CN105560317A - Effervescent tablets containing frangipani tea, and preparation method of effervescent tablets - Google Patents
Effervescent tablets containing frangipani tea, and preparation method of effervescent tablets Download PDFInfo
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- CN105560317A CN105560317A CN201510903694.4A CN201510903694A CN105560317A CN 105560317 A CN105560317 A CN 105560317A CN 201510903694 A CN201510903694 A CN 201510903694A CN 105560317 A CN105560317 A CN 105560317A
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- flos plumeriae
- plumeriae acutifoliae
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- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000007938 effervescent tablet Substances 0.000 title abstract description 27
- 244000071969 Plumeria obtusa Species 0.000 title abstract 4
- 235000013087 Plumeria rubra Nutrition 0.000 title abstract 4
- 244000269722 Thea sinensis Species 0.000 title abstract 4
- 239000000843 powder Substances 0.000 claims abstract description 49
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims abstract description 18
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 12
- 229930195725 Mannitol Natural products 0.000 claims abstract description 12
- 239000000594 mannitol Substances 0.000 claims abstract description 12
- 235000010355 mannitol Nutrition 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 10
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims abstract description 7
- 241001122767 Theaceae Species 0.000 claims description 105
- 241000628997 Flos Species 0.000 claims description 76
- 230000001476 alcoholic effect Effects 0.000 claims description 30
- 238000000605 extraction Methods 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 21
- 238000005303 weighing Methods 0.000 claims description 21
- 239000006228 supernatant Substances 0.000 claims description 20
- 239000000706 filtrate Substances 0.000 claims description 16
- 238000005507 spraying Methods 0.000 claims description 16
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 239000000796 flavoring agent Substances 0.000 claims description 11
- 235000019634 flavors Nutrition 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 238000007598 dipping method Methods 0.000 claims description 10
- 238000002203 pretreatment Methods 0.000 claims description 10
- 230000003068 static effect Effects 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 239000012141 concentrate Substances 0.000 claims description 8
- 238000001694 spray drying Methods 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 7
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 7
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims description 6
- 238000007906 compression Methods 0.000 claims description 6
- 230000006835 compression Effects 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000011812 mixed powder Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 abstract description 10
- 208000004930 Fatty Liver Diseases 0.000 abstract description 2
- 206010019708 Hepatic steatosis Diseases 0.000 abstract description 2
- 208000010706 fatty liver disease Diseases 0.000 abstract description 2
- 231100000240 steatosis hepatitis Toxicity 0.000 abstract description 2
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 235000013616 tea Nutrition 0.000 description 82
- 239000003826 tablet Substances 0.000 description 33
- 208000024891 symptom Diseases 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000007884 disintegrant Substances 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 230000036760 body temperature Effects 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 235000015092 herbal tea Nutrition 0.000 description 4
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 3
- 230000008034 disappearance Effects 0.000 description 3
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- 239000001569 carbon dioxide Substances 0.000 description 2
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- 238000003745 diagnosis Methods 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
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- SBNFWQZLDJGRLK-UHFFFAOYSA-N phenothrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 SBNFWQZLDJGRLK-UHFFFAOYSA-N 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
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- 206010037660 Pyrexia Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000010669 acid-base reaction Methods 0.000 description 1
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- 239000002221 antipyretic Substances 0.000 description 1
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- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
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- 210000002784 stomach Anatomy 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
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Abstract
The invention discloses effervescent tablets containing frangipani tea. The effervescent tablets are prepared from the following components in parts by weight: 1-4 parts of dry frangipani tea extract powder, 5-8 parts of extract of radix angelicae sinensis produced in Min county, 12-16 parts of mannitol, 12-16 parts of polyethylene glycol 6000, 25-35 parts of sodium bicarbonate, 1-2 parts of citric acid, 2-4 parts of sweetening agent and 2-4 parts of mint powder essence. The invention also discloses a preparation method of the effervescent tablets containing the frangipani tea. After the preparation method is adopted, the medicinal composition in dried tangerine peel can be fully extracted; the effect of preventing fatty liver of the effervescent tablets can be improved.
Description
Technical field
The invention belongs to Chinese herbal medicine preparation technology field, be specifically related to a kind of Flos Plumeriae Acutifoliae effervescent tea tablet, the invention still further relates to a kind of preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet.
