CN103055286A - A traditional Chinese medicine for treating chronic atrophic gastritis and a preparation method thereof - Google Patents
A traditional Chinese medicine for treating chronic atrophic gastritis and a preparation method thereof Download PDFInfo
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Abstract
The purpose of the present invention is to provide a traditional Chinese medicine for treating chronic atrophic gastritis and a preparation method thereof, wherein the traditional Chinese medicine includes cassia twig, red ginseng, poria, amomum fruit, alpinia fruit, baked ginger, ginger, cardamom, and prepared pinellia. The traditional Chinese medicine of the present invention has good reversal, alleviating or eliminating effect to intestinal metaplasia pathological changes of chronic atrophic gastritis, and currently, no obvious adverse reactions and side effects are found, so the medicine is safe and reliable. The traditional Chinese medicine of the present invention has good gastric motility promoting effect, and can also be applied to the treatment of patients having functional gastrointestinal disorders with poor gastrointestinal motility, such as the gastroesophageal reflux disease, bile reflux gastritis, functional dyspepsia, diabetic gastroparesis and functional constipation.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine for the treatment of chronic atrophic gastritis and preparation method thereof.
Background technology
Chronic atrophic gastritis (Chronic atrophic gastritis) is one of common disease of stomach.Pathogenic factor has a lot, all easily damages the barrier function of gastric mucosa such as hobby of arteriosclerosis, stomach Insufficience of blood flow, cigarette,wine and tea etc. and causes chronic atrophic gastritis.Clinical manifestation is that Abdeminal pain, belch, stomach poor appetite such as move back at the indigestion symptom.
China's chronic atrophic gastritis canceration incidence rate is about 3%～5%.In normal gastric mucosa-superficial gastritis that Correa proposes-atrophic gastritis-small intestinal type intestinal epithelial metaplasia-large visible peristalsis visible intestinal peristalsis intestinal epithelial metaplasia-atypical hyperplasia-intestinal-type gastric cancer pattern, intestinal epithelial metaplasia is an important step, and higher with chronic atrophic gastritis intestinal epithelial metaplasia rate, intestinal degree and Mucosal atrophy degree have preferably concordance.Research finds, the intestinal epithelial metaplasia pathological changes of atrophic gastritis can reverse, alleviates or disappear, and gently, moderate intestinal epithelial metaplasia such as untimely treatment, can be further development of severe intestinal metaplasia, atypical hyperplasia, even canceration.Therefore the patient can produce the feared state of mind, makes progression of disease.Therefore, identifying early and control intestinal epithelial metaplasia is the important step that prevention gastric cancer occurs.
The medicine of at present doctor trained in Western medicine conventional therapy intestinal epithelial metaplasia mainly contains antacid and acid inhibitor, anti-Hp infection, gastric mucosa protective agent, gastro-kinetic agent, spasmolytic, gut hormone class medicine and aid digestion class medicine etc.; but all cure the symptoms, not the disease; can only some symptoms of respite, can not reverse and change living cell or stoped Normocellularization to be given birth to.Chinese patent medicine such as WEIFUCHUN, MOLUO DAN etc. have been applied to the treatment to chronic atrophic gastritis companion intestinal, and the clinical report of associated treatment effect is also arranged.But use discovery by clinical practice, the clinical efficacy of these Chinese patent medicines is not very good.Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs treatment chronic atrophic gastritis companion intestinalization is with a long history, but because of the restriction that is subjected to doctor's determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs level and the disunity of differentiation of symptoms and signs for classification of syndrome, has seriously affected its clinical efficacy.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine for the treatment of chronic atrophic gastritis and preparation method thereof, the treatment by Chinese herbs chronic atrophic gastritis for the treatment of chronic atrophic gastritis provided by the present invention is respond well, be particularly suited for treating chronic atrophic gastritis companion intestinal epithelial metaplasia, and in therapeutic process, do not find untoward reaction, safe and reliable.
The Chinese medicine for the treatment of chronic atrophic gastritis of the present invention is to be prepared from by the raw material that comprises following weight portion:
Ramulus Cinnamomi 5～40 Radix Ginseng Rubra 5～40 Poria 5～40
Fructus Amomi 5～40 Fructus Alpiniae Oxyphyllae 5～40 Rhizoma Zingiberis Preparatums 5～40
Rhizoma Zingiberis Recens 10～50 Fructus Amomi Rotunduss 5～40 Rhizoma Pinelliae Preparatum 5～40.
