the mouth, light, property is flat.GUIXIN, lung, spleen, kidney channel.Function promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria. phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Fructus Amomi
This product is the dry mature fruit of zingiberaceous plant Fructus Amomi Amomum villosum Lour., green shell sand Amomum villosum Lour. var. xanthioides T. L. Wu et Senjen or SEMEN AMOMI LONGILIGULA Amomum longiligulare T. L. Wu.Summer, two season of autumn gather during fruit maturation, dry or cold drying.Acrid in the mouth, warm in nature.Return spleen, stomach, kidney channel.Function removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Fructus Alpiniae Oxyphyllae
This product is the dry mature fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae Alpinia oxyphylla Miq..Summer, autumn gather while asking fruit by green reddening, and dry or cold drying.Acrid in the mouth, warm in nature.Return spleen, kidney channel.Function warming the kidney controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrhaly takes the photograph saliva.For enuresis due to deficiency of the kidney, frequent micturition, seminal emission nebulousurine, spleen-cold syndrome is had loose bowels, cold type of pain in abdomen, mouthful many salivas.
Rhizoma Zingiberis Preparatum
This product is the Preparation process product of Rhizoma Zingiberis, and Rhizoma Zingiberis is the dry rhizome of zingiber ZingiberofficinaleRose..Acrid in the mouth, hot in nature.Return spleen, stomach, kidney channel.Function warming the meridian for stopping bleeding, warming middle-JIAO to relieve pain.For yang deficiency, lose blood, tell nosebleed metrorrhagia, Deficiency and coldness of spleen and stomach, stomachache is vomited and diarrhoea.
Rhizoma Zingiberis Recens
This product is the fresh rhizome of zingiber Zingiber officinale Rosc..Autumn, two seasons of winter excavate, and remove fibrous root and silt.Acrid in the mouth, slightly warm in nature.Return lung, spleen, stomach warp.The function cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing, solving toxin of fish and crab.For anemofrigid cold, gastrofrigid vomiting, cold-phlegm cough, fish Eriocheir sinensis is poisoning.
Fructus Amomi Rotundus
This product is zingiberaceous plant Fructus Amomi Rotundus Amomum kravanh Pierre ex Gagnep.Or the dry mature fruit of amomum compactum Soland ex Maton Amomum compactum Soland ex Maton.By place of production difference, be divided into " former Fructus Amomi Rotundus " and " Indonesia's Fructus Amomi Rotundus ".Acrid in the mouth, warm in nature.Return lung, spleen, stomach warp.Function removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, appetite-stimulating indigestion-relieving.For turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappear.
Rhizoma Pinelliae Preparatum
This product is the tuber for the aroid Rhizoma Pinelliae (Pinellia ternata (Thunb) Breit.).The dry Preparation process product that form after the soaking with Radix Glycyrrhizae lime liquor of Rhizoma Pinelliae.Acrid in the mouth, warm in nature.Return spleen, stomach, lung meridian.Function drying dampness to eliminate phlegm.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.
Inventor is through the research to chronic atrophic gastritis for many years, and the differentiation of the deficiency of vital energy, the stagnation of QI, cold coagulation, blood stasis, dampness, expectorant knot and comprehensive function have finally caused the generation of this disease.Therefore tonify deficiency dredging collateral, dissipating phlegm and resolving masses is the fundamental law for the treatment of chronic atrophic gastritis and chronic atrophic gastritis companion intestinal.The Ramulus Cinnamomi warming YANG painful abdominal mass that disappears in the present invention, promoting the flow of QI in the collateral by warming the meridian, dispelling dampness and promoting diuresis; During Radix Ginseng Rubra spleen reinforcing is adjusted, inspire temper, help the source of vital function; Poria spleen invigorating dehumidifying; The Fructus Amomi warming middle-JIAO of regulating the flow of vital energy, removing dampness is amusing; The appetizing of Fructus Alpiniae Oxyphyllae warming the spleen; The pain relieving of Rhizoma Zingiberis Preparatum warming middle-JIAO for easing the stomach; Rhizoma Zingiberis Recens warming stomach for dispelling cold, and middle sending down the abnormal ascending QI are the panacea of patient suffering from habitual vomiting; Fructus Amomi Rotundus removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting; Rhizoma Pinelliae Preparatum drying dampness to eliminate phlegm, normalizing the stomach by guiding QI downward.All medicines share, and gather altogether tonify deficiency dredging collateral, the merit of dissipating phlegm and resolving masses.The present invention has good reverse, alleviates or consumption the intestinal epithelial metaplasia pathological changes of chronic atrophic gastritis.Do not find at present obvious untoward reaction and toxic and side effects, safe and reliable.