Background technology
Often the Flos Plumeriae Acutifoliae of white is dried in In Guangdong Province and make antipyretic beverage, be popular; Cool in nature, sweet in the mouth, light; Return large intestine, stomach warp, there is effect of lung moistening removing toxic substances, clearing heat and expelling damp, laxation.Saying it as " south of the Five Ridges gather medicinal herbs record " can " controls damp-heat diarrhea, pain in the abdomen tongue weight, again can lung moistening removing toxic substances ".Though Fructus Momordicae charantiae is bitter, bitterness is cool in nature, feels more cool and comfortable after eating during summer-heat day, has the effect of the appetizing that clears away heart-fire.
At present, the use for Flos Plumeriae Acutifoliae generally still rests on traditional herbal tea and decocts, and use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of Flos Plumeriae Acutifoliae is obviously reduced simultaneously, greatly hinders the promotion and application of Flos Plumeriae Acutifoliae.Therefore, at present in the urgent need to providing a kind of Flos Plumeriae Acutifoliae dosage form easy to use, to adapt to the demand of consumers in general, significantly promoted the quality of life of people.
Effervescent tablet is a kind of tablet containing gas-producing disintegrant.The mixture of so-called gas-producing disintegrant normally organic acid and sodium carbonate, sodium bicarbonate (sodium bicarbonate); The dry moisture-free of effervescent tablet itself, two kinds of materials in gas-producing disintegrant are unionized can not react; But after water put into by effervescent tablet, two kinds of material generation acid-base reactions, produce great amount of carbon dioxide, make the rapid disintegrate of tablet and thawing, and the bubble that disintegrate sometimes produces also can make tablet roll up and down in water, accelerates its disintegrate and thawing.The carbon dioxide produced during disintegration of tablet is partially dissolved in drinking-water, has the aesthetic feeling as soda pop when drinking-water is drunk in entrance.At present, effervescent tablet is at home and abroad widely used, and common are oral effervescent tablet, vagina effervescence; Have also appeared Traditional Chinese medicine foot-bath effervescent tablet etc. in recent years.
Egg scented tea is a kind of folks of china tradition beverage, one of herbal tea that Cantonese often drinks, use for egg scented tea generally still rests on traditional herbal tea and decocts, use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of egg scented tea is obviously reduced simultaneously, greatly hinder the promotion and application of egg scented tea.Have in current Flos Plumeriae Acutifoliae effervescent tea tablet that disintegrate is slow, active component in egg scented tea is difficult to the problem that is dissolved out.
Summary of the invention
The object of this invention is to provide a kind of Flos Plumeriae Acutifoliae effervescent tea tablet, solve that the disintegrate that exists in prior art is slow, composition and effectiveness in egg scented tea is difficult to the problem that is dissolved out.
Another object of the present invention is to provide the preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet.
First technical scheme of the present invention is, a kind of Flos Plumeriae Acutifoliae effervescent tea tablet, comprises following component according to mass parts: 1 ~ 4 part, Flos Plumeriae Acutifoliae tea extract dry powder, Min return extract 5 parts-8 parts, mannitol, polyethylene glycol 6000 12 parts-16 parts, sodium bicarbonate 25 parts-35 parts, citric acid 1 part-2 parts, sweeting agent 2 parts-4 parts, Herba Menthae powdered flavor 2 parts-4 parts.
Further, Flos Plumeriae Acutifoliae tea extract dry powder prepares in the following manner:
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 25-30kGy
60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 8-10 and doubly weighing, room temperature is heated to 75-90 DEG C, adds egg scented tea, stirring and extract 8-12 minute, 200-300 mesh filter screen and filter;
Step 1.3, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa--20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min-30000r/min.
Further, Min returns extract to prepare in the following manner:
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract.