The Chinese medicine for the treatment of chronic atrophic gastritis of the present invention, its preferred version are to be prepared from by the raw material that comprises following weight portion:
Ramulus Cinnamomi 10～30 Radix Ginseng Rubra 5～25 Poria 5～25
Fructus Amomi 5～25 Fructus Alpiniae Oxyphyllae 5～25 Rhizoma Zingiberis Preparatums 10～30
Rhizoma Zingiberis Recens 20～40 Fructus Amomi Rotunduss 5～25 Rhizoma Pinelliae Preparatum 5～25.
The Chinese medicine for the treatment of chronic atrophic gastritis of the present invention, its further preferred version is to be prepared from by the raw material that comprises following weight portion:
Ramulus Cinnamomi 20 Radix Ginseng Rubra 15 Poria 20
Fructus Amomi 15 Fructus Alpiniae Oxyphyllae 15 Rhizoma Zingiberis Preparatums 20
Rhizoma Zingiberis Recens 30 Fructus Amomi Rotunduss 15 Rhizoma Pinelliae Preparatum 15.
The Chinese medicine for the treatment of chronic atrophic gastritis of the present invention, its active component is prepared from by the following method:
Get whole 9 flavor medical materials, extracting in water twice adds the water that is equivalent to 6～10 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 6～10 times of medical material gross weights, extracts 1～3 hour; Merge extractive liquid,, relative density is 1.20～1.26 extractum when being concentrated into 80 ℃, namely gets described active component.
The Chinese medicine for the treatment of chronic atrophic gastritis of the present invention, its active component are to be prepared from by following method for optimizing:
Get whole 9 flavor medical materials, extracting in water twice adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 6～8 times of medical material gross weights, extracts 2 hours; Merge extractive liquid,, relative density is 1.25 extractum when being concentrated into 80 ℃, namely gets described active component.
The Chinese medicine for the treatment of chronic atrophic gastritis of the present invention can cooperate with pharmaceutically acceptable carrier, makes various common dosage forms.
The Chinese medicine of described treatment chronic atrophic gastritis is as the application of preparation treatment functional gastrointestinal medicine, and Chinese medicine of the present invention can also be used to treat functional gastrointestinal disorder.
The Chinese medicine details is as follows among the present invention:
Ramulus Cinnamomi
This product is the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Spring, Xia Erji gather, and except defoliation, dry, or section are dried.Acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.Function diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Be used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Radix Ginseng Rubra
This product is dry root and the rhizome of cultivation product after steaming of Araliaceae Radix Ginseng Panax ginseng C. A. Mey..Excavate autumn, clean, and after steaming, drying.Sweet in the mouth, little hardship, warm in nature.Return spleen, lung, the heart.Kidney channel.The function strongly invigorating primordial QI, multiple arteries and veins takes off nourishing qi to stop admittedly.Be used for weak body and prostration, cold extremities faint pulse, QI failing to control blood, metrostaxis.
Poria
This product is On Polyporaceae Poria Poria cocos(Schw.) dry sclerotia of Wolf.More than excavating the 7-9 month, remove silt after digging out, after bank up " diaphoresis ", spread out and dry in the air to dry tack free, again " diaphoresis " after extremely now wrinkle, large of internal moisture are scattered and disappeared for several times repeatedly, dries in the shade, and is called " Poria is individual "; Or bright Poria pressed the different parts cutting, cloudy in, be called " Cortex Sclerotii Poriae " and reach " Poria piece ".Sweet in the mouth, light, property is flat.GUIXIN, lung, spleen, kidney channel.The function promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming.Be used for the edema oliguria. the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.
Fructus Amomi
This product is the dry mature fruit of zingiberaceous plant Fructus Amomi Amomum villosum Lour., green shell sand Amomum villosum Lour. var. xanthioides T. L. Wu et Senjen or SEMEN AMOMI LONGILIGULA Amomum longiligulare T. L. Wu.Summer, two season of autumn gather during fruit maturation, dry or cold drying.Acrid in the mouth, warm in nature.Return spleen, stomach, kidney channel.Function removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.Be used for turbid damp obstructing in middle-JIAO, the gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Fructus Alpiniae Oxyphyllae
This product is the dry mature fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae Alpinia oxyphylla Miq..Summer, autumn gather when asking fruit by green reddening, and dry or cold drying.Acrid in the mouth, warm in nature.Return spleen, kidney channel.Function warming the kidney controlling nocturnal emission with astringent drugs reducing urination is warming spleen and stopping diarrhaly taken the photograph saliva.Be used for enuresis due to deficiency of the kidney, frequent micturition, the seminal emission nebulousurine, spleen-cold syndrome is had loose bowels, cold type of pain in the abdomen, mouthful many salivas.
