CN103055257B - Traditional Chinese medicine for treating chronic gastritis and preparation method thereof - Google Patents

Abstract

The invention aims to provide a traditional Chinese medicine for treating chronic gastritis and a preparation method thereof. The traditional Chinese medicine comprises coptis, root of large-flowered skullcap, dried orange peel, prepared pinellia tuber, Poria cocos, bighead atractylodes rhizome, coix seed, honey-fried licorice root, curcuma rhizome, hairyvein agrimony, madder, cuttlebone and Zhejiang fritillaria bulb. The traditional Chinese medicine provided by the invention mainly clears heat, drains dampness, harmonizes the stomach and relieves pains, and comprehensive adjustment of all the internal organs is carried out; deficiency and excess are clearly differentiated, and tonifying, clearing and surrendering are organically combined together, which is a combined therapy for comprehensive adjustment of a human body. The traditional Chinese medicine for treating chronic gastritis has a good therapeutic effect on chronic gastritis and is particularly applicable to treatment of damp-heat type chronic gastritis; no adverse reaction is spotted in treatment process, and the traditional Chinese medicine is safe and reliable.

Description

Chinese medicine for the treatment of chronic gastritis and preparation method thereof

Technical field

The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine for the treatment of chronic gastritis and preparation method thereof.

Background technology

Chronic gastritis (chronic gestritis) means chronic inflammatory disease or the atrophic lesion of the gastric mucosa that different pathogeny causes, after its essence is that gastric epithelial suffers repeatedly to damage, due to the special regeneration capacity of mucosa, so that mucosa is reconstructed, and finally cause the atrophy of irreversible intrinsic gastric gland body, even disappear.Primary disease is very common, accounts for and accepts gastroscopy patient's 80～90%, and male, more than women, increases gradually with age growth sickness rate.The pathological change of chronic gastritis, is confined to mucous layer substantially, therefore strictly says and should be referred to as " chronic gastric mucositis " or " gastric mucosa disease ".According to the record of Schindler, " chronic gastritis " is that first Stahl proposed in 1728, constantly reports to some extent thereafter.But be there is all the time to difference in this diagnosis.Especially after Cruveilhier in 1830 finds gastric ulcer, for the patient who has epigastrium pain, be often diagnosed as Peptic Ulcers or stomach neurosis and do not diagnose gastritis.

The main clinical manifestation of chronic gastritis is Upper abdominal pain, feeling of repletion, heating installation, feel sick, acid regurgitation etc.The cause of disease of chronic gastritis is many to being invaded by exogenous pathogen, temperament and interest internal injury, eating and drinking without temperance and have a delicate constitution etc. relevant.Along with the raising of people's living standard, the quickening of rhythm of life and the increase of operating pressure.The sickness rate of chronic gastritis is ascendant trend year by year.Modern medicine understanding, chronic gastritis mainly infects caused gastric mucosa chronic inflammatory disease by stomach Helicobacter pylori (H. pylori), most take gastric antrum as main full gastritis, gastric mucosa layer is take lymphocyte and plasmocyte infiltrating as main, and the some patients were later stage can show as body of gland atrophy and change raw.China H. pylori infection population estimates 50% ~ 70%, and infection rate has and increase the trend raising with the age, estimates that accordingly China adult chronic gastritis prevalence is at least more than 50%.

Damp-heat syndrome is the common disease of tcm clinical practice, along with the change of current spectrum of disease, and the variation of people's body constitution and dietary structure, damp-heat syndrome is more and more common.To the clinical studies show of damp-heat syndrome in the spleen-stomach disease excess syndrome, in chronic gastritis, syndrome of dampness-heat of spleen and stomach accounts for first place.The key of chronic gastritis will " be prevented and treated ", Patients with Chronic Gastritis is generally being deposited in even Relapse rate outbreak decades of several years more than ten years, even progress causes peptic ulcer, gastric cancer, bad when symptom fashion, maintenance drug therapy curative effect is limited, even hospitalization, and effect is undesirable, can not get radical cure, its reason is not fundamentally treated.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine for the treatment of chronic gastritis and preparation method thereof, the treatment by Chinese herbs chronic gastritis for the treatment of chronic gastritis provided by the present invention is respond well, especially be applicable to the chronic gastritis for the treatment of damp-heat type, and in therapeutic process, do not find untoward reaction, safe and reliable.