Second technical scheme of the present invention is, a kind of preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet, comprises the following steps:
Step 1, prepare Flos Plumeriae Acutifoliae tea extract dry powder,
Step 2, preparation Min return extract,
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract;
Step 3, weighing: weigh following component according to mass parts: 1 ~ 4 part, Flos Plumeriae Acutifoliae tea extract dry powder, Min return extract 5 parts-8 parts, mannitol, polyethylene glycol 6000 12 parts-16 parts, sodium bicarbonate 25 parts-35 parts, citric acid 1 part-2 parts, sweeting agent 2 parts-4 parts, Herba Menthae powdered flavor 2 parts-4 parts;
Step 4, by load weighted Flos Plumeriae Acutifoliae tea decocting liquid, mannitol, polyethylene glycol 6000 (PEG6000), sodium bicarbonate, citric acid, sweeting agent, Herba Menthae powdered flavor respectively porphyrize, cross 50 mesh sieves and make its mix homogeneously;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare Flos Plumeriae Acutifoliae effervescent tea tablet.
Further, step 1) in Flos Plumeriae Acutifoliae tea extract dry powder prepare by the following method:
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 25-30kGy
60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 8-10 and doubly weighing, room temperature is heated to 75-90 DEG C, adds egg scented tea, stirring and extract 8-12 minute, 200-300 mesh filter screen and filter;
Step 1.3, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa--20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min-30000r/min.
Further, step 2) in Min return extract to prepare by the following method:
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract.
Further, grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C-78 DEG C, and pressure is 0.5MP-0.6MP.
The invention has the beneficial effects as follows: the disintegration of the Flos Plumeriae Acutifoliae effervescent tea tablet that this formula and preparation method obtain can reach 110s, solve the slow difficult problem of Effervescent tablet disintegration, screening by the proportioning to orange peel tea effervescent tablet and the screening to gas-producing disintegrant and lubricant etc., make orange peel tea effervescent tablet of the present invention obtain best effervescent effect.
Active ingredient in Pericarpium Citri Reticulatae can extract by the present invention fully; The preventive effect of fatty liver is improved.The present invention organically combines effervescent tablet preparation formulation and traditional herb tea, be convenient to produce and carry, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of herbal tea greatly.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in detail.
The invention provides a kind of Flos Plumeriae Acutifoliae effervescent tea tablet, comprise following component according to mass parts: 1 ~ 4 part, Flos Plumeriae Acutifoliae tea extract dry powder, Min return extract 5 parts-8 parts, mannitol, polyethylene glycol 6000 12 parts-16 parts, sodium bicarbonate 25 parts-35 parts, citric acid 1 part-2 parts, sweeting agent 2 parts-4 parts, Herba Menthae powdered flavor 2 parts-4 parts.
The present invention also provides a kind of preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet, comprises the following steps:
Step 1, prepare Flos Plumeriae Acutifoliae tea extract dry powder,
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 25-30kGy
60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 8-10 and doubly weighing, room temperature is heated to 75-90 DEG C, adds egg scented tea, stirring and extract 8-12 minute, 200-300 mesh filter screen and filter;
Step 1.3, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa--20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min-30000r/min;
Step 2, preparation Min return extract,
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract;
Step 3, weighing: weigh following material according to mass parts:
Step 4, by load weighted Flos Plumeriae Acutifoliae tea decocting liquid, mannitol, polyethylene glycol 6000 (PEG6000), sodium bicarbonate, citric acid, sweeting agent, Herba Menthae powdered flavor respectively porphyrize, cross 50 mesh sieves and make its mix homogeneously;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare Flos Plumeriae Acutifoliae effervescent tea tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C-78 DEG C, and pressure is 0.5MP-0.6MP.
Embodiment 1
A preparation method for Flos Plumeriae Acutifoliae effervescent tea tablet, comprises the following steps:
Step 1, prepare Flos Plumeriae Acutifoliae tea extract dry powder,
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 28kGy
60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 9 times of weights, room temperature is heated to 85 DEG C, adds egg scented tea, stirring extraction 10 minutes, 250 mesh filter screens filter;
Step 1.3, concentrate and carry out spraying dry: filtrate being heated to 70 DEG C, be decompressed to-18KPa-when being concentrated into 1/4 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 29000r/min;
Step 2, preparation Min return extract,
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 60 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 50% according to mass volume ratio (g/mL) for 1:25 takes Min;
Step 2.2, lixiviate: return sample 20min with the alcohol solution dipping Min that mass fraction is 50% are 200W at ultrasonic power, supersound extraction 70min under 55 DEG C of conditions, static 5min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 10min under rotating speed is 3000r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 50% to be the mass fraction weighed in step 2.1 be 50% alcoholic solution total amount; Merge supernatant, obtain Min and return extract;
Step 3, weighing: weigh following material according to mass parts:
Step 4, by load weighted Flos Plumeriae Acutifoliae tea decocting liquid, mannitol, polyethylene glycol 6000 (PEG6000), sodium bicarbonate, citric acid, sweeting agent, Herba Menthae powdered flavor respectively porphyrize, cross 50 mesh sieves and make its mix homogeneously;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare Flos Plumeriae Acutifoliae effervescent tea tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 75 DEG C, and pressure is 0.55MP.
