CN105432885A - Dried tangerine or orange peel tea dropping pill and preparation method thereof - Google Patents
Dried tangerine or orange peel tea dropping pill and preparation method thereof Download PDFInfo
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- CN105432885A CN105432885A CN201510903735.XA CN201510903735A CN105432885A CN 105432885 A CN105432885 A CN 105432885A CN 201510903735 A CN201510903735 A CN 201510903735A CN 105432885 A CN105432885 A CN 105432885A
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
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Abstract
The invention discloses a dried tangerine or orange peel tea dropping pill. The dried tangerine or orange peel tea dropping pill is prepared from, by mass, 5-8 parts of dried tangerine or orange peel extracted concentrated liquor, 1-2 parts of fish skin gelatin, 40-45 parts of polyoxyethylene (40) stearate and 0.1-0.4 part of polysorbate 80. The invention also discloses a preparation method of the dried tangerine or orange peel dropping pill. According to the preparation method, the dried tangerine or orange peel extracted concentrated liquor is prepared, gelatin in fish skin is extracted, and weighing and granulation are performed. The dropping pill is convenient to produce and carry, capable of being taken instantly, suitable for both old and young people and convenient to use; after drugs prone to oxidation and volatilization in herbal tea are dissolved in a matrix, stability of the drugs is enhanced; meanwhile, the taste of the herbal tea is covered, and the dropping pill is more suitable for children, old people and office workers. The dropping pill has the functions of invigorating the stomach to help digestion, losing weight and lowering blood fat.
Description
Technical field
The invention belongs to health protection tea preparing technical field, be specifically related to a kind of orange peel tea dripping pill, the invention still further relates to a kind of preparation method of orange peel tea dripping pill.
Background technology
Orange peel tea is a kind of folks of china Chinese traditional herbs, one of cold tea that Cantonese often drinks.The inside composition comprises dried orange peel and tealeaves etc., utilizes dried orange peel and tealeaves to carry out split, the orange peel tea of making, can be referred to as " medicinal herb tea ".The i.e. property of medicine health-care effect the first of orange peel tea, the object that tea ceremony is tasted is anti-secondarily.Often drink orange peel tea, have and relieve summer heat summer, relieving cough and reducing sputum, the health cares such as strengthening spleen and nourishing stomach, can also treat the diseases such as the taste stagnation of the circulation of vital energy, abdominal distension stomachache, indigestion, poor appetite.Also prevention effect is had to diseases such as high fat of blood, hypertension, fatty liver, myocardial infarctions.This is a out and out health protection tea.
At present, the use for orange peel tea generally still rests on traditional cold tea and decocts, and use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of orange peel tea is obviously reduced simultaneously, greatly hinders the promotion and application of orange peel tea.
Pill has the following feature: 1, equipment simple, easy to operate, be beneficial to labour protection, process cycle is short, productivity ratio is high; 2, process conditions are easy to control, steady quality, and dosage is accurate, and heated time is short, after the volatile medicine of oxidizable and tool is dissolved in matrix, can increase its stability; 3, matrix holds liquid drug amount greatly, therefore liquid drug can be made to solidify; 4, have the advantages that absorption is rapid, bioavilability is high with dripping pill prepared by solid dispersion technology.Inclusion compound has the following advantages: cover bad stink, reduces excitant; Increase drug dissolution and bioavilability; Improve medicine stability.
Cold tea is as Chinese tradition drink, and the cold tea paving big and small in In Guangdong Province is seen everywhere, and pouplarity has some idea of.But traditional herb tea decocts to waste time and energy, the rhythm of life of urbanite is but more and more faster now, and younger generation few people are ready to buy specially a watt pot and spend several hours and go decoction one to take cold tea.Meanwhile, in cold tea, there is the oxidizable and volatile medicine of tool, be not easy to preserve; Cold tea bitter, is not easy to be accepted by people especially the younger generation.
Summary of the invention
The object of this invention is to provide a kind of orange peel tea dripping pill, the active ingredient solved in the not portable and orange peel tea of the orange peel tea existed in prior art is difficult to the problem extracted.
