CN101129830B

CN101129830B - Medicine for treating urinary system affection and method of preparing the same

Info

Publication number: CN101129830B
Application number: CN2007101137995A
Authority: CN
Inventors: 赵翠玲
Original assignee: Individual
Current assignee: Individual
Priority date: 2007-09-12
Filing date: 2007-09-12
Publication date: 2010-06-02
Anticipated expiration: 2027-09-12
Also published as: CN101129830A

Abstract

The invention relates to a pharmaceutical composition for treating urinary system infection and process for preparation, wherein the raw materials include (by mass ratio) honey-suckle stem 12-17%, cogongrass rhizome 12-17%, motherwort herb 8-12%, bamboo leaves 5-7%, garden burnet root charcoal 8-12%, giant knotweed rhizome 12-17%, dried rehmannia root 8-12%, pinellia tuber 5-7%, poria cocos wolf 8-12% and licorice root 5-7%.

Description

Medicine of treatment urinary system infection and preparation method thereof

Technical field:

The present invention relates to a kind of medicine for the treatment of urinary system infection and preparation method thereof, medicine is used for the treatment of infection diseases of urinary system such as acute pyelonephritis, cystitis, urethritis.

Background technology:

Treatment urinary system infection Western medicine commonly used, but untoward reaction is in use arranged easily.For example: penicillin: allergy and delayed reaction are often arranged, and a lot of patients can not use; Erythromycin: after the oral or injection, all can cause the side effect of symptom of digestive tract, symptoms such as that patient often has is nauseating, vomiting, enterospasm; Lincomycin: occur the situation of pathogenic people's death in recent years, it is inactive now to have stopped production; Norfloxacin (PPA): hinder the absorption of calcium, phosphorus the back of taking medicine; Hydrochlorothiazide: a diuresis, do not effect a permanent cure, do not reach the purpose for the treatment of both the principal and secondary aspects of a disease.

Summary of the invention:

The purpose of this invention is to provide a kind of medicine for the treatment of urinary system infection and preparation method thereof, can prepare the medicine of treatment urinary system infection, this medication effect is good, and patient does not in use have untoward reaction.

The objective of the invention is to realize as follows: the medicine of this treatment urinary system infection, its material medicine by the component of quality is: Caulis Lonicerae 12-17%, Rhizoma Imperatae 12-17%, Herba Leonuri 8-12%, Folium Bambusae 5-7%, charred Radix Sanguisorbae 8-12%, Rhizoma Polygoni Cuspidati 12-17%, Radix Rehmanniae 8-12%, Rhizoma Pinelliae 5-7%, Poria 8-12%, Radix Glycyrrhizae 5-7%.According to above drug component, by existing manufacturing technique, can be made into medicament forms such as powder, tablet, pill, oral liquid, different dosage forms need be dosed different auxiliary elements certainly.

A kind of preparation method of oral liquid of as above medicine is: get material medicine in proportion, charred Radix Sanguisorbae is placed in the homogenizer, the amount that is 60%-80% aqueous acetone 2ml by corresponding 1 gram charred Radix Sanguisorbae adding Capacity Ratio at room temperature is broken into homogenate, get rid of filter, add acetone extraction repeatedly 3 times, extracting solution is filtered, and device is preserved in addition; Get Poria, amount by the corresponding 5ml of 1 gram Poria is mixed thoroughly under 0-3 ℃ of temperature with the NaOH solution of 0.5mol/L, place after 3 hours, high speed centrifugation, the clear liquor adding Capacity Ratio that obtains is 10% acetic acid neutralization, separates out precipitation, successively water, acetone, ether washing precipitation, get pachyman after the drying, place; All the other 8 flavor material medicines decoct with water twice, add the 1.1-1.3ml decocting by 1 gram material medicine for the first time and boil 1.5 hours, add the 0.9-1.1ml decocting by 1 gram material medicine for the second time and boil 1 hour, merge decoction liquor, filter, filtrate adds ethanol makes its precipitation, gets the supernatant decompression recycling ethanol, leave standstill, get supernatant and filter, the filtrate that obtains is added charred Radix Sanguisorbae extracting solution and pachyman, mixing, the mixed liquor that 10 kinds of material medicines of corresponding 1 gram obtain concentrates or is adjusted to 0.8-1.2ml, obtains oral liquid.Can be distributed into bottle then, sterilization, packing become the listing product.

Consumption: every day twice, about each 100ml.