The present invention has good stomach motility enhancing effect, can also be applied to the low patient for the treatment of functional gastrointestinal disorder companion's digestive tract power, such as gastroesophageal reflux disease, bile reflux gastritis, functional dyspepsia, diabetic gastroparesis and functional constipation etc.
As the clinical test results of embodiment 7 and embodiment 8 shows, treatment by Chinese herbs chronic atrophic gastritis of the present invention has good effect, and effective percentage can reach more than 95%; Chinese medicine of the present invention also has good curative effect for the functional gastroenteritis for the treatment of; And in the clinical process treating, have no toxic and side effects, safe and reliable.
Chinese medicine provided by the invention has overcome the defect of prior art, with respect to prior art, has outstanding substantive distinguishing features and progressive significantly.
The specific embodiment
Embodiment 1
Ramulus Cinnamomi 50g Radix Ginseng Rubra 50g Poria 50g
Fructus Amomi 50g Fructus Alpiniae Oxyphyllae 50g Rhizoma Zingiberis Preparatum 50g
Rhizoma Zingiberis Recens 100g Fructus Amomi Rotundus 50g Rhizoma Pinelliae Preparatum 50g
Get whole 9 taste medical materials, extracting in water twice, adds the water of 3000g for the first time, extracts 1 hour, adds for the second time the water of 3000g, extracts 1 hour; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.20, obtains described active component.
Embodiment 2
Ramulus Cinnamomi 400g Radix Ginseng Rubra 400g Poria 400g
Fructus Amomi 400g Fructus Alpiniae Oxyphyllae 400g Rhizoma Zingiberis Preparatum 400g
Rhizoma Zingiberis Recens 500g Fructus Amomi Rotundus 400g Rhizoma Pinelliae Preparatum 400g.
Get whole 9 taste medical materials, extracting in water twice, adds the water of 37000g for the first time, extracts 3 hours, adds for the second time the water of 37000g, extracts 3 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.26, obtains described active component.
Active component is mixed with appropriate amount of starch and dextrin, granulate, dry, tabletting, obtains tablet of the present invention.
Embodiment 3
Ramulus Cinnamomi 200g Radix Ginseng Rubra 150g Poria 200g
Fructus Amomi 150g Fructus Alpiniae Oxyphyllae 150g Rhizoma Zingiberis Preparatum 200g
Rhizoma Zingiberis Recens 300g Fructus Amomi Rotundus 150g Rhizoma Pinelliae Preparatum 150g
Get whole 9 taste medical materials, extracting in water twice, adds the water of 13200g for the first time, extracts 2 hours, adds for the second time the water of 9900g, extracts 2 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.25, obtains described active component.
Active component is mixed with appropriate sucrose and antiseptic, add water to 1000g, obtain oral liquid of the present invention.
Embodiment 4
Ramulus Cinnamomi 130g Radix Ginseng Rubra 200g Poria 130g
Fructus Amomi 200g Fructus Alpiniae Oxyphyllae 200g Rhizoma Zingiberis Preparatum 130g
Rhizoma Zingiberis Recens 200g Fructus Amomi Rotundus 200g Rhizoma Pinelliae Preparatum 200g
Get whole 9 taste medical materials, extracting in water twice, adds the water of 11130g for the first time, extracts 2 hours, adds for the second time the water of 12720g, extracts 2.5 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.23, obtains described active component.
Active component is mixed with appropriate sucrose, granulation, dry, obtain granule of the present invention.