Another object of the present invention is to provide a kind of preparation method of orange peel tea dripping pill.
First technical scheme of the present invention is, a kind of orange peel tea dripping pill, comprises following component according to mass parts: dried orange peel extracts concentrate 5-8 part, fishskin gelatin 1-2 part, polyoxyethylene stearate (40) ester 40 parts-45 parts, polyoxyethylene sorbitan monoleate 0.1 part-0.4 part.
Further, dried orange peel is extracted concentrate and is prepared by following steps: dried orange peel is carried out removal of contamination and cleans, dry, by means of sunning sterilization, and carry out frying and pulverizing, add water, and adjusts pH to 8-10, joins CO
2in supercritical extract device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 12-15%, extracting pressure 55-65MPa, temperature 45-60 DEG C, CO
2flow 3-5m1/g crude drug .min, extraction time 4-8h, obtains supercritical extract, add the ethanolic solution of 95%, soak 20h-28h, add hot reflux 2h-3h, then filter under normal temperature and pressure, obtain leaching liquid, reduced pressure concentration is carried out to leaching liquid and obtains blackish green medicinal extract, be alcohol extraction liquid, concentrated, be added on LSA-900C large pore resin absorption column, 50% ethanol elution, collects 6 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain dried orange peel extraction concentrate.
Further, the gelatin extracted in fish-skin is specially: freezing fish-skin shreds, thaws, cleans, after carrying out degreasing, with 0.25%-0.4% hydrochloric acid solution process 3-5h, be washed to neutrality or slant acidity, glue 3-6h is carried under 30-50 DEG C of condition, after filtering skin slag, through glue purification, concentrated, dry, obtain fishskin gelatin finished product, wherein, degreasing condition is: 40 ~ 45 DEG C, 0.3% sodium chloride solution rinsing raw material 1h.
Second technical scheme of the present invention is, a kind of preparation method of orange peel tea dripping pill, comprises the following steps:
Step 1, prepare dried orange peel extract concentrate;
Step 2, the gelatin extracted in fish-skin;
Step 3, weighing: weigh following component according to mass parts: dried orange peel extracts concentrate 5-8 part, fishskin gelatin 1-2 part, polyoxyethylene stearate (40) ester 40 parts-45 parts, polyoxyethylene sorbitan monoleate 0.1 part-0.4 part;
Step 4, the melting at 70 ~ 100 DEG C by polyoxyethylene stearate (40) ester and polyoxyethylene sorbitan monoleate, extract concentrate and fishskin gelatin be well dispersed in matrix by preparing gained dried orange peel, be placed in heating container and heat while stirring, until the fused solution obtaining extracting containing dried orange peel concentrate, fishskin gelatin and matrix is for subsequent use; The temperature control system of adjustment pill dripping machine, makes the water dropper of pill dripping machine heat and maintains the temperature at 60 DEG C ~ 70 DEG C, adopts atoleine cooling fluid carry out condensation and maintain the temperature at 30 DEG C ~ 5 DEG C; When pill dripping machine water dropper and condensing agent reach described state of temperature respectively, by the fused solution containing described extract, polyoxyethylene stearate (40) ester and polyoxyethylene sorbitan monoleate, be placed in the water dropper tank of pill dripping machine, shrink shaping in instillation condensing agent, to obtain final product.
Further, prepare dried orange peel extraction concentrate to be specially: dried orange peel is carried out removal of contamination and cleans, dry, by means of sunning sterilization, and carry out frying and pulverizing, add water, adjust pH to 8-10, join CO
2in supercritical extract device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 12-15%, extracting pressure 55-65MPa, temperature 45-60 DEG C, CO
2flow 3-5m1/g crude drug .min, extraction time 4-8h, obtains supercritical extract, add the ethanolic solution of 95%, soak 20h-28h, add hot reflux 2h-3h, then filter under normal temperature and pressure, obtain leaching liquid, reduced pressure concentration is carried out to leaching liquid and obtains blackish green medicinal extract, be alcohol extraction liquid, concentrated, be added on LSA-900C large pore resin absorption column, 50% ethanol elution, collects 6 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain dried orange peel extraction concentrate.
