CN105432886A - 24-flavor herbal tea effervescent tablet and preparation method thereof - Google Patents

24-flavor herbal tea effervescent tablet and preparation method thereof Download PDF

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Publication number
CN105432886A
CN105432886A CN201510903908.8A CN201510903908A CN105432886A CN 105432886 A CN105432886 A CN 105432886A CN 201510903908 A CN201510903908 A CN 201510903908A CN 105432886 A CN105432886 A CN 105432886A
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parts
cold tea
taste cold
taste
dry powder
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刘其礼
张学思
廖明生
吴晓玲
保泽庆
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Zhaoqing Medical Higher College
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Zhaoqing Medical Higher College
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23FCOFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00Tea; Tea substitutes; Preparations thereof
    • A23F3/34Tea substitutes, e.g. matè; Extracts or infusions thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • AHUMAN NECESSITIES
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/35Caprifoliaceae (Honeysuckle family)
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    • A61K36/605Morus (mulberry)
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007Effervescent
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    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a 24-flavor herbal tea effervescent tablet. The 24-flavor herbal tea effervescent tablet comprises, by mass parts, 8 to 10 parts of 24-flavor herbal tea extract dry powder, 8 to 12 parts of mannitol, 12 to 15 parts of polyethylene glycol 6000, 20 to 25 parts of sodium bicarbonate, 8 to 12 parts of citric acid, 15 to 20 parts of sweetening agent and 8 to 12 parts of mint powdered flavor. The invention further discloses a method for preparing the 24-flavor herbal tea effervescent tablet. According to the 24-flavor herbal tea effervescent tablet, conventional herbal tea is made into the effervescent tablet, the effervescent tablet is convenient to produce and carry, can be used instantly after being brewed and is suitable for all ages, the problems of time consumption and complexity of the conventional herbal tea in the using process are solved, and the utility value of the herbal tea is improved greatly. The 24-flavor herbal tea effervescent tablet improves the preventive effect on the fatty liver.

Description

A kind of 24 taste cold tea effervescent tablets and preparation method thereof
Technical field
The invention belongs to cold tea processing technique field, be specifically related to a kind of 24 taste cold tea effervescent tablets, the invention still further relates to a kind of preparation method of 24 taste cold tea effervescent tablets.
Background technology
24 taste cold teas are a kind of folks of china Chinese traditional herbs, one of cold tea that Cantonese often drinks.This cold tea has clearing heat and removing internal wetness effect, and to control the card of affection of exogenous wind-heat, heating laryngalgia, also have comparatively act on too much stay up late for a long time discomfort that causes of throat, especially applicable summer drinks.
At present, use for 24 taste cold teas generally still rests on traditional cold tea and decocts, use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of 24 taste cold teas clearly is obviously reduced simultaneously, greatly hinders the promotion and application of 24 taste cold teas.Therefore, at present in the urgent need to providing a kind of 24 taste cold tea health drinks of conveniently drinking, to adapt to the demand of consumers in general, the quality of life of people is significantly promoted.
Effervescent tablet is a kind of tablet containing gas-producing disintegrant.The mixture of so-called gas-producing disintegrant normally organic acid and sodium carbonate, sodium acid carbonate (sodium bicarbonate); The dry moisture-free of effervescent tablet itself, two kinds of materials in gas-producing disintegrant are unionized can not react; But after effervescent tablet puts into water, two kinds of material generation acid-base reactions, produce great amount of carbon dioxide, make the rapid disintegration of tablet and thawing, and the bubble that disintegration sometimes produces also can make tablet roll up and down in water, accelerates its disintegration and thawing.The carbon dioxide produced during disintegration of tablet is partially dissolved in drinking-water, has the aesthetic feeling as carbonated drink when drinking-water is drunk in entrance.At present, effervescent tablet is at home and abroad widely used, and common are oral effervescent tablet, vagina effervescence; Have also appeared Traditional Chinese medicine foot-bath effervescent tablet etc. in recent years.
There is no 24 taste cold tea effervescent tablets at present, but the 24 taste cold tea effervescent tablets adopting the preparation method of conventional effervescent tablet to prepare exist that disintegration is slow, active principle is difficult to the problem that is dissolved out.
Summary of the invention
The object of this invention is to provide a kind of 24 taste cold tea effervescent tablets, solve the 24 taste cold teas existed in prior art and have that disintegration is slow, active principle is difficult to be dissolved out problem.
Another object of the present invention is to provide a kind of preparation method of 24 taste cold tea effervescent tablets.