Embodiment 5
Ramulus Cinnamomi 220g Radix Ginseng Rubra 180g Poria 200g
Fructus Amomi 180g Fructus Alpiniae Oxyphyllae 160g Rhizoma Zingiberis Preparatum 200g
Rhizoma Zingiberis Recens 400g Fructus Amomi Rotundus 250g Rhizoma Pinelliae Preparatum 250g
Get whole 9 taste medical materials, extracting in water twice, adds the water of 18360g for the first time, extracts 1.5 hours, adds for the second time the water of 12240g, extracts 1.8 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.21, obtains described active component.
Active component is put in vacuum drying oven to 70 ℃ and dry, pulverize 100 mesh sieves, add appropriate amount of starch, silicon dioxide, magnesium stearate, granulation, dry, incapsulate, obtain capsule of the present invention.
Embodiment 6
Ramulus Cinnamomi 300g Radix Ginseng Rubra 250g Poria 250g
Fructus Amomi 250g Fructus Alpiniae Oxyphyllae 250g Rhizoma Zingiberis Preparatum 300g
Rhizoma Zingiberis Recens 400g Fructus Amomi Rotundus 250g Rhizoma Pinelliae Preparatum 250g
Get whole 9 taste medical materials, extracting in water twice, adds the water of 17500g for the first time, extracts 2.3 hours, adds for the second time the water of 22500g, extracts 1.4 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.24, obtains described active component.
Active component is put in vacuum drying oven to 70 ℃ and dry, pulverize 100 mesh sieves, add appropriate amount of starch, silicon dioxide, magnesium stearate, granulation, tabletting, obtains tablet of the present invention.
Embodiment 7
The clinical trial situation of Chinese medicine of the present invention:
1, case selection
230 routine patients, according to the sequencing that enters research, adopt table of random number method to be divided at random treatment group 121 example and matched group 109 examples.Treatment group male's 65 examples, women's 56 examples; 25～68 years old age, average (50.22 ± 2.41 years old); The course of disease 3～21 years, average 12.0; Matched group male 60 examples, women's 49 examples; 27～69 years old age, average (49.98+2.55) year; The course of disease 2～23 years, average 11.9.Two groups of sexes, the course of disease, state of an illness weight relatively there are no significant difference (P>0.05), has comparability.
2, diagnostic criteria brief introduction
With reference to related content in the < < gastroenterology > > of Zheng Zhi owner of farmland's volume in 2000, formulate.Exclusion standard: pathological diagnosis has severe intestinal metaplasia, dysplasia or is suspected to have the person of cancerating, endoscope's confirmation merging peptic ulcer or merges the serious primary disease such as the heart, liver, kidney and hemopoietic system, psychotic patient.
3, curative effect determinate standard:
3.1 therapeutic effect of syndrome evaluation criterias are formulated with reference to < < new Chinese medicine guideline of clinical investigations > >.Clinical recovery: symptom, sign disappear or substantially disappear, and syndrome integration reduces >=95%; Effective: symptom, sign are obviously improved, syndrome integration reduces >=70%; Effective: symptom, sign all take a favorable turn, syndrome integration reduces >=30%; Invalid: symptom, sign are all not improved, even increase the weight of, syndrome integration reduces less than 30%.
Note: computing formula (nimodipine method) [integration before (the rear integration of integration-treatment before treatment) ÷ treatment] × 100%.
3.2 chronic atrophic gastritis light, moderate intestinal epithelial metaplasia gastroscope and pathology efficacy assessment standard gastroscope and pathology efficacy assessment standard are formulated with reference to < < preventing precancerous lesion of stomach cancer Preclinic and clinic > >.1. cure: gastroscope and pathologic finding Mucosal atrophy, intestinalization is raw substantially to disappear or becomes superficial gastritis.2. effective: gastroscope and pathologic finding Mucosal atrophy transfer moderate to from severe, or moderate transfers to slightly, and intestinal life simultaneously transfers slightly or slightly transfers to intestinalization to from moderate and disappears; Or Mucosal atrophy transfers to slightly from severe; Or intestinal life transfers intestinalization disappearance to from moderate.3. effective: gastroscope and pathologic finding Mucosal atrophy transfer moderate to from severe, or moderate transfers to slightly; Or intestinal life transfers to slightly from moderate, or slightly transfer intestinalization to and disappear.4. invalid: gastroscope and pathologic finding Mucosal atrophy, intestinalization life are all not improved or worsen.