The Chinese medicine for the treatment of chronic gastritis of the present invention is to be prepared from by the raw material that comprises following weight portion:

Rhizoma Coptidis 3～20 Radix Scutellariae 5～40 Pericarpium Citri Reticulatae 5～40 Rhizoma Pinelliae Preparatum 5～40

Poria 10～50 Rhizoma Atractylodis Macrocephalae 10～50 Semen Coicis 20～60 Radix Glycyrrhizae Preparata 5～40

Rhizoma Curcumae 10～50 Herba Agrimoniae 10～50 Radix Rubiae 2～15 Endoconcha Sepiaes 20～60

Bulbus Fritillariae Thunbergii 5～40.

The Chinese medicine for the treatment of chronic gastritis of the present invention, its preferred version is to be prepared from by the raw material that comprises following weight portion:

Rhizoma Coptidis 5～15 Radix Scutellariae 10～30 Pericarpium Citri Reticulatae 10～30 Rhizoma Pinelliae Preparatum 10～30

Poria 20～40 Rhizoma Atractylodis Macrocephalae 20～40 Semen Coicis 30～50 Radix Glycyrrhizae Preparata 10～30

Rhizoma Curcumae 20～40 Herba Agrimoniae 20～40 Radix Rubiae 3～9 Endoconcha Sepiaes 30～50

Bulbus Fritillariae Thunbergii 10～30.

The Chinese medicine for the treatment of chronic gastritis of the present invention, its further preferred version is to be prepared from by the raw material that comprises following weight portion:

Rhizoma Coptidis 8 Radix Scutellariae 20 Pericarpium Citri Reticulatae 20 Rhizoma Pinelliae Preparatum 24

Poria 30 Rhizoma Atractylodis Macrocephalae 30 Semen Coicis 40 Radix Glycyrrhizae Preparata 20

Rhizoma Curcumae 30 Herba Agrimoniae 30 Radix Rubiae 6 Endoconcha Sepiaes 40

Bulbus Fritillariae Thunbergii 20.

The Chinese medicine for the treatment of chronic gastritis of the present invention, its active component is prepared from by the following method:

Get whole 13 taste medical materials, extracting in water twice, adds the water that is equivalent to 6～12 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 6～12 times of medical material gross weights, extracts 1～3 hour; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.20～1.26, adding ethanol to the concentration of volume percent containing alcohol amount is 50%～60%, stir even, leave standstill 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.22～1.30, obtains described active component.

The Chinese medicine for the treatment of chronic gastritis of the present invention, its active component is to be prepared from by following method for optimizing:

Get whole 13 taste medical materials, extracting in water twice, adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 8～10 times of medical material gross weights, extracts 2 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.23, adding ethanol to the concentration of volume percent containing alcohol amount is 56%, stir even, leave standstill 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.26, obtains described active component.

The Chinese medicine for the treatment of chronic gastritis of the present invention, its capsule is prepared from by the following method: get whole 13 taste medical materials, clean, drying and sterilizing, pulverizes, and crosses 80 orders～l20 mesh sieve, incapsulates, and to obtain final product.

The Chinese medicine for the treatment of chronic gastritis of the present invention, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms.

In the present invention, Chinese medicine details is as follows:

Rhizoma Coptidis

This product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis Coplis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall Coptisteeta Wall..Practise respectively title " taste connects ", " refined company ", " Coptis Teeta Wall " for above three kinds.Dig autumn, removes fibrous root and silt, dry, hits residual fibrous root.Bitter in the mouth, cold in nature.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, palpitation and uneasiness, heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, and carbuncle is treated skin ulcer; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually damp and hot middle resistance, feeling of fullness vomiting for cold and heat.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

Radix Scutellariae

This product is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Spring, Qiu Erji excavate, and remove fibrous root and silt, hit rough bark after solarization, dry.Bitter in the mouth, cold in nature.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Function heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Pericarpium Citri Reticulatae

This product is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Medical material is divided into " Pericarpium Citri Reticulatae " and " Pericarpium citri reticuatae chachiensis ".Pluck mature fruit, strip peel, dry or cold drying.Bitter in the mouth, pungent, warm in nature.Return lung, spleen channel.Function regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.Acrid in the mouth, warm in nature.Return spleen, stomach, lung meridian.Function drying dampness to eliminate phlegm.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.