First technical scheme of the present invention is, a kind of 24 taste cold tea effervescent tablets, comprise following component according to mass parts: 24 8 parts-10 parts, taste cold tea extract dry powder, 8 parts-12 parts, sweet mellow wine, Macrogol 6000 12 parts-15 parts, sodium acid carbonate 20 parts-25 parts, citric acid 8 parts-12 parts, sweetener 15 parts-20 parts, peppermint powdered flavor 8 parts-12 parts.
Further, 24 taste cold tea extract dry powder comprise following component according to mass parts: winter folium mori 5 parts-8 parts, honeysuckle stem 5 parts-8 parts, beggar-ticks 5 parts-8 parts, cordate houttuynia 24 parts-28 parts, achyranthes aspera 24 parts-28 parts, loguat leaf 24 parts-28 parts, sweet 24 parts-28 parts of the five fingers, LUBIANJU 12 parts-15 parts, blank sheet of paper fans 12 parts-15 parts, 12 parts-15 parts, Jinsha rattan, Ivy Tree Bark 12 parts-15 parts, field base king 12 parts-15 parts, Magnoliaceae 10 parts-15 parts, bitter 10 parts-15 parts of three bifurcations, desmodium 10 parts-15 parts, lophatherum gracile 10 parts-15 parts, emblic 28 parts-32 parts, Flos Ilicis Asprellae sheet 28 parts-32 parts, shortstyle cratoxylum leaf root or bark 28 parts-32 parts, wood Huan sheet 5 parts-8 parts, screwtree root 5 parts-8 parts, desmodium triquetrum 28 parts-32 parts, God in charge of the Earth's English 5 parts-8 parts, Chinese knotweed 28 parts-32 parts.
Second technical scheme of the present invention, a kind of preparation method of 24 taste cold tea effervescent tablets, comprises the following steps:
Step 1, preparation 24 taste cold tea dry powder;
Step 2, weighing, weigh following component according to weight portion: 24 8 parts-10 parts, taste cold tea extract dry powder, 8 parts-12 parts, sweet mellow wine, Macrogol 6000 12 parts-15 parts, sodium acid carbonate 20 parts-25 parts, citric acid 8 parts-12 parts, sweetener 15 parts-20 parts, peppermint powdered flavor 8 parts-12 parts;
Step 3, by 24 taste cold tea extract dry powder, sweet mellow wine, Macrogol 6000, sodium acid carbonate, citric acid, sweetener, peppermint powdered flavor respectively porphyrize, cross 50 mesh sieves and make it mix;
Step 4, the mixed powder prepared in step 3 to be granulated, flatten, prepare 24 taste cold tea effervescent tablets.
Further, prepare 24 taste cold tea dry powder in step 1 to be specially:
Step 1.1, weigh: weigh following component according to mass parts: winter folium mori 5 parts-8 parts, honeysuckle stem 5 parts-8 parts, beggar-ticks 5 parts-8 parts, cordate houttuynia 24 parts-28 parts, achyranthes aspera 24 parts-28 parts, loguat leaf 24 parts-28 parts, sweet 24 parts-28 parts of the five fingers, LUBIANJU 12 parts-15 parts, blank sheet of paper fans 12 parts-15 parts, 12 parts-15 parts, Jinsha rattan, Ivy Tree Bark 12 parts-15 parts, field base king 12 parts-15 parts, Magnoliaceae 10 parts-15 parts, bitter 10 parts-15 parts of three bifurcations, desmodium 10 parts-15 parts, lophatherum gracile 10 parts-15 parts, emblic 28 parts-32 parts, Flos Ilicis Asprellae sheet 28 parts-32 parts, shortstyle cratoxylum leaf root or bark 28 parts-32 parts, wood Huan sheet 5 parts-8 parts, screwtree root 5 parts-8 parts, desmodium triquetrum 28 parts-32 parts, God in charge of the Earth's English 5 parts-8 parts, Chinese knotweed 28 parts-32 parts,
Step 1.2, above-mentioned load weighted each component is ground into tea powder respectively, crosses 50 mesh sieves, through 6-12kGy 60co-gamma-ray irradiation, by 24 kinds of tea powder mixing, prepares 24 taste cold tea mixed powders;
Step 1.3, extract and filter: in extractor, add the water being equivalent to 24 taste cold tea mixed powder 3-5 and doubly weighing, normal temperature is heated to 60-75 DEG C, adds 24 taste cold tea mixed powders, stirring and extract 8-12 minute, 180-220 mesh filter screen and filter;
Step 1.4, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa-20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, is 24 taste cold tea extract dry powder.