4, drug use method
4.1 treatment groups are taken the medicine of the embodiment of the present invention 3, and every day twice, each serving the medicine with being equivalent to crude drug amount 80g.
4.2 matched group WEIFUCHUN PIAN (production of Hu Qingyu Pharmaceutical Workshop, Hangzhou), each 4, ante cibum 30, min took, every
Day 3 times.
5, clinical treatment result, gathers with form
Liang group general curative effect comparison of 5.1 tables 1
| Group | n | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 121 | 60 | 30 | 29 | 2 | 98.35* |
| Matched group | 109 | 35 | 22 | 37 | 15 | 86.24 |
Note: with matched group comparison, * P<0.01
Liang group gastroscopy effect comparison of 5.2 tables 2
| Group | n | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 121 | 90 | 18 | 12 | 1 | 99.17▲ |
| Matched group | 109 | 31 | 38 | 29 | 11 | 89.91 |
Note: with matched group comparison, ▲ P<0.01
Liang group pathology curative effect comparison of 5.3 tables 3
| Group | n | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 121 | 49 | 38 | 29 | 5 | 95.87■ |
| Matched group | 109 | 19 | 32 | 36 | 22 | 79.82 |
Note: with matched group comparison, ■ P<0.01
Embodiment 8
1, Liao × ×, female, 57 years old, workman, people from Liuzhou city, Guangxi province, the course of disease 6 years.The hidden distending pain of gastral cavilty portion, accompanies heartburn sense repeatedly.Electronic gastroscope shows: chronic atrophic gastritis.Pathology: many kitchen ranges atrophy companion intestinal.Through Drug therapy of the present invention recovery from illness half a year.
2, Liu × ×, man, 62 years old, individuality, people from Guilin, the course of disease 10 years.Normal feel that gastral cavilty portion distension does not relax, after the meal for very, belch is done frequently, eat receive not good enough.Electronic gastroscope shows: chronic atrophic gastritis companion is rotten to the corn.Pathology: Chronic Moderate gastritis is accompanied the intestinal epithelial metaplasia of many kitchen ranges.Through the party, treat JIUYUE recovery from illness.
3, old × ×, female, 60 years old, retired professor, people from Growth in Meizhou City, Guangdong, the course of disease 7 years.Gastral cavilty portion distending pain repeatedly, when hungry, very, distension does not relax pain after the meal, become thin, shortness of breath and fatigue.Electronic gastroscope shows: chronic atrophic gastritis.Pathology: Chronic Moderate gastritis companion intestinal epithelial metaplasia.Through Drug therapy of the present invention recovery from illness in a year.
4, open × ×, female, retired bank clerk, people from Guangxi Hechi, the course of disease 8.5 years.The gastral cavilty portion distension that takes place frequently, is work after the meal, and belch is done frequently after the meal, becomes thin.Electronic gastroscope shows: chronic atrophic gastritis.Pathology: body of stomach, the end many kitchen ranges atrophy companion intestinal epithelial metaplasia.Diagnosis: 1, functional dyspepsia; 2, chronic atrophic gastritis.Through Drug therapy of the present invention, within 1 year 5 months, reach pathology recovery from illness.
5, old × ×, man, 58 years old, peasant, Laibin, Guangxi Province people, the course of disease 6 years.The gastral cavilty portion of feel throughout the year sense of discomfort, food is received not good enough, glutted after the meal, malaise, insomnia.Electronic gastroscope shows: chronic atrophic gastritis.Pathology: moderate atrophic gastritis accompanied intestinal.Diagnosis: 1, functional dyspepsia; 2, chronic atrophic gastritis.Through Drug therapy of the present invention, after 10 months, reach pathology recovery from illness.
6, king ×, female, 54 years old, individuality, people from Liuzhou city, Guangxi province, 5-year courses.Gastral cavilty portion sense of discomfort after the meal repeatedly, accompanies heartburnly, and belch is done frequently, is off one's feed.Electronic gastroscope shows: chronic atrophic gastritis.Pathology: many kitchen ranges atrophy companion intestinal.Diagnosis: 1, functional dyspepsia; 2, chronic atrophic gastritis.Through Drug therapy of the present invention, reach pathology recovery from illness in August, 1.
