CN1679740A - Production of gastric ulcer capsule - Google Patents
Production of gastric ulcer capsule Download PDFInfo
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- CN1679740A CN1679740A CN 200510012322 CN200510012322A CN1679740A CN 1679740 A CN1679740 A CN 1679740A CN 200510012322 CN200510012322 CN 200510012322 CN 200510012322 A CN200510012322 A CN 200510012322A CN 1679740 A CN1679740 A CN 1679740A
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- rhizoma zingiberis
- zingiberis recens
- radix
- volatile oil
- gastric ulcer
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Abstract
A Chinese medicine in the form of capsule for treating gastritive ulcer is prepared from 6 Chinese-medicinal materials including ginger, astragalus root, cinnamon twigs, white peony root, etc through extracting volatile oil from ginger, mixing its dregs with others, decocting twice, collecting decoction, filtering, vacuum concentrating, drying, spraying said volatile oil, pulverizing and loading in capsules.
Description
One, technical field
The invention belongs to a kind of treatment chronic gastritis, the manufacture method of the pure Chinese medicinal preparation of duodenal ulcer is specifically related to a kind of manufacture method of gastric ulcer capsule.
Two, background technology
There is very abundant pools of traditional Chinese medicine in China, but awaits to discover and use.The a lot of original very effective Chinese medicinal formulaes of China, because of being subjected to the influence of factors such as technology of preparing, preparation technology and dosage form packing, greatly overslaugh in the sale of international market, improve the research of raising pharmacy new technique novel form for this reason, also be imminent.With regard to stomach infections granule, bigger again on dose, bitter again peppery on mouthfeel, take very inconvenience.Become the patient who suffers from diabetes simultaneously and avoid and take medicine, its range of application is restricted.For example the patent No. is that 00108027 Chinese medicine also exists foreign odor, and the drug volatilization effect is fast, and drug effect is not lasting, shortcomings such as amount matter instability.
Three, summary of the invention
The present invention will solve existing manufacturing process and dosage form is taken extremely inconvenience, hinders the characteristic Chinese medicine and moves towards domestic market and international market, makes diabetics because medicine contains the problem that sugar can not be taken.
The technical scheme that the present invention realizes: a kind of manufacture method of gastric ulcer capsule, it is to be made by the following weight proportion raw material: Radix Astragali 210-330 part, Radix Glycyrrhizae 160-268 part, Radix Paeoniae Alba 118-192 part, Fructus Jujubae 69-135 part, Ramulus Cinnamomi 72-118 part, Rhizoma Zingiberis Recens 69-116 part is extracted volatile oil with Rhizoma Zingiberis Recens, the medicinal residues and the Radix Astragali, Ramulus Cinnamomi, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Jujubae, decoct with water twice, 2.5 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, it is 1.30 clear paste that filtrate decompression is concentrated into relative density, freeze-day with constant temperature (45～55 ℃), spray into Rhizoma Zingiberis Recens volatile oil, pulverize, mixing, in incapsulating promptly.This method can also manufacture stomach infections soft capsule, microcapsule, tablet, concentrated pill, drop pill.
The present invention compares with prior art has following beneficial effect: prescription is unique, and preparation method is simple, and medicinal raw material is abundant, and cost is low, treats easy to usely, and determined curative effect is reliable, has no side effect, and is easy to apply.Reduced auxiliary materials sugar and dextrin, diabetics also can be taken.The medicine that refines is made dosage forms such as capsule or soft capsule, microcapsule, tablet, drop pill, be convenient to the use of popularity, reduced the bitter peppery of mouthfeel when taking medicine, not only brought superiority, and also brought the advantage of market sale to pharmacy corporation to the patient.In Shanxi Jin Kang hospital, use gastric ulcer capsule treatment superficial gastritis 26 routine observation of curative effect: shallow property gastritis is clinical common digestive system disease.From in March, 2002-2003 year December, using Drug therapy that the gastric ulcer capsule manufacture method makes should disease, obtains curative effect preferably, now is summarized as follows.
Clinical data
Observe case 26 examples, all with reference to " dialectical and criterion of therapeutical effect is diagnosed in the chronic gastritis combination of Chinese and Western medicine ", clinical manifestation has epigastric burning pain or feeling of distension and oppression, nausea and vomiting, belch bitter taste, noisy, the indigestion and loss of appetite symptom for the treatment of.The visible gastric mucosa hyperemia of gastroscope, edema, point-like erosion etc.And eliminating occupying lesion.Wherein male 14 examples, women 12 examples; Age 20-60 year; Course of disease June-10 year.
Therapeutic Method
Gastric ulcer capsule, oral, every day 3 times, each 3,15 days is that a journey is treated.
