CN109330958B - Application of traditional Chinese medicine composition in preparation of bath agent - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9741—Pteridophyta [ferns]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The invention discloses an application of a traditional Chinese medicine composition in preparing a bath agent, relating to the technical field of oral care, namely, in the process of preparing the bath agent, a compound traditional Chinese medicine extract is added into the bath agent as the only active component with the functions of diminishing inflammation and relieving itching, the compound traditional Chinese medicine extract is a clinopodium polycephalum extract, a perilla leaf extract, a patrinia scabiosaefolia bunge extract, a sweet wormwood herb extract, a glabrous sarcandra herb extract, a suberect spatholobus stem extract, a phellodendron bark extract, a herba siegesbeckiae extract, a lycopodium clavatum extract, a cinnamon extract and a ginger extract, the mass ratio of the extracts is 1:2:2:1: 2, the traditional Chinese medicine composition is safe to use, has the functions of diminishing inflammation and relieving itching, clearing heat, cooling blood and removing bacteria, can remove miliaria and resist allergy, simultaneously reduces the irritation of the product, and is, has regulating and protecting effects on skin, can be used daily, and is simple to prepare.
Description
Technical Field
The invention relates to the technical field of washing and caring products, in particular to a bathing agent with effects of clearing heat, cooling blood and removing bacteria.
Background
With the continuous improvement of living standard, people pay more and more attention to self sanitary bathing conditions, the bathing agent becomes a necessity of every family, and when people take a bath, a plurality of bathing agent products are properly used, grease and scurf on the skin can be effectively removed, so that people feel fresh and comfortable. In the past, the hair washing and bathing products are mostly prepared from chemical raw materials in the market at present, wherein the raw materials comprise cationic polymers, silicone oil, fatty alcohol polyoxyethylene ether sulfate, alkanolamide, betaine and amine oxide, most of the chemical raw materials synthesized by the chemical industry have stimulation on skin and hair, and are harmful to the health of the skin after long-term use; later, through research and improvement, various Chinese herbal medicines are added into the bathing agent to achieve the purposes of diminishing inflammation and relieving itching; however, the Chinese herbal medicines of a plurality of bath agents are unreasonably matched or improperly selected, and the anti-inflammatory and antipruritic effects are not obvious.
Disclosure of Invention
The invention aims to provide an application scheme of a traditional Chinese medicine composition in preparing a bathing agent, and the bathing agent has obvious effects of clearing heat, cooling blood, diminishing inflammation and relieving itching.
The application scheme of the traditional Chinese medicine composition in preparing the bath agent is that in the process of preparing the bath agent, a compound traditional Chinese medicine extract is added into the bath agent as a sole active component with the functions of clearing heat and cooling blood, diminishing inflammation and relieving itching, wherein the compound traditional Chinese medicine extract is a clinopodium polycephalum extract, a perilla leaf extract, a patrinia scabiosaefolia bunge extract, a sweet wormwood herb extract, a glabrous sarcandra herb extract, a suberect spatholobus stem extract, a amur corktree bark extract, a herba siegesbeckiae extract, a lycopodium clavatum extract, a cinnamon extract and a ginger extract, and the mass ratio of the clinopodium polycephalum extract, the perilla leaf extract, the patrinia scabiosaefolia bunge herb extract, the sweet wormwood herb extract, the glabrous sarcandra herb extract, the suberect spatholobus stem extract, the amur corktree bark extract.
In the above technical solution, a more specific solution may also be: the clinopodium polycephalum extract, the perilla leaf extract, the patrinia herb extract, the sweet wormwood herb extract, the glabrous sarcandra herb extract, the suberect spatholobus stem extract, the amur corktree bark extract, the siegesbeckia herba extract, the lycopodium clavatum extract, the cinnamon extract and the ginger extract are used as the only active ingredients with the effects of clearing heat, cooling blood, diminishing inflammation and relieving itching in the process of preparing the shower gel, and the clinopodium polycephalum extract, the perilla leaf extract, the patrinia herb extract, the sweet wormwood herb extract, the glabrous sarcandra herb extract, the suberect spatholobus stem extract, the amur corktree bark extract, the siegesbeck.