Claims (7)
1. treat a Chinese medicine for chronic atrophic gastritis, it is characterized in that it is to be prepared from by the raw material of following weight portion:
Ramulus Cinnamomi 5～40 Radix Ginseng Rubra 5～40 Poria 5～40
Fructus Amomi 5～40 Fructus Alpiniae Oxyphyllae 5～40 Rhizoma Zingiberis Preparatums 5～40
Rhizoma Zingiberis Recens 10～50 Fructus Amomi Rotundus 5～40 Rhizoma Pinelliae Preparatum 5～40.
2. the Chinese medicine for the treatment of chronic atrophic gastritis as claimed in claim 1, is characterized in that it is to be prepared from by the raw material of following weight portion:
Ramulus Cinnamomi 10～30 Radix Ginseng Rubra 5～25 Poria 5～25
Fructus Amomi 5～25 Fructus Alpiniae Oxyphyllae 5～25 Rhizoma Zingiberis Preparatums 10～30
Rhizoma Zingiberis Recens 20～40 Fructus Amomi Rotundus 5～25 Rhizoma Pinelliae Preparatum 5～25.
3. the Chinese medicine for the treatment of chronic atrophic gastritis as claimed in claim 2, is characterized in that it is to be prepared from by the raw material of following weight portion:
Ramulus Cinnamomi 20 Radix Ginseng Rubra 15 Poria 20
Fructus Amomi 15 Fructus Alpiniae Oxyphyllae 15 Rhizoma Zingiberis Preparatums 20
Rhizoma Zingiberis Recens 30 Fructus Amomi Rotundus 15 Rhizoma Pinelliae Preparatum 15.
4. the Chinese medicine for the treatment of chronic atrophic gastritis as claimed in claim 1, is characterized in that its active component is prepared from by the following method:
Get whole 9 taste medical materials, extracting in water twice, adds the water that is equivalent to 6～10 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 6～10 times of medical material gross weights, extracts 1～3 hour; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.20～1.26, obtains described active component.
5. the Chinese medicine for the treatment of chronic atrophic gastritis as claimed in claim 1, is characterized in that its active component is prepared from by the following method:
Get whole 9 taste medical materials, extracting in water twice, adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 6～8 times of medical material gross weights, extracts 2 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.25, obtains described active component.
6. treat a Chinese medicine preparation for chronic atrophic gastritis, comprise the Chinese medicine for the treatment of chronic atrophic gastritis of any one in claim 1～5 and pharmaceutically acceptable carrier.
7. the Chinese medicine of the treatment chronic atrophic gastritis as described in any one in claim 1～5 is as the application of preparation treatment functional gastrointestinal medicine.
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| CN103356943A (en) * | 2013-06-24 | 2013-10-23 | 丁漫漫 | Traditional Chinese medicine for treating gastroparesis syndrome |
| CN103933535A (en) * | 2014-05-15 | 2014-07-23 | 张士金 | Traditional Chinese medicine for treating gastrointestinal diseases, and preparation method thereof |
| CN105056109A (en) * | 2015-07-28 | 2015-11-18 | 张俊平 | Traditional Chinese medicinal composition for treating atrophic gastritis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528408A (en) * | 2003-10-07 | 2004-09-15 | 伟 李 | Kangning Stomach invigorating capsule |
| CN101670079A (en) * | 2008-09-11 | 2010-03-17 | 北京天科仁祥医药科技有限公司 | Chinese medicament for treating chronic atrophic gastritis, preventing and treating gastric cancer |
| CN102716437A (en) * | 2012-05-16 | 2012-10-10 | 王桂琴 | Traditional Chinese medicine composition for atrophic gastritis |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528408A (en) * | 2003-10-07 | 2004-09-15 | 伟 李 | Kangning Stomach invigorating capsule |
| CN101670079A (en) * | 2008-09-11 | 2010-03-17 | 北京天科仁祥医药科技有限公司 | Chinese medicament for treating chronic atrophic gastritis, preventing and treating gastric cancer |
| CN102716437A (en) * | 2012-05-16 | 2012-10-10 | 王桂琴 | Traditional Chinese medicine composition for atrophic gastritis |
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