Rhizoma Zingiberis Preparatum
This product is the Preparation process product of Rhizoma Zingiberis, and Rhizoma Zingiberis is the dry rhizome of zingiber ZingiberofficinaleRose..Acrid in the mouth, hot in nature.Return spleen, stomach, kidney channel.The function warming the meridian for stopping bleeding, warming middle-JIAO to relieve pain.Be used for yang deficiency and lose blood, tell the nosebleed metrorrhagia, Deficiency and coldness of spleen and stomach, stomachache is vomited and diarrhoea.
Rhizoma Zingiberis Recens
This product is the fresh rhizome of zingiber Zingiber officinale Rosc..Autumn, two seasons of winter excavate, and remove fibrous root and silt.Acrid in the mouth, slightly warm in nature.Return lung, spleen, stomach warp.The function cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing, solving toxin of fish and crab.Be used for anemofrigid cold, gastrofrigid vomiting, the cold-phlegm cough, the fish Eriocheir sinensis poisons.
Fructus Amomi Rotundus
This product is zingiberaceous plant Fructus Amomi Rotundus Amomum kravanh Pierre ex Gagnep.Or the dry mature fruit of amomum compactum Soland ex Maton Amomum compactum Soland ex Maton.Be divided into " former Fructus Amomi Rotundus " and " Indonesia's Fructus Amomi Rotundus " by place of production difference.Acrid in the mouth, warm in nature.Return lung, spleen, stomach warp.Function removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, appetite-stimulating indigestion-relieving.Be used for turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, the cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappear.
Rhizoma Pinelliae Preparatum
This product is for being the tuber of the aroid Rhizoma Pinelliae (Pinellia ternata (Thunb) Breit.).The Preparation process product that drying forms after the soaking with the Radix Glycyrrhizae lime liquor of Rhizoma Pinelliae.Acrid in the mouth, warm in nature.Return spleen, stomach, lung meridian.The function drying dampness to eliminate phlegm.Be used for the abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.
The inventor through for many years to the research of chronic atrophic gastritis, the differentiation of the deficiency of vital energy, the stagnation of QI, cold coagulation, blood stasis, wet resistance, expectorant knot and comprehensive function finally caused should disease generation.So the tonify deficiency collateral dredging, dissipating phlegm and resolving masses is the fundamental law for the treatment of chronic atrophic gastritis and chronic atrophic gastritis companion intestinal.The Ramulus Cinnamomi warming YANG painful abdominal mass that disappears among the present invention, promoting the flow of QI in the collateral by warming the meridian, dispelling dampness and promoting diuresis; During the Radix Ginseng Rubra spleen reinforcing is transferred, inspire temper, help the source of vital function; Poria spleen invigorating dehumidifying; The Fructus Amomi warming middle-JIAO of regulating the flow of vital energy, removing dampness is amusing; The appetizing of Fructus Alpiniae Oxyphyllae warming the spleen; The pain relieving of Rhizoma Zingiberis Preparatum warming middle-JIAO for easing the stomach; Rhizoma Zingiberis Recens warming stomach for dispelling cold, and middle sending down the abnormal ascending QI are the panacea of patient suffering from habitual vomiting; Fructus Amomi Rotundus removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting; The Rhizoma Pinelliae Preparatum drying dampness to eliminate phlegm, normalizing the stomach by guiding QI downward.All medicines share, and gather altogether the tonify deficiency collateral dredging, the merit of dissipating phlegm and resolving masses.The present invention has good reverse, alleviates or consumption the intestinal epithelial metaplasia pathological changes of chronic atrophic gastritis.Do not find at present obvious untoward reaction and toxic and side effects, safe and reliable.