Rhizoma Pinelliae Preparatum

This product is the tuber for the aroid Rhizoma Pinelliae (Pinellia ternata (Thunb) Breit.).The dry Preparation process product that form after the soaking with Radix Glycyrrhizae lime liquor of Rhizoma Pinelliae.Acrid in the mouth, warm in nature.Return spleen, stomach, lung meridian.Function drying dampness to eliminate phlegm.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.

Poria

This product is On Polyporaceae Poria Poria cocos(Schw.) dry sclerotia of Wolf.More than excavating the 7-9 month, after digging out, remove silt, bank up after " diaphoresis ", spread out and dry in the air to dry tack free, then " diaphoresis ", after extremely now wrinkle, the large portion of internal moisture scatter and disappear for several times repeatedly, dry in the shade, be called " Poria "; Or fresh Poria is pressed to different parts cutting, cloudy in, be called " Cortex Sclerotii Poriae " and " Poria piece ".Sweet in the mouth, light, property is flat.GUIXIN, lung, spleen, kidney channel.Function promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria. phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

The Rhizoma Atractylodis Macrocephalae

This product is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..When withered and yellow, the upper leaf of bottom leaf in winter becomes fragile, excavate, remove silt, dry or dry, then remove fibrous root.Bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Function invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.

Semen Coicis

This product is the dry mature kernal of grass Semen Coicis Coix lacrymajobi L.var.mayuen. (Roman.) Stapf.Tap plant when fruit maturation autumn, dries, and lays fruit, then dry, and except decapsidate, yellowish-brown seed coat and impurity, collects kernel.Sweet in the mouth, light, cool in nature.Return spleen, stomach, lung meridian.Function promoting diuresis to eliminate damp pathogen, invigorating the spleen to arrest diarrhea, eliminating impediment, evacuation of pus, detoxicating and resolving stagnation of pathogens.For edema, beriberi, dysuria, diarrhea due to hypofunction of the spleen, arthralgia chiefly caused by damp pathogen contracture, lung abscess, acute appendicitis, wart, cancerous protuberance.

Radix Glycyrrhizae Preparata

This product is the Preparation process product of Radix Glycyrrhizae, and Radix Glycyrrhizae Preparata is the Radix Glycyrrhizae of smoking with honey.Sweet in the mouth, property is flat.GUIXIN, lung, spleen, stomach warp.Function spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.

Rhizoma Curcumae

This product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae Curcuma phaeocaulis Val., Guangxi zedoary Curcuma kwangsuensis S.G.Lee et C.F.Liang or RADIX CURCUMAE Curcuma wenyujin Y.H.Chen et C.Ling.The latter practises title " warm Rhizoma Curcumae ".Winter, stem and leaf was excavated after withered, cleaned, and steamed or boiled to the saturating heart, dry or cold drying after remove fibrous root and impurity.Acrid in the mouth, hardship, warm in nature.Return liver, spleen channel.Function circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For abdominal mass abdominal mass mass in the abdomen, blood stasis amenorrhea, obstruction of qi in the chest and cardialgia, food stagnation distending pain.

Herba Agrimoniae

This product is the dry aerial parts of rosaceous plant Agrimony Agrimonia pilosa Ledeb..Summer, autumn tap when two seasons, stem and leaf was luxuriant, remove impurity, dry.Bitter in the mouth, puckery, property is flat.GUIXIN, Liver Channel.Function astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances, tonify deficiency.For spitting of blood, spit blood, metrostaxis, malaria, dysentery, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia, de-power impairment caused by overstrain.

Radix Rubiae

This product is dry root and the rhizome of Maguireothamnus speciosus Radix Rubiae Rubia cordifolia L..Spring, Qiu Erji excavate, and remove silt, dry.Bitter in the mouth, cold in nature.Return Liver Channel.Function removing heat from blood, blood stasis dispelling, hemostasis, stimulates the menstrual flow.For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, stasis blocking amenorrhea, arthralgia, tumbling and swelling.

Endoconcha Sepiae

This product is the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune Sepiella maindronide Rochebrune or golden cuttlefish Sepia esculenta Hoyle.Collect the bone shape inner shell of sepiellae seu sepiae fish, cleaning, drying.Salty in the mouth, puckery, warm in nature.Return spleen, kidney channel.Function astringing to arrest bleeding, relieving leukorrhea by astringents, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.For hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; External treatment bleeding due to trauma, eczema eczema, ulcer being unable to heal.