The side separates: Caulis Lonicerae (Caulis Lonicerae): clearing away heat and expelling wind, the poison that is situated between, logical blood are active; Rhizoma Imperatae: heat clearing away, diuresis, expel the heat-evil long-pending; Herba Leonuri: the water that is used to disappear, detoxifcation, diuretic, the blood blood stasis dispelling of subsiding a swelling, disappear; Folium Bambusae: heat clearing away, diuresis, relieving restlessness; Charred Radix Sanguisorbae: heat clearing away, hemostasis; Rhizoma Polygoni Cuspidati: rush down wet, diuresis, difficulty and pain in micturition, hematuria dysurea etc. due to the stranguria damp-heat accumulation bladder are had therapeutical effect; The Radix Rehmanniae: heat clearing away, pathogenic fire purging, grow the liquid rescuing YIN, replenishing YIN and removing heat, the cough-relieving of promoting the production of body fluid; The Rhizoma Pinelliae: be used for stopping nausea and vomiting by lowering the adverse flow of QI, clear painful abdominal mass eliminating stagnation; Poria: diuretic, eliminating dampness by diuresis, invigorating middle warmer, calm the nerves; Radix Glycyrrhizae: QI invigorating, invigorating middle warmer, heat clearing away are situated between malicious, relieving spasm to stop pain, the mediation property of medicine.More than the full side of 10 flavor Chinese medicines the link closely cause of disease, the pathogenesis of urinary system, blood circulation promoting and blood stasis dispelling, detumescence, diuretic, heat clearing away, hemostasis, treatment urgent micturition, dysurea.

Take medicine back 1-2 days of patient, urgent micturition, dysurea are alleviated, 1 week back hematuria naked eyes change clear, 2 week the back clinical symptoms and biochemical chamber detect normal.This medicine is used for the treatment of urinary system infection 300 examples, cures 260 examples, 30 examples that take a turn for the better, and effective percentage is 97%.

This medicine is used for the treatment of urinary system infection, has no side effect, and avirulence is made the drink form taking convenience, and treatment can be received the effect of getting instant result.Preparation method is operated easily, and equipment investment is few.

The specific embodiment:

Embodiment 1

It is standby to get Caulis Lonicerae 150 gram, Rhizoma Imperatae 150 grams, Herba Leonuri 100 grams, Folium Bambusae 60 grams, charred Radix Sanguisorbae 100 grams, Rhizoma Polygoni Cuspidati 150 grams, the Radix Rehmanniae 100 grams, the Rhizoma Pinelliae 60 grams, Poria 100 grams, Radix Glycyrrhizae 60 grams.Charred Radix Sanguisorbae is placed in the homogenizer, and adding Capacity Ratio is the aqueous acetone 200ml of 60%-80%, at room temperature is broken into homogenate, gets rid of filter, adds acetone 200ml at every turn and extracts altogether 3 times, and extracting solution is filtered, and device is preserved in addition; Get Poria, under 0-3 ℃ of temperature, mix thoroughly, place after 3 hours with the NaOH solution 500ml of 0.5mol/L, high speed centrifugation, the clear liquor that obtains adding Capacity Ratio are 10% acetic acid neutralization, separate out precipitation, water, acetone, ether washing precipitation successively gets pachyman after the drying, place; All the other 8 flavor material medicines decoct with water twice, and the decocting that adds 1000ml for the first time boiled 1.5 hours, and the decocting that adds 800ml for the second time boiled 1 hour, merge decoction liquor, filter, filtrate adds ethanol makes its precipitation, get the supernatant decompression recycling ethanol, leave standstill, get supernatant and filter, the filtrate that obtains is added charred Radix Sanguisorbae extracting solution and pachyman, and mixing is concentrated into 1000ml, obtain oral liquid, be filled in the bottle every bottle of 100ml, sterilization.

Embodiment 2

It is standby to get Caulis Lonicerae 3000 gram, Rhizoma Imperatae 3000 grams, Herba Leonuri 2000 grams, Folium Bambusae 1100 grams, charred Radix Sanguisorbae 2000 grams, Rhizoma Polygoni Cuspidati 3000 grams, the Radix Rehmanniae 2000 grams, the Rhizoma Pinelliae 1200 grams, Poria 2000 grams, Radix Glycyrrhizae 1300 grams.Charred Radix Sanguisorbae is placed in the homogenizer, and adding Capacity Ratio is the aqueous acetone 4000ml of 60%-80%, at room temperature is broken into homogenate, gets rid of filter, adds acetone 4000ml at every turn and extracts altogether 3 times, and extracting solution is filtered, and device is preserved in addition; Get Poria, under 0-3 ℃ of temperature, mix thoroughly, place after 3 hours with the NaOH solution 10000ml of 0.5mol/L, high speed centrifugation, the clear liquor that obtains adding Capacity Ratio are 10% acetic acid neutralization, separate out precipitation, water, acetone, ether washing precipitation successively gets pachyman after the drying, place; All the other 8 flavor material medicines decoct with water twice, and the decocting that adds 20000ml for the first time boiled 1.5 hours, and the decocting that adds 16000ml for the second time boiled 1 hour, merge decoction liquor, filter, filtrate adds ethanol makes its precipitation, get the supernatant decompression recycling ethanol, leave standstill, get supernatant and filter, the filtrate that obtains is added charred Radix Sanguisorbae extracting solution and pachyman, and mixing is concentrated into 20000ml, obtain oral liquid, be filled in the bottle every bottle of 100ml, sterilization.For adjusting mouthfeel, also can add an amount of sucrose.