The present invention has good stomach motility enhancing effect, can also be applied to treat the low patient of functional gastrointestinal disorder companion's digestive tract power, such as gastroesophageal reflux disease, bile reflux gastritis, functional dyspepsia, diabetic gastroparesis and functional constipation etc.
Clinical test results such as embodiment 7 and embodiment 8 shows, treatment by Chinese herbs chronic atrophic gastritis of the present invention has preferably effect, and effective percentage can reach more than 95%; Chinese medicine of the present invention also has preferably curative effect for the functional gastroenteritis for the treatment of; And execute in the process of controlling clinical, have no toxic and side effects, safe and reliable.
Chinese medicine provided by the invention has overcome the defective of prior art, has outstanding substantive distinguishing features and progressive significantly with respect to prior art.
The specific embodiment
Embodiment 1
Ramulus Cinnamomi 50g Radix Ginseng Rubra 50g Poria 50g
Fructus Amomi 50g Fructus Alpiniae Oxyphyllae 50g Rhizoma Zingiberis Preparatum 50g
Rhizoma Zingiberis Recens 100g Fructus Amomi Rotundus 50g Rhizoma Pinelliae Preparatum 50g
Get whole 9 flavor medical materials, extracting in water twice, the water that add 3000g the first time extracted 1 hour, added the water of 3000g for the second time, extracted 1 hour; Merge extractive liquid,, relative density is 1.20 extractum when being concentrated into 80 ℃, namely gets described active component.
Embodiment 2
Ramulus Cinnamomi 400g Radix Ginseng Rubra 400g Poria 400g
Fructus Amomi 400g Fructus Alpiniae Oxyphyllae 400g Rhizoma Zingiberis Preparatum 400g
Rhizoma Zingiberis Recens 500g Fructus Amomi Rotundus 400g Rhizoma Pinelliae Preparatum 400g.
Get whole 9 flavor medical materials, extracting in water twice, the water that add 37000g the first time extracted 3 hours, added the water of 37000g for the second time, extracted 3 hours; Merge extractive liquid,, relative density is 1.26 extractum when being concentrated into 80 ℃, namely gets described active component.
Active component is mixed with appropriate amount of starch and dextrin, granulate, drying, tabletting namely gets tablet of the present invention.
Embodiment 3
Ramulus Cinnamomi 200g Radix Ginseng Rubra 150g Poria 200g
Fructus Amomi 150g Fructus Alpiniae Oxyphyllae 150g Rhizoma Zingiberis Preparatum 200g
Rhizoma Zingiberis Recens 300g Fructus Amomi Rotundus 150g Rhizoma Pinelliae Preparatum 150g
Get whole 9 flavor medical materials, extracting in water twice, the water that add 13200g the first time extracted 2 hours, added the water of 9900g for the second time, extracted 2 hours; Merge extractive liquid,, relative density is 1.25 extractum when being concentrated into 80 ℃, namely gets described active component.
Active component is mixed with an amount of sucrose and antiseptic, add water to 1000g, namely get oral liquid of the present invention.
Embodiment 4
Ramulus Cinnamomi 130g Radix Ginseng Rubra 200g Poria 130g
Fructus Amomi 200g Fructus Alpiniae Oxyphyllae 200g Rhizoma Zingiberis Preparatum 130g
Rhizoma Zingiberis Recens 200g Fructus Amomi Rotundus 200g Rhizoma Pinelliae Preparatum 200g
Get whole 9 flavor medical materials, extracting in water twice, the water that add 11130g the first time extracted 2 hours, added the water of 12720g for the second time, extracted 2.5 hours; Merge extractive liquid,, relative density is 1.23 extractum when being concentrated into 80 ℃, namely gets described active component.
Active component is mixed with an amount of sucrose, granulation, drying namely gets granule of the present invention.
Embodiment 5
Ramulus Cinnamomi 220g Radix Ginseng Rubra 180g Poria 200g
Fructus Amomi 180g Fructus Alpiniae Oxyphyllae 160g Rhizoma Zingiberis Preparatum 200g
Rhizoma Zingiberis Recens 400g Fructus Amomi Rotundus 250g Rhizoma Pinelliae Preparatum 250g
Get whole 9 flavor medical materials, extracting in water twice, the water that add 18360g the first time extracted 1.5 hours, added the water of 12240g for the second time, extracted 1.8 hours; Merge extractive liquid,, relative density is 1.21 extractum when being concentrated into 80 ℃, namely gets described active component.
