CN105560317A - Effervescent tablets containing frangipani tea, and preparation method of effervescent tablets - Google Patents

Effervescent tablets containing frangipani tea, and preparation method of effervescent tablets Download PDF

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CN105560317A
CN105560317A CN201510903694.4A CN201510903694A CN105560317A CN 105560317 A CN105560317 A CN 105560317A CN 201510903694 A CN201510903694 A CN 201510903694A CN 105560317 A CN105560317 A CN 105560317A
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parts
tea
extract
flos plumeriae
plumeriae acutifoliae
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保泽庆
闫莉
赵燕芬
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Zhaoqing Medical Higher College
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses effervescent tablets containing frangipani tea. The effervescent tablets are prepared from the following components in parts by weight: 1-4 parts of dry frangipani tea extract powder, 5-8 parts of extract of radix angelicae sinensis produced in Min county, 12-16 parts of mannitol, 12-16 parts of polyethylene glycol 6000, 25-35 parts of sodium bicarbonate, 1-2 parts of citric acid, 2-4 parts of sweetening agent and 2-4 parts of mint powder essence. The invention also discloses a preparation method of the effervescent tablets containing the frangipani tea. After the preparation method is adopted, the medicinal composition in dried tangerine peel can be fully extracted; the effect of preventing fatty liver of the effervescent tablets can be improved.

Description

A kind of Flos Plumeriae Acutifoliae effervescent tea tablet and preparation method thereof
Technical field
The invention belongs to Chinese herbal medicine preparation technology field, be specifically related to a kind of Flos Plumeriae Acutifoliae effervescent tea tablet, the invention still further relates to a kind of preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet.
Background technology
Often the Flos Plumeriae Acutifoliae of white is dried in In Guangdong Province and make antipyretic beverage, be popular; Cool in nature, sweet in the mouth, light; Return large intestine, stomach warp, there is effect of lung moistening removing toxic substances, clearing heat and expelling damp, laxation.Saying it as " south of the Five Ridges gather medicinal herbs record " can " controls damp-heat diarrhea, pain in the abdomen tongue weight, again can lung moistening removing toxic substances ".Though Fructus Momordicae charantiae is bitter, bitterness is cool in nature, feels more cool and comfortable after eating during summer-heat day, has the effect of the appetizing that clears away heart-fire.
At present, the use for Flos Plumeriae Acutifoliae generally still rests on traditional herbal tea and decocts, and use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of Flos Plumeriae Acutifoliae is obviously reduced simultaneously, greatly hinders the promotion and application of Flos Plumeriae Acutifoliae.Therefore, at present in the urgent need to providing a kind of Flos Plumeriae Acutifoliae dosage form easy to use, to adapt to the demand of consumers in general, significantly promoted the quality of life of people.
Effervescent tablet is a kind of tablet containing gas-producing disintegrant.The mixture of so-called gas-producing disintegrant normally organic acid and sodium carbonate, sodium bicarbonate (sodium bicarbonate); The dry moisture-free of effervescent tablet itself, two kinds of materials in gas-producing disintegrant are unionized can not react; But after water put into by effervescent tablet, two kinds of material generation acid-base reactions, produce great amount of carbon dioxide, make the rapid disintegrate of tablet and thawing, and the bubble that disintegrate sometimes produces also can make tablet roll up and down in water, accelerates its disintegrate and thawing.The carbon dioxide produced during disintegration of tablet is partially dissolved in drinking-water, has the aesthetic feeling as soda pop when drinking-water is drunk in entrance.At present, effervescent tablet is at home and abroad widely used, and common are oral effervescent tablet, vagina effervescence; Have also appeared Traditional Chinese medicine foot-bath effervescent tablet etc. in recent years.
Egg scented tea is a kind of folks of china tradition beverage, one of herbal tea that Cantonese often drinks, use for egg scented tea generally still rests on traditional herbal tea and decocts, use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of egg scented tea is obviously reduced simultaneously, greatly hinder the promotion and application of egg scented tea.Have in current Flos Plumeriae Acutifoliae effervescent tea tablet that disintegrate is slow, active component in egg scented tea is difficult to the problem that is dissolved out.