Further, the gelatin extracted in fish-skin is specially: freezing fish-skin shreds, thaws, cleans, after carrying out degreasing, with 0.25%-0.4% hydrochloric acid solution process 3-5h, be washed to neutrality or slant acidity, under 30-50 DEG C of condition, carry glue 3-6h, after filtering skin slag, through glue purification, concentrated, dry, obtain fishskin gelatin finished product.
Further, degreasing condition is: 40 ~ 45 DEG C, 0.3% sodium chloride solution rinsing raw material 1h.
The invention has the beneficial effects as follows: drops is used for, in traditional herb tea, solving the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of cold tea greatly.Be convenient to produce and carry, namely rush namely with, old and young suitable, have easy to use; Its stability is increased after the volatile medicine of oxidizable and tool in cold tea is dissolved in matrix; Mask the taste of cold tea simultaneously, be more suitable for children, old man and working clan use.Dripping pill of the present invention has the function of stomach strengthening and digestion promoting, reducing weight and blood fat.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in detail.
The invention provides a kind of orange peel tea dripping pill, comprise following component according to mass parts: dried orange peel extracts concentrate 5-8 part, fishskin gelatin 1-2 part, polyoxyethylene stearate (40) ester 40 parts-45 parts, polyoxyethylene sorbitan monoleate 0.1 part-0.4 part.
The present invention also provides a kind of preparation method of orange peel tea dripping pill, comprises the following steps:
Step 1, prepare dried orange peel extract concentrate: dried orange peel is carried out removal of contamination and cleans, dries, by means of sunning sterilization, and carry out frying and pulverizing, add water, adjust pH to 8-10, join CO
2in supercritical extract device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 12-15%, extracting pressure 55-65MPa, temperature 45-60 DEG C, CO
2flow 3-5m1/g crude drug .min, extraction time 4-8h, obtains supercritical extract, add the ethanolic solution of 95%, soak 20h-28h, add hot reflux 2h-3h, then filter under normal temperature and pressure, obtain leaching liquid, reduced pressure concentration is carried out to leaching liquid and obtains blackish green medicinal extract, be alcohol extraction liquid, concentrated, be added on LSA-900C large pore resin absorption column, 50% ethanol elution, collects 6 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain dried orange peel extraction concentrate;
Step 2, the gelatin extracted in fish-skin: freezing fish-skin shreds, thaws, cleans, after carrying out degreasing, with 0.25%-0.4% hydrochloric acid solution process 3-5h, be washed to neutrality or slant acidity, glue 3-6h is carried under 30-50 DEG C of condition, after filtering skin slag, through glue purification, concentrated, dry, obtain gelatin finished product.
Wherein, degreasing condition is: 40 ~ 45 DEG C, 0.3% sodium chloride solution rinsing raw material 1h, and fish-skin fat residual quantity is 0.64%, and fatty removal efficiency reaches 95.65%;
Step 3, weighing: weigh following component according to mass parts: dried orange peel extracts concentrate 5-8 part, fishskin gelatin 1-2 part, polyoxyethylene stearate (40) ester 40 parts-45 parts, polyoxyethylene sorbitan monoleate 0.1 part-0.4 part;
Step 4, the melting at 70 ~ 100 DEG C by polyoxyethylene stearate (40) ester and polyoxyethylene sorbitan monoleate, extract concentrate and fishskin gelatin be well dispersed in matrix by preparing gained dried orange peel, be placed in heating container and heat while stirring, until the fused solution obtaining extracting containing dried orange peel concentrate, fishskin gelatin and matrix is for subsequent use; The temperature control system of adjustment pill dripping machine, makes the water dropper of pill dripping machine heat and maintains the temperature at 60 DEG C ~ 70 DEG C, adopts atoleine cooling fluid carry out condensation and maintain the temperature at 30 DEG C ~ 5 DEG C; When pill dripping machine water dropper and condensing agent reach described state of temperature respectively, by the fused solution containing described extract, polyoxyethylene stearate (40) ester and polyoxyethylene sorbitan monoleate, be placed in the water dropper tank of pill dripping machine, shrink shaping in instillation condensing agent, to obtain final product.