Active component is put 70 ℃ of dryings in the vacuum drying oven, pulverized 100 mesh sieves, add appropriate amount of starch, silicon dioxide, magnesium stearate, granulation, drying incapsulates, and namely gets capsule of the present invention.
Embodiment 6
Ramulus Cinnamomi 300g Radix Ginseng Rubra 250g Poria 250g
Fructus Amomi 250g Fructus Alpiniae Oxyphyllae 250g Rhizoma Zingiberis Preparatum 300g
Rhizoma Zingiberis Recens 400g Fructus Amomi Rotundus 250g Rhizoma Pinelliae Preparatum 250g
Get whole 9 flavor medical materials, extracting in water twice, the water that add 17500g the first time extracted 2.3 hours, added the water of 22500g for the second time, extracted 1.4 hours; Merge extractive liquid,, relative density is 1.24 extractum when being concentrated into 80 ℃, namely gets described active component.
Active component is put 70 ℃ of dryings in the vacuum drying oven, pulverized 100 mesh sieves, add appropriate amount of starch, silicon dioxide, magnesium stearate, granulation, tabletting namely gets tablet of the present invention.
Embodiment 7
The clinical trial situation of Chinese medicine of the present invention:
1, case is selected
230 routine patients adopt the table of random number method to be divided at random treatment group 121 example and matched group 109 examples according to the sequencing that enters research.Treatment group male's 65 examples, women's 56 examples; 25～68 years old age, average (50.22 ± 2.41 years old); The course of disease 3～21 years, average 12.0; Matched group male 60 examples, women's 49 examples; 27～69 years old age, average (49.98+2.55) year; The course of disease 2～23 years, average 11.9.Two groups of sexes, the course of disease, state of an illness weight relatively there are no significant difference (P〉0.05), have comparability.
2, diagnostic criteria brief introduction
Formulate with reference to related content in " gastroenterology " of Zheng Zhi owner of farmland's volume in 2000.Exclusion standard: pathological diagnosis has severe intestinal metaplasia, dysplasia or is suspected to have the person of cancerating, endoscope's confirmation merging peptic ulcer or merges the serious primary disease such as the heart, liver, kidney and hemopoietic system, psychotic patients.
3, curative effect determinate standard:
3.1 the therapeutic effect of syndrome evaluation criteria is formulated with reference to " new Chinese medicine guideline of clinical investigations ".Clinical recovery: symptom, sign disappear or basic the disappearance, and the syndrome integration reduces 〉=95%; Produce effects: symptom, sign are obviously improved, and the syndrome integration reduces 〉=70%; Effectively: symptom, sign all take a favorable turn, and the syndrome integration reduces 〉=30%; Invalid: all without obviously improving, even increase the weight of, the syndrome integration reduces less than 30% for symptom, sign.
Annotate: computing formula (nimodipine method) [integration before (integration after integration before the treatment-treatment) ÷ treatment] * 100%.
3.2 chronic atrophic gastritis and light, moderate intestinal epithelial metaplasia gastroscope and pathology efficacy assessment standard gastroscope and pathology efficacy assessment standard are formulated with reference to " preventing precancerous lesion of stomach cancer Preclinic and clinic ".1. cure: gastroscope and pathologic finding Mucosal atrophy, the intestinalization life substantially disappears or becomes superficial gastritis.2. produce effects: gastroscope and pathologic finding Mucosal atrophy transfer moderate to from severe, or moderate transfers to slightly, and simultaneously intestinal life transfers slightly or slightly transfer to the intestinal disappearance to from moderate; Or Mucosal atrophy transfers to slightly from severe; Or the intestinal life transfers the intestinal disappearance to from moderate.3. effective: gastroscope and pathologic finding Mucosal atrophy transfer moderate to from severe, or moderate transfers to slightly; Or the intestinal life transfers to slightly from moderate, or slightly transfers the intestinal disappearance to.4. invalid: gastroscope and pathologic finding Mucosal atrophy, intestinalization are given birth to all without obviously improving or worsening.
4, drug use method
4.1 treatment group is taken the medicine of the embodiment of the invention 3, every day twice is each serving using the medicine that is equivalent to crude drug amount 80g.
4.2 matched group WEIFUCHUN PIAN (production of Hu Qingyu Pharmaceutical Workshop, Hangzhou), each 4, ante cibum 30, min took, and is every
Day 3 times.