Embodiment 2
A preparation method for Flos Plumeriae Acutifoliae effervescent tea tablet, comprises the following steps:
Step 1, prepare Flos Plumeriae Acutifoliae tea extract dry powder,
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 25kGy
60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 10 times of weights, room temperature is heated to 75 DEG C, adds egg scented tea, stirring extraction 8 minutes, 200 mesh filter screens filter;
Step 1.3, concentrate and carry out spraying dry: filtrate being heated to 60 DEG C, be decompressed to-15KPa when being concentrated into 1/4 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min;
Step 2, preparation Min return extract,
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20% according to mass volume ratio (g/mL) for 1:35 takes Min;
Step 2.2, lixiviate: return sample 15min with the alcohol solution dipping Min that mass fraction is 20% are 200W at ultrasonic power, supersound extraction 20min under 35 DEG C of conditions, static 3min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min under rotating speed is 2500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20% to be the mass fraction weighed in step 2.1 be 20% alcoholic solution total amount; Merge supernatant, obtain Min and return extract;
Step 3, weighing: weigh following material according to mass parts:
Step 4, by load weighted Flos Plumeriae Acutifoliae tea decocting liquid, mannitol, polyethylene glycol 6000 (PEG6000), sodium bicarbonate, citric acid, sweeting agent, Herba Menthae powdered flavor respectively porphyrize, cross 50 mesh sieves and make its mix homogeneously;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare Flos Plumeriae Acutifoliae effervescent tea tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C, and pressure is 0.5MP.
Embodiment 3
A preparation method for Flos Plumeriae Acutifoliae effervescent tea tablet, comprises the following steps:
Step 1, prepare Flos Plumeriae Acutifoliae tea extract dry powder,
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 30kGy
60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 8 times of weights, room temperature is heated to 90 DEG C, adds egg scented tea, stirring extraction 12 minutes, 300 mesh filter screens filter;
Step 1.3, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-20KPa when being concentrated into 1/3 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 30000r/min;
Step 2, preparation Min return extract,
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15 takes Min;
Step 2.2, lixiviate: return sample 25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 120min under 75 DEG C of conditions, static 7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 12min under rotating speed is 3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 70% to be the mass fraction weighed in step 2.1 be 70% alcoholic solution total amount; Merge supernatant, obtain Min and return extract;
Step 3, weighing: weigh following material according to mass parts:
Step 4, by load weighted Flos Plumeriae Acutifoliae tea decocting liquid, mannitol, polyethylene glycol 6000 (PEG6000), sodium bicarbonate, citric acid, sweeting agent, Herba Menthae powdered flavor respectively porphyrize, cross 50 mesh sieves and make its mix homogeneously;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare Flos Plumeriae Acutifoliae effervescent tea tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C-78 DEG C, and pressure is 0.6MP.
Comparative example
The effervescent tablet that common process prepares.
Below in conjunction with disintegration, subjective appreciation, hardness, outward appearance evaluate beneficial effect of the present invention:
1, disintegration time detects
In 250mL beaker, add the water of 200mL and water temperature is controlled then add 1 effervescent tablet 15 ~ 25.When gas around tablet or fragment stops overflowing, tablet should be dissolved or dispersed in water, left without the granule assembled.No longer include gas to solution to overflow and the time difference T (s) dissolved is the disintegration time of effervescent tablet, experimental result part table 1 from adding effervescent tablet.