Bulbus Fritillariae Thunbergii

This product is the dry bulb of liliaceous plant Bulbus Fritillariae Thunbergii FritillariathunbergiiMiq..Excavate when plant is withered early summer, cleans.Separately, large person, except coring bud, practises and claims " Bulbus Fritillariae Thunbergii " size; Little person is coring bud not, practises and claims " pearl shellfish ".Hit respectively wiping, remove crust, the conch meal of mixing to forge, sucks the juice clashing, dry; Or get bulb, and size separately, is cleaned, and except coring bud, takes advantage of fresh-cut and becomes sheet, and cleaning, drying, practise and claim " Bulbus Fritillariae Thunbergii sheet ".Bitter in the mouth, cold in nature.Return lung, heart channel.Function clearing heat, eliminating phlegm, relieving cough, detoxicating and resolving stagnation of pathogens eliminating carbuncle.For cough due to pathogenic wind-heat, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore.

Rhizoma Coptidis, Radix Scutellariae purging liver-fire in the present invention, heat clearing and damp drying, and energy anti-inflammation, the eradication rate of raising H.pylori, reduces inflammatory factor effect; Pericarpium Citri Reticulatae, Rhizoma Pinelliae Preparatum, Poria, the Rhizoma Atractylodis Macrocephalae, Semen Coicis have sending down the abnormal ascending QI dampness removing, and strengthening the spleen to promote digestion can promote gastrointestinal peristalsis, and small-molecule substance has reparation gastric mucosa, and antioxidation strengthens immunologic function; Rhizoma Curcumae, Herba Agrimoniae, Radix Rubiae energy blood circulation promoting and blood stasis dispelling, nourishing blood to restore normal menstruation, eliminating blood stasis to promote regeneration of blood, effective ingredient can activate gastrointestinal tract pacemaker cell Cajal Interstitial cell comprehensively, makes impaired cytothesis regeneration; Endoconcha Sepiae, Bulbus Fritillariae Thunbergii have effect of gastric acid inhibitory, astringing for hemostasis, containing 5-hydroxy tryptamine and another kind of material, may adsorb and have the blood of toxin and antibacterial and ooze out mucus, and contained calcium carbonate in medicine, can make antacid; Radix Glycyrrhizae Preparata energy benefiting vital QI and blood, relieving spasm to stop pain, effective ingredient can promote blood capillary regeneration, and antioxidation makes blood circulation recover self-regulating function in steady blood pressure lowering, and to Gastric cancer, tumor has fine inhibitory action.The present invention take clearing away heat-damp and promoting diuresis and stomach and alleviating pain as main, each internal organs are regulated comprehensively, differentiate deficiency and excess, accomplish that invigorating middle warmer has clearly, have in clear and fall, this is the composite treatment of comprehensive adjusting human body.

As the clinical test results of embodiment 7 and embodiment 8 shows, treatment by Chinese herbs chronic gastritis of the present invention has good effect, and effective percentage can reach more than 96%; And in the clinical process treating, have no toxic and side effects, safe and reliable.

Chinese medicine provided by the invention has overcome the defect of prior art, has outstanding substantive distinguishing features and progressive significantly with respect to prior art.

The specific embodiment

Embodiment 1

Rhizoma Coptidis 30g Radix Scutellariae 50g Pericarpium Citri Reticulatae 50g Rhizoma Pinelliae Preparatum 50g

Poria 100g Rhizoma Atractylodis Macrocephalae 100g Semen Coicis 200g Radix Glycyrrhizae Preparata 50g

Rhizoma Curcumae 100g Herba Agrimoniae 100g Radix Rubiae 20g Endoconcha Sepiae 200g

Bulbus Fritillariae Thunbergii 50g

Get whole 13 taste medical materials, extracting in water twice, adds the water of 6600g for the first time, extracts 1 hour, adds for the second time the water of 6600g, extracts 1 hour; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.20, adding ethanol to the concentration of volume percent containing alcohol amount is 50%, stir even, leave standstill 12 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.22, obtains described active component.