Observation index is clinical efficacy 1.; 2. cardinal symptom integration before and after the treatment: according to paresthesia epilepsy degree such as upper abdominal pain, feeling of fullness, scorching hot heartburn, belch and persistent period respectively 0,1,2,3 four grade score, write down weekly 1 time.3. check finding under the gastroscope before the treatment and in 1 week of drug withdrawal, every indexs such as gastric mucosa edema, hyperemia, erosion, hemorrhage speckle are scored by being divided into 0,1,2,3 four grade in various degree.4. badly do not react: all check indexs such as routine blood test, routine urinalysis, liver function, renal function, blood glucose and blood fat before and after the treatment.
Statistical procedures adopts t check X
2Check.
Criterion of therapeutical effect and therapeutic outcome
With reference to " the dialectical and criterion of therapeutical effect of chronic gastritis combination of Chinese and Western medicine diagnosis ".Cure: clinical symptoms all disappears, and gastroscopy is normal substantially, and gastric mucus is more clear, and symptom integral and gastroscope integration are 0 minute.Produce effects: clinical cardinal symptom major part disappears or is clearly better, and gastroscopy mucous hyperemia edema obviously alleviates, and treatment back symptom integral and gastroscope integration reduce more than 2/3 than before treating.Effectively: clinical cardinal symptom partly disappears or takes a turn for the better, and gastroscopy gastric mucosa congestion and edema alleviates, and treatment back symptom integral and gastroscope integration reduce more than 1/3 than treatment is preceding.Invalid: treatment front and back cardinal symptom and gastric mucosa are checked no change or are increased the weight of.
The cardinal symptom integration relatively before and after table 1 treatment
| Symptom | Before the treatment | After the treatment |
| The scorching hot heartburn belch of upper abdominal pain feeling of fullness | ????2.8±0.5 ????2.1±0.9 ????1.5±0.7 ????1.3±0.5 | ????0.3±0.5 ????0.2±0.3 ????0.1±0.3 ????0.1±0.2 |
Compare P＜0.05 before and after the treatment
The every index integration variation of gastroscopy relatively sees Table 2 before and after the group treatment
The every index integration of gastroscope changes relatively before and after table 2 treatment
| Project | Before the treatment | After the treatment |
| The congested gastric mucosa edema of gastric mucosa gastric mucosal erosion | ????2.3±0.5 ????2.2±0.6 ????1.8±0.9 | ????0.5±0.2 ????0.5±0.1 ????0.3±0.1 |
| The gastric bleeding speckle | ????1.2±0.3 | ????0.3±0.2 |
Compare P＜0.05 before and after the treatment
Brief summary
The clinically Drug therapys of using stomach motility enhancing medicine, gastric mucosa protectant of superficial gastritis more.The primary disease disease can belong to categories such as Chinese medicine gastric abscess, vomiting, stomach painful abdominal mass.Its morbidity is many because of feelings will internal injury, irritability stasis, incoordination between the liver and stomach, perverse and unreasonable manner criminal stomach; Or eating and drinking without temperance, impairing the spleen and stomach, damp and hot in resistance, cause stomach-QI being unable to descend normally, adverse rising of stomach-QI, thereby cause all diseases such as epigastrium pain, feeling of fullness, noisy heartburn, bitter taste vomiting, belch.Primary disease simulataneous insufficiency and excessive, insufficiency of the spleen stagnation of liver-QI abnormal ascending-descending of QI is it, the pertinacious phlegm blood-stasis internal-depression is its mark, thus should note in the treatment in dredging profit, suing for peace, among residence is negligent of mending.During Radix Astragali invigorating the spleen and benefiting QI was carried, Ramulus Cinnamomi, Rhizoma Zingiberis Recens warming middle-JIAO and cold expelling heresy be pain, and Fructus Jujubae and taste can straight angry blood.All medicines share, and Cause ﹠ Symptom Solution reaches the liver stomach and rules together, and tonifying the spleen is contained the merit of wood.
Four, the specific embodiment
Embodiment 1
A kind of manufacture method of gastric ulcer capsule, it is to be made by the following weight proportion raw material: the Radix Astragali 250 grams, Radix Glycyrrhizae 200 grams, the Radix Paeoniae Alba 150 grams, Fructus Jujubae 100 grams, Ramulus Cinnamomi 80 grams, Rhizoma Zingiberis Recens 80 grams extract volatile oil with Rhizoma Zingiberis Recens, the medicinal residues and the Radix Astragali, Ramulus Cinnamomi, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Jujubae decocts with water twice, 2.5 hours for the first time, 1.5 hours for the second time, collecting decoction filters, and it is 1.30 clear paste that filtrate decompression is concentrated into relative density, freeze-day with constant temperature (55 ℃), spray into Rhizoma Zingiberis Recens volatile oil, pulverize mixing, promptly, specification is every 0.5 gram in 200 capsules of packing into.Usage: oral one time six, three times on the one.