Wherein, can promoting digestion and removing indigestion, promoting blood circulation to remove blood stasis, antidiarrheal, cardiac stimulant anti-arrhythmia, increases coronary artery blood volume, and expansion peripheral vascular, reduces blood pressure, serum cholesterol-lowering.Being used for the treatment of food stagnantly not change---indigestion, poor appetite, abdominal fullness and distention, stomachache are had loose bowels and hypertension, hyperlipidemia, coronary heart diseases and angina pectoris.There is cardiac stimulant coronary artery dilator, strengthen coronary flow and lasting hypotensive effect, the secretion of enzyme in stomach can be increased, promote its fatty acids of digestion, the digestion of fatty dyspepsia can be promoted.
Embodiment 1
A preparation method for orange peel tea dripping pill, comprises the following steps: dried orange peel is carried out removal of contamination and cleans, dry, and by means of sunning sterilization, and carries out frying and pulverizing, adds water, and adjusts pH to 9, joins CO
2in supercritical extract device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 14%, extracting pressure 60MPa, temperature 55 DEG C, CO
2flow 4m1/g crude drug .min, extraction time 6h, obtains supercritical extract, add the ethanolic solution of 95%, soak 24h, add hot reflux 2.5h, then filter under normal temperature and pressure, obtain leaching liquid, reduced pressure concentration is carried out to leaching liquid and obtains blackish green medicinal extract, be alcohol extraction liquid, concentrated, be added on LSA-900C large pore resin absorption column, 50% ethanol elution, collects 6 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain dried orange peel extraction concentrate; Freezing fish-skin shreds, thaws, cleans, and after carrying out degreasing, with 0.3% hydrochloric acid solution process 3-5h, is washed to neutrality or slant acidity, carries glue 4.5h under 40 DEG C of conditions, after filtering skin slag, through glue purification, concentrated, dry, obtains gelatin finished product; Wherein, degreasing condition is: 43 DEG C, 0.3% sodium chloride solution rinsing raw material 1h, and fish-skin fat residual quantity is 0.64%, and fatty removal efficiency reaches 95.65%; Following component is weighed: dried orange peel extracts concentrate 6.5 parts, fishskin gelatin 1.5 parts, polyoxyethylene stearate (40) ester 43 parts, polyoxyethylene sorbitan monoleate 0.25 part according to mass parts; The melting at 85 DEG C by polyoxyethylene stearate (40) ester and polyoxyethylene sorbitan monoleate, extract concentrate and fishskin gelatin be well dispersed in matrix by preparing gained dried orange peel, be placed in heating container and heat while stirring, until the fused solution obtaining extracting containing dried orange peel concentrate, fishskin gelatin and matrix is for subsequent use; The temperature control system of adjustment pill dripping machine, makes the water dropper of pill dripping machine heat and maintains the temperature at 65 DEG C, adopts atoleine cooling fluid carry out condensation and maintain the temperature at 15 DEG C; When pill dripping machine water dropper and condensing agent reach described state of temperature respectively, by the fused solution containing described extract, polyoxyethylene stearate (40) ester and polyoxyethylene sorbitan monoleate, be placed in the water dropper tank of pill dripping machine, shrink shaping in instillation condensing agent, to obtain final product.