Summary of the invention
The object of this invention is to provide a kind of Flos Plumeriae Acutifoliae effervescent tea tablet, solve that the disintegrate that exists in prior art is slow, composition and effectiveness in egg scented tea is difficult to the problem that is dissolved out.
Another object of the present invention is to provide the preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet.
First technical scheme of the present invention is, a kind of Flos Plumeriae Acutifoliae effervescent tea tablet, comprises following component according to mass parts: 1 ~ 4 part, Flos Plumeriae Acutifoliae tea extract dry powder, Min return extract 5 parts-8 parts, mannitol, polyethylene glycol 6000 12 parts-16 parts, sodium bicarbonate 25 parts-35 parts, citric acid 1 part-2 parts, sweeting agent 2 parts-4 parts, Herba Menthae powdered flavor 2 parts-4 parts.
Further, Flos Plumeriae Acutifoliae tea extract dry powder prepares in the following manner:
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 25-30kGy 60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 8-10 and doubly weighing, room temperature is heated to 75-90 DEG C, adds egg scented tea, stirring and extract 8-12 minute, 200-300 mesh filter screen and filter;
Step 1.3, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa--20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min-30000r/min.
Further, Min returns extract to prepare in the following manner:
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract.
Second technical scheme of the present invention is, a kind of preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet, comprises the following steps:
Step 1, prepare Flos Plumeriae Acutifoliae tea extract dry powder,
Step 2, preparation Min return extract,
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract;
Step 3, weighing: weigh following component according to mass parts: 1 ~ 4 part, Flos Plumeriae Acutifoliae tea extract dry powder, Min return extract 5 parts-8 parts, mannitol, polyethylene glycol 6000 12 parts-16 parts, sodium bicarbonate 25 parts-35 parts, citric acid 1 part-2 parts, sweeting agent 2 parts-4 parts, Herba Menthae powdered flavor 2 parts-4 parts;
Step 4, by load weighted Flos Plumeriae Acutifoliae tea decocting liquid, mannitol, polyethylene glycol 6000 (PEG6000), sodium bicarbonate, citric acid, sweeting agent, Herba Menthae powdered flavor respectively porphyrize, cross 50 mesh sieves and make its mix homogeneously;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare Flos Plumeriae Acutifoliae effervescent tea tablet.
Further, step 1) in Flos Plumeriae Acutifoliae tea extract dry powder prepare by the following method:
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 25-30kGy 60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 8-10 and doubly weighing, room temperature is heated to 75-90 DEG C, adds egg scented tea, stirring and extract 8-12 minute, 200-300 mesh filter screen and filter;
Step 1.3, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa--20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min-30000r/min.
Further, step 2) in Min return extract to prepare by the following method:
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract.
Further, grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C-78 DEG C, and pressure is 0.5MP-0.6MP.
The invention has the beneficial effects as follows: the disintegration of the Flos Plumeriae Acutifoliae effervescent tea tablet that this formula and preparation method obtain can reach 110s, solve the slow difficult problem of Effervescent tablet disintegration, screening by the proportioning to orange peel tea effervescent tablet and the screening to gas-producing disintegrant and lubricant etc., make orange peel tea effervescent tablet of the present invention obtain best effervescent effect.
Active ingredient in Pericarpium Citri Reticulatae can extract by the present invention fully; The preventive effect of fatty liver is improved.The present invention organically combines effervescent tablet preparation formulation and traditional herb tea, be convenient to produce and carry, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of herbal tea greatly.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in detail.
The invention provides a kind of Flos Plumeriae Acutifoliae effervescent tea tablet, comprise following component according to mass parts: 1 ~ 4 part, Flos Plumeriae Acutifoliae tea extract dry powder, Min return extract 5 parts-8 parts, mannitol, polyethylene glycol 6000 12 parts-16 parts, sodium bicarbonate 25 parts-35 parts, citric acid 1 part-2 parts, sweeting agent 2 parts-4 parts, Herba Menthae powdered flavor 2 parts-4 parts.