5, the clinical treatment result gathers with form
5.1 table 1 liang group general curative effect relatively
| Group | n | Cure | Produce effects | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 121 | 60 | 30 | 29 | 2 | 98.35* |
| Matched group | 109 | 35 | 22 | 37 | 15 | 86.24 |
Annotate: compare * P＜0.01 with matched group
5.2 table 2 liang group gastroscopy effect relatively
| Group | n | Cure | Produce effects | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 121 | 90 | 18 | 12 | 1 | 99.17▲ |
| Matched group | 109 | 31 | 38 | 29 | 11 | 89.91 |
Annotate: compare ▲ P＜0.01 with matched group
5.3 table 3 liang group pathology curative effect relatively
| Group | n | Cure | Produce effects | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 121 | 49 | 38 | 29 | 5 | 95.87■ |
| Matched group | 109 | 19 | 32 | 36 | 22 | 79.82 |
Annotate: compare ■ P＜0.01 with matched group
Embodiment 8
1, Liao * *, woman, 57 years old, workman, Liuzhou city, Guangxi province people, the course of disease 6 years.The hidden distending pain of gastral cavilty section is accompanied heartburn sense repeatedly.Electronic gastroscope shows: chronic atrophic gastritis.Pathology: many kitchen ranges atrophy companion intestinal.Through Drug therapy of the present invention recovery from illness half a year.
2, Liu * *, man, 62 years old, individuality, people from Guilin, the course of disease 10 years.Normal feel that gastral cavilty section distension does not relax, after the meal for very, belch is done frequently, eat receive not good enough.Electronic gastroscope shows: the chronic atrophic gastritis companion is rotten to the corn.Pathology: Chronic Moderate gastritis is accompanied the intestinal epithelial metaplasia of many kitchen ranges.Treat the JIUYUE recovery from illness through the party.
3, old * *, woman, 60 years old, retired professor, Growth in Meizhou City, Guangdong people, the course of disease 7 years.Gastral cavilty section distending pain repeatedly, when hungry pain very, then distension does not relax after the meal, becomes thin shortness of breath and fatigue.Electronic gastroscope shows: chronic atrophic gastritis.Pathology: Chronic Moderate gastritis companion intestinal epithelial metaplasia.Through Drug therapy of the present invention recovery from illness in a year.
4, open * *, woman, retired bank clerk, people from Guangxi Hechi, the course of disease 8.5 years.The gastral cavilty section distension that takes place frequently is work after the meal, and belch is done frequently after the meal, becomes thin.Electronic gastroscope shows: chronic atrophic gastritis.Pathology: body of stomach, the end many kitchen ranges atrophy companion intestinal epithelial metaplasia.Diagnosis: 1, functional dyspepsia; 2, chronic atrophic gastritis.Reached the pathology recovery from illness in 1 year 5 months through Drug therapy of the present invention.
5, old * *, man, 58 years old, peasant, Laibin, Guangxi Province people, the course of disease 6 years.Feel gastral cavilty section sense of discomfort, food is received not good enough, glutted after the meal, malaise, insomnia throughout the year.Electronic gastroscope shows: chronic atrophic gastritis.Pathology: moderate atrophic gastritis accompanied intestinal.Diagnosis: 1, functional dyspepsia; 2, chronic atrophic gastritis.Reach the pathology recovery from illness after 10 months through Drug therapy of the present invention.
6, the king *, woman, 54 years old, individuality, Liuzhou city, Guangxi province people, 5-year courses.Gastral cavilty section sense of discomfort is after the meal repeatedly accompanied heartburnly, and belch is done frequently, is off one's feed.Electronic gastroscope shows: chronic atrophic gastritis.Pathology: many kitchen ranges atrophy companion intestinal.Diagnosis: 1, functional dyspepsia; 2, chronic atrophic gastritis.Reach the pathology recovery from illness in August, 1 through Drug therapy of the present invention.
Claims (7)
1. Chinese medicine for the treatment of chronic atrophic gastritis is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Ramulus Cinnamomi 5～40 Radix Ginseng Rubra 5～40 Poria 5～40
Fructus Amomi 5～40 Fructus Alpiniae Oxyphyllae 5～40 Rhizoma Zingiberis Preparatums 5～40
Rhizoma Zingiberis Recens 10～50 Fructus Amomi Rotunduss 5～40 Rhizoma Pinelliae Preparatum 5～40.