Embodiment 2
A preparation method for orange peel tea dripping pill, comprises the following steps: dried orange peel is carried out removal of contamination and cleans, dry, and by means of sunning sterilization, and carries out frying and pulverizing, adds water, and adjusts pH to 8, joins CO
2in supercritical extract device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 12%, extracting pressure 55MPa, temperature 45 C, CO
2flow 3m1/g crude drug .min, extraction time 4h, obtains supercritical extract, add the ethanolic solution of 95%, soak 20h, add hot reflux 2h, then filter under normal temperature and pressure, obtain leaching liquid, reduced pressure concentration is carried out to leaching liquid and obtains blackish green medicinal extract, be alcohol extraction liquid, concentrated, be added on LSA-900C large pore resin absorption column, 50% ethanol elution, collects 6 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain dried orange peel extraction concentrate; Freezing fish-skin shreds, thaws, cleans, and after carrying out degreasing, with 0.25% hydrochloric acid solution process 3h, is washed to neutrality or slant acidity, carries glue 3h under 30 DEG C of conditions, after filtering skin slag, through glue purification, concentrated, dry, obtains gelatin finished product; Wherein, degreasing condition is: 40 DEG C, 0.3% sodium chloride solution rinsing raw material 1h, and fish-skin fat residual quantity is 0.64%, and fatty removal efficiency reaches 95.65%; Following component is weighed: dried orange peel extracts concentrate 5 parts, fishskin gelatin 2 parts, polyoxyethylene stearate (40) ester 40 parts, polyoxyethylene sorbitan monoleate 0.4 part according to mass parts; The melting at 70 DEG C by polyoxyethylene stearate (40) ester and polyoxyethylene sorbitan monoleate, extract concentrate and fishskin gelatin be well dispersed in matrix by preparing gained dried orange peel, be placed in heating container and heat while stirring, until the fused solution obtaining extracting containing dried orange peel concentrate, fishskin gelatin and matrix is for subsequent use; The temperature control system of adjustment pill dripping machine, makes the water dropper of pill dripping machine heat and maintains the temperature at 60 DEG C, adopts atoleine cooling fluid carry out condensation and maintain the temperature at 30 DEG C; When pill dripping machine water dropper and condensing agent reach described state of temperature respectively, by the fused solution containing described extract, polyoxyethylene stearate (40) ester and polyoxyethylene sorbitan monoleate, be placed in the water dropper tank of pill dripping machine, shrink shaping in instillation condensing agent, to obtain final product.
Embodiment 3
A preparation method for orange peel tea dripping pill, comprises the following steps: dried orange peel is carried out removal of contamination and cleans, dry, and by means of sunning sterilization, and carries out frying and pulverizing, adds water, and adjusts pH to 10, joins CO
2in supercritical extract device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 15%, extracting pressure 65MPa, temperature 60 C, CO
2flow 5m1/g crude drug .min, extraction time 8h, obtains supercritical extract, add the ethanolic solution of 95%, soak 28h, add hot reflux 3h, then filter under normal temperature and pressure, obtain leaching liquid, reduced pressure concentration is carried out to leaching liquid and obtains blackish green medicinal extract, be alcohol extraction liquid, concentrated, be added on LSA-900C large pore resin absorption column, 50% ethanol elution, collects 6 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain dried orange peel extraction concentrate; Freezing fish-skin shreds, thaws, cleans, and after carrying out degreasing, with 0.4% hydrochloric acid solution process 3-5h, is washed to neutrality or slant acidity, carries glue 6h under 50 DEG C of conditions, after filtering skin slag, through glue purification, concentrated, dry, obtains gelatin finished product; Wherein, degreasing condition is: 45 DEG C, 0.3% sodium chloride solution rinsing raw material 1h, and fish-skin fat residual quantity is 0.64%, and fatty removal efficiency reaches 95.65%; Following component is weighed: dried orange peel extracts concentrate 8 parts, fishskin gelatin 1 part, polyoxyethylene stearate (40) ester 45 parts, polyoxyethylene sorbitan monoleate 0.1 part according to mass parts; The melting at 100 DEG C by polyoxyethylene stearate (40) ester and polyoxyethylene sorbitan monoleate, extract concentrate and fishskin gelatin be well dispersed in matrix by preparing gained dried orange peel, be placed in heating container and heat while stirring, until the fused solution obtaining extracting containing dried orange peel concentrate, fishskin gelatin and matrix is for subsequent use; The temperature control system of adjustment pill dripping machine, makes the water dropper of pill dripping machine heat and maintains the temperature at 70 DEG C, adopts atoleine cooling fluid carry out condensation and maintain the temperature at 5 DEG C; When pill dripping machine water dropper and condensing agent reach described state of temperature respectively, by the fused solution containing described extract, polyoxyethylene stearate (40) ester and polyoxyethylene sorbitan monoleate, be placed in the water dropper tank of pill dripping machine, shrink shaping in instillation condensing agent, to obtain final product.