Embodiment 2

Rhizoma Coptidis 200g Radix Scutellariae 400g Pericarpium Citri Reticulatae 400g Rhizoma Pinelliae Preparatum 400g

Poria 500g Rhizoma Atractylodis Macrocephalae 500g Semen Coicis 600g Radix Glycyrrhizae Preparata 400g

Rhizoma Curcumae 500g Herba Agrimoniae 500g Radix Rubiae 150g Endoconcha Sepiae 600g

Bulbus Fritillariae Thunbergii 400g

Get whole 13 taste medical materials, extracting in water twice, adds the water of 71400g for the first time, extracts 3 hours, adds for the second time the water of 71400g, extracts 3 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.26, adding ethanol to the concentration of volume percent containing alcohol amount is 60%, stir even, leave standstill 24 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.30, obtains described active component.

Active component is mixed with appropriate amount of starch and dextrin, granulate, dry, tabletting, obtains tablet of the present invention.

Embodiment 3

Rhizoma Coptidis 80g Radix Scutellariae 200g Pericarpium Citri Reticulatae 200g Rhizoma Pinelliae Preparatum 240g

Poria 300g Rhizoma Atractylodis Macrocephalae 300g Semen Coicis 400g Radix Glycyrrhizae Preparata 200g

Rhizoma Curcumae 300g Herba Agrimoniae 300g Radix Rubiae 60g Endoconcha Sepiae 400g

Bulbus Fritillariae Thunbergii 200g

Get whole 13 taste medical materials, extracting in water twice, adds the water of 31800g for the first time, extracts 2 hours, adds for the second time the water of 25440g, extracts 2 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.23, adding ethanol to the concentration of volume percent containing alcohol amount is 56%, stir even, leave standstill 18 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.26, obtains described active component.

Active component is mixed with appropriate sucrose and antiseptic, add water to 3000g, obtain oral liquid of the present invention.

Embodiment 4

Rhizoma Coptidis 120g Radix Scutellariae 100g Pericarpium Citri Reticulatae 100g Rhizoma Pinelliae Preparatum 100g

Poria 200g Rhizoma Atractylodis Macrocephalae 200g Semen Coicis 300g Radix Glycyrrhizae Preparata 100g

Rhizoma Curcumae 200g Herba Agrimoniae 200g Radix Rubiae 90g Endoconcha Sepiae 300g

Bulbus Fritillariae Thunbergii 100g

Get whole 13 taste medical materials, extracting in water twice, adds the water of 16880g for the first time, extracts 1.5 hours, adds for the second time the water of 18990g, extracts 2.5 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.22, adding ethanol to the concentration of volume percent containing alcohol amount is 53%, stir even, leave standstill 16 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.28, obtains described active component.

Active component is mixed with appropriate sucrose, granulation, dry, obtain granule of the present invention.

Embodiment 5

Rhizoma Coptidis 140g Radix Scutellariae 270g Pericarpium Citri Reticulatae 300g Rhizoma Pinelliae Preparatum 280g

Poria 400g Rhizoma Atractylodis Macrocephalae 400g Semen Coicis 500g Radix Glycyrrhizae Preparata 300g

Rhizoma Curcumae 400g Herba Agrimoniae 400g Radix Rubiae 90g Endoconcha Sepiae 500g

Bulbus Fritillariae Thunbergii 300g

Get whole 13 taste medical materials, extracting in water twice, adds the water of 47080g for the first time, extracts 2.5 hours, adds for the second time the water of 29960g, extracts 1.8 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.25, adding ethanol to the concentration of volume percent containing alcohol amount is 58%, stir even, leave standstill 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.23, obtains described active component.

Active component is put in vacuum drying oven to 70 ℃ and dry, pulverize 100 mesh sieves, add appropriate amount of starch, silicon dioxide, magnesium stearate, granulation, dry, incapsulate, obtain capsule of the present invention.

Embodiment 6

Rhizoma Coptidis 50g Radix Scutellariae 90g Pericarpium Citri Reticulatae 90g Rhizoma Pinelliae Preparatum 90g

Poria 150g Rhizoma Atractylodis Macrocephalae 150g Semen Coicis 260g Radix Glycyrrhizae Preparata 240g

Rhizoma Curcumae 250g Herba Agrimoniae 250g Radix Rubiae 130g Endoconcha Sepiae 260g

Bulbus Fritillariae Thunbergii 240g

Get whole 13 taste medical materials, clean, drying and sterilizing, pulverizes, and crosses 80 orders～l20 mesh sieve, incapsulates, and to obtain final product.