Further, spraying dry pressure: 55Mpa, feeding temperature: 75 DEG C, EAT: 205 DEG C, leaving air temp: 85 DEG C; Rotating speed is 25000r/min-30000r/min.
Further, the grain made parameter in step 4 is: aperture is 3.0, and compression ratio is 1:3, and temperature is 65 DEG C-68 DEG C, and pressure is 0.3MP-0.5MP.
The invention has the beneficial effects as follows: 1, the effective component in above-mentioned 24 components can extract by the present invention fully.
2, disintegration time limited of 24 taste cold tea effervescent tablets that this formula and preparation method obtain can reach 112s, solve the slow difficult problem of Effervescent tablet disintegration, by the screening of the proportioning to 24 taste cold teas and the screening to gas-producing disintegrant and lubricant etc., 24 taste cold tea effervescent tablets of the present invention are made to obtain best effervesce effect.
3, the present invention makes effervescent tablet traditional herb tea, be convenient to produce and carry, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of cold tea greatly.
4, the preventive effect of effervescent tablet of the present invention to fatty liver is improved.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in detail.
The invention provides a kind of 24 taste cold tea effervescent tablets, comprise following component according to mass parts: 24 8 parts-10 parts, taste cold tea extract dry powder, 8 parts-12 parts, sweet mellow wine, Macrogol 6000 12 parts-15 parts, sodium acid carbonate 20 parts-25 parts, citric acid 8 parts-12 parts, sweetener 15 parts-20 parts, peppermint powdered flavor 8 parts-12 parts.
Wherein, 24 taste cold tea extract dry powder comprise following component according to mass parts: winter folium mori 5 parts-8 parts, honeysuckle stem 5 parts-8 parts, beggar-ticks 5 parts-8 parts, cordate houttuynia 24 parts-28 parts, achyranthes aspera 24 parts-28 parts, loguat leaf 24 parts-28 parts, sweet 24 parts-28 parts of the five fingers, LUBIANJU 12 parts-15 parts, blank sheet of paper fans 12 parts-15 parts, 12 parts-15 parts, Jinsha rattan, Ivy Tree Bark 12 parts-15 parts, field base king 12 parts-15 parts, Magnoliaceae 10 parts-15 parts, bitter 10 parts-15 parts of three bifurcations, desmodium 10 parts-15 parts, lophatherum gracile 10 parts-15 parts, emblic 28 parts-32 parts, Flos Ilicis Asprellae sheet 28 parts-32 parts, shortstyle cratoxylum leaf root or bark 28 parts-32 parts, wood Huan sheet 5 parts-8 parts, screwtree root 5 parts-8 parts, desmodium triquetrum 28 parts-32 parts, God in charge of the Earth's English 5 parts-8 parts, Chinese knotweed 28 parts-32 parts.
The present invention also provides a kind of preparation method of 24 taste cold tea effervescent tablets, comprises the following steps:
Step 1, preparation 24 taste cold tea dry powder:
Step 1.1, weigh: weigh following component according to mass parts: winter folium mori 5 parts-8 parts, honeysuckle stem 5 parts-8 parts, beggar-ticks 5 parts-8 parts, cordate houttuynia 24 parts-28 parts, achyranthes aspera 24 parts-28 parts, loguat leaf 24 parts-28 parts, sweet 24 parts-28 parts of the five fingers, LUBIANJU 12 parts-15 parts, blank sheet of paper fans 12 parts-15 parts, 12 parts-15 parts, Jinsha rattan, Ivy Tree Bark 12 parts-15 parts, field base king 12 parts-15 parts, Magnoliaceae 10 parts-15 parts, bitter 10 parts-15 parts of three bifurcations, desmodium 10 parts-15 parts, lophatherum gracile 10 parts-15 parts, emblic 28 parts-32 parts, Flos Ilicis Asprellae sheet 28 parts-32 parts, shortstyle cratoxylum leaf root or bark 28 parts-32 parts, wood Huan sheet 5 parts-8 parts, screwtree root 5 parts-8 parts, desmodium triquetrum 28 parts-32 parts, God in charge of the Earth's English 5 parts-8 parts, Chinese knotweed 28 parts-32 parts,