2. the Chinese medicine for the treatment of chronic atrophic gastritis as claimed in claim 1 is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Ramulus Cinnamomi 10～30 Radix Ginseng Rubra 5～25 Poria 5～25
Fructus Amomi 5～25 Fructus Alpiniae Oxyphyllae 5～25 Rhizoma Zingiberis Preparatums 10～30
Rhizoma Zingiberis Recens 20～40 Fructus Amomi Rotunduss 5～25 Rhizoma Pinelliae Preparatum 5～25.
3. the Chinese medicine for the treatment of chronic atrophic gastritis as claimed in claim 2 is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Ramulus Cinnamomi 20 Radix Ginseng Rubra 15 Poria 20
Fructus Amomi 15 Fructus Alpiniae Oxyphyllae 15 Rhizoma Zingiberis Preparatums 20
Rhizoma Zingiberis Recens 30 Fructus Amomi Rotunduss 15 Rhizoma Pinelliae Preparatum 15.
4. the Chinese medicine for the treatment of chronic atrophic gastritis as claimed in claim 1 is characterized in that its active component is prepared from by the following method:
Get whole 9 flavor medical materials, extracting in water twice adds the water that is equivalent to 6～10 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 6～10 times of medical material gross weights, extracts 1～3 hour; Merge extractive liquid,, relative density is 1.20～1.26 extractum when being concentrated into 80 ℃, namely gets described active component.
5. the Chinese medicine for the treatment of chronic atrophic gastritis as claimed in claim 1 is characterized in that its active component is prepared from by the following method:
Get whole 9 flavor medical materials, extracting in water twice adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 6～8 times of medical material gross weights, extracts 2 hours; Merge extractive liquid,, relative density is 1.25 extractum when being concentrated into 80 ℃, namely gets described active component.
6. a Chinese medicine preparation for the treatment of chronic atrophic gastritis comprises the Chinese medicine of each treatment chronic atrophic gastritis in the claim 1～5 and pharmaceutically acceptable carrier.
7. treat the application of functional gastrointestinal medicine as preparation such as the Chinese medicine of each described treatment chronic atrophic gastritis in the claim 1～5.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356943A (en) * | 2013-06-24 | 2013-10-23 | 丁漫漫 | Traditional Chinese medicine for treating gastroparesis syndrome |
| CN103933535A (en) * | 2014-05-15 | 2014-07-23 | 张士金 | Traditional Chinese medicine for treating gastrointestinal diseases, and preparation method thereof |
| CN105056109A (en) * | 2015-07-28 | 2015-11-18 | 张俊平 | Traditional Chinese medicinal composition for treating atrophic gastritis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528408A (en) * | 2003-10-07 | 2004-09-15 | 伟 李 | Kangning Stomach invigorating capsule |
| CN101670079A (en) * | 2008-09-11 | 2010-03-17 | 北京天科仁祥医药科技有限公司 | Chinese medicament for treating chronic atrophic gastritis, preventing and treating gastric cancer |
| CN102716437A (en) * | 2012-05-16 | 2012-10-10 | 王桂琴 | Traditional Chinese medicine composition for atrophic gastritis |
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2012
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528408A (en) * | 2003-10-07 | 2004-09-15 | 伟 李 | Kangning Stomach invigorating capsule |
| CN101670079A (en) * | 2008-09-11 | 2010-03-17 | 北京天科仁祥医药科技有限公司 | Chinese medicament for treating chronic atrophic gastritis, preventing and treating gastric cancer |
| CN102716437A (en) * | 2012-05-16 | 2012-10-10 | 王桂琴 | Traditional Chinese medicine composition for atrophic gastritis |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356943A (en) * | 2013-06-24 | 2013-10-23 | 丁漫漫 | Traditional Chinese medicine for treating gastroparesis syndrome |
| CN103933535A (en) * | 2014-05-15 | 2014-07-23 | 张士金 | Traditional Chinese medicine for treating gastrointestinal diseases, and preparation method thereof |
| CN105056109A (en) * | 2015-07-28 | 2015-11-18 | 张俊平 | Traditional Chinese medicinal composition for treating atrophic gastritis |
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| CN103055286B (en) | 2014-05-07 |
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