Embodiment 7

The clinical trial situation of Chinese medicine of the present invention:

1, case selection, patient age scope, course of disease time

Choose Patients with Chronic Gastritis 120 examples, be divided at random 2 groups.Treatment group 60 examples, male 35 examples, female's 25 examples; Age 18-70 year, average 46.5 years old; The course of disease 10 weeks-2 years, average 1.65.Matched group 60 examples, male 34 examples, female's 26 examples; Age 19-69 year, average 45.8 years old; The course of disease 10 weeks-2.5 years, average 1.71.

2, diagnostic criteria brief introduction

(tentative program) is dialectical is spleen and stomach damp-heat type in " the chronic gastritis combination of Chinese and Western medicine diagnosis, dialectical and criterion of therapeutical effect " of formulating with reference to Chinese Association of the Integration of Traditional Chinese Medicine and Western Medicine digestive system disease Professional Committee.Clinical manifestation: epigastrium or gastral cavilty feeling of fullness are scorching hot, distending pain, belch, or pantothenic acid, bitter taste, halitosis, red tongue, yellow fur is thick or greasy.Gastroscopy: see the obvious edema of gastric mucosa, hyperemia, erosion under scope.

3, curative effect determinate standard:

With reference to " chronic gastritis combination of Chinese and Western medicine diagnosis, dialectical and criterion of therapeutical effect " (tentative program), clinical recovery: clinical cardinal symptom all disappears, gastroscope check Active inflammation disappears, and chronic inflammatory disease is pass on well slightly.Effective: clinical cardinal symptom disappears, and inferior disease disappears substantially, gastroscope check Active inflammation disappears substantially, and chronic inflammatory disease takes a turn for the better.Effective: cardinal symptom obviously alleviates.Gastroscope check mucosa extent of disease dwindles more than 1/2, and inflammation alleviates to some extent.Invalid: symptom is without change, and gastroscopy does not reach effective standard, also without deterioration person.

4, drug use method

Treatment group: take the medicine of the embodiment of the present invention 3, every day twice, ante cibum 30, min was oral, each serving the medicine with being equivalent to crude drug amount 20g.

Matched group: omeprazole enteric-coated capsules (Kunshan dragon lantern Rui Di pharmaceutical Co. Ltd, the accurate word H20033373 of traditional Chinese medicines) 20 mg, every day 2 times, ante cibum 30, min was oral.

5, clinical treatment result, gathers with form

5.1 liang of group Clinical efficacy comparisons are in table 1.

2 groups of Clinical efficacy comparisons of table l

Group	n	Clinical recovery	Effective	Effectively	Invalid	Total effective rate %
							Treatment group	60	32	21	5	2	96.7*
Matched group	60	21	14	16	9	85

With matched group comparison, * P<0.05

From table 1, two groups always have effective percentage comparing difference to have statistical significance (P<0.05), and treatment group curative effect is better than matched group.

Before and after 5.2 liang of group treatments, symptom integral is relatively in table 2.

Symptom integral comparison before and after table 2 liang group treatment

With this group before treatment, * P<0.05; With comparison after treatment of control group, #P<0.05

From table 2, after 2 groups of treatments, each symptom integral all obviously reduces, and all has statistical significance (P<0.05) with comparing difference before treatment; Treatment after 2 groups except epigastric upset, bitter taste xerostomia, all the other symptom integral comparing differences all have statistical significance (P<0.05), treatment group is lower than matched group.

Organize two groups of relapse rate comparisons for 5.3 liang and all follow up a case by regular visits to 12 weeks, treatment group 60 examples, cure 32 examples, and recurrence 3 examples, account for 9.4%; Matched group 60 examples, cure 2l example, and recurrence 7 examples, account for 33.3%.2 groups of relapse rate comparing differences have statistical significance (P<0.05), and treatment group is lower than matched group.

, there are constipation 2 examples in 5.4 untoward reaction treatment group 60 examples, diarrhoea 2 examples, and taupe is 1 example just; , there are insomnia 3 examples in matched group 60 examples, stomachache 4 examples, and pitchy is 1 example just.After finish 2 courses for the treatment of, in 2 weeks, two groups of untoward reaction all disappear.

Embodiment 8

1, Wei ×, man, 56 years old, people from Liucheng County, Guangxi, case history 6 years, the scorching hot dull pain of symptom gastral cavilty portion 6 years, bitter taste, dry pharynx, constipation with dry stool is difficult to resolve, 3-5 days 1 row, red tongue, yellow and greasy fur, the People's Hospital's outpatient service is interrupted medical, and gastroscopy is shown: chronic erosive gastritis.Oral " rabeprazole enteric coated capsule " 20mg, bid, bad when symptom fashion; Treat through medicine of the present invention, treat symptom after 14 days and obviously alleviate, follow up a case by regular visits to and have no recurrence half a year.”