Step 1.2, above-mentioned load weighted each component is ground into tea powder respectively, crosses 50 mesh sieves, through 6-12kGy 60co-gamma-ray irradiation, by 24 kinds of tea powder mixing, prepares 24 taste cold tea mixed powders;
Step 1.3, extract and filter: in extractor, add the water being equivalent to 24 taste cold tea mixed powder 3-5 and doubly weighing, normal temperature is heated to 60-75 DEG C, adds 24 taste cold tea mixed powders, stirring and extract 8-12 minute, 180-220 mesh filter screen and filter;
Step 1.4, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa-20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, is 24 taste cold tea extract dry powder; Spraying dry pressure: 55Mpa, feeding temperature: 75 DEG C, EAT: 205 DEG C, leaving air temp: 85 DEG C; Rotating speed is 25000r/min-30000r/min;
Step 2, weighing, weigh following component according to weight portion: 24 8 parts-10 parts, taste cold tea extract dry powder, 8 parts-12 parts, sweet mellow wine, Macrogol 6000 12 parts-15 parts, sodium acid carbonate 20 parts-25 parts, citric acid 8 parts-12 parts, sweetener 15 parts-20 parts, peppermint powdered flavor 8 parts-12 parts;
Step 3, by sweet mellow wine, Macrogol 6000, sodium acid carbonate, citric acid, sweetener, peppermint powdered flavor respectively porphyrize, cross 50 mesh sieves and make it mix;
Step 4, the mixed powder prepared in step 3 to be granulated, flatten, prepare 24 taste cold tea effervescent tablets; Grain made parameter is aperture is 3.0, and compression ratio is 1:3, and temperature is 65 DEG C-68 DEG C, and pressure is 0.3MP-0.5MP.
Embodiment 1
A kind of preparation method of 24 taste cold tea effervescent tablets, comprise the following steps: weigh following component according to mass parts: winter folium mori 6 parts, honeysuckle stem 6 parts, beggar-ticks 6 parts, cordate houttuynia 26 parts, achyranthes aspera 26 parts, loguat leaf 26 parts, sweet 26 parts of the five fingers, LUBIANJU 14 parts, blank sheet of paper fans 14 parts, 14 parts, Jinsha rattan, Ivy Tree Bark 14 parts, field base king 14 parts, Magnoliaceae 13 parts, bitter 13 parts of three bifurcations, desmodium 13 parts, lophatherum gracile 12 parts, emblic 30 parts, Flos Ilicis Asprellae sheet 30 parts, shortstyle cratoxylum leaf root or bark 30 parts, wood Huan sheet 7 parts, screwtree root 7 parts, desmodium triquetrum 30 parts, God in charge of the Earth's English 7 parts, Chinese knotweed 30 parts, above-mentioned load weighted each component is ground into tea powder respectively, crosses 50 mesh sieves, through 9kGy 60co-gamma-ray irradiation, by 24 kinds of tea powder mixing, prepares 24 taste cold tea mixed powders, in extractor, add the water being equivalent to 24 taste cold tea mixed powders, 4 times of weights, normal temperature is heated to 70 DEG C, adds 24 taste cold tea mixed powders, stirs extraction 10 minutes 200 mesh filter screens and filters, filtrate is heated to 70 DEG C, be decompressed to 5KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, is 24 taste cold tea extract dry powder, spraying dry pressure: 55Mpa, feeding temperature: 75 DEG C, EAT: 205 DEG C, leaving air temp: 85 DEG C, rotating speed is 28000r/min, following component is weighed: 24 9 parts, taste cold tea extract dry powder, 10 parts, sweet mellow wine, Macrogol 6000 13 parts, sodium acid carbonate 22 parts, citric acid 10 parts, sweetener 18 parts, peppermint powdered flavor 10 parts according to weight portion, by 24 taste cold tea extract dry powder, sweet mellow wine, Macrogol 6000, sodium acid carbonate, citric acid, sweetener, peppermint powdered flavor porphyrize respectively, cross 50 mesh sieves and make it mix, the mixed powder prepared is granulated, flattens, prepare 24 taste cold tea effervescent tablets, grain made parameter is aperture is 3.0, and compression ratio is 1:3, and temperature is 66 DEG C, and pressure is 0.4MP.