Embodiment 2: a kind of manufacture method of gastric ulcer capsule, and it is to be made by the following weight proportion raw material: the Radix Astragali 210 grams, Radix Glycyrrhizae 160 grams, the Radix Paeoniae Alba 118 grams, Fructus Jujubae 69 grams, Ramulus Cinnamomi 72 grams, Rhizoma Zingiberis Recens 69 grams extract volatile oil with Rhizoma Zingiberis Recens, the medicinal residues and the Radix Astragali, Ramulus Cinnamomi, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Jujubae decocts with water twice, 2.5 hours for the first time, 1.5 hours for the second time, collecting decoction filters, and it is 1.30 clear paste that filtrate decompression is concentrated into relative density, freeze-day with constant temperature (45 ℃), spray into Rhizoma Zingiberis Recens volatile oil, pulverize mixing, promptly, specification is every 0.5 gram in 162 capsules of packing into.Usage: oral one time six, three times on the one.
The manufacture method of 3 one kinds of gastric ulcer capsules of embodiment, it is to be made by the following weight proportion raw material: the Radix Astragali 330 grams, Radix Glycyrrhizae 268 grams, the Radix Paeoniae Alba 192 grams, Fructus Jujubae 135 grams, Ramulus Cinnamomi 118 grams, Rhizoma Zingiberis Recens 116 grams extract volatile oil with Rhizoma Zingiberis Recens, the medicinal residues and the Radix Astragali, Ramulus Cinnamomi, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Jujubae decocts with water twice, 2.5 hours for the first time, 1.5 hours for the second time, collecting decoction filters, and it is 1.30 clear paste that filtrate decompression is concentrated into relative density, freeze-day with constant temperature (49 ℃), spray into Rhizoma Zingiberis Recens volatile oil, pulverize mixing, promptly, specification is every 0.5 gram in 271 capsules of packing into.Usage: oral one time six, three times on the one.
Claims (2)
1, the manufacture method of gastric ulcer capsule is characterized in that: it is to be made by the following weight proportion raw material: Radix Astragali 210-330 part, Radix Glycyrrhizae 160-268 part, Radix Paeoniae Alba 118-192 part, Fructus Jujubae 69-135 part, Ramulus Cinnamomi 72-118 part, Rhizoma Zingiberis Recens 69-116 part is extracted volatile oil with Rhizoma Zingiberis Recens, the medicinal residues and the Radix Astragali, Ramulus Cinnamomi, the Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Jujubae, decoct with water twice, 2.5 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, it is 1.30 clear paste that filtrate decompression is concentrated into relative density, freeze-day with constant temperature (45～55 ℃), spray into Rhizoma Zingiberis Recens volatile oil, pulverize, mixing, in incapsulating promptly.
2, the manufacture method of a kind of gastric ulcer capsule according to claim 1 is characterized in that: this method can also manufacture stomach infections soft capsule, microcapsule, tablet, concentrated pill, drop pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510012322 CN1679740A (en) | 2005-01-14 | 2005-01-14 | Production of gastric ulcer capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510012322 CN1679740A (en) | 2005-01-14 | 2005-01-14 | Production of gastric ulcer capsule |
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| CN1679740A true CN1679740A (en) | 2005-10-12 |
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| CN 200510012322 Pending CN1679740A (en) | 2005-01-14 | 2005-01-14 | Production of gastric ulcer capsule |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000312A (en) * | 2010-11-15 | 2011-04-06 | 姜家勇 | Traditional Chinese medicinal formula for treating enteritis and gastropathy |
| CN102973906A (en) * | 2011-09-02 | 2013-03-20 | 湖南富兴飞鸽药业有限公司 | Weiyangling and preparation method thereof |
| CN105396092A (en) * | 2015-11-26 | 2016-03-16 | 王雅芳 | Traditional Chinese medicine formula for treating spleen deficiency and stomach cold |
| CN109481662A (en) * | 2018-12-28 | 2019-03-19 | 商洛市中医医院 | Two winter of rhizoma polygonati Stomach Nourishing Decoction |
-
2005
- 2005-01-14 CN CN 200510012322 patent/CN1679740A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000312A (en) * | 2010-11-15 | 2011-04-06 | 姜家勇 | Traditional Chinese medicinal formula for treating enteritis and gastropathy |
| CN102973906A (en) * | 2011-09-02 | 2013-03-20 | 湖南富兴飞鸽药业有限公司 | Weiyangling and preparation method thereof |
| CN105396092A (en) * | 2015-11-26 | 2016-03-16 | 王雅芳 | Traditional Chinese medicine formula for treating spleen deficiency and stomach cold |
| CN109481662A (en) * | 2018-12-28 | 2019-03-19 | 商洛市中医医院 | Two winter of rhizoma polygonati Stomach Nourishing Decoction |
| CN109481662B (en) * | 2018-12-28 | 2021-10-19 | 商洛市中医医院 | Stomach-nourishing soup containing rhizoma polygonati, radix ophiopogonis and radix ophiopogonis |
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