2, subjective appreciation
Scoring: thrown by effervescent tablet in people 300mL water, adopt " double-blind method " to carry out sour-sweet degree organoleptic examination scoring, scoring number is 20 people, averages, full marks 100 points.This accounts for 40% of total score value.Disintegration time is marked, and detects disintegration time by 1, and the shortest for disintegration time in test is decided to be full marks 100 points, and disintegration time often increases 5s and subtracts 1 point.This scoring accounts for total score value 60%, and outward appearance scoring accounts for 20%, mouthfeel 20%, experimental result part table 1.
3, hardness (Monsanto durometer method)
Be placed on by tablet between two pressing plates, diametrically pressurization slowly, the pressure just during fragmentation is the hardness of this effervescent tablet, and unit is N, experimental result part table 1.
4, the test of pesticide effectiveness
The routine patient of clinical observation 60, treatment group 30 example, matched group 30 example.Whole case history all meets case selection standard, man 36 example, female 24 example, age 35-48 year, the course of disease is the shortest 2 days, the longest 2 weeks, takes Flos Plumeriae Acutifoliae effervescent tea tablet one week.
Diagnosis basis: disconnected standard is based on the standard of anemopyretic cold card relevant in " disease of tcm Standardization of diagnosis and curative effect ", and 1. heating, micro evil wind are trembled with fear, have a stuffy nose watery nasal discharge, sneeze, headache, general malaise.2. light red tongue or limit point red, platform book is yellow, floating and rapid pulse.3. unusual weather conditions or daily life cause accidentally, sudden onset.
Symptom and sign ranking criterion: according to correlation intergal standard in " traditional Chinese medical science Clinical Researches of New Drugs guideline ", the disappearance of headache, general pain, watery nasal discharge, pharyngalgia, pharyngeal congestion, cough, slight, moderate, severe long-pending 0,1,2,3 point respectively.
Inclusive criteria: meet the diagnostic criteria of traditional Chinese medical science anemopyretic cold card, body temperature is no more than 39 DEG C of persons, and the course of disease is person within 48h, and the age is between 18 ~ 65 years old.
Excluded cases standard: used medicine person as antibiotic, hormone or other cold medicines person or the person that do not bring down a fever; Merge other primary disease persons of pulmonary, as pulmonary tuberculosis, lung swelling and pain person; Merge serious cardiovascular, liver, kidney and disease of hematopoietic system person; Age is under-18s or over-65s person or be trimester of pregnancy, women breast-feeding their children, and body constitution allergy sufferers.
Matched group: comparative example effervescent tablet, 3 times/d, 7d were 1 course for the treatment of.
Criterion of therapeutical effect: cardinal symptom sign curative effect determinate standard more than temperature decline 0.5C is onset, dropping to 37.4C is that temperature recovery is normal.Other symptom and sign integrations reduce by 1 and are divided into onset, and 0 is divided into disappearance.Comprehensive therapeutic effect criterion is fully recovered: within treatment 3d, temperature recovery is normal, and sings and symptoms all disappears, or symptom, somatic feature score decline more than 90% person; Effective: within treatment 3d, body temperature is normal, and most of sings and symptoms disappears, or symptom, somatic feature score decline more than 75% person; Effective: treatment 3d within body temperature reduce than before, cardinal symptom and sign partial disappearance, or symptom, somatic feature score decline more than 50% person; Invalid: within treatment 3d, body temperature does not fall or raises, cardinal symptom and sign are without improvement or improve <50%.Therapeutic outcome: in table 2.
Contrast with embodiments of the invention 1-5 and comparative example, draw the following conclusions.
Table 1 comparing result
Disintegration (s) | Sensory evaluation scores (dividing) | Hardness (N) | |
Embodiment 1 | 102s | 100 | 65N |
Embodiment 2 | 124s | 89 | 62N |
Embodiment 3 | 115s | 94 | 69N |
Comparative example | 445s | 37 | 63N |
The observation of curative effect of this effervescent tablet of table 2 treatment anemopyretic cold patient
Group | Total number of cases | Recovery from illness | Effective | Effectively | Invalid | Total effective rate |
Embodiment 1 | 30 | 26 | 2 | 1 | 1 | 96.7% |
Embodiment 2 | 30 | 16 | 5 | 6 | 3 | 90% |
Embodiment 3 | 30 | 18 | 4 | 3 | 5 | 83.3% |
Comparative example | 30 | 6 | 4 | 5 | 15 | 50% |
As shown in Table 2, illustrate that the active ingredient ratio in effervescent tablet of the present invention is easier to extract, effervescent tablet treatment anemopyretic cold effect of the present invention is higher than existing Flos Plumeriae Acutifoliae effervescent tea tablet.