Embodiment 2
A kind of preparation method of 24 taste cold tea effervescent tablets, comprise the following steps: weigh following component according to mass parts: winter folium mori 5 parts, honeysuckle stem 5 parts, beggar-ticks 5 parts, cordate houttuynia 28 parts, achyranthes aspera 28 parts, loguat leaf 28 parts, sweet 28 parts of the five fingers, LUBIANJU 12 parts, blank sheet of paper fans 12 parts, 12 parts, Jinsha rattan, Ivy Tree Bark 12 parts, field base king 12 parts, Magnoliaceae 15 parts, bitter 15 parts of three bifurcations, desmodium 15 parts, lophatherum gracile 15 parts, emblic 28 parts, Flos Ilicis Asprellae sheet 28 parts, shortstyle cratoxylum leaf root or bark 28 parts, wood Huan sheet 8 parts, screwtree root 8 parts, desmodium triquetrum 28 parts, God in charge of the Earth's English 8 parts, Chinese knotweed 28 parts, above-mentioned load weighted each component is ground into tea powder respectively, crosses 50 mesh sieves, through 6kGy 60co-gamma-ray irradiation, by 24 kinds of tea powder mixing, prepares 24 taste cold tea mixed powders, in extractor, add the water being equivalent to 24 taste cold tea mixed powders, 3 times of weights, normal temperature is heated to 60 DEG C, adds 24 taste cold tea mixed powders, stirs extraction 8 minutes, and 180 mesh filter screens filter, filtrate is heated to 60 DEG C, be decompressed to-15KPaKPa when being concentrated into 1/4 of total filtrate weight, spraying dry makes dry powder, is 24 taste cold tea extract dry powder, spraying dry pressure: 55Mpa, feeding temperature: 75 DEG C, EAT: 205 DEG C, leaving air temp: 85 DEG C, rotating speed is 25000r/min, following component is weighed: 24 8 parts, taste cold tea extract dry powder, 12 parts, sweet mellow wine, Macrogol 6000 12 parts, sodium acid carbonate 25 parts, citric acid 8 parts, sweetener 20 parts, peppermint powdered flavor 8 parts according to weight portion, by 24 taste cold tea extract dry powder, sweet mellow wine, Macrogol 6000, sodium acid carbonate, citric acid, sweetener, peppermint powdered flavor porphyrize respectively, cross 50 mesh sieves and make it mix, the mixed powder prepared is granulated, flattens, prepare 24 taste cold tea effervescent tablets, grain made parameter is aperture is 3.0, and compression ratio is 1:3, and temperature is 65 DEG C, and pressure is 0.3MP.
Embodiment 3
A preparation method for 24 taste cold tea effervescent tablets, comprises the following steps: weigh following component according to mass parts: winter folium mori 8 parts, honeysuckle stem 8 parts, beggar-ticks 8 parts, cordate houttuynia 24 parts, achyranthes aspera 24 parts, loguat leaf 24 parts, sweet 24 parts of the five fingers, LUBIANJU 15 parts, blank sheet of paper fan 15 parts, 15 parts, Jinsha rattan, Ivy Tree Bark 15 parts, field base king 15 parts, Magnoliaceae 10 parts, bitter 10 parts of three bifurcations, desmodium 10 parts, lophatherum gracile 10 parts, emblic 32 parts, Flos Ilicis Asprellae sheet 32 parts, shortstyle cratoxylum leaf root or bark 32 parts, wooden Huan sheet 5 parts, screwtree root 5 parts, desmodium triquetrum 32 parts, God in charge of the Earth's English 5 parts, 32 parts; Above-mentioned load weighted each component is ground into tea powder respectively, crosses 50 mesh sieves, through 12kGy 60co-gamma-ray irradiation, by 24 kinds of tea powder mixing, prepares 24 taste cold tea mixed powders; In extractor, add the water being equivalent to 24 taste cold tea mixed powder 3-5 and doubly weighing, normal temperature is heated to 75 DEG C, adds 24 taste cold tea mixed powders, stirs extraction 12 minutes, and 220 mesh filter screens filter; Filtrate is heated to 80 DEG C, be decompressed to 20KPa when being concentrated into 1/3 of total filtrate weight, spraying dry makes dry powder, is 24 taste cold tea extract dry powder; Spraying dry pressure: 55Mpa, feeding temperature: 75 DEG C, EAT: 205 DEG C, leaving air temp: 85 DEG C; Rotating speed is 25000r/min-30000r/min; Following component is weighed: 24 10 parts, taste cold tea extract dry powder, 8 parts, sweet mellow wine, Macrogol 6000 15 parts, sodium acid carbonate 20 parts, citric acid 12 parts, sweetener 15 parts, peppermint powdered flavor 12 parts according to weight portion; By 24 taste cold tea extract dry powder, sweet mellow wine, Macrogol 6000, sodium acid carbonate, citric acid, sweetener, peppermint powdered flavor porphyrize respectively, cross 50 mesh sieves and make it mix; The mixed powder prepared is granulated, flattens, prepare 24 taste cold tea effervescent tablets; Grain made parameter is aperture is 3.0, and compression ratio is 1:3, and temperature is 68 DEG C, and pressure is 0.5MP.