Furthermore, the clinopodium polycephalum extract, the perilla leaf extract, the patrinia scabiosaefolia bunge extract, the artemisia apiacea extract, the glabrous sarcandra herb extract, the suberect spatholobus stem extract, the amur corktree bark extract, the siegesbeckia herba extract, the common clubmoss herb extract, the cinnamon extract and the ginger extract are used as the only active ingredients with the effects of clearing heat, cooling blood, diminishing inflammation and relieving itching in the process of preparing the bath powder, and the clinopodium polycephalum extract, the perilla leaf extract, the patrinia scabiosaefolia bunge extract, the artemisia apiacea extract, the glabrous sarcandra herb extract, the suberect spatholobus stem extract, the amur corktree bark.
The Clinopodium polycephalum is dry overground part of a Labiatae plant, namely Cliro podium polycephalum (Vani-ot) C.Y.Wu et Hsuan, or Clinopodium chinensis (Benth) Q.Kuntze, and the extract of the Clinopodium polycephalum has the effects of astringing to stop bleeding, cooling blood and activating blood.
The Perilla leaf is the leaf part of a Perilla (L.) herb Britt belonging to the Labiatae family, the extract of the Perilla leaf contains cinnamaldehyde and other chemical components such as phenols, organic acids and glycosides, and the Perilla leaf has the effects of sweating, expelling muscles and warming and dredging meridians and collaterals, and has the effects of bacteriostasis, hemostasis, antioxidation and the like.
The herba patriniae is the whole grass part of Patrinia scabiosaefolia FISCH (Patrinia scabiosaefolia Fisch) or Patrinia villosa Juss (Patrinia villosa Juss) which belongs to the Patrinia family, and the extract of the herba patriniae has the effects of clearing away heat and toxic materials, removing stasis and expelling pus, clearing sores and relieving pain and the like, and has the functions of bacteriostasis and antivirus.
The sweet wormwood of the invention is the dry aerial part of sweet wormwood (Artemisia carvifolia L) of Compositae, and the extract of the sweet wormwood has the effects of clearing heat and cooling blood, clearing summer heat and preventing malaria; and has good effects of resisting pathogenic microorganism, resisting endotoxin, resisting bacteria and diminishing inflammation; the volatile oil also has effect in killing tinea.
The glabrous Sarcandra herb is a dry whole herb of Sarcandra glabra (Thunb.) Nakai) of the cymbidium, and the extract of the glabrous Sarcandra herb has the effects of clearing heat and cooling blood, promoting blood circulation and removing spots, and dispelling wind and dredging collaterals; and has good antibacterial, antiviral and antiinflammatory effects.
The caulis spatholobi is a dried rhizome of Spatholobus suberectus Dunn of leguminosae, and an extract of the caulis spatholobi has the effects of promoting blood circulation, enriching blood, regulating menstruation, relieving pain, relaxing tendons and activating collaterals; and has anti-inflammatory and immune system regulating effects.
The Phellodendron bark of the invention is the dry bark of Phellodendron chinense (Phellodendron chinense Schneid.) of Rutaceae, and the extract of the Phellodendron bark has the effects of clearing heat, drying dampness, detoxifying, curing sore, purging fire and removing steam; and has effects in resisting pathogenic microorganism, resisting inflammation, relieving fever, resisting oxidation, and resisting ulcer.
The Siegesbeckia orientalis L of the invention is the dry overground part of Siegesbeckia orientalis L, Siegesbeckia glandulifera Makino or Siegesbeckia glabrescens Makino of the compositae, and the extract has the effects of clearing heat and removing toxicity, expelling rheumatism and benefiting joints; and has antiinflammatory, herpesvirus resisting, and antibacterial effects.
The Lycopodium clavatum is dry whole grass of Lycopodium jaPonicum Thunb of Lycopodium clavatum, and the extract of the Lycopodium clavatum has the effects of dispelling wind, removing dampness, relaxing muscles and tendons and activating collaterals; and has antibacterial, antiinflammatory, analgesic, and antioxidant effects.
The cinnamon is dry bark of cinnamon (cinnamon cassia Presl) of Lauraceae, and the extract of the cinnamon has the effects of tonifying fire, supporting yang, guiding fire to origin, dispelling cold, relieving pain and warming and dredging channels; and has antipyretic and analgesic effects.
The ginger is fresh rhizome of Zingiber officinale Rosc of Zingiberaceae, and the extract has the effects of inducing sweat and relieving exterior syndrome; and has good effects of resisting inflammation, relieving fever, resisting bacteria, relieving pain, resisting ulcer, etc.
The extraction method of the traditional Chinese medicine comprises the following steps: according to the traditional Chinese medicine extract: extracting the mixed raw medicinal materials in a mass ratio of 1: 2-1: 5.