The present invention also provides a kind of preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet, comprises the following steps:
Step 1, prepare Flos Plumeriae Acutifoliae tea extract dry powder,
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 25-30kGy 60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 8-10 and doubly weighing, room temperature is heated to 75-90 DEG C, adds egg scented tea, stirring and extract 8-12 minute, 200-300 mesh filter screen and filter;
Step 1.3, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa--20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min-30000r/min;
Step 2, preparation Min return extract,
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract;
Step 3, weighing: weigh following material according to mass parts:
Step 4, by load weighted Flos Plumeriae Acutifoliae tea decocting liquid, mannitol, polyethylene glycol 6000 (PEG6000), sodium bicarbonate, citric acid, sweeting agent, Herba Menthae powdered flavor respectively porphyrize, cross 50 mesh sieves and make its mix homogeneously;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare Flos Plumeriae Acutifoliae effervescent tea tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C-78 DEG C, and pressure is 0.5MP-0.6MP.
Embodiment 1
A preparation method for Flos Plumeriae Acutifoliae effervescent tea tablet, comprises the following steps:
Step 1, prepare Flos Plumeriae Acutifoliae tea extract dry powder,
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 28kGy 60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 9 times of weights, room temperature is heated to 85 DEG C, adds egg scented tea, stirring extraction 10 minutes, 250 mesh filter screens filter;
Step 1.3, concentrate and carry out spraying dry: filtrate being heated to 70 DEG C, be decompressed to-18KPa-when being concentrated into 1/4 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 29000r/min;
Step 2, preparation Min return extract,
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 60 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 50% according to mass volume ratio (g/mL) for 1:25 takes Min;
Step 2.2, lixiviate: return sample 20min with the alcohol solution dipping Min that mass fraction is 50% are 200W at ultrasonic power, supersound extraction 70min under 55 DEG C of conditions, static 5min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 10min under rotating speed is 3000r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 50% to be the mass fraction weighed in step 2.1 be 50% alcoholic solution total amount; Merge supernatant, obtain Min and return extract;
Step 3, weighing: weigh following material according to mass parts:
Step 4, by load weighted Flos Plumeriae Acutifoliae tea decocting liquid, mannitol, polyethylene glycol 6000 (PEG6000), sodium bicarbonate, citric acid, sweeting agent, Herba Menthae powdered flavor respectively porphyrize, cross 50 mesh sieves and make its mix homogeneously;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare Flos Plumeriae Acutifoliae effervescent tea tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 75 DEG C, and pressure is 0.55MP.
Embodiment 2
A preparation method for Flos Plumeriae Acutifoliae effervescent tea tablet, comprises the following steps:
Step 1, prepare Flos Plumeriae Acutifoliae tea extract dry powder,
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 25kGy 60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 10 times of weights, room temperature is heated to 75 DEG C, adds egg scented tea, stirring extraction 8 minutes, 200 mesh filter screens filter;
Step 1.3, concentrate and carry out spraying dry: filtrate being heated to 60 DEG C, be decompressed to-15KPa when being concentrated into 1/4 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min;
Step 2, preparation Min return extract,
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20% according to mass volume ratio (g/mL) for 1:35 takes Min;
Step 2.2, lixiviate: return sample 15min with the alcohol solution dipping Min that mass fraction is 20% are 200W at ultrasonic power, supersound extraction 20min under 35 DEG C of conditions, static 3min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min under rotating speed is 2500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20% to be the mass fraction weighed in step 2.1 be 20% alcoholic solution total amount; Merge supernatant, obtain Min and return extract;
Step 3, weighing: weigh following material according to mass parts:
Step 4, by load weighted Flos Plumeriae Acutifoliae tea decocting liquid, mannitol, polyethylene glycol 6000 (PEG6000), sodium bicarbonate, citric acid, sweeting agent, Herba Menthae powdered flavor respectively porphyrize, cross 50 mesh sieves and make its mix homogeneously;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare Flos Plumeriae Acutifoliae effervescent tea tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C, and pressure is 0.5MP.
Embodiment 3
A preparation method for Flos Plumeriae Acutifoliae effervescent tea tablet, comprises the following steps:
Step 1, prepare Flos Plumeriae Acutifoliae tea extract dry powder,
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 30kGy 60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 8 times of weights, room temperature is heated to 90 DEG C, adds egg scented tea, stirring extraction 12 minutes, 300 mesh filter screens filter;
Step 1.3, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-20KPa when being concentrated into 1/3 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 30000r/min;
Step 2, preparation Min return extract,
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15 takes Min;
Step 2.2, lixiviate: return sample 25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 120min under 75 DEG C of conditions, static 7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 12min under rotating speed is 3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 70% to be the mass fraction weighed in step 2.1 be 70% alcoholic solution total amount; Merge supernatant, obtain Min and return extract;
Step 3, weighing: weigh following material according to mass parts:
Step 4, by load weighted Flos Plumeriae Acutifoliae tea decocting liquid, mannitol, polyethylene glycol 6000 (PEG6000), sodium bicarbonate, citric acid, sweeting agent, Herba Menthae powdered flavor respectively porphyrize, cross 50 mesh sieves and make its mix homogeneously;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare Flos Plumeriae Acutifoliae effervescent tea tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C-78 DEG C, and pressure is 0.6MP.
Comparative example
The effervescent tablet that common process prepares.
Below in conjunction with disintegration, subjective appreciation, hardness, outward appearance evaluate beneficial effect of the present invention:
1, disintegration time detects
In 250mL beaker, add the water of 200mL and water temperature is controlled then add 1 effervescent tablet 15 ~ 25.When gas around tablet or fragment stops overflowing, tablet should be dissolved or dispersed in water, left without the granule assembled.No longer include gas to solution to overflow and the time difference T (s) dissolved is the disintegration time of effervescent tablet, experimental result part table 1 from adding effervescent tablet.
2, subjective appreciation
Scoring: thrown by effervescent tablet in people 300mL water, adopt " double-blind method " to carry out sour-sweet degree organoleptic examination scoring, scoring number is 20 people, averages, full marks 100 points.This accounts for 40% of total score value.Disintegration time is marked, and detects disintegration time by 1, and the shortest for disintegration time in test is decided to be full marks 100 points, and disintegration time often increases 5s and subtracts 1 point.This scoring accounts for total score value 60%, and outward appearance scoring accounts for 20%, mouthfeel 20%, experimental result part table 1.
3, hardness (Monsanto durometer method)
Be placed on by tablet between two pressing plates, diametrically pressurization slowly, the pressure just during fragmentation is the hardness of this effervescent tablet, and unit is N, experimental result part table 1.
4, the test of pesticide effectiveness
The routine patient of clinical observation 60, treatment group 30 example, matched group 30 example.Whole case history all meets case selection standard, man 36 example, female 24 example, age 35-48 year, the course of disease is the shortest 2 days, the longest 2 weeks, takes Flos Plumeriae Acutifoliae effervescent tea tablet one week.
Diagnosis basis: disconnected standard is based on the standard of anemopyretic cold card relevant in " disease of tcm Standardization of diagnosis and curative effect ", and 1. heating, micro evil wind are trembled with fear, have a stuffy nose watery nasal discharge, sneeze, headache, general malaise.2. light red tongue or limit point red, platform book is yellow, floating and rapid pulse.3. unusual weather conditions or daily life cause accidentally, sudden onset.
Symptom and sign ranking criterion: according to correlation intergal standard in " traditional Chinese medical science Clinical Researches of New Drugs guideline ", the disappearance of headache, general pain, watery nasal discharge, pharyngalgia, pharyngeal congestion, cough, slight, moderate, severe long-pending 0,1,2,3 point respectively.
Inclusive criteria: meet the diagnostic criteria of traditional Chinese medical science anemopyretic cold card, body temperature is no more than 39 DEG C of persons, and the course of disease is person within 48h, and the age is between 18 ~ 65 years old.
Excluded cases standard: used medicine person as antibiotic, hormone or other cold medicines person or the person that do not bring down a fever; Merge other primary disease persons of pulmonary, as pulmonary tuberculosis, lung swelling and pain person; Merge serious cardiovascular, liver, kidney and disease of hematopoietic system person; Age is under-18s or over-65s person or be trimester of pregnancy, women breast-feeding their children, and body constitution allergy sufferers.
Matched group: comparative example effervescent tablet, 3 times/d, 7d were 1 course for the treatment of.
Criterion of therapeutical effect: cardinal symptom sign curative effect determinate standard more than temperature decline 0.5C is onset, dropping to 37.4C is that temperature recovery is normal.Other symptom and sign integrations reduce by 1 and are divided into onset, and 0 is divided into disappearance.Comprehensive therapeutic effect criterion is fully recovered: within treatment 3d, temperature recovery is normal, and sings and symptoms all disappears, or symptom, somatic feature score decline more than 90% person; Effective: within treatment 3d, body temperature is normal, and most of sings and symptoms disappears, or symptom, somatic feature score decline more than 75% person; Effective: treatment 3d within body temperature reduce than before, cardinal symptom and sign partial disappearance, or symptom, somatic feature score decline more than 50% person; Invalid: within treatment 3d, body temperature does not fall or raises, cardinal symptom and sign are without improvement or improve <50%.Therapeutic outcome: in table 2.
Contrast with embodiments of the invention 1-5 and comparative example, draw the following conclusions.
Table 1 comparing result
Disintegration (s) Sensory evaluation scores (dividing) Hardness (N)
Embodiment 1 102s 100 65N
Embodiment 2 124s 89 62N
Embodiment 3 115s 94 69N
Comparative example 445s 37 63N
The observation of curative effect of this effervescent tablet of table 2 treatment anemopyretic cold patient
Group Total number of cases Recovery from illness Effective Effectively Invalid Total effective rate
Embodiment 1 30 26 2 1 1 96.7％
Embodiment 2 30 16 5 6 3 90％
Embodiment 3 30 18 4 3 5 83.3％
Comparative example 30 6 4 5 15 50％
As shown in Table 2, illustrate that the active ingredient ratio in effervescent tablet of the present invention is easier to extract, effervescent tablet treatment anemopyretic cold effect of the present invention is higher than existing Flos Plumeriae Acutifoliae effervescent tea tablet.
1., according to the inventive method, the application manually produces 150 batches of Flos Plumeriae Acutifoliae effervescent tea tablets altogether, conforming product rate 100%;
2. according to national standard, 24 months Flos Plumeriae Acutifoliae effervescent tea tablet effect duration, the applicant's reserved sample observing to 36 month, every quality index has not yet to see obvious change;
3. embodiment 1-5 and comparative example illustrate and the invention solves the slow difficult problem of Effervescent tablet disintegration, the screening by the proportioning to egg scented tea and the screening to gas-producing disintegrant and lubricant etc., make Flos Plumeriae Acutifoliae effervescent tea tablet of the present invention obtain best effervescent effect;
4. can be found out by above-mentioned result of the test, it is fast that Flos Plumeriae Acutifoliae effervescent tea tablet of the present invention has disintegrate compared with prior art products, and good stability, the advantages such as weight differential is little, can provide more stable, effective, safe product for patient.
5. the Flos Plumeriae Acutifoliae effervescent tea tablet prepared, smooth appearance, uniform color, sweet and sour taste, this stable process conditions of experiment results proved is feasible.

Claims (7)

1. a Flos Plumeriae Acutifoliae effervescent tea tablet, it is characterized in that, comprise following component according to mass parts: 1 ~ 4 part, Flos Plumeriae Acutifoliae tea extract dry powder, Min return extract 5 parts-8 parts, mannitol, polyethylene glycol 6000 12 parts-16 parts, sodium bicarbonate 25 parts-35 parts, citric acid 1 part-2 parts, sweeting agent 2 parts-4 parts, Herba Menthae powdered flavor 2 parts-4 parts.
2. Flos Plumeriae Acutifoliae effervescent tea tablet according to claim 1, is characterized in that, described Flos Plumeriae Acutifoliae tea extract dry powder prepares in the following manner:
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 25-30kGy 60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 8-10 and doubly weighing, room temperature is heated to 75-90 DEG C, adds egg scented tea, stirring and extract 8-12 minute, 200-300 mesh filter screen and filter;
Step 1.3, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa--20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min-30000r/min.
3. Flos Plumeriae Acutifoliae effervescent tea tablet according to claim 1, is characterized in that, described Min returns extract to prepare in the following manner:
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract.
4. a preparation method for Flos Plumeriae Acutifoliae effervescent tea tablet, is characterized in that, comprises the following steps:
Step 1, prepare Flos Plumeriae Acutifoliae tea extract dry powder,
Step 2, preparation Min return extract,
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract;
Step 3, weighing: weigh following component according to mass parts: 1 ~ 4 part, Flos Plumeriae Acutifoliae tea extract dry powder, Min return extract 5 parts-8 parts, mannitol, polyethylene glycol 6000 12 parts-16 parts, sodium bicarbonate 25 parts-35 parts, citric acid 1 part-2 parts, sweeting agent 2 parts-4 parts, Herba Menthae powdered flavor 2 parts-4 parts;
Step 4, by load weighted Flos Plumeriae Acutifoliae decocting liquid, mannitol, polyethylene glycol 6000 (PEG6000), sodium bicarbonate, citric acid, sweeting agent, Herba Menthae powdered flavor respectively porphyrize, cross 50 mesh sieves and make its mix homogeneously;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare Flos Plumeriae Acutifoliae effervescent tea tablet.
5. the preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet according to claim 4, is characterized in that, described step 1) in Flos Plumeriae Acutifoliae tea extract dry powder prepare by the following method:
Step 1.1, Flos Plumeriae Acutifoliae tea powder is broken into tea powder, crosses 50 mesh sieves, through 25-30kGy 60co-gamma-ray irradiation;
Step 1.2, extract and filter: in extraction pot, add the water being equivalent to egg scented tea 8-10 and doubly weighing, room temperature is heated to 75-90 DEG C, adds egg scented tea, stirring and extract 8-12 minute, 200-300 mesh filter screen and filter;
Step 1.3, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa--20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be Flos Plumeriae Acutifoliae tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min-30000r/min.
6. the preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet according to claim 4, is characterized in that, described step 2) in Min return extract to prepare by the following method:
Step 2.1, Min return the pre-treatment of sample and weighing: under Min being attributed to the condition of 55 DEG C-65 DEG C, dry to constant weight, pulverize, and cross 60 mesh sieves, obtain Min and return sample; Sample and mass fraction is returned to be the alcoholic solution of 20%-70% according to mass volume ratio (g/mL) for 1:15-1:35 takes Min;
Step 2.2, lixiviate: return sample 15min-25min with the alcohol solution dipping Min that mass fraction is 20%-70% are 200W at ultrasonic power, supersound extraction 20min-120min under 35 DEG C of-75 DEG C of conditions, static 3min-7min;
Step 2.3, centrifugal treating: be separated residue with low speed centrifuge centrifugal 8min-12min under rotating speed is 2500r/min-3500r/min, stay supernatant; Condition in residue step 2.2 carries out centrifugal treating after carrying out lixiviate process again, repeat 2.1-2.3 time, the alcoholic solution total amount of the mass fraction wherein used in step 2.2 and step 2.3 is the total amount of the alcoholic solution of 20%-70% to be the mass fraction weighed in step 2.1 be 20%-70%; Merge supernatant, obtain Min and return extract.
7. the preparation method of Flos Plumeriae Acutifoliae effervescent tea tablet according to claim 4, is characterized in that, described grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C-78 DEG C, and pressure is 0.5MP-0.6MP.
CN201510903694.4A 2015-12-08 2015-12-08 Effervescent tablets containing frangipani tea, and preparation method of effervescent tablets Pending CN105560317A (en)

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Application publication date: 20160511