Comparative example:
The effervescent tablet that common process prepares.
Below in conjunction with disintegration time limited, subjective appreciation, hardness, outward appearance, drug effect evaluate beneficial effect of the present invention:
1, disintegration time detects
In 250mL beaker, add the water of 200mL and water temperature is controlled then add 1 effervescent tablet 15 ~ 25.When gas around tablet or fragment stops overflowing, tablet should be dissolved or dispersed in water, left without the particle assembled.No longer include gas to solution to overflow and time difference T (s) of dissolving is the disintegration time of effervescent tablet, experimental result part table 1 from adding effervescent tablet.
2, subjective appreciation
Scoring: thrown by effervescent tablet in people 300mL water, adopt " double-blind study " to carry out sour-sweet degree organoleptic examination scoring, scoring number is 20 people, averages, full marks 100 points.This accounts for 40% of total score value.Disintegration time is marked, and detects disintegration time by 1, and the shortest for disintegration time in test is decided to be full marks 100 points, and disintegration time often increases 5s and subtracts 1 point.This scoring accounts for total score value 60%, and outward appearance scoring accounts for 20%, mouthfeel 20%, experimental result part table 1.
3, hardness (Monsanto durometer method)
Be placed on by tablet between two pressing plates, diametrically pressurization slowly, the pressure just during fragmentation is the hardness of this effervescent tablet, and unit is N, experimental result part table 1.
4, the test of pesticide effectiveness
4.1, the routine patient of clinical observation 60, treatment group 30 example, control group 30 example.Whole case history all meets case selection standard, man 36 example, female 24 example, age 35-48 year, the course of disease is the shortest 2 days, the longest 2 weeks, takes 24 taste cold tea effervescent tablet one week.
Diagnosis basis: the standard that disconnected standard is demonstrate,proved based on anemopyretic cold relevant in " disease of tcm Standardization of diagnosis and curative effect ", 1. heating, micro-aversion to wind and cold, nasal obstruction runny nose, sneeze, headache, general malaise.2. pink tongue or limit point red, platform book is yellow, superficial and rapid pulse.3. unusual weather conditions or daily life cause accidentally, sudden onset.
Symptom and sign ranking criterion: according to correlation intergal standard in " traditional Chinese medical science Clinical Researches of New Drugs guideline ", the disappearance of headache, bodily pain, runny nose, pharyngalgia, congestion of throat, cough, slight, moderate, severe long-pending 0,1,2,3 point respectively.
Inclusive criteria: meet traditional Chinese medical science anemopyretic cold card diagnostic criteria, body temperature is no more than 39 DEG C of persons, and the course of disease is person within 48h, and the age is between 18 ~ 65 years old.
Excluded cases standard: used medicine person as antibiotic, hormone or other cold medicines person or the person that do not bring down a fever; Merge other primary disease persons of lung, as pulmonary tuberculosis, lung swelling and pain person; Merge serious cardiovascular, liver, kidney and disease of hematopoietic system person; Age is under-18s or over-65s person or be the gestational period, women breast-feeding their children, and physique allergy sufferers.
Control group: comparative example effervescent tablet, 3 times/d, 7d were 1 course for the treatment of.
Criterion of therapeutical effect: cardinal symptom sign curative effect determinate standard more than temperature decline 0.5C is onset, dropping to 37.4C is that temperature recovery is normal.Other symptom and sign integrations reduce by 1 and are divided into onset, and 0 is divided into disappearance.Comprehensive therapeutic effect criterion is fully recovered: within treatment 3d, temperature recovery is normal, and sings and symptoms all disappears, or symptom, somatic feature score decline more than 90% person; Effective: within treatment 3d, body temperature is normal, and most of sings and symptoms disappears, or symptom, somatic feature score decline more than 75% person; Effective: treatment 3d within body temperature reduce than before, cardinal symptom and sign partial disappearance, or symptom, somatic feature score decline more than 50% person; Invalid: within treatment 3d, body temperature does not fall or raises, cardinal symptom and sign are without improvement or improve <50%.Treatment results: in table 2.
Contrast with embodiments of the invention 1-5 and comparative example, draw the following conclusions.