2, Huang ×, female, 26 years old, people from Guilin, case history 1 year, symptom gastral cavilty feeling of fullness distending pain, belch, halitosis, red tongue, yellow fur is thick.Local hospital outpatient service is interrupted medical, and gastroscopy is shown: chronic superficial gastritis.Oral " domperidone tablet " 10 mg, every day 3 times, bad when symptom fashion; Treat through medicine of the present invention, treat symptom after 7 days and obviously alleviate, follow up a case by regular visits to and within 1 year, have no recurrence.”

3, " high ×, man, 38 years old, Guangxi San Jiangxian people, case history 10 years, the scorching hot distending pain of symptom gastral cavilty portion 10 years, bitter taste, dry pharynx, constipation with dry stool is difficult to resolve, 2 days 1 row, red tongue, yellow and greasy fur, local hospital is interrupted medical (concrete medication is not quite clear), and symptom has no alleviation; Treat through medicine of the present invention, treat symptom after 18 days and obviously alleviate, follow up a case by regular visits to and have no recurrence half a year.”

4, old ×, man, 56 years old, people from Liuzhou, case history 3 years, the scorching hot dull pain of symptom gastral cavilty portion 3 years, bitter taste, dry pharynx, constipation with dry stool is difficult to resolve, 1 day 1 row, red tongue, yellow fur is thick, workers' hospital's outpatient service is interrupted medical, gastroscopy is shown: chronic erosive gastritis.Oral " rabeprazole enteric coated capsule " 10mg, bid, bad when symptom fashion; Treat through medicine of the present invention, treat symptom after 14 days and obviously alleviate, follow up a case by regular visits to and have no recurrence half a year.”

5, " Liu ×, female, 65 years old, people from Liujiang County, Guangxi, case history July, the scorching hot dull pain of symptom gastral cavilty portion 2 years, bitter taste, belch, dry pharynx, stool is still adjusted, red tongue, yellow fur, Liujiang hospital outpatient is interrupted medical, and gastroscopy is shown: chronic erosive gastritis.Oral " rabeprazole enteric coated capsule " 20mg, bid, " amoxicillin 0.5g, every day 2 times, bad when symptom fashion; Treat through medicine of the present invention, treat symptom after 15 days and obviously alleviate, follow up a case by regular visits to and have no recurrence half a year.”

Claims (7)

1. treat a Chinese medicine for chronic gastritis, it is characterized in that it is to be prepared from by the raw material of following weight portion:

2. the Chinese medicine for the treatment of chronic gastritis as claimed in claim 1, is characterized in that it is to be prepared from by the raw material of following weight portion:

3. the Chinese medicine for the treatment of chronic gastritis as claimed in claim 2, is characterized in that it is to be prepared from by the raw material of following weight portion:

4. the Chinese medicine for the treatment of chronic gastritis as claimed in claim 1, is characterized in that its active component is prepared from by the following method:

Get whole 13 taste medical materials, extracting in water twice, adds the water that is equivalent to 6～12 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 6～12 times of medical material gross weights, extracts 1～3 hour; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.20～1.26, adding ethanol to the concentration of volume percent containing alcohol amount is 50%～60%, stir even, leave standstill 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.22～1.30, obtains described active component.

5. the Chinese medicine for the treatment of chronic gastritis as claimed in claim 1, is characterized in that its active component is prepared from by the following method:

Get whole 13 taste medical materials, extracting in water twice, adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 8～10 times of medical material gross weights, extracts 2 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.23, adding ethanol to the concentration of volume percent containing alcohol amount is 56%, stir even, leave standstill 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.26, obtains described active component.

6. the Chinese medicine for the treatment of chronic gastritis as claimed in claim 1, is characterized in that its capsule is prepared from by the following method:

Get whole 13 taste medical materials, clean, drying and sterilizing, pulverizes, and crosses 80 orders～l20 mesh sieve, incapsulates, and to obtain final product.

7. treat a Chinese medicine preparation for chronic gastritis, comprise the Chinese medicine for the treatment of chronic gastritis of any one in claim 1～5 and pharmaceutically acceptable carrier.