Embodiment 3

It is standby to get Caulis Lonicerae 1500 gram, Rhizoma Imperatae 1400 grams, Herba Leonuri 900 grams, Folium Bambusae 600 grams, charred Radix Sanguisorbae 1000 grams, Rhizoma Polygoni Cuspidati 1600 grams, the Radix Rehmanniae 1100 grams, the Rhizoma Pinelliae 600 grams, Poria 1000 grams, Radix Glycyrrhizae 600 grams.Charred Radix Sanguisorbae is placed in the homogenizer, and adding Capacity Ratio is the aqueous acetone 2000ml of 60%-80%, at room temperature is broken into homogenate, gets rid of filter, adds acetone 2000ml at every turn and extracts altogether 3 times, and extracting solution is filtered, and device is preserved in addition; Get Poria, under 0-3 ℃ of temperature, mix thoroughly, place after 3 hours with the NaOH solution 5000ml of 0.5mol/L, high speed centrifugation, the clear liquor that obtains adding Capacity Ratio are 10% acetic acid neutralization, separate out precipitation, water, acetone, ether washing precipitation successively gets pachyman after the drying, place; All the other 8 flavor material medicines decoct with water twice, and the decocting that adds 10000ml for the first time boiled 1.5 hours, and the decocting that adds 8000ml for the second time boiled 1 hour, merge decoction liquor, filter, filtrate adds ethanol makes its precipitation, get the supernatant decompression recycling ethanol, leave standstill, get supernatant and filter, the filtrate that obtains is added charred Radix Sanguisorbae extracting solution and pachyman, and mixing is concentrated into 10000ml, obtain oral liquid, be filled in the bottle every bottle of 100ml, sterilization.

Claims

1. a medicine for the treatment of urinary system infection is characterized in that material medicine by the component of quality is: Caulis Lonicerae 12-17%, Rhizoma Imperatae 12-17%, Herba Leonuri 8-12%, Folium Bambusae 5-7%, charred Radix Sanguisorbae 8-12%, Rhizoma Polygoni Cuspidati 12-17%, Radix Rehmanniae 8-12%, Rhizoma Pinelliae 5-7%, Poria 8-12%, Radix Glycyrrhizae 5-7%.

2. the preparation method of the oral liquid of a medicine as claimed in claim 1, it is characterized in that: get material medicine in proportion, charred Radix Sanguisorbae is placed in the homogenizer, the amount that is 60%-80% aqueous acetone 2ml by corresponding 1 gram charred Radix Sanguisorbae adding Capacity Ratio at room temperature is broken into homogenate, get rid of filter, add acetone extraction repeatedly 3 times, extracting solution is filtered, device is preserved in addition; Get Poria, amount by the corresponding 5ml of 1 gram Poria is mixed thoroughly under 0-3 ℃ of temperature with the NaOH solution of 0.5mol/L, place after 3 hours, high speed centrifugation, the clear liquor adding Capacity Ratio that obtains is 10% acetic acid neutralization, separates out precipitation, successively water, acetone, ether washing precipitation, get pachyman after the drying, place; All the other 8 flavor material medicines decoct with water twice, adding the 1.1-1.3ml decocting by 1 gram material medicine for the first time boiled 1.5 hours, adding the 0.9-1.1ml decocting by 1 gram material medicine for the second time boiled 1 hour, merge decoction liquor, filter, filtrate adds ethanol makes its precipitation, get the supernatant decompression recycling ethanol, leave standstill, get supernatant and filter, the filtrate that obtains is added charred Radix Sanguisorbae extracting solution and pachyman, mixing, the mixed liquor that 10 kinds of material medicines of corresponding 1 gram obtain concentrates or is adjusted to 0.8-1.2ml, the oral liquid of the urinary system infection that obtains medical treatment.