Comparative example:
The dripping pill that common process prepares.
Below in conjunction with dissolving time limit, subjective appreciation, hardness, outward appearance and drug effect evaluate beneficial effect of the present invention:
1, the test of pesticide effectiveness
1.1, the routine patient of clinical observation 60, treatment group 30 example, control group 30 example.Whole case history all meets case selection standard, man 36 example, female 24 example, age 35-48 year, the course of disease is the shortest 2 days, the longest 2 weeks, takes five-flowered tea dripping pill one week.
Diagnosis basis: the standard that disconnected standard is demonstrate,proved based on anemopyretic cold relevant in " disease of tcm Standardization of diagnosis and curative effect ", 1. heating, micro-aversion to wind and cold, nasal obstruction runny nose, sneeze, headache, general malaise.2. pink tongue or limit point red, platform book is yellow, superficial and rapid pulse.3. unusual weather conditions or daily life cause accidentally, sudden onset.
Symptom and sign ranking criterion: according to correlation intergal standard in " traditional Chinese medical science Clinical Researches of New Drugs guideline ", the disappearance of headache, bodily pain, runny nose, pharyngalgia, congestion of throat, cough, slight, moderate, severe long-pending 0,1,2,3 point respectively.
Inclusive criteria: meet traditional Chinese medical science anemopyretic cold card diagnostic criteria, body temperature is no more than 39 DEG C of persons, and the course of disease is person within 48h, and the age is between 18 ~ 65 years old.
Excluded cases standard: used medicine person as antibiotic, hormone or other cold medicines person or the person that do not bring down a fever; Merge other primary disease persons of lung, as pulmonary tuberculosis, lung swelling and pain person; Merge serious cardiovascular, liver, kidney and disease of hematopoietic system person; Age is under-18s or over-65s person or be the gestational period, women breast-feeding their children, and physique allergy sufferers.
Control group: comparative example dripping pill, 3 times/d, 7d were 1 course for the treatment of.
Criterion of therapeutical effect: cardinal symptom sign curative effect determinate standard temperature decline more than 0.5 DEG C is onset, dropping to 37.4 DEG C is that temperature recovery is normal.Other symptom and sign integrations reduce by 1 and are divided into onset, and 0 is divided into disappearance.Comprehensive therapeutic effect criterion is fully recovered: within treatment 3d, temperature recovery is normal, and sings and symptoms all disappears, or symptom, somatic feature score decline more than 90% person; Effective: within treatment 3d, body temperature is normal, and most of sings and symptoms disappears, or symptom, somatic feature score decline more than 75% person; Effective: treatment 3d within body temperature reduce than before, cardinal symptom and sign partial disappearance, or symptom, somatic feature score decline more than 50% person; Invalid: within treatment 3d, body temperature does not fall or raises, cardinal symptom and sign are without improvement or improve <50%.Treatment results: in table 2.
Contrast with embodiments of the invention 1-3 and comparative example, draw the following conclusions.