1., according to the inventive method, the application manually produces 150 batches of Flos Plumeriae Acutifoliae effervescent tea tablets altogether, conforming product rate 100%;
2. according to national standard, 24 months Flos Plumeriae Acutifoliae effervescent tea tablet effect duration, the applicant's reserved sample observing to 36 month, every quality index has not yet to see obvious change;
3. embodiment 1-5 and comparative example illustrate and the invention solves the slow difficult problem of Effervescent tablet disintegration, the screening by the proportioning to egg scented tea and the screening to gas-producing disintegrant and lubricant etc., make Flos Plumeriae Acutifoliae effervescent tea tablet of the present invention obtain best effervescent effect;
4. can be found out by above-mentioned result of the test, it is fast that Flos Plumeriae Acutifoliae effervescent tea tablet of the present invention has disintegrate compared with prior art products, and good stability, the advantages such as weight differential is little, can provide more stable, effective, safe product for patient.
5. the Flos Plumeriae Acutifoliae effervescent tea tablet prepared, smooth appearance, uniform color, sweet and sour taste, this stable process conditions of experiment results proved is feasible.
Claims (7)
1. a Flos Plumeriae Acutifoliae effervescent tea tablet, it is characterized in that, comprise following component according to mass parts: 1 ~ 4 part, Flos Plumeriae Acutifoliae tea extract dry powder, Min return extract 5 parts-8 parts, mannitol, polyethylene glycol 6000 12 parts-16 parts, sodium bicarbonate 25 parts-35 parts, citric acid 1 part-2 parts, sweeting agent 2 parts-4 parts, Herba Menthae powdered flavor 2 parts-4 parts.
2. Flos Plumeriae Acutifoliae effervescent tea tablet according to claim 1, is characterized in that, described Flos Plumeriae Acutifoliae tea extract dry powder prepares in the following manner:
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 25-30kGy
60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 8-10 and doubly weighing, room temperature is heated to 75-90 DEG C, adds egg scented tea, stirring and extract 8-12 minute, 200-300 mesh filter screen and filter;
Step 1.3, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa--20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min-30000r/min.
3. Flos Plumeriae Acutifoliae effervescent tea tablet according to claim 1, is characterized in that, described Min returns extract to prepare in the following manner:
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract.
4. a preparation method for Flos Plumeriae Acutifoliae effervescent tea tablet, is characterized in that, comprises the following steps:
Step 1, prepare Flos Plumeriae Acutifoliae tea extract dry powder,
Step 2, preparation Min return extract,
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract;
Step 3, weighing: weigh following component according to mass parts: 1 ~ 4 part, Flos Plumeriae Acutifoliae tea extract dry powder, Min return extract 5 parts-8 parts, mannitol, polyethylene glycol 6000 12 parts-16 parts, sodium bicarbonate 25 parts-35 parts, citric acid 1 part-2 parts, sweeting agent 2 parts-4 parts, Herba Menthae powdered flavor 2 parts-4 parts;
Step 4, by load weighted Flos Plumeriae Acutifoliae decocting liquid, mannitol, polyethylene glycol 6000 (PEG6000), sodium bicarbonate, citric acid, sweeting agent, Herba Menthae powdered flavor respectively porphyrize, cross 50 mesh sieves and make its mix homogeneously;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare Flos Plumeriae Acutifoliae effervescent tea tablet.
5. the preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet according to claim 4, is characterized in that, described step 1) in Flos Plumeriae Acutifoliae tea extract dry powder prepare by the following method:
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 25-30kGy
60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 8-10 and doubly weighing, room temperature is heated to 75-90 DEG C, adds egg scented tea, stirring and extract 8-12 minute, 200-300 mesh filter screen and filter;
Step 1.3, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa--20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min-30000r/min.
6. the preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet according to claim 4, is characterized in that, described step 2) in Min return extract to prepare by the following method:
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract.
7. the preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet according to claim 4, is characterized in that, described grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C-78 DEG C, and pressure is 0.5MP-0.6MP.
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Application publication date: 20160511 |