The traditional Chinese medicine composition is added in the preparation process of the bath agent product disclosed by the invention as an active ingredient, so that the bath agent product is safe to use, has remarkable anti-inflammation and itching-relieving effects and heat-clearing, blood-cooling and degerming effects, can be used for removing miliaria and skin rash, resisting allergy, reducing the irritation of the product, preventing the micro-ecological environment of the skin from being unbalanced, has the effects of regulating and protecting the skin, can be used daily, and is simple and convenient to prepare.
Detailed Description
The invention is further illustrated by the following examples in which the percentages referred to are by weight unless otherwise indicated.
The components and weight percentage of the shower gel in the examples 1 to 10 are shown in the following table 1:
in the following embodiments, the traditional Chinese medicine extracts in the traditional Chinese medicine anti-inflammatory and antipruritic components are a bloodstream extract, a perilla leaf extract, a patrinia herb extract, a sweet wormwood herb extract, a glabrous sarcandra herb extract, a caulis spatholobi extract, a cortex phellodendri extract, a herba siegesbeckiae extract, a lycopodium clavatum extract, a cinnamon extract and a ginger extract, which are used as the only active components for anti-inflammatory and antipruritic effects in the soap preparation process, and the clinopodium herb extract, the perilla leaf extract, the patrinia herb extract, the sweet wormwood herb extract, the glabrous sarcandra herb extract, the caulis spatholobi extract, the cortex phellodendri extract, the herba siegesbeckiae extract, the: 0:0:0:0:0:0:0:0:0: 0; in embodiments 2 to 7, the ratio of each Chinese medicinal extract is as follows: 1:2:2:1:3:2:3:2:2:1: 1; in example 8, the ratio of each herbal extract was in the order described above: 1:0:0:1:3:2:3:2:2:1: 1; in example 9, the ratio of each herbal extract was in the order described above: 1:2:2:0:0:2:3:2:2:1: 1; in example 10, the ratio of each herbal extract is, in the order mentioned: 1:2:2:1:3:2:0:2:2:1:1.
The raw materials and the weight percentage of the bath powder in the examples 11 to 20 are shown in the following table 2:
in the following embodiments, the traditional Chinese medicine extracts in the traditional Chinese medicine anti-inflammatory and antipruritic components are a bloodstream extract, a perilla leaf extract, a patrinia herb extract, a sweet wormwood herb extract, a glabrous sarcandra herb extract, a caulis spatholobi extract, a cortex phellodendri extract, a herba siegesbeckiae extract, a lycopodium clavatum extract, a cinnamon extract and a ginger extract, which are used as the only active components for anti-inflammatory and antipruritic effects in the soap preparation process, and the clinopodium herb extract, the perilla leaf extract, the patrinia herb extract, the sweet wormwood herb extract, the glabrous sarcandra herb extract, the caulis spatholobi extract, the cortex phellodendri extract, the herba siegesbeckiae extract, the: 0:0:0:0:0:0:0:0:0: 0; in examples 12 to 16, the ratio of each herb extract is, in the order mentioned above: 1:2:2:1:3:2:3:2:2:1: 1; in example 17, the ratio of each herbal extract was in the order described above: 1:0:0:1:3:2:3:2:2:1: 1; in example 18, the ratio of each herbal extract was in the order described above: 1:2:2:0:0:2:3:2:2:1: 1; in example 19, the ratio of each herbal extract was in the order described above: 1:2:2:1:3:2:0:2:2:1:1.
Table 2:
clinical experimental part:
1. bacteriostasis experiments (tests according to the bacteriostasis rate method in the sanitary Standard of Disposable sanitary articles GB 15979). As shown in table 3
The results in table 3 show that in examples 2-7 and examples 12-16, the compound traditional Chinese medicine extract and the bath agent prepared from the extract have better inhibitory action on staphylococcus aureus and faecal coliform, and the antibacterial action is more obvious along with the increase of the proportion of the compound traditional Chinese medicine extract; in examples 8-10 and 17-19, the same percentage of compound herbal extracts were taken, but each herbal extract was depleted in one or two of the herbal extracts, which reduced the inhibitory effect on staphylococcus aureus and faecal coliform.
2. Anti-inflammatory action test
Animal experiment of bathing agent for clearing heat, cooling blood and removing bacteria
Experimental animals: white mouse, weight 18-22 g.
Test drugs: fluocinonide cream; examples 1, 3, 5, 7, 10, 11, 13, 15, 17, and 19 of this patent.