Table 1 comparing result
Disintegration time limited (s) Sensory evaluation scores (dividing) Hardness (N)
Embodiment 1 112s 100 60N
Embodiment 2 139s 96 68N
Embodiment 3 146s 85 69N
Comparative example 490s 45 62N
The observation of curative effect of this effervescent tablet of table 2 treatment anemopyretic cold patient
Group Total number of cases Recovery from illness Effective Effectively Invalid Total effective rate
Embodiment 1 30 25 2 2 1 96.7%
Embodiment 2 30 21 2 2 3 90%
Embodiment 3 30 16 6 4 4 86.7%
Comparative example 30 6 4 5 15 50%
As shown in Table 2, illustrate that the effective component ratio in effervescent tablet of the present invention is easier to extract, effervescent tablet treatment anemopyretic cold effect of the present invention is higher than existing 24 taste cold tea effervescent tablets.
4.2, effervescent tablet of the present invention is to the research of Rats adiposis hepatica improvement result
Method: healthy male SD rat, is divided into 3 groups at random: Normal group, 24 taste cold tea effervescent tablet high dose group, 24 taste cold tea effervescent tablet low dose group, often organizes 6.Normal group feeding formula feed, contain 1% orotic acid in model group feed with induced synthesis fatty liver, other tested group is added a certain amount of different types of effervescent tablet on this basis respectively, and feed upgrades and measures food ration every day, the next day survey a body weight, feed 14d continuously.Rat is after last feeding, and water 12h is can't help in fasting, and etherization pneumoretroperitoneum sustainer is got whole blood and put to death.Get liver, kidney, interior fat weigh.Extract with Folch method that it is always fatty, kit measurement TC, TG content.
Conclusion: as shown in table 3, the horizontal compared with normal group of model group rats liver TC, TG improves 2.4 times and 3.4 times respectively, shows fatty liver modeling success.Each experimental group all significantly can reduce liver TC level, 24 taste cold tea effervescent tablet various dose groups all have certain inhibitory action to the accumulation of liver TG, but there is significant difference, reduction amplitude is respectively 48% (P<0.05) and 33% (P<0.05), and 24 taste cold tea effervescent tablet high dose group reduce best results.
Table 3 effervescent tablet of the present invention is on the impact of Hepaticlipid concentration
Note: #p<0.05, compares with normal group; *p<0.05, compares with model group
Notes: #P<0.05,comparedwithnormalgroup; *P<0.05,comparedwithmodelgroup
1., according to the inventive method, the application manually produces 150 batches of 24 taste cold tea effervescent tablets altogether, product percent of pass 100%;
2. according to national standard, the 24 taste cold tea effervescent tablet terms of validity 24 months, the applicant's reserved sample observing to 36 month, every quality index has not yet to see obvious change;
3. embodiment 1-3 and comparative example illustrate and the invention solves the slow difficult problem of Effervescent tablet disintegration, by the screening of the proportioning to 24 taste cold teas and the screening to gas-producing disintegrant and lubricant etc., 24 taste cold tea effervescent tablets of the present invention are made to obtain best effervesce effect;
4. can be found out by above-mentioned result of the test, it is fast that 24 taste cold tea effervescent tablets of the present invention have disintegration compared with prior art products, and good stability, the advantages such as weight differential is little, can provide more stable, effective, safe product for patient.
5. the 24 taste cold tea effervescent tablets prepared, smooth appearance, uniform color, sweet and sour taste, this stable process conditions of experiment results proved is feasible.

Claims (6)

1. a taste cold tea effervescent tablet, it is characterized in that, comprise following component according to mass parts: 24 8 parts-10 parts, taste cold tea extract dry powder, 8 parts-12 parts, sweet mellow wine, Macrogol 6000 12 parts-15 parts, sodium acid carbonate 20 parts-25 parts, citric acid 8 parts-12 parts, sweetener 15 parts-20 parts, peppermint powdered flavor 8 parts-12 parts.
2. 24 taste cold tea effervescent tablets according to claim 1, it is characterized in that, described 24 taste cold tea extract dry powder comprise following component according to mass parts: winter folium mori 5 parts-8 parts, honeysuckle stem 5 parts-8 parts, beggar-ticks 5 parts-8 parts, cordate houttuynia 24 parts-28 parts, achyranthes aspera 24 parts-28 parts, loguat leaf 24 parts-28 parts, sweet 24 parts-28 parts of the five fingers, LUBIANJU 12 parts-15 parts, blank sheet of paper fans 12 parts-15 parts, 12 parts-15 parts, Jinsha rattan, Ivy Tree Bark 12 parts-15 parts, field base king 12 parts-15 parts, Magnoliaceae 10 parts-15 parts, bitter 10 parts-15 parts of three bifurcations, desmodium 10 parts-15 parts, lophatherum gracile 10 parts-15 parts, emblic 28 parts-32 parts, Flos Ilicis Asprellae sheet 28 parts-32 parts, shortstyle cratoxylum leaf root or bark 28 parts-32 parts, wood Huan sheet 5 parts-8 parts, screwtree root 5 parts-8 parts, desmodium triquetrum 28 parts-32 parts, God in charge of the Earth's English 5 parts-8 parts, Chinese knotweed 28 parts-32 parts.