Table 1 comparing result
| Dissolve scattered time limit (min) | Formability | Roundness | Fineness | Hardness | |
| Embodiment 1 | 13 | Be shaped | Good | Good | Slightly soft |
| Embodiment 2 | 15 | Be shaped | Better | Good | Good |
| Embodiment 3 | 14 | Be shaped | Better | Good | Good |
| Comparative example | 26 | Shapeless | Difference | Difference | Too soft |
The observation of curative effect of this dripping pill of table 2 treatment anemopyretic cold patient
| Group | Total number of cases | Recovery from illness | Effective | Effectively | Invalid | Total effective rate |
| Embodiment 1 | 30 | 27 | 1 | 1 | 1 | 96.7％ |
| Embodiment 2 | 30 | 16 | 6 | 4 | 4 | 86.7％ |
| Embodiment 3 | 30 | 23 | 1 | 1 | 5 | 83.3％ |
| Comparative example | 30 | 6 | 4 | 4 | 16 | 53.3％ |
As shown in Table 2, illustrate that the effective component ratio in dripping pill of the present invention is easier to extract, dripping pill treatment anemopyretic cold effect of the present invention is higher than existing five-flowered tea dripping pill.
1.2, this dripping pill is on the impact of blood sugar concentration and insulin resistance index
Found through experiments, the immunoloregulation function of this component is not high, but, the Be very effective of its stomach strengthening and digestion promoting, reducing weight and blood fat.Concrete outcome is as follows:
This dripping pill of table 3 significantly can reduce insulin level in serum and blood sugar concentration (P<0.05, P<0.01).Comparative analysis HOMA-IR index (HOMA-IR=blood sugar concentration × insulin content/22.5) finds that the HOMA-IR index of high-fat adiposity group mouse is significantly improved (P<0.05), show to which create insulin resistance, this dripping pill can significantly reduce HOMA-IR index, shows that it very effectively can improve insulin resistance.
This dripping pill of table 3 is on the impact (n=8) of insulin resistance index
Attention: * P<0.05, * * P<0.01vs comparative example
Fat usually can formation type ii diabetes plays certain bringing out and increase the weight of effect.After the high fat high-carbonhydrate diet induction of 5w, can find that high-fat adiposity group mouse occurs the phenomenon that impaired glucose tolerance and serum insulin level rise showing insulin resistance.This dripping pill effectively can improve the resistance to impaired symptom of sugar of mouse, significantly reduces blood sugar concentration and insulin level, illustrates that this product can improve the sensitiveness of insulin, thus have some improvement for IR.
Claims (7)
1. an orange peel tea dripping pill, is characterized in that, comprises following component according to mass parts: dried orange peel extracts concentrate 5-8 part, fishskin gelatin 1-2 part, polyoxyethylene stearate (40) ester 40 parts-45 parts, polyoxyethylene sorbitan monoleate 0.1 part-0.4 part.
2. orange peel tea dripping pill according to claim 1, is characterized in that, described dried orange peel is extracted concentrate and prepared by following steps: dried orange peel is carried out removal of contamination and cleans, dry, by means of sunning sterilization, and carry out frying and pulverizing, add water, adjust pH to 8-10, join CO
2in supercritical extract device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 12-15%, extracting pressure 55-65MPa, temperature 45-60 DEG C, CO
2flow 3-5m1/g crude drug .min, extraction time 4-8h, obtains supercritical extract, add the ethanolic solution of 95%, soak 20h-28h, add hot reflux 2h-3h, then filter under normal temperature and pressure, obtain leaching liquid, reduced pressure concentration is carried out to leaching liquid and obtains blackish green medicinal extract, be alcohol extraction liquid, concentrated, be added on LSA-900C large pore resin absorption column, 50% ethanol elution, collects 6 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain dried orange peel extraction concentrate.
3. orange peel tea dripping pill according to claim 1, it is characterized in that, the gelatin in described extraction fish-skin is specially: freezing fish-skin shreds, thaws, cleans, after carrying out degreasing, with 0.25%-0.4% hydrochloric acid solution process 3-5h, be washed to neutrality or slant acidity, under 30-50 DEG C of condition, carry glue 3-6h, after filtering skin slag, through glue purification, concentrated, dry, obtain fishskin gelatin finished product, wherein, degreasing condition is: 40 ~ 45 DEG C, 0.3% sodium chloride solution rinsing raw material 1h.