The test method comprises the following steps: anti-inflammatory effect of acute inflammation swelling of auricle of mice caused by paraxylene.
Table 4:
the experimental results show that the samples in examples 3, 5, 7, 12, 13 and 15 have obvious anti-inflammatory effect, the samples in examples 1 and 11 (without adding traditional Chinese medicine components) have no obvious anti-inflammatory effect, and the samples in examples 8, 10, 17 and 19 use the same percentage of compound traditional Chinese medicine extracts, but each traditional Chinese medicine extract has less two traditional Chinese medicine extracts, so that the anti-inflammatory effect is reduced.
3. Test for antipruritic action
Animal experiment of bathing agent for clearing heat, cooling blood and removing bacteria
Experimental animals: hartley guinea pigs weighing 250-400 g.
Test drugs: three heat-clearing and itching-relieving lotions; examples 1, 3, 4, 5, 8, 9, 10, 13, 14, 16 and 18 of this patent.
The test method comprises the following steps: effect on histamine phosphate antipruritic response in Hartley guinea pigs.
Table 5:
experimental results show that examples 3, 4, 5, 13, 14 and 16 have obvious itching relieving effect, example 1 (without adding traditional Chinese medicine components) has no obvious itching relieving effect, examples 8, 9 and 10 have the same percentage of compound traditional Chinese medicine extracts adopted in example 18, but each traditional Chinese medicine extract has less two traditional Chinese medicine extracts, and the itching relieving effect is reduced.
To summarize: the 11 traditional Chinese medicine extracts of the invention must be correctly used in the bath agent in proportion, any one of the 11 traditional Chinese medicine extracts is omitted, and the anti-inflammation, itching relieving and bacteriostasis of the 11 traditional Chinese medicine extracts can not meet the requirements.
Claims (3)
1. The application of the traditional Chinese medicine composition in preparing the bath agent is that in the process of preparing the bath agent, a compound traditional Chinese medicine extract is added into the bath agent as a sole active component with the effects of clearing heat and cooling blood, diminishing inflammation and relieving itching, wherein the compound traditional Chinese medicine extract is a clinopodium polycephalum extract, a perilla leaf extract, a patrinia herb extract, a sweet wormwood herb extract, a glabrous sarcandra herb extract, a suberect spatholobus stem extract, a amur corktree bark extract, a herba siegesbeckiae extract, a lycopodium clavatum extract, a cinnamon extract and a ginger extract, and the mass ratio of the clinopodium polycephalum extract, the perilla leaf extract, the patrinia herb extract, the sweet wormwood herb extract, the glabrous sarcandra herb extract, the suberect spatholobus stem extract, the amur corktree bark extract, the herba siegesbeckiae.
2. The use of the Chinese medicinal composition according to claim 1 in the preparation of a bathing agent, wherein: the clinopodium polycephalum extract, the perilla leaf extract, the patrinia herb extract, the sweet wormwood herb extract, the glabrous sarcandra herb extract, the suberect spatholobus stem extract, the amur corktree bark extract, the siegesbeckia herba extract, the lycopodium clavatum extract, the cinnamon extract and the ginger extract are used as the only active ingredients with the effects of clearing heat, cooling blood, diminishing inflammation and relieving itching in the process of preparing the shower gel, and the clinopodium polycephalum extract, the perilla leaf extract, the patrinia herb extract, the sweet wormwood herb extract, the glabrous sarcandra herb extract, the suberect spatholobus stem extract, the amur corktree bark extract, the siegesbeck.
3. The use of the Chinese medicinal composition according to claim 1 in the preparation of a bathing agent, wherein: the clinopodium polycephalum extract, the perilla leaf extract, the patrinia herb extract, the sweet wormwood herb extract, the glabrous sarcandra herb extract, the suberect spatholobus stem extract, the amur corktree bark extract, the siegesbeckia herba extract, the lycopodium clavatum extract, the cinnamon extract and the ginger extract are used as the only active ingredients with the functions of clearing heat, cooling blood, diminishing inflammation and relieving itching in the process of preparing the bath powder, and the clinopodium polycephalum extract, the perilla leaf extract, the patrinia herb extract, the sweet wormwood herb extract, the glabrous sarcandra herb extract, the suberect spatholobus stem extract, the amur corktree bark extract, the siegesbeckia herba extract, the common clubm.
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| CN109330958A (en) | 2019-02-15 |
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