3. a preparation method for 24 taste cold tea effervescent tablets, is characterized in that, comprise the following steps:
Step 1, preparation 24 taste cold tea dry powder;
Step 2, weighing, weigh following component according to weight portion: 24 8 parts-10 parts, taste cold tea extract dry powder, 8 parts-12 parts, sweet mellow wine, Macrogol 6000 12 parts-15 parts, sodium acid carbonate 20 parts-25 parts, citric acid 8 parts-12 parts, sweetener 15 parts-20 parts, peppermint powdered flavor 8 parts-12 parts;
Step 3, by 24 taste cold tea extract dry powder, sweet mellow wine, Macrogol 6000, sodium acid carbonate, citric acid, sweetener, peppermint powdered flavor respectively porphyrize, cross 50 mesh sieves and make it mix;
Step 4, the mixed powder prepared in step 3 to be granulated, flatten, prepare 24 taste cold tea effervescent tablets.
4. the preparation method of 24 taste cold tea effervescent tablets according to claim 3, is characterized in that, prepares 24 taste cold tea dry powder and be specially in described step 1:
Step 1.1, weigh: weigh following component according to mass parts: winter folium mori 5 parts-8 parts, honeysuckle stem 5 parts-8 parts, beggar-ticks 5 parts-8 parts, cordate houttuynia 24 parts-28 parts, achyranthes aspera 24 parts-28 parts, loguat leaf 24 parts-28 parts, sweet 24 parts-28 parts of the five fingers, LUBIANJU 12 parts-15 parts, blank sheet of paper fans 12 parts-15 parts, 12 parts-15 parts, Jinsha rattan, Ivy Tree Bark 12 parts-15 parts, field base king 12 parts-15 parts, Magnoliaceae 10 parts-15 parts, bitter 10 parts-15 parts of three bifurcations, desmodium 10 parts-15 parts, lophatherum gracile 10 parts-15 parts, emblic 28 parts-32 parts, Flos Ilicis Asprellae sheet 28 parts-32 parts, shortstyle cratoxylum leaf root or bark 28 parts-32 parts, wood Huan sheet 5 parts-8 parts, screwtree root 5 parts-8 parts, desmodium triquetrum 28 parts-32 parts, God in charge of the Earth's English 5 parts-8 parts, Chinese knotweed 28 parts-32 parts,
Step 1.2, above-mentioned load weighted each component is ground into tea powder respectively, crosses 50 mesh sieves, through 6-12kGy 60co-gamma-ray irradiation, by 24 kinds of tea powder mixing, prepares 24 taste cold tea mixed powders;
Step 1.3, extract and filter: in extractor, add the water being equivalent to 24 taste cold tea mixed powder 3-5 and doubly weighing, normal temperature is heated to 60-75 DEG C, adds 24 taste cold tea mixed powders, stirring and extract 8-12 minute, 180-220 mesh filter screen and filter;
Step 1.4, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa-20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, is 24 taste cold tea extract dry powder.
5. the preparation method of 24 taste cold tea effervescent tablets according to claim 4, is characterized in that, described spraying dry pressure: 55Mpa, feeding temperature: 75 DEG C, EAT: 205 DEG C, leaving air temp: 85 DEG C; Rotating speed is 25000r/min-30000r/min.
6. the preparation method of 24 taste cold tea effervescent tablets according to claim 4, it is characterized in that, the grain made parameter in described step 4 is: aperture is 3.0, and compression ratio is 1:3, and temperature is 65 DEG C-68 DEG C, and pressure is 0.3MP-0.5MP.
CN201510903908.8A 2015-12-08 2015-12-08 24-flavor herbal tea effervescent tablet and preparation method thereof Pending CN105432886A (en)

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CN108576544A (en) * 2018-04-11 2018-09-28 云南中医学院 Yunnan olive honeysuckle effervescent tablet and preparation method thereof
CN113101310A (en) * 2021-03-26 2021-07-13 香港科技大学 Medicine for preventing and/or treating coronavirus infection and preparation method thereof

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