4. a preparation method for orange peel tea dripping pill, is characterized in that, comprises the following steps:
Step 1, prepare dried orange peel extract concentrate;
Step 2, the gelatin extracted in fish-skin;
Step 3, weighing: weigh following component according to mass parts: dried orange peel extracts concentrate 5-8 part, fishskin gelatin 1-2 part, polyoxyethylene stearate (40) ester 40 parts-45 parts, polyoxyethylene sorbitan monoleate 0.1 part-0.4 part;
Step 4, the melting at 70 ~ 100 DEG C by polyoxyethylene stearate (40) ester and polyoxyethylene sorbitan monoleate, extract concentrate and fishskin gelatin be well dispersed in matrix by preparing gained dried orange peel, be placed in heating container and heat while stirring, until the fused solution obtaining extracting containing dried orange peel concentrate, fishskin gelatin and matrix is for subsequent use; The temperature control system of adjustment pill dripping machine, makes the water dropper of pill dripping machine heat and maintains the temperature at 60 DEG C ~ 70 DEG C, adopts atoleine cooling fluid carry out condensation and maintain the temperature at 30 DEG C ~ 5 DEG C; When pill dripping machine water dropper and condensing agent reach described state of temperature respectively, by the fused solution containing described extract, polyoxyethylene stearate (40) ester and polyoxyethylene sorbitan monoleate, be placed in the water dropper tank of pill dripping machine, shrink shaping in instillation condensing agent, to obtain final product.
5. the preparation method of orange peel tea dripping pill according to claim 4, is characterized in that, described dried orange peel extraction concentrate of preparing is specially: dried orange peel is carried out removal of contamination and cleans, dry, by means of sunning sterilization, and carry out frying and pulverizing, add water, adjust pH to 8-10, join CO
2in supercritical extract device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 12-15%, extracting pressure 55-65MPa, temperature 45-60 DEG C, CO
2flow 3-5m1/g crude drug .min, extraction time 4-8h, obtains supercritical extract, add the ethanolic solution of 95%, soak 20h-28h, add hot reflux 2h-3h, then filter under normal temperature and pressure, obtain leaching liquid, reduced pressure concentration is carried out to leaching liquid and obtains blackish green medicinal extract, be alcohol extraction liquid, concentrated, be added on LSA-900C large pore resin absorption column, 50% ethanol elution, collects 6 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain dried orange peel extraction concentrate.
6. the preparation method of orange peel tea dripping pill according to claim 4, it is characterized in that, gelatin in described extraction fish-skin is specially: freezing fish-skin shreds, thaws, cleans, after carrying out degreasing, with 0.25%-0.4% hydrochloric acid solution process 3-5h, be washed to neutrality or slant acidity, glue 3-6h is carried under 30-50 DEG C of condition, after filtering skin slag, through glue purification, concentrated, dry, obtain fishskin gelatin finished product.
7. the preparation method of orange peel tea dripping pill according to claim 6, is characterized in that, described degreasing condition is: 40 ~ 45 DEG C, 0.3% sodium chloride solution rinsing raw material 1h.
Priority Applications (1)
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116889269A (en) * | 2023-07-20 | 2023-10-17 | 厚德祖康生物制药有限公司 | Chinese medicinal solid beverage for improving immunity of human body |
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| CN103540142A (en) * | 2013-09-29 | 2014-01-29 | 宁波大学 | Edible squid skin gelatin composite film and preparation method thereof |
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| CN1872048A (en) * | 2006-04-25 | 2006-12-06 | 邵爱霞 | Drop pills of soybean aglycone, and preparation method |
| CN101703136A (en) * | 2009-11-03 | 2010-05-12 | 林炳光 | Method for preparing orange peel tea |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116889269A (en) * | 2023-07-20 | 2023-10-17 | 厚德祖康生物制药有限公司 | Chinese medicinal solid beverage for improving immunity of human body |
| CN116889269B (en) * | 2023-07-20 | 2024-04-16 | 厚德祖康生物制药有限公司 | Chinese medicinal solid beverage for improving